Detailed information for compound 156626

Basic information

Technical information
  • TDR Targets ID: 156626
  • Name: (2S)-2-(4,6-dimethylpyrimidin-2-yl)oxy-2-[(5S )-1-[(4-methoxyphenyl)methyl]-2-oxo-5-[3-(tri fluoromethyl)phenyl]-3,4-dihydro-1,4-benzodia zepin-5-yl]acetic acid
  • MW: 606.592 | Formula: C32H29F3N4O5
  • H donors: 2 H acceptors: 5 LogP: 2.75 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccc(cc1)CN1C(=O)CN[C@](c2c1cccc2)(c1cccc(c1)C(F)(F)F)[C@@H](C(=O)O)Oc1nc(C)cc(n1)C
  • InChi: 1S/C32H29F3N4O5/c1-19-15-20(2)38-30(37-19)44-28(29(41)42)31(22-7-6-8-23(16-22)32(33,34)35)25-9-4-5-10-26(25)39(27(40)17-36-31)18-21-11-13-24(43-3)14-12-21/h4-16,28,36H,17-18H2,1-3H3,(H,41,42)/t28-,31+/m1/s1
  • InChiKey: FQXLGGFHDJJJJO-MVSFAKPFSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2S)-2-[(4,6-dimethyl-2-pyrimidinyl)oxy]-2-[(5S)-1-[(4-methoxyphenyl)methyl]-2-oxo-5-[3-(trifluoromethyl)phenyl]-3,4-dihydro-1,4-benzodiazepin-5-yl]acetic acid
  • (2S)-2-(4,6-dimethylpyrimidin-2-yl)oxy-2-[(5S)-1-[(4-methoxyphenyl)methyl]-2-oxo-5-[3-(trifluoromethyl)phenyl]-3,4-dihydro-1,4-benzodiazepin-5-yl]ethanoic acid
  • (2S)-2-(4,6-dimethylpyrimidin-2-yl)oxy-2-[(5S)-2-keto-1-p-anisyl-5-[3-(trifluoromethyl)phenyl]-3,4-dihydro-1,4-benzodiazepin-5-yl]acetic acid
  • (2S)-2-(4,6-dimethylpyrimidin-2-yl)oxy-2-[(5S)-2-keto-1-(4-methoxybenzyl)-5-[3-(trifluoromethyl)phenyl]-3,4-dihydro-1,4-benzodiazepin-5-yl]acetic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens endothelin receptor type B Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis G-protein coupled receptor, putative 0.0012 0.0025 0.0025
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0015 0.0039 0.0039
Onchocerca volvulus 0.004 0.0171 0.059
Brugia malayi Smad1 0.0008 0.0006 0.0015
Loa Loa (eye worm) hypothetical protein 0.0008 0.0006 0.0016
Loa Loa (eye worm) hypothetical protein 0.0022 0.0075 0.0197
Trypanosoma cruzi PAB1-binding protein , putative 0.0018 0.0055 0.013
Onchocerca volvulus 0.001 0.0017 0.0058
Trichomonas vaginalis glutathione reductase, putative 0.0055 0.0244 0.0999
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0066
Mycobacterium ulcerans polyketide synthase Pks13 0.003 0.0119 0.0306
Echinococcus multilocularis pyruvate kinase 0.0018 0.0058 0.0058
Trichomonas vaginalis ran, putative 0.0015 0.0043 0.0157
Schistosoma mansoni neuropeptide receptor 0.0012 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0066
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0012 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0066
Mycobacterium leprae Probable polyketide synthase Pks1 0.0021 0.0074 0.0189
Loa Loa (eye worm) IMP dehydrogenase 1 0.0753 0.3809 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0474 0.2384 1
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0862 0.3598
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0012 0.0025 0.0025
Schistosoma mansoni smad 0.0008 0.0006 0.0006
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.001 0.0014 0.0014
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0075 0.0075
Schistosoma mansoni hypothetical protein 0.0008 0.0005 0.0005
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0055 0.0244 0.0633
Brugia malayi nuclear receptor NHR-88 0.001 0.0017 0.0044
Loa Loa (eye worm) hypothetical protein 0.0025 0.0092 0.024
Loa Loa (eye worm) hypothetical protein 0.0014 0.0034 0.0089
Schistosoma mansoni inositol monophosphatase 0.0052 0.023 0.023
Echinococcus granulosus thyroid hormone receptor alpha 0.001 0.0017 0.0017
Leishmania major trypanothione reductase 0.0158 0.077 0.2008
Trypanosoma brucei NADH dehydrogenase 0.0015 0.0039 0.0086
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0015 0.0043 0.01
Schistosoma mansoni cellular tumor antigen P53 0.0039 0.0166 0.0166
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0012 0.0025 0.0086
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.002 0.0068 0.0114
Entamoeba histolytica hypothetical protein 0.0021 0.0069 0.0267
Brugia malayi Pyruvate kinase, M2 isozyme 0.0036 0.0147 0.0385
Schistosoma mansoni smad1 5 8 and 0.0008 0.0006 0.0006
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0021 0.0069 0.0069
Schistosoma mansoni hypothetical protein 0.0034 0.0139 0.0139
Brugia malayi Serotonin receptor 0.0012 0.0025 0.0066
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0055 0.0244 0.0634
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.004 0.017 0.0445
Echinococcus multilocularis serotonin receptor 0.0012 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0056 0.0249 0.0654
Loa Loa (eye worm) hypothetical protein 0.001 0.0016 0.0042
Mycobacterium leprae Probable cystathionine beta-synthase CBS (Serine sulfhydrase) (Beta-thionase) (Hemoprotein H-450) 0.001 0.0016 0.0036
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0015 0.0039 0.0039
Schistosoma mansoni amine GPCR 0.0012 0.0025 0.0025
Brugia malayi MH1 domain containing protein 0.0008 0.0006 0.0015
Echinococcus multilocularis sex peptide receptor 0.0012 0.0025 0.0025
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0023 0.0084 0.0141
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0066
Echinococcus granulosus pyruvate kinase 0.0018 0.0058 0.0058
Brugia malayi conserved hypotetical protein 0.001 0.0017 0.0044
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0044 0.019 0.032
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0066
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0006 0.0015
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0075 0.0197
Mycobacterium ulcerans aldehyde dehydrogenase 0.0044 0.019 0.0494
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0023 0.0023
Mycobacterium tuberculosis Probable thioesterase TesA 0.0017 0.005 0.0085
Mycobacterium ulcerans Type I modular polyketide synthase 0.002 0.0068 0.0172
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0066
Giardia lamblia Thioredoxin reductase 0.0015 0.0039 0.0095
Brugia malayi nuclear receptor NHR-67 0.001 0.0017 0.0044
Schistosoma mansoni sterol O-acyltransferase 1 0.0083 0.039 0.039
Mycobacterium tuberculosis Probable cystathionine beta-synthase Cbs (serine sulfhydrase) (beta-thionase) (hemoprotein H-450) 0.001 0.0016 0.0027
Brugia malayi ancient conserved domain protein 2 0.001 0.0016 0.0042
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.0569 0.1494
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0008 0.0006 0.0006
Brugia malayi Melatonin receptor type 1A 0.0012 0.0025 0.0066
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0055 0.0244 0.0625
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0021 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0044
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0042 0.018 0.0463
Echinococcus granulosus g protein coupled receptor 0.0012 0.0025 0.0025
Leishmania major hypothetical protein, conserved 0.0015 0.0039 0.0086
Onchocerca volvulus 0.0012 0.0025 0.0086
Loa Loa (eye worm) acyl carrier protein 0.0009 0.0012 0.0031
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0066
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0043 0.0097
Brugia malayi ImpB/MucB/SamB family protein 0.0015 0.0043 0.0113
Echinococcus granulosus tm gpcr rhodopsin 0.0012 0.0025 0.0025
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0043 0.0097
Treponema pallidum thioredoxin reductase (trxB) 0.0015 0.0039 0.0137
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0023 0.006
Treponema pallidum fructose-bisphosphate aldolase 0.0474 0.2384 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0018 0.0057 0.0135
Echinococcus granulosus SNF4:AMP activated protein kinase gamma subunit 0.001 0.0016 0.0016
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.002 0.0068 0.0114
Brugia malayi MBOAT family protein 0.0008 0.0006 0.0016
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0012 0.0025 0.0066
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0008 0.0006 0.0006
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0039 0.0086
Echinococcus multilocularis mitogen activated protein kinase 3 0.0041 0.0172 0.0172
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.003 0.0119 0.02
Onchocerca volvulus 0.0014 0.0038 0.013
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0021 0.0074 0.0125
Echinococcus granulosus mitogen activated protein kinase 3 0.0041 0.0172 0.0172
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0041 0.0172 0.0437
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0066
Echinococcus granulosus pyruvate kinase 0.0018 0.0058 0.0058
Loa Loa (eye worm) TYRA-2 protein 0.0012 0.0025 0.0066
Mycobacterium leprae Polyketide synthase Pks13 0.003 0.0119 0.0306
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0015 0.0039 0.0137
Loa Loa (eye worm) melatonin receptor type 1A 0.0012 0.0025 0.0066
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.0075 0.0259
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0043 0.0097
Giardia lamblia Pyruvate kinase 0.0018 0.0058 0.0177
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0014 0.0037 0.0062
Schistosoma mansoni neuropeptide F-like receptor 0.0012 0.0025 0.0025
Trypanosoma cruzi trypanothione reductase, putative 0.0158 0.077 0.2008
Echinococcus multilocularis neuropeptides capa receptor 0.0012 0.0025 0.0025
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0023 0.0084 0.0084
Brugia malayi Inositol-1 0.0052 0.023 0.0604
Loa Loa (eye worm) apoptosis regulator protein 0.0034 0.0139 0.0364
Schistosoma mansoni neuropeptide receptor 0.0012 0.0025 0.0025
Echinococcus granulosus neuropeptide receptor 0.0012 0.0025 0.0025
Echinococcus granulosus dna polymerase kappa 0.0015 0.0043 0.0043
Treponema pallidum NADH oxidase 0.0055 0.0244 0.0999
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0415 0.2082 0.5463
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0055 0.0244 0.0625
Loa Loa (eye worm) hypothetical protein 0.001 0.0016 0.0042
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0015 0.0039 0.0096
Echinococcus multilocularis neuropeptide receptor 0.0012 0.0025 0.0025
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0015 0.0039 0.0087
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0066
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0055 0.0244 0.0625
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0015 0.0039 0.0086
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0082 0.0384 0.0384
Echinococcus granulosus glutamate synthase 0.0015 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0032 0.013 0.0341
Loa Loa (eye worm) HMP-2 protein 0.0043 0.0186 0.0487
Trichomonas vaginalis glucosylceramidase, putative 0.0115 0.0553 0.2301
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0066
Echinococcus multilocularis dro:myosuppressin receptor 0.0012 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.006
Onchocerca volvulus 0.0103 0.049 0.1687
Schistosoma mansoni ap endonuclease 0.0014 0.0037 0.0037
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0075 0.0197
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0015 0.0039 0.0096
Mycobacterium ulcerans aldehyde dehydrogenase 0.0044 0.019 0.0494
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0006 0.0006
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0023 0.0084 0.0204
Brugia malayi HSF-type DNA-binding domain containing protein 0.0057 0.0254 0.0666
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0008 0.0005 0.0005
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0015 0.0039 0.0086
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0008 0.0006 0.0006
Trypanosoma cruzi PAB1-binding protein , putative 0.0018 0.0055 0.013
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0015 0.0039 0.0059
Mycobacterium ulcerans ferredoxin reductase 0.0015 0.0039 0.0096
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0055 0.0244 0.0625
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0066
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0753 0.3809 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0013 0.003 0.0051
Echinococcus multilocularis Niemann Pick C1 protein 0.0075 0.035 0.035
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0008 0.0006 0.0016
Brugia malayi loechrig isoform VII 0.001 0.0016 0.0042
Toxoplasma gondii IMP dehydrogenas 0.0753 0.3809 1
Onchocerca volvulus Cirhin homolog 0.0043 0.0184 0.0635
Brugia malayi G protein-coupled receptor 0.0012 0.0025 0.0066
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0147 0.0385
Loa Loa (eye worm) hypothetical protein 0.0022 0.0075 0.0197
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0008 0.0006 0.0006
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0122 0.0589 0.1541
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0015 0.0043 0.0098
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0036 0.0147 0.0247
Loa Loa (eye worm) hypothetical protein 0.0245 0.1214 0.3186
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0021 0.0074 0.0189
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0044
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0015 0.0039 0.0065
Echinococcus granulosus biogenic amine 5HT receptor 0.0012 0.0025 0.0025
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0075 0.0075
Leishmania major pyruvate kinase 0.0036 0.0147 0.037
Echinococcus granulosus importin subunit beta 1 0.0021 0.0072 0.0072
Mycobacterium ulcerans thioesterase 0.0017 0.005 0.0127
Brugia malayi Voltage gated chloride channel family protein 0.001 0.0016 0.0042
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.003 0.012 0.0315
Trichomonas vaginalis glucosylceramidase, putative 0.0115 0.0553 0.2301
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0022 0.0077 0.0077
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0056 0.0249 0.0249
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0052 0.023 0.0564
Echinococcus multilocularis microtubule associated protein 2 0.1966 1 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0075 0.0075
Entamoeba histolytica acyl-CoA synthetase, putative 0.002 0.0068 0.026
Echinococcus granulosus serotonin receptor 0.0012 0.0025 0.0025
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0066
Onchocerca volvulus 0.0015 0.0044 0.015
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0172 0.0172
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0122 0.0589 0.4438
Schistosoma mansoni ap endonuclease 0.0014 0.0037 0.0037
Echinococcus multilocularis g protein coupled receptor 0.0012 0.0025 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0075 0.0197
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0017 0.0049 0.0082
Brugia malayi Pre-SET motif family protein 0.0153 0.0747 0.1962
Loa Loa (eye worm) hypothetical protein 0.0008 0.0006 0.0016
Entamoeba histolytica hypothetical protein 0.0017 0.0051 0.0191
Chlamydia trachomatis thioredoxin reductase 0.0015 0.0039 0.0175
Schistosoma mansoni biogenic amine (5HT) receptor 0.0012 0.0025 0.0025
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0015 0.0039 0.0065
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0753 0.3809 1
Schistosoma mansoni single-minded 0.0021 0.0071 0.0071
Brugia malayi MH2 domain containing protein 0.0008 0.0006 0.0015
Echinococcus multilocularis g protein coupled receptor 0.0012 0.0025 0.0025
Trypanosoma brucei unspecified product 0.0015 0.0043 0.0097
Echinococcus granulosus mitogen activated protein kinase 0.0041 0.0172 0.0172
Loa Loa (eye worm) hhat protein 0.0008 0.0006 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0075 0.0197
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0066
Mycobacterium ulcerans putative regulatory protein 0.0015 0.0044 0.0109
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0012 0.0025 0.0066
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0075 0.0075
Brugia malayi Matrixin family protein 0.001 0.0014 0.0037
Echinococcus granulosus G protein coupled receptor 139 0.0012 0.0025 0.0025
Schistosoma mansoni myosin xvIII 0.0012 0.0025 0.0025
Plasmodium falciparum subtilisin-like protease 1 0.0073 0.0338 0.0886
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0075 0.0075
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0157 0.0767 0.2
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0015 0.0039 0.0137
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0023 0.0084 0.0084
Brugia malayi AMP-binding enzyme family protein 0.0018 0.0057 0.0151
Trypanosoma cruzi DNA polymerase kappa, putative 0.0015 0.0043 0.0097
Trichomonas vaginalis set domain proteins, putative 0.0174 0.0855 0.3571
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0015 0.0039 0.0137
Onchocerca volvulus 0.001 0.0017 0.0058
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0474 0.2384 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0097 0.046 0.0774
Echinococcus granulosus H:Cl exchange transporter 3 0.001 0.0016 0.0016
Toxoplasma gondii HEAT repeat-containing protein 0.0021 0.0072 0.0173
Toxoplasma gondii chloride transporter, chloride channel (ClC) family protein 0.001 0.0016 0.0026
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0055 0.0244 0.06
Echinococcus multilocularis H(+):Cl() exchange transporter 3 0.001 0.0016 0.0016
Echinococcus granulosus o acyltransferase membrane bound domain 0.0008 0.0006 0.0006
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0017 0.0051 0.0191
Brugia malayi hypothetical protein 0.007 0.0323 0.0847
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0012 0.0025 0.0025
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0013 0.0031 0.0067
Echinococcus granulosus H:Cl exchange transporter 4 0.001 0.0016 0.0016
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.002 0.0068 0.0172
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0013 0.003 0.0051
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0075 0.0075
Echinococcus granulosus T cell transcription factor 4 long C terminal 0.0029 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0066
Schistosoma mansoni amine GPCR 0.0012 0.0025 0.0025
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0025 0.0025
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0016 0.0047 0.0119
Schistosoma mansoni pyruvate kinase 0.0036 0.0147 0.0147
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0066
Brugia malayi Nuclear hormone receptor E75 0.001 0.0017 0.0044
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0011 0.0023 0.0039
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0147 0.0385
Chlamydia trachomatis replicative DNA helicase 0.0263 0.1307 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0122 0.0589 0.1533
Entamoeba histolytica acyl-coA synthetase, putative 0.0018 0.0057 0.0216
Loa Loa (eye worm) glutathione reductase 0.0158 0.077 0.2021
Schistosoma mansoni inositol monophosphatase 0.0052 0.023 0.023
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0015 0.0043 0.0114
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0018 0.0057 0.0097
Echinococcus multilocularis neuropeptide s receptor 0.1006 0.51 0.51
Entamoeba histolytica heat shock transcription factor, putative 0.0057 0.0254 0.1041
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0015 0.0039 0.0095
Echinococcus granulosus hypothetical protein 0.0134 0.0649 0.0649
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0023 0.006
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0047 0.0202 0.0526
Trypanosoma brucei protein kinase, putative 0.0041 0.0172 0.0437
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0012 0.0025 0.0042
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0015 0.0039 0.0087
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0075 0.0197
Trypanosoma brucei importin beta-1 subunit, putative 0.0021 0.0072 0.0173
Brugia malayi glutamate synthase 0.0015 0.0039 0.0101
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0013 0.003 0.0051
Trichomonas vaginalis glucosylceramidase, putative 0.0115 0.0553 0.2301
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0097 0.046 0.1202
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0041 0.0172 0.0437
Trypanosoma cruzi DNA polymerase eta, putative 0.0015 0.0043 0.0097
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0104 0.0494 0.0494
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.006
Leishmania major 4-coumarate:coa ligase-like protein 0.0018 0.0057 0.0135
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0025 0.0025
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0057 0.0097
Schistosoma mansoni hypothetical protein 0.0012 0.0025 0.0025
Loa Loa (eye worm) hhat protein 0.0008 0.0006 0.0016
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0015 0.0039 0.0137
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0055 0.0244 0.0625
Trypanosoma brucei pyruvate kinase 1 0.0036 0.0147 0.037
Schistosoma mansoni hypothetical protein 0.0056 0.0249 0.0249
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0338 0.1692 0.4438
Trypanosoma brucei pyruvate kinase 1, putative 0.0036 0.0147 0.037
Onchocerca volvulus 0.0024 0.0088 0.0304
Trypanosoma brucei DNA polymerase IV, putative 0.0015 0.0043 0.0097
Brugia malayi hypothetical protein 0.0012 0.0025 0.0066
Brugia malayi Hemopexin family protein 0.0014 0.0035 0.0092
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.006
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0056 0.0249 0.0249
Leishmania major hypothetical protein, conserved 0.0015 0.0039 0.0086
Schistosoma mansoni apoptosis regulator bax 0.0034 0.0139 0.0139
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0041 0.0172 0.0437
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0044
Brugia malayi bHLH-PAS transcription factor 0.0015 0.0044 0.0114
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0122 0.0589 0.4438
Plasmodium falciparum ataxin-2 like protein, putative 0.0018 0.0055 0.0132
Plasmodium falciparum ataxin-2 like protein, putative 0.0018 0.0055 0.0132
Echinococcus multilocularis beta catenin 0.0043 0.0186 0.0186
Onchocerca volvulus Fatty acid synthase homolog 0.0036 0.015 0.0518
Echinococcus granulosus neuropeptide receptor A26 0.1006 0.51 0.51
Brugia malayi hypothetical protein 0.0011 0.0023 0.006
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0015 0.0039 0.0087
Schistosoma mansoni hypothetical protein 0.0105 0.0503 0.0503
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0055 0.0244 0.0634
Brugia malayi G-protein coupled receptor 0.0012 0.0025 0.0066
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0753 0.3809 1
Mycobacterium ulcerans DNA polymerase IV 0.0015 0.0043 0.0107
Mycobacterium ulcerans dehydrogenase 0.0015 0.0039 0.0096
Trypanosoma brucei trypanothione reductase 0.0158 0.077 0.2008
Brugia malayi neuropeptide F receptor 0.0012 0.0025 0.0066
Echinococcus multilocularis allatostatin A receptor 0.0012 0.0025 0.0025
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.003 0.012 0.0315
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0075 0.035 0.1446
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0025 0.0025
Schistosoma mansoni amine GPCR 0.0012 0.0025 0.0025
Plasmodium falciparum thioredoxin reductase 0.0055 0.0244 0.0633
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0158 0.077 0.1295
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0055 0.0244 0.0625
Onchocerca volvulus 0.0012 0.0025 0.0086
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0007 0.0002 0.0004
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0015 0.0039 0.0065
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0043 0.0097
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0023 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0075 0.0197
Toxoplasma gondii NADPH-glutathione reductase 0.0055 0.0244 0.0625
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0066
Schistosoma mansoni glutamate synthase 0.0015 0.0039 0.0039
Echinococcus granulosus neuropeptide Y receptor 0.0012 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0066
Trypanosoma brucei importin beta-1 subunit, putative 0.0021 0.0072 0.0173
Brugia malayi larval opioid receptor 0.0012 0.0025 0.0066
Trichomonas vaginalis CMGC family protein kinase 0.0041 0.0172 0.0699
Trypanosoma brucei DNA polymerase kappa, putative 0.0011 0.0019 0.0033
Loa Loa (eye worm) MBOAT family protein 0.0008 0.0006 0.0016
Onchocerca volvulus 0.0012 0.0025 0.0086
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0012 0.0025 0.0025
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0014 0.0037 0.0055
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0015 0.0043 0.0073
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.008 0.0374 0.0629
Leishmania major CBS domain protein, conserved 0.001 0.0016 0.0026
Echinococcus granulosus neuropeptide s receptor 0.1006 0.51 0.51
Loa Loa (eye worm) hypothetical protein 0.0022 0.0075 0.0197
Brugia malayi Importin beta-1 subunit 0.0021 0.0072 0.0188
Echinococcus multilocularis serotonin receptor 0.0012 0.0025 0.0025
Trypanosoma brucei DNA polymerase IV, putative 0.0015 0.0043 0.0097
Leishmania major NADH dehydrogenase, putative 0.0015 0.0039 0.0086
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0015 0.0039 0.0096
Trypanosoma brucei DNA polymerase kappa, putative 0.0011 0.0019 0.0033
Schistosoma mansoni nuclear hormone receptor 0.001 0.0017 0.0017
Mycobacterium tuberculosis Polyketide synthase Pks13 0.003 0.0119 0.02
Mycobacterium ulcerans cystathionine beta-synthase 0.001 0.0016 0.0036
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0088 0.0231
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0753 0.3809 1
Plasmodium vivax thioredoxin reductase, putative 0.0158 0.077 0.2036
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0097 0.046 0.0774
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0055 0.0244 0.0633
Echinococcus multilocularis pyruvate kinase 0.0018 0.0058 0.0058
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0474 0.2384 1
Schistosoma mansoni Replicative DNA helicase 0.0263 0.1307 0.1307
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0097 0.046 0.0774
Loa Loa (eye worm) hypothetical protein 0.0018 0.0057 0.0151
Mycobacterium ulcerans aldehyde dehydrogenase 0.0044 0.019 0.0494
Schistosoma mansoni zinc finger protein 0.0008 0.0006 0.0006
Echinococcus granulosus beta catenin 0.0043 0.0186 0.0186
Mycobacterium ulcerans monoxygenase 0.0015 0.0039 0.0096
Brugia malayi follicle stimulating hormone receptor 0.0195 0.0961 0.2523
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0016 0.0047 0.0119
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0000046644 0.0000065936
Treponema pallidum oxidoreductase 0.0015 0.0039 0.0137
Echinococcus multilocularis geminin 0.0212 0.1047 0.1047
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0014 0.0039 0.0065
Brugia malayi AMP-binding enzyme family protein 0.0018 0.0057 0.0151
Brugia malayi G-protein coupled receptor 0.0012 0.0025 0.0066
Schistosoma mansoni DNA polymerase eta 0.0015 0.0043 0.0043
Schistosoma mansoni aldehyde dehydrogenase 0.0044 0.019 0.019
Trichomonas vaginalis glucosylceramidase, putative 0.0115 0.0553 0.2301
Echinococcus multilocularis neuropeptide FF receptor 2 0.0012 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0066
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.003 0.012 0.0478
Toxoplasma gondii CBS domain-containing protein 0.001 0.0016 0.0026
Toxoplasma gondii RNA-directed DNA polymerase 0.0157 0.0767 0.2
Loa Loa (eye worm) hypothetical protein 0.0013 0.003 0.0078
Echinococcus granulosus peptidase Clp S14 family 0.008 0.0374 0.0374
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0018 0.0057 0.0145
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0014 0.0034 0.0083
Schistosoma mansoni hypothetical protein 0.0014 0.0035 0.0035
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0012 0.0025 0.0066
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0147 0.0505
Echinococcus granulosus neuropeptide FF receptor 2 0.0012 0.0025 0.0025
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0622 0.3139 0.3139
Echinococcus multilocularis fmrfamide receptor 0.0012 0.0025 0.0025
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0015 0.0039 0.0101
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0025 0.0025
Trypanosoma brucei Voltage-gated Chloride channel Like 3 0.001 0.0016 0.0026
Mycobacterium tuberculosis Probable oxidoreductase 0.0137 0.0665 0.1119
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0014 0.0037 0.0081
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0082 0.0384 0.0384
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0014 0.0037 0.0088
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0043 0.0097
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0034 0.0139 0.0364
Echinococcus multilocularis SNF4:AMP activated protein kinase gamma subunit 0.001 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0083 0.039 0.1023
Echinococcus granulosus expressed conserved protein 0.0071 0.0327 0.0327
Plasmodium falciparum telomerase reverse transcriptase 0.0157 0.0767 0.2027
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0066
Schistosoma mansoni adenoreceptor 0.0012 0.0025 0.0025
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0015 0.0043 0.0098
Echinococcus granulosus peptide allatostatin:somatostatin 0.0012 0.0025 0.0025
Leishmania major chloride channel protein, putative 0.001 0.0016 0.0026
Plasmodium vivax pyruvate kinase, putative 0.0036 0.0147 0.0375
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0012 0.0025 0.0025
Plasmodium vivax SET domain protein, putative 0.0022 0.0077 0.0189
Chlamydia trachomatis pyruvate kinase 0.0036 0.0147 0.1011
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0041 0.0172 0.0452
Echinococcus multilocularis g protein coupled receptor 0.0012 0.0025 0.0025
Loa Loa (eye worm) nuclear receptor NHR-67 0.001 0.0017 0.0044
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0043 0.0097
Onchocerca volvulus 0.0012 0.0025 0.0086
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.003 0.012 0.012
Brugia malayi chloride channel protein 7 0.001 0.0016 0.0042
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0012 0.0025 0.0025
Echinococcus granulosus tumor protein p63 0.0269 0.134 0.134
Plasmodium falciparum acyl-CoA synthetase 0.0014 0.0034 0.0074
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0013 0.003 0.0051
Echinococcus granulosus inositol monophosphatase 1 0.0052 0.023 0.023
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0015 0.0039 0.0096
Trypanosoma cruzi chloride channel protein, putative 0.001 0.0016 0.0026
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0075 0.0075
Schistosoma mansoni beta-catenin 0.0043 0.0186 0.0186
Onchocerca volvulus 0.0012 0.0025 0.0086
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0015 0.0039 0.0039
Echinococcus multilocularis pyruvate kinase 0.0036 0.0147 0.0147
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0012 0.0025 0.0066
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0044
Plasmodium vivax pyruvate kinase 2, putative 0.0018 0.0058 0.0138
Echinococcus granulosus alpha 1A adrenergic receptor 0.0012 0.0025 0.0025
Plasmodium vivax ferrodoxin reductase, putative 0.0015 0.0039 0.0087
Mycobacterium tuberculosis Conserved protein 0.001 0.0016 0.0027
Leishmania major pyruvate kinase 0.0036 0.0147 0.037
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0015 0.0043 0.0098
Mycobacterium tuberculosis Probable replicative DNA helicase DnaB 0.1171 0.5943 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0018 0.0057 0.0145
Mycobacterium tuberculosis Conserved protein 0.001 0.0016 0.0027
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0006 0.0006
Leishmania major hypothetical protein, conserved 0.001 0.0016 0.0026
Mycobacterium ulcerans hypothetical protein 0.0018 0.0057 0.0145
Echinococcus granulosus allatostatin A receptor 0.0012 0.0025 0.0025
Entamoeba histolytica disulphide oxidoreductase, putative 0.0015 0.0039 0.0137
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0052 0.023 0.0599
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0016 0.0047 0.0119
Loa Loa (eye worm) matrixin family protein 0.0023 0.0084 0.0222
Giardia lamblia NADH oxidase lateral transfer candidate 0.0055 0.0244 0.0961
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0075 0.0075
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0015 0.0039 0.0096
Loa Loa (eye worm) inositol-1 0.0052 0.023 0.0604
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0014 0.0037 0.0097
Loa Loa (eye worm) matrix metalloproteinase 0.001 0.0014 0.0037
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0025 0.0025
Brugia malayi AMP-binding enzyme family protein 0.0018 0.0057 0.0151
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0014 0.0037 0.0037
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0008 0.0006 0.0006
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.0002 0.0006
Mycobacterium tuberculosis Conserved protein 0.001 0.0016 0.0027
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0025 0.0025
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0055 0.0244 0.0634
Schistosoma mansoni opsin-like receptor 0.0012 0.0025 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0075 0.0197
Mycobacterium tuberculosis Probable reductase 0.0097 0.046 0.0774
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0057 0.0145
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0015 0.0039 0.0086
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0015 0.0039 0.0096
Onchocerca volvulus Matrilysin homolog 0.0022 0.0075 0.0257
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0075 0.0197
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.003 0.012 0.012
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.003 0.012 0.0299
Brugia malayi Dopamine receptor protein 1 0.0012 0.0025 0.0066
Brugia malayi nuclear receptor RXR 0.0011 0.0023 0.006
Schistosoma mansoni neuropeptide F-like receptor 0.0012 0.0025 0.0025
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0015 0.0039 0.0086
Plasmodium vivax glutathione reductase, putative 0.0158 0.077 0.2036
Trichomonas vaginalis DNA polymerase eta, putative 0.0015 0.0043 0.0156
Echinococcus multilocularis mitogen activated protein kinase 0.0041 0.0172 0.0172
Brugia malayi ancient conserved domain protein 4 0.001 0.0016 0.0042
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0338 0.1692 0.4438
Schistosoma mansoni aryl hydrocarbon receptor 0.0021 0.0071 0.0071
Echinococcus granulosus sex peptide receptor 0.0012 0.0025 0.0025
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0025 0.0025
Schistosoma mansoni chloride channel protein 0.001 0.0016 0.0016
Echinococcus multilocularis neuropeptide Y receptor 0.0012 0.0025 0.0025
Onchocerca volvulus 0.0012 0.0025 0.0086
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0753 0.3809 0.3809
Mycobacterium ulcerans hypothetical protein 0.001 0.0016 0.0036
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0012 0.0025 0.0025
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.003 0.012 0.012
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.001 0.0016 0.0016
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0055 0.0244 0.0625
Onchocerca volvulus 0.0039 0.0166 0.0572
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0122 0.0589 0.1541
Brugia malayi Pyruvate kinase, muscle isozyme 0.0036 0.0147 0.0385
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0122 0.0589 0.1541
Brugia malayi G protein-coupled receptor F59B2.13 0.0012 0.0025 0.0066
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0066
Brugia malayi hypothetical protein 0.0011 0.0023 0.006
Brugia malayi Matrixin family protein 0.001 0.0014 0.0037
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0023 0.0084 0.0084
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0023 0.0023
Trypanosoma brucei PAB1-binding protein , putative 0.0018 0.0055 0.013
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0018 0.0057 0.0145
Onchocerca volvulus 0.0012 0.0025 0.0086
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0021 0.0074 0.0189
Onchocerca volvulus Neuropeptide F receptor homolog 0.0012 0.0025 0.0086
Loa Loa (eye worm) hypothetical protein 0.0013 0.003 0.0078
Loa Loa (eye worm) pyruvate kinase-PB 0.0025 0.0092 0.024
Trichomonas vaginalis glutamate synthase, putative 0.0015 0.0039 0.0137
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0012 0.0025 0.0025
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0015 0.0043 0.0115
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0008 0.0006 0.0006
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0116 0.0558 0.1466
Echinococcus granulosus GTP binding nuclear protein Ran 0.0015 0.0043 0.0043
Plasmodium falciparum glutathione reductase 0.0055 0.0244 0.0633
Onchocerca volvulus 0.0012 0.0025 0.0086
Treponema pallidum Mg2+ transport protein (mgtE) 0.001 0.0016 0.0042
Brugia malayi PAS domain containing protein 0.0021 0.0071 0.0187
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0055 0.0244 0.1762
Echinococcus granulosus fmrfamide receptor 0.0012 0.0025 0.0025
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0137 0.0665 0.1741
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0015 0.0039 0.0101
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0012 0.0025 0.0025
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0023 0.0084 0.0084
Toxoplasma gondii CBS family protein 0.001 0.0016 0.0026
Echinococcus granulosus o acyltransferase membrane bound domain 0.0008 0.0006 0.0006
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0012 0.0025 0.0025
Echinococcus multilocularis sterol O acyltransferase 1 0.0083 0.039 0.039
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0122 0.0589 0.2451
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0012 0.0025 0.0025
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0014 0.0037 0.0091
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0147 0.0505
Loa Loa (eye worm) hypothetical protein 0.0022 0.0075 0.0197
Loa Loa (eye worm) hypothetical protein 0.0022 0.0075 0.0197
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.003 0.012 0.0299
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0012 0.0025 0.0066
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0066
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.001 0.0017 0.0017
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0012 0.0025 0.0066
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0066
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0006 0.0006
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0052 0.023 0.0589
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0021 0.0074 0.0189
Trypanosoma brucei telomerase reverse transcriptase 0.0157 0.0767 0.2
Trypanosoma brucei ubiquitin-protein ligase, putative 0.003 0.012 0.0299
Echinococcus granulosus muscleblind protein 0.0223 0.1104 0.1104
Loa Loa (eye worm) DR-78 0.001 0.0017 0.0044
Echinococcus granulosus GPCR family 2 0.0056 0.0249 0.0249
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0038 0.016 0.042
Trypanosoma brucei DNA polymerase eta, putative 0.0015 0.0043 0.0097
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0011 0.002 0.0038
Brugia malayi nuclear hormone receptor 0.001 0.0017 0.0044
Brugia malayi Dopamine receptor 0.0012 0.0025 0.0066
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0043 0.0097
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0025 0.0025
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0224 0.1108 0.2909
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0017 0.0017
Trypanosoma cruzi Domain of unknown function DUF21, putative 0.001 0.0016 0.0026
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0015 0.004 0.0105
Plasmodium falciparum protein MAM3, putative 0.001 0.0016 0.0027
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0474 0.2384 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0075 0.0197
Schistosoma mansoni biogenic amine receptor 0.0012 0.0025 0.0025
Echinococcus multilocularis importin subunit beta 1 0.0021 0.0072 0.0072
Echinococcus granulosus g protein coupled receptor 0.0012 0.0025 0.0025
Brugia malayi Matrixin family protein 0.0023 0.0084 0.0222
Brugia malayi nuclear hormone receptor family member nhr-6 0.001 0.0017 0.0044
Leishmania major DNA polymerase eta, putative 0.0015 0.0043 0.0097
Schistosoma mansoni hypothetical protein 0.0012 0.0025 0.0025
Trichomonas vaginalis glucosylceramidase, putative 0.0115 0.0553 0.2301
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.001 0.0017 0.0017
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.001 0.0016 0.0027
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0015 0.0039 0.0137
Plasmodium falciparum pyruvate kinase 0.0036 0.0147 0.0375
Toxoplasma gondii isocitrate dehydrogenase 0.0023 0.0084 0.0204
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0232 0.1149 0.1149
Trichomonas vaginalis apoptosis inducing factor, putative 0.0015 0.0039 0.0137
Loa Loa (eye worm) hypothetical protein 0.0014 0.0034 0.0089
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0328 0.164 0.4306
Schistosoma mansoni hypothetical protein 0.0021 0.0069 0.0069
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0015 0.0039 0.0086
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0022 0.0077 0.0077
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0075 0.0075
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0075 0.0075
Trichomonas vaginalis ap endonuclease, putative 0.0014 0.0037 0.0129
Echinococcus granulosus neuropeptides capa receptor 0.0012 0.0025 0.0025
Brugia malayi Thioredoxin reductase 0.0158 0.077 0.2021
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0474 0.2384 1
Echinococcus multilocularis G protein coupled receptor 139 0.0012 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0066
Mycobacterium tuberculosis Polyketide synthase Pks2 0.002 0.0064 0.0108
Brugia malayi ImpB/MucB/SamB family protein 0.0015 0.0043 0.0113
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0075 0.0075
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0015 0.0043 0.0114
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0075 0.0075
Echinococcus multilocularis smad 0.0008 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0122 0.0589 0.1546
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.001 0.0017 0.0058
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0263 0.1307 0.3404
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0014 0.0037 0.0082
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0176 0.0864 0.227
Loa Loa (eye worm) hypothetical protein 0.001 0.0016 0.0042
Loa Loa (eye worm) neuropeptide F receptor 0.0012 0.0025 0.0066
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0044 0.019 0.0484
Brugia malayi MBOAT family protein 0.0008 0.0006 0.0016
Loa Loa (eye worm) latrophilin receptor protein 2 0.0056 0.0249 0.0654
Giardia lamblia Pyruvate kinase 0.0036 0.0147 0.0551
Loa Loa (eye worm) hypothetical protein 0.0022 0.0075 0.0197
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0075 0.0197
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0753 0.3809 0.6409
Echinococcus multilocularis glutamate synthase 0.0015 0.0039 0.0039
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0015 0.0039 0.0039
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0015 0.0043 0.0043
Entamoeba histolytica heat shock transcription factor, putative 0.0057 0.0254 0.1041
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.001 0.0016 0.0016
Brugia malayi hypothetical protein 0.0012 0.0025 0.0066
Trypanosoma cruzi GMP reductase 0.0753 0.3809 1
Brugia malayi MBOAT family protein 0.0008 0.0006 0.0016
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0015 0.0039 0.0059
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0122 0.0589 0.1533
Loa Loa (eye worm) hypothetical protein 0.0022 0.0077 0.0202
Trypanosoma cruzi NADH dehydrogenase, putative 0.0015 0.0039 0.0086
Schistosoma mansoni chloride channel protein 0.001 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.0224 0.1108 0.1108
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0862 0.3598
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0075 0.0348 0.0914
Echinococcus multilocularis pyruvate kinase 0.0018 0.0058 0.0058
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0011 0.002 0.0052
Brugia malayi Isocitrate dehydrogenase 0.0023 0.0084 0.022
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0013 0.0033 0.008
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0012 0.0025 0.0025
Loa Loa (eye worm) GMP reductase 0.0328 0.164 0.4306
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0042 0.018 0.073
Plasmodium vivax importin-beta 2, putative 0.0021 0.0072 0.0175
Giardia lamblia DINP protein human, muc B family 0.0015 0.0043 0.0114
Loa Loa (eye worm) hypothetical protein 0.001 0.0014 0.0037
Mycobacterium leprae Conserved hypothetical protein 0.0345 0.1724 0.4522
Toxoplasma gondii CBS domain-containing protein 0.001 0.0016 0.0026
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0066
Loa Loa (eye worm) twinkle helicase 0.0075 0.0348 0.0914
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0008 0.0006 0.0006
Trypanosoma brucei GMP reductase 0.0753 0.3809 1
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0176 0.0862 0.2262
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0015 0.0043 0.01
Schistosoma mansoni ran 0.0015 0.0043 0.0043
Echinococcus multilocularis g-protein coupled receptor 0.0012 0.0025 0.0025
Loa Loa (eye worm) hypoxia-induced factor 1 0.0065 0.0295 0.0774
Echinococcus granulosus orexin receptor type 2 0.0012 0.0025 0.0025
Leishmania major chloride channel protein, putative 0.001 0.0016 0.0026
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0015 0.0039 0.0096
Echinococcus granulosus snurportin 1 0.0224 0.1108 0.1108
Echinococcus multilocularis transfer RNA-Lys 0.0015 0.0044 0.0044
Trypanosoma cruzi DNA polymerase kappa, putative 0.0015 0.0043 0.0097
Loa Loa (eye worm) hypothetical protein 0.0035 0.0141 0.0371
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0066
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0024 0.0088 0.0148
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0043 0.0097
Mycobacterium ulcerans NADH dehydrogenase 0.0015 0.0039 0.0096
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0015 0.0039 0.0039
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0066
Mycobacterium leprae conserved hypothetical protein 0.001 0.0016 0.0036
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0153 0.0747 0.1962
Loa Loa (eye worm) hypothetical protein 0.0036 0.0147 0.0385
Schistosoma mansoni hypothetical protein 0.0015 0.0039 0.0039
Mycobacterium ulcerans hypothetical protein 0.001 0.0016 0.0036
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0753 0.3809 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0025 0.0025
Onchocerca volvulus 0.0174 0.0855 0.2948
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0075 0.0197
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.003 0.012 0.0478
Trypanosoma cruzi trypanothione reductase, putative 0.0055 0.0244 0.0625
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0017 0.005 0.0127
Echinococcus multilocularis pyruvate kinase 0.0028 0.0108 0.0108
Echinococcus granulosus 7TM GPCR rhodopsin 0.0012 0.0025 0.0025
Toxoplasma gondii LsmAD domain-containing protein 0.0018 0.0055 0.013
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0014 0.0037 0.0129
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0015 0.0039 0.0137
Echinococcus granulosus sterol O acyltransferase 1 0.0083 0.039 0.039
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0066
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0122 0.0589 0.1554
Entamoeba histolytica heat shock transcription factor, putative 0.0057 0.0254 0.1041
Leishmania major 4-coumarate:coa ligase-like protein 0.0018 0.0057 0.0135
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0066
Schistosoma mansoni glutamate synthase 0.0015 0.0039 0.0039
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0015 0.0039 0.0137
Mycobacterium ulcerans hypothetical protein 0.0015 0.0039 0.0096
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0015 0.0039 0.0086
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.003 0.012 0.0299
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1276 0.6482 0.6482
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0015 0.0039 0.0096
Loa Loa (eye worm) hypothetical protein 0.0015 0.004 0.0105
Echinococcus granulosus g-protein coupled receptor 0.0012 0.0025 0.0025
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0015 0.0039 0.0137
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0035 0.0145 0.0145
Echinococcus multilocularis thioredoxin glutathione reductase 0.0159 0.0778 0.0778
Brugia malayi hypothetical protein 0.0011 0.0023 0.0061
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0052 0.023 0.0942
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0008 0.0006 0.0006
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0025 0.0025
Trypanosoma brucei AMP-activated protein kinase, gamma regulatory subunit 0.001 0.0016 0.0026
Trypanosoma brucei DNA polymerase kappa, putative 0.0011 0.0019 0.0033
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0015 0.0039 0.0039
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0075 0.0197
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0097 0.046 0.0774
Schistosoma mansoni disulfide oxidoreductase 0.0015 0.0039 0.0039
Brugia malayi Telomerase reverse transcriptase 0.0418 0.2099 0.551
Brugia malayi Pre-SET motif family protein 0.0022 0.0077 0.0202
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0075 0.0197
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0042 0.018 0.0466
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0008 0.0006 0.0006
Brugia malayi Calcitonin receptor-like protein seb-1 0.0176 0.0864 0.227
Leishmania major importin beta-1 subunit, putative 0.0017 0.0051 0.0119
Leishmania major telomerase reverse transcriptase, putative 0.0157 0.0767 0.2
Trichomonas vaginalis glucosylceramidase, putative 0.0121 0.0585 0.2434
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0075 0.0197
Loa Loa (eye worm) hypothetical protein 0.001 0.0014 0.0037
Plasmodium falciparum ferrodoxin reductase-like protein 0.0015 0.0039 0.0087
Brugia malayi nuclear receptor NHR-88 0.0022 0.0075 0.0197
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0116 0.0558 0.0558
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0012 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0021 0.0072 0.0188
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0021 0.0069 0.0069
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0015 0.0043 0.0098
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0015 0.0039 0.0086
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0014 0.0037 0.0081
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0075 0.0197
Brugia malayi steroid hormone receptor 0.0022 0.0075 0.0197
Schistosoma mansoni aldehyde dehydrogenase 0.0044 0.019 0.019
Schistosoma mansoni transcription factor LCR-F1 0.0021 0.0069 0.0069
Entamoeba histolytica hypothetical protein 0.0021 0.0069 0.0267
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0041 0.0172 0.0437
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0862 0.3598
Toxoplasma gondii pyruvate kinase PyK1 0.0036 0.0147 0.037
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0021 0.0074 0.0125
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0012 0.0025 0.0025
Schistosoma mansoni terminal deoxycytidyl transferase 0.0015 0.0043 0.0043
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0007 0.0002 0.0004
Trichomonas vaginalis CMGC family protein kinase 0.0041 0.0172 0.0699
Loa Loa (eye worm) HMG box family protein 0.0029 0.0112 0.0295
Brugia malayi exodeoxyribonuclease III family protein 0.0014 0.0037 0.0097
Echinococcus multilocularis isocitrate dehydrogenase 0.0023 0.0084 0.0084
Brugia malayi ubiquitin conjugating enzyme protein 13 0.003 0.012 0.0315
Schistosoma mansoni ran 0.0015 0.0043 0.0043
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0008 0.0005 0.0005
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0022 0.0077 0.0077
Trypanosoma cruzi GMP reductase 0.0753 0.3809 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0017 0.0017
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0082 0.0384 0.1008
Entamoeba histolytica acyl-CoA synthetase, putative 0.0018 0.0057 0.0216
Entamoeba histolytica hypothetical protein 0.0021 0.0069 0.0267
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.001 0.0017 0.0017
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0012 0.0025 0.0025
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.002 0.0068 0.0114
Echinococcus granulosus o acyltransferase membrane bound domain 0.0008 0.0006 0.0006
Onchocerca volvulus 0.0022 0.0077 0.0265
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0075 0.0197
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0023 0.0084 0.0084
Brugia malayi putative neuropeptide receptor 0.0012 0.0025 0.0066
Schistosoma mansoni sulfide quinone reductase 0.0015 0.0039 0.0039
Onchocerca volvulus 0.001 0.0014 0.0049
Loa Loa (eye worm) hypothetical protein 0.004 0.0167 0.0439
Plasmodium vivax acyl-CoA synthetase, putative 0.0014 0.0034 0.0074
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0015 0.0039 0.0065
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0015 0.0039 0.0039
Onchocerca volvulus Heat shock factor protein 2 homolog 0.0057 0.0254 0.0874
Onchocerca volvulus Glucosylceramidase homolog 0.0115 0.0553 0.1907
Echinococcus granulosus biogenic amine 5HT receptor 0.0012 0.0025 0.0025
Schistosoma mansoni pangolin 0.0029 0.0112 0.0112
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0075 0.0075
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0075 0.0075
Brugia malayi ORL1-like opioid receptor 0.0012 0.0025 0.0066
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0015 0.0043 0.0097
Trypanosoma cruzi AMP-activated protein kinase, gamma regulatory subunit 0.001 0.0016 0.0026
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.002 0.0068 0.0172
Loa Loa (eye worm) hypothetical protein 0.0022 0.0075 0.0197
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0008 0.0006 0.0011
Schistosoma mansoni chloride channel protein 0.001 0.0016 0.0016
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0014 0.0037 0.0082
Echinococcus multilocularis orexin receptor type 2 0.0012 0.0025 0.0025
Giardia lamblia Glutamate synthase 0.0015 0.0039 0.0095
Brugia malayi latrophilin 2 splice variant baaae 0.012 0.058 0.1522
Loa Loa (eye worm) hypothetical protein 0.0014 0.0034 0.0089
Mycobacterium tuberculosis Hypoxic response protein 1 Hrp1 0.001 0.0016 0.0027
Trypanosoma cruzi DNA polymerase kappa, putative 0.0015 0.0043 0.0097
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0015 0.0039 0.0137
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0012 0.0025 0.0025
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0014 0.0037 0.0037
Onchocerca volvulus 0.0015 0.0039 0.0133
Onchocerca volvulus 0.001 0.0017 0.006
Mycobacterium ulcerans acyl-CoA synthetase 0.0018 0.0057 0.0145
Brugia malayi RE15519p 0.0012 0.0025 0.0066
Toxoplasma gondii aldehyde dehydrogenase 0.0044 0.019 0.0484
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0055 0.0244 0.0625
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0055 0.0244 0.0625
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0044
Schistosoma mansoni neuropeptide f receptor 76f 0.0012 0.0025 0.0025
Echinococcus granulosus neuropeptide receptor 0.0012 0.0025 0.0025
Loa Loa (eye worm) G-protein coupled receptor 0.0012 0.0025 0.0066
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0023 0.0084 0.0207
Schistosoma mansoni pyruvate kinase 0.0036 0.0147 0.0147
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0017 0.0051 0.0191
Schistosoma mansoni neuropeptide receptor 0.0012 0.0025 0.0025
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0075 0.0197
Mycobacterium tuberculosis Conserved hypothetical protein 0.0015 0.0043 0.0073
Loa Loa (eye worm) pyruvate kinase 0.0008 0.0003 0.0008
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0116 0.0558 0.0558
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0017 0.0017
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0122 0.0589 0.0589
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0055 0.0244 0.0625
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0082 0.0384 0.0384
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.003 0.012 0.0303
Schistosoma mansoni opsin-like receptor 0.0012 0.0025 0.0025
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0147 0.0591
Echinococcus granulosus Protein patched homolog 1 0.0032 0.013 0.013
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0075 0.0197
Brugia malayi Matrixin family protein 0.001 0.0014 0.0037
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0015 0.0039 0.0096
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0023 0.0084 0.0207
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0023 0.0023
Echinococcus granulosus nuclear receptor nhr 48 0.001 0.0017 0.0017
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0039 0.0086
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0023 0.0084 0.0204
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0137 0.0665 0.1119
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.001 0.0016 0.0027
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0122 0.0589 0.1511
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0066
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0008 0.0006 0.0006
Brugia malayi C1-like domain containing protein 0.0015 0.004 0.0105
Brugia malayi glutathione reductase 0.0158 0.077 0.2021
Schistosoma mansoni importin beta-1 0.0021 0.0072 0.0072
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0474 0.2384 1
Giardia lamblia Telomerase catalytic subunit 0.0157 0.0767 0.3169
Echinococcus multilocularis GPCR, family 2 0.0056 0.0249 0.0249
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0195 0.0961 0.2523
Echinococcus granulosus pangolin 0.0029 0.0112 0.0112
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0025 0.0025
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0043 0.0097
Trichomonas vaginalis CMGC family protein kinase 0.0041 0.0172 0.0699
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0015 0.0039 0.0137
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.006
Schistosoma mansoni protein kinase subunit gamma 0.001 0.0016 0.0016
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0015 0.0039 0.0137
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0015 0.0043 0.0043
Treponema pallidum hemolysin (tlyC) 0.001 0.0016 0.0042
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0147 0.037
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0041 0.0172 0.0437
Echinococcus multilocularis protein patched 0.0032 0.013 0.013
Loa Loa (eye worm) nuclear hormone receptor 0.001 0.0017 0.0044
Brugia malayi Tachykinin-like peptides receptor 99D 0.0012 0.0025 0.0066
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0014 0.0037 0.0081
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0015 0.0039 0.0086
Loa Loa (eye worm) hypothetical protein 0.0014 0.0034 0.0089
Echinococcus granulosus 5' AMP activated protein kinase subunit gamma 0.001 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0018 0.0057 0.0151
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0021 0.0074 0.0189
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0041 0.0172 0.0437
Schistosoma mansoni microtubule-associated protein tau 0.1966 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0025 0.0025
Echinococcus multilocularis expressed conserved protein 0.0071 0.0327 0.0327
Onchocerca volvulus 0.0014 0.0035 0.012
Brugia malayi hypothetical protein 0.0012 0.0025 0.0066
Echinococcus multilocularis Smad4 0.0008 0.0006 0.0006
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0055 0.0244 0.0625
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0015 0.0039 0.0086
Brugia malayi Probable ClpP-like protease 0.0122 0.0589 0.1546
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0044
Schistosoma mansoni nuclear receptor 0.001 0.0017 0.0017
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0056 0.0249 0.0249
Schistosoma mansoni hypothetical protein 0.0034 0.0139 0.0139
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0075 0.0075
Trypanosoma brucei hypothetical protein, conserved 0.0015 0.0039 0.0086
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.002 0.0068 0.0172
Mycobacterium ulcerans acyl-CoA synthetase 0.0018 0.0057 0.0145
Onchocerca volvulus 0.0012 0.0025 0.0086
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0025 0.0025
Mycobacterium ulcerans hypothetical protein 0.001 0.0016 0.0036
Schistosoma mansoni peptidase Clp (S14 family) 0.0122 0.0589 0.0589
Loa Loa (eye worm) hypothetical protein 0.007 0.0323 0.0847
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0012 0.0025 0.0066
Brugia malayi hypothetical protein 0.0012 0.0025 0.0066
Trichomonas vaginalis glutamate synthase, putative 0.0015 0.0039 0.0137
Schistosoma mansoni smad1 5 8 and 0.0008 0.0006 0.0006
Mycobacterium ulcerans hydrolase 0.0012 0.0025 0.006
Trypanosoma cruzi chloride channel protein, putative 0.001 0.0016 0.0026
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0753 0.3809 0.3809
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0231 0.1146 0.1929
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0052 0.023 0.0942
Loa Loa (eye worm) hypothetical protein 0.001 0.0014 0.0037
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.004 0.017 0.0445
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0012 0.0025 0.0025
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0055 0.0244 0.0244
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0055 0.0244 0.06
Loa Loa (eye worm) hypothetical protein 0.0039 0.0166 0.0435
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0075 0.0075
Schistosoma mansoni glutamate synthase 0.0015 0.0039 0.0039
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0021 0.0074 0.0125
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0034 0.0139 0.0139
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.001 0.0016 0.0027
Entamoeba histolytica thioredoxin reductase, putative 0.0015 0.0039 0.0137
Mycobacterium ulcerans polyketide synthase Pks9 0.0013 0.0033 0.008
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0474 0.2384 1
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0015 0.0039 0.0065
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0862 0.3598
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0231 0.1142 0.1142
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0263 0.1307 0.3428
Loa Loa (eye worm) G-protein coupled receptor 0.0012 0.0025 0.0066
Echinococcus granulosus tm gpcr rhodopsin 0.0012 0.0025 0.0025
Brugia malayi tailless protein 0.001 0.0017 0.0044
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0015 0.0039 0.0086
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0055 0.0244 0.0625
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0015 0.0039 0.0039
Brugia malayi hypoxia-induced factor 1 0.0065 0.0295 0.0774
Schistosoma mansoni neuropeptide receptor 0.0012 0.0025 0.0025
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0006 0.0015
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0116 0.0558 0.1466
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0862 0.3598
Mycobacterium ulcerans glutamate synthase subunit beta 0.0015 0.0039 0.0096
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0012 0.0025 0.0025
Plasmodium falciparum glutathione reductase 0.0158 0.077 0.2036
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0575 0.2901 1
Leishmania major guanosine monophosphate reductase 0.0753 0.3809 1
Brugia malayi ecdysteroid receptor 0.0022 0.0075 0.0197
Plasmodium vivax telomerase reverse transcriptase, putative 0.0157 0.0767 0.2027
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0043 0.0097
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0137 0.0665 0.1119
Schistosoma mansoni hypothetical protein 0.0031 0.0124 0.0124
Toxoplasma gondii subtilisin SUB1 0.0073 0.0338 0.0874
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0015 0.0039 0.0086
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0055 0.0244 0.0625
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0012 0.0025 0.0025
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0015 0.0043 0.0156
Onchocerca volvulus 0.0018 0.0057 0.0198
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0041 0.0172 0.0437
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.001 0.0016 0.0016
Treponema pallidum exodeoxyribonuclease (exoA) 0.0014 0.0037 0.0129
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0025 0.0025
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.0569 0.1494
Mycobacterium ulcerans polyketide synthase 0.002 0.0068 0.0172
Echinococcus granulosus sterol regulatory element binding protein 0.0032 0.013 0.013
Echinococcus multilocularis neuropeptide receptor A26 0.1006 0.51 0.51
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0018 0.0057 0.0145
Brugia malayi RNA, U transporter 1 0.006 0.0269 0.0707
Onchocerca volvulus 0.0012 0.0025 0.0086
Schistosoma mansoni hypothetical protein 0.0056 0.0249 0.0249
Giardia lamblia Kinase, CMGC MAPK 0.0041 0.0172 0.0659
Echinococcus multilocularis neuropeptide Y receptor 0.0012 0.0025 0.0025
Brugia malayi Protein kinase domain containing protein 0.0245 0.1216 0.3192
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0022 0.0077 0.0186
Leishmania major GTP-binding protein, putative 0.0015 0.0043 0.0098
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0066
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0012 0.0025 0.0025
Brugia malayi HMG box family protein 0.0029 0.0112 0.0295
Plasmodium falciparum importin beta, putative 0.0021 0.0072 0.0175
Brugia malayi hypothetical protein 0.0018 0.0055 0.0146
Echinococcus multilocularis sterol regulatory element binding protein 0.0032 0.013 0.013
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0075 0.0075
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0743 0.3757 1
Schistosoma mansoni pyruvate kinase 0.0018 0.0058 0.0058
Brugia malayi Muscleblind-like protein 0.0223 0.1104 0.29
Onchocerca volvulus Matrilysin homolog 0.001 0.0014 0.0049
Echinococcus multilocularis protein dispatched 1 0.0037 0.0153 0.0153
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0052 0.023 0.0589
Mycobacterium ulcerans Type I modular polyketide synthase 0.002 0.0068 0.0172
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0055 0.0244 0.0625
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0023 0.0084 0.0204
Brugia malayi hypothetical protein 0.0012 0.0025 0.0066
Loa Loa (eye worm) hypothetical protein 0.0022 0.0075 0.0197
Loa Loa (eye worm) neuropeptide F receptor 0.0012 0.0025 0.0066
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0008 0.0006 0.0006
Trichomonas vaginalis glucosylceramidase, putative 0.0115 0.0553 0.2301
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0012 0.0025 0.0066
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0147 0.0591
Echinococcus multilocularis Niemann Pick C1 protein 0.0108 0.0515 0.0515
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0056 0.0249 0.0654
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0015 0.0039 0.0039
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0012 0.0025 0.0025
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0075 0.0075
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0052 0.023 0.0589
Echinococcus granulosus pyruvate kinase 0.0036 0.0147 0.0147
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0012 0.0025 0.0025
Schistosoma mansoni nuclear receptor nhr-48 0.001 0.0017 0.0017
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0014 0.0034 0.0138
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0012 0.0025 0.0025
Schistosoma mansoni nuclear hormone receptor 0.001 0.0017 0.0017
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0052 0.023 0.0589
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0006 0.0006
Toxoplasma gondii thioredoxin reductase 0.0158 0.077 0.2008
Brugia malayi hypothetical protein 0.0012 0.0025 0.0066
Brugia malayi nuclear hormone receptor 0.0022 0.0075 0.0197
Loa Loa (eye worm) nuclear receptor nhr-7B 0.001 0.0017 0.0044
Brugia malayi nuclear receptor RXR 0.001 0.0017 0.0044
Trichomonas vaginalis glucosylceramidase, putative 0.0121 0.0585 0.2434
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0023 0.006
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0044
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0075 0.0075
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0474 0.2384 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0015 0.0039 0.0101
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0023 0.0084 0.0084
Trichomonas vaginalis ap endonuclease, putative 0.0014 0.0037 0.0129
Trypanosoma brucei DNA polymerase IV, putative 0.0015 0.0043 0.0097
Brugia malayi CLC chloride channel protein 0.001 0.0016 0.0042
Schistosoma mansoni hypothetical protein 0.0056 0.0249 0.0249
Loa Loa (eye worm) hypothetical protein 0.0075 0.035 0.0919
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0157 0.0767 0.2
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0753 0.3809 1
Echinococcus granulosus dna polymerase eta 0.0015 0.0043 0.0043
Echinococcus multilocularis T cell transcription factor 4 long C terminal 0.0029 0.0112 0.0112
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0753 0.3809 0.3809
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0044
Brugia malayi putative neuropeptide receptor NPR1 0.0012 0.0025 0.0066
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0015 0.0039 0.0096
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0044 0.019 0.019
Echinococcus multilocularis thyroid hormone receptor alpha 0.0125 0.0605 0.0605
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0055 0.0244 0.0625
Brugia malayi Matrixin family protein 0.001 0.0014 0.0037
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0012 0.0025 0.0025
Brugia malayi Armadillo/beta-catenin-like repeat family protein 0.0043 0.0186 0.0487
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0012 0.0025 0.0025
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0008 0.0006 0.0006
Echinococcus multilocularis neuropeptides capa receptor 0.0012 0.0025 0.0025
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0023 0.0084 0.0204
Schistosoma mansoni zinc finger protein 0.001 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0044
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0017 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0075 0.0197
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0055 0.0244 0.0625
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0015 0.0039 0.0039
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.003 0.012 0.0315
Loa Loa (eye worm) isocitrate dehydrogenase 0.0023 0.0084 0.022
Giardia lamblia Fructose-bisphosphate aldolase 0.0474 0.2384 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.0075 0.0259
Echinococcus granulosus Smad4 0.0008 0.0006 0.0006
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0055 0.0244 0.064
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0075 0.0197
Loa Loa (eye worm) hypothetical protein 0.012 0.058 0.1522
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0015 0.0039 0.0039
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0753 0.3809 1
Leishmania major DNA polymerase kappa, putative 0.0015 0.0043 0.0097
Toxoplasma gondii isocitrate dehydrogenase 0.0023 0.0084 0.0204
Echinococcus granulosus g protein coupled receptor 0.0012 0.0025 0.0025
Schistosoma mansoni hypothetical protein 0.0056 0.0249 0.0249
Echinococcus granulosus neuropeptides capa receptor 0.0012 0.0025 0.0025
Schistosoma mansoni patched 1 0.0032 0.013 0.013
Loa Loa (eye worm) chloride channel 3 0.001 0.0016 0.0042
Onchocerca volvulus 0.0008 0.0006 0.0021
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0013 0.0033 0.008
Schistosoma mansoni hypothetical protein 0.0012 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0015 0.0039 0.0101
Brugia malayi hypothetical protein 0.0012 0.0025 0.0066
Brugia malayi MH2 domain containing protein 0.0118 0.0569 0.1494
Brugia malayi CBS domain containing protein 0.001 0.0016 0.0042
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0015 0.0043 0.0043
Mycobacterium ulcerans DNA polymerase IV 0.0015 0.0043 0.0107
Echinococcus multilocularis neuropeptide receptor 0.0012 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0008 0.0006 0.0016
Loa Loa (eye worm) MBOAT family protein 0.0008 0.0006 0.0016
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0328 0.164 0.4306
Plasmodium vivax ataxin-2 like protein, putative 0.0018 0.0055 0.0132
Loa Loa (eye worm) hypothetical protein 0.0015 0.0043 0.0113
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0008 0.0006 0.0006
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0015 0.0039 0.0101
Plasmodium falciparum pyruvate kinase 2 0.0018 0.0058 0.0138
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0007 0.0002 0.0004
Onchocerca volvulus 0.0012 0.0025 0.0086
Brugia malayi Dopamine receptor protein 2 0.0012 0.0025 0.0066
Brugia malayi isocitrate dehydrogenase 0.0023 0.0084 0.022
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0075 0.0197
Leishmania major hypothetical protein, conserved 0.0018 0.0055 0.013
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.001 0.0017 0.0058
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0055 0.0244 0.041
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0231 0.1142 0.1142
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0015 0.0039 0.0086
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0014 0.0034 0.0057
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0743 0.3757 0.9865
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0015 0.0039 0.0137
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.019 0.0936 0.0936
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0066
Echinococcus granulosus smad 0.0008 0.0006 0.0006
Toxoplasma gondii pyruvate kinase PyKII 0.0018 0.0058 0.0137
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0015 0.004 0.0105
Brugia malayi CHE-14 protein 0.0032 0.013 0.0341
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0024 0.0088 0.0231
Brugia malayi nuclear hormone receptor family member odr-7 0.001 0.0017 0.0044
Entamoeba histolytica deoxycytidyl transferase, putative 0.0015 0.0043 0.0156
Brugia malayi pyruvate kinase 0.0008 0.0003 0.0008
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0075 0.0075
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0055 0.0244 0.0625
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0012 0.0025 0.0025
Brugia malayi Serotonin receptor 0.0012 0.0025 0.0066
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0041 0.0172 0.0437
Echinococcus granulosus histone lysine methyltransferase setb 0.0022 0.0077 0.0077
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0176 0.0862 0.2262
Loa Loa (eye worm) hypothetical protein 0.0034 0.0139 0.0364
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0122 0.0589 0.1554
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0474 0.2384 1
Toxoplasma gondii hypothetical protein 0.0042 0.018 0.0457
Plasmodium falciparum thioredoxin reductase 0.0158 0.077 0.2036
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0147 0.0385
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0082 0.0384 0.0384
Schistosoma mansoni hypothetical protein 0.0031 0.0124 0.0124
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.003 0.012 0.0303
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0231 0.1146 0.3006
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0082 0.0384 0.0384
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0008 0.0006 0.0016
Brugia malayi sulfakinin receptor protein 0.0012 0.0025 0.0066
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.001 0.0017 0.0044
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0082 0.0384 0.0384
Echinococcus granulosus somatostatin receptor 0.0012 0.0025 0.0025
Schistosoma mansoni smad1 5 8 and 0.0008 0.0006 0.0006
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0075 0.0075
Echinococcus granulosus 7tm_1 domain containing protein 0.0012 0.0025 0.0025
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0015 0.0039 0.0096
Toxoplasma gondii type I fatty acid synthase, putative 0.0022 0.0078 0.0189
Schistosoma mansoni nuclear receptor 0.001 0.0017 0.0017
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0025 0.0025
Loa Loa (eye worm) thioredoxin reductase 0.0158 0.077 0.2021
Entamoeba histolytica Ran family GTPase 0.0015 0.0043 0.0157
Toxoplasma gondii selenide, water dikinase 0.0015 0.0039 0.0086
Mycobacterium tuberculosis Probable conserved transmembrane alanine and leucine rich protein 0.001 0.0016 0.0027
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0012 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0066
Schistosoma mansoni growth hormone secretagogue receptor 0.0012 0.0025 0.0025
Brugia malayi MBOAT family protein 0.0008 0.0006 0.0016
Echinococcus multilocularis 5' AMP activated protein kinase subunit gamma 0.001 0.0016 0.0016
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0008 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.0104 0.0494 0.0494
Echinococcus granulosus hypothetical protein 0.0012 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0066
Mycobacterium leprae Probable pyruvate kinase PykA 0.0036 0.0147 0.0379
Schistosoma mansoni biogenic amine receptor 0.0012 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0223 0.1104 0.29
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0015 0.0039 0.0086
Leishmania major inosine-5-monophosphate dehydrogenase 0.0753 0.3809 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0066
Leishmania major hypothetical protein, conserved 0.0015 0.0039 0.0086
Echinococcus granulosus pyruvate kinase 0.0036 0.0147 0.0147
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0034 0.0139 0.0139
Echinococcus multilocularis dna polymerase kappa 0.0015 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0066
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0008 0.0006 0.0006
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0015 0.0039 0.0087
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0052 0.023 0.0942
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0035 0.0145 0.0145
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0034 0.0139 0.0139
Brugia malayi hypothetical protein 0.001 0.0017 0.0044
Onchocerca volvulus 0.0012 0.0025 0.0086
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0066
Trichomonas vaginalis importin beta-1, putative 0.0017 0.0051 0.0191
Trypanosoma cruzi NADH dehydrogenase, putative 0.0015 0.0039 0.0086
Mycobacterium ulcerans pyruvate kinase 0.0036 0.0147 0.0379
Mycobacterium ulcerans polyketide synthase 0.0021 0.0074 0.0189
Schistosoma mansoni Smad4 0.0008 0.0006 0.0006
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0015 0.0039 0.0137
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0012 0.0025 0.0066
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.008 0.0374 0.0976
Onchocerca volvulus 0.0013 0.003 0.0103
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0032 0.013 0.0341
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0075 0.0075
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0015 0.0039 0.0059
Echinococcus multilocularis H(+):Cl() exchange transporter 4 0.001 0.0016 0.0016
Echinococcus multilocularis dna polymerase eta 0.0015 0.0043 0.0043
Echinococcus granulosus geminin 0.0212 0.1047 0.1047
Schistosoma mansoni hypothetical protein 0.0008 0.0006 0.0006
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0104 0.0494 0.0494
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0012 0.0025 0.0025
Mycobacterium ulcerans thioesterase TesA 0.0017 0.005 0.0127
Loa Loa (eye worm) MBOAT family protein 0.0008 0.0006 0.0016
Toxoplasma gondii type I fatty acid synthase, putative 0.0014 0.0038 0.0084
Loa Loa (eye worm) programmed cell death 8 0.0015 0.0039 0.0101
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0015 0.0039 0.0137
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0015 0.0043 0.0043
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0147 0.0505
Brugia malayi pyruvate kinase, muscle isozyme 0.0008 0.0003 0.0008
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0015 0.0039 0.0039
Entamoeba histolytica hypothetical protein 0.0021 0.0069 0.0267
Echinococcus multilocularis snurportin 1 0.0224 0.1108 0.1108
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0044
Schistosoma mansoni hypothetical protein 0.0212 0.1047 0.1047
Onchocerca volvulus 0.0012 0.0025 0.0086
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0015 0.0039 0.0137
Toxoplasma gondii exonuclease III APE 0.0014 0.0037 0.0081
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.001 0.0017 0.0017
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0022 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0066
Brugia malayi MBOAT family protein 0.0008 0.0006 0.0016
Echinococcus multilocularis pyruvate kinase 0.0036 0.0147 0.0147
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0075 0.0197
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0066
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0044
Schistosoma mansoni hypothetical protein 0.0031 0.0124 0.0124
Onchocerca volvulus 0.001 0.0016 0.0055
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0122 0.0589 0.0589
Loa Loa (eye worm) hypothetical protein 0.0014 0.0038 0.0099
Schistosoma mansoni hypothetical protein 0.0031 0.0124 0.0124
Mycobacterium ulcerans Type I modular polyketide synthase 0.002 0.0068 0.0172
Echinococcus granulosus tachykinin peptides receptor 99D 0.0012 0.0025 0.0025
Brugia malayi hypothetical protein 0.0012 0.0025 0.0066
Brugia malayi orphan nuclear receptor NR2E1 0.001 0.0017 0.0044
Loa Loa (eye worm) hypothetical protein 0.001 0.0016 0.0042
Onchocerca volvulus Putative GMP reductase 0.0328 0.164 0.5655
Echinococcus multilocularis muscleblind protein 0.0223 0.1104 0.1104
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0025 0.0025
Echinococcus multilocularis peptidase Clp (S14 family) 0.008 0.0374 0.0374
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0044
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0044 0.019 0.019
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0055 0.0244 0.0633
Trypanosoma cruzi chloride channel protein, putative 0.001 0.0016 0.0026
Trypanosoma cruzi importin beta-1 subunit, putative 0.0017 0.0051 0.0119
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0008 0.0006 0.0006
Brugia malayi GnHR receptor homolog 0.0012 0.0025 0.0066
Loa Loa (eye worm) matrixin family protein 0.0022 0.0075 0.0196
Schistosoma mansoni biogenic amine (5HT) receptor 0.0012 0.0025 0.0025
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0012 0.0025 0.0066
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0047 0.0202 0.034
Brugia malayi hypothetical protein 0.0103 0.049 0.1285
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0743 0.3757 1
Onchocerca volvulus 0.0015 0.004 0.0138
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0066
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0023 0.0084 0.0204
Schistosoma mansoni histamine h1 receptor 0.0012 0.0025 0.0025
Schistosoma mansoni sulfide quinone reductase 0.0015 0.0039 0.0039
Plasmodium vivax subtilisin-like protease 1 0.0073 0.0338 0.0886
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0147 0.037
Echinococcus multilocularis fmrfamide receptor 0.0012 0.0025 0.0025
Schistosoma mansoni alpha-1 adrenergic receptor 0.0012 0.0025 0.0025
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0015 0.0043 0.0113
Loa Loa (eye worm) loechrig isoform VII 0.001 0.0016 0.0042
Brugia malayi Latrophilin receptor protein 2 0.0056 0.0249 0.0654
Loa Loa (eye worm) hypothetical protein 0.0176 0.0864 0.227
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0007 0.0002 0.0004
Schistosoma mansoni amine GPCR 0.0012 0.0025 0.0025
Trypanosoma cruzi DNA polymerase kappa, putative 0.0015 0.0043 0.0097
Schistosoma mansoni amine GPCR 0.0012 0.0025 0.0025
Echinococcus granulosus dro:myosuppressin receptor 0.0012 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0066
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0025 0.0025
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0055 0.0244 0.0244
Brugia malayi Niemann-Pick C1 protein precursor 0.0075 0.035 0.0919
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0176 0.0864 0.227
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0025 0.0025
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0082 0.0384 0.1008
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0066
Brugia malayi GMP reductase 0.0328 0.164 0.4306
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.002 0.0068 0.0177
Loa Loa (eye worm) Smad1 0.0008 0.0006 0.0015
Onchocerca volvulus 0.0012 0.0025 0.0086
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0008 0.0006 0.0006
Echinococcus multilocularis somatostatin receptor 0.0012 0.0025 0.0025
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0025 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0075 0.0197
Schistosoma mansoni opsin-like receptor 0.0012 0.0025 0.0025
Brugia malayi MAP kinase sur-1 0.0041 0.0172 0.0452
Echinococcus granulosus AMP activated protein kinase gamma regulatory 0.001 0.0016 0.0016
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0013 0.0032 0.0084
Onchocerca volvulus 0.0012 0.0025 0.0086
Echinococcus granulosus neuropeptide Y receptor 0.0012 0.0025 0.0025
Mycobacterium leprae PROBABLE HYDROLASE 0.0012 0.0025 0.006
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0012 0.0025 0.0025
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0055 0.0244 0.0244
Loa Loa (eye worm) hypothetical protein 0.0103 0.049 0.1285
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0015 0.0039 0.0086
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0025 0.0025
Onchocerca volvulus 0.0012 0.0025 0.0086
Schistosoma mansoni hypothetical protein 0.0034 0.0139 0.0139
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0082 0.0384 0.0384
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0753 0.3809 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0044
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0055 0.0244 0.0633
Loa Loa (eye worm) hypothetical protein 0.0057 0.0254 0.0666
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0066
Loa Loa (eye worm) fatty acid synthase 0.002 0.0066 0.0174
Schistosoma mansoni biogenic amine receptor 0.0012 0.0025 0.0025
Echinococcus granulosus Niemann Pick C1 protein 0.0108 0.0515 0.0515
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0018 0.0057 0.0145
Schistosoma mansoni protein kinase C mu 0.0015 0.004 0.004
Brugia malayi AKH receptor 0.0012 0.0025 0.0066
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0066
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0012 0.0025 0.0025
Trypanosoma cruzi chloride channel protein, putative 0.001 0.0016 0.0026
Trichomonas vaginalis mercuric reductase, putative 0.0055 0.0244 0.0999
Schistosoma mansoni thyroid hormone receptor 0.0125 0.0605 0.0605
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0075 0.0197
Echinococcus multilocularis tumor protein p63 0.0269 0.134 0.134
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0017 0.0017
Onchocerca volvulus 0.0022 0.0075 0.0259
Brugia malayi MH2 domain containing protein 0.0008 0.0006 0.0015
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.003 0.012 0.0299
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0097 0.046 0.0774
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.008 0.0374 0.0629
Brugia malayi hypothetical protein 0.0012 0.0025 0.0066
Brugia malayi diacylglycerol acyltransferase 0.0008 0.0006 0.0016
Mycobacterium ulcerans acyl-CoA synthetase 0.0018 0.0057 0.0145
Echinococcus multilocularis inositol monophosphatase 1 0.0052 0.023 0.023
Loa Loa (eye worm) hypothetical protein 0.0011 0.0022 0.0059
Onchocerca volvulus Matrix metalloproteinase homolog 0.0022 0.0075 0.0257
Loa Loa (eye worm) hypothetical protein 0.0018 0.0057 0.0151
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0012 0.0025 0.0025
Brugia malayi MH1 domain containing protein 0.0008 0.0006 0.0015
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0116 0.0558 0.0558
Echinococcus granulosus single minded 2 0.0015 0.0044 0.0044
Trypanosoma cruzi AMP-activated protein kinase, gamma regulatory subunit 0.001 0.0016 0.0026
Loa Loa (eye worm) hypothetical protein 0.0223 0.1104 0.29
Trichomonas vaginalis CMGC family protein kinase 0.0041 0.0172 0.0699
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.0075 0.0259
Brugia malayi hypothetical protein 0.0021 0.0069 0.0182
Echinococcus multilocularis protein pangolin J 0.0029 0.0112 0.0112
Entamoeba histolytica pyruvate kinase, putative 0.0025 0.0092 0.0359
Echinococcus granulosus tm gpcr rhodopsin 0.0012 0.0025 0.0025
Echinococcus granulosus thioredoxin glutathione reductase 0.0159 0.0778 0.0778
Schistosoma mansoni hypothetical protein 0.0012 0.0025 0.0025
Brugia malayi neuropeptide F receptor 0.0012 0.0025 0.0066
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0025 0.0025
Brugia malayi hypothetical protein 0.001 0.0017 0.0044
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0015 0.0039 0.0086
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0066
Echinococcus multilocularis muscleblind protein 1 0.0223 0.1104 0.1104
Loa Loa (eye worm) hypothetical protein 0.0018 0.0055 0.0146
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0066
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0056 0.0249 0.0249
Brugia malayi Nuclear hormone receptor E75 0.001 0.0017 0.0044
Trichomonas vaginalis inositol monophosphatase, putative 0.0052 0.023 0.0942
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0042 0.018 0.0463
Echinococcus granulosus pyruvate kinase 0.0018 0.0058 0.0058
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0012 0.0025 0.0025
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0231 0.1146 0.3006
Onchocerca volvulus 0.0012 0.0025 0.0086
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0015 0.0039 0.0086
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0008 0.0006 0.0006
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.002 0.0064 0.0108
Trypanosoma brucei unspecified product 0.0011 0.0019 0.0033
Brugia malayi Hhat protein 0.0008 0.0006 0.0016
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0022 0.0077 0.0077
Schistosoma mansoni thyroid hormone receptor 0.0125 0.0605 0.0605
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0015 0.0039 0.0065
Brugia malayi ecdysone receptor 0.001 0.0017 0.0044
Schistosoma mansoni hypothetical protein 0.012 0.058 0.058
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.006
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0014 0.0037 0.0081
Brugia malayi hypothetical protein 0.0012 0.0025 0.0066
Echinococcus granulosus Niemann Pick C1 protein 0.0075 0.035 0.035
Echinococcus granulosus H:Cl exchange transporter 7 0.001 0.0016 0.0016
Mycobacterium ulcerans transcriptional regulator 0.001 0.0016 0.0036
Echinococcus multilocularis H(+):Cl() exchange transporter 7 0.001 0.0016 0.0016
Echinococcus multilocularis nuclear receptor nhr 48 0.001 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0014 0.0034 0.0089
Treponema pallidum replicative DNA helicase (dnaB) 0.0263 0.1307 0.5471
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0022 0.0077 0.0077
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0008 0.0006 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.013 0.0521
Schistosoma mansoni coup transcription factor 0.0022 0.0075 0.0075
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.003 0.012 0.0478
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.0908 0.46 0.7741
Trypanosoma brucei Voltage-gated Chloride channel Like 1 0.001 0.0016 0.0026
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0052 0.023 0.0589
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0012 0.0025 0.0025
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0474 0.2384 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0017 0.0017
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0077 0.0356 0.0356
Trypanosoma brucei unspecified product 0.0011 0.0019 0.0033
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0415 0.2082 0.3503
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0862 0.3598
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.0263 0.1307 0.3428
Trichomonas vaginalis glucosylceramidase, putative 0.0115 0.0553 0.2301
Loa Loa (eye worm) chloride channel protein 7 0.001 0.0016 0.0042
Schistosoma mansoni hypothetical protein 0.0212 0.1047 0.1047
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0066

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 24.9 nM Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]-ET-1 as radioligand ChEMBL. 15139756
IC50 (functional) = 24.9 nM Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]-ET-1 as radioligand ChEMBL. 15139756
IC50 (functional) = 241 nM Antagonist activity towards human recombinant Endothelin B receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]-ET-1 as radioligand ChEMBL. 15139756
IC50 (functional) = 241 nM Antagonist activity towards human recombinant Endothelin B receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]-ET-1 as radioligand ChEMBL. 15139756
pA2 (functional) Inhibitory potency at native endothelin A and endothelin B receptors by inhibiting endothelin-1 contractions of rat aortic rings ChEMBL. 15139756
pA2 (functional) 0 Inhibitory potency at native endothelin A and endothelin B receptors by inhibiting endothelin-1 contractions of rat aortic rings ChEMBL. 15139756

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.