Detailed information for compound 1772589

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 389.452 | Formula: C16H15N5O3S2
  • H donors: 0 H acceptors: 5 LogP: 1.74 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)n1c(S)nnc1c1csc(n1)N(C(=O)C)C(=O)C
  • InChi: 1S/C16H15N5O3S2/c1-9(22)20(10(2)23)16-17-13(8-26-16)14-18-19-15(25)21(14)11-4-6-12(24-3)7-5-11/h4-8H,1-3H3,(H,19,25)
  • InChiKey: ZQUCRTOPWQUGSQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bos taurus Dihydrofolate reductase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi dihydrofolate reductase family protein Get druggable targets OG5_128410 All targets in OG5_128410
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) Get druggable targets OG5_128410 All targets in OG5_128410
Echinococcus granulosus dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Mycobacterium ulcerans dihydrofolate reductase DfrA Get druggable targets OG5_128410 All targets in OG5_128410
Brugia malayi Dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) Get druggable targets OG5_128410 All targets in OG5_128410
Echinococcus multilocularis dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Chlamydia trachomatis dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Schistosoma mansoni dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Candida albicans dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Loa Loa (eye worm) dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Candida albicans dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Schistosoma japonicum ko:K00287 dihydrofolate reductase [EC1.5.1.3], putative Get druggable targets OG5_128410 All targets in OG5_128410
Candida albicans hypothetical protein Get druggable targets OG5_128410 All targets in OG5_128410
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Cryptosporidium hominis chain A, crystal structure of Dhfr Dihydrofolate reductase   187 aa 181 aa 33.1 %
Leishmania major dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 172 aa 34.9 %
Theileria parva dihydrofolate reductase-thymidylate synthase, putative Dihydrofolate reductase   187 aa 158 aa 35.4 %
Plasmodium knowlesi bifunctional dihydrofolate reductase-thymidylate synthase, putative Dihydrofolate reductase   187 aa 209 aa 30.1 %
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 186 aa 35.5 %
Leishmania braziliensis dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 172 aa 33.7 %
Cryptosporidium parvum dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 181 aa 32.6 %
Neospora caninum Bifunctional dihydrofolate reductase-thymidylate synthase, related Dihydrofolate reductase   187 aa 187 aa 34.8 %
Babesia bovis dihydrofolate reductase/thymidilate synthase Dihydrofolate reductase   187 aa 191 aa 31.9 %
Leishmania mexicana dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 172 aa 32.0 %
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative Dihydrofolate reductase   187 aa 209 aa 29.2 %
Leishmania infantum dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 172 aa 34.9 %
Plasmodium berghei bifunctional dihydrofolate reductase-thymidylate synthase, putative Dihydrofolate reductase   187 aa 211 aa 29.4 %
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 201 aa 30.3 %
Plasmodium yoelii thymidylate synthase, putative Dihydrofolate reductase   187 aa 211 aa 28.4 %
Leishmania donovani dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 172 aa 34.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0034 0.0022
Schistosoma mansoni sphingoid long chain base kinase 0.3395 1 1
Trichomonas vaginalis rotamase, putative 0.0032 0.0059 0.051
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0012 0.0012
Loa Loa (eye worm) glutaminase 2 0.0268 0.0756 0.0755
Entamoeba histolytica hypothetical protein 0.0071 0.0174 0.0174
Loa Loa (eye worm) hypothetical protein 0.0132 0.0356 0.0354
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0014 0.0003
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0022 0.003 0.0024
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0024 0.0034 0.0028
Trypanosoma brucei phosphoglycerate kinase 0.0061 0.0146 0.1645
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0069 0.0643
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0126 0.0119
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0044 0.0038
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0011 0.0005
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0057 0.0057
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0053 0.072
Trypanosoma brucei unspecified product 0.0036 0.0071 0.0743
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.0139 0.0133
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0053 0.0047
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0005
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0018 0.0019 0.0012
Plasmodium vivax JmjC domain containing protein 0.0016 0.0011 0.0003
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0075 0.0069
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0024 0.0034 0.0171
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0069 0.0058
Echinococcus granulosus dnaJ subfamily B 0.1213 0.3549 0.3545
Schistosoma mansoni apoferritin-2 0.0025 0.0039 0.0039
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0093 0.0241 0.282
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0048 0.0106 0.01
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.0159 0.0436 0.0429
Leishmania major phosphoglycerate kinase C, glycosomal 0.0167 0.0458 0.5402
Schistosoma mansoni hypothetical protein 0.0168 0.0461 0.0461
Loa Loa (eye worm) nuclear hormone receptor 0.0014 0.0007 0.0005
Echinococcus multilocularis dihydrofolate reductase 0.0208 0.0578 0.0572
Brugia malayi jmjC domain containing protein 0.0059 0.0139 0.1594
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.0059 0.0604
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0022 0.00000000030425
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0078 0.0195 0.2364
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.0159 0.0436 0.0429
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0053 0.0563
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0074 0.0705
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0295 0.0837 0.0836
Trypanosoma brucei DNA polymerase kappa, putative 0.0058 0.0138 0.1548
Echinococcus granulosus ferritin 0.0025 0.0039 0.0033
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0295 0.0837 1
Plasmodium falciparum T-complex protein 1 subunit beta 0.0024 0.0034 0.0751
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0079 0.0199 0.4356
Loa Loa (eye worm) hypothetical protein 0.003 0.0053 0.0052
Schistosoma mansoni cpg binding protein 0.0092 0.0236 0.0236
Echinococcus granulosus 6 phosphofructokinase 0.0107 0.0281 0.0274
Schistosoma mansoni rotamase 0.0033 0.0062 0.0062
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0095 0.1889
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0022 0.0031 0.0025
Leishmania major DNA polymerase eta, putative 0.0041 0.0086 0.0929
Chlamydia trachomatis phosphoglycerate kinase 0.0167 0.0458 0.7851
Echinococcus granulosus Diacylglycerol kinase zeta 0.0132 0.0356 0.0349
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0095 0.1002
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.0631 0.0621
Schistosoma mansoni zinc finger protein 0.0015 0.0009 0.0009
Trichomonas vaginalis DNA helicase recq1, putative 0.0044 0.0096 0.1011
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0069 0.017 0.0168
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0014 0.0008
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0156 0.1799
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.0281 0.0279
Brugia malayi jmjC domain containing protein 0.0016 0.0011 0.0056
Plasmodium falciparum JmjC domain-containing protein, putative 0.0016 0.0011 0.0245
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0074 0.0777
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0078 0.171
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0195 0.2245
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.0059 0.0604
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0018 0.0019 0.0012
Brugia malayi mbt repeat family protein 0.0048 0.0106 0.1198
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.001
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0061 0.0146 0.1645
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0281 0.0281
Echinococcus granulosus mixed lineage leukemia protein mll 0.0022 0.003 0.0024
Entamoeba histolytica diacylglycerol kinase, putative 0.0132 0.0356 0.0356
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0281 0.3522
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0053 0.0563
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0053 0.0563
Brugia malayi acetyltransferase, GNAT family protein 0.0145 0.0393 0.4648
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0053 0.0052
Mycobacterium tuberculosis Conserved hypothetical protein 0.0052 0.0118 0.0108
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0061 0.0146 0.1645
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0132 0.0356 0.0356
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0052 0.0118 0.0118
Schistosoma mansoni ferritin light chain 0.0025 0.0039 0.0039
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.005 0.0844
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0107 0.0281 0.027
Loa Loa (eye worm) hypothetical protein 0.3395 1 1
Brugia malayi Bromodomain containing protein 0.0082 0.0207 0.2409
Brugia malayi phosphofructokinase 0.0107 0.0281 0.3298
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0053 0.0047
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0089 0.0968
Plasmodium falciparum diacylglycerol kinase, putative 0.0132 0.0356 0.7771
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0053 0.0052
Brugia malayi Ceramide kinase 0.0132 0.0356 0.4203
Plasmodium falciparum DNA repair protein REV1, putative 0.0016 0.0012 0.0273
Mycobacterium ulcerans lipase LipD 0.0035 0.0069 0.0057
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0093 0.0241 0.0234
Mycobacterium ulcerans DNA polymerase IV 0.0078 0.0195 0.0183
Echinococcus multilocularis cpg binding protein 0.0092 0.0236 0.023
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0281 0.3522
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0195 0.2245
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0022 0.003 0.0024
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.005 0.0385
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0115 0.1272
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0069 0.0643
Schistosoma mansoni ferritin 0.0025 0.0039 0.0039
Schistosoma mansoni hypothetical protein 0.0093 0.0241 0.0241
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0062 0.0541
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0069 0.0058
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.005 0.0385
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0035 0.0311
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0106 0.0106
Trichomonas vaginalis rotamase, putative 0.0033 0.0062 0.0541
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0069 0.0643
Leishmania major DNA polymerase kappa, putative 0.0058 0.0138 0.1548
Plasmodium falciparum diacylglycerol kinase, putative 0.0132 0.0356 0.7771
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0062 0.0662
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0099 0.0092
Echinococcus granulosus zinc finger protein 0.0028 0.0046 0.004
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0015
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0099 0.0099
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0011 0.0011
Schistosoma mansoni ferritin 0.0025 0.0039 0.0039
Schistosoma mansoni thyroid hormone receptor 0.003 0.0053 0.0053
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.014 0.0379 0.4452
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0069 0.0752
Schistosoma mansoni hypothetical protein 0.0168 0.0461 0.0461
Loa Loa (eye worm) latrophilin receptor protein 2 0.0093 0.0241 0.0239
Schistosoma mansoni jumonji/arid domain-containing protein 0.0066 0.0159 0.0159
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0053 0.0563
Loa Loa (eye worm) hypothetical protein 0.0035 0.0069 0.0067
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0099 0.0092
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.0573 0.0571
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.005 0.0594
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0019 0.0175
Schistosoma mansoni hypothetical protein 0.0298 0.0846 0.0846
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0195 0.2245
Mycobacterium ulcerans hypothetical protein 0.0156 0.0425 0.0414
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0156 0.0156
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0014 0.0014
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0022 0.003 0.0024
Trypanosoma brucei hypothetical protein, conserved 0.0132 0.0356 0.4174
Schistosoma mansoni jumonji domain containing protein 0.0059 0.0139 0.0139
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0022 0.00000000030425
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0053 0.0563
Schistosoma mansoni ap endonuclease 0.0037 0.0074 0.0074
Trypanosoma brucei phosphoglycerate kinase 0.0167 0.0458 0.5402
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0069 0.0057
Onchocerca volvulus 0.0048 0.0106 0.1532
Brugia malayi polk-prov protein 0.0042 0.0089 0.0998
Loa Loa (eye worm) RecQ helicase 0.0044 0.0096 0.0094
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0017 0.0126
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0034 0.0022
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0034 0.0034
Trypanosoma brucei DNA polymerase IV, putative 0.0078 0.0195 0.2245
Loa Loa (eye worm) hypothetical protein 0.0035 0.0069 0.0067
Trypanosoma brucei DNA polymerase IV, putative 0.0072 0.0176 0.2015
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0156 0.1769
Echinococcus granulosus FTZ F1 alpha 0.003 0.0053 0.0047
Loa Loa (eye worm) eye-specific diacylglycerol kinase 0.0132 0.0356 0.0354
Echinococcus granulosus expressed protein 0.0025 0.0039 0.0033
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0093 0.0241 0.0234
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0017 0.0006
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0034 0.0022
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0012 0.0041
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0015
Schistosoma mansoni dihydrofolate reductase 0.0208 0.0578 0.0578
Trypanosoma cruzi DNA polymerase eta, putative 0.0041 0.0086 0.0929
Echinococcus granulosus lysine specific demethylase 5A 0.0066 0.0159 0.0152
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0053 0.0563
Leishmania major diacylglycerol kinase, putative 0.0132 0.0356 0.4174
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0059 0.0604
Mycobacterium ulcerans DNA polymerase IV 0.0078 0.0195 0.0183
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0011 0.0026
Mycobacterium ulcerans beta-lactamase 0.0035 0.0069 0.0057
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0069 0.1298
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0095 0.1871
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0126 0.0119
Schistosoma mansoni diacylglycerol kinase theta 0.0132 0.0356 0.0356
Loa Loa (eye worm) hypothetical protein 0.0024 0.0034 0.0032
Brugia malayi jmjC domain containing protein 0.0016 0.0011 0.0056
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0011 0.0011
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0041 0.0086 0.1667
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0014 0.0003
Schistosoma mansoni ap endonuclease 0.0037 0.0074 0.0074
Schistosoma mansoni hypothetical protein 0.1213 0.3549 0.3549
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0034 0.0023
Brugia malayi hypothetical protein 0.0016 0.0012 0.006
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0062 0.006
Trichomonas vaginalis glutaminase, putative 0.0268 0.0756 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0052 0.0118 0.0112
Mycobacterium tuberculosis Conserved hypothetical protein 0.0156 0.0425 0.0415
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0095 0.1002
Schistosoma mansoni nuclear hormone receptor 0.003 0.0053 0.0053
Leishmania major DNA polymerase eta, putative 0.0077 0.0192 0.2206
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0053 0.0047
Toxoplasma gondii diacylglycerol kinase, putative 0.0132 0.0356 0.7643
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0012 0.001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0057 0.0057
Leishmania major mitochondrial DNA polymerase beta 0.0296 0.0839 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0011 0.0009
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0106 0.0106
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0011 0.0026
Mycobacterium ulcerans bacterioferritin BfrA 0.0025 0.0039 0.0027
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0053 0.0047
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0053 0.0563
Brugia malayi Phosphoglycerate kinase 0.0061 0.0146 0.1675
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0074 0.1609
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0106 0.0106
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.0139 0.0133
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0093 0.0241 0.0234
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0016 0.0011 0.0009
Brugia malayi Dihydrofolate reductase 0.0208 0.0578 0.6884
Trypanosoma cruzi hypothetical protein, conserved 0.0132 0.0356 0.4174
Brugia malayi Pre-SET motif family protein 0.0031 0.0057 0.0604
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0011 0.0055
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0011 0.0242
Schistosoma mansoni ferritin 0.0025 0.0039 0.0039
Schistosoma mansoni diacylglycerol kinase theta 0.0132 0.0356 0.0356
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0106 0.0106
Brugia malayi beta-lactamase family protein 0.0035 0.0069 0.0752
Echinococcus multilocularis GPCR, family 2 0.0093 0.0241 0.0234
Schistosoma mansoni nuclear receptor 0.0014 0.0007 0.0007
Trichomonas vaginalis sphingosine kinase, putative 0.0132 0.0356 0.4544
Trypanosoma brucei hypothetical protein, conserved 0.0016 0.0012 0.0041
Brugia malayi ImpB/MucB/SamB family protein 0.0077 0.0192 0.2236
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.0281 0.3269
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0005
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0012 0.006
Leishmania major DNA polymerase kappa, putative 0.0016 0.0012 0.0041
Echinococcus granulosus phd:f box containing protein 0.0016 0.0011 0.0005
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0069 0.0058
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0156 0.0154
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0024 0.0034 0.0305
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0018 0.0019 0.0012
Echinococcus multilocularis acylglycerol kinase, mitochondrial 0.0132 0.0356 0.0349
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0195 0.2245
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0022 0.00000000030425
Loa Loa (eye worm) hypothetical protein 0.003 0.0053 0.0052
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.005 0.0873
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0061 0.0146 0.1645
Brugia malayi jmjC domain containing protein 0.0016 0.0011 0.0056
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0014 0.0014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0053 0.0052
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0069 0.0722
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.014 0.0379 0.4452
Brugia malayi Pre-SET motif family protein 0.0206 0.0573 0.682
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0074 0.0072
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0026 0.0024
Schistosoma mansoni zinc finger protein 0.0028 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0035 0.0069 0.0067
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0053 0.0563
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0035 0.0311
Loa Loa (eye worm) hypothetical protein 0.0077 0.0192 0.019
Trypanosoma cruzi DNA damage repair protein, putative 0.0016 0.0012 0.0041
Trypanosoma cruzi Diacylglycerol kinase catalytic domain containing protein, putative 0.0132 0.0356 0.4174
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0027 0.0046 0.0039
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0167 0.0458 0.9906
Mycobacterium ulcerans phosphoglycerate kinase 0.0167 0.0458 0.0446
Loa Loa (eye worm) hypothetical protein 0.0295 0.0837 0.0836
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0079 0.0199 0.2292
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0069 0.0067
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0053 0.0052
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0053 0.0047
Onchocerca volvulus 0.0085 0.0216 0.323
Mycobacterium ulcerans diacylglycerol kinase 0.0132 0.0356 0.0344
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0011 0.0005
Leishmania major diacylglycerol kinase-like protein 0.0132 0.0356 0.4174
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.005 0.0594
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0018 0.0019 0.0415
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.005 0.1094
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0053 0.0563
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0019 0.0175
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0014 0.0003
Trichomonas vaginalis diacylglycerol kinase, putative 0.0132 0.0356 0.4544
Entamoeba histolytica recQ family helicase, putative 0.0024 0.0035 0.0035
Trichomonas vaginalis set domain proteins, putative 0.0234 0.0656 0.8636
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.0315 0.0313
Schistosoma mansoni phosphoglycerate kinase 0.0167 0.0458 0.0458
Trichomonas vaginalis sphingosine kinase, putative 0.0132 0.0356 0.4544
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0053 0.0563
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0011 0.0011
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0024 0.0034 0.0305
Loa Loa (eye worm) hypothetical protein 0.0093 0.0241 0.0239
Schistosoma mansoni ferritin 0.0025 0.0039 0.0039
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0167 0.0458 0.5402
Onchocerca volvulus 0.0132 0.0356 0.5373
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0156 0.1769
Brugia malayi Eye-specific diacylglycerol kinase 0.0132 0.0356 0.4203
Schistosoma mansoni apoferritin-2 0.0025 0.0039 0.0039
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0075 0.0069
Brugia malayi jmjC domain containing protein 0.0066 0.0159 0.1834
Onchocerca volvulus 0.0031 0.0057 0.0772
Mycobacterium tuberculosis Conserved protein 0.3395 1 1
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0208 0.0578 0.0567
Mycobacterium ulcerans bacterioferritin BfrB 0.0025 0.0039 0.0027
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0034 0.0334
Giardia lamblia TCP-1 chaperonin subunit beta 0.0024 0.0034 0.0492
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0106 0.01
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0167 0.0458 0.0447
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0048 0.0042
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0011 0.0005
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0088 0.0948
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0167 0.0458 0.7782
Echinococcus multilocularis dna polymerase kappa 0.0078 0.0195 0.0189
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0074 0.0777
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0156 0.0156
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0011 0.0003
Loa Loa (eye worm) hypothetical protein 0.0038 0.0076 0.0074
Onchocerca volvulus 0.0035 0.0069 0.0962
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0074 0.0063
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0067 0.0162 0.0156
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0106 0.0106
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0281 0.0281
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0296 0.0839 1
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0107 0.0281 0.4526
Schistosoma mansoni zinc finger protein 0.0014 0.0007 0.0007
Echinococcus granulosus dna polymerase kappa 0.0078 0.0195 0.0189
Echinococcus multilocularis 6 phosphofructokinase 0.0107 0.0281 0.0274
Loa Loa (eye worm) hypothetical protein 0.0016 0.0011 0.0009
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0053 0.0052
Mycobacterium tuberculosis Conserved protein 0.0035 0.0069 0.0058
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0106 0.01
Brugia malayi Diacylglycerol kinase protein 2 0.0132 0.0356 0.4203
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0167 0.0458 0.5402
Loa Loa (eye worm) hypothetical protein 0.0035 0.0069 0.0067
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.003 0.0053 0.0919
Echinococcus multilocularis alkaline phosphatase 0.0159 0.0436 0.0429
Entamoeba histolytica phosphoglycerate kinase, putative 0.0167 0.0458 0.0458
Echinococcus granulosus phosphoglycerate kinase 1 0.0167 0.0458 0.0451
Trypanosoma brucei unspecified product 0.0072 0.0176 0.2015
Leishmania major hypothetical protein, conserved 0.0132 0.0356 0.4174
Echinococcus granulosus Diacylglycerol kinase theta 0.0132 0.0356 0.0349
Mycobacterium tuberculosis Conserved protein 0.0035 0.0069 0.0058
Plasmodium vivax diacylglycerol kinase, putative 0.0132 0.0356 0.7715
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0011 0.0009
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0005
Entamoeba histolytica diacylglycerol kinase, putative 0.0132 0.0356 0.0356
Schistosoma mansoni hypothetical protein 0.0093 0.0241 0.0241
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0088 0.0948
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0053 0.0053
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0074 0.0819
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0053 0.0563
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0069 0.0639
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0005
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0024 0.0034 0.0034
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0034 0.0303
Schistosoma mansoni blooms syndrome DNA helicase 0.0035 0.0068 0.0068
Brugia malayi latrophilin 2 splice variant baaae 0.0202 0.0561 0.6677
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0034 0.0334
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0034 0.0034
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0058 0.0138 0.0127
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.005 0.0385
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0058 0.0138 0.1548
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0069 0.0062
Loa Loa (eye worm) glutaminase 0.0268 0.0756 0.0755
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0167 0.0458 0.9906
Echinococcus multilocularis zinc finger protein 0.0028 0.0046 0.004
Plasmodium vivax phosphoglycerate kinase, putative 0.0167 0.0458 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0106 0.0104
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0011 0.0005
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0005
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0053 0.0053
Plasmodium vivax diacylglycerol kinase, putative 0.0132 0.0356 0.7715
Schistosoma mansoni hypothetical protein 0.0093 0.0241 0.0241
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.005 0.0385
Echinococcus granulosus geminin 0.0168 0.0461 0.0455
Plasmodium falciparum phosphoglycerate kinase 0.0167 0.0458 1
Echinococcus multilocularis dnaJ subfamily B 0.1213 0.3549 0.3545
Trypanosoma brucei diacylglycerol kinase, putative 0.0132 0.0356 0.4174
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0034 0.0034
Trichomonas vaginalis bmru protein, putative 0.0132 0.0356 0.4544
Trypanosoma brucei Sphingosine kinase 0.0132 0.0356 0.4174
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0182 0.0502 0.0502
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0067 0.0162 0.0156
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0078 0.0078
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.0281 0.0281
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0078 0.1478
Mycobacterium ulcerans hypothetical protein 0.0035 0.0069 0.0057
Schistosoma mansoni DNA polymerase IV / kappa 0.0016 0.0012 0.0012
Onchocerca volvulus 0.0035 0.0069 0.0962
Trypanosoma cruzi DNA polymerase eta, putative 0.0077 0.0192 0.2206
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0011 0.0011
Plasmodium vivax DNA repair protein REV1, putative 0.0016 0.0012 0.0031
Onchocerca volvulus 0.0234 0.0656 1
Brugia malayi diacylglycerol kinase 0.0132 0.0356 0.4203
Loa Loa (eye worm) hypothetical protein 0.0024 0.0034 0.0032
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0174 0.0174
Schistosoma mansoni ferritin light chain 0.0025 0.0039 0.0039
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0053 0.072
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0053 0.0052
Echinococcus granulosus histone lysine methyltransferase setb 0.0048 0.0106 0.01
Echinococcus granulosus neuropeptide receptor A26 0.0454 0.1308 0.1302
Brugia malayi Calcitonin receptor-like protein seb-1 0.0295 0.0837 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0074 0.0067
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0196 0.0544 0.0537
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0053 0.0563
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0156 0.0149
Toxoplasma gondii histone lysine methyltransferase SET1 0.0168 0.0462 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0053 0.0052
Brugia malayi Bloom's syndrome protein homolog 0.0044 0.0096 0.1078
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0053 0.0563
Loa Loa (eye worm) ceramide kinase 0.0132 0.0356 0.0354
Trypanosoma cruzi diacylglycerol kinase, putative 0.0132 0.0356 0.4174
Entamoeba histolytica deoxycytidyl transferase, putative 0.0052 0.0118 0.0118
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0059 0.0604
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0039 0.008 0.1751
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.001
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0022 0.003 0.003
Brugia malayi 6-phosphofructokinase 0.0107 0.0281 0.3298
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0019 0.015
Echinococcus multilocularis neuropeptide receptor A26 0.0454 0.1308 0.1302
Trypanosoma cruzi DNA polymerase kappa, putative 0.0078 0.0195 0.2245
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0061 0.0146 0.1645
Brugia malayi hypothetical protein 0.0071 0.0174 0.2012
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.0159 0.0436 0.0429
Loa Loa (eye worm) acetyltransferase 0.0145 0.0393 0.0391
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0012 0.006
Trypanosoma cruzi diacylglycerol kinase, putative 0.0132 0.0356 0.4174
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0034 0.0034
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0156 0.1769
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0007 0.0007
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.005 0.0865
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0014 0.0007 0.0005
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0027 0.0046 0.0039
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0011 0.0005
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0011 0.0024
Loa Loa (eye worm) hypothetical protein 0.0202 0.0561 0.0559
Schistosoma mansoni bromodomain containing protein 0.0013 0.0002 0.0002
Leishmania major T-complex protein 1, beta subunit, putative 0.0024 0.0034 0.0305
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0296 0.0839 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0074 0.0061
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0012 0.0005
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0099 0.0097
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0069 0.0722
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0034 0.0022
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0057 0.005
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.001
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0053 0.0047
Schistosoma mansoni hypothetical protein 0.002 0.0025 0.0025
Schistosoma mansoni hypothetical protein 0.0202 0.0561 0.0561
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0074 0.0067
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0053 0.0053
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0126 0.0119
Brugia malayi glutaminase DH11.1 0.0268 0.0756 0.9028
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0011 0.0024
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0126 0.0126
Schistosoma mansoni terminal deoxycytidyl transferase 0.0052 0.0118 0.0118
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0053 0.0563
Brugia malayi hypothetical protein 0.0016 0.0012 0.006
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0208 0.0578 1
Brugia malayi jmjC domain containing protein 0.0016 0.0011 0.0056
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0281 0.3522
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0018 0.0019 0.0012
Brugia malayi T-complex protein 1, beta subunit 0.0024 0.0034 0.0335
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0052 0.0118 0.0117
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0018 0.0019 0.0017
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0167 0.0458 1
Trichomonas vaginalis chaperonin, putative 0.0024 0.0034 0.0171
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0074 0.1373
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0195 0.2245
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0053 0.072
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0024 0.0034 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0132 0.0356 0.4544
Leishmania major hypothetical protein, conserved 0.0132 0.0356 0.4174
Echinococcus multilocularis Diacylglycerol kinase zeta 0.0132 0.0356 0.0349
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.005 0.0256
Schistosoma mansoni hypothetical protein 0.0093 0.0241 0.0241
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0208 0.0578 0.0568
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0053 0.0563
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0053 0.0047
Echinococcus granulosus acylglycerol kinase mitochondrial 0.0132 0.0356 0.0349
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0156 0.1769
Brugia malayi nuclear receptor NHR-88 0.003 0.0053 0.0563
Toxoplasma gondii t-complex protein beta subunit 0.0024 0.0034 0.0517
Brugia malayi beta-lactamase 0.0035 0.0069 0.0752
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0053 0.0047
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0005
Echinococcus granulosus histone acetyltransferase KAT2B 0.0138 0.0374 0.0368
Loa Loa (eye worm) CXXC zinc finger family protein 0.0085 0.0216 0.0215
Trichomonas vaginalis ferritin, putative 0.0025 0.0039 0.0239
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0015
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0005
Schistosoma mansoni cpg binding protein 0.0092 0.0236 0.0236
Chlamydia trachomatis dihydrofolate reductase 0.0208 0.0578 1
Trypanosoma brucei DNA damage repair protein, putative 0.0016 0.0012 0.0041
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0061 0.0146 0.1645
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0069 0.0063
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0106 0.1532
Loa Loa (eye worm) hypothetical protein 0.003 0.0053 0.0052
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0079 0.0199 0.2292
Schistosoma mansoni thyroid hormone receptor 0.003 0.0053 0.0053
Schistosoma mansoni hypothetical protein 0.0132 0.0356 0.0356
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0167 0.0458 0.5933
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0011 0.0005
Toxoplasma gondii exonuclease III APE 0.0037 0.0074 0.1387
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.005 0.1094
Loa Loa (eye worm) hypothetical protein 0.0043 0.0093 0.0091
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0034 0.0022
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0195 0.2245
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0195 0.2245
Mycobacterium tuberculosis Conserved protein 0.0035 0.0069 0.0058
Leishmania major hypothetical protein, conserved 0.0016 0.0011 0.0026
Brugia malayi nuclear hormone receptor 0.003 0.0053 0.0563
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0053 0.0053
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.014 0.0379 0.4452
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0011 0.0005
Brugia malayi dihydrofolate reductase family protein 0.0208 0.0578 0.6884
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0022 0.00000000030425
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0017 0.0365
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0011 0.0024
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0061 0.0146 0.1645
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0011 0.0005
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.005 0.0873
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0005
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0174 0.0167
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0025 0.0039 0.0028
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0069 0.0643
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0012 0.0005
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.0053 0.0047
Trichomonas vaginalis DNA polymerase eta, putative 0.0078 0.0195 0.2364
Echinococcus granulosus neuropeptide s receptor 0.0454 0.1308 0.1302
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.005 0.0865
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0053 0.0047
Trypanosoma brucei unspecified product 0.0036 0.0071 0.0743
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0011 0.0003
Brugia malayi Latrophilin receptor protein 2 0.0093 0.0241 0.282
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0019 0.015
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.0159 0.0436 0.0429
Plasmodium vivax SET domain protein, putative 0.0031 0.0057 0.1022
Loa Loa (eye worm) jmjC domain-containing protein 0.0066 0.0159 0.0157
Loa Loa (eye worm) MBCTL1 0.0054 0.0126 0.0124
Brugia malayi 6-phosphofructokinase 0.0107 0.0281 0.3298
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0281 0.0281
Toxoplasma gondii diacylglycerol kinase accessory domain (presumed) domain-containing protein 0.0132 0.0356 0.7643
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0011 0.0011
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0017 0.0004
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0132 0.0356 0.0354
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0011 0.0005
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0296 0.0839 1
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0012 0.0041
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0052 0.0118 0.0112
Schistosoma mansoni coup transcription factor 0.003 0.0053 0.0053
Brugia malayi Bromodomain containing protein 0.0041 0.0086 0.0957
Loa Loa (eye worm) dihydrofolate reductase 0.0208 0.0578 0.0577
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0011 0.0024
Toxoplasma gondii diacylglycerol kinase catalytic domain-containing protein 0.0132 0.0356 0.7643
Schistosoma mansoni hypothetical protein 0.0015 0.0009 0.0009
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0035 0.0179
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0005
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0074 0.0819
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0022 0.00000000030425
Giardia lamblia DINP protein human, muc B family 0.0058 0.0138 0.281
Brugia malayi CXXC zinc finger family protein 0.0085 0.0216 0.2527
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0126 0.0119
Loa Loa (eye worm) hypothetical protein 0.0135 0.0364 0.0362
Echinococcus granulosus ceramide kinase 0.0132 0.0356 0.0349
Loa Loa (eye worm) hypothetical protein 0.003 0.0053 0.0052
Echinococcus multilocularis ferritin 0.0025 0.0039 0.0033
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0035 0.0069 0.0067
Brugia malayi F/Y-rich N-terminus family protein 0.0029 0.005 0.0527
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0034 0.0022
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0074 0.0777
Trypanosoma cruzi Sphingosine kinase 0.0132 0.0356 0.4174
Loa Loa (eye worm) hypothetical protein 0.0048 0.0106 0.0104
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0093 0.0241 0.0234
Echinococcus granulosus intestinal type alkaline phosphatase 0.0159 0.0436 0.0429
Mycobacterium tuberculosis Diacylglycerol kinase 0.0132 0.0356 0.0345
Loa Loa (eye worm) phosphofructokinase 0.0107 0.0281 0.0279
Loa Loa (eye worm) DR-78 0.0014 0.0007 0.0005
Onchocerca volvulus 0.0035 0.0069 0.0962
Schistosoma mansoni alkaline phosphatase 0.0159 0.0436 0.0436
Leishmania major DNA damage repair protein, putative 0.0016 0.0012 0.0041
Giardia lamblia Sgs1 DNA helicase, putative 0.0018 0.0019 0.0146
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0074 0.0074
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0095 0.1871
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0011 0.0011
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0195 0.2245
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0281 0.3522
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0167 0.0458 0.5933
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0099 0.1109
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.0139 0.0133
Entamoeba histolytica hypothetical protein, conserved 0.3395 1 1
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0132 0.0356 0.4544
Schistosoma mansoni nuclear receptor nhr-48 0.0014 0.0007 0.0007
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0053 0.0047
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0011 0.0005
Onchocerca volvulus Ceramide kinase 1 homolog 0.0132 0.0356 0.5373
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0057 0.1013
Entamoeba histolytica diacylglycerol kinase, putative 0.0132 0.0356 0.0356
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0011 0.0026
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0095 0.0089
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0074 0.0705
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.003 0.0054 0.0951
Loa Loa (eye worm) hypothetical protein 0.005 0.0113 0.0111
Trichomonas vaginalis esterase, putative 0.0035 0.0069 0.0643
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0174 0.0167
Toxoplasma gondii ABC1 family protein 0.0035 0.0069 0.1286
Trichomonas vaginalis diacylglycerol kinase, epsilon, putative 0.0132 0.0356 0.4544
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0088 0.0948
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.005 0.0865
Echinococcus multilocularis dna polymerase eta 0.0077 0.0192 0.0186
Mycobacterium ulcerans hypothetical protein 0.0024 0.0034 0.0022
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0011 0.0005
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0005
Brugia malayi hypothetical protein 0.0132 0.0356 0.4203
Schistosoma mansoni alkaline phosphatase 0.0159 0.0436 0.0436
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0099 0.0092
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0044 0.0038
Schistosoma mansoni glutaminase 0.0268 0.0756 0.0756
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0014 0.0003
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0099 0.0099
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0069 0.0058
Trypanosoma brucei Diacylglycerol kinase catalytic domain containing protein, putative 0.0132 0.0356 0.4174
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0195 0.2245
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0156 0.0149
Echinococcus granulosus dihydrofolate reductase 0.0208 0.0578 0.0572
Entamoeba histolytica diacylglycerol kinase, putative 0.0132 0.0356 0.0356
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0022 0.00000000030425
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0069 0.0069
Schistosoma mansoni DNA polymerase eta 0.0077 0.0192 0.0192
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0145 0.0393 0.0393
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0074 0.0807
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0013 0.0004 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0089 0.0968
Schistosoma mansoni diacylglycerol kinase zeta iota 0.0132 0.0356 0.0356
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0069 0.0643
Echinococcus multilocularis phosphoglycerate kinase 1 0.0167 0.0458 0.0451
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0025 0.0023
Loa Loa (eye worm) hypothetical protein 0.003 0.0053 0.0052
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0014 0.0007 0.0007
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0034 0.0022
Trichomonas vaginalis DNA helicase recq, putative 0.0044 0.0096 0.1011
Entamoeba histolytica hypothetical protein 0.0071 0.0174 0.0174
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0053 0.0047
Trichomonas vaginalis bmru protein, putative 0.0132 0.0356 0.4544
Trypanosoma cruzi DNA polymerase kappa, putative 0.0078 0.0195 0.2245
Echinococcus granulosus GPCR family 2 0.0093 0.0241 0.0234
Brugia malayi diacylglycerol kinase 0.0132 0.0356 0.4203
Leishmania major hypothetical protein, conserved 0.0035 0.0069 0.0722
Onchocerca volvulus 0.003 0.0053 0.072
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0106 0.01
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.005 0.005
Brugia malayi PHD-finger family protein 0.0033 0.0062 0.0663
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0022 0.00000000030425
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0053 0.0053
Schistosoma mansoni sphingosine kinase A B 0.3395 1 1
Echinococcus multilocularis Diacylglycerol kinase theta 0.0132 0.0356 0.0349
Leishmania major ATP-dependent phosphofructokinase 0.0107 0.0281 0.3269
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0107 0.0281 0.5765
Treponema pallidum phosphoglycerate kinase 0.0167 0.0458 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0069 0.0063
Echinococcus multilocularis intestinal type alkaline phosphatase 0.0159 0.0436 0.0429
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0024 0.0034 0.0522
Loa Loa (eye worm) hypothetical protein 0.0016 0.0011 0.0009
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0011 0.0009
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0007 0.0007
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0034 0.0303
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0106 0.0104
Trypanosoma cruzi Sphingosine kinase 0.0132 0.0356 0.4174
Schistosoma mansoni cpg binding protein 0.0085 0.0216 0.0216
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.005 0.0385
Loa Loa (eye worm) beta-lactamase 0.0035 0.0069 0.0067
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0069 0.0722
Echinococcus multilocularis ceramide kinase 0.0132 0.0356 0.0349
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0106 0.01
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0034 0.0334
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.005 0.0385
Loa Loa (eye worm) histone methyltransferase 0.0027 0.0046 0.0044
Trypanosoma brucei hypothetical protein, conserved 0.0016 0.0012 0.0041
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0053 0.0053
Echinococcus granulosus alkaline phosphatase 0.0159 0.0436 0.0429
Loa Loa (eye worm) diacylglycerol kinase 2 0.0132 0.0356 0.0354
Mycobacterium ulcerans glutaminase 0.0268 0.0756 0.0745
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0014 0.0008
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0079 0.0199 0.4216
Echinococcus granulosus expressed protein 0.0033 0.0062 0.0055
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0126 0.1433
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0074 0.14
Schistosoma mansoni hypothetical protein 0.0071 0.0174 0.0174
Loa Loa (eye worm) hypothetical protein 0.0035 0.0069 0.0067
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.0281 0.3269
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0053 0.0047
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0053 0.0563
Brugia malayi steroid hormone receptor 0.003 0.0053 0.0563
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0079 0.0199 0.4177
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0053 0.0047
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0035 0.0311
Loa Loa (eye worm) hypothetical protein 0.003 0.0053 0.0052
Trypanosoma cruzi DNA polymerase kappa, putative 0.0078 0.0195 0.2245
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.0059 0.1068
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0012 0.0012
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0074 0.0777
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0034 0.0303
Loa Loa (eye worm) hypothetical protein 0.0018 0.0019 0.0017
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0069 0.0057
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0005
Brugia malayi mbt repeat family protein 0.0048 0.0106 0.1198
Trypanosoma brucei DNA damage repair protein, putative 0.0016 0.0012 0.0041
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0053 0.0047
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0022 0.00000000030425
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0022 0.0031 0.0025
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0011 0.0005
Toxoplasma gondii hypothetical protein 0.0048 0.0106 0.2102
Echinococcus granulosus bloom syndrome protein 0.0044 0.0096 0.009
Schistosoma mansoni phosphoglycerate kinase 0.0167 0.0458 0.0458
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0079 0.0199 0.2292
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.009 0.0973
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0025 0.0039 0.0028
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0069 0.0058
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.009 0.0973
Loa Loa (eye worm) hypothetical protein 0.003 0.0053 0.0052
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0053 0.0047
Brugia malayi isocitrate dehydrogenase 0.0016 0.0011 0.0055
Giardia lamblia Phosphoglycerate kinase 0.0167 0.0458 1
Schistosoma mansoni DNA helicase recq1 0.0018 0.0019 0.0019
Mycobacterium ulcerans hypothetical protein 0.3395 1 1
Entamoeba histolytica hypothetical protein 0.0071 0.0174 0.0174
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0053 0.0047
Schistosoma mansoni jumonji/arid domain-containing protein 0.0066 0.0159 0.0159
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0053 0.0052
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0011 0.0009
Echinococcus multilocularis expressed protein 0.0033 0.0062 0.0055
Loa Loa (eye worm) hypothetical protein 0.0167 0.0458 0.0456
Trichomonas vaginalis diacylglycerol kinase, putative 0.0132 0.0356 0.4544
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0132 0.0356 0.4174
Echinococcus granulosus cpg binding protein 0.0092 0.0236 0.023
Trypanosoma brucei DNA polymerase eta, putative 0.0077 0.0192 0.2206
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0196 0.0544 0.0537
Schistosoma mansoni DNA helicase recq5 0.0018 0.0019 0.0019
Mycobacterium ulcerans 6-phosphofructokinase 0.0107 0.0281 0.0268
Echinococcus granulosus dna polymerase eta 0.0077 0.0192 0.0186
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.001
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0034 0.0023
Echinococcus multilocularis sphingosine kinase 1 0.3395 1 1
Leishmania major sphingosine kinase A, B, putative 0.0132 0.0356 0.4174
Trypanosoma brucei chrX additional, unordered contigs 0.0016 0.0012 0.0041
Loa Loa (eye worm) hypothetical protein 0.0024 0.0034 0.0032
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.0281 0.0279
Echinococcus multilocularis neuropeptide s receptor 0.0454 0.1308 0.1302
Loa Loa (eye worm) hypothetical protein 0.0132 0.0356 0.0354
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0005
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0069 0.0062
Brugia malayi MH2 domain containing protein 0.0118 0.0315 0.3709
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0088 0.0948
Loa Loa (eye worm) nuclear receptor NHR-67 0.0014 0.0007 0.0005
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0053 0.0053
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0132 0.0356 0.4544
Schistosoma mansoni hypothetical protein 0.0083 0.0209 0.0209
Loa Loa (eye worm) hypothetical protein 0.0042 0.0089 0.0088
Echinococcus multilocularis geminin 0.0168 0.0461 0.0455
Echinococcus multilocularis bloom syndrome protein 0.0044 0.0096 0.009
Onchocerca volvulus 0.0024 0.0034 0.0426
Trypanosoma brucei phosphoglycerate kinase, putative 0.0061 0.0146 0.1645
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0014 0.0007 0.0007
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.005 0.0385
Entamoeba histolytica hypothetical protein 0.0071 0.0174 0.0174
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.0281 0.0281
Trypanosoma cruzi DNA polymerase kappa, putative 0.0078 0.0195 0.2245
Trypanosoma brucei phosphoglycerate kinase 0.0167 0.0458 0.5402
Brugia malayi ecdysteroid receptor 0.003 0.0053 0.0563
Brugia malayi ImpB/MucB/SamB family protein 0.0052 0.0118 0.1347
Mycobacterium leprae Probable lipase LipE 0.0035 0.0069 0.0639
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0053 0.0052
Brugia malayi T-complex protein 1, beta subunit 0.0024 0.0034 0.0335
Trypanosoma brucei DNA polymerase IV, putative 0.0078 0.0195 0.2245
Echinococcus multilocularis expressed protein 0.0025 0.0039 0.0033
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0132 0.0356 0.4174
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0011 0.0005
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0099 0.0092
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0069 0.0058
Loa Loa (eye worm) T-complex protein 1 0.0024 0.0034 0.0033
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.009 0.0973
Loa Loa (eye worm) hypothetical protein 0.0054 0.0126 0.0124
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.001
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0145 0.0393 0.0386
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0099 0.0099
Brugia malayi beta-lactamase family protein 0.0035 0.0069 0.0752
Trypanosoma cruzi DNA damage repair protein, putative 0.0016 0.0012 0.0041
Brugia malayi Phosphoglycerate kinase 0.0167 0.0458 0.5431
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0053 0.0053
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0069 0.0058
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0015
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0015
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0025 0.0039 0.0094
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.0315 0.0313
Leishmania major phosphoglycerate kinase B, cytosolic 0.0167 0.0458 0.5402
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0034 0.0034
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0023 0.0032 0.0455
Schistosoma mansoni nuclear receptor 0.0014 0.0007 0.0007
Brugia malayi nuclear receptor RXR 0.0016 0.0012 0.006
Schistosoma mansoni bromodomain containing protein 0.007 0.0173 0.0173
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0016 0.0012 0.0031
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0011 0.0024

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 5 uM Inhibition of bovine liver DHFR measured every 1 min for 10 mins ChEMBL. 23792351
IZ (functional) = 8 mm Antifungal activity against Candida albicans at 200 ug/disc after 48 hrs by agar disc-diffusion method ChEMBL. 23792351
IZ (functional) = 8 mm Antibacterial activity against Escherichia coli at 200 ug/disc after 24 hrs by agar disc-diffusion method ChEMBL. 23792351
LC50 (functional) = 35.4 uM Cytotoxicity against human A549 cells after 48 hrs by MTT assay ChEMBL. 23792351
mortality (functional) = 6 % Antischistosomal activity against Schistosoma mansoni assessed as mortality at 50 ug/ml after 24 hrs by microscopic analysis ChEMBL. 23792351

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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