Detailed information for compound 1485434

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 376.879 | Formula: C23H21ClN2O
  • H donors: 1 H acceptors: 1 LogP: 4.75 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)C(=O)Nc1ccc(cc1)CN1CCc2c(C1)cccc2
  • InChi: 1S/C23H21ClN2O/c24-21-9-7-19(8-10-21)23(27)25-22-11-5-17(6-12-22)15-26-14-13-18-3-1-2-4-20(18)16-26/h1-12H,13-16H2,(H,25,27)
  • InChiKey: SONHVPLGNLUBDM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0128 0.0466
Schistosoma mansoni 6-phosphofructokinase 0.0113 0.145 0.145
Onchocerca volvulus 0.0012 0.0019 0.003
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0128 0.0128
Loa Loa (eye worm) fructose-bisphosphate aldolase 2 0.0094 0.1187 0.1865
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0012 0.0019 0.0000000011294
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0026 0.022 0.0862
Echinococcus multilocularis regulator of G protein signaling 0.002 0.0133 0.0133
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0632 0.0733
Onchocerca volvulus Subfamily M14A unassigned peptidase homolog 0.0057 0.0659 0.1035
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0395 0.0825
Loa Loa (eye worm) hypothetical protein 0.0024 0.0194 0.0304
Trypanosoma brucei DNA polymerase IV, putative 0.0076 0.0926 0.2075
Loa Loa (eye worm) hypothetical protein 0.0044 0.0479 0.0752
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0057 0.0663 0.0663
Giardia lamblia Hypothetical protein 0.0032 0.0308 0.0643
Loa Loa (eye worm) troponin 0.0066 0.0783 0.123
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.0822 0.1831
Onchocerca volvulus Cell death protein 3 homolog 0.0055 0.0632 0.0993
Trypanosoma cruzi DNA polymerase eta, putative 0.0081 0.1006 0.2265
Leishmania major glycosyl hydrolase-like protein 0.0014 0.0049 0.0012
Trypanosoma brucei metacaspase MCA2 0.0055 0.0632 0.1384
Echinococcus multilocularis oncosphere protein tso22e oncosphere protein tso22d oncosphere protein tso22c oncosphere protein tso22b oncosphere protein tso22 0.0137 0.18 0.18
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0313 0.4293 1
Giardia lamblia Kinase, PLK 0.0099 0.1261 0.2964
Brugia malayi hypothetical protein 0.002 0.0133 0.0209
Brugia malayi Protein kinase domain containing protein 0.0016 0.0082 0.0128
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0469 0.0539
Brugia malayi Uncoordinated protein 44 0.0014 0.0057 0.0089
Trypanosoma cruzi cyclin 6, putative 0.0077 0.0947 0.2125
Trichomonas vaginalis CMGC family protein kinase 0.0046 0.0504 0.058
Loa Loa (eye worm) jmjC domain-containing protein 0.0026 0.022 0.0346
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0307 0.0307
Echinococcus multilocularis chromobox protein 2 0.0012 0.0019 0.0019
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0283 0.1131
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0342 0.0537
Giardia lamblia Kinase, CMGC MAPK 0.0054 0.0619 0.14
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0054 0.0619 0.1353
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0553 0.0553
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0383 0.0436
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.0133 0.0209
Echinococcus granulosus dna polymerase kappa 0.0082 0.1023 0.1023
Schistosoma mansoni DNA helicase recq1 0.004 0.0418 0.0418
Trypanosoma cruzi DNA polymerase kappa, putative 0.0082 0.1023 0.2304
Echinococcus granulosus histone lysine methyltransferase setb 0.005 0.0557 0.0557
Schistosoma mansoni troponin I 0.0111 0.1422 0.1422
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0041 0.044 0.1802
Echinococcus granulosus thioredoxin glutathione reductase 0.004 0.0415 0.0415
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0054 0.0613 0.1338
Trypanosoma brucei chrX additional, unordered contigs 0.0017 0.0094 0.0116
Mycobacterium tuberculosis Probable dehydrogenase 0.0089 0.112 0.4659
Giardia lamblia Fructose-bisphosphate aldolase 0.0303 0.415 1
Loa Loa (eye worm) cyclin domain-containing protein 0.0032 0.0308 0.0484
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0307 0.0307
Trichomonas vaginalis DNA helicase recq, putative 0.0067 0.081 0.0946
Giardia lamblia Cyclin A 0.0032 0.0308 0.0643
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.038 0.038
Onchocerca volvulus 0.0057 0.0659 0.1035
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0014 0.0044 0.0044
Echinococcus granulosus caspase 3 0.0075 0.0921 0.0921
Brugia malayi Protein cec-1. 0.0012 0.0019 0.003
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0055 0.0632 0.0733
Plasmodium vivax flap endonuclease 1, putative 0.0027 0.0234 0.0922
Leishmania major DNA polymerase eta, putative 0.0043 0.0468 0.0998
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase 0.0094 0.1187 0.1187
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0283 0.0316
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0055 0.0632 0.2625
Onchocerca volvulus 0.0012 0.0019 0.003
Mycobacterium tuberculosis Probable oxidoreductase 0.0099 0.1262 0.5272
Brugia malayi Troponin T 0.0066 0.0783 0.123
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.1182 0.1182
Loa Loa (eye worm) DOMON domain-containing protein 0.007 0.0846 0.1328
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0176 0.2354 0.2794
Echinococcus multilocularis cyclins 0.0032 0.0308 0.0308
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.1023 0.2304
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0876 0.1025
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0027 0.0234 0.0448
Leishmania major mitochondrial DNA polymerase beta 0.0313 0.4293 1
Schistosoma mansoni flap endonuclease-1 0.0024 0.0198 0.0198
Giardia lamblia Phosphoglycerate kinase 0.0176 0.2354 0.5627
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.0822 0.1292
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.003
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0094 0.1187 0.2691
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.003
Brugia malayi Pre-SET motif family protein 0.0032 0.0307 0.0482
Brugia malayi SET domain containing protein 0.0014 0.0051 0.0081
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0395 0.0916
Onchocerca volvulus 0.0057 0.0659 0.1035
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0089 0.112 0.4659
Loa Loa (eye worm) MH2 domain-containing protein 0.0124 0.1607 0.2525
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0133 0.0209
Trypanosoma brucei mitotic cyclin 6 0.0077 0.0947 0.2125
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0342 0.0537
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0099 0.1262 0.4941
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0128 0.0363
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0093 0.1167 0.1833
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0102 0.0102
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0128 0.0128
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0383 0.0436
Toxoplasma gondii exonuclease III APE 0.0019 0.0128 0.0466
Echinococcus granulosus ATP dependent DNA helicase Q5 0.004 0.0418 0.0418
Schistosoma mansoni cyclin B 0.0077 0.0947 0.0947
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0133 0.0133
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0113 0.145 0.5811
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0553 0.0553
Loa Loa (eye worm) hypothetical protein 0.0086 0.1074 0.1687
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.004 0.0418 0.1709
Schistosoma mansoni alpha-glucosidase 0.0145 0.1914 0.1914
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0094 0.0116
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0176 0.2354 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0099 0.1261 0.1261
Giardia lamblia DNA damage repair protein 0.0017 0.0094 0.012
Chlamydia trachomatis pyruvate kinase 0.0035 0.0342 0.1289
Echinococcus multilocularis bloom syndrome protein 0.0067 0.081 0.081
Loa Loa (eye worm) hypothetical protein 0.0056 0.065 0.1021
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0054 0.0619 0.0972
Echinococcus granulosus caspase 8 0.0055 0.0632 0.0632
Trichomonas vaginalis pps1 dual specificty phosphatase, putative 0.06 0.8377 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0019 0.00000000031556
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0195 0.0654
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0089 0.112 0.4285
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.0035 0.0349 0.0349
Echinococcus multilocularis beta adrenergic receptor kinase 0.0022 0.0158 0.0158
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0019 0.0019
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.038 0.038
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0032 0.0308 0.0308
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0579 0.0579
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0283 0.1035
Schistosoma mansoni jumonji domain containing protein 0.0026 0.022 0.022
Loa Loa (eye worm) phosphofructokinase 0.0113 0.145 0.2278
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0054 0.0619 0.1353
Trypanosoma brucei metacaspase 0.0055 0.0632 0.1384
Echinococcus granulosus cyclin dependent kinase 0.0046 0.0504 0.0504
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0017 0.0094 0.0319
Plasmodium vivax DNA repair protein REV1, putative 0.0017 0.0094 0.0319
Trypanosoma brucei DNA damage repair protein, putative 0.0017 0.0094 0.0116
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0619 0.0718
Onchocerca volvulus Troponin I homolog 0.0111 0.1422 0.2234
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.0133 0.0133
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.005 0.0557 0.0557
Schistosoma mansoni jumonji/arid domain-containing protein 0.0099 0.1263 0.1263
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0619 0.0718
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0068 0.0822 0.0961
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0395 0.0449
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0128 0.0363
Brugia malayi cell division control protein 2 homolog 0.0046 0.0504 0.0792
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0176 0.2354 0.2794
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0099 0.1262 0.5272
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.014 0.0226
Brugia malayi Pre-SET motif family protein 0.0217 0.2928 0.46
Brugia malayi jmjC domain containing protein 0.0026 0.022 0.0346
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0046 0.0504 0.1082
Loa Loa (eye worm) hypothetical protein 0.0091 0.1147 0.1802
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.0195 0.0368
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.028 0.028
Loa Loa (eye worm) hypothetical protein 0.002 0.0133 0.0209
Loa Loa (eye worm) helicase 0.0012 0.0019 0.003
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.1023 0.2304
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0313 0.4293 1
Brugia malayi Troponin family protein 0.0111 0.1422 0.2234
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0128 0.0201
Loa Loa (eye worm) hypothetical protein 0.0066 0.0783 0.123
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0342 0.0537
Brugia malayi hypothetical protein 0.0066 0.0783 0.123
Plasmodium vivax hypothetical protein, conserved 0.003 0.028 0.1118
Echinococcus multilocularis phd:f box containing protein 0.0026 0.022 0.022
Loa Loa (eye worm) hypothetical protein 0.0029 0.0264 0.0415
Entamoeba histolytica protein kinase, putative 0.0094 0.1182 0.1391
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0094 0.0116
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0342 0.0537
Schistosoma mansoni hypothetical protein 0.002 0.0141 0.0141
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0458 0.6365 1
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0283 0.0316
Entamoeba histolytica hypothetical protein 0.0094 0.1182 0.1391
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0128 0.013
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0342 0.0386
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0413 0.0413
Giardia lamblia G2/mitotic-specific cyclin B 0.0077 0.0947 0.2199
Brugia malayi serine/threonine-protein kinase plk-2 0.0099 0.1261 0.1981
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0055 0.0632 0.2625
Entamoeba histolytica hypothetical protein 0.0012 0.0019 0.00000000031556
Onchocerca volvulus 0.0051 0.0579 0.0909
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1261 0.1486
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.003
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0283 0.0316
Echinococcus granulosus troponin i 0.0111 0.1422 0.1422
Trypanosoma cruzi cyclin, putative 0.0077 0.0947 0.2125
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0141 0.0141
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0383 0.0436
Trypanosoma cruzi metacaspase, putative 0.0055 0.0632 0.1384
Toxoplasma gondii NADPH-glutathione reductase 0.0014 0.0044 0.0107
Echinococcus granulosus muscleblind protein 0.0155 0.2048 0.2048
Echinococcus multilocularis lysosomal alpha glucosidase 0.0169 0.2247 0.2247
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0059 0.0059
Onchocerca volvulus 0.0458 0.6365 1
Schistosoma mansoni phosphatidylserine receptor 0.0026 0.022 0.022
Trichomonas vaginalis maltase-glucoamylase, putative 0.0014 0.0049 0.0036
Echinococcus granulosus jumonji domain containing 1A 0.0026 0.022 0.022
Trichomonas vaginalis DNA helicase recq, putative 0.0046 0.0499 0.0574
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0113 0.145 0.3309
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0504 0.0504
Schistosoma mansoni alpha glucosidase 0.0037 0.0383 0.0383
Trypanosoma brucei DNA polymerase eta, putative 0.0081 0.1006 0.2265
Schistosoma mansoni tyrosinase precursor 0.0093 0.1167 0.1167
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.028 0.1118
Brugia malayi CHD4 protein 0.0014 0.0047 0.0074
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.1023 0.2304
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.415 0.4942
Schistosoma mansoni jumonji domain containing protein 0.0139 0.1832 0.1832
Loa Loa (eye worm) troponin T 0.0066 0.0783 0.123
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.1023 0.2304
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0198 0.2672 0.2672
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.0822 0.0822
Entamoeba histolytica phosphoglycerate kinase, putative 0.0176 0.2354 0.2794
Schistosoma mansoni lozenge 0.0058 0.0668 0.0668
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0395 0.1517
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0395 0.0825
Brugia malayi regulator of G-protein signaling egl-10 0.0029 0.0264 0.0415
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1261 0.1486
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0094 0.1182 0.1857
Onchocerca volvulus 0.007 0.0846 0.1328
Giardia lamblia DINP protein human, muc B family 0.0062 0.0729 0.1668
Loa Loa (eye worm) inositol-1 0.0038 0.0395 0.062
Brugia malayi ImpB/MucB/SamB family protein 0.0081 0.1006 0.1581
Echinococcus multilocularis L aminoadipate semialdehyde 0.0086 0.1074 0.1074
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0019 0.00000000031556
Loa Loa (eye worm) hypothetical protein 0.0365 0.5044 0.7924
Echinococcus granulosus oncosphere protein Tso22e 0.0137 0.18 0.18
Onchocerca volvulus 0.0246 0.3353 0.5267
Schistosoma mansoni peptidylglycine monooxygenase 0.0365 0.5044 0.5044
Trypanosoma brucei pyruvate kinase 1, putative 0.0035 0.0342 0.0701
Loa Loa (eye worm) hypothetical protein 0.0014 0.0057 0.0089
Trypanosoma cruzi cdc2-related kinase 1 0.0046 0.0504 0.1082
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0148 0.1951 0.8132
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0876 0.1025
Loa Loa (eye worm) hypothetical protein 0.0068 0.0817 0.1284
Mycobacterium ulcerans DNA polymerase IV 0.0082 0.1023 0.2557
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0049 0.0036
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0395 0.1608
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0195 0.0755
Trypanosoma brucei cdc2-related kinase 1 0.0046 0.0504 0.1082
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0619 0.0718
Loa Loa (eye worm) fructose-bisphosphate aldolase 1 0.0094 0.1187 0.1865
Schistosoma mansoni z-protein (S1r protein) 0.0029 0.0264 0.0264
Echinococcus granulosus axis inhibition protein axin 0.002 0.0133 0.0133
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0046 0.0504 0.0792
Brugia malayi Protein kinase domain containing protein 0.0094 0.1182 0.1857
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0194 0.0304
Trichomonas vaginalis CMGC family protein kinase 0.0046 0.0504 0.058
Echinococcus granulosus regulator of G protein signaling 7 0.0029 0.0264 0.0264
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0014 0.0044 0.0044
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0183 0.0183
Brugia malayi Troponin T 0.0066 0.0783 0.123
Trypanosoma cruzi DNA polymerase kappa, putative 0.0082 0.1023 0.2304
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0019 0.00000000031556
Echinococcus granulosus pyruvate kinase 0.0035 0.0342 0.0342
Schistosoma mansoni hypothetical protein 0.0069 0.0827 0.0827
Echinococcus granulosus chromobox protein 1 0.0072 0.0876 0.0876
Schistosoma mansoni DNA polymerase IV / kappa 0.0017 0.0094 0.0094
Brugia malayi phosphofructokinase 0.0113 0.145 0.2278
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0283 0.1131
Onchocerca volvulus Troponin T, skeletal muscle homolog 0.0137 0.18 0.2827
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.415 0.4942
Mycobacterium ulcerans glutaminase 0.0283 0.3872 1
Echinococcus multilocularis cyclin B 0.0077 0.0947 0.0947
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0055 0.0632 0.0733
Entamoeba histolytica protein kinase domain containing protein 0.0094 0.1182 0.1391
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0055 0.0632 0.0733
Loa Loa (eye worm) RecQ helicase 0.0067 0.081 0.1272
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0383 0.0436
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0133 0.0137
Trypanosoma brucei phosphoglycerate kinase, putative 0.0065 0.077 0.1709
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0274 0.0274
Brugia malayi hypothetical protein 0.002 0.0133 0.0209
Trichomonas vaginalis cyclins, putative 0.0053 0.0601 0.0696
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0283 0.1035
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0063 0.0752 0.1849
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.065 0.065
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.145 0.1712
Schistosoma mansoni chromobox protein 0.0072 0.0876 0.0876
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0111 0.0175
Trypanosoma brucei pyruvate kinase 1 0.0035 0.0342 0.0701
Echinococcus multilocularis Ankyrin 0.0015 0.0059 0.0059
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0283 0.1131
Echinococcus multilocularis dna polymerase eta 0.0081 0.1006 0.1006
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0383 0.0436
Echinococcus granulosus mitogen activated protein kinase 3 0.0054 0.0619 0.0619
Onchocerca volvulus 0.0057 0.0659 0.1035
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0195 0.0654
Leishmania major metacaspase, putative 0.0055 0.0632 0.1384
Schistosoma mansoni axis inhibition protein axin 0.002 0.0133 0.0133
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0283 0.1131
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.1023 0.2304
Mycobacterium ulcerans pyruvate kinase 0.0035 0.0342 0.0778
Schistosoma mansoni chromobox protein 0.0012 0.0019 0.0019
Schistosoma mansoni eyes absent homolog 0.0091 0.1147 0.1147
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0158 0.0158
Schistosoma mansoni phd finger protein 0.0012 0.0026 0.0026
Schistosoma mansoni pyruvate kinase 0.0018 0.0103 0.0103
Echinococcus multilocularis peptidyl glycine alpha amidating monooxygenase 0.0365 0.5044 0.5044
Loa Loa (eye worm) hypothetical protein 0.002 0.0133 0.0209
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0487 0.1041
Brugia malayi PHD-finger family protein 0.0026 0.0218 0.0342
Toxoplasma gondii fructose-bisphosphate aldolase, putative 0.0094 0.1187 0.5003
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0042 0.0451 0.1849
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0141 0.0141
Schistosoma mansoni troponin t invertebrate 0.0137 0.18 0.18
Plasmodium vivax fructose 1,6-bisphosphate aldolase, putative 0.0094 0.1187 0.5003
Leishmania major hypothetical protein, conserved 0.0026 0.022 0.0415
Loa Loa (eye worm) hypothetical protein 0.0044 0.0479 0.0753
Echinococcus multilocularis Chromo domain 0.0012 0.0019 0.0019
Loa Loa (eye worm) heterochromatin protein 1 0.0072 0.0876 0.1376
Mycobacterium tuberculosis Probable reductase 0.0089 0.112 0.4659
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0049 0.0012
Brugia malayi Cyclin, N-terminal domain containing protein 0.0077 0.0947 0.1488
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0283 0.0316
Brugia malayi glutaminase DH11.1 0.0283 0.3872 0.6082
Giardia lamblia PHD finger protein 15 0.003 0.028 0.0575
Schistosoma mansoni ap endonuclease 0.0019 0.0128 0.0128
Trypanosoma cruzi CYC2-like cyclin, putative 0.0077 0.0947 0.2125
Plasmodium falciparum protein kinase 5 0.0046 0.0504 0.2076
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.0468 0.0998
Leishmania major pyruvate kinase 0.0035 0.0342 0.0701
Echinococcus multilocularis thioredoxin glutathione reductase 0.004 0.0415 0.0415
Mycobacterium ulcerans phosphoglycerate kinase 0.0176 0.2354 0.6036
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0026 0.022 0.0862
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0102 0.0102
Trypanosoma brucei DNA polymerase IV, putative 0.0082 0.1023 0.2304
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0133 0.0137
Entamoeba histolytica cyclin, putative 0.0032 0.0308 0.0346
Schistosoma mansoni phd/f-box containing protein 0.0026 0.022 0.022
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0012 0.0019 0.0019
Plasmodium falciparum pyruvate kinase 2 0.0018 0.0103 0.036
Trypanosoma cruzi metacaspase, putative 0.0055 0.0632 0.1384
Trichomonas vaginalis set domain proteins, putative 0.0246 0.3351 0.3987
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0133 0.0133
Schistosoma mansoni troponin I 0.0111 0.1422 0.1422
Entamoeba histolytica hypothetical protein 0.002 0.0133 0.0137
Echinococcus granulosus phd:f box containing protein 0.0026 0.022 0.022
Toxoplasma gondii thioredoxin reductase 0.0039 0.0408 0.1664
Echinococcus granulosus fructose 16 bisphosphate aldolase 0.0094 0.1187 0.1187
Echinococcus multilocularis jun protein 0.0085 0.1052 0.1052
Echinococcus granulosus Chromobox protein 3 0.0012 0.0019 0.0019
Echinococcus granulosus L aminoadipate semialdehyde 0.0086 0.1074 0.1074
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0141 0.0141
Brugia malayi Pyruvate kinase, M2 isozyme 0.0035 0.0342 0.0537
Loa Loa (eye worm) hypothetical protein 0.0045 0.049 0.077
Onchocerca volvulus Alhambra homolog 0.003 0.028 0.044
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0395 0.0449
Echinococcus granulosus chromobox protein 2 0.0012 0.0019 0.0019
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0383 0.0436
Trypanosoma brucei DNA polymerase IV, putative 0.0082 0.1023 0.2304
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0426 0.0669
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0744 0.1648
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0187 0.2506 0.3937
Brugia malayi 6-phosphofructokinase 0.0113 0.145 0.2278
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.415 0.4942
Plasmodium vivax pyruvate kinase, putative 0.0035 0.0342 0.1383
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0744 0.0744
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0014 0.0047 0.0047
Brugia malayi Bromodomain containing protein 0.0078 0.0954 0.1499
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0055 0.0632 0.0733
Echinococcus multilocularis dna polymerase kappa 0.0082 0.1023 0.1023
Schistosoma mansoni tyrosinase precursor 0.0093 0.1167 0.1167
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0027 0.0234 0.0448
Echinococcus multilocularis JmjC domain containing protein 4 0.0026 0.022 0.022
Trypanosoma brucei ISWI complex protein 0.0016 0.0076 0.0076
Brugia malayi Protein kinase domain containing protein 0.0046 0.0504 0.0792
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0014 0.0044 0.0107
Loa Loa (eye worm) hypothetical protein 0.0187 0.2506 0.3937
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0619 0.1353
Echinococcus granulosus cyclins 0.0032 0.0308 0.0308
Giardia lamblia Kinase, CMGC CDK 0.0046 0.0504 0.112
Schistosoma mansoni DNA polymerase eta 0.0081 0.1006 0.1006
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0049 0.0036
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0014 0.0044 0.0069
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0729 0.0729
Echinococcus granulosus axis inhibition protein axin 0.002 0.0133 0.0133
Trypanosoma brucei polo-like protein kinase 0.0099 0.1261 0.2864
Brugia malayi ImpB/MucB/SamB family protein 0.0055 0.0632 0.0993
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0141 0.0524
Onchocerca volvulus 0.0098 0.1237 0.1944
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.065 0.065
Loa Loa (eye worm) hypothetical protein 0.0092 0.1157 0.1818
Echinococcus multilocularis chromobox protein 1 0.0072 0.0876 0.0876
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0744 0.0744
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.415 0.4942
Schistosoma mansoni hypothetical protein 0.0021 0.0155 0.0155
Echinococcus granulosus caspase 2 0.0055 0.0632 0.0632
Schistosoma mansoni cyclin B3 0.0032 0.0308 0.0308
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0099 0.1261 0.2864
Trypanosoma cruzi polo-like protein kinase, putative 0.0099 0.1261 0.2864
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0342 0.0386
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0057 0.0089
Trypanosoma brucei fructose-bisphosphate aldolase, glycosomal, putative 0.0094 0.1187 0.2691
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0012 0.0019 0.0019
Trichomonas vaginalis CMGC family protein kinase 0.0046 0.0504 0.058
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0046 0.0504 0.0792
Brugia malayi Heterochromatin protein 1 0.0072 0.0876 0.1376
Brugia malayi MH2 domain containing protein 0.0124 0.1607 0.2525
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0744 0.0744
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.0133 0.0133
Schistosoma mansoni rab6-interacting 0.002 0.0141 0.0141
Schistosoma mansoni fructose 16-bisphosphate aldolase 0.0094 0.1187 0.1187
Loa Loa (eye worm) ShTK domain-containing protein 0.0093 0.1167 0.1833
Schistosoma mansoni lipoxygenase 0.002 0.0141 0.0141
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0057 0.0057
Brugia malayi Phosphoglycerate kinase 0.0065 0.077 0.121
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0426 0.0487
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0065 0.077 0.1709
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0065 0.077 0.1709
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0822 0.1831
Schistosoma mansoni pyruvate kinase 0.0035 0.0342 0.0342
Echinococcus granulosus beta-adrenergic receptor kinase 0.0022 0.0158 0.0158
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0049 0.0036
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0148 0.1951 0.8255
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0195 0.0395
Brugia malayi F/Y-rich N-terminus family protein 0.0014 0.0052 0.0082
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0026 0.022 0.0415
Brugia malayi 6-phosphofructokinase 0.0113 0.145 0.2278
Brugia malayi Bromodomain containing protein 0.0033 0.0315 0.0495
Loa Loa (eye worm) hypothetical protein 0.0073 0.0891 0.14
Echinococcus multilocularis peregrin 0.0042 0.0455 0.0455
Loa Loa (eye worm) troponin I 0.0111 0.1422 0.2234
Loa Loa (eye worm) MBCTL1 0.0056 0.065 0.1021
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0283 0.0582
Schistosoma mansoni zinc finger protein 0.002 0.0139 0.0139
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0383 0.0436
Brugia malayi hypothetical protein 0.002 0.0141 0.0222
Brugia malayi PHD-finger family protein 0.0012 0.002 0.0031
Schistosoma mansoni rab6-interacting 0.002 0.0141 0.0141
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0553 0.0553
Echinococcus granulosus 6 phosphofructokinase 0.0113 0.145 0.145
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0063 0.0752 0.1666
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0094 0.1182 0.2678
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.004 0.0418 0.1709
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0195 0.0755
Echinococcus granulosus fructose 16 bisphosphate aldolase 0.0094 0.1187 0.1187
Trypanosoma cruzi cdc2-related kinase 3 0.0046 0.0504 0.1082
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0485 0.1037
Echinococcus multilocularis pyruvate kinase 0.0018 0.0103 0.0103
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0148 0.1951 0.4982
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0619 0.0619
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.0035 0.0349 0.0349
Brugia malayi glutathione reductase 0.0039 0.0408 0.064
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0476 0.1016
Brugia malayi fructose-bisphosphate aldolase 2 0.0094 0.1187 0.1865
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0044 0.0474 0.0474
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0019 0.00000000031556
Echinococcus granulosus mitogen activated protein kinase 0.0054 0.0619 0.0619
Brugia malayi DOMON domain containing protein 0.007 0.0846 0.1328
Trypanosoma brucei hypothetical protein, conserved 0.0017 0.0094 0.0116
Loa Loa (eye worm) hypothetical protein 0.004 0.0416 0.0653
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0094 0.1182 0.2678
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0014 0.0044 0.0107
Echinococcus multilocularis flap endonuclease 1 0.0027 0.0234 0.0234
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.028 0.1118
Toxoplasma gondii hypothetical protein 0.0024 0.0198 0.0766
Trypanosoma cruzi DNA polymerase kappa, putative 0.0082 0.1023 0.2304
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0195 0.0356
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0258 0.0286
Loa Loa (eye worm) hypothetical protein 0.0049 0.0553 0.0869
Trypanosoma cruzi trypanothione reductase, putative 0.0039 0.0408 0.0856
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0085 0.1052 0.1052
Echinococcus granulosus dna polymerase eta 0.0081 0.1006 0.1006
Plasmodium falciparum glutathione reductase 0.0014 0.0044 0.0107
Echinococcus granulosus RUN 0.002 0.0141 0.0141
Echinococcus granulosus pyruvate kinase 0.0018 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.003 0.028 0.044
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0553 0.0553
Schistosoma mansoni axis inhibition protein axin 0.002 0.0133 0.0133
Schistosoma mansoni zinc finger protein 0.0016 0.0076 0.0076
Echinococcus multilocularis pyruvate kinase 0.0035 0.0342 0.0342
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0744 0.1829
Trichomonas vaginalis cyclin B3, putative 0.0032 0.0308 0.0346
Echinococcus multilocularis lysine specific demethylase 6a 0.0026 0.022 0.022
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0141 0.0524
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0055 0.0632 0.0733
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0632 0.0733
Echinococcus granulosus Ankyrin 0.0015 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0014 0.0049 0.0078
Onchocerca volvulus 0.0093 0.1167 0.1833
Trypanosoma brucei glucosidase, putative 0.0037 0.0383 0.0798
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0469 0.0539
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.0057 0.0089
Echinococcus multilocularis tumor protein p63 0.035 0.4821 0.4821
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.065 0.065
Onchocerca volvulus Serine\/threonine kinase homolog 0.0099 0.1261 0.1981
Echinococcus multilocularis cyclins 0.0032 0.0308 0.0308
Plasmodium vivax thioredoxin reductase, putative 0.0039 0.0408 0.1664
Schistosoma mansoni hypothetical protein 0.0016 0.0076 0.0076
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0383 0.0436
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0065 0.077 0.1709
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.0049 0.0078
Brugia malayi Thioredoxin reductase 0.0039 0.0408 0.064
Loa Loa (eye worm) jmjC domain-containing protein 0.0099 0.1263 0.1985
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0099 0.1262 0.5272
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0487 0.1041
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0133 0.0209
Plasmodium vivax JmjC domain containing protein 0.0026 0.022 0.0862
Echinococcus granulosus tumor protein p63 0.035 0.4821 0.4821
Trichomonas vaginalis DNA helicase recq1, putative 0.0067 0.081 0.0946
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0062 0.0729 0.3039
Schistosoma mansoni phosphoglycerate kinase 0.0176 0.2354 0.2354
Trypanosoma cruzi DNA damage repair protein, putative 0.0017 0.0094 0.0116
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0448 0.0448
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0395 0.0395
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0102 0.0102
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0383 0.0383
Loa Loa (eye worm) hypothetical protein 0.0026 0.022 0.0346
Echinococcus multilocularis lysine specific demethylase 5A 0.0097 0.1235 0.1235
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0094 0.1187 0.2691
Brugia malayi Muscleblind-like protein 0.0155 0.2048 0.3218
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0062 0.0729 0.2964
Trypanosoma brucei unspecified product 0.0038 0.039 0.0813
Brugia malayi DOMON domain containing protein 0.007 0.0846 0.1328
Loa Loa (eye worm) hypothetical protein 0.002 0.0133 0.0209
Entamoeba histolytica serine/threonine protein kinase, putative 0.0099 0.1261 0.1486
Trichomonas vaginalis DNA polymerase eta, putative 0.0082 0.1023 0.1201
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0448 0.0448
Brugia malayi mbt repeat family protein 0.0049 0.0553 0.0869
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0014 0.0044 0.0107
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0176 0.2354 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0383 0.0602
Echinococcus granulosus caspase 0.013 0.1702 0.1702
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0102 0.0102
Giardia lamblia Pyruvate kinase 0.0035 0.0342 0.0725
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0195 0.0755
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.145 0.1712
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.004 0.0418 0.0657
Onchocerca volvulus 0.0057 0.0659 0.1035
Toxoplasma gondii hypothetical protein 0.005 0.0568 0.235
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.145 0.1712
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0141 0.0141
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0383 0.0436
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0383 0.0798
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0383 0.0798
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0055 0.0632 0.0733
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0046 0.0499 0.1071
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0619 0.1353
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0128 0.0197
Trypanosoma cruzi cdc2-related kinase 3 0.0046 0.0504 0.1082
Loa Loa (eye worm) hypothetical protein 0.0155 0.2048 0.3218
Loa Loa (eye worm) jmjC domain-containing protein 0.0026 0.022 0.0346
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.016 0.2121 0.2121
Schistosoma mansoni hypothetical protein 0.0014 0.0057 0.0057
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0085 0.1052 0.1052
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.415 0.4942
Treponema pallidum ATP-dependent DNA helicase 0.002 0.014 0.0234
Brugia malayi Bromodomain containing protein 0.004 0.0415 0.0651
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.1023 0.2304
Schistosoma mansoni cyclins 0.0032 0.0308 0.0308
Brugia malayi MAP kinase sur-1 0.0054 0.0619 0.0972
Echinococcus granulosus cyclins 0.0032 0.0308 0.0308
Brugia malayi Death domain containing protein 0.0014 0.0057 0.0089
Schistosoma mansoni troponin I 0.0111 0.1422 0.1422
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0055 0.0632 0.0632
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0283 0.0316
Trypanosoma brucei unspecified product 0.0076 0.0926 0.2075
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.003
Echinococcus multilocularis muscleblind protein 0.0155 0.2048 0.2048
Brugia malayi fructose-bisphosphate aldolase 1 0.0094 0.1187 0.1865
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0019 0.00000000031556
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0383 0.0602
Entamoeba histolytica hypothetical protein 0.0024 0.0195 0.0211
Brugia malayi Cell death protein 3 precursor 0.0055 0.0632 0.0993
Echinococcus multilocularis caspase 3 0.0075 0.0921 0.0921
Loa Loa (eye worm) hypothetical protein 0.0012 0.002 0.0031
Schistosoma mansoni pyruvate kinase 0.0035 0.0342 0.0342
Leishmania major hypothetical protein, conserved 0.0016 0.0076 0.0076
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0028 0.0249 0.0249
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0019 0.0019
Echinococcus granulosus cyclin dependent kinase 5 0.0046 0.0504 0.0504
Brugia malayi hypothetical protein 0.0458 0.6365 1
Trypanosoma brucei Metacaspase-4 0.0055 0.0632 0.1384
Entamoeba histolytica dual specificity protein phosphatase, putative 0.06 0.8377 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.415 0.4942
Echinococcus multilocularis caspase 2 0.0055 0.0632 0.0632
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0342 0.0537
Brugia malayi jmjC domain containing protein 0.0026 0.022 0.0346
Leishmania major DNA polymerase kappa, putative 0.0062 0.0729 0.1612
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0395 0.0395
Trypanosoma brucei phosphoglycerate kinase 0.0176 0.2354 0.5437
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0822 0.1831
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.013 0.1702 0.1702
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0019 0.00000000031556
Schistosoma mansoni DNA helicase recq5 0.004 0.0418 0.0418
Trypanosoma brucei phosphoglycerate kinase 0.0176 0.2354 0.5437
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0148 0.1953 0.4494
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0176 0.2354 1
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0313 0.4293 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0082 0.1023 0.2304
Echinococcus granulosus zinc finger protein 0.002 0.0139 0.0139
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0046 0.0504 0.0792
Trypanosoma brucei unspecified product 0.0038 0.039 0.0813
Schistosoma mansoni jun-related protein 0.0069 0.0827 0.0827
Echinococcus multilocularis chromobox protein 1 0.0072 0.0876 0.0876
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.065 0.065
Loa Loa (eye worm) hypothetical protein 0.0051 0.0579 0.0909
Schistosoma mansoni regulator of G protein signaling 0.002 0.0133 0.0133
Loa Loa (eye worm) glutathione reductase 0.0039 0.0408 0.064
Schistosoma mansoni fructose 16-bisphosphate aldolase 0.0094 0.1187 0.1187
Trichomonas vaginalis cyclin D, putative 0.0032 0.0308 0.0346
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0158 0.0158
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.0365 0.5044 0.5044
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0012 0.0019 0.003
Schistosoma mansoni SET domain protein 0.0035 0.0349 0.0349
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0027 0.0234 0.0922
Echinococcus granulosus phosphoglycerate kinase 1 0.0176 0.2354 0.2354
Treponema pallidum fructose-bisphosphate aldolase 0.0303 0.415 1
Brugia malayi Valyl-tRNA synthetase 0.0012 0.0019 0.003
Schistosoma mansoni protein phosphatase 2C 0.0026 0.022 0.022
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0063 0.0752 0.0752
Brugia malayi jmjC domain containing protein 0.0026 0.022 0.0346
Entamoeba histolytica recQ family helicase, putative 0.0046 0.0499 0.0574
Schistosoma mansoni loxhd1 0.002 0.0141 0.0141
Brugia malayi N-terminal motif family protein 0.0187 0.2506 0.3937
Loa Loa (eye worm) hypothetical protein 0.0032 0.0302 0.0474
Giardia lamblia Sgs1 DNA helicase, putative 0.004 0.0418 0.0911
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0055 0.0632 0.0632
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.003
Echinococcus granulosus cyclin dependent kinase 1 0.0046 0.0504 0.0504
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0094 0.1187 0.2691
Schistosoma mansoni chromobox protein 0.0012 0.0019 0.0019
Echinococcus granulosus pyruvate kinase 0.0035 0.0342 0.0342
Brugia malayi Troponin I 0.0111 0.1422 0.2234
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0062 0.0729 0.1612
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0049 0.0036
Mycobacterium ulcerans hypothetical protein 0.0165 0.2191 0.5609
Echinococcus granulosus pyruvate kinase 0.0018 0.0103 0.0103
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.002 0.0133 0.0137
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0026 0.022 0.0415
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0365 0.5044 0.7924
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0019 0.00000000031556
Brugia malayi Glycosyl hydrolases family 31 protein 0.0169 0.2247 0.3531
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0077 0.0947 0.2125
Loa Loa (eye worm) transcription factor SMAD2 0.0124 0.1607 0.2525
Trichomonas vaginalis cyclin B, putative 0.0077 0.0947 0.111
Loa Loa (eye worm) glutaminase 0.0283 0.3872 0.6082
Echinococcus granulosus lysosomal alpha glucosidase 0.0169 0.2247 0.2247
Plasmodium falciparum cyclin 0.0032 0.0308 0.1238
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0049 0.0036
Schistosoma mansoni troponin I 0.0111 0.1422 0.1422
Echinococcus multilocularis lysosomal alpha glucosidase 0.0169 0.2247 0.2247
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1261 0.1486
Echinococcus multilocularis cyclins 0.0032 0.0308 0.0308
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.0133 0.0209
Schistosoma mansoni hypothetical protein 0.0107 0.1374 0.1374
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0046 0.0504 0.1082
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0099 0.1261 0.1981
Loa Loa (eye worm) hypothetical protein 0.0081 0.1006 0.1581
Leishmania major DNA polymerase kappa, putative 0.0017 0.0094 0.0116
Plasmodium falciparum glutathione reductase 0.0039 0.0408 0.1664
Trypanosoma brucei glycosyl hydrolase-like protein 0.0014 0.0049 0.0012
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0093 0.1167 0.1833
Schistosoma mansoni regulator of G protein signaling 0.002 0.0133 0.0133
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0128 0.0197
Trichomonas vaginalis cyclin B, putative 0.0077 0.0947 0.111
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.013 0.1702 0.1702
Echinococcus granulosus cyclins 0.0032 0.0308 0.0308
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0342 0.0701
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.028 0.028
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0019 0.00000000031556
Echinococcus multilocularis cyclin dependent kinase 1 0.0046 0.0504 0.0504
Echinococcus granulosus cyclin b3 0.0032 0.0308 0.0308
Echinococcus multilocularis cyclin dependent kinase 1 0.0046 0.0504 0.0504
Echinococcus multilocularis histone lysine N methyltransferase, H3 lysine 36 0.0012 0.0024 0.0024
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0093 0.1167 0.1833
Plasmodium vivax glutathione reductase, putative 0.0039 0.0408 0.1664
Brugia malayi Cyclin, N-terminal domain containing protein 0.0032 0.0308 0.0484
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0744 0.3106
Echinococcus multilocularis pyruvate kinase 0.0027 0.0239 0.0239
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0383 0.0436
Loa Loa (eye worm) RGS-3 protein 0.002 0.0133 0.0209
Echinococcus multilocularis phosphoglycerate kinase 1 0.0176 0.2354 0.2354
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.065 0.1021
Onchocerca volvulus 0.0049 0.0553 0.0869
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0019 0.00000000031556
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0128 0.0197
Trypanosoma brucei trypanothione reductase 0.0039 0.0408 0.0856
Trichomonas vaginalis glutathione reductase, putative 0.0014 0.0044 0.003
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0183 0.0183
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0365 0.5044 0.7924
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0128 0.013
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0283 0.0582
Brugia malayi jmjC domain containing protein 0.0099 0.1263 0.1985
Loa Loa (eye worm) hypothetical protein 0.005 0.0557 0.0876
Mycobacterium ulcerans hypothetical protein 0.0017 0.0094 0.0129
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0183 0.0183
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0026 0.022 0.0415
Echinococcus granulosus death domain containing protein 0.0014 0.0057 0.0057
Echinococcus multilocularis 6 phosphofructokinase 0.0113 0.145 0.145
Plasmodium falciparum phosphoglycerate kinase 0.0176 0.2354 1
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0176 0.2354 0.5437
Trichomonas vaginalis cyclin B, putative 0.0077 0.0947 0.111
Giardia lamblia Flap structure-specific endonuclease 0.0027 0.0234 0.0463
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.014 0.0519
Onchocerca volvulus Troponin T, skeletal muscle homolog 0.0066 0.0783 0.123
Echinococcus multilocularis regulator of G protein signaling 7 0.0029 0.0264 0.0264
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0744 0.1829
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0063 0.0752 0.3063
Echinococcus granulosus cyclins 0.0032 0.0308 0.0308
Schistosoma mansoni microtubule-associated protein tau 0.0714 1 1
Plasmodium falciparum DNA repair protein REV1, putative 0.0017 0.0094 0.0319
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0019 0.00000000031556
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0632 0.0733
Echinococcus multilocularis cyclins 0.0032 0.0308 0.0308
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0395 0.0825
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0744 0.0744
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.0822 0.0822
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.004 0.0418 0.1709
Schistosoma mansoni caspase-7 (C14 family) 0.013 0.1702 0.1702
Echinococcus multilocularis cyclin dependent kinase 5 0.0046 0.0504 0.0504
Trypanosoma brucei DNA damage repair protein, putative 0.0017 0.0094 0.0116
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0055 0.0632 0.0733
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase 0.0094 0.1187 0.1187
Onchocerca volvulus 0.002 0.0141 0.0222
Trypanosoma cruzi DNA damage repair protein, putative 0.0017 0.0094 0.0116
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.003
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0133 0.0133
Echinococcus granulosus cyclin B 0.0077 0.0947 0.0947
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0128 0.0204
Trypanosoma cruzi metacaspase 5, putative 0.0055 0.0632 0.1384
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0383 0.0798
Schistosoma mansoni 6-phosphofructokinase 0.0113 0.145 0.145
Plasmodium vivax protein kinase Crk2 0.0046 0.0504 0.2076
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0012 0.0019 0.0000000011294
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.1023 0.2304
Loa Loa (eye worm) tyrosinase 1 0.0093 0.1167 0.1833
Loa Loa (eye worm) hypothetical protein 0.0055 0.0632 0.0993
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0019 0.00000000031556
Schistosoma mansoni hypothetical protein 0.0012 0.0019 0.0019
Leishmania major fructose-1,6-bisphosphate aldolase 0.0094 0.1187 0.2691
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0133 0.0133
Echinococcus multilocularis cyclin b3 0.0032 0.0308 0.0308
Brugia malayi bZIP transcription factor family protein 0.0085 0.1052 0.1653
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0553 0.0553
Loa Loa (eye worm) hypothetical protein 0.004 0.0418 0.0657
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0303 0.415 0.4942
Schistosoma mansoni hypothetical protein 0.003 0.028 0.028
Echinococcus granulosus histone lysine N methyltransferase H3 lysine 36 0.0012 0.0024 0.0024
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0049 0.0012
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0054 0.0619 0.2568
Loa Loa (eye worm) hypothetical protein 0.0093 0.1167 0.1833
Loa Loa (eye worm) jmjC domain-containing protein 0.0026 0.022 0.0346
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0822 0.1831
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0022 0.0158 0.0248
Schistosoma mansoni caspase-3 (C14 family) 0.013 0.1702 0.1702
Brugia malayi hypothetical protein 0.002 0.0141 0.0222
Trichomonas vaginalis glutaminase, putative 0.0283 0.3872 0.461
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0012 0.0024 0.0024
Treponema pallidum phosphoglycerate kinase 0.0176 0.2354 0.5627
Echinococcus multilocularis cyclin B3 1 0.0032 0.0308 0.0308
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0176 0.2354 0.5437
Echinococcus granulosus fructose 16 bisphosphate aldolase 0.0094 0.1187 0.1187
Brugia malayi hypothetical protein 0.0091 0.1147 0.1802
Onchocerca volvulus 0.0032 0.0302 0.0474
Echinococcus multilocularis jumonji domain containing 1A 0.0026 0.022 0.022
Loa Loa (eye worm) hypothetical protein 0.002 0.0133 0.0209
Leishmania major trypanothione reductase 0.0039 0.0408 0.0856
Loa Loa (eye worm) hypothetical protein 0.0365 0.5044 0.7924
Loa Loa (eye worm) hypothetical protein 0.0176 0.2354 0.3699
Schistosoma mansoni jumonji/arid domain-containing protein 0.0099 0.1263 0.1263
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0128 0.013
Echinococcus granulosus dual specificity 0.0094 0.1182 0.1182
Schistosoma mansoni glutaminase 0.0283 0.3872 0.3872
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0099 0.1261 0.1261
Echinococcus multilocularis caspase 8 0.0055 0.0632 0.0632
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.145 0.1712
Schistosoma mansoni ap endonuclease 0.0019 0.0128 0.0128
Echinococcus granulosus nuclear factor of activated T cells 5 0.0074 0.0904 0.0904
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0014 0.0047 0.0047
Brugia malayi PXA domain containing protein 0.002 0.0133 0.0209
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0089 0.112 0.4659
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0039 0.0408 0.1574
Echinococcus multilocularis microtubule associated protein 2 0.0714 1 1
Brugia malayi chromobox protein homolog 3 0.004 0.0426 0.0669
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0632 0.0733
Loa Loa (eye worm) hypothetical protein 0.002 0.0141 0.0222
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0729 0.1612
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0133 0.0133
Trypanosoma cruzi ISWI complex protein 0.0016 0.0076 0.0076
Echinococcus multilocularis cyclins 0.0032 0.0308 0.0308
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0128 0.0201
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0093 0.1167 0.1833
Schistosoma mansoni peptidyl-glycine monooxygenase 0.0365 0.5044 0.5044
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.005 0.0557 0.0557
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0632 0.0733
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0283 0.0316
Schistosoma mansoni regulator of G protein signaling 0.002 0.0133 0.0133
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0089 0.112 0.4659
Echinococcus granulosus cyclin B3 1 0.0032 0.0308 0.0308
Trypanosoma cruzi metacaspase, putative 0.0055 0.0632 0.1384
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0619 0.0718
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0014 0.0049 0.0036
Entamoeba histolytica hypothetical protein 0.002 0.0133 0.0137
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0019 0.00000000031556
Trichomonas vaginalis flap endonuclease-1, putative 0.0027 0.0234 0.0258
Loa Loa (eye worm) hypothetical protein 0.002 0.0141 0.0222
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0113 0.145 0.6085
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0022 0.0158 0.0248
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0133 0.0137
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0469 0.0737
Trichomonas vaginalis cyclins, putative 0.0077 0.0947 0.111
Loa Loa (eye worm) hypothetical protein 0.0035 0.0342 0.0537
Brugia malayi PXA domain containing protein 0.002 0.0133 0.0209
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0559 0.0646
Schistosoma mansoni blooms syndrome DNA helicase 0.0047 0.0521 0.0521
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0035 0.0342 0.1289
Mycobacterium leprae Probable pyruvate kinase PykA 0.0035 0.0342 0.0679
Echinococcus granulosus pyruvate kinase 0.0018 0.0103 0.0103
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0046 0.0499 0.1071
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0559 0.0646
Schistosoma mansoni kinase 0.0051 0.0578 0.0578
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0082 0.1023 0.1201
Onchocerca volvulus 0.002 0.0141 0.0222
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0026 0.022 0.022
Echinococcus granulosus lysine specific demethylase 6a 0.0026 0.022 0.022
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0065 0.077 0.1709
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.1023 0.2304
Schistosoma mansoni SET domain protein 0.0014 0.0052 0.0052
Onchocerca volvulus 0.0066 0.0794 0.1248
Brugia malayi Inositol-1 0.0038 0.0395 0.062
Trichomonas vaginalis cyclins, putative 0.0032 0.0308 0.0346
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0019 0.00000000031556
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0195 0.0395
Brugia malayi jmjC domain containing protein 0.016 0.2121 0.3331
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.016 0.2121 0.2121
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0737 0.1157
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0022 0.0158 0.0248
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0046 0.0499 0.1071
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.004 0.0418 0.0657
Loa Loa (eye worm) CHromoDomain protein family member 0.0014 0.0047 0.0074
Echinococcus granulosus ATP dependent DNA helicase Q1 0.004 0.0418 0.0418
Entamoeba histolytica pyruvate kinase, putative 0.0024 0.0194 0.0209
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0176 0.2354 1
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0019 0.00000000031556
Schistosoma mansoni bromodomain containing protein 0.0065 0.0782 0.0782
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0476 0.1016
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0133 0.0209
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0476 0.1016
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0553 0.0553
Loa Loa (eye worm) hypothetical protein 0.0026 0.022 0.0346
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0258 0.0286
Loa Loa (eye worm) DOMON domain-containing protein 0.007 0.0846 0.1328
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0476 0.1016
Echinococcus granulosus expressed protein 0.0386 0.5341 0.5341
Giardia lamblia Kinase, CMGC CDK 0.0046 0.0504 0.112
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.0133 0.0133
Brugia malayi Troponin T 0.0066 0.0783 0.123
Echinococcus multilocularis dual specificity 0.0094 0.1182 0.1182
Loa Loa (eye worm) DOMON domain-containing protein 0.007 0.0846 0.1328
Trypanosoma cruzi cdc2-related kinase 1 0.0046 0.0504 0.1082
Echinococcus granulosus Chromo domain 0.0012 0.0019 0.0019
Entamoeba histolytica recQ family helicase, putative 0.002 0.0129 0.0132
Schistosoma mansoni regulator of G protein signaling 0.002 0.0133 0.0133
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0019 0.00000000031556
Echinococcus granulosus netrin receptor unc 5 0.0014 0.0057 0.0057
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.004 0.0418 0.0418
Loa Loa (eye worm) hypothetical protein 0.0111 0.1422 0.2234
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0395 0.0449
Loa Loa (eye worm) hypothetical protein 0.002 0.014 0.022
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0046 0.0504 0.0504
Echinococcus multilocularis mitogen activated protein kinase 3 0.0054 0.0619 0.0619
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0055 0.0632 0.0993
Loa Loa (eye worm) flap endonuclease-1 0.0027 0.0234 0.0368
Loa Loa (eye worm) 6-phosphofructokinase 0.0113 0.145 0.2278
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1261 0.1486
Loa Loa (eye worm) hypothetical protein 0.0111 0.1422 0.2234
Plasmodium vivax SET domain protein, putative 0.0032 0.0307 0.1231
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.004 0.0418 0.0418
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0065 0.077 0.1709
Brugia malayi DOMON domain containing protein 0.007 0.0846 0.1328
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0141 0.0141
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0342 0.0701
Trypanosoma brucei hypothetical protein, conserved 0.0017 0.0094 0.0116
Loa Loa (eye worm) hypothetical protein 0.0091 0.1147 0.1802
Echinococcus multilocularis troponin i 0.0111 0.1422 0.1422
Echinococcus multilocularis cyclins 0.0032 0.0308 0.0308
Mycobacterium tuberculosis Conserved hypothetical protein 0.0055 0.0632 0.2544
Trichomonas vaginalis mercuric reductase, putative 0.0014 0.0044 0.003
Toxoplasma gondii pyruvate kinase PyK1 0.0035 0.0342 0.1383
Echinococcus granulosus flap endonuclease 1 0.0027 0.0234 0.0234
Onchocerca volvulus 0.0093 0.1167 0.1833
Schistosoma mansoni hypothetical protein 0.0304 0.4172 0.4172
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0308 0.0346
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0176 0.2354 1
Trypanosoma brucei metacaspase MCA3 0.0055 0.0632 0.1384
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0158 0.0158
Loa Loa (eye worm) hypothetical protein 0.0015 0.0059 0.0092
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.145 0.1712
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0504 0.0504
Plasmodium falciparum metacaspase-like protein 0.0055 0.0632 0.2625
Entamoeba histolytica cyclin, putative 0.0077 0.0947 0.111
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.005 0.0557 0.0557
Mycobacterium ulcerans 6-phosphofructokinase 0.0113 0.145 0.3673
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.002 0.0129 0.0472
Plasmodium falciparum phd finger protein, putative 0.003 0.028 0.1118
Echinococcus granulosus jun protein 0.0085 0.1052 0.1052
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.018 0.2409 0.3785
Loa Loa (eye worm) thioredoxin reductase 0.0039 0.0408 0.064
Trypanosoma cruzi metacaspase, putative 0.0055 0.0632 0.1384
Entamoeba histolytica hypothetical protein 0.002 0.0133 0.0137
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0063 0.0752 0.1181
Plasmodium vivax phosphoglycerate kinase, putative 0.0176 0.2354 1
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.0822 0.1292
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0155 0.0243
Brugia malayi Doublecortin family protein 0.002 0.0141 0.0222
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0426 0.0487
Loa Loa (eye worm) hypothetical protein 0.002 0.0133 0.0209
Schistosoma mansoni hypothetical protein 0.0111 0.1422 0.1422
Echinococcus multilocularis regulator of G protein signaling 7 0.0029 0.0264 0.0264
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.065 0.065
Chlamydia trachomatis phosphoglycerate kinase 0.0176 0.2354 1
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0632 0.0733
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.0133 0.0133
Trichomonas vaginalis cyclin B, putative 0.0032 0.0308 0.0346
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0049 0.0036
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0113 0.145 0.3309
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.415 0.4942
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0014 0.0044 0.0044
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0283 0.1131
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0148 0.1953 0.4494
Entamoeba histolytica cell division protein kinase 2, putative 0.0046 0.0504 0.058
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0133 0.0133
Echinococcus multilocularis caspase 0.013 0.1702 0.1702
Echinococcus multilocularis fructose bisphosphate aldolase class I 0.0094 0.1187 0.1187
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0065 0.077 0.1709
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0133 0.0137
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0169 0.2247 0.3531
Leishmania major DNA polymerase eta, putative 0.0081 0.1006 0.2265
Loa Loa (eye worm) hypothetical protein 0.0092 0.1157 0.1818
Trichomonas vaginalis cyclins, putative 0.0077 0.0947 0.111
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0055 0.0632 0.2625
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0028 0.0249 0.0249
Brugia malayi jmjC domain containing protein 0.0026 0.022 0.0346
Schistosoma mansoni polycystin 1-related 0.002 0.0141 0.0141
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0133 0.0133
Brugia malayi Bloom's syndrome protein homolog 0.0067 0.081 0.1272
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0133 0.0133
Plasmodium falciparum JmjC domain-containing protein, putative 0.0026 0.022 0.0862
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0383 0.1559
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0086 0.1074 0.1074
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0012 0.0019 0.0019
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0094 0.1182 0.2678
Onchocerca volvulus 0.0093 0.1167 0.1833
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0057 0.0663 0.0663
Loa Loa (eye worm) hypothetical protein 0.0077 0.0947 0.1488
Entamoeba histolytica cyclin family protein 0.0032 0.0308 0.0346
Echinococcus multilocularis subfamily M14A unassigned peptidase 0.0057 0.0659 0.0659
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0487 0.1041
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0055 0.0632 0.0733
Loa Loa (eye worm) runx1 0.0058 0.0668 0.105
Plasmodium falciparum pyruvate kinase 0.0035 0.0342 0.1383
Plasmodium vivax pyruvate kinase 2, putative 0.0018 0.0103 0.036
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1261 0.1486
Echinococcus granulosus chromobox protein 1 0.0072 0.0876 0.0876
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0046 0.0504 0.2076
Onchocerca volvulus 0.0086 0.1074 0.1687
Onchocerca volvulus 0.0077 0.0947 0.1488
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0729 0.0729
Echinococcus multilocularis cyclin dependent kinase 0.0046 0.0504 0.0504
Trypanosoma cruzi cyclin, putative 0.0077 0.0947 0.2125
Plasmodium falciparum thioredoxin reductase 0.0039 0.0408 0.1664
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0049 0.0036
Echinococcus granulosus regulator of G protein signaling 7 0.0029 0.0264 0.0264
Brugia malayi PHD-finger family protein 0.003 0.028 0.044
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0057 0.0057
Trichomonas vaginalis cyclins, putative 0.0077 0.0947 0.111
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0342 0.0537
Loa Loa (eye worm) hypothetical protein 0.004 0.0426 0.0669
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0395 0.0449
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0195 0.0356
Echinococcus granulosus transcription factor Dp 1 0.004 0.0413 0.0413
Echinococcus multilocularis Protein lozenge 0.0058 0.0668 0.0668
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0014 0.0047 0.0047
Echinococcus multilocularis muscleblind protein 1 0.0155 0.2048 0.2048
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0094 0.1182 0.2678
Echinococcus multilocularis zinc finger protein 0.002 0.0139 0.0139
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0063 0.0752 0.0752
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0395 0.0825
Loa Loa (eye worm) PHD-finger family protein 0.003 0.028 0.044
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0383 0.0436
Schistosoma mansoni subfamily M14A unassigned peptidase (M14 family) 0.0057 0.0659 0.0659
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0128 0.0204
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0485 0.1037
Schistosoma mansoni serine/threonine protein kinase 0.0099 0.1261 0.1261
Loa Loa (eye worm) hypothetical protein 0.0082 0.1019 0.1601
Trypanosoma brucei cdc2-related kinase 3 0.0046 0.0504 0.1082
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.028 0.028
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0019 0.00000000031556
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.0033
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0303 0.415 0.4942
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0217 0.2928 0.46
Brugia malayi polk-prov protein 0.0045 0.0485 0.0761
Entamoeba histolytica protein kinase, putative 0.0094 0.1182 0.1391
Trypanosoma brucei RNA helicase, putative 0.0107 0.1374 0.3129
Leishmania major ATP-dependent phosphofructokinase 0.0113 0.145 0.3309
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0024 0.0191 0.0735
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0338 0.0659
Brugia malayi Associated with TFs and helicases family protein 0.0012 0.0019 0.003
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0063 0.0752 0.0752
Entamoeba histolytica cyclin family protein 0.0032 0.0308 0.0346
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0113 0.145 0.3424
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0086 0.1074 0.1687
Loa Loa (eye worm) hypothetical protein 0.0093 0.1167 0.1833
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0089 0.112 0.4659
Loa Loa (eye worm) hypothetical protein 0.0055 0.0632 0.0993
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.145 0.1712
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0055 0.0632 0.0733
Trichomonas vaginalis cyclin A, putative 0.0077 0.0947 0.111
Loa Loa (eye worm) ATP-dependent DNA helicase 0.004 0.0418 0.0657
Schistosoma mansoni alpha-glucosidase 0.0145 0.1914 0.1914
Trypanosoma cruzi ISWI complex protein 0.0016 0.0076 0.0076
Echinococcus multilocularis pyruvate kinase 0.0035 0.0342 0.0342
Loa Loa (eye worm) glutaminase 2 0.0283 0.3872 0.6082
Mycobacterium tuberculosis Conserved hypothetical protein 0.0165 0.2191 0.9293
Schistosoma mansoni chromobox protein 0.0072 0.0876 0.0876
Trypanosoma brucei metacaspase 5, putative 0.0055 0.0632 0.1384
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0014 0.0049 0.0078
Entamoeba histolytica Flap nuclease, putative 0.0027 0.0234 0.0258
Schistosoma mansoni inositol monophosphatase 0.0038 0.0395 0.0395
Echinococcus multilocularis RUN 0.002 0.0141 0.0141
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.145 0.1712
Onchocerca volvulus 0.0022 0.0163 0.0256
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0054 0.0619 0.1353
Echinococcus multilocularis mitogen activated protein kinase 0.0054 0.0619 0.0619
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1261 0.1486
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0195 0.0755
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0014 0.0044 0.0107
Loa Loa (eye worm) hypothetical protein 0.0045 0.0485 0.0761
Echinococcus granulosus cyclins 0.0032 0.0308 0.0308
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0024 0.0195 0.0654
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0055 0.0632 0.0632
Onchocerca volvulus Netrin receptor homolog 0.0014 0.0057 0.0089
Brugia malayi Common central domain of tyrosinase family protein 0.0093 0.1167 0.1833
Schistosoma mansoni phosphoglycerate kinase 0.0176 0.2354 0.2354
Loa Loa (eye worm) 6-phosphofructokinase 0.0113 0.145 0.2278
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0055 0.0632 0.0632
Loa Loa (eye worm) ShTK domain-containing protein 0.0093 0.1167 0.1833
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0074 0.0904 0.0904
Onchocerca volvulus 0.0093 0.1167 0.1833
Echinococcus granulosus fructose bisphosphate aldolase class I 0.0094 0.1187 0.1187
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0307 0.1231
Loa Loa (eye worm) hypothetical protein 0.0155 0.2048 0.3218
Entamoeba histolytica deoxycytidyl transferase, putative 0.0055 0.0632 0.0733
Echinococcus granulosus lysine specific demethylase 5A 0.0099 0.1263 0.1263
Echinococcus multilocularis pyruvate kinase 0.0018 0.0103 0.0103
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0029 0.0264 0.0415
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.0822 0.0822
Giardia lamblia Pyruvate kinase 0.0018 0.0103 0.0144
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1261 0.1486
Loa Loa (eye worm) hypothetical protein 0.0153 0.2027 0.3185
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0094 0.1187 0.2691
Plasmodium falciparum metacaspase 1 0.0055 0.0632 0.2625
Trypanosoma brucei protein kinase, putative 0.0054 0.0619 0.1353
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0553 0.0869
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0283 0.1131
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0133 0.0137
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0744 0.3031
Brugia malayi M-phase phosphoprotein, mpp8 0.0012 0.0019 0.003
Leishmania major DNA damage repair protein, putative 0.0017 0.0094 0.0116
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0133 0.0137
Schistosoma mansoni inositol monophosphatase 0.0038 0.0395 0.0395
Loa Loa (eye worm) hypothetical protein 0.0077 0.0947 0.1488
Plasmodium falciparum flap endonuclease 1 0.0027 0.0234 0.0922
Trypanosoma cruzi metacaspase 5, putative 0.0055 0.0632 0.1384
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0054 0.0619 0.1353
Brugia malayi hypothetical protein 0.0066 0.0794 0.1248
Echinococcus multilocularis netrin receptor unc 5 0.0014 0.0057 0.0057
Schistosoma mansoni regulator of G protein signaling 0.0029 0.0264 0.0264
Mycobacterium ulcerans DNA polymerase IV 0.0082 0.1023 0.2557
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0054 0.0619 0.1353
Entamoeba histolytica recQ family DNA helicase 0.002 0.014 0.0145
Loa Loa (eye worm) doublecortin family protein 0.002 0.0141 0.0222
Brugia malayi ShTK domain containing protein 0.0093 0.1167 0.1833
Loa Loa (eye worm) hypothetical protein 0.0047 0.052 0.0817
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0553 0.0553
Echinococcus granulosus JmjC domain containing protein 4 0.0026 0.022 0.022
Echinococcus multilocularis cyclins 0.0032 0.0308 0.0308
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0141 0.0141
Loa Loa (eye worm) hypothetical protein 0.0458 0.6365 1
Trichomonas vaginalis cyclin B, putative 0.0077 0.0947 0.111
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0553 0.0869
Loa Loa (eye worm) hypothetical protein 0.0042 0.045 0.0708
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0383 0.0383
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0128 0.0219
Trichomonas vaginalis cyclin D, putative 0.0032 0.0308 0.0346
Echinococcus granulosus bloom syndrome protein 0.0067 0.081 0.081
Plasmodium falciparum thioredoxin reductase 0.0014 0.0044 0.0107
Brugia malayi Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein 0.0185 0.2486 0.3906
Plasmodium falciparum fructose-bisphosphate aldolase 0.0094 0.1187 0.5003
Leishmania major pyruvate kinase 0.0035 0.0342 0.0701
Echinococcus granulosus peregrin 0.0042 0.0455 0.0455
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.014 0.0226
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0148 0.1953 0.4494
Brugia malayi Cyclin, N-terminal domain containing protein 0.0077 0.0947 0.1488
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0283 0.0316
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0055 0.0632 0.0993
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0057 0.0057
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0055 0.0638 0.1003
Entamoeba histolytica cell division protein kinase 2, putative 0.0046 0.0504 0.058
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0128 0.0197
Brugia malayi Pyruvate kinase, muscle isozyme 0.0035 0.0342 0.0537
Trypanosoma cruzi polo-like protein kinase, putative 0.0099 0.1261 0.2864
Leishmania major phosphoglycerate kinase B, cytosolic 0.0176 0.2354 0.5437
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0027 0.0234 0.0448
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0283 0.0316
Schistosoma mansoni terminal deoxycytidyl transferase 0.0055 0.0632 0.0632
Echinococcus multilocularis Chromobox protein 3 0.0012 0.0019 0.0019
Echinococcus granulosus subfamily M14A unassigned peptidase 0.0057 0.0659 0.0659
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.0133 0.0133
Brugia malayi mbt repeat family protein 0.0049 0.0553 0.0869
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0043 0.0468 0.1923
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0063 0.0752 0.1849
Toxoplasma gondii fructose-1,6-bisphosphate aldolase 0.0094 0.1187 0.5003
Onchocerca volvulus 0.007 0.0846 0.1328
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0032 0.0308 0.0308
Trichomonas vaginalis cyclins, putative 0.0077 0.0947 0.111
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase 0.0094 0.1187 0.1187
Leishmania major cyclin 0.0077 0.0947 0.2125
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0019 0.0000000011294
Echinococcus multilocularis pyruvate kinase 0.0018 0.0103 0.0103
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.1023 0.2304
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0198 0.2672 0.2672
Leishmania major phosphoglycerate kinase C, glycosomal 0.0176 0.2354 0.5437
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0128 0.0466
Brugia malayi Flap endonuclease-1 0.0027 0.0234 0.0368
Schistosoma mansoni dopamine-beta-monooxygenase 0.0692 0.9683 0.9683
Toxoplasma gondii fructose-1,6-bisphosphate aldolase 0.0094 0.1187 0.5003
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.415 0.4942
Onchocerca volvulus 0.0044 0.0474 0.0745
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0338 0.127
Echinococcus multilocularis expressed protein 0.0386 0.5341 0.5341
Schistosoma mansoni lipoxygenase 0.0057 0.0663 0.0663
Brugia malayi Phosphoglycerate kinase 0.0176 0.2354 0.3699
Schistosoma mansoni netrin receptor unc5 0.0014 0.0057 0.0057
Schistosoma mansoni caspase-7 (C14 family) 0.0055 0.0632 0.0632
Trypanosoma brucei phosphoglycerate kinase 0.0065 0.077 0.1709
Brugia malayi hypothetical protein 0.0012 0.0021 0.0033
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0014 0.0044 0.0107
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0283 0.1131
Plasmodium vivax hypothetical protein, conserved 0.0055 0.0632 0.2625
Plasmodium vivax metacaspase 1, putative 0.0055 0.0632 0.2625
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0744 0.1829
Toxoplasma gondii pyruvate kinase PyKII 0.0018 0.0103 0.036

Activities

Activity type Activity value Assay description Source Reference
Activity (ADMET) = 0 % Cytotoxicity against HEK293T cells at 20 uM by alamar blue assay ChEMBL. 22003428
IC50 (functional) > 20 uM PUBCHEM_BIOASSAY: SAR analysis of compounds that inhibit NOD2 revised. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1566, AID1575, AID1578, AID1579, AID1848, AID1849, AID1852, AID2469, AID2475, AID2799, AID2800] ChEMBL. No reference
IC50 (functional) > 20 uM PUBCHEM_BIOASSAY: SAR analysis of compounds that inhibit NOD1 revised. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1575, AID1578, AID2335, AID2466, AID2469, AID2505, AID2798, AID2800] ChEMBL. No reference
IC50 (functional) > 20 uM PUBCHEM_BIOASSAY: SAR analysis of inhibitors of TNFa specific NF-kB induction revised. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1566, AID1575, AID1578, AID1579, AID1852, AID2469, AID2483, AID2485, AID2800, AID2801] ChEMBL. No reference
IC50 (binding) > 20 uM Inhibition of NOD-1 mediated NFkappaB activation in HEK293T cells assessed as inhibition of gamma-tri-DAP-induced luciferase activity after 14 hrs by reporter gene assay ChEMBL. 22003428
IC50 (binding) > 20 uM Inhibition of NOD-2 mediated NFkappaB activation in HEK293T cells assessed as inhibition of MDP-induced luciferase activity after 14 hrs by reporter gene assay ChEMBL. 22003428

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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