Detailed information for compound 1648444

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 352.701 | Formula: C10H11BrClN3S2
  • H donors: 0 H acceptors: 0 LogP: 4.06 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cccc(c1)/N=c/1\ssc(n1)N(C)C.Br
  • InChi: 1S/C10H10ClN3S2.BrH/c1-14(2)10-13-9(15-16-10)12-8-5-3-4-7(11)6-8;/h3-6H,1-2H3;1H/b12-9-;
  • InChiKey: GYHPIJXFPKXVPT-MWMYENNMSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Trypanosoma brucei hypothetical protein, conserved Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens huntingtin Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens multiple endocrine neoplasia I No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Starlite/ChEMBL No references
Homo sapiens adrenoceptor beta 2, surface Starlite/ChEMBL No references
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Echinococcus granulosus L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Treponema pallidum fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania infantum hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma congolense HpcH/HpaI aldolase/citrate lyase family, putative Get druggable targets OG5_146801 All targets in OG5_146801
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Leishmania major hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania donovani HpcH/HpaI aldolase/citrate lyase family, putative Get druggable targets OG5_146801 All targets in OG5_146801
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129301 All targets in OG5_129301
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K00142 aminoadipate-semialdehyde dehydrogenase [EC1.2.1.31], putative Get druggable targets OG5_129301 All targets in OG5_129301
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase Get druggable targets OG5_129301 All targets in OG5_129301
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Cryptosporidium hominis proteinx0005 Get druggable targets OG5_129301 All targets in OG5_129301
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum expressed protein Get druggable targets OG5_129301 All targets in OG5_129301
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Leishmania mexicana hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei gambiense hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_129301 All targets in OG5_129301
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia Fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium parvum phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Onchocerca volvulus 4'-phosphopantetheinyl transferase ffp   224 aa 186 aa 26.3 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Trichomonas vaginalis conserved hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 197 aa 22.3 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Mycobacterium ulcerans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 26.9 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Entamoeba histolytica hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 198 aa 28.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0116 0.0126 0.1817
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0006 0.0064
Loa Loa (eye worm) hypothetical protein 0.0021 0.0017 0.0219
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.0124 0.0122
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.04 0.5673
Trichomonas vaginalis PIKK family atypical protein kinase 0.034 0.0385 0.5582
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0027 0.0073
Loa Loa (eye worm) phosphatidylinositol 3 0.0116 0.0126 0.181
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0116 0.0126 0.183
Plasmodium vivax SET domain protein, putative 0.0037 0.0035 0.2641
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0603 0.0689 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.0191 1
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0006 0.0061
Schistosoma mansoni smad 0.001 0.0003 0.0024
Schistosoma mansoni smad1 5 8 and 0.001 0.0003 0.0024
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0116 0.0126 0.181
Trichomonas vaginalis PIKK family atypical protein kinase 0.0603 0.0689 1
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0116 0.0126 0.0124
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0263 0.0296 0.0294
Plasmodium vivax hypothetical protein, conserved 0.0116 0.0126 1
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0603 0.0689 0.0688
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0025 0.0065
Entamoeba histolytica hypothetical protein 0.034 0.0385 0.5578
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0027 0.0371
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0025 0.1233
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0006 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0116 0.0126 0.1817
Trypanosoma brucei polo-like protein kinase 0.0114 0.0124 0.1798
Echinococcus granulosus L aminoadipate semialdehyde 0.01 0.0108 0.0106
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0252 0.0284 0.4101
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0116 0.0126 0.0356
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0116 0.0126 0.1817
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0006 0.0064
Schistosoma mansoni cpg binding protein 0.0037 0.0034 0.0475
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0025 0.0065
Loa Loa (eye worm) hypothetical protein 0.0379 0.043 0.6232
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0006 0.0064
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0116 0.0126 1
Trichomonas vaginalis ran, putative 0.0026 0.0022 0.0299
Trichomonas vaginalis PIKK family atypical protein kinase 0.0603 0.0689 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.0003 0.0002
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0025 0.034
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.1125 0.1123
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.04 0.5802
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0603 0.0689 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.04 0.5802
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0056 0.0788
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0116 0.0126 0.0124
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0025 0.0065
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0042 0.0041
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0062 0.0872
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0006 0.0004
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0116 0.0126 0.1817
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0006 0.0059
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.0124 0.1778
Trichomonas vaginalis conserved hypothetical protein 0.0379 0.043 0.6235
Trichomonas vaginalis PIKK family atypical protein kinase 0.034 0.0385 0.5582
Schistosoma mansoni hypothetical protein 0.0263 0.0296 0.428
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0032 0.0468
Onchocerca volvulus 0.0029 0.0025 0.0726
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0057 0.0817
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.0422 0.6114
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0056 0.0788
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0025 0.1233
Brugia malayi hypothetical protein 0.0043 0.0042 0.059
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0006 0.0004
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0159 0.2285
Schistosoma mansoni ran 0.0026 0.0022 0.029
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0006 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0006 0.0064
Trichomonas vaginalis PIKK family atypical protein kinase 0.0603 0.0689 1
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.003 0.0026 0.007
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0116 0.0126 0.181
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0116 0.0126 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0006 0.0064
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0116 0.0126 0.181
Onchocerca volvulus 0.0287 0.0324 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0116 0.0126 0.181
Loa Loa (eye worm) hypothetical protein 0.0037 0.0035 0.0478
Schistosoma mansoni hypothetical protein 0.0372 0.0422 0.6114
Leishmania major phosphatidylinositol 3-kinase, putative 0.0603 0.0689 0.1897
Loa Loa (eye worm) phosphatidylinositol 3 0.0603 0.0689 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.034 0.0385 0.5582
Trichomonas vaginalis PIKK family atypical protein kinase 0.0603 0.0689 1
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0116 0.0126 0.181
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0025 0.034
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0116 0.0126 0.181
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0028 0.0025 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0056 0.0054
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0116 0.0126 0.1817
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0116 0.0126 0.183
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.003 0.0026 0.1353
Loa Loa (eye worm) hypothetical protein 0.0035 0.0032 0.0445
Leishmania major phosphatidylinositol kinase, putative 0.0116 0.0126 0.0343
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0006 0.0004
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0014 0.0179
Loa Loa (eye worm) MH1 domain-containing protein 0.001 0.0003 0.0024
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0037 0.0035 0.0478
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0006 0.0064
Leishmania major phosphopantetheinyl transferase-like protein 0.0028 0.0025 0.0063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0603 0.0689 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0006 0.0004
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0056 0.0788
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0116 0.0126 0.0124
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0025 0.1844
Schistosoma mansoni mixed-lineage leukemia protein mll 0.001 0.0003 0.0026
Brugia malayi Importin beta-1 subunit 0.0035 0.0032 0.0445
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0025 0.1233
Trichomonas vaginalis PIKK family atypical protein kinase 0.0603 0.0689 1
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0124 0.1786
Brugia malayi hypothetical protein 0.0148 0.0163 0.2348
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0014 0.0012
Schistosoma mansoni coup transcription factor 0.0012 0.0006 0.0064
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.034 0.0385 0.5578
Echinococcus granulosus dnaJ subfamily B 0.0494 0.0563 0.0562
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0603 0.0689 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.0163 0.2348
Echinococcus granulosus importin subunit beta 1 0.0035 0.0032 0.0031
Loa Loa (eye worm) hypothetical protein 0.0029 0.0025 0.034
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0006 0.0004
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0022 0.0057
Loa Loa (eye worm) phosphatidylinositol 3 0.0603 0.0689 1
Echinococcus multilocularis Smad4 0.001 0.0003 0.0002
Giardia lamblia GTOR 0.0603 0.0689 1
Schistosoma mansoni cpg binding protein 0.0035 0.0032 0.0442
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0002 0.0009
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0006 0.0064
Loa Loa (eye worm) hypothetical protein 0.0148 0.0163 0.2348
Trichomonas vaginalis PIKK family atypical protein kinase 0.0603 0.0689 1
Echinococcus multilocularis serine protein kinase ATM 0.034 0.0385 0.0384
Echinococcus multilocularis citrate lyase subunit beta protein 0.003 0.0026 0.0025
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.04 0.5802
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0064
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0006 0.0004
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0035 0.0033
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0116 0.0126 0.1817
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0025 0.0343
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0006 0.0136
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0025 0.1233
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.003 0.0026 0.1291
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0116 0.0126 0.183
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.0035 0.0033
Schistosoma mansoni hypothetical protein 0.0014 0.0008 0.0088
Brugia malayi ecdysteroid receptor 0.0012 0.0006 0.0064
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0025 0.034
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.0124 0.0337
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.0008 0.0006
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0006 0.0064
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0006 0.0064
Trichomonas vaginalis PIKK family atypical protein kinase 0.0603 0.0689 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0064
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0006 0.0064
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0022 0.029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0603 0.0689 1
Loa Loa (eye worm) hypothetical protein 0.0116 0.0126 0.181
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0008 0.0002 0.0071
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0124 0.1786
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.0124 0.1778
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0116 0.0126 0.1817
Trichomonas vaginalis PIKK family atypical protein kinase 0.0603 0.0689 1
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0116 0.0126 0.181
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0008 0.0002 0.0071
Brugia malayi FAT domain containing protein 0.0263 0.0296 0.428
Brugia malayi MH2 domain containing protein 0.001 0.0003 0.0024
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0116 0.0126 0.0356
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0006 0.0064
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0015 0.0786
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.004 0.0551
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.0124 0.1778
Schistosoma mansoni importin beta-1 0.0035 0.0032 0.0445
Loa Loa (eye worm) hypothetical protein 0.0263 0.0296 0.428
Schistosoma mansoni hypothetical protein 0.0043 0.0042 0.059
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0025 0.034
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0015 0.0786
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0116 0.0126 0.183
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0064
Entamoeba histolytica hypothetical protein 0.0043 0.0042 0.059
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.865 1 1
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0116 0.0126 0.0356
Toxoplasma gondii target of rapamycin (TOR), putative 0.0603 0.0689 1
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0006 0.0064
Mycobacterium ulcerans hypothetical protein 0.003 0.0026 0.1291
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0017 0.0792
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0603 0.0689 0.197
Echinococcus granulosus smad 0.001 0.0003 0.0002
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0116 0.0126 0.181
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.0124 0.3795
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0116 0.0126 0.183
Leishmania major GTP-binding protein, putative 0.0026 0.0022 0.0055
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0075 0.0079 0.1119
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.0003 0.0002
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0025 0.0343
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0116 0.0126 0.181
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0116 0.0126 0.0356
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0116 0.0126 0.1565
Schistosoma mansoni smad1 5 8 and 0.001 0.0003 0.0024
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0116 0.0126 0.1817
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0116 0.0126 0.0124
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0042 0.059
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0014 0.0012
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0006 0.0004
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0032 0.0445
Trichomonas vaginalis conserved hypothetical protein 0.0224 0.0251 0.3633
Schistosoma mansoni hypothetical protein 0.0019 0.0014 0.0179
Trichomonas vaginalis PIKK family atypical protein kinase 0.0603 0.0689 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0025 0.0066
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.0124 0.035
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0022 0.029
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0006 0.0004
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0006 0.0004
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0006 0.0064
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0025 0.1233
Giardia lamblia Phosphatidylinositol 4-kinase 0.0116 0.0126 0.1565
Trichomonas vaginalis PIKK family atypical protein kinase 0.0603 0.0689 1
Brugia malayi nuclear receptor NHR-88 0.0012 0.0006 0.0064
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0022 0.1602
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0124 0.1786
Trichomonas vaginalis conserved hypothetical protein 0.0263 0.0296 0.4286
Schistosoma mansoni Smad4 0.001 0.0003 0.0024
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0116 0.0126 0.1565
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0017 0.1208
Trichomonas vaginalis PIKK family atypical protein kinase 0.0603 0.0689 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0603 0.0689 1
Echinococcus multilocularis mixed lineage leukemia protein mll 0.001 0.0003 0.0002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0056 0.0788
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.0191 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0017 0.0219
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0014 0.0012
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0025 0.1295
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0603 0.0689 0.1897
Trichomonas vaginalis PIKK family atypical protein kinase 0.034 0.0385 0.5582
Schistosoma mansoni cpg binding protein 0.0037 0.0034 0.0475
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.04 0.5802
Trichomonas vaginalis PIKK family atypical protein kinase 0.0603 0.0689 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0603 0.0689 1
Leishmania major phosphatidylinositol 4-kinase, putative 0.0116 0.0126 0.0343
Schistosoma mansoni hypothetical protein 0.0041 0.004 0.0551
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0116 0.0126 0.0356
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0603 0.0689 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0025 0.034
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0116 0.0126 1
Echinococcus granulosus snurportin 1 0.0372 0.0422 0.042
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0022 0.0057
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0116 0.0126 0.181
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0006 0.0004
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0002 0.0024
Mycobacterium leprae conserved hypothetical protein 0.0116 0.0126 0.6556
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0006 0.0004
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0062 0.0872
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0116 0.0126 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0056 0.0054
Brugia malayi CXXC zinc finger family protein 0.0035 0.0032 0.0442
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0006 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0006 0.0064
Trichomonas vaginalis PIKK family atypical protein kinase 0.0603 0.0689 1
Leishmania major hypothetical protein, conserved 0.003 0.0027 0.007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0006 0.0064
Entamoeba histolytica hypothetical protein 0.0043 0.0042 0.059
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0116 0.0126 0.181
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0006 0.0004
Echinococcus multilocularis smad 0.001 0.0003 0.0002
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.034 0.0385 0.1099
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0014 0.0012
Trichomonas vaginalis set domain proteins, putative 0.0287 0.0324 0.469
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0116 0.0126 0.181
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0603 0.0689 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0025 0.034
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0116 0.0126 0.181
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0006 0.0064
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0116 0.0126 0.0124
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.003 0.0026 0.1291
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.0003 0.0002
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0008 0.0002 0.0024
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0027 0.0073
Onchocerca volvulus 0.0116 0.0126 0.3862
Mycobacterium ulcerans hypothetical protein 0.0029 0.0025 0.1233
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0025 0.1295
Brugia malayi MH1 domain containing protein 0.001 0.0003 0.0024
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0116 0.0126 0.181
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0006 0.0064
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0006 0.0064
Trichomonas vaginalis PIKK family atypical protein kinase 0.034 0.0385 0.5582
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0028 0.0025 0.0334
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.003 0.0026 0.007
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0006 0.0004
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0224 0.0251 0.0714
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.034 0.0385 0.5589
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0124 0.1786
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0179
Loa Loa (eye worm) phosphatidylinositol 3 0.0116 0.0126 0.181
Mycobacterium tuberculosis Conserved hypothetical protein 0.0116 0.0126 0.6581
Trichomonas vaginalis PIKK family atypical protein kinase 0.0603 0.0689 1
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0603 0.0689 0.0688
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0006 0.0064
Trichomonas vaginalis PIKK family atypical protein kinase 0.0603 0.0689 1
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0116 0.0126 0.181
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.034 0.0385 0.1099
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.034 0.0385 0.5578
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0116 0.0126 0.181
Mycobacterium leprae conserved hypothetical protein 0.0028 0.0025 0.1209
Entamoeba histolytica hypothetical protein 0.0043 0.0042 0.059
Schistosoma mansoni fkbp-rapamycin associated protein 0.034 0.0385 0.5578
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0124 0.1786
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0025 0.1233
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0603 0.0689 1
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0002 0.0009
Giardia lamblia Kinase, PLK 0.0114 0.0124 0.1533
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.04 0.5798
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0006 0.0136
Plasmodium vivax hypothetical protein 0.0116 0.0126 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0006 0.0064
Loa Loa (eye worm) phosphatidylinositol 3 0.0116 0.0126 0.181
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0032 0.0031
Brugia malayi steroid hormone receptor 0.0012 0.0006 0.0064
Trichomonas vaginalis PIKK family atypical protein kinase 0.034 0.0385 0.5582
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0028 0.0025 0.1209
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0056 0.0788
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0025 0.1233
Trichomonas vaginalis PIKK family atypical protein kinase 0.0379 0.043 0.6235
Brugia malayi MH1 domain containing protein 0.001 0.0003 0.0024
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0603 0.0689 1
Schistosoma mansoni ran 0.0026 0.0022 0.029
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0032 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.034 0.0385 0.5582
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0116 0.0126 0.0356
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0056 0.0054
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0017 0.1208
Schistosoma mansoni hypothetical protein 0.0019 0.0014 0.0179
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0064
Brugia malayi hypothetical protein 0.003 0.0027 0.0371
Loa Loa (eye worm) hypothetical protein 0.0021 0.0017 0.0219
Onchocerca volvulus Huntingtin homolog 0.0148 0.0163 0.5012
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0025 0.1844
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0603 0.0689 0.197
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0603 0.0689 1
Brugia malayi MH2 domain containing protein 0.0144 0.0159 0.2285
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0022 0.029
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0116 0.0126 0.181
Giardia lamblia Hypothetical protein 0.0116 0.0126 0.1565
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0022 0.002
Schistosoma mansoni smad1 5 8 and 0.001 0.0003 0.0024
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.0025 0.0357
Onchocerca volvulus 0.0037 0.0035 0.102
Echinococcus multilocularis GPCR, family 2 0.0019 0.0014 0.0012
Echinococcus granulosus Smad4 0.001 0.0003 0.0002
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0027 0.2049
Trichomonas vaginalis Citrate lyase beta chain, putative 0.003 0.0026 0.0365
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.034 0.0385 0.5578
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0028 0.0025 0.1209
Loa Loa (eye worm) hypothetical protein 0.0021 0.0017 0.0219
Loa Loa (eye worm) phosphatidylinositol 3 0.0116 0.0126 0.181
Toxoplasma gondii FATC domain-containing protein 0.034 0.0385 0.5578
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0006 0.0064
Schistosoma mansoni hypothetical protein 0.0116 0.0126 0.181
Schistosoma mansoni kinase 0.0058 0.0059 0.0834
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0006 0.0064
Plasmodium falciparum importin beta, putative 0.0035 0.0032 0.2456
Brugia malayi MH2 domain containing protein 0.001 0.0003 0.0024
Loa Loa (eye worm) phosphatidylinositol kinase 0.0116 0.0126 0.181
Schistosoma mansoni hypothetical protein 0.0494 0.0563 0.8171
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0014 0.0179
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.04 0.5802
Leishmania major hypothetical protein, unknown function 0.0116 0.0126 0.0343
Leishmania major phosphatidylinositol kinase related protein, putative 0.0116 0.0126 0.0343
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0002 0.0071
Echinococcus granulosus serine protein kinase ATM 0.034 0.0385 0.0384
Loa Loa (eye worm) hypothetical protein 0.006 0.0062 0.0872
Trichomonas vaginalis PIKK family atypical protein kinase 0.0116 0.0126 0.1817
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0064
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0603 0.0689 0.0688
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0116 0.0126 0.181
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0028 0.0025 0.1271
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0002 0.0071
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0057 0.0817
Leishmania major hypothetical protein, conserved 0.3141 0.3626 1
Entamoeba histolytica hypothetical protein 0.0116 0.0126 0.181
Echinococcus multilocularis L aminoadipate semialdehyde 0.01 0.0108 0.0106
Plasmodium vivax importin-beta 2, putative 0.0035 0.0032 0.2456
Entamoeba histolytica Ran family GTPase 0.0026 0.0022 0.029
Entamoeba histolytica hypothetical protein 0.0043 0.0042 0.059
Echinococcus multilocularis Zinc finger, PHD finger 0.0116 0.0126 0.0124
Loa Loa (eye worm) hypothetical protein 0.0041 0.004 0.0551
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0042 0.0041
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0006 0.0004
Onchocerca volvulus 0.0116 0.0126 0.3862
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0116 0.0126 0.1817
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0032 0.0442
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0017 0.0857
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0006 0.0064
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0116 0.0126 0.181
Loa Loa (eye worm) hypothetical protein 0.0029 0.0025 0.034
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.0035 0.0033
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0116 0.0126 0.181
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0603 0.0689 0.0688
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0006 0.0064
Onchocerca volvulus Huntingtin homolog 0.0148 0.0163 0.5012
Brugia malayi Pre-SET motif family protein 0.0037 0.0035 0.0478
Echinococcus granulosus serine:threonine protein kinase SMG1 0.034 0.0385 0.0384
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0008 0.0002 0.0071
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0006 0.0064
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0116 0.0126 0.181
Loa Loa (eye worm) hypothetical protein 0.003 0.0027 0.0371
Loa Loa (eye worm) hypothetical protein 0.0021 0.0017 0.0219
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0003 0.0002
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0116 0.0126 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0603 0.0689 0.1897
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0603 0.0689 0.197
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0008 0.0002 0.0071
Echinococcus granulosus cpg binding protein 0.0037 0.0034 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0006 0.0064
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0116 0.0126 0.0124
Brugia malayi Pre-SET motif family protein 0.0252 0.0284 0.4101
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0116 0.0126 0.181
Trypanosoma cruzi hypothetical protein, conserved 0.0257 0.0289 0.0824
Mycobacterium ulcerans hypothetical protein 0.003 0.0026 0.1291
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0056 0.0054
Entamoeba histolytica hypothetical protein 0.0028 0.0025 0.0334
Loa Loa (eye worm) hypothetical protein 0.0116 0.0126 0.181
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0027 0.2049
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0116 0.0126 0.181
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0603 0.0689 0.1897
Mycobacterium tuberculosis Conserved protein 0.003 0.0026 0.1353
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0008 0.0002 0.0071
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0022 0.0313
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0015 0.0786
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.04 0.5802
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.04 0.5802
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.034 0.0385 0.5578
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.0124 0.1778
Brugia malayi Smad1 0.001 0.0003 0.0024
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0116 0.0126 0.0124
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0116 0.0126 0.1817
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0116 0.0126 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0067 0.007 0.0987
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0008 0.0002 0.0071
Leishmania major phosphatidylinositol 3-kinase, putative 0.0116 0.0126 0.0343
Trichomonas vaginalis PIKK family atypical protein kinase 0.0116 0.0126 0.1817
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0027 0.2049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0603 0.0689 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0006 0.0064
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.01 0.0108 0.1548
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0022 0.002
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0116 0.0126 0.0356
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0006 0.0064
Trichomonas vaginalis PIKK family atypical protein kinase 0.0603 0.0689 1
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0027 0.0394
Loa Loa (eye worm) hypothetical protein 0.0224 0.0251 0.3627
Entamoeba histolytica hypothetical protein 0.0028 0.0025 0.0334
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.0008 0.0006
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.0191 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0064
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.0563 0.0562
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0006 0.0064
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0002 0.0071
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0002 0.0071
Trypanosoma cruzi target of rapamycin kinase 3 0.0603 0.0689 0.197
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0006 0.0064
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0116 0.0126 0.181
Trypanosoma brucei hypothetical protein, conserved 0.0257 0.0289 0.4196
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0603 0.0689 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0603 0.0689 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0006 0.0004
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0064
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0116 0.0126 0.0124
Trichomonas vaginalis PIKK family atypical protein kinase 0.0603 0.0689 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0603 0.0689 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0006 0.0064
Loa Loa (eye worm) hypothetical protein 0.01 0.0108 0.1548
Trichomonas vaginalis PIKK family atypical protein kinase 0.0603 0.0689 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0006 0.0004
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0116 0.0126 0.0124
Onchocerca volvulus 0.01 0.0108 0.3304
Trypanosoma cruzi hypothetical protein, conserved 0.3025 0.3492 1
Echinococcus granulosus citrate lyase subunit beta protein 0.003 0.0026 0.0025
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0022 0.1602
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0025 0.1233
Brugia malayi RNA, U transporter 1 0.0099 0.0107 0.1525
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0015 0.0786
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0603 0.0689 1
Echinococcus multilocularis 0.0116 0.0126 0.0124
Entamoeba histolytica hypothetical protein 0.0116 0.0126 0.181
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.0003 0.0002
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.04 0.5802
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.003 0.0026 0.1291
Entamoeba histolytica hypothetical protein 0.0116 0.0126 0.181
Trichomonas vaginalis PIKK family atypical protein kinase 0.0224 0.0251 0.3633
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0116 0.0126 0.0124
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.01 0.0108 0.1548
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.04 1
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0116 0.0126 0.0124
Trichomonas vaginalis PIKK family atypical protein kinase 0.0603 0.0689 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.04 0.5798
Leishmania major hypothetical protein, conserved 0.0257 0.0289 0.0793
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0116 0.0126 0.0356
Trypanosoma cruzi hypothetical protein, conserved 0.0257 0.0289 0.0824
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0116 0.0126 0.0124
Trichomonas vaginalis PIKK family atypical protein kinase 0.034 0.0385 0.5582
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.003 0.0026 0.0068
Onchocerca volvulus 0.0035 0.0032 0.0944
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0159 0.2285
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0035 0.0478
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0116 0.0126 0.1817
Brugia malayi hypothetical protein 0.002 0.0015 0.0189
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0035 0.0478
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0006 0.0004
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0116 0.0126 0.181
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0603 0.0689 0.1897
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0025 0.0343
Echinococcus granulosus GPCR family 2 0.0019 0.0014 0.0012
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0263 0.0296 0.0294
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0028 0.0025 0.0334
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0025 0.1233
Entamoeba histolytica protein kinase rad3, putative 0.034 0.0385 0.5578
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0032 0.0468
Echinococcus multilocularis cpg binding protein 0.0037 0.0034 0.0033
Loa Loa (eye worm) Smad1 0.001 0.0003 0.0024
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.0124 0.035
Echinococcus granulosus mixed lineage leukemia protein mll 0.001 0.0003 0.0002
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0116 0.0126 0.1817
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.0003 0.0024
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0008 0.0002 0.0071
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0014 0.0179
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0006 0.0136
Trichomonas vaginalis PIKK family atypical protein kinase 0.0603 0.0689 1
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0124 0.1786
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0116 0.0126 0.0356
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0116 0.0126 0.181
Loa Loa (eye worm) MH2 domain-containing protein 0.001 0.0003 0.0024
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0116 0.0126 0.181
Entamoeba histolytica hypothetical protein 0.0116 0.0126 0.181
Brugia malayi nuclear hormone receptor 0.0012 0.0006 0.0064
Onchocerca volvulus 0.0012 0.0006 0.0136
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0025 0.034
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0006 0.0064
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0116 0.0126 0.1817
Trichomonas vaginalis PIKK family atypical protein kinase 0.0603 0.0689 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0035 0.0478
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0116 0.0126 0.0343
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0124 0.1786
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0006 0.0004
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.0124 0.0122
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0116 0.0126 0.181
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0028 0.0025 1
Leishmania major importin beta-1 subunit, putative 0.0028 0.0025 0.0063
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0116 0.0126 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0006 0.0064
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0379 0.043 0.6232
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0062 0.0872
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.0035 0.0478
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0379 0.043 0.6241
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0003 0.0002
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0006 0.0064
Loa Loa (eye worm) hypothetical protein 0.034 0.0385 0.5578
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.034 0.0385 0.0384
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0006 0.0064
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0116 0.0126 0.1817
Echinococcus multilocularis snurportin 1 0.0372 0.0422 0.042
Schistosoma mansoni hypothetical protein 0.0019 0.0014 0.0179
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0603 0.0689 0.197
Schistosoma mansoni hypothetical protein 0.0019 0.0014 0.0179
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0116 0.0126 0.0356
Trichomonas vaginalis PIKK family atypical protein kinase 0.0603 0.0689 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0603 0.0689 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0116 0.0126 0.181

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -5.427 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.892 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.888 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.735 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.727 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.551 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.416 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.2818 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 0.3981 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.4467 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.5012 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.7079 uM PUBCHEM_BIOASSAY: qHTS assay of beta-arrestin-biased ligands of beta2-adrenergic receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485366, AID485386, AID504448, AID504454, AID504459] ChEMBL. No reference
Potency (functional) = 0.8913 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.0323 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 1.0418 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 1.5849 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.2387 uM PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.3323 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 3.3808 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 4.609 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) 5.1735 uM PubChem BioAssay. qHTS for Inhibitors of TGF-b: Confirmation of Cherry Picks. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 6.7016 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.5539 uM PUBCHEM_BIOASSAY: qHTS of small molecules that selectively kill Giardia lamblia: Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540272] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Leishmania Mexicana Pyruvate Kinase (LmPK). (Class of assay: confirmatory) [Related pubchem assays: 1379 ] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Leishmania Mexicana Pyruvate Kinase (LmPK). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 25.1189 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. qHTS for Inhibitors of TGF-b: CCL64 Cells Orthogonal Assay for Cherry Picks. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 63.0957 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Saccharomyces cerevisiae ChEMBL23
Plasmodium falciparum ChEMBL23
Giardia lamblia

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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