Detailed information for compound 177019

Basic information

Technical information
  • TDR Targets ID: 177019
  • Name: (2,6-dimethylphenyl)-[4-methyl-4-[4-[[4-(trif luoromethoxy)phenyl]methyl]piperidin-1-yl]pip eridin-1-yl]methanone
  • MW: 488.585 | Formula: C28H35F3N2O2
  • H donors: 0 H acceptors: 1 LogP: 6.77 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cccc(c1C(=O)N1CCC(CC1)(C)N1CCC(CC1)Cc1ccc(cc1)OC(F)(F)F)C
  • InChi: 1S/C28H35F3N2O2/c1-20-5-4-6-21(2)25(20)26(34)32-17-13-27(3,14-18-32)33-15-11-23(12-16-33)19-22-7-9-24(10-8-22)35-28(29,30)31/h4-10,23H,11-19H2,1-3H3
  • InChiKey: XRUMZMCHUHDEQQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2,6-dimethylphenyl)-[4-methyl-4-[4-[[4-(trifluoromethoxy)phenyl]methyl]-1-piperidyl]-1-piperidyl]methanone
  • (2,6-dimethylphenyl)-[4-methyl-4-[4-[[4-(trifluoromethoxy)phenyl]methyl]-1-piperidinyl]-1-piperidinyl]methanone
  • (2,6-dimethylphenyl)-[4-methyl-4-[4-[4-(trifluoromethoxy)benzyl]piperidino]piperidino]methanone
  • (2,6-dimethylphenyl)-[4-methyl-4-[4-[4-(trifluoromethoxy)benzyl]-1-piperidyl]-1-piperidyl]methanone
  • 1,4'-Bipiperidine, 1'-(2,6-dimethylbenzoyl)-4'-methyl-4-[[4-(trifluoromethoxy)phenyl]methyl]-
  • AIDS-185419
  • AIDS185419

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus chemokine (C-C motif) receptor 5 Starlite/ChEMBL References
Homo sapiens chemokine (C-C motif) receptor 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus pyroglutamylated rfamide peptide receptor chemokine (C-C motif) receptor 5 354 aa 379 aa 20.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) T-complex protein 1 0.0025 0.003 0.0029
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.033 0.0628 0.0628
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.001 0.0002 0.0001
Onchocerca volvulus 0.0984 0.1907 1
Echinococcus granulosus Protein kinase C brain isozyme 0.0011 0.0003 0.0003
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.033 0.0628 0.0832
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.033 0.0628 0.0627
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.033 0.0628 1
Schistosoma mansoni bromodomain containing protein 0.0073 0.0125 0.0125
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0011 0.0003 0.0003
Schistosoma mansoni fkbp-rapamycin associated protein 0.0968 0.1876 0.1876
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.033 0.0628 0.0627
Echinococcus multilocularis muscleblind protein 0.0153 0.028 0.028
Trichomonas vaginalis PIKK family atypical protein kinase 0.2764 0.5391 0.5391
Trichomonas vaginalis adenylate cyclase, putative 0.001 0.0002 0.0001
Plasmodium falciparum acyl-CoA synthetase 0.0148 0.0271 0.4217
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0058 0.0095 0.1371
Schistosoma mansoni ran 0.0023 0.0026 0.0026
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.001 0.0002 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.276 0.5383 0.5383
Loa Loa (eye worm) hypothetical protein 0.0198 0.0369 0.0368
Trypanosoma cruzi ISWI complex protein 0.0017 0.0016 0.0005
Mycobacterium ulcerans acyl-CoA synthetase 0.0198 0.0369 1
Schistosoma mansoni serine/threonine protein kinase 0.0011 0.0003 0.0003
Loa Loa (eye worm) inositol-1 0.0042 0.0064 0.0063
Onchocerca volvulus 0.002 0.002 0.0103
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1716 0.3341 0.3341
Echinococcus granulosus cpg binding protein 0.0023 0.0027 0.0027
Trichomonas vaginalis guanylate cyclase, putative 0.001 0.0002 0.0001
Brugia malayi Muscleblind-like protein 0.0153 0.028 0.0279
Echinococcus granulosus protein kinase c iota type 0.0011 0.0003 0.0003
Schistosoma mansoni serine/threonine-protein kinase 0.0023 0.0026 0.0026
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.5118 1 1
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.001 0.0001 0.0001
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0061 0.0102 0.0101
Schistosoma mansoni serine/threonine protein kinase 0.0011 0.0003 0.0003
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.001 0.0002 0.0001
Echinococcus multilocularis fk506 binding protein 0.0061 0.0102 0.0102
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0058 0.0095 0.1493
Trichomonas vaginalis guanylate cyclase, putative 0.001 0.0002 0.0001
Brugia malayi Inositol-1 0.0042 0.0064 0.0063
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0011 0.0003 0.0003
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0047 0.0046
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.033 0.0628 0.0627
Trichomonas vaginalis PIKK family atypical protein kinase 0.3323 0.6485 0.6485
Trichomonas vaginalis guanylate cyclase, putative 0.001 0.0002 0.0001
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0047 0.0046
Loa Loa (eye worm) hypothetical protein 0.0148 0.0271 0.027
Trichomonas vaginalis PIKK family atypical protein kinase 0.1716 0.3341 0.3341
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0025 0.003 0.0029
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0036 0.0051 0.0049
Trichomonas vaginalis chaperonin, putative 0.0025 0.003 0.0029
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0021 0.0022 0.0191
Trichomonas vaginalis PIKK family atypical protein kinase 0.4071 0.795 0.795
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0015 0.0011 0.0051
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0036 0.0051 0.0051
Loa Loa (eye worm) phosphatidylinositol 3 0.1716 0.3341 0.3341
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.033 0.0628 0.0832
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.2126 0.4143 0.4141
Plasmodium vivax hypothetical protein, conserved 0.033 0.0628 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0042 0.004
Schistosoma mansoni cpg binding protein 0.0023 0.0027 0.0027
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2315 0.4514 0.4514
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0015 0.0011 0.0008
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0015 0.0011 0.001
Echinococcus multilocularis muscleblind protein 1 0.0153 0.028 0.028
Leishmania major acetyl-CoA synthetase, putative 0.0058 0.0095 0.0085
Loa Loa (eye worm) hypothetical protein 0.0031 0.0042 0.0041
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1716 0.3341 0.334
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0061 0.0102 0.0102
Echinococcus multilocularis cpg binding protein 0.0023 0.0027 0.0027
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.033 0.0628 0.0618
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0022 0.0025 0.0024
Echinococcus granulosus cGMP dependent protein kinase 1 0.0015 0.0011 0.0011
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0053 0.0085 0.0085
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0058 0.0095 0.2362
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.033 0.0628 0.0627
Plasmodium vivax hypothetical protein 0.033 0.0628 1
Echinococcus granulosus guanine nucleotide binding protein subunit 0.001 0.0001 0.0001
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.033 0.0628 0.0627
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0148 0.0271 0.7267
Leishmania major importin beta-1 subunit, putative 0.0025 0.0031 0.002
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.033 0.0628 0.0832
Echinococcus multilocularis nervana 2 0.0021 0.0022 0.0022
Schistosoma mansoni voltage-gated potassium channel 0.0033 0.0045 0.0045
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.4075 0.7958 0.7956
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.001 0.0002 0.0001
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0061 0.0102 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0968 0.1876 0.1876
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0968 0.1876 0.1876
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.033 0.0628 0.0627
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0027 0.0034 0.0647
Brugia malayi Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog 0.0015 0.0011 0.001
Entamoeba histolytica acyl-coA synthetase, putative 0.0198 0.0369 0.0368
Loa Loa (eye worm) phosphatidylinositol 3 0.033 0.0628 0.0627
Echinococcus granulosus cGMP dependent protein kinase 0.0015 0.0011 0.0011
Trichomonas vaginalis guanylate cyclase, putative 0.001 0.0002 0.0001
Loa Loa (eye worm) phosphatidylinositol 3 0.033 0.0628 0.0627
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0058 0.0095 0.1371
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.001 0.0002 0.0001
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.001 0.0002 0.0001
Onchocerca volvulus 0.033 0.0628 0.329
Trichomonas vaginalis PIKK family atypical protein kinase 0.3807 0.7433 0.7433
Loa Loa (eye worm) hypothetical protein 0.033 0.0628 0.0627
Trichomonas vaginalis PIKK family atypical protein kinase 0.3433 0.6702 0.6701
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0042 0.004
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0968 0.1876 0.1876
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0095 0.0167 0.0167
Loa Loa (eye worm) hypothetical protein 0.0148 0.0271 0.027
Leishmania major phosphatidylinositol 3-kinase, putative 0.1716 0.3341 0.3334
Brugia malayi protein kinase C II. 0.0011 0.0003 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0002 0.0001
Mycobacterium leprae conserved hypothetical protein 0.0027 0.0034 0.0512
Trichomonas vaginalis conserved hypothetical protein 0.1079 0.2093 0.2092
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0033 0.0045 0.0045
Schistosoma mansoni hypothetical protein 0.0632 0.1219 0.1219
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0015 0.0011 0.0011
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.033 0.0628 0.0627
Echinococcus granulosus hyperpolarization activated cyclic 0.0022 0.0025 0.0025
Entamoeba histolytica hypothetical protein 0.0025 0.0031 0.003
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0058 0.0095 0.1371
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.5118 1 1
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0015 0.0011 0.0011
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0198 0.0369 0.5862
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.001 0.0002 0.0001
Schistosoma mansoni tar DNA-binding protein 0.0089 0.0155 0.0155
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0038 0.0055 0.0726
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0198 0.0369 1
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.033 0.0628 0.0626
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.033 0.0628 0.0627
Mycobacterium ulcerans acyl-CoA synthetase 0.0058 0.0095 0.2362
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.001 0.0001 0.0001
Echinococcus granulosus dnaJ subfamily B 0.0283 0.0535 0.0535
Trypanosoma brucei cAMP response protein 1, putative 0.0015 0.0011 0.0008
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.001
Leishmania major pantothenate kinase subunit, putative 0.0015 0.0011 0.0001
Schistosoma mansoni serine/threonine protein kinase 0.0011 0.0003 0.0003
Onchocerca volvulus 0.0058 0.0095 0.0495
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0047 0.0046
Trichomonas vaginalis AGC family protein kinase 0.0011 0.0003 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.1716 0.3341 0.3341
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0026 0.0025
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.033 0.0628 0.0626
Mycobacterium ulcerans acyl-CoA synthetase 0.0198 0.0369 1
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.0015 0.0011 0.001
Echinococcus granulosus NDR protein kinase 0.0011 0.0003 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.3807 0.7433 0.7433
Brugia malayi PHD-finger family protein 0.003 0.0039 0.0039
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.033 0.0628 0.0618
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0058 0.0095 0.2362
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.033 0.0628 0.0832
Giardia lamblia Hypothetical protein 0.033 0.0628 0.0618
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0036 0.0051 0.1138
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0064 0.0054
Trichomonas vaginalis PIKK family atypical protein kinase 0.3807 0.7433 0.7433
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.033 0.0628 0.0628
Leishmania major GTP-binding protein, putative 0.0023 0.0026 0.0016
Trichomonas vaginalis inositol monophosphatase, putative 0.0042 0.0064 0.0063
Schistosoma mansoni serine/threonine protein kinase 0.0015 0.0011 0.0011
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0042 0.0043
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.033 0.0628 0.0627
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0015 0.0011 0.001
Brugia malayi CXXC zinc finger family protein 0.002 0.002 0.002
Echinococcus multilocularis inositol monophosphatase 1 0.0042 0.0064 0.0064
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0027 0.0034 0.0376
Brugia malayi T-complex protein 1, beta subunit 0.0025 0.003 0.0029
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0058 0.0095 0.1371
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0015 0.0011 0.0011
Echinococcus granulosus snurportin 1 0.0331 0.063 0.063
Schistosoma mansoni acetyl-CoA synthetase 0.0058 0.0095 0.0095
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0058 0.0095 0.0094
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0026 0.0025
Schistosoma mansoni hypothetical protein 0.0088 0.0155 0.0155
Schistosoma mansoni ran 0.0023 0.0026 0.0026
Mycobacterium ulcerans acyl-CoA synthetase 0.0058 0.0095 0.2362
Echinococcus granulosus expressed protein 0.001 0.0001 0.0001
Trichomonas vaginalis adenylate cyclase, putative 0.001 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0968 0.1876 0.1876
Trichomonas vaginalis immunophilin, putative 0.0061 0.0102 0.0101
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0022 0.0025 0.0025
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0113 0.0202 0.0202
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0027 0.0034 0.2544
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0031 0.003
Mycobacterium ulcerans acyl-CoA synthetase 0.0198 0.0369 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0022 0.0025 0.0025
Schistosoma mansoni serine/threonine protein kinase 0.0011 0.0003 0.0003
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0095 0.0167 0.0167
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0036 0.0051 0.066
Echinococcus granulosus L aminoadipate semialdehyde 0.0095 0.0167 0.0167
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0011 0.001
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.033 0.0628 0.0627
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0058 0.0095 0.1371
Trichomonas vaginalis guanylate cyclase, putative 0.001 0.0002 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.4071 0.795 0.795
Entamoeba histolytica PH domain containing protein kinase, putative 0.0023 0.0026 0.0026
Echinococcus multilocularis cAMP dependent protein kinase type II regulatory 0.0015 0.0011 0.0011
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.033 0.0628 0.0627
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0968 0.1876 0.1876
Loa Loa (eye worm) hypothetical protein 0.033 0.0628 0.0627
Entamoeba histolytica Ran family GTPase 0.0023 0.0026 0.0025
Onchocerca volvulus 0.0198 0.0369 0.1931
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.033 0.0628 1
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.033 0.0628 0.0618
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0968 0.1876 0.1876
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.033 0.0628 0.0628
Schistosoma mansoni camp-dependent protein kinase regulatory chain 0.0015 0.0011 0.0011
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0022 0.0025 0.0025
Loa Loa (eye worm) TAR-binding protein 0.0089 0.0155 0.0154
Entamoeba histolytica hypothetical protein 0.0082 0.0142 0.0142
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0098 0.0173 0.0172
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.001 0.0002 0.0001
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0026 0.0253
Mycobacterium ulcerans acyl-CoA synthetase 0.0058 0.0095 0.2362
Schistosoma mansoni atypical protein kinase C 0.0011 0.0003 0.0003
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.001 0.0001 0.0001
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0026 0.0016
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0058 0.0095 0.0085
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.002 0.002
Echinococcus granulosus importin subunit beta 1 0.0031 0.0042 0.0042
Echinococcus granulosus patatin phospholipase domain containing protein 0.0015 0.0011 0.0011
Entamoeba histolytica hypothetical protein 0.0082 0.0142 0.0142
Echinococcus granulosus nervana 2 0.0021 0.0022 0.0022
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0968 0.1876 0.1876
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0061 0.0102 0.0102
Trichomonas vaginalis PIKK family atypical protein kinase 0.1716 0.3341 0.3341
Loa Loa (eye worm) phosphatidylinositol 3 0.033 0.0628 0.0627
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0021 0.0022 0.0012
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.5118 1 1
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.033 0.0628 0.0618
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0015 0.0011 0.0011
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.033 0.0628 0.0628
Echinococcus multilocularis Glutaredoxin protein 5 0.0021 0.0022 0.0022
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0022 0.0025 0.0025
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0058 0.0095 0.2362
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0034 0.0034
Brugia malayi AMP-binding enzyme family protein 0.0058 0.0095 0.0094
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0011 0.0003 0.0002
Schistosoma mansoni similar to Protein C20orf152 homolog 0.0015 0.0011 0.0011
Entamoeba histolytica protein kinase 2, putative 0.0021 0.0022 0.0022
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0058 0.0095 0.1371
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0036 0.0051 0.0041
Schistosoma mansoni immunophilin 0.0053 0.0085 0.0085
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.001 0.0001 0.0001
Brugia malayi AMP-binding enzyme family protein 0.0058 0.0095 0.0094
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.033 0.0628 0.0627
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0022 0.0025 0.0025
Trichomonas vaginalis guanylate cyclase, putative 0.001 0.0002 0.0001
Trichomonas vaginalis AGC family protein kinase 0.0013 0.0007 0.0006
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0061 0.0102 0.0101
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.001 0.0002 0.0001
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0058 0.0095 0.0095
Giardia lamblia TCP-1 chaperonin subunit beta 0.0025 0.003 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.3028 0.5908 0.5908
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0058 0.0095 0.2362
Brugia malayi Egg laying defective protein 4 0.0015 0.0011 0.001
Loa Loa (eye worm) FKBP5 protein 0.0061 0.0102 0.0101
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.014 0.0255 0.3961
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1716 0.3341 0.3341
Brugia malayi p70 ribosomal S6 kinase beta 0.0031 0.0043 0.0042
Trichomonas vaginalis guanylate cyclase, putative 0.001 0.0002 0.0001
Echinococcus granulosus guanine nucleotide binding protein G protein 0.001 0.0001 0.0001
Trichomonas vaginalis adenylate cyclase, putative 0.001 0.0002 0.0001
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0088 0.0155 0.0154
Loa Loa (eye worm) hypothetical protein 0.0022 0.0025 0.0024
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0864 0.1673 0.1672
Plasmodium falciparum phosphatidylinositol 3-kinase 0.033 0.0628 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.014 0.0255 0.3961
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.023 0.0432 0.0432
Echinococcus granulosus nervana 2 0.0021 0.0022 0.0022
Trichomonas vaginalis AGC family protein kinase 0.0011 0.0003 0.0002
Schistosoma mansoni inositol monophosphatase 0.0042 0.0064 0.0064
Loa Loa (eye worm) RNA binding protein 0.0089 0.0155 0.0154
Loa Loa (eye worm) PHD-finger family protein 0.0024 0.0028 0.0027
Schistosoma mansoni serine/threonine protein kinase 0.0015 0.0011 0.0011
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0036 0.0051 0.066
Trypanosoma brucei ISWI complex protein 0.0017 0.0016 0.0014
Leishmania major phosphatidylinositol 4-kinase, putative 0.033 0.0628 0.0618
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0031 0.0043 0.0042
Schistosoma mansoni camp-dependent protein kinase type II-alpha regulatory subunit 0.0015 0.0011 0.0011
Trichomonas vaginalis guanylate cyclase, putative 0.001 0.0002 0.0001
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0058 0.0095 0.2362
Echinococcus multilocularis hyperpolarization activated cyclic 0.0022 0.0025 0.0025
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0022 0.0025 0.0025
Trichomonas vaginalis guanylate cyclase, putative 0.001 0.0002 0.0001
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0968 0.1876 0.1875
Plasmodium falciparum T-complex protein 1 subunit beta 0.0025 0.003 0.0312
Entamoeba histolytica protein kinase, putative 0.0011 0.0003 0.0002
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0011 0.0003 0.0003
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0061 0.0102 0.0091
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0026 0.0024
Loa Loa (eye worm) hypothetical protein 0.0153 0.028 0.0279
Brugia malayi T-complex protein 1, beta subunit 0.0025 0.003 0.0029
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0011 0.0003 0.0002
Mycobacterium leprae Conserved hypothetical protein 0.0015 0.0011 0.0142
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.2421 0.4719 0.4718
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0002 0.0001
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0198 0.0369 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0968 0.1876 0.1876
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0033 0.0045 0.0045
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.001 0.0002 0.0001
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0748 0.1446 0.1446
Trichomonas vaginalis PIKK family atypical protein kinase 0.2764 0.5391 0.5391
Loa Loa (eye worm) phosphatidylinositol 3 0.033 0.0628 0.0627
Trichomonas vaginalis adenylate cyclase type vIII, putative 0.001 0.0002 0.0001
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.033 0.0628 0.0627
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0015 0.0011 0.0011
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0058 0.0095 0.2362
Entamoeba histolytica protein kinase rad3, putative 0.0968 0.1876 0.1876
Echinococcus multilocularis geminin 0.0632 0.1219 0.1219
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0002 0.0002
Schistosoma mansoni cpg binding protein 0.002 0.002 0.002
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0124 0.0225 0.0225
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0036 0.0051 0.0041
Schistosoma mansoni voltage-gated potassium channel 0.0018 0.0016 0.0016
Toxoplasma gondii propionate-CoA ligase 0.0058 0.0095 0.0114
Brugia malayi AMP-binding enzyme family protein 0.0198 0.0369 0.0368
Leishmania major phosphatidylinositol kinase, putative 0.033 0.0628 0.0618
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.023 0.0432 0.0432
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.033 0.0628 0.0627
Schistosoma mansoni hypothetical protein 0.0632 0.1219 0.1219
Echinococcus granulosus microtubule associated protein 2 0.2994 0.5843 0.5843
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0015 0.0011 0.0011
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.001 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.3807 0.7433 0.7433
Trichomonas vaginalis guanylate cyclase, putative 0.001 0.0002 0.0001
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0058 0.0095 0.1371
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0011 0.0003 0.0003
Echinococcus multilocularis Zinc finger, PHD finger 0.033 0.0628 0.0628
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0061 0.0102 0.0101
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0022 0.0025 0.0024
Leishmania major phosphatidylinositol kinase related protein, putative 0.033 0.0628 0.0618
Trypanosoma brucei target of rapamycin kinase 3, putative 0.4075 0.7958 0.7958
Trichomonas vaginalis adenylate cyclase, putative 0.001 0.0002 0.0001
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0031 0.003
Brugia malayi AMP-binding enzyme family protein 0.0058 0.0095 0.0094
Brugia malayi hypothetical protein 0.0082 0.0142 0.0142
Entamoeba histolytica hypothetical protein 0.0968 0.1876 0.1876
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0058 0.0095 0.1371
Echinococcus granulosus tar DNA binding protein 0.0089 0.0155 0.0155
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0025 0.003 0.003
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0023 0.0026 0.0016
Trichomonas vaginalis guanylate cyclase, putative 0.001 0.0002 0.0001
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.5118 1 1
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0015 0.0011 0.0008
Treponema pallidum exodeoxyribonuclease (exoA) 0.0036 0.0051 0.4474
Echinococcus granulosus guanine nucleotide binding protein G protein 0.001 0.0001 0.0001
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.033 0.0628 1
Echinococcus multilocularis expressed conserved protein 0.0015 0.0011 0.0011
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.033 0.0628 0.0627
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0069 0.0117 0.0117
Echinococcus multilocularis snurportin 1 0.0331 0.063 0.063
Trichomonas vaginalis PIKK family atypical protein kinase 0.033 0.0628 0.0627
Trichomonas vaginalis guanylate cyclase, putative 0.001 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0144 0.0263 0.0262
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.001 0.0002 0.0001
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0061 0.0102 0.0091
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.033 0.0628 0.0627
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0064 0.0062
Echinococcus granulosus cGMP dependent protein kinase 1 0.0015 0.0011 0.0011
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0058 0.0095 0.0093
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.001 0.0002 0.0001
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.033 0.0628 0.0618
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0025 0.003 0.003
Schistosoma mansoni zinc finger protein 0.0023 0.0027 0.0027
Trypanosoma cruzi target of rapamycin kinase 3 0.4075 0.7958 0.7956
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0061 0.0102 0.0101
Schistosoma mansoni phosphatidylinositol 4-kinase 0.033 0.0628 0.0628
Echinococcus multilocularis serine:threonine protein kinase N2 0.0011 0.0003 0.0003
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0036 0.0051 0.0051
Echinococcus multilocularis L aminoadipate semialdehyde 0.0095 0.0167 0.0167
Echinococcus multilocularis cAMP dependent protein kinase regulatory 0.0015 0.0011 0.0011
Toxoplasma gondii FATC domain-containing protein 0.0968 0.1876 0.2514
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0025 0.003 0.0312
Entamoeba histolytica hypothetical protein 0.033 0.0628 0.0627
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.5118 1 1
Entamoeba histolytica protein kinase, putative 0.0034 0.0047 0.0046
Loa Loa (eye worm) phosphatidylinositol 3 0.033 0.0628 0.0627
Onchocerca volvulus 0.0095 0.0167 0.0874
Onchocerca volvulus 0.0058 0.0095 0.0495
Onchocerca volvulus 0.0088 0.0155 0.0807
Schistosoma mansoni cyclic nucleotide-gated ion channel 0.0015 0.0011 0.0011
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0198 0.0369 0.5803
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0124 0.0225 0.0225
Onchocerca volvulus 0.0124 0.0225 0.1175
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0042 0.0064 0.1493
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0113 0.0202 0.0201
Trichomonas vaginalis guanylate cyclase beta 2 subunit, putative 0.001 0.0002 0.0001
Brugia malayi RNA recognition motif domain containing protein 0.0089 0.0155 0.0154
Entamoeba histolytica hypothetical protein 0.033 0.0628 0.0627
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0058 0.0095 0.1371
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.023 0.0432 0.0432
Schistosoma mansoni hypothetical protein 0.033 0.0628 0.0628
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0022 0.0025 0.0024
Schistosoma mansoni hypothetical protein 0.001 0.0002 0.0002
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1716 0.3341 0.3334
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0047 0.0046
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.033 0.0628 0.0628
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0025 0.003 0.003
Mycobacterium ulcerans acyl-CoA synthetase 0.0058 0.0095 0.2362
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.033 0.0628 0.0628
Loa Loa (eye worm) hypothetical protein 0.0153 0.028 0.0279
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0022 0.0025 0.0025
Plasmodium vivax acyl-CoA synthetase, putative 0.0148 0.0271 0.4217
Trichomonas vaginalis PIKK family atypical protein kinase 0.5118 1 1
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0058 0.0095 0.0085
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.033 0.0628 0.0627
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1716 0.3341 0.3334
Echinococcus granulosus serine/threonine protein kinase 0.0023 0.0026 0.0026
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0015 0.0011 0.0011
Leishmania major hypothetical protein, conserved 0.033 0.0628 0.0618
Trichomonas vaginalis PIKK family atypical protein kinase 0.0968 0.1876 0.1876
Mycobacterium leprae conserved hypothetical protein 0.033 0.0628 1
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0031 0.003
Trichomonas vaginalis hypothetical protein 0.001 0.0002 0.0001
Echinococcus multilocularis serine:threonine protein kinase N2 0.0011 0.0003 0.0003
Trichomonas vaginalis adenylate cyclase, putative 0.001 0.0002 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0748 0.1446 0.1446
Loa Loa (eye worm) hypothetical protein 0.0148 0.0271 0.027
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.001 0.0001 0.0001
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0058 0.0095 0.0094
Schistosoma mansoni trimeric G-protein alpha o subunit 0.001 0.0001 0.0001
Trichomonas vaginalis adenylate cyclase, putative 0.001 0.0002 0.0001
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0042 0.0064 1
Loa Loa (eye worm) hypothetical protein 0.0638 0.123 0.1229
Plasmodium falciparum phosphatidylinositol 4-kinase 0.033 0.0628 1
Loa Loa (eye worm) AGC/PKG protein kinase 0.0015 0.0011 0.001
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0058 0.0095 0.0085
Trichomonas vaginalis adenylate cyclase, putative 0.001 0.0002 0.0001
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0042 0.0064 0.0072
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0148 0.0271 1
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0021 0.0022 0.0022
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.033 0.0628 0.0627
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0026 0.0016
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0027 0.0034 0.0891
Echinococcus granulosus single minded 2 0.001 0.0002 0.0002
Schistosoma mansoni tar DNA-binding protein 0.0089 0.0155 0.0155
Leishmania major phosphopantetheinyl transferase-like protein 0.0027 0.0034 0.0023
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.033 0.0628 0.0628
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.5118 1 1
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0058 0.0095 0.0095
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0144 0.0263 0.0263
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1716 0.3341 0.3334
Plasmodium vivax importin-beta 2, putative 0.0031 0.0042 0.0513
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.033 0.0628 0.0627
Trichomonas vaginalis guanylate cyclase, putative 0.001 0.0002 0.0001
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0064 0.0063
Schistosoma mansoni serine/threonine kinase 0.0011 0.0003 0.0003
Schistosoma mansoni immunophilin 0.0061 0.0102 0.0102
Echinococcus multilocularis nervana 2 0.0021 0.0022 0.0022
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0036 0.0051 0.066
Trichomonas vaginalis guanylate cyclase, putative 0.001 0.0002 0.0001
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.001 0.0002 0.0001
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0022 0.0025 0.0024
Leishmania major hypothetical protein, conserved 0.0017 0.0016 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.4071 0.795 0.795
Brugia malayi Protein kinase domain containing protein 0.0034 0.0047 0.0046
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0058 0.0095 0.2362
Entamoeba histolytica hypothetical protein 0.033 0.0628 0.0627
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0198 0.0369 1
Trichomonas vaginalis adenylate cyclase, putative 0.001 0.0002 0.0001
Schistosoma mansoni hypothetical protein 0.0331 0.063 0.063
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0058 0.0095 0.0093
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.033 0.0628 1
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.0015 0.0011 0.0011
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.001 0.0001 0.0001
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.5118 1 1
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0058 0.0095 0.1493
Loa Loa (eye worm) hypothetical protein 0.0198 0.0369 0.0368
Mycobacterium ulcerans acyl-CoA synthetase 0.0058 0.0095 0.2362
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0026 0.0026
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.001 0.0001 0.0001
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0036 0.0051 0.0051
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0021 0.0022 0.0191
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.033 0.0628 0.0628
Onchocerca volvulus 0.0058 0.0095 0.0495
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.033 0.0628 0.0627
Trichomonas vaginalis ran, putative 0.0023 0.0026 0.0025
Loa Loa (eye worm) hypothetical protein 0.0053 0.0085 0.0084
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0034 0.0034
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0198 0.0369 0.5803
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.033 0.0628 0.0618
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.033 0.0628 0.0832
Schistosoma mansoni voltage-gated potassium channel 0.0123 0.0222 0.0222
Echinococcus multilocularis rac serine:threonine kinase 0.0023 0.0026 0.0026
Brugia malayi RNA, U transporter 1 0.0088 0.0154 0.0153
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0041 0.0062 0.0062
Schistosoma mansoni serine/threonine protein kinase 0.0011 0.0003 0.0003
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.033 0.0628 0.0627
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0002 0.0002
Loa Loa (eye worm) bromodomain containing protein 0.002 0.0021 0.002
Trichomonas vaginalis AGC family protein kinase 0.0011 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0198 0.0369 0.0368
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.001 0.0001 0.0001
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.023 0.0432 0.0431
Schistosoma mansoni serine/threonine-protein kinase 0.0023 0.0026 0.0026
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.001 0.0001 0.0001
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0148 0.0271 0.4217
Entamoeba histolytica protein kinase, putative 0.0031 0.0043 0.0042
Loa Loa (eye worm) hypothetical protein 0.0058 0.0095 0.0094
Loa Loa (eye worm) AGC/NDR protein kinase 0.0011 0.0003 0.0002
Schistosoma mansoni voltage-gated potassium channel 0.0123 0.0222 0.0222
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0061 0.0102 0.0102
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.002 0.002
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0021 0.0022 0.0022
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0331 0.063 0.0629
Brugia malayi Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative 0.0015 0.0011 0.001
Brugia malayi Importin beta-1 subunit 0.0031 0.0042 0.0041
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.023 0.0432 0.0432
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.5118 1 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0119 0.0215 0.0215
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.033 0.0628 0.0628
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0058 0.0095 0.0085
Trichomonas vaginalis PIKK family atypical protein kinase 0.3058 0.5968 0.5968
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0015 0.0011 0.0011
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.002 0.002
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0058 0.0095 0.0094
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0061 0.0102 0.0091
Plasmodium falciparum importin beta, putative 0.0031 0.0042 0.0513
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.5118 1 1
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0002 0.0001
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0026 0.0021
Brugia malayi exodeoxyribonuclease III family protein 0.0036 0.0051 0.0051
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.033 0.0628 1
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0002 0.0001
Schistosoma mansoni GTP-binding protein alpha subunit 0.001 0.0001 0.0001
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0113 0.0202 0.0202
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0058 0.0095 0.0114
Echinococcus multilocularis voltage gated potassium channel 0.0033 0.0045 0.0045
Trichomonas vaginalis adenylate cyclase type IX, putative 0.001 0.0002 0.0001
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.001 0.0001 0.0001
Entamoeba histolytica acyl-CoA synthetase, putative 0.0198 0.0369 0.0368
Brugia malayi Bromodomain containing protein 0.0087 0.0151 0.0151
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.033 0.0628 0.0628
Trichomonas vaginalis guanylate cyclase beta 1 subunit, putative 0.001 0.0002 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.4071 0.795 0.795
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.033 0.0628 0.0628
Toxoplasma gondii t-complex protein beta subunit 0.0025 0.003 0.0026
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0026 0.0253
Echinococcus granulosus survival motor neuron protein 1 0.0434 0.083 0.083
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0034 0.0034
Entamoeba histolytica hypothetical protein 0.0027 0.0034 0.0033
Trichomonas vaginalis guanylate cyclase, putative 0.001 0.0002 0.0001
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0061 0.0102 0.0091
Entamoeba histolytica protein kinase, putative 0.0034 0.0047 0.0046
Schistosoma mansoni ap endonuclease 0.0036 0.0051 0.0051
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.033 0.0628 0.0626
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.001 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.005 0.0079 0.0078
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0058 0.0095 0.2362
Echinococcus multilocularis serine protein kinase ATM 0.0968 0.1876 0.1876
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0022 0.0025 0.0025
Trichomonas vaginalis guanylate cyclase, putative 0.001 0.0002 0.0001
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0061 0.0102 0.2544
Schistosoma mansoni 60S ribosomal protein L21 0.0018 0.0016 0.0016
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.001 0.0001 0.0001
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0047 0.0073 0.0073
Echinococcus multilocularis 0.033 0.0628 0.0628
Echinococcus granulosus serine threonine protein kinase nrc 0.0021 0.0022 0.0022
Onchocerca volvulus 0.0015 0.0011 0.0051
Echinococcus multilocularis protein kinase c epsilon type 0.0011 0.0003 0.0003
Entamoeba histolytica hypothetical protein 0.033 0.0628 0.0627
Brugia malayi F/Y-rich N-terminus family protein 0.0013 0.0006 0.0006
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0061 0.0102 0.1476
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.033 0.0628 0.0628
Schistosoma mansoni transcription factor LCR-F1 0.0082 0.0142 0.0142
Schistosoma mansoni importin beta-1 0.0031 0.0042 0.0042
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0025 0.003 0.003
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0061 0.0102 0.0101
Trichomonas vaginalis adenylate cyclase type IX, putative 0.001 0.0002 0.0001
Leishmania major acetyl-CoA synthetase, putative 0.0058 0.0095 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.0638 0.123 0.1229
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0002 0.0001
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.023 0.0432 0.0431
Echinococcus granulosus geminin 0.0632 0.1219 0.1219
Echinococcus granulosus Glutaredoxin protein 5 0.0021 0.0022 0.0022
Schistosoma mansoni serine/threonine protein kinase 0.0015 0.0011 0.0011
Schistosoma mansoni hypothetical protein 0.0015 0.0011 0.0011
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.5118 1 1
Schistosoma mansoni hypothetical protein 0.0017 0.0016 0.0016
Leishmania major fk506-binding protein 1-like protein 0.0061 0.0102 0.0091
Toxoplasma gondii target of rapamycin (TOR), putative 0.3807 0.7433 1
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0011 0.0003 0.0002
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0033 0.0045 0.0045
Trichomonas vaginalis ap endonuclease, putative 0.0036 0.0051 0.0051
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0082 0.0142 0.0142
Toxoplasma gondii AGC kinase 0.0031 0.0043 0.0044
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0124 0.0225 0.0225
Leishmania major phosphatidylinositol 3-kinase, putative 0.033 0.0628 0.0618
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0027 0.0034 0.0376
Echinococcus granulosus zinc finger protein 0.0023 0.0027 0.0027
Brugia malayi AMP-binding enzyme family protein 0.0198 0.0369 0.0368
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.014 0.0255 0.3961
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0026 0.0026
Mycobacterium tuberculosis Conserved hypothetical protein 0.033 0.0628 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0041 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0148 0.0271 0.027
Echinococcus granulosus hyperpolarization activated cyclic 0.0022 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0047 0.0073 0.0072
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0082 0.0142 0.0142
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0002 0.0001
Echinococcus granulosus guanine nucleotide binding protein subunit 0.001 0.0001 0.0001
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0061 0.0102 0.01
Echinococcus multilocularis dnaJ subfamily B 0.0283 0.0535 0.0535
Trichomonas vaginalis adenylate cyclase type III, putative 0.001 0.0002 0.0001
Giardia lamblia Kinase, AGC PKA 0.0021 0.0022 0.0012
Loa Loa (eye worm) hypothetical protein 0.1079 0.2093 0.2092
Trichomonas vaginalis adenylate cyclase type, putative 0.001 0.0002 0.0001
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0022 0.0025 0.0025
Mycobacterium ulcerans acyl-CoA synthetase 0.0058 0.0095 0.2362
Echinococcus multilocularis expressed protein 0.001 0.0001 0.0001
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0026 0.0016
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0038 0.0055 0.0858
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0015 0.0011 0.0001
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.033 0.0628 0.0627
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0011 0.0003 0.0003
Leishmania major T-complex protein 1, beta subunit, putative 0.0025 0.003 0.0019
Trypanosoma brucei cAMP binding protein, putative 0.0015 0.0011 0.0008
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0025 0.003 0.003
Schistosoma mansoni tar DNA-binding protein 0.0089 0.0155 0.0155
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0968 0.1876 0.1868
Trichomonas vaginalis PIKK family atypical protein kinase 0.1716 0.3341 0.3341
Brugia malayi Protein kinase domain containing protein 0.0011 0.0003 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.2764 0.5391 0.5391
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0015 0.0011 0.0011
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.033 0.0628 0.0618
Leishmania major hypothetical protein, unknown function 0.033 0.0628 0.0618
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0113 0.0202 0.0201
Echinococcus multilocularis microtubule associated protein 2 0.2994 0.5843 0.5843
Brugia malayi AMP-binding enzyme family protein 0.0058 0.0095 0.0094
Trichomonas vaginalis adenylate cyclase type VI, putative 0.001 0.0002 0.0001
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0058 0.0095 0.0085
Trichomonas vaginalis antibiotic synthetase, putative 0.0058 0.0095 0.0094
Echinococcus granulosus protein kinase c epsilon type 0.0011 0.0003 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.3807 0.7433 0.7433
Echinococcus multilocularis serine:threonine protein kinase 38 0.0011 0.0003 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0638 0.123 0.1229
Entamoeba histolytica PH domain containing protein kinase, putative 0.0023 0.0026 0.0026
Schistosoma mansoni zinc finger protein 0.0017 0.0016 0.0016
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1079 0.2093 0.2805
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0015 0.0011 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.3807 0.7433 0.7433
Schistosoma mansoni microtubule-associated protein tau 0.2994 0.5843 0.5843
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0748 0.1446 0.1446
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.001 0.0001 0.0001
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.033 0.0628 0.0627
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0061 0.0102 0.01
Trichomonas vaginalis PIKK family atypical protein kinase 0.4071 0.795 0.795
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.033 0.0628 0.0626
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.001 0.0001 0.0001
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0042 0.0042
Toxoplasma gondii exonuclease III APE 0.0036 0.0051 0.0055
Mycobacterium ulcerans acetyl-CoA synthetase 0.0058 0.0095 0.2362
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.033 0.0628 0.0628
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0015 0.0011 0.0011
Trichomonas vaginalis fk506-binding protein, putative 0.0061 0.0102 0.0101
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.033 0.0628 0.0618
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.033 0.0628 0.0618
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0025 0.0025
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0047 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.437 0.8535 0.8535
Trichomonas vaginalis guanylate cyclase, putative 0.001 0.0002 0.0001
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.033 0.0628 0.0627
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0011 0.0003 0.0003
Trypanosoma brucei rac serine-threonine kinase, putative 0.0034 0.0047 0.0045
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.002 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.033 0.0628 0.0627
Brugia malayi RNA binding protein 0.0089 0.0155 0.0154
Trypanosoma brucei protein kinase A regulatory subunit 0.0015 0.0011 0.0008
Brugia malayi hypothetical protein 0.0434 0.083 0.083
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0058 0.0095 0.0094
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.0015 0.0011 0.0011
Schistosoma mansoni tar DNA-binding protein 0.0089 0.0155 0.0155
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.014 0.0255 0.3961
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0144 0.0263 0.0263
Loa Loa (eye worm) hypothetical protein 0.1043 0.2023 0.2022
Trypanosoma brucei Flagellar Member 6 0.0015 0.0011 0.0008
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0124 0.0225 0.0289
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0061 0.0102 0.0101
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.001 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0148 0.0271 0.027
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.033 0.0628 0.0628
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0064 0.0063
Trypanosoma cruzi Protein kinase B 0.0023 0.0026 0.0016
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0047 0.0046
Mycobacterium ulcerans hypothetical protein 0.0198 0.0369 1
Loa Loa (eye worm) hypothetical protein 0.0748 0.1446 0.1446
Trichomonas vaginalis PIKK family atypical protein kinase 0.1373 0.2669 0.2669
Echinococcus multilocularis survival motor neuron protein 1 0.0434 0.083 0.083
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0968 0.1876 0.1868
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0025 0.003 0.0029
Loa Loa (eye worm) phosphatidylinositol 3 0.5118 1 1
Schistosoma mansoni hypothetical protein 0.0024 0.0028 0.0028
Schistosoma mansoni immunophilin 0.0061 0.0102 0.0102
Trichomonas vaginalis intestinal guanylate cyclase, putative 0.001 0.0002 0.0001
Trichomonas vaginalis adenylate cyclase, putative 0.001 0.0002 0.0001
Trichomonas vaginalis adenylyl cyclase type V, putative 0.001 0.0002 0.0001
Echinococcus granulosus serine protein kinase ATM 0.0968 0.1876 0.1876
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1716 0.3341 0.3341
Trichomonas vaginalis adenylate cyclase, putative 0.001 0.0002 0.0001
Echinococcus granulosus histone lysine methyltransferase setb 0.0144 0.0263 0.0263
Trichomonas vaginalis adenylate cyclase, putative 0.001 0.0002 0.0001
Giardia lamblia Phosphatidylinositol 4-kinase 0.033 0.0628 0.0618
Brugia malayi Pre-SET motif family protein 0.0124 0.0225 0.0224
Plasmodium vivax acetyl-CoA synthetase, putative 0.0058 0.0095 0.1371
Echinococcus multilocularis serine threonine protein kinase 0.0011 0.0003 0.0003
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.033 0.0628 0.0627
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.033 0.0628 0.0618
Onchocerca volvulus 0.0015 0.0011 0.0051
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.033 0.0628 0.0627
Trichomonas vaginalis guanylate cyclase, putative 0.001 0.0002 0.0001
Trichomonas vaginalis adenylate cyclase type IX, putative 0.001 0.0002 0.0001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.023 0.0432 0.0432
Echinococcus multilocularis patatin phospholipase domain containing protein 0.0015 0.0011 0.0011
Brugia malayi AMP-binding enzyme family protein 0.0198 0.0369 0.0368
Schistosoma mansoni inositol monophosphatase 0.0042 0.0064 0.0064
Echinococcus granulosus muscleblind protein 0.0153 0.028 0.028
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1716 0.3341 0.334
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0021 0.0022 0.0022
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0036 0.0051 0.0041
Schistosoma mansoni voltage-gated potassium channel 0.0033 0.0045 0.0045
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0058 0.0095 0.0094
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0089 0.0155 0.0154
Schistosoma mansoni serine/threonine protein kinase 0.0011 0.0003 0.0003
Trypanosoma brucei hypothetical protein, conserved 0.0027 0.0034 0.0032
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1716 0.3341 0.3341
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.023 0.0432 0.0432
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0058 0.0095 0.1371
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0027 0.0034 0.0647
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0027 0.0034 0.0376
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.033 0.0628 0.0618
Trichomonas vaginalis PIKK family atypical protein kinase 0.3028 0.5908 0.5908
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.033 0.0628 0.0628
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0011 0.0002 0.0001
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.033 0.0628 0.0627
Loa Loa (eye worm) hypothetical protein 0.0033 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0434 0.083 0.083
Schistosoma mansoni hypothetical protein 0.0283 0.0535 0.0535
Brugia malayi Pre-SET motif family protein 0.0864 0.1673 0.1672
Schistosoma mansoni serine/threonine protein kinase 0.0011 0.0003 0.0003
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0061 0.0102 0.0102
Trichomonas vaginalis PIKK family atypical protein kinase 0.3058 0.5968 0.5968
Trichomonas vaginalis adenylate cyclase type IX, putative 0.001 0.0002 0.0001
Leishmania major peptidylprolyl isomerase-like protein 0.0061 0.0102 0.0091
Entamoeba histolytica hypothetical protein 0.0082 0.0142 0.0142
Loa Loa (eye worm) hypothetical protein 0.0044 0.0067 0.0066
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.033 0.0628 0.0618
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0058 0.0095 0.0094
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0198 0.0369 0.5862
Trichomonas vaginalis cAMP-dependent protein kinase regulatory subunit, putative 0.0015 0.0011 0.001
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0638 0.123 0.1221
Trichomonas vaginalis guanylate cyclase, putative 0.001 0.0002 0.0001
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.001 0.0002 0.0001
Plasmodium falciparum cGMP-dependent protein kinase 0.0015 0.0011 0.0007
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0968 0.1876 0.1876
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0105 0.0187 0.0187
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.023 0.0432 0.0432
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.033 0.0628 0.0627
Trichomonas vaginalis PIKK family atypical protein kinase 0.5118 1 1
Schistosoma mansoni hypothetical protein 0.0082 0.0142 0.0142
Schistosoma mansoni GTP-binding protein alpha subunit 0.001 0.0001 0.0001
Loa Loa (eye worm) AGC/AKT protein kinase 0.0034 0.0047 0.0046
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0058 0.0095 0.1371
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0021 0.0022 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.3807 0.7433 0.7433
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0002 0.0001
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0022 0.0025 0.0025
Loa Loa (eye worm) phosphatidylinositol kinase 0.033 0.0628 0.0627
Brugia malayi cAMP-dependent protein kinase regulatory chain, putative 0.0015 0.0011 0.001
Trichomonas vaginalis adenylate cyclase type III, putative 0.001 0.0002 0.0001
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0198 0.0369 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0198 0.0369 0.0359
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0031 0.002
Echinococcus multilocularis cAMP dependent protein kinase type I beta 0.0015 0.0011 0.0011
Brugia malayi Protein kinase domain containing protein 0.0011 0.0003 0.0002
Onchocerca volvulus 0.033 0.0628 0.329
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0069 0.0117 0.0117
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0061 0.0102 0.0091
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0047 0.0046
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0053 0.0085 0.0085
Onchocerca volvulus 0.0058 0.0095 0.0495
Loa Loa (eye worm) hypothetical protein 0.0095 0.0167 0.0167
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0079 0.1115
Toxoplasma gondii histone lysine methyltransferase SET1 0.0045 0.0069 0.0079
Leishmania major 4-coumarate:coa ligase-like protein 0.0198 0.0369 0.0359
Trichomonas vaginalis guanylate cyclase, putative 0.001 0.0002 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.5118 1 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0036 0.0051 0.5804
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0042 0.0064 0.0063
Echinococcus granulosus serine:threonine protein kinase N2 0.0011 0.0003 0.0003
Echinococcus granulosus inositol monophosphatase 1 0.0042 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0081 0.014 0.0139
Brugia malayi FAT domain containing protein 0.0748 0.1446 0.1446
Trichomonas vaginalis set domain proteins, putative 0.0984 0.1907 0.1906
Echinococcus multilocularis hyperpolarization activated cyclic 0.0022 0.0025 0.0025
Echinococcus granulosus voltage gated potassium channel 0.0033 0.0045 0.0045
Echinococcus multilocularis protein kinase c iota type 0.0011 0.0003 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0002 0.0001
Loa Loa (eye worm) AGC/PKN protein kinase 0.0011 0.0003 0.0002
Brugia malayi TAR-binding protein 0.0089 0.0155 0.0154
Entamoeba histolytica acyl-CoA synthetase, putative 0.0198 0.0369 0.0368
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0002 0.0001
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0036 0.0051 0.0041
Trichomonas vaginalis antibiotic synthetase, putative 0.0058 0.0095 0.0094
Trichomonas vaginalis PIKK family atypical protein kinase 0.2764 0.5391 0.5391
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.001
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0027 0.0034 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.3058 0.5968 0.5968
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0025 0.003 0.0019
Schistosoma mansoni tar DNA-binding protein 0.0089 0.0155 0.0155
Trichomonas vaginalis adenylate cyclase type, putative 0.001 0.0002 0.0001
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0015 0.0011 0.0001
Trichomonas vaginalis adenylate cyclase, putative 0.001 0.0002 0.0001
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.033 0.0628 0.0627
Trichomonas vaginalis PIKK family atypical protein kinase 0.276 0.5383 0.5383
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.0015 0.0011 0.0011
Brugia malayi Hr1 repeat family protein 0.0011 0.0003 0.0002
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0064 0.0054
Schistosoma mansoni hypothetical protein 0.0748 0.1446 0.1446
Trichomonas vaginalis adenylate cyclase, putative 0.001 0.0002 0.0001
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.033 0.0628 0.0628
Echinococcus multilocularis zinc finger protein 0.0023 0.0027 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.1716 0.3341 0.3341
Giardia lamblia GTOR 0.5118 1 1
Schistosoma mansoni survival motor neuron protein 0.0088 0.0155 0.0155
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0061 0.0102 0.0101
Trichomonas vaginalis ap endonuclease, putative 0.0036 0.0051 0.0051
Brugia malayi N-terminal motif family protein 0.0015 0.0011 0.001
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0058 0.0095 0.1493
Schistosoma mansoni cpg binding protein 0.0023 0.0027 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.276 0.5383 0.5383
Leishmania major 4-coumarate:coa ligase-like protein 0.0198 0.0369 0.0359
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.001 0.0001 0.0001
Trichomonas vaginalis adenylate cyclase, putative 0.001 0.0002 0.0001
Trichomonas vaginalis cAMP-dependent protein kinase type I-beta regulatory subunit, putative 0.0015 0.0011 0.001
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0058 0.0095 0.0114
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.033 0.0628 0.0628
Echinococcus granulosus protein kinase C gamma type 0.0011 0.0003 0.0003
Trypanosoma cruzi ISWI complex protein 0.0017 0.0016 0.0005
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0064 0.0054
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0011 0.0003 0.0003
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0105 0.0187 0.0187
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0015 0.0011 0.0011
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0036 0.0051 0.0051
Mycobacterium ulcerans acyl-CoA synthetase 0.0058 0.0095 0.2362
Loa Loa (eye worm) CXXC zinc finger family protein 0.002 0.002 0.002
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0144 0.0263 0.0263
Schistosoma mansoni phosphatidylinositol 4-kinase 0.033 0.0628 0.0628
Brugia malayi Bromodomain containing protein 0.0044 0.0067 0.0066
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.5118 1 1
Trichomonas vaginalis adenylate cyclase type, putative 0.001 0.0002 0.0001
Entamoeba histolytica hypothetical protein 0.0082 0.0142 0.0142
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0061 0.0102 0.0091
Mycobacterium ulcerans acyl-CoA synthetase 0.0058 0.0095 0.2362
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0027 0.0034 0.0031
Loa Loa (eye worm) oxidoreductase 0.0058 0.0095 0.0094
Plasmodium vivax SET domain protein, putative 0.0124 0.0225 0.3471
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.033 0.0628 0.0628
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0022 0.0025 0.0025
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0061 0.0102 0.1476
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0011 0.0003 0.0002
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0022 0.0025 0.0025
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.033 0.0628 0.0618
Schistosoma mansoni ap endonuclease 0.0036 0.0051 0.0051
Brugia malayi Cyclic-nucleotide gated cation channel 0.0022 0.0025 0.0024
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.033 0.0628 0.0628
Echinococcus multilocularis tar DNA binding protein 0.0089 0.0155 0.0155
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0058 0.0095 0.1371
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0025 0.003 0.0028
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0002
Schistosoma mansoni camp-dependent protein kinase type II regulatory subunit 0.0015 0.0011 0.0011

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 5 nM Concentration required to inhibit the entry of HIV-1 reporter virus (ADA) into U-87 cells by 50% ChEMBL. 12086500
IC50 (functional) = 5 nM Concentration required to inhibit the entry of HIV-1 reporter virus (ADA) into U-87 cells by 50% ChEMBL. 12086500
Ki (binding) = 55 nM Inhibition of RANTES binding to Chemokine receptor type 5 receptor from NIH 3T3 cells ChEMBL. 12086500
Ki (binding) = 55 nM Inhibition of RANTES binding to the human C-C chemokine receptor type 5 (CCR5) ChEMBL. 14521412
Ki (binding) = 55 nM Inhibition of RANTES binding to Chemokine receptor type 5 receptor from NIH 3T3 cells ChEMBL. 12086500
Ki (binding) = 55 nM Inhibition of RANTES binding to the human C-C chemokine receptor type 5 (CCR5) ChEMBL. 14521412

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 12086500

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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