Detailed information for compound 1591857

Basic information

Technical information
  • TDR Targets ID: 1591857
  • Name: N-[(4-chlorophenyl)amino]-2-imino-2-piperidin -1-ylethanimidoyl cyanide
  • MW: 289.763 | Formula: C14H16ClN5
  • H donors: 1 H acceptors: 1 LogP: 4.02 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#C/C(=N\Nc1ccc(cc1)Cl)/C(=N)N1CCCCC1
  • InChi: 1S/C14H16ClN5/c15-11-4-6-12(7-5-11)18-19-13(10-16)14(17)20-8-2-1-3-9-20/h4-7,17-18H,1-3,8-9H2/b17-14?,19-13+
  • InChiKey: RXFDLNWXSYKJNN-QFVQXBGYSA-N  


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Synonyms

  • N-[(4-chlorophenyl)amino]-2-imino-2-(1-piperidyl)acetimidoyl cyanide
  • (2E)-2-[(4-chlorophenyl)hydrazono]-3-imino-3-(1-piperidyl)propanenitrile
  • 2-[(4-chlorophenyl)hydrazono]-3-imino-3-(1-piperidyl)propanenitrile
  • 2-[(4-chlorophenyl)hydrazono]-3-imino-3-piperidino-propionitrile
  • (2E)-2-[(4-chlorophenyl)hydrazono]-3-imino-3-piperidino-propionitrile
  • (2E)-2-[(4-chlorophenyl)hydrazinylidene]-3-imino-3-piperidin-1-yl-propanenitrile
  • 2-[(4-chlorophenyl)hydrazinylidene]-3-imino-3-piperidin-1-yl-propanenitrile
  • 2-[(4-Chloro-phenyl)-hydrazono]-3-imino-3-piperidin-1-yl-propionitrile
  • STOCK1S-13093
  • MLS000552608
  • SMR000146123

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens multiple endocrine neoplasia I No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Homo sapiens arachidonate 15-lipoxygenase, type B Starlite/ChEMBL No references
Homo sapiens arachidonate 12-lipoxygenase Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references
Homo sapiens nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) No references
Homo sapiens nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens v-rel avian reticuloendotheliosis viral oncogene homolog A No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma japonicum IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing Get druggable targets OG5_127482 All targets in OG5_127482
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Echinococcus granulosus arachidonate 5 lipoxygenase arachidonate 12-lipoxygenase 663 aa 662 aa 22.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major malate dehydrogenase, putative 0.0525 0.6362 0.6354
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0485 0.0485
Brugia malayi Death domain containing protein 0.0038 0.0326 0.0326
Toxoplasma gondii histone lysine methyltransferase SET1 0.0069 0.0703 0.0703
Echinococcus multilocularis Ankyrin 0.0038 0.0328 0.0328
Chlamydia trachomatis malate dehydrogenase 0.0758 0.9253 1
Wolbachia endosymbiont of Brugia malayi malate dehydrogenase 0.0819 1 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0029 0.0215 0.0215
Echinococcus granulosus RUN 0.0048 0.0443 0.0443
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0208 0.0208
Mycobacterium leprae PROBABLE MALATE DEHYDROGENASE MDH 0.0758 0.9253 1
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.1327 0.1327
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0108 0.0108
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0485 0.0524
Trichomonas vaginalis malate dehydrogenase, putative 0.0758 0.9253 1
Brugia malayi Cytochrome P450 family protein 0.0022 0.0129 0.0129
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0074 0.0771 0.0771
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0103 0.0087
Mycobacterium leprae Conserved hypothetical protein 0.0014 0.0023 0.0025
Brugia malayi PHD-finger family protein 0.0032 0.025 0.025
Onchocerca volvulus 0.0048 0.0443 0.7708
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0208 0.0208
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0129 0.0129
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0208 0.0208
Echinococcus multilocularis protein patched 0.0051 0.0485 0.0485
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0208 0.0224
Loa Loa (eye worm) hypothetical protein 0.0053 0.0516 0.0516
Echinococcus granulosus expressed conserved protein 0.0112 0.1237 0.1237
Schistosoma mansoni hypothetical protein 0.0018 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0038 0.0326 0.0326
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0118 0.0118
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0014 0.0023 0.0025
Schistosoma mansoni ankyrin 23/unc44 0.0038 0.0326 0.0326
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0208 0.0185
Loa Loa (eye worm) hypothetical protein 0.0021 0.0118 0.0118
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0118 0.0127
Trichomonas vaginalis malate dehydrogenase, putative 0.0758 0.9253 1
Leishmania major malate dehydrogenase, putative 0.0819 1 1
Echinococcus granulosus L lactate dehydrogenase 0.0293 0.3491 0.3491
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0208 0.0185
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0485 0.0485
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0014 0.0023 0.0025
Trichomonas vaginalis malate dehydrogenase, putative 0.0758 0.9253 1
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0014 0.0023 0.0025
Echinococcus granulosus cpg binding protein 0.0039 0.0336 0.0336
Onchocerca volvulus 0.0048 0.0443 0.7708
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0029 0.0215 0.0215
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0208 0.0208
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0762 0.0762
Loa Loa (eye worm) hypothetical protein 0.0038 0.0328 0.0328
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0695 0.8464 0.9147
Echinococcus multilocularis zinc finger protein 0.0026 0.017 0.017
Schistosoma mansoni hypothetical protein 0.0049 0.0462 0.0462
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0758 0.9253 1
Leishmania major glycosomal malate dehydrogenase 0.0695 0.8464 0.8461
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0391 0.0391
Toxoplasma gondii lactate dehydrogenase LDH1 0.0819 1 1
Schistosoma mansoni malate dehydrogenase 0.0695 0.8464 0.8464
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.023 0.0249
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0129 0.0139
Brugia malayi Immunoglobulin I-set domain containing protein 0.0038 0.0326 0.0326
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0162 0.0162
Loa Loa (eye worm) hypothetical protein 0.0029 0.0208 0.0208
Loa Loa (eye worm) hypothetical protein 0.003 0.023 0.023
Brugia malayi hypothetical protein 0.0048 0.0443 0.0443
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0014 0.0023 0.0025
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0209 0.2445 0.2445
Schistosoma mansoni lipoxygenase 0.0209 0.2445 0.2445
Echinococcus multilocularis L lactate dehydrogenase 0.0293 0.3491 0.3491
Toxoplasma gondii lactate dehydrogenase LDH2 0.0819 1 1
Entamoeba histolytica malate dehydrogenase, putative 0.0819 1 1
Schistosoma mansoni lipoxygenase 0.0123 0.1382 0.1382
Onchocerca volvulus Netrin receptor homolog 0.0038 0.0326 0.5675
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0253 0.0253
Brugia malayi Bromodomain containing protein 0.0046 0.0426 0.0426
Trypanosoma brucei malate dehydrogenase-related 0.0525 0.6362 0.6875
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0208 0.0224
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0208 0.0224
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0014 0.0023 0.0025
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0758 0.9253 1
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0014 0.0023 0.0025
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0014 0.0023 0.0025
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0038 0.0328 0.0328
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0762 0.0823
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0038 0.0326 0.0326
Echinococcus granulosus netrin receptor unc 5 0.0038 0.0326 0.0326
Entamoeba histolytica malate dehydrogenase,cytoplasmic, putative 0.0758 0.9253 0.9253
Brugia malayi Bromodomain containing protein 0.0093 0.1 0.1
Echinococcus multilocularis lactate dehydrogenase a 0.0819 1 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0485 0.0485
Schistosoma mansoni hypothetical protein 0.0014 0.0022 0.0022
Leishmania major cytochrome p450-like protein 0.0022 0.0129 0.0106
Loa Loa (eye worm) hypothetical protein 0.0021 0.0118 0.0118
Leishmania major mitochondrial malate dehydrogenase 0.0695 0.8464 0.8461
Trichomonas vaginalis malate dehydrogenase, putative 0.0525 0.6362 0.6875
Echinococcus granulosus Ankyrin 0.0038 0.0328 0.0328
Brugia malayi Cytochrome P450 family protein 0.0032 0.0253 0.0253
Trichomonas vaginalis malate dehydrogenase, putative 0.0758 0.9253 1
Echinococcus multilocularis lactate dehydrogenase a 0.0819 1 1
Echinococcus multilocularis lactate dehydrogenase protein 0.0819 1 1
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0014 0.0023 0.0025
Trichomonas vaginalis malate dehydrogenase, putative 0.0256 0.3024 0.3268
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0208 0.0224
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0014 0.0023 0.0025
Schistosoma mansoni netrin receptor unc5 0.0038 0.0326 0.0326
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0208 0.02
Trypanosoma cruzi ISWI complex protein 0.0018 0.0082 0.0088
Echinococcus multilocularis cpg binding protein 0.0039 0.0336 0.0336
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0208 0.0208
Plasmodium vivax malate dehydrogenase, putative 0.0819 1 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0762 0.0823
Toxoplasma gondii malate dehydrogenase MDH 0.0819 1 1
Schistosoma mansoni bromodomain containing protein 0.0078 0.0824 0.0824
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0021 0.0117 0.0117
Brugia malayi Probable malate dehydrogenase, mitochondrial precursor 0.0695 0.8464 0.8464
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0758 0.9253 0.9253
Brugia malayi Protein kinase domain containing protein 0.0038 0.0326 0.0326
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0014 0.0023 0.0025
Plasmodium falciparum malate dehydrogenase 0.0819 1 1
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0485 0.0485
Brugia malayi Cytochrome P450 family protein 0.0022 0.0129 0.0129
Leishmania major cytosolic malate dehydrogenase 0.0758 0.9253 0.9252
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.1327 0.1327
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0485 0.0485
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0762 0.0823
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.1327 0.1327
Schistosoma mansoni hypothetical protein 0.0014 0.0023 0.0023
Schistosoma mansoni loxhd1 0.0048 0.0443 0.0443
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0014 0.0023 0.0025
Echinococcus granulosus malate dehydrogenase 0.0695 0.8464 0.8464
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0209 0.2445 0.2445
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0208 0.0224
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0014 0.0023 0.0025
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.023 0.023
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0208 0.0224
Schistosoma mansoni zinc finger protein 0.0018 0.0082 0.0082
Brugia malayi hypothetical protein 0.0286 0.3393 0.3393
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0108 0.0108
Brugia malayi hypothetical protein 0.002 0.0096 0.0096
Brugia malayi Malate dehydrogenase, cytoplasmic 0.0758 0.9253 0.9253
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0758 0.9253 0.9253
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0208 0.0224
Loa Loa (eye worm) cytochrome P450 0.0014 0.0023 0.0023
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0103 0.0087
Echinococcus granulosus lactate dehydrogenase a 0.0819 1 1
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.023 0.023
Trichomonas vaginalis malate dehydrogenase, putative 0.0758 0.9253 1
Echinococcus granulosus malate dehydrogenase 0.0695 0.8464 0.8464
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0118 0.0127
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0103 0.0087
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.3393 0.3393
Echinococcus multilocularis lipoxygenase domain containing protein 0.0048 0.0443 0.0443
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0765 0.0765
Loa Loa (eye worm) hypothetical protein 0.0286 0.3393 0.3393
Onchocerca volvulus 0.0058 0.0575 1
Leishmania major malate dehydrogenase 0.0695 0.8464 0.8461
Loa Loa (eye worm) hypothetical protein 0.0029 0.0208 0.0208
Echinococcus granulosus lactate dehydrogenase a 0.0819 1 1
Schistosoma mansoni malate dehydrogenase 0.0758 0.9253 0.9253
Trypanosoma brucei cytosolic malate dehydrogenase 0.0758 0.9253 1
Treponema pallidum DNA ligase (lig) 0.0012 0 0.5
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.1959 0.1959
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.023 0.023
Trypanosoma brucei mitochondrial malate dehydrogenase 0.0695 0.8464 0.9147
Schistosoma mansoni hypothetical protein 0.0058 0.0575 0.0575
Brugia malayi CHE-14 protein 0.0051 0.0485 0.0485
Loa Loa (eye worm) hypothetical protein 0.0819 1 1
Echinococcus multilocularis L lactate dehydrogenase B chain 0.0819 1 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0208 0.02
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0014 0.0023 0.0025
Echinococcus multilocularis lactate dehydrogenase a 0.0819 1 1
Mycobacterium ulcerans hypothetical protein 0.0029 0.0208 0.0224
Echinococcus granulosus cytosolic malate dehydrogenase 0.0758 0.9253 0.9253
Loa Loa (eye worm) hypothetical protein 0.0048 0.0443 0.0443
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0103 0.0087
Echinococcus multilocularis malate dehydrogenase 0.0695 0.8464 0.8464
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0762 0.0762
Plasmodium vivax lactate dehydrogenase 0.0819 1 1
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.1327 0.1327
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0014 0.0023 0.0025
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0129 0.0139
Trypanosoma brucei glycosomal malate dehydrogenase 0.0695 0.8464 0.9147
Leishmania major hypothetical protein, conserved 0.003 0.023 0.0207
Trichomonas vaginalis malate dehydrogenase, putative 0.0758 0.9253 1
Schistosoma mansoni cpg binding protein 0.0039 0.0336 0.0336
Loa Loa (eye worm) hypothetical protein 0.0049 0.0462 0.0462
Trypanosoma cruzi malate dehydrogenase, putative 0.0695 0.8464 0.9147
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.023 0.023
Loa Loa (eye worm) hypothetical protein 0.0085 0.0911 0.0911
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0074 0.0771 0.0771
Trypanosoma brucei ISWI complex protein 0.0018 0.0082 0.0088
Schistosoma mansoni malate dehydrogenase 0.0819 1 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.0022 0.0022
Brugia malayi Uncoordinated protein 44 0.0038 0.0326 0.0326
Echinococcus multilocularis RUN 0.0048 0.0443 0.0443
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0118 0.0103
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0014 0.0023 0.0025
Giardia lamblia Malate dehydrogenase 0.0758 0.9253 1
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0014 0.0023 0.0025
Plasmodium falciparum lactate dehydrogenase, putative 0.0525 0.6362 0.6362
Schistosoma mansoni rab6-interacting 0.0048 0.0443 0.0443
Plasmodium falciparum L-lactate dehydrogenase 0.0819 1 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0022 0.0129 0.0139
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.023 0.0249
Trypanosoma cruzi ISWI complex protein 0.0018 0.0082 0.0088
Trichomonas vaginalis malate dehydrogenase, putative 0.0758 0.9253 1
Leishmania major hypothetical protein, conserved 0.0018 0.0082 0.0059
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0695 0.8464 0.9147
Echinococcus granulosus cytosolic malate dehydrogenase 0.0758 0.9253 0.9253
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0118 0.0118
Schistosoma mansoni hypothetical protein 0.0025 0.0162 0.0162
Schistosoma mansoni patched 1 0.0051 0.0485 0.0485
Schistosoma mansoni rab6-interacting 0.0048 0.0443 0.0443
Loa Loa (eye worm) malate dehydrogenase 0.0695 0.8464 0.8464
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0758 0.9253 1
Plasmodium vivax multidomain scavenger receptor, putative 0.0048 0.0443 0.0443
Loa Loa (eye worm) hypothetical protein 0.0021 0.0118 0.0118
Loa Loa (eye worm) malate dehydrogenase 0.0758 0.9253 0.9253
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0117 0.0117
Mycobacterium ulcerans malate dehydrogenase 0.0758 0.9253 1
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0014 0.0023 0.0025
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0758 0.9253 1
Schistosoma mansoni hypothetical protein 0.0049 0.0462 0.0462
Loa Loa (eye worm) hypothetical protein 0.0048 0.0443 0.0443
Echinococcus granulosus methyl CpG binding domain protein 2 0.0021 0.0108 0.0108
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0208 0.0224
Trypanosoma cruzi mitochondrial malate dehydrogenase, putative 0.0695 0.8464 0.9147
Loa Loa (eye worm) hypothetical protein 0.0029 0.0208 0.0208
Brugia malayi CXXC zinc finger family protein 0.0035 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0021 0.0118 0.0118
Echinococcus granulosus Polycystic kidney disease protein 0.0048 0.0443 0.0443
Brugia malayi hypothetical protein 0.003 0.023 0.023
Loa Loa (eye worm) doublecortin family protein 0.0048 0.0443 0.0443
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.3393 0.3393
Loa Loa (eye worm) hypothetical protein 0.0021 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0021 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.0062 0.0627 0.0627
Trichomonas vaginalis malate dehydrogenase, putative 0.0758 0.9253 1
Echinococcus granulosus lactate dehydrogenase protein 0.0819 1 1
Schistosoma mansoni malate dehydrogenase 0.0758 0.9253 0.9253
Plasmodium vivax lactate/malate dehydrogenase, putative 0.0525 0.6362 0.6362
Trypanosoma cruzi malate dehydrogenase, putative 0.0525 0.6362 0.6875
Loa Loa (eye worm) hypothetical protein 0.0119 0.1327 0.1327
Schistosoma mansoni L-lactate dehydrogenase 0.0525 0.6362 0.6362
Entamoeba histolytica malate dehydrogenase, putative 0.0758 0.9253 0.9253
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0208 0.0224
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0762 0.074
Brugia malayi Cytochrome P450 family protein 0.0014 0.0023 0.0023
Echinococcus multilocularis protein dispatched 1 0.0058 0.0574 0.0574
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0758 0.9253 1
Echinococcus granulosus dnaJ subfamily B 0.0494 0.5976 0.5976
Trichomonas vaginalis malate dehydrogenase, putative 0.0489 0.5915 0.6392
Trichomonas vaginalis malate dehydrogenase, putative 0.0758 0.9253 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.0022 0.0022
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0374 0.4483 0.4483
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0208 0.0185
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0014 0.0023 0.0025
Schistosoma mansoni cytochrome P450 0.0014 0.0023 0.0023
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0762 0.0762
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0014 0.0023 0.0025
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0283 0.0283
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0014 0.0023 0.0025
Loa Loa (eye worm) CYP4Cod1 0.0022 0.0129 0.0129
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0762 0.0762
Trichomonas vaginalis malate dehydrogenase, putative 0.0758 0.9253 1
Echinococcus granulosus cytochrome P450 2K1 0.0014 0.0023 0.0023
Echinococcus granulosus nuclear factor of activated T cells 5 0.0374 0.4483 0.4483
Echinococcus granulosus lipoxygenase domain containing protein 0.0048 0.0443 0.0443
Trypanosoma brucei cytochrome P450, putative 0.0022 0.0129 0.0139
Schistosoma mansoni cpg binding protein 0.0039 0.0336 0.0336
Echinococcus granulosus lipoxygenase domain containing protein 0.0048 0.0443 0.0443
Schistosoma mansoni hypothetical protein 0.0038 0.0326 0.0326
Echinococcus multilocularis netrin receptor unc 5 0.0038 0.0326 0.0326
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0014 0.0023 0.0025
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0014 0.0023 0.0025
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0029 0.0215 0.0215
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0208 0.0208
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0021 0.0108 0.0108
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0014 0.0023 0.0025
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0762 0.08
Echinococcus multilocularis 0.0014 0.0023 0.0023
Schistosoma mansoni survival motor neuron protein 0.0058 0.0575 0.0575
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.5976 0.5976
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0391 0.0391
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0129 0.0129
Brugia malayi F/Y-rich N-terminus family protein 0.0013 0.0013 0.0013
Schistosoma mansoni cpg binding protein 0.0035 0.0283 0.0283
Echinococcus granulosus zinc finger protein 0.0026 0.017 0.017
Schistosoma mansoni hypothetical protein 0.0048 0.0443 0.0443
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0117 0.0117
Echinococcus multilocularis expressed conserved protein 0.0112 0.1237 0.1237
Echinococcus granulosus death domain containing protein 0.0038 0.0326 0.0326
Onchocerca volvulus 0.0029 0.0208 0.3611
Brugia malayi hypothetical protein 0.0048 0.0443 0.0443
Brugia malayi Doublecortin family protein 0.0048 0.0443 0.0443
Trichomonas vaginalis malate dehydrogenase, putative 0.0758 0.9253 1
Echinococcus granulosus L lactate dehydrogenase B chain 0.0819 1 1
Schistosoma mansoni hypothetical protein 0.0494 0.5976 0.5976
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0038 0.0326 0.0326
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0762 0.0762
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0117 0.0117
Echinococcus granulosus histone lysine methyltransferase setb 0.0021 0.0117 0.0117
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0038 0.0326 0.0326
Schistosoma mansoni zinc finger protein 0.0026 0.017 0.017
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.023 0.0249
Schistosoma mansoni hypothetical protein 0.0049 0.0462 0.0462
Schistosoma mansoni L-lactate dehydrogenase 0.0819 1 1
Brugia malayi cytochrome P450 0.0014 0.0023 0.0023
Mycobacterium leprae putative cytochrome p450 0.0014 0.0023 0.0025
Echinococcus multilocularis Polycystic kidney disease protein 0.0048 0.0443 0.0443
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.1349 0.1349
Echinococcus multilocularis malate dehydrogenase 0.0695 0.8464 0.8464
Mycobacterium tuberculosis Probable malate dehydrogenase Mdh 0.0758 0.9253 1
Schistosoma mansoni hypothetical protein 0.0049 0.0462 0.0462
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0575 0.0575
Schistosoma mansoni polycystin 1-related 0.0048 0.0443 0.0443
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.1959 0.1959
Onchocerca volvulus 0.0035 0.0283 0.4917
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0014 0.0023 0.0025
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0758 0.9253 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0048 0.0443 0.0443
Loa Loa (eye worm) hypothetical protein 0.0046 0.0427 0.0427
Plasmodium falciparum LCCL domain-containing protein 0.0048 0.0443 0.0443
Toxoplasma gondii cytochrome p450 superfamily protein 0.0014 0.0023 0.0023

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 1.719 um PUBCHEM_BIOASSAY: Name: High Throughput Screen to Identify Compounds that increase expression of NF-kB in Human Neuronal Cells - Dose Response. (Class of assay: confirmatory) [Related pubchem assays: 1239 ] ChEMBL. No reference
Potency (functional) 0.1 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.223 uM PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators: Initial hit validation from the primary screen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485297, AID485316] ChEMBL. No reference
Potency (functional) 0.223 uM PubChem BioAssay. qHTS Assay for Rab9 Promoter Activators: Hit Validation Using Firefly Luciferase Read-Out for Rab9. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.2807 uM PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators: Initial hit validation from the primary screen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485313, AID485315] ChEMBL. No reference
Potency (functional) 0.2807 uM PubChem BioAssay. qHTS Assay for Rab9 Promoter Activators: Hit Validation Using Firefly Luciferase Read-Out for NPC1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.2807 uM PubChem BioAssay. qHTS Assay for NPC1 Promoter Activators: Hit Validation Using Firefly Luciferase Read-Out for NPC1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.2807 uM PubChem BioAssay. qHTS Assay for NPC1 Promoter Activators: Hit Validation Using Firefly Luciferase Read-Out for Rab9. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.3548 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.3981 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.5623 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.122 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 12-hLO (12-human lipoxygenase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.6944 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 1.8526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 5.0119 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702] ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (binding) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 16.416 uM PubChem BioAssay. qHTS Assay for NPC1 Promoter Activators: Hit Validation Using Renila Luciferase Read-Out for Rab9. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.416 uM PubChem BioAssay. qHTS Assay for NPC1 Promoter Activators: Hit Validation Using Renila Luciferase Read-Out for NPC1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.4191 uM PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators: Hit Validation Using Renilla Luciferase Read-Out for Rab9. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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