Detailed information for compound 1559758

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 439.293 | Formula: C19H20Cl2N4O4
  • H donors: 3 H acceptors: 4 LogP: 5.35 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)OCCCNCc1cc(ccc1O)Nc1ccnc2c1ccc(c2)Cl.Cl
  • InChi: 1S/C19H19ClN4O4.ClH/c20-14-2-4-16-17(6-8-22-18(16)11-14)23-15-3-5-19(25)13(10-15)12-21-7-1-9-28-24(26)27;/h2-6,8,10-11,21,25H,1,7,9,12H2,(H,22,23);1H
  • InChiKey: IPASUHMKGBWLGE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0187 0.1864 0.3152
Trypanosoma brucei glucosidase, putative 0.0042 0.029 0.4474
Echinococcus granulosus single minded 2 0.0202 0.2032 0.3436
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0071 0.109
Loa Loa (eye worm) RGS-3 protein 0.0022 0.0069 0.0071
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0025 0.038
Brugia malayi Nuclear hormone receptor E75 0.0167 0.1646 0.1677
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.00809435 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0101 0.0929 0.157
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0353 0.3681 0.3681
Toxoplasma gondii exonuclease III APE 0.004 0.0266 0.2667
Loa Loa (eye worm) hypothetical protein 0.0043 0.0293 0.0298
Loa Loa (eye worm) hypothetical protein 0.0348 0.3627 0.3695
Loa Loa (eye worm) hypothetical protein 0.0032 0.0181 0.0185
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.00809435 1 1
Schistosoma mansoni cytochrome P450 0.0036 0.0219 0.037
Echinococcus multilocularis neutral alpha glucosidase AB 0.0042 0.029 0.029
Schistosoma mansoni thyroid hormone receptor 0.0498 0.526 0.8894
Loa Loa (eye worm) hypothetical protein 0.0116 0.1099 0.112
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0025 0.038
Mycobacterium leprae putative cytochrome p450 0.0036 0.0219 0.0805
Onchocerca volvulus 0.08 0.8557 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.00809435 1 1
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0036 0.0219 0.1561
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0036 0.0219 0.3373
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0071 0.0603 0.0704
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0187 0.1864 0.3152
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0069 0.008
Schistosoma mansoni hypothetical protein 0.0202 0.2031 0.3434
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0069 0.0117
Onchocerca volvulus 0.0097 0.0889 0.1038
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0353 0.3681 0.375
Schistosoma mansoni lamin 0.0092 0.0828 0.14
Onchocerca volvulus 0.0202 0.2032 0.2375
Schistosoma mansoni thyroid hormone receptor 0.00809435 1 1
Loa Loa (eye worm) steroid hormone receptor 0.0353 0.3681 0.375
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0036 0.0219 0.1561
Schistosoma mansoni retinoic acid receptor RXR 0.00809435 1 1
Brugia malayi hypothetical protein 0.0202 0.2031 0.2069
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0035 0.0211 0.3252
Onchocerca volvulus 0.00809435 1 1
Schistosoma mansoni hypothetical protein 0.0106 0.0984 0.1663
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.00809435 1 1
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0036 0.0219 0.0963
Onchocerca volvulus Protein ultraspiracle homolog 0.00809435 1 1
Brugia malayi SET domain containing protein 0.0017 0.0012 0.0013
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0129 0.1235 0.2089
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0071 0.109
Onchocerca volvulus 0.0116 0.1099 0.1285
Brugia malayi hypothetical protein 0.00427612 0.107081 0.107081
Echinococcus multilocularis ecdysone induced protein 78C 0.0353 0.3681 0.3681
Schistosoma mansoni smad 0.0035 0.0212 0.0358
Mycobacterium tuberculosis Probable dehydrogenase 0.0118 0.112 0.8837
Onchocerca volvulus 0.0174 0.1724 0.2015
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0071 0.0603 0.4877
Brugia malayi Nuclear hormone receptor family member nhr-3 0.00809435 1 1
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0036 0.0219 0.0963
Mycobacterium leprae Possible regulatory protein 0.0071 0.0603 0.4182
Schistosoma mansoni nuclear receptor nhr-48 0.0167 0.1646 0.2783
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0145 0.1408 0.2381
Echinococcus granulosus thyroid hormone receptor alpha 0.0167 0.1646 0.2783
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0353 0.3681 0.3681
Toxoplasma gondii thioredoxin reductase 0.0052 0.0395 0.4095
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0042 0.029 0.0295
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0036 0.0219 0.1561
Schistosoma mansoni nuclear hormone receptor 0.0167 0.1646 0.2783
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0071 0.0603 0.9317
Loa Loa (eye worm) glutathione reductase 0.0052 0.0395 0.0402
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0071 0.0072
Echinococcus granulosus L aminoadipate semialdehyde 0.0097 0.0889 0.1502
Trypanosoma cruzi trypanothione reductase, putative 0.0052 0.0395 0.6105
Echinococcus granulosus neuropeptide s receptor 0.0534 0.5649 0.9551
Echinococcus granulosus nuclear factor of activated T cells 5 0.0166 0.1634 0.2763
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0025 0.0253
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0132 0.1264 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0353 0.3681 0.375
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0071 0.0603 0.9317
Leishmania major trypanothione reductase 0.0052 0.0395 0.3195
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0101 0.0929 0.0929
Brugia malayi Nuclear hormone receptor-like 1 0.0187 0.1864 0.1899
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0025 0.038
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0036 0.0219 0.0963
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0025 0.038
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0106 0.0984 0.1002
Loa Loa (eye worm) hypothetical protein 0.0167 0.1646 0.1677
Schistosoma mansoni retinoid-x-receptor (RXR) 0.00809435 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.00809435 1 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0069 0.0071
Loa Loa (eye worm) hypothetical protein 0.0353 0.3681 0.375
Echinococcus multilocularis FTZ F1 alpha 0.0353 0.3681 0.3681
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0036 0.0219 0.1561
Loa Loa (eye worm) hypothetical protein 0.0167 0.1646 0.1677
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0269 0.2764 0.2815
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0353 0.3681 0.6224
Echinococcus granulosus TGF beta signal transducer SmadC 0.0035 0.0212 0.0358
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0071 0.0072
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0353 0.3681 0.375
Echinococcus granulosus FTZ F1 alpha 0.0353 0.3681 0.6224
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0071 0.109
Brugia malayi Muscleblind-like protein 0.0164 0.1617 0.1648
Brugia malayi A-kinase anchor protein 10, precursor 0.0022 0.0069 0.0071
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0036 0.0219 0.1561
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0036 0.0219 0.1561
Brugia malayi Glycosyl hydrolases family 31 protein 0.019 0.1905 0.1941
Brugia malayi nuclear receptor NHR-88 0.0353 0.3681 0.375
Echinococcus granulosus netrin receptor unc 5 0.0032 0.0181 0.0307
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0027 0.0127 0.0507
Loa Loa (eye worm) hypoxia-induced factor 1 0.0845 0.9044 0.9212
Schistosoma mansoni nuclear receptor 0.0167 0.1646 0.2783
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0167 0.1646 0.1646
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0353 0.3681 0.375
Echinococcus granulosus neutral alpha glucosidase AB 0.0042 0.029 0.049
Echinococcus granulosus bloom syndrome protein 0.0023 0.0084 0.0143
Loa Loa (eye worm) cytochrome P450 family protein 0.0075 0.0647 0.0659
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0266 0.1944
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0069 0.008
Brugia malayi Death domain containing protein 0.0032 0.0181 0.0185
Brugia malayi nuclear hormone receptor 0.0167 0.1646 0.1677
Schistosoma mansoni netrin receptor unc5 0.0032 0.0181 0.0307
Schistosoma mansoni alpha glucosidase 0.0042 0.029 0.049
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.00809435 1 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0071 0.0071
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0025 0.038
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0266 0.0266
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0167 0.1646 0.1646
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0187 0.1864 0.1899
Brugia malayi PXA domain containing protein 0.0022 0.0069 0.0071
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0069 0.0117
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0118 0.112 0.8837
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0266 0.1308
Schistosoma mansoni z-protein (S1r protein) 0.0022 0.0069 0.0117
Brugia malayi Nuclear hormone receptor-like 1 0.00427612 0.107081 0.107081
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0036 0.0219 0.0963
Schistosoma mansoni RAR-like nuclear receptor 0.00809435 1 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0266 0.4109
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0036 0.0219 0.0963
Loa Loa (eye worm) hypothetical protein 0.0044 0.0311 0.0317
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.00809435 1 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0266 0.2853
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0025 0.0025
Schistosoma mansoni coup transcription factor 0.00809435 1 1
Mycobacterium ulcerans putative regulatory protein 0.0202 0.2032 1
Leishmania major cytochrome p450-like protein 0.0075 0.0647 0.5234
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.029 0.0338
Entamoeba histolytica deoxycytidyl transferase, putative 0.0022 0.0071 0.0347
Brugia malayi Ets-domain containing protein 0.0071 0.0604 0.0615
Brugia malayi hypothetical protein 0.0022 0.0069 0.0071
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0266 0.0271
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0069 0.0117
Schistosoma mansoni RAR-like nuclear receptor 0.0353 0.3681 0.6224
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0025 0.0029
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0071 0.109
Schistosoma mansoni smad1 5 8 and 0.0035 0.0212 0.0358
Brugia malayi Nuclear hormone receptor family member nhr-19 0.00809435 1 1
Brugia malayi tailless protein 0.0167 0.1646 0.1677
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.029 0.0338
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0036 0.0219 0.0963
Loa Loa (eye worm) transcription factor SMAD2 0.0515 0.5445 0.5546
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0069 0.008
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0025 0.0253
Loa Loa (eye worm) hypothetical protein 0.0353 0.3681 0.375
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0071 0.109
Brugia malayi photoreceptor-specific nuclear receptor 0.00809435 1 1
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0069 0.0069
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0266 0.4109
Schistosoma mansoni transcription factor LCR-F1 0.0202 0.2031 0.3434
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0071 0.109
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.00809435 1 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0025 0.0199
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0025 0.038
Schistosoma mansoni thyroid hormone receptor 0.00809435 1 1
Brugia malayi MH1 domain containing protein 0.0035 0.0212 0.0216
Brugia malayi isocitrate dehydrogenase 0.0035 0.0211 0.0215
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0071 0.012
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0071 0.0072
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.029 0.1424
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0535 0.2538
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0084 0.0098
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0266 0.0271
Trichomonas vaginalis adenylate cyclase, putative 0.0071 0.0603 0.0704
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0535 0.2538
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0114 0.1072 0.1812
Brugia malayi Uncoordinated protein 44 0.0032 0.0181 0.0185
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0071 0.0071
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0025 0.0026
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0069 0.0117
Brugia malayi MH2 domain containing protein 0.0515 0.5445 0.5546
Loa Loa (eye worm) cytochrome P450 0.0036 0.0219 0.0223
Schistosoma mansoni smad1 5 8 and 0.0035 0.0212 0.0358
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0212 0.0216
Brugia malayi orphan nuclear receptor NR2E1 0.0167 0.1646 0.1677
Schistosoma mansoni single-minded 0.0273 0.2806 0.4745
Brugia malayi small heat shock protein 0.0634 0.6744 0.687
Brugia malayi Immunoglobulin I-set domain containing protein 0.0032 0.0181 0.0185
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0202 0.2031 0.2031
Loa Loa (eye worm) hypothetical protein 0.00809435 1 1
Onchocerca volvulus 0.0167 0.1646 0.1924
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0166 0.1634 0.1634
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0097 0.0888 0.1502
Onchocerca volvulus Bile acid receptor homolog 0.0353 0.3681 0.4302
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0036 0.0219 0.0963
Brugia malayi PXA domain containing protein 0.0022 0.0069 0.0071
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0036 0.0219 0.0963
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.00809435 1 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0035 0.0212 0.0358
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0031 0.0052
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0103 0.0956 0.1617
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0035 0.0211 0.5016
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0022 0.0069 0.0117
Loa Loa (eye worm) fli-1 protein 0.0216 0.2182 0.2222
Loa Loa (eye worm) hypothetical protein 0.00427612 0.107081 0.107081
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0036 0.0219 0.0963
Loa Loa (eye worm) hypothetical protein 0.0092 0.0828 0.0843
Echinococcus multilocularis dna polymerase eta 0.0022 0.0071 0.0071
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0703 0.7495 0.7635
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0035 0.0211 0.0211
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0353 0.3681 0.375
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0022 0.0069 0.0071
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0353 0.3681 0.375
Entamoeba histolytica hypothetical protein 0.0202 0.2031 1
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0266 0.031
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.029 0.4474
Echinococcus multilocularis neuropeptide s receptor 0.0534 0.5649 0.5649
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0167 0.1646 0.1677
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0049 0.0364 0.0371
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0129 0.1235 0.1235
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0001
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0212 0.0359
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0353 0.3681 0.375
Schistosoma mansoni hypothetical protein 0.0035 0.0212 0.0359
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0071 0.037
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0036 0.0219 0.1765
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0118 0.112 0.8733
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0022 0.0069 0.0071
Entamoeba histolytica hypothetical protein 0.0022 0.0069 0.0339
Echinococcus multilocularis smad 0.0035 0.0212 0.0212
Loa Loa (eye worm) hypothetical protein 0.0022 0.0069 0.0071
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0044 0.0311 0.0526
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0353 0.3681 0.6224
Brugia malayi MH2 domain containing protein 0.0035 0.0212 0.0216
Entamoeba histolytica hypothetical protein 0.0202 0.2031 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0353 0.3681 0.6224
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0167 0.1646 0.2783
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.00809435 1 1
Echinococcus granulosus Ankyrin 0.0033 0.0184 0.0312
Brugia malayi nuclear hormone receptor 0.0353 0.3681 0.375
Brugia malayi Glycosyl hydrolases family 31 protein 0.0016 0.0001 0.0001
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0036 0.0219 0.0963
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0167 0.1646 0.2783
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0025 0.038
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0187 0.1864 0.3152
Loa Loa (eye worm) hypothetical protein 0.0187 0.1864 0.1899
Loa Loa (eye worm) MH1 domain-containing protein 0.0035 0.0212 0.0216
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.00809435 1 1
Entamoeba histolytica hypothetical protein 0.0022 0.0069 0.0339
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0071 0.109
Brugia malayi Nuclear hormone receptor family member nhr-19 0.00809435 1 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0498 0.526 0.526
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0069 0.0117
Brugia malayi Pre-SET motif family protein 0.0101 0.0929 0.0946
Echinococcus multilocularis lamin dm0 0.0092 0.0828 0.0828
Entamoeba histolytica hypothetical protein 0.0022 0.0069 0.0339
Leishmania major protein kinase, putative 0.0071 0.0603 0.4877
Echinococcus multilocularis survival motor neuron protein 1 0.0519 0.549 0.549
Brugia malayi nuclear receptor NHR-88 0.00809435 1 1
Echinococcus multilocularis GPCR, family 2 0.0035 0.0212 0.0212
Brugia malayi hypothetical protein 0.0167 0.1646 0.1677
Loa Loa (eye worm) hypothetical protein 0.0916 0.9817 1
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0033 0.0184 0.0312
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0129 0.1235 0.2089
Brugia malayi Nuclear hormone receptor family member nhr-25 0.00809435 1 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.0491 0.0501
Loa Loa (eye worm) hypothetical protein 0.0187 0.1864 0.1899
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.00427612 0.107081 0.107081
Echinococcus granulosus lamin 0.0092 0.0828 0.14
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0069 0.0117
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.0071 0.0082
Brugia malayi hypothetical protein 0.0519 0.549 0.5592
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0036 0.0219 0.0963
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.0535 0.0535
Leishmania major phosphopantetheinyl transferase-like protein 0.0027 0.0127 0.1024
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0111 0.104 0.1059
Loa Loa (eye worm) cytochrome P450 family protein 0.0121 0.1147 0.1168
Schistosoma mansoni hypothetical protein 0.0106 0.0989 0.1672
Brugia malayi M-phase phosphoprotein, mpp8 0.0116 0.1099 0.112
Echinococcus multilocularis musashi 0.0092 0.0828 0.0828
Onchocerca volvulus Huntingtin homolog 0.0143 0.139 0.1625
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0266 0.045
Loa Loa (eye worm) hypothetical protein 0.0519 0.549 0.5592
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0035 0.0211 0.0356
Loa Loa (eye worm) hypothetical protein 0.0143 0.139 0.1416
Loa Loa (eye worm) hypothetical protein 0.0111 0.104 0.1059
Loa Loa (eye worm) hypothetical protein 0.0167 0.1646 0.1677
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0036 0.0219 0.1561
Echinococcus granulosus mothers against decapentaplegic 5 0.0035 0.0212 0.0358
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0036 0.0219 0.0963
Loa Loa (eye worm) hypothetical protein 0.009 0.081 0.0825
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0069 0.0117
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0129 0.1235 0.6029
Loa Loa (eye worm) hypothetical protein 0.0353 0.3681 0.375
Plasmodium vivax glutathione reductase, putative 0.0052 0.0395 0.4244
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0069 0.0117
Schistosoma mansoni alpha-glucosidase 0.0164 0.1616 0.2733
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.029 0.4474
Schistosoma mansoni hypothetical protein 0.0145 0.1408 0.2381
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0069 0.0117
Echinococcus multilocularis Ankyrin 0.0033 0.0184 0.0184
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0118 0.112 0.8837
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0202 0.2031 0.3434
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0212 0.0359
Trypanosoma brucei unspecified product 0.0022 0.0071 0.109
Onchocerca volvulus 0.0092 0.0828 0.0967
Schistosoma mansoni nuclear hormone receptor 0.00809435 1 1
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0129 0.1235 0.1258
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0353 0.3681 0.6224
Echinococcus granulosus survival motor neuron protein 1 0.0519 0.549 0.9283
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0101 0.0929 0.157
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0036 0.0219 0.1561
Loa Loa (eye worm) hypothetical protein 0.0167 0.1646 0.1677
Schistosoma mansoni hypothetical protein 0.0076 0.0657 0.1111
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0036 0.0219 0.1561
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0353 0.3681 0.375
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0097 0.0889 0.1502
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0025 0.038
Mycobacterium tuberculosis Probable oxidoreductase 0.0132 0.1264 1
Brugia malayi Nuclear hormone receptor-like 1 0.0353 0.3681 0.375
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0353 0.3681 0.3681
Loa Loa (eye worm) hypothetical protein 0.0353 0.3681 0.375
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0092 0.0828 0.0843
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0044 0.0311 0.0311
Giardia lamblia DINP protein human, muc B family 0.0022 0.0071 0.1904
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0035 0.0212 0.0212
Loa Loa (eye worm) hypothetical protein 0.00427612 0.107081 0.107081
Loa Loa (eye worm) hypothetical protein 0.00809435 1 1
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0032 0.0181 0.0185
Loa Loa (eye worm) hypothetical protein 0.0022 0.0069 0.0071
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0069 0.0069
Brugia malayi Nuclear hormone receptor-like 1 0.0187 0.1864 0.1899
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0071 0.109
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0353 0.3681 0.375
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0027 0.0127 0.1352
Schistosoma mansoni hypothetical protein 0.0558 0.5915 1
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0071 0.0603 0.0704
Loa Loa (eye worm) hypothetical protein 0.00427612 0.107081 0.107081
Loa Loa (eye worm) hypothetical protein 0.0167 0.1646 0.1677
Schistosoma mansoni retinoid-x-receptor (RXR) 0.00427612 0.107081 0.107081
Brugia malayi hypothetical protein 0.0134 0.1286 0.131
Loa Loa (eye worm) hypothetical protein 0.0022 0.0069 0.0071
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0084 0.0098
Echinococcus granulosus Nuclear hormone receptor HR96 0.0167 0.1646 0.2783
Brugia malayi MH1 domain containing protein 0.0019 0.0041 0.0041
Brugia malayi follicle stimulating hormone receptor 0.0269 0.2764 0.2815
Echinococcus multilocularis muscleblind protein 0.0164 0.1617 0.1617
Loa Loa (eye worm) hypothetical protein 0.0039 0.0257 0.0262
Echinococcus granulosus retinoic acid receptor rxr beta a 0.00809435 1 1
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0069 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0353 0.3681 0.375
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0025 0.038
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0036 0.0219 0.1561
Brugia malayi Glycosyl hydrolases family 31 protein 0.0042 0.029 0.0295
Loa Loa (eye worm) hypothetical protein 0.0022 0.0069 0.0071
Loa Loa (eye worm) hypothetical protein 0.0071 0.0603 0.0614
Onchocerca volvulus 0.011 0.103 0.1204
Loa Loa (eye worm) hypothetical protein 0.0164 0.1617 0.1648
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0025 0.038
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0353 0.3681 0.375
Echinococcus multilocularis aryl hydrocarbon receptor 0.0071 0.0603 0.0603
Echinococcus granulosus geminin 0.0558 0.5915 1
Schistosoma mansoni nuclear receptor 0.0167 0.1646 0.2783
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0603 0.0704
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0036 0.0219 0.1561
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0035 0.0211 0.3252
Brugia malayi cytochrome P450 0.0036 0.0219 0.0223
Schistosoma mansoni ankyrin 23/unc44 0.0032 0.0181 0.0307
Loa Loa (eye worm) hypothetical protein 0.0174 0.1724 0.1756
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0097 0.0889 0.0905
Echinococcus granulosus nuclear receptor nhr 48 0.0167 0.1646 0.2783
Loa Loa (eye worm) hypothetical protein 0.0353 0.3681 0.375
Loa Loa (eye worm) MH2 domain-containing protein 0.0515 0.5445 0.5546
Brugia malayi conserved hypotetical protein 0.0167 0.1646 0.1677
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.0535 0.4111
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0103 0.0956 0.0956
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0071 0.109
Brugia malayi steroid hormone receptor 0.00809435 1 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0052 0.0395 0.2985
Brugia malayi regulator of G-protein signaling rgs-7 0.0022 0.0069 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0603 0.0704
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0353 0.3681 0.375
Echinococcus multilocularis thyroid hormone receptor alpha 0.00809435 1 1
Brugia malayi hypothetical protein 0.00427612 0.107081 0.107081
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0036 0.0219 0.1561
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0353 0.3681 0.3681
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0035 0.0212 0.0216
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0187 0.1864 0.1864
Trichomonas vaginalis guanylate cyclase, putative 0.0071 0.0603 0.0704
Brugia malayi Ets-domain containing protein 0.0071 0.0604 0.0615
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0353 0.3681 0.6224
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0266 0.12
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0071 0.109
Echinococcus granulosus GA binding protein alpha chain 0.0071 0.0604 0.1021
Brugia malayi ecdysteroid receptor 0.00809435 1 1
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0036 0.0219 0.1561
Loa Loa (eye worm) hypothetical protein 0.0043 0.0293 0.0298
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0036 0.0219 0.1561
Echinococcus multilocularis netrin receptor unc 5 0.0032 0.0181 0.0181
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0071 0.0603 0.0704
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0069 0.0069
Echinococcus multilocularis GA binding protein alpha chain 0.0071 0.0604 0.0604
Loa Loa (eye worm) hypothetical protein 0.0117 0.1102 0.1123
Loa Loa (eye worm) hypothetical protein 0.00427612 0.107081 0.107081
Loa Loa (eye worm) hypothetical protein 0.0076 0.0657 0.0669
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0167 0.1646 0.2783
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0103 0.0956 0.1617
Trypanosoma cruzi DNA polymerase eta, putative 0.0022 0.0071 0.109
Schistosoma mansoni survival motor neuron protein 0.0106 0.0984 0.1663
Brugia malayi Cytochrome P450 family protein 0.0121 0.1147 0.1168
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0212 0.0216
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0025 0.038
Onchocerca volvulus 0.0114 0.1072 0.1252
Echinococcus multilocularis geminin 0.0558 0.5915 0.5915
Loa Loa (eye worm) hypothetical protein 0.0101 0.0929 0.0946
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0035 0.0211 0.3252
Schistosoma mansoni ap endonuclease 0.004 0.0266 0.045
Echinococcus multilocularis 0.0036 0.0219 0.0219
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.00809435 1 1
Brugia malayi Intermediate filament tail domain containing protein 0.0092 0.0828 0.0843
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0353 0.3681 0.375
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0071 0.109
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0027 0.0127 0.0507
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0118 0.112 0.8837
Brugia malayi nuclear receptor RXR 0.0167 0.1646 0.1677
Loa Loa (eye worm) PXA domain-containing protein 0.0022 0.0069 0.0071
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0071 0.0571
Loa Loa (eye worm) hypothetical protein 0.0167 0.1646 0.1677
Schistosoma mansoni lamin 0.0092 0.0828 0.14
Loa Loa (eye worm) hypothetical protein 0.0033 0.0184 0.0188
Brugia malayi bHLH-PAS transcription factor 0.0202 0.2032 0.207
Plasmodium falciparum thioredoxin reductase 0.0052 0.0395 1
Trichomonas vaginalis sucrase-isomaltase, putative 0.0042 0.029 0.0338
Brugia malayi nuclear hormone receptor 0.00809435 1 1
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0266 0.031
Leishmania major cytochrome p450-like protein 0.0036 0.0219 0.1765
Echinococcus multilocularis neuropeptide receptor A26 0.0534 0.5649 0.5649
Brugia malayi hypothetical protein 0.0167 0.1646 0.1677
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.00809435 1 1
Echinococcus granulosus muscleblind protein 0.0164 0.1617 0.2735
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0353 0.3681 0.6224
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0118 0.112 0.8837
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0353 0.3681 0.3681
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0075 0.0647 0.3097
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0167 0.1646 0.1646
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0353 0.3681 0.6224
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0027 0.0127 0.1763
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0069 0.0117
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0167 0.1646 0.1924
Brugia malayi MH2 domain containing protein 0.0035 0.0212 0.0216
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0069 0.0117
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0035 0.0211 0.2255
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0353 0.3681 0.3681
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0071 0.109
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0353 0.3681 0.6224
Echinococcus multilocularis transfer RNA-Lys 0.0202 0.2032 0.2032
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.00809435 1 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0025 0.0199
Schistosoma mansoni hypothetical protein 0.0035 0.0212 0.0359
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0016 0.0001 0.0001
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0129 0.1235 1
Brugia malayi nuclear receptor RXR 0.0187 0.1864 0.1899
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.0041
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0036 0.0219 0.1561
Brugia malayi hypothetical protein 0.0916 0.9817 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0353 0.3681 0.375
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0036 0.0219 0.0963
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0071 0.109
Brugia malayi nuclear receptor RXR 0.00427612 0.107081 0.107081
Loa Loa (eye worm) hypothetical protein 0.00809435 1 1
Brugia malayi Thioredoxin reductase 0.0052 0.0395 0.0402
Brugia malayi intermediate filament protein 0.0092 0.0828 0.0843
Leishmania major protein kinase, putative 0.0071 0.0603 0.4877
Brugia malayi Nuclear hormone receptor family member nhr-40 0.00809435 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.00809435 1 1
Schistosoma mansoni thyroid hormone receptor 0.0498 0.526 0.8894
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.00809435 1 1
Echinococcus multilocularis FTZ F1 alpha 0.00809435 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.00809435 1 1
Schistosoma mansoni Smad4 0.0035 0.0212 0.0358
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0071 0.109
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0036 0.0219 0.3373
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0071 0.012
Brugia malayi Nuclear hormone receptor-like 1 0.00427612 0.107081 0.107081
Brugia malayi Cytochrome P450 family protein 0.0075 0.0647 0.0659
Schistosoma mansoni steroid hormone receptor ad4bp 0.0353 0.3681 0.6224
Schistosoma mansoni retinoic acid receptor RXR 0.0353 0.3681 0.6224
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0132 0.1264 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.00809435 1 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0212 0.0216
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0036 0.0219 0.0963
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0069 0.008
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0022 0.0069 0.0069
Schistosoma mansoni Tr4/Tr2 (homologue) 0.00809435 1 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0071 0.0603 0.9317
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0266 0.4109
Echinococcus granulosus neuropeptide receptor A26 0.0534 0.5649 0.9551
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0101 0.0929 0.157
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0353 0.3681 0.375
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0101 0.0929 1
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0071 0.0603 0.1019
Loa Loa (eye worm) hypothetical protein 0.0167 0.1646 0.1677
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0266 0.6513
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0069 0.008
Loa Loa (eye worm) hypothetical protein 0.0097 0.0889 0.0905
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0036 0.0219 0.3373
Loa Loa (eye worm) hypothetical protein 0.00809435 1 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0167 0.1646 0.1646
Brugia malayi Protein kinase domain containing protein 0.0032 0.0181 0.0185
Schistosoma mansoni hypothetical protein 0.0558 0.5915 1
Schistosoma mansoni aryl hydrocarbon receptor 0.0273 0.2806 0.4745
Brugia malayi Steroid receptor seven-up type 2 0.00809435 1 1
Brugia malayi Steroid receptor seven-up type 2 0.0353 0.3681 0.375
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0036 0.0219 0.1561
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0071 0.0229
Schistosoma mansoni alpha-glucosidase 0.0164 0.1616 0.2733
Trichomonas vaginalis set domain proteins, putative 0.08 0.8554 1
Echinococcus multilocularis beta adrenergic receptor kinase 0.0022 0.0069 0.0069
Echinococcus multilocularis thioredoxin glutathione reductase 0.0052 0.0395 0.0395
Leishmania major cytochrome p450-like protein 0.0036 0.0219 0.1765
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0032 0.0181 0.0307
Schistosoma mansoni nuclear hormone receptor 0.0167 0.1646 0.2783
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0167 0.1646 0.2783
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0036 0.0219 0.1561
Loa Loa (eye worm) cytochrome P450 family protein 0.0075 0.0647 0.0659
Loa Loa (eye worm) RecQ helicase 0.0023 0.0084 0.0086
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0069 0.0117
Onchocerca volvulus 0.0167 0.1646 0.1924
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0071 0.0603 0.9317
Loa Loa (eye worm) hypothetical protein 0.0187 0.1864 0.1899
Echinococcus granulosus aryl hydrocarbon receptor 0.0071 0.0603 0.1019
Echinococcus granulosus intermediate filament protein 0.0092 0.0828 0.14
Echinococcus granulosus death domain containing protein 0.0032 0.0181 0.0307
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0535 0.2538
Schistosoma mansoni hypothetical protein 0.0032 0.0181 0.0307
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0353 0.3681 0.6224
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0071 0.109
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0353 0.3681 0.375
Loa Loa (eye worm) nuclear factor I 0.0019 0.0041 0.0041
Echinococcus granulosus ecdysone induced protein 78C 0.0353 0.3681 0.6224
Schistosoma mansoni hypothetical protein 0.0036 0.0219 0.037
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0071 0.0603 0.9317
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0069 0.0117
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0035 0.0211 0.1702
Brugia malayi hypothetical protein 0.0022 0.0069 0.0071
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0266 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0033 0.0033
Brugia malayi glutathione reductase 0.0052 0.0395 0.0402
Echinococcus multilocularis lysosomal alpha glucosidase 0.019 0.1905 0.1905
Brugia malayi Isocitrate dehydrogenase 0.0035 0.0211 0.0215
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0071 0.109
Plasmodium falciparum glutathione reductase 0.0052 0.0395 1
Leishmania major alpha glucosidase II subunit, putative 0.0042 0.029 0.2342
Trypanosoma brucei cytochrome P450, putative 0.0075 0.0647 1
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0036 0.0219 0.0963
Loa Loa (eye worm) hypothetical protein 0.0353 0.3681 0.375
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0035 0.0211 0.0211
Onchocerca volvulus 0.0071 0.0603 0.0704
Loa Loa (eye worm) hypothetical protein 0.0167 0.1646 0.1677
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.029 0.1424
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0084 0.0084
Loa Loa (eye worm) CYP4Cod1 0.0075 0.0647 0.0659
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0036 0.0219 0.0963
Toxoplasma gondii cytochrome p450 superfamily protein 0.0036 0.0219 0.2141
Loa Loa (eye worm) nuclear hormone receptor 0.0167 0.1646 0.1677
Brugia malayi PAS domain containing protein 0.0273 0.2806 0.2858
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0212 0.0212
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0022 0.0069 0.008
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0071 0.0229
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0035 0.0211 0.0211
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.0535 0.4325
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0071 0.109
Brugia malayi nuclear receptor NHR-67 0.0167 0.1646 0.1677
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.0535 0.5639
Loa Loa (eye worm) hypothetical protein 0.0167 0.1646 0.1677
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0101 0.0929 0.0929
Echinococcus multilocularis Smad4 0.0035 0.0212 0.0212
Brugia malayi Nuclear hormone receptor family member nhr-41 0.00809435 1 1
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0069 0.0117
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0071 0.012
Trichomonas vaginalis maltase-glucoamylase, putative 0.0042 0.029 0.0338
Brugia malayi steroid hormone receptor 0.0353 0.3681 0.375
Mycobacterium leprae Conserved hypothetical protein 0.0036 0.0219 0.0805
Loa Loa (eye worm) hypothetical protein 0.0167 0.1646 0.1677
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0035 0.0211 0.0356
Loa Loa (eye worm) hypothetical protein 0.00809435 1 1
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0535 0.0904
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0022 0.0069 0.0071
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0022 0.0069 0.0117
Onchocerca volvulus Huntingtin homolog 0.0143 0.139 0.1625
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0353 0.3681 0.6224
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.012 0.1141 0.1162
Schistosoma mansoni hypothetical protein 0.0035 0.0212 0.0359
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.0071 0.0082
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0353 0.3681 0.375
Echinococcus multilocularis lamin 0.0092 0.0828 0.0828
Schistosoma mansoni coup transcription factor 0.0353 0.3681 0.6224
Trypanosoma brucei DNA polymerase eta, putative 0.0022 0.0071 0.109
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0069 0.0117
Schistosoma mansoni hypothetical protein 0.0035 0.0212 0.0359
Trypanosoma cruzi cytochrome P450, putative 0.0075 0.0647 1
Schistosoma mansoni zinc finger protein 0.0167 0.1646 0.2783
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0167 0.1646 0.1677
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0071 0.0603 0.9317
Loa Loa (eye worm) hypothetical protein 0.00427612 0.107081 0.107081
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0071 0.0603 0.0704
Plasmodium vivax SET domain protein, putative 0.0101 0.0929 1
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0036 0.0219 0.0963
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.019 0.1905 0.1941
Brugia malayi regulator of G-protein signaling egl-10 0.0022 0.0069 0.0071
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0035 0.0211 0.1497
Brugia malayi Nuclear hormone receptor family member nhr-49 0.00809435 1 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.029 0.0338
Loa Loa (eye worm) hypothetical protein 0.0353 0.3681 0.375
Echinococcus granulosus lysosomal alpha glucosidase 0.019 0.1905 0.3222
Echinococcus granulosus Nuclear hormone receptor HR96 0.0167 0.1646 0.2783
Onchocerca volvulus 0.0106 0.0984 0.115
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.029 0.0338
Echinococcus granulosus smad 0.0035 0.0212 0.0358
Loa Loa (eye worm) hypothetical protein 0.00809435 1 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0035 0.0211 0.0215
Echinococcus multilocularis L aminoadipate semialdehyde 0.0097 0.0889 0.0889
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0036 0.0219 0.0963
Echinococcus multilocularis ecdysone induced protein 78C 0.00809435 1 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0035 0.0212 0.0216
Brugia malayi hypothetical protein 0.0174 0.1724 0.1756
Schistosoma mansoni intermediate filament proteins 0.0092 0.0828 0.14
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0069 0.0117
Schistosoma mansoni steroid hormone receptor ad4bp 0.00809435 1 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0353 0.3681 0.4302
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.00809435 1 1
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0069 0.0071
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0212 0.0212
Loa Loa (eye worm) hypothetical protein 0.0022 0.0069 0.0071
Brugia malayi Smad1 0.0035 0.0212 0.0216
Brugia malayi hypoxia-induced factor 1 0.0845 0.9044 0.9212
Brugia malayi Nuclear hormone receptor family member nhr-31 0.00809435 1 1
Onchocerca volvulus 0.0353 0.3681 0.4302
Entamoeba histolytica hypothetical protein 0.0027 0.0127 0.0623
Trypanosoma brucei hypothetical protein, conserved 0.0027 0.0127 0.1956
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.00809435 1 1
Entamoeba histolytica hypothetical protein 0.0202 0.2031 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.0535 0.0904
Brugia malayi Nuclear hormone receptor family member nhr-14 0.00809435 1 1
Brugia malayi Cytochrome P450 family protein 0.0036 0.0219 0.0223
Onchocerca volvulus Protein ultraspiracle homolog 0.0353 0.3681 0.4302
Brugia malayi nuclear receptor NHR-88 0.0167 0.1646 0.1677
Toxoplasma gondii isocitrate dehydrogenase 0.0035 0.0211 0.2054
Brugia malayi Pre-SET motif family protein 0.0703 0.7495 0.7635
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0025 0.0199
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0071 0.0603 1
Brugia malayi hypothetical protein 0.0187 0.1864 0.1899
Schistosoma mansoni DNA polymerase eta 0.0022 0.0071 0.012
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0025 0.0029
Schistosoma mansoni smad1 5 8 and 0.0035 0.0212 0.0358
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0025 0.0043
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.00809435 1 1
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0069 0.0117
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0036 0.0219 0.0963
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0036 0.0219 0.1561
Brugia malayi ecdysone receptor 0.0167 0.1646 0.1677
Brugia malayi hypothetical protein 0.0187 0.1864 0.1899
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0025 0.0199
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0032 0.0181 0.0181
Echinococcus multilocularis nuclear receptor nhr 48 0.0167 0.1646 0.1646
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.00809435 1 1
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0036 0.0219 0.1561
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0036 0.0219 0.1561
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0071 0.037
Brugia malayi MH1 domain containing protein 0.0019 0.0041 0.0041
Echinococcus granulosus lamin dm0 0.0092 0.0828 0.14
Loa Loa (eye worm) thioredoxin reductase 0.0052 0.0395 0.0402
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0035 0.0211 0.3252
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0036 0.0219 0.0963
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0027 0.0127 0.2753
Brugia malayi ecdysteroid receptor 0.0353 0.3681 0.375
Trypanosoma cruzi cytochrome P450, putative 0.0075 0.0647 1
Echinococcus granulosus Regulator of G protein signaling 20 0.0022 0.0069 0.0117
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0027 0.0127 0.1127
Brugia malayi Fli-1 protein 0.0216 0.2182 0.2222
Onchocerca volvulus Bile acid receptor homolog 0.00809435 1 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.00809435 1 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0035 0.0211 0.0211
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0167 0.1646 0.1646
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0069 0.0069
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0103 0.0956 0.1617
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0071 0.0603 0.0704
Trichomonas vaginalis guanylate cyclase, putative 0.0071 0.0603 0.0704
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0025 0.038
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0353 0.3681 0.6224
Loa Loa (eye worm) steroid hormone receptor 0.00809435 1 1
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0027 0.0127 0.4227
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.0266 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0353 0.3681 0.6224
Loa Loa (eye worm) hypothetical protein 0.0164 0.1617 0.1648
Brugia malayi nuclear hormone receptor family member odr-7 0.0167 0.1646 0.1677
Loa Loa (eye worm) nuclear receptor NHR-67 0.0167 0.1646 0.1677
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0353 0.3681 0.375
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0167 0.1646 0.1924
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0266 0.215
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0084 0.0086
Brugia malayi hypothetical protein 0.0117 0.1102 0.1123
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0132 0.1264 1
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0071 0.0603 0.0603
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0353 0.3681 0.375
Brugia malayi latrophilin 2 splice variant baaae 0.0076 0.0657 0.0669
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.029 0.0338
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0042 0.029 0.2929
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0025 0.038
Loa Loa (eye worm) hypothetical protein 0.0634 0.6744 0.687
Loa Loa (eye worm) Smad1 0.0035 0.0212 0.0216
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0535 0.0904
Echinococcus granulosus thioredoxin glutathione reductase 0.0052 0.0395 0.0668
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0129 0.1235 0.9765
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0027 0.0127 0.0822
Leishmania major DNA polymerase eta, putative 0.0022 0.0071 0.0571
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0027 0.0127 0.4227
Echinococcus granulosus cytochrome P450 2K1 0.0036 0.0219 0.037
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0353 0.3681 0.375
Loa Loa (eye worm) hypothetical protein 0.0022 0.0071 0.0072
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0025 0.0043
Schistosoma mansoni gabp alpha 0.0071 0.0604 0.1021
Echinococcus granulosus Smad4 0.0035 0.0212 0.0358
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0111 0.104 0.1059
Brugia malayi Nuclear hormone receptor E75 0.0167 0.1646 0.1677
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.0266 1
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0069 0.008
Loa Loa (eye worm) hypothetical protein 0.00809435 1 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.029 0.0338
Brugia malayi Cytochrome P450 family protein 0.0075 0.0647 0.0659
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.00427612 0.107081 0.107081
Brugia malayi Calcitonin receptor-like protein seb-1 0.0111 0.104 0.1059
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0069 0.0071
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.00427612 0.107081 0.107081
Schistosoma mansoni ap endonuclease 0.004 0.0266 0.045
Schistosoma mansoni nuclear hormone receptor 0.0353 0.3681 0.6224
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0353 0.3681 0.375
Brugia malayi nuclear hormone receptor family member nhr-6 0.0167 0.1646 0.1677
Onchocerca volvulus Netrin receptor homolog 0.0032 0.0181 0.0212
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0035 0.0211 0.0211
Echinococcus granulosus histone lysine methyltransferase setb 0.0101 0.0929 0.157
Mycobacterium tuberculosis Probable reductase 0.0118 0.112 0.8837
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.00427612 0.107081 0.107081
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0053 0.0764
Echinococcus multilocularis Regulator of G protein signaling 20 0.0022 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0187 0.1864 0.1899
Echinococcus granulosus nuclear receptor 2DBD gamma 0.00809435 1 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.00809435 1 1
Loa Loa (eye worm) hypothetical protein 0.0143 0.139 0.1416
Echinococcus multilocularis muscleblind protein 1 0.0164 0.1617 0.1617
Brugia malayi MH1 domain containing protein 0.0035 0.0212 0.0216
Schistosoma mansoni ets-related 0.0216 0.2182 0.3689
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0129 0.1235 0.6029
Loa Loa (eye worm) hypothetical protein 0.0167 0.1646 0.1677
Loa Loa (eye worm) DR-78 0.0167 0.1646 0.1677
Loa Loa (eye worm) hypothetical protein 0.0167 0.1646 0.1677
Echinococcus multilocularis mothers against decapentaplegic 5 0.0035 0.0212 0.0212
Brugia malayi hypothetical protein 0.0143 0.139 0.1416
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0145 0.1408 0.1408
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0603 0.0704
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.00809435 1 1
Loa Loa (eye worm) hypothetical protein 0.00809435 1 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.00809435 1 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.00809435 1 1
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0027 0.0127 0.1127
Echinococcus granulosus expressed protein 0.0429 0.4511 0.7627
Echinococcus granulosus GPCR family 2 0.0035 0.0212 0.0359
Echinococcus multilocularis regulator of G protein signaling 0.0022 0.0069 0.0069
Entamoeba histolytica hypothetical protein 0.0202 0.2031 1
Onchocerca volvulus 0.0116 0.1099 0.1285
Loa Loa (eye worm) hypothetical protein 0.0167 0.1646 0.1677
Loa Loa (eye worm) hypothetical protein 0.0187 0.1864 0.1899
Echinococcus granulosus FTZ F1 alpha 0.00809435 1 1
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0036 0.0219 0.3373
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0071 0.0603 0.0614
Leishmania major DNA polymerase kappa, putative 0.0022 0.0071 0.0571
Echinococcus multilocularis expressed protein 0.0429 0.4511 0.4511
Echinococcus granulosus ecdysone induced protein 78C 0.00809435 1 1
Echinococcus granulosus dna polymerase kappa 0.0022 0.0071 0.012
Toxoplasma gondii isocitrate dehydrogenase 0.0035 0.0211 0.2054
Brugia malayi cytoplasmic intermediate filament protein 0.0049 0.0364 0.0371
Plasmodium vivax thioredoxin reductase, putative 0.0052 0.0395 0.4244
Loa Loa (eye worm) hypothetical protein 0.0353 0.3681 0.375
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0071 0.0604 0.0615
Echinococcus granulosus dna polymerase eta 0.0022 0.0071 0.012
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0022 0.0069 0.0071
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.029 0.0338
Echinococcus multilocularis lysosomal alpha glucosidase 0.019 0.1905 0.1905
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0353 0.3681 0.6224
Trypanosoma brucei trypanothione reductase 0.0052 0.0395 0.6105
Loa Loa (eye worm) intermediate filament protein 0.0092 0.0828 0.0843
Onchocerca volvulus 0.0092 0.0828 0.0967
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0069 0.0117
Echinococcus granulosus beta-adrenergic receptor kinase 0.0022 0.0069 0.0117
Brugia malayi Nuclear hormone receptor-like 1 0.00809435 1 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.027 uM Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D10 assessed as inhibition of parasite LDH activity after 72 hrs by spectrophotometry ChEMBL. 21396743
IC50 (functional) = 0.062 uM Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 assessed as inhibition of parasite LDH activity after 72 hrs by spectrophotometry ChEMBL. 21396743

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 21396743

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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