Detailed information for compound 1783256

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 335.357 | Formula: C19H17N3O3
  • H donors: 2 H acceptors: 4 LogP: 2.82 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1ncc(nc1O[C@@H](c1ccccc1)C)c1cccc(c1)C(=O)O
  • InChi: 1S/C19H17N3O3/c1-12(13-6-3-2-4-7-13)25-18-17(20)21-11-16(22-18)14-8-5-9-15(10-14)19(23)24/h2-12H,1H3,(H2,20,21)(H,23,24)/t12-/m1/s1
  • InChiKey: PZNIRCZONXUEPF-GFCCVEGCSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) TK/FER protein kinase 0.0103 0.0326 0.0326
Brugia malayi Protein kinase domain containing protein 0.0279 0.1878 0.1878
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0154 0.0778 0.0778
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0118 0.0459 0.0459
Giardia lamblia Kinase, CK1 Casein kinase 0.0105 0.0342 0.1365
Trichomonas vaginalis AGC family protein kinase 0.0086 0.0174 0.0736
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0152 0.0756 0.1119
Loa Loa (eye worm) SRC-1 0.0229 0.1441 0.1441
Loa Loa (eye worm) hypothetical protein 0.0353 0.2533 0.2532
Echinococcus granulosus defective proboscis extension response 0.0128 0.0548 0.0662
Giardia lamblia Kinase, CMGC CDK 0.0115 0.043 0.1907
Echinococcus granulosus tyrosine protein kinase Fyn 0.0229 0.1441 0.1749
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0232 0.1459 0.2164
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.0176 0.0745
Giardia lamblia Kinase, NEK 0.0132 0.0579 0.2834
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0154 0.0778 0.4239
Entamoeba histolytica protein kinase, putative 0.0124 0.0515 0.186
Giardia lamblia Kinase, CMGC CK2 0.0096 0.0268 0.0909
Loa Loa (eye worm) hypothetical protein 0.0181 0.1013 0.1012
Toxoplasma gondii AGC kinase 0.0109 0.038 0.1634
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0423 0.3151 0.383
Echinococcus multilocularis activin receptor type 0.0078 0.0102 0.0146
Echinococcus multilocularis casein kinase i 0.0105 0.0342 0.0503
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.008 0.0127 0.0144
Schistosoma mansoni kinase 0.0281 0.1897 0.4007
Loa Loa (eye worm) AUR protein kinase 0.0086 0.0174 0.0174
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0187 0.1069 0.1068
Trypanosoma brucei SNF1-related protein kinases, putative 0.0086 0.0176 0.0414
Echinococcus granulosus cGMP dependent protein kinase 1 0.013 0.0566 0.0684
Schistosoma mansoni serine/threonine protein kinase 0.0074 0.0067 0.0109
Brugia malayi Protein kinase domain containing protein 0.0207 0.1245 0.1245
Echinococcus granulosus cGMP dependent protein kinase 0.013 0.0566 0.0684
Brugia malayi Protein kinase domain containing protein 0.0103 0.0326 0.0326
Loa Loa (eye worm) hypothetical protein 0.0452 0.3403 0.3403
Brugia malayi Protein kinase domain containing protein 0.0586 0.4586 0.4586
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0081 0.0135 0.038
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0087 0.0183 0.0624
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0263 0.1738 1
Schistosoma mansoni serine/threonine protein kinase 0.0197 0.1154 0.2424
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0263 0.1738 0.2578
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0229 0.1433 0.1739
Loa Loa (eye worm) TK/FER protein kinase 0.0103 0.0326 0.0326
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0405 0.2985 0.4432
Schistosoma mansoni serine/threonine protein kinase 0.018 0.1008 0.2114
Brugia malayi P38 map kinase family protein 2 0.0154 0.0778 0.0778
Echinococcus multilocularis Immunoglobulin 0.0128 0.0548 0.0809
Echinococcus granulosus STE20 serine:threonine protein kinase 0.0483 0.3674 0.4465
Echinococcus granulosus dual specificity 0.0135 0.0604 0.073
Schistosoma mansoni protein kinase 0.0258 0.1692 0.3569
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0187 0.1069 0.1068
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0068 0.0015 0.0017
Trypanosoma cruzi cdc2-related kinase 1 0.0115 0.043 0.215
Brugia malayi Protein kinase domain containing protein 0.0921 0.7539 0.7539
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0109 0.038 0.0559
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.0304 0.0615
Echinococcus granulosus mitogen activated protein kinase 11 0.0154 0.0778 0.0942
Echinococcus multilocularis N chimaerin 0.0097 0.0274 0.0401
Echinococcus granulosus serine:threonine kinase SAD 1 0.0086 0.0176 0.0209
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative 0.0086 0.0176 0.0449
Entamoeba histolytica PH domain containing protein kinase, putative 0.0118 0.0457 0.1645
Brugia malayi Protein kinase domain containing protein 0.0187 0.1069 0.1068
Brugia malayi Immunoglobulin I-set domain containing protein 0.0141 0.066 0.066
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0149 0.0733 0.0887
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0124 0.0515 0.2523
Entamoeba histolytica casein kinase, putative 0.0105 0.0342 0.1216
Brugia malayi Tyrosine-protein kinase abl-1 0.0125 0.0524 0.0524
Loa Loa (eye worm) TK/ROR protein kinase 0.0077 0.0098 0.0098
Echinococcus granulosus protein kinase 0.0148 0.0726 0.0879
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0068 0.0015 0.0017
Schistosoma mansoni serine/threonine protein kinase 0.0106 0.0353 0.0719
Entamoeba histolytica protein kinase, putative 0.0098 0.0285 0.1006
Brugia malayi Variant SH3 domain containing protein 0.0096 0.0267 0.0267
Echinococcus multilocularis tyrosine protein kinase Abl 0.0221 0.1366 0.2025
Schistosoma mansoni serine/threonine protein kinase 0.0384 0.2808 0.5947
Entamoeba histolytica protein kinase domain containing protein 0.0086 0.0174 0.0591
Brugia malayi Protein kinase domain containing protein 0.0195 0.1138 0.1137
Brugia malayi casein kinase I 0.0105 0.0342 0.0342
Trichomonas vaginalis CAMK family protein kinase 0.0263 0.1738 0.9237
Schistosoma mansoni protein kinase 0.0083 0.0146 0.0279
Schistosoma mansoni protein kinase 0.0358 0.2571 0.5442
Schistosoma mansoni serine/threonine protein kinase 0.0086 0.0176 0.0341
Echinococcus granulosus phosphorylase kinase gamma subunit 0.0159 0.0821 0.0994
Trichomonas vaginalis CMGC family protein kinase 0.008 0.0127 0.0479
Loa Loa (eye worm) hypothetical protein 0.0128 0.0548 0.0548
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.0176 0.0745
Schistosoma mansoni serine/threonine protein kinase 0.0105 0.0342 0.0695
Trichomonas vaginalis CMGC family protein kinase 0.0135 0.0604 0.3072
Trichomonas vaginalis AGC family protein kinase 0.0279 0.1878 1
Trichomonas vaginalis STE family protein kinase 0.0132 0.0579 0.2939
Loa Loa (eye worm) hypothetical protein 0.007 0.0039 0.0038
Schistosoma mansoni protein kinase 0.0083 0.0146 0.0279
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0097 0.0275 0.0329
Echinococcus granulosus rho-associated protein kinase 1 0.0317 0.2212 0.2686
Schistosoma mansoni growth factor receptor-bound protein 0.0098 0.0285 0.0573
Brugia malayi Protein kinase domain containing protein 0.0438 0.3278 0.3277
Schistosoma mansoni serine/threonine protein kinase 0.0086 0.0176 0.0341
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.014 0.0653 0.0965
Trichomonas vaginalis CMGC family protein kinase 0.008 0.0127 0.0479
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.0438 0.3278 0.3277
Entamoeba histolytica protein kinase, putative 0.008 0.0121 0.0394
Echinococcus granulosus expressed protein 0.008 0.0121 0.0143
Echinococcus granulosus casein kinase I alpha 0.0105 0.0342 0.0411
Schistosoma mansoni serine/threonine kinase 0.0189 0.1082 0.2271
Plasmodium vivax tyrosine kinase-like protein, putative 0.0078 0.0103 0.1366
Trichomonas vaginalis CMGC family protein kinase 0.0135 0.0604 0.3072
Entamoeba histolytica protein kinase domain containing protein 0.0124 0.0515 0.186
Schistosoma mansoni serine/threonine protein kinase 0.0207 0.1245 0.2619
Echinococcus granulosus insulin receptor 0.0441 0.3308 0.402
Trichomonas vaginalis CAMK family protein kinase 0.0263 0.1738 0.9237
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.008 0.0127 0.0138
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.0275 0.0552
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.008 0.0127 0.0126
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0097 0.0275 0.0402
Echinococcus granulosus serine:threonine protein kinase MARK2 0.014 0.0655 0.0792
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.0176 0.0745
Trichomonas vaginalis AGC family protein kinase 0.0086 0.0174 0.0736
Trichomonas vaginalis CAMK family protein kinase 0.0263 0.1738 0.9237
Schistosoma mansoni protein kinase C mu 0.0212 0.1283 0.2699
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0081 0.0135 0.038
Echinococcus granulosus roundabout 2 0.0072 0.0055 0.0062
Schistosoma mansoni hypothetical protein 0.007 0.0034 0.0039
Plasmodium falciparum serine/threonine protein kinase, putative 0.0086 0.0174 0.11
Schistosoma mansoni serine/threonine protein kinase 0.0232 0.1459 0.3075
Entamoeba histolytica protein kinase, putative 0.0086 0.0174 0.0591
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0078 0.0102 0.0185
Echinococcus multilocularis neuroglian 0.0158 0.0815 0.1205
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0086 0.0176 0.0175
Loa Loa (eye worm) thyroid receptor interactor 0.0115 0.0428 0.0428
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.0216 0.1323 0.1961
Loa Loa (eye worm) casein kinase 0.0177 0.0975 0.0974
Plasmodium vivax glycogen synthase kinase 3, putative 0.0124 0.0515 0.6808
Echinococcus granulosus neuroglian 0.0158 0.0815 0.0986
Brugia malayi Fibronectin type III domain containing protein 0.0141 0.066 0.066
Loa Loa (eye worm) TK protein kinase 0.0271 0.181 0.181
Trichomonas vaginalis AGC family protein kinase 0.0086 0.0174 0.0736
Giardia lamblia Kinase, CMGC DYRK 0.0135 0.0604 0.2985
Entamoeba histolytica protein kinase, putative 0.0135 0.0604 0.2192
Onchocerca volvulus 0.0103 0.0326 0.0321
Onchocerca volvulus 0.0317 0.2212 0.2455
Brugia malayi Serine/threonine-protein kinase SULU 0.0216 0.1323 0.1322
Trichomonas vaginalis CK1 family protein kinase 0.0105 0.0342 0.1649
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0257 0.1686 0.1686
Loa Loa (eye worm) TK/FER protein kinase 0.04 0.2947 0.2947
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0152 0.0756 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0118 0.0457 0.1645
Echinococcus multilocularis aurora kinase A 0.0086 0.0174 0.0253
Echinococcus granulosus serine:threonine protein kinase TAO1 0.0216 0.1323 0.1605
Trichomonas vaginalis CMGC family protein kinase 0.0115 0.043 0.2125
Trypanosoma cruzi serine/arginine-rich protein specific kinase SRPK, putative 0.008 0.0121 0.0299
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.008 0.0127 0.0332
Onchocerca volvulus 0.0105 0.0342 0.0338
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0078 0.0102 0.0146
Loa Loa (eye worm) hypothetical protein 0.0141 0.066 0.066
Echinococcus granulosus cyclin dependent kinase 9 0.0083 0.0146 0.0173
Echinococcus multilocularis neuroglian 0.0072 0.0055 0.0075
Brugia malayi cell division control protein 2 homolog 0.0115 0.043 0.0429
Brugia malayi protein kinase C3,putative 0.0153 0.0766 0.0765
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0115 0.043 0.1927
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0096 0.0268 0.3547
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0187 0.1069 0.1295
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.0135 0.0604 0.0603
Schistosoma mansoni atypical protein kinase C 0.0277 0.1863 0.3934
Brugia malayi Sex muscle abnormal protein 5 0.0096 0.0267 0.0267
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0149 0.0731 0.3698
Echinococcus granulosus casein kinase I alpha 0.0105 0.0342 0.0411
Onchocerca volvulus 0.0995 0.8197 0.923
Schistosoma mansoni serine/threonine protein kinase 0.0149 0.0733 0.1528
Loa Loa (eye worm) CAMK protein kinase 0.0074 0.0067 0.0066
Echinococcus multilocularis casein kinase I delta 0.0105 0.0342 0.0503
Leishmania major casein kinase II, putative 0.0096 0.0268 0.1015
Trichomonas vaginalis CMGC family protein kinase 0.0115 0.043 0.2125
Loa Loa (eye worm) hypothetical protein 0.0136 0.0616 0.0616
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0158 0.0807 0.0977
Schistosoma mansoni serine/threonine protein kinase 0.014 0.0655 0.1361
Schistosoma mansoni protein kinase 0.0148 0.0726 0.1514
Loa Loa (eye worm) hypothetical protein 0.0084 0.0159 0.0159
Loa Loa (eye worm) AGC/PKG protein kinase 0.013 0.0566 0.0566
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0241 0.1544 0.1874
Brugia malayi Protein kinase domain containing protein 0.0103 0.0326 0.0326
Echinococcus granulosus nervana 2 0.0184 0.104 0.126
Loa Loa (eye worm) AGC/NDR protein kinase 0.0149 0.0733 0.0733
Echinococcus multilocularis insulin receptor 0.0441 0.3308 0.4911
Brugia malayi RhoGAP domain containing protein 0.0097 0.0274 0.0273
Trichomonas vaginalis CMGC family protein kinase 0.0135 0.0604 0.3072
Echinococcus multilocularis c src tyrosine kinase 0.0143 0.0681 0.1007
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0384 0.2808 0.2808
Leishmania major protein kinase A catalytic subunit isoform 1 0.0109 0.038 0.1697
Echinococcus multilocularis tyrosine protein kinase 0.0282 0.1903 0.2822
Echinococcus multilocularis cyclin dependent kinase 9 0.0083 0.0146 0.0212
Echinococcus granulosus dual specificity 0.0135 0.0604 0.073
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0078 0.0107 0.0126
Echinococcus granulosus casein kinase I gamma 0.0207 0.1245 0.151
Echinococcus granulosus N chimaerin 0.0097 0.0274 0.0328
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0115 0.043 0.2002
Trichomonas vaginalis AGC family protein kinase 0.0078 0.0107 0.0373
Trichomonas vaginalis AGC family protein kinase 0.0086 0.0176 0.0744
Schistosoma mansoni tyrosine kinase 0.0241 0.1544 0.3255
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0109 0.038 0.1563
Brugia malayi hypothetical protein 0.0141 0.066 0.066
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0078 0.0102 0.012
Loa Loa (eye worm) TK/FER protein kinase 0.0103 0.0326 0.0326
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0097 0.0275 0.1014
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0072 0.0055 0.0075
Plasmodium vivax casein kinase 1, putative 0.0105 0.0342 0.4523
Echinococcus granulosus casein kinase ii subunit alpha 0.0096 0.0268 0.0322
Schistosoma mansoni neuroglian 0.0072 0.0055 0.0083
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0227 0.1421 0.1724
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0124 0.0515 0.2429
Loa Loa (eye worm) hypothetical protein 0.0096 0.0267 0.0267
Schistosoma mansoni ephrin receptor 0.0165 0.0869 0.1817
Onchocerca volvulus Serine\/threonine kinase homolog 0.0263 0.1738 0.1919
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.0176 0.0745
Brugia malayi Protein kinase domain containing protein 0.0149 0.0733 0.0733
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.0586 0.4586 0.4586
Echinococcus multilocularis cyclin dependent kinase 9 0.0075 0.0078 0.011
Brugia malayi Immunoglobulin I-set domain containing protein 0.0072 0.0055 0.0054
Trichomonas vaginalis CMGC family protein kinase 0.0096 0.0268 0.1248
Loa Loa (eye worm) AUR protein kinase 0.0086 0.0174 0.0174
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0306 0.2118 0.3142
Brugia malayi Casein kinase II, alpha chain 0.0096 0.0268 0.0268
Brugia malayi p70 ribosomal S6 kinase beta 0.027 0.1801 0.1801
Loa Loa (eye worm) hypothetical protein 0.014 0.0651 0.0651
Echinococcus granulosus maternal embryonic leucine zipper kinase 0.0111 0.0398 0.0479
Echinococcus granulosus tyrosine protein kinase HCK 0.0133 0.0591 0.0715
Brugia malayi Immunoglobulin I-set domain containing protein 0.0072 0.0055 0.0054
Plasmodium falciparum NIMA related kinase 1 0.0132 0.0579 0.7295
Trichomonas vaginalis CAMK family protein kinase 0.0122 0.0495 0.2481
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0096 0.0267 0.0536
Schistosoma mansoni tyrosine kinase 0.0229 0.1441 0.3035
Schistosoma mansoni serine/threonine protein kinase 0.0216 0.1323 0.2784
Echinococcus granulosus serine:threonine protein kinase 3 0.025 0.1622 0.1969
Schistosoma mansoni serine/threonine protein kinase 0.0078 0.0107 0.0196
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0109 0.038 0.4243
Entamoeba histolytica protein kinase domain containing protein 0.0135 0.0604 0.2192
Echinococcus multilocularis mitogen activated protein kinase 0.008 0.0127 0.0183
Trichomonas vaginalis CMGC family protein kinase 0.0124 0.0515 0.2589
Brugia malayi phosphoinositide-dependent protein kinase I 0.0078 0.0107 0.0107
Echinococcus granulosus mitogen activated protein kinase 14 0.0154 0.0778 0.0942
Echinococcus multilocularis casein kinase I gamma 0.0207 0.1245 0.1845
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0132 0.0579 0.7661
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0358 0.2571 0.3124
Giardia lamblia Kinase, CMGC CDK 0.0115 0.043 0.1907
Echinococcus granulosus cyclin dependent kinase 0.0115 0.043 0.0518
Loa Loa (eye worm) hypothetical protein 0.0285 0.1932 0.1931
Brugia malayi Protein kinase domain containing protein 0.008 0.0121 0.0121
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.014 0.0653 0.079
Echinococcus granulosus tyrosine protein kinase 0.0282 0.1903 0.231
Schistosoma mansoni hypothetical protein 0.0109 0.0383 0.0782
Schistosoma mansoni tyrosine kinase 0.0312 0.2171 0.4589
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0109 0.038 0.0379
Trichomonas vaginalis STE family protein kinase 0.0081 0.0135 0.0522
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0086 0.0176 0.0175
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.014 0.0655 0.0967
Schistosoma mansoni vav2 0.0106 0.0351 0.0714
Leishmania major casein kinase, putative 0.0105 0.0342 0.1466
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0083 0.0146 0.0173
Giardia lamblia Aurora kinase 0.0086 0.0174 0.0327
Loa Loa (eye worm) TK/FER protein kinase 0.0103 0.0326 0.0326
Echinococcus granulosus tyrosine protein kinase Src42A 0.0229 0.1441 0.1749
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0086 0.0176 0.0255
Trypanosoma brucei protein kinase, putative 0.0124 0.0515 0.2323
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0086 0.0176 0.0626
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.0081 0.0135 0.0444
Schistosoma mansoni cell adhesion molecule 0.017 0.0919 0.1924
Schistosoma mansoni rap gtpase-activating protein 0.0109 0.0383 0.0782
Trichomonas vaginalis CMGC family protein kinase 0.0135 0.0604 0.3072
Schistosoma mansoni growth factor receptor-bound protein 0.0096 0.0267 0.0536
Giardia lamblia Kinase, PLK 0.0263 0.1738 1
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.025 0.1622 0.1621
Echinococcus granulosus protein kinase shaggy 0.0124 0.0515 0.0622
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.014 0.0655 0.0967
Echinococcus granulosus raf serine:threonine protein kinase 0.0088 0.0193 0.023
Brugia malayi SRC-1 0.0229 0.1441 0.1441
Loa Loa (eye worm) hypothetical protein 0.0177 0.0978 0.0977
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.0176 0.0745
Entamoeba histolytica protein kinase, putative 0.0118 0.0459 0.1653
Schistosoma mansoni serine/threonine protein kinase 0.008 0.0127 0.0237
Entamoeba histolytica serine/threonine protein kinase, putative 0.0086 0.0176 0.0597
Schistosoma mansoni vesicular amine transporter 0.0128 0.0548 0.1134
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0149 0.0731 0.073
Toxoplasma gondii aurora kinase 0.0086 0.0174 0.0423
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0072 0.0055 0.0075
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0229 0.1441 0.2136
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0275 0.1282
Onchocerca volvulus 0.0074 0.0067 0.0026
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0149 0.0733 0.1084
Entamoeba histolytica protein kinase, putative 0.007 0.0036 0.0078
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0122 0.0492 0.2382
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0109 0.0383 0.0782
Brugia malayi Temporarily assigned gene name protein 59 0.0126 0.0532 0.0531
Entamoeba histolytica protein kinase, putative 0.027 0.1801 0.6651
Brugia malayi SH2 domain containing protein 0.04 0.2947 0.2947
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0097 0.0275 0.0274
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0212 0.1283 0.1283
Echinococcus granulosus serine:threonine protein kinase MARK2 0.014 0.0655 0.0792
Trichomonas vaginalis CMGC family protein kinase 0.0115 0.043 0.2125
Entamoeba histolytica PH domain containing protein kinase, putative 0.0161 0.0834 0.3047
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0229 0.1441 0.2136
Echinococcus granulosus mitogen activated protein kinase 0.008 0.0127 0.0149
Schistosoma mansoni serine/threonine protein kinase 0.0118 0.0458 0.0941
Echinococcus granulosus mitogen activated protein kinase 3 0.008 0.0127 0.0149
Schistosoma mansoni titin 0.0074 0.0067 0.0109
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.0176 0.0745
Brugia malayi Protein kinase domain containing protein 0.0118 0.0459 0.0459
Entamoeba histolytica hypothetical protein 0.0372 0.27 1
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0109 0.0383 0.0563
Echinococcus multilocularis calcium activated potassium channel 0.0101 0.0304 0.0446
Toxoplasma gondii cell-cycle-associated protein kinase SRPK, putative 0.008 0.0121 0.0112
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0124 0.0515 0.0514
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0326 0.2295 0.2294
Echinococcus granulosus tyrosine protein kinase Blk 0.0189 0.1086 0.1317
Echinococcus granulosus tyrosine protein kinase ABL1 0.0306 0.2118 0.2572
Leishmania major protein kinase, putative 0.0149 0.0731 0.3841
Loa Loa (eye worm) TK/ALK protein kinase 0.0279 0.1874 0.1874
Echinococcus multilocularis serine threonine protein kinase 0.0189 0.1086 0.1609
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0072 0.0055 0.0075
Brugia malayi Homeodomain interacting protein kinase protein 1 0.0197 0.1154 0.1153
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0149 0.0733 0.1084
Trichomonas vaginalis CMGC family protein kinase 0.0096 0.0268 0.1248
Echinococcus multilocularis dual specificity 0.0135 0.0604 0.0892
Schistosoma mansoni vam6/vps39 related 0.0109 0.0383 0.0782
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.0176 0.0745
Trypanosoma cruzi Protein kinase B 0.0161 0.0834 0.4573
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0263 0.1738 0.1738
Brugia malayi Protein kinase domain containing protein 0.0441 0.3308 0.3307
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0083 0.0146 0.0212
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0072 0.0055 0.0054
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0229 0.1441 0.1749
Echinococcus multilocularis mitogen activated protein kinase 14 0.0154 0.0778 0.1151
Echinococcus multilocularis serine:threonine protein kinase N2 0.0127 0.0538 0.0793
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0187 0.1069 0.1068
Schistosoma mansoni serine/threonine protein kinase 0.0075 0.0078 0.0133
Loa Loa (eye worm) hypothetical protein 0.0068 0.0018 0.0018
Brugia malayi Fes/CIP4 homology domain containing protein 0.0115 0.0428 0.0428
Loa Loa (eye worm) TK/FER protein kinase 0.0103 0.0326 0.0326
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0109 0.0383 0.1868
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0384 0.2808 0.4169
Entamoeba histolytica protein kinase, putative 0.007 0.0036 0.0078
Entamoeba histolytica cell division protein kinase 2, putative 0.0115 0.043 0.1543
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.04 0.2947 0.4375
Brugia malayi Immunoglobulin I-set domain containing protein 0.0072 0.0055 0.0054
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0212 0.1283 0.1283
Schistosoma mansoni adapter molecule crk 0.0096 0.0267 0.0536
Entamoeba histolytica protein kinase, putative 0.0279 0.1878 0.6938
Echinococcus multilocularis tyrosine protein kinase shark 0.0312 0.2171 0.3221
Brugia malayi cyclin-dependent kinase 9 0.0075 0.0078 0.0077
Echinococcus granulosus calcium activated potassium channel 0.0101 0.0304 0.0365
Echinococcus granulosus serine:threonine protein kinase 0.007 0.0039 0.0042
Echinococcus granulosus roundabout 2 0.02 0.1185 0.1437
Echinococcus multilocularis ephrin type A receptor 4 A 0.0178 0.0984 0.1457
Plasmodium falciparum calcium-dependent protein kinase 3 0.0097 0.0275 0.2634
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0074 0.0067 0.0066
Echinococcus multilocularis serine:threonine protein kinase 0.007 0.0039 0.0052
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0097 0.0275 0.0402
Loa Loa (eye worm) hypothetical protein 0.0087 0.0189 0.0188
Echinococcus multilocularis rho associated protein kinase 0.0317 0.2212 0.3282
Onchocerca volvulus 0.0286 0.1941 0.2149
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0068 0.0015 0.0014
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0229 0.1441 0.2136
Trichomonas vaginalis CAMK family protein kinase 0.0111 0.0398 0.1951
Echinococcus granulosus casein kinase i 0.0105 0.0342 0.0411
Echinococcus granulosus cyclin dependent kinase 5 0.0115 0.043 0.0518
Plasmodium falciparum calcium-dependent protein kinase 1 0.0097 0.0275 0.2634
Echinococcus granulosus casein kinase I alpha 0.0105 0.0342 0.0411
Trichomonas vaginalis AGC family protein kinase 0.0158 0.081 0.4194
Entamoeba histolytica protein kinase, putative 0.0097 0.0275 0.0965
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0257 0.1686 0.2501
Brugia malayi protein kinase C II. 0.0191 0.1105 0.1105
Giardia lamblia Kinase, CAMK CAMKL 0.0094 0.0244 0.0759
Echinococcus granulosus tyrosine protein kinase Fyn 0.0229 0.1441 0.1749
Echinococcus multilocularis dual specificity 0.0135 0.0604 0.0892
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.0586 0.4586 0.4586
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0078 0.0103 0.0006
Loa Loa (eye worm) CMGC/CDK/CDK9 protein kinase 0.0075 0.0078 0.0077
Loa Loa (eye worm) protein kinase domain-containing protein 0.0207 0.1245 0.1245
Echinococcus granulosus serine:threonine protein kinase 0.007 0.0039 0.0042
Giardia lamblia Kinase, AGC PKA 0.0152 0.0756 0.3928
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0109 0.0383 0.1579
Schistosoma mansoni tyrosine kinase 0.0366 0.2648 0.5605
Loa Loa (eye worm) AGC/PKN protein kinase 0.0276 0.1853 0.1852
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.013 0.0566 0.273
Schistosoma mansoni serine/threonine protein kinase 0.013 0.0566 0.1172
Trypanosoma brucei serine/arginine-rich protein specific kinase SRPK, putative 0.008 0.0121 0.0107
Loa Loa (eye worm) hypothetical protein 0.0125 0.0517 0.0516
Trichomonas vaginalis AGC family protein kinase 0.0078 0.0107 0.0373
Echinococcus granulosus casein kinase I delta 0.0105 0.0342 0.0411
Loa Loa (eye worm) AGC/AKT protein kinase 0.0279 0.1878 0.1878
Brugia malayi protein unc-22 0.0074 0.0067 0.0066
Schistosoma mansoni serine/threonine protein kinase 0.0149 0.0731 0.1523
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0109 0.038 0.0559
Loa Loa (eye worm) hypothetical protein 0.0109 0.0383 0.0382
Echinococcus granulosus homeodomain interacting protein kinase 3 0.0197 0.1154 0.1399
Echinococcus granulosus fibroblast growth factor receptor 4 0.0241 0.1544 0.1874
Echinococcus granulosus titin 0.0074 0.0067 0.0076
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0358 0.2571 0.3816
Trypanosoma brucei Casein kinase II 0.0096 0.0268 0.0935
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0109 0.038 0.1634
Loa Loa (eye worm) hypothetical protein 0.0072 0.0055 0.0054
Echinococcus multilocularis cyclin dependent kinase 5 0.0115 0.043 0.0633
Trichomonas vaginalis CMGC family protein kinase 0.0096 0.0268 0.1248
Trypanosoma cruzi cdc2-related kinase 3 0.0115 0.043 0.215
Trypanosoma cruzi casein kinase, putative 0.0105 0.0342 0.1624
Echinococcus granulosus tyrosine protein kinase Fyn 0.0229 0.1441 0.1749
Echinococcus granulosus NCK adaptor protein 0.0096 0.0267 0.032
Loa Loa (eye worm) hypothetical protein 0.019 0.109 0.1089
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0454 0.342 0.4156
Echinococcus multilocularis cyclin dependent kinase 1 0.0115 0.043 0.0633
Loa Loa (eye worm) hypothetical protein 0.0188 0.1073 0.1073
Echinococcus multilocularis cyclin dependent kinase 7 0.0106 0.0353 0.0519
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0083 0.0146 0.0173
Brugia malayi Protein kinase domain containing protein 0.0358 0.2571 0.2571
Entamoeba histolytica protein kinase, putative 0.0083 0.0146 0.0488
Trichomonas vaginalis CAMK family protein kinase 0.0111 0.0398 0.1951
Schistosoma mansoni tyrosine kinase 0.0143 0.0681 0.1418
Trypanosoma cruzi cdc2-related kinase 1 0.0115 0.043 0.215
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0189 0.1086 0.1317
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0115 0.043 0.0518
Schistosoma mansoni tyrosine kinase 0.06 0.4712 1
Schistosoma mansoni serine/threonine protein kinase 0.0118 0.0459 0.0945
Brugia malayi probable protein kinase 0.0258 0.1692 0.1691
Trichomonas vaginalis AGC family protein kinase 0.0279 0.1878 1
Echinococcus multilocularis mitogen activated protein kinase 11 0.0154 0.0778 0.1151
Trichomonas vaginalis STE family protein kinase 0.0083 0.0146 0.0586
Echinococcus multilocularis 0.017 0.0918 0.1358
Loa Loa (eye worm) hypothetical protein 0.0141 0.066 0.066
Loa Loa (eye worm) hypothetical protein 0.0353 0.2533 0.2532
Trypanosoma brucei polo-like protein kinase 0.0263 0.1738 0.921
Loa Loa (eye worm) hypothetical protein 0.0118 0.0455 0.0454
Plasmodium falciparum casein kinase 2, alpha subunit 0.0096 0.0268 0.2538
Brugia malayi Protein kinase domain containing protein 0.0586 0.4586 0.4586
Loa Loa (eye worm) hypothetical protein 0.008 0.0121 0.0121
Echinococcus multilocularis roundabout 2 0.02 0.1185 0.1756
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0078 0.0107 0.0154
Leishmania major protein kinase, putative 0.0081 0.0135 0.0199
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.0176 0.0745
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0232 0.1459 0.1771
Onchocerca volvulus 0.0118 0.0455 0.0466
Brugia malayi serine/threonine-protein kinase 6 0.0086 0.0174 0.0174
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0229 0.1441 0.2136
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0358 0.2571 0.2571
Trichomonas vaginalis AGC family protein kinase 0.0279 0.1878 1
Echinococcus multilocularis nervana 2 0.0184 0.104 0.1539
Schistosoma mansoni tyrosine kinase 0.0396 0.2914 0.6172
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0132 0.0579 0.2809
Brugia malayi Protein kinase domain containing protein 0.0282 0.1903 0.1902
Echinococcus granulosus serine:threonine protein kinase N2 0.0276 0.1853 0.225
Loa Loa (eye worm) hypothetical protein 0.0204 0.1216 0.1215
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0118 0.0459 0.2328
Echinococcus multilocularis rac serine:threonine kinase 0.0161 0.0834 0.1233
Echinococcus multilocularis roundabout 2 0.0072 0.0055 0.0075
Schistosoma mansoni protein kinase 0.0423 0.3151 0.6677
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.0135 0.0604 0.3067
Echinococcus granulosus epidermal growth factor receptor 0.06 0.4712 0.5728
Giardia lamblia Kinase, NEK 0.0132 0.0579 0.2834
Loa Loa (eye worm) hypothetical protein 0.0117 0.0445 0.0445
Echinococcus multilocularis epidermal growth factor receptor 0.06 0.4712 0.6999
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0105 0.0342 0.0342
Trichomonas vaginalis AGC family protein kinase 0.0279 0.1878 1
Loa Loa (eye worm) TK/EPH protein kinase 0.0197 0.1153 0.1153
Loa Loa (eye worm) TK protein kinase 0.0282 0.1903 0.1902
Brugia malayi map kinase activated protein kinase protein 2 0.0384 0.2808 0.2808
Schistosoma mansoni nck2/grb4 0.0096 0.0267 0.0536
Trypanosoma brucei cdc2-related kinase 1 0.0115 0.043 0.1844
Schistosoma mansoni protein kinase 0.0086 0.0174 0.0338
Echinococcus granulosus tyrosine protein kinase Lyn 0.026 0.1712 0.2078
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0083 0.0146 0.0173
Loa Loa (eye worm) hypothetical protein 0.0118 0.046 0.046
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0097 0.0275 0.1014
Loa Loa (eye worm) hypothetical protein 0.0128 0.0548 0.0548
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0097 0.0275 0.0329
Loa Loa (eye worm) hypothetical protein 0.014 0.0651 0.0651
Brugia malayi ephrin receptor 1 precursor 0.0102 0.032 0.032
Echinococcus granulosus tyrosine protein kinase shark 0.0312 0.2171 0.2636
Trypanosoma cruzi aurora B kinase, putative 0.0086 0.0174 0.0617
Schistosoma mansoni serine/threonine protein kinase 0.0106 0.0353 0.0719
Trichomonas vaginalis CMGC family protein kinase 0.0096 0.0268 0.1248
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0152 0.0756 0.411
Echinococcus multilocularis casein kinase I alpha 0.0105 0.0342 0.0503
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0323 0.2266 0.2266
Echinococcus multilocularis protein kinase c epsilon type 0.0191 0.1105 0.1637
Loa Loa (eye worm) TK protein kinase 0.0189 0.1086 0.1086
Brugia malayi Protein kinase domain containing protein 0.0103 0.0326 0.0326
Trichomonas vaginalis CMGC family protein kinase 0.0096 0.0268 0.1248
Onchocerca volvulus Serine\/threonine kinase homolog 0.0159 0.0821 0.088
Loa Loa (eye worm) hypothetical protein 0.0235 0.1489 0.1488
Onchocerca volvulus 0.0103 0.0326 0.0321
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0263 0.1738 0.211
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0115 0.043 0.0429
Echinococcus multilocularis Glutaredoxin protein 5 0.0121 0.0486 0.0716
Entamoeba histolytica protein kinase, putative 0.0118 0.0459 0.1653
Echinococcus granulosus epidermal growth factor receptor 0.0396 0.2914 0.3541
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.018 0.1008 0.1008
Trichomonas vaginalis AGC family protein kinase 0.0279 0.1878 1
Echinococcus granulosus NDR protein kinase 0.0149 0.0733 0.0887
Onchocerca volvulus 0.0124 0.0515 0.0534
Trypanosoma brucei protein kinase, putative 0.0088 0.0195 0.0523
Echinococcus multilocularis raf serine:threonine protein kinase 0.0088 0.0193 0.0281
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0229 0.1441 0.1749
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0109 0.038 0.185
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0097 0.0275 0.0274
Loa Loa (eye worm) hypothetical protein 0.0109 0.0383 0.0382
Schistosoma mansoni serine/threonine protein kinase 0.0229 0.1433 0.3019
Trichomonas vaginalis CMGC family protein kinase 0.0149 0.0731 0.3761
Trichomonas vaginalis CMGC family protein kinase 0.0096 0.0268 0.1248
Echinococcus granulosus neuroglian 0.0072 0.0055 0.0062
Trichomonas vaginalis CAMK family protein kinase 0.0271 0.1806 0.9608
Loa Loa (eye worm) TK/FER protein kinase 0.0103 0.0326 0.0326
Brugia malayi intracellular kinase 0.0124 0.0515 0.0514
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0097 0.0275 0.0274
Entamoeba histolytica hypothetical protein 0.0118 0.0459 0.1653
Echinococcus granulosus Immunoglobulin 0.0128 0.0548 0.0662
Brugia malayi MAP kinase sur-1 0.008 0.0127 0.0126
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0159 0.0818 0.0818
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0171 0.0922 0.0921
Echinococcus multilocularis serine:threonine protein kinase 3 0.025 0.1622 0.2405
Brugia malayi Tyrosine-protein kinase abl-1 0.0221 0.1366 0.1366
Schistosoma mansoni serine/threonine protein kinase 0.0191 0.1105 0.232
Trypanosoma brucei casein kinase I, isoform 2 0.0105 0.0342 0.135
Trichomonas vaginalis CK1 family protein kinase 0.0105 0.0342 0.1649
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0115 0.043 0.0429
Trichomonas vaginalis CMGC family protein kinase 0.008 0.0127 0.0479
Trypanosoma brucei aurora B kinase 0.0086 0.0174 0.0405
Onchocerca volvulus 0.0103 0.0326 0.0321
Echinococcus multilocularis cGMP dependent protein kinase 1 0.013 0.0566 0.0836
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0149 0.0731 0.3955
Brugia malayi casein kinase 1, delta 0.0105 0.0342 0.0342
Loa Loa (eye worm) hypothetical protein 0.0087 0.0189 0.0188
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0109 0.038 0.0559
Loa Loa (eye worm) hypothetical protein 0.0158 0.0807 0.0807
Entamoeba histolytica protein kinase, putative 0.0279 0.1878 0.6938
Schistosoma mansoni tyrosine kinase 0.0396 0.2914 0.6172
Schistosoma mansoni tyrosine kinase 0.0441 0.3308 0.701
Echinococcus multilocularis hypothetical protein 0.007 0.0034 0.0044
Schistosoma mansoni serine/threonine protein kinase 0.0086 0.0174 0.0338
Plasmodium falciparum serine/threonine protein kinase KIN 0.0086 0.0176 0.1123
Onchocerca volvulus 0.0103 0.0326 0.0321
Onchocerca volvulus 0.014 0.0651 0.0688
Echinococcus multilocularis serine:threonine protein kinase N2 0.0276 0.1853 0.2748
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0086 0.0174 0.0591
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0998 0.8223 1
Entamoeba histolytica protein kinase , putative 0.0086 0.0174 0.0591
Brugia malayi Egg laying defective protein 4 0.013 0.0566 0.0566
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.0176 0.0745
Entamoeba histolytica p21-activated kinase 0.0091 0.0224 0.0776
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0097 0.0274 0.0401
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.0135 0.0604 0.0603
Echinococcus granulosus aurora kinase A 0.0086 0.0174 0.0207
Brugia malayi Immunoglobulin I-set domain containing protein 0.0074 0.0067 0.0066
Loa Loa (eye worm) hypothetical protein 0.0109 0.038 0.0379
Schistosoma mansoni serine/threonine protein kinase 0.023 0.1448 0.3049
Echinococcus multilocularis maternal embryonic leucine zipper kinase 0.0111 0.0398 0.0585
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0226 0.1408 0.1408
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.0176 0.0745
Trichomonas vaginalis AGC family protein kinase 0.0109 0.038 0.1854
Echinococcus multilocularis casein kinase I alpha 0.0105 0.0342 0.0503
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.0216 0.1323 0.1322
Brugia malayi Protein kinase domain containing protein 0.007 0.0039 0.0038
Loa Loa (eye worm) hypothetical protein 0.0103 0.0326 0.0326
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0109 0.0383 0.1868
Echinococcus granulosus tyrosine protein kinase Srms 0.0502 0.3848 0.4677
Echinococcus multilocularis cyclin dependent kinase 0.0115 0.043 0.0633
Echinococcus multilocularis mitogen activated protein kinase 14 0.0154 0.0778 0.1151
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0097 0.0275 0.363
Plasmodium vivax unspecified product 0.0096 0.0268 0.3547
Echinococcus granulosus growth factor receptor bound protein 2 0.0098 0.0285 0.0341
Schistosoma mansoni serine/threonine protein kinase 0.0229 0.1433 0.3019
Echinococcus granulosus protein kinase C gamma type 0.0189 0.1086 0.1317
Echinococcus multilocularis expressed protein 0.008 0.0121 0.0175
Echinococcus multilocularis dual specificity protein kinase clk2 0.0149 0.0731 0.108
Brugia malayi Protein kinase domain containing protein 0.0103 0.0326 0.0326
Plasmodium falciparum calcium-dependent protein kinase 2 0.0097 0.0275 0.2634
Brugia malayi cyclin-dependent kinase 7 homolog 0.0114 0.0421 0.0421
Schistosoma mansoni serine/threonine protein kinase 0.0086 0.0176 0.0341
Onchocerca volvulus 0.0109 0.0383 0.0384
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0184 0.104 0.1539
Entamoeba histolytica protein kinase domain containing protein 0.0078 0.0102 0.0323
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0094 0.0244 0.3227
Entamoeba histolytica protein kinase 2, putative 0.0152 0.0756 0.276
Echinococcus multilocularis cyclin dependent kinase 1 0.0115 0.043 0.0633
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0124 0.0515 0.0514
Echinococcus granulosus tyrosine kinase 0.0189 0.1086 0.1317
Entamoeba histolytica protein kinase, putative 0.0087 0.0183 0.0624
Brugia malayi Protein kinase domain containing protein 0.0149 0.0733 0.0733
Schistosoma mansoni serine/threonine protein kinase 0.0109 0.038 0.0776
Onchocerca volvulus 0.0074 0.0071 0.0032
Loa Loa (eye worm) hypothetical protein 0.0136 0.0616 0.0616
Brugia malayi hypothetical protein 0.0109 0.0383 0.0382
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0109 0.038 0.0559
Trichomonas vaginalis AGC family protein kinase 0.0149 0.0733 0.3774
Echinococcus granulosus serine/threonine protein kinase 0.0161 0.0834 0.101
Echinococcus multilocularis 0.0148 0.0726 0.1074
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0109 0.038 0.0457
Echinococcus multilocularis mitogen activated protein kinase 11 0.0154 0.0778 0.1151
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0109 0.038 0.0457
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.0081 0.0135 0.0444
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.0304 0.0615
Echinococcus granulosus Glutaredoxin protein 5 0.0121 0.0486 0.0586
Trichomonas vaginalis CMGC family protein kinase 0.0124 0.0515 0.2589
Plasmodium falciparum cGMP-dependent protein kinase 0.013 0.0566 0.7091
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0154 0.0778 0.4131
Echinococcus multilocularis dual specificity 0.0118 0.0459 0.0677
Giardia lamblia Kinase, CAMK CAMKL 0.0094 0.0244 0.0759
Echinococcus multilocularis myosin iiia 0.0081 0.0135 0.0194
Loa Loa (eye worm) TK protein kinase 0.0133 0.0591 0.0591
Giardia lamblia Kinase, CMGC GSK 0.0124 0.0515 0.2435
Schistosoma mansoni serine/threonine protein kinase 0.0149 0.0733 0.1528
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0128 0.0548 0.1134
Trichomonas vaginalis CK1 family protein kinase 0.0105 0.0342 0.1649
Entamoeba histolytica protein kinase domain containing protein 0.0096 0.0268 0.0942
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0148 0.0726 0.0726
Brugia malayi Protein kinase domain containing protein 0.0279 0.1875 0.1875
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0109 0.038 0.0457
Schistosoma mansoni serine/threonine protein kinase 0.0088 0.0193 0.0378
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0396 0.2914 0.3541
Echinococcus granulosus ephrin type A receptor 4 A 0.0178 0.0984 0.1193
Entamoeba histolytica casein kinase 1, putative 0.0105 0.0342 0.1216
Brugia malayi Protein kinase domain containing protein 0.0159 0.0821 0.082
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0135 0.0604 0.2824
Schistosoma mansoni hypothetical protein 0.007 0.0034 0.0039
Schistosoma mansoni protein kinase 0.0078 0.0102 0.0185
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0187 0.1069 0.1161
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0124 0.0515 0.076
Echinococcus multilocularis casein kinase I delta 0.0105 0.0342 0.0503
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0083 0.0146 0.0212
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.008 0.0127 0.015
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0097 0.0275 0.363
Echinococcus multilocularis roundabout 2 0.0072 0.0055 0.0075
Brugia malayi Immunoglobulin I-set domain containing protein 0.0271 0.181 0.181
Schistosoma mansoni cell adhesion molecule 0.0072 0.0055 0.0083
Giardia lamblia Kinase, STE STE20 0.0083 0.0146 0.0155
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0086 0.0176 0.0414
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.0176 0.0745
Leishmania major protein kinase A catalytic subunit isoform 2 0.0109 0.038 0.1697
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0097 0.0275 0.1014
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.0176 0.0745
Brugia malayi C1-like domain containing protein 0.0212 0.1283 0.1283
Loa Loa (eye worm) hypothetical protein 0.0097 0.0275 0.0274
Loa Loa (eye worm) TK/FER protein kinase 0.0103 0.0326 0.0326
Trichomonas vaginalis CMGC family protein kinase 0.0135 0.0604 0.3072
Echinococcus granulosus roundabout 2 0.0072 0.0055 0.0062
Brugia malayi Protein kinase domain containing protein 0.0187 0.1069 0.1069
Loa Loa (eye worm) camk/dcamkl protein kinase 0.0146 0.0706 0.0706
Loa Loa (eye worm) hypothetical protein 0.0128 0.0551 0.055
Echinococcus multilocularis nervana 2 0.0184 0.104 0.1539
Echinococcus multilocularis growth factor receptor bound protein 2 0.0096 0.0267 0.0391
Brugia malayi Protein kinase domain containing protein 0.0103 0.0326 0.0326
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0154 0.0778 0.3804
Onchocerca volvulus 0.0181 0.1013 0.1097
Plasmodium falciparum calcium-dependent protein kinase 4 0.0097 0.0275 0.2634
Entamoeba histolytica protein kinase, putative 0.0078 0.0107 0.0342
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0097 0.0275 0.0329
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0118 0.0459 0.2328
Echinococcus granulosus dual specificity 0.0118 0.0459 0.0554
Giardia lamblia Kinase, AGC PKA 0.0109 0.038 0.1599
Schistosoma mansoni protein kinase 0.0423 0.3151 0.6677
Echinococcus multilocularis expressed conserved protein 0.013 0.0566 0.0836
Loa Loa (eye worm) AUR protein kinase 0.0086 0.0174 0.0174
Plasmodium falciparum casein kinase 1 0.0105 0.0342 0.3666
Leishmania major protein kinase, putative 0.0149 0.0731 0.3841
Echinococcus multilocularis mitogen activated protein kinase 3 0.008 0.0127 0.0183
Echinococcus multilocularis tyrosine protein kinase HCK 0.0133 0.0591 0.0873
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0232 0.1459 0.1459
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.0176 0.0745
Trypanosoma cruzi casein kinase, putative 0.0105 0.0342 0.1624
Leishmania major protein kinase A catalytic subunit 0.0109 0.038 0.1697
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0149 0.0733 0.0887
Giardia lamblia Kinase, CMGC MAPK 0.008 0.0127 0.0034
Plasmodium falciparum protein kinase 5 0.0115 0.043 0.5006
Plasmodium vivax serine/threonine protein kinase, putative 0.008 0.0121 0.1604
Loa Loa (eye worm) hypothetical protein 0.0109 0.0383 0.0382
Schistosoma mansoni serine/threonine protein kinase 0.0135 0.0604 0.1253
Schistosoma mansoni serine/threonine protein kinase 0.0149 0.0731 0.1523
Trichomonas vaginalis AGC family protein kinase 0.0086 0.0174 0.0736
Schistosoma mansoni serine/threonine kinase 0.0149 0.0733 0.1528
Echinococcus granulosus cyclin dependent kinase 9 0.0075 0.0078 0.009
Brugia malayi serine/threonine protein kinase 6 0.0086 0.0174 0.0174
Echinococcus granulosus serine threonine protein kinase nrc 0.0152 0.0756 0.0916
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0454 0.342 0.5078
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.0197 0.1154 0.1153
Brugia malayi Protein kinase domain containing protein 0.0188 0.1077 0.1077
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.018 0.1008 0.1493
Trypanosoma cruzi polo-like protein kinase, putative 0.0263 0.1738 1
Schistosoma mansoni serine/threonine protein kinase 0.013 0.0566 0.1172
Plasmodium falciparum tyrosine kinase-like protein, putative 0.0078 0.0103 0.0015
Trypanosoma brucei rac serine-threonine kinase, putative 0.0279 0.1878 1
Brugia malayi Furin-like cysteine rich region family protein 0.06 0.4712 0.4712
Toxoplasma gondii AGC kinase 0.027 0.1801 1
Loa Loa (eye worm) AGC/PKA protein kinase 0.0109 0.038 0.0379
Echinococcus granulosus tyrosine protein kinase Fps85D 0.04 0.2947 0.3581
Leishmania major protein kinase, putative 0.0086 0.0174 0.044
Brugia malayi Variant SH3 domain containing protein 0.0096 0.0267 0.0267
Schistosoma mansoni protein kinase 0.0105 0.0342 0.0695
Echinococcus multilocularis serine:threonine protein kinase 38 0.0149 0.0733 0.1084
Plasmodium vivax serine/threonine kinase-1, putative 0.0149 0.0731 0.9659
Brugia malayi Protein kinase domain 0.0083 0.0146 0.0146
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.0135 0.0604 0.2953
Entamoeba histolytica protein kinase domain containing protein 0.0075 0.0078 0.0233
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0115 0.043 0.0429
Schistosoma mansoni serine/threonine protein kinase 0.0109 0.038 0.0776
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0149 0.0731 0.3955
Loa Loa (eye worm) TK protein kinase 0.0344 0.2452 0.2452
Brugia malayi hypothetical protein 0.0103 0.0326 0.0326
Entamoeba histolytica protein kinase, putative 0.0086 0.0174 0.0591
Echinococcus granulosus Vam6:Vps39 protein 0.0109 0.0383 0.0461
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.014 0.0654 0.0967
Plasmodium falciparum calcium-dependent protein kinase 5 0.0097 0.0275 0.2634
Plasmodium vivax protein kinase Crk2 0.0115 0.043 0.5681
Loa Loa (eye worm) hypothetical protein 0.0141 0.066 0.066
Schistosoma mansoni serine/threonine protein kinase 0.0257 0.1686 0.3557
Trypanosoma brucei cdc2-related kinase 3 0.0115 0.043 0.1844
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.008 0.0127 0.0332
Echinococcus granulosus tyrosine protein kinase Src64B 0.0229 0.1441 0.1749
Schistosoma mansoni protein kinase 0.0096 0.0268 0.0538
Entamoeba histolytica cell division protein kinase 2, putative 0.0123 0.0498 0.1797
Echinococcus granulosus c src tyrosine kinase 0.0143 0.0681 0.0824
Echinococcus multilocularis dual specificity 0.0135 0.0604 0.0892
Brugia malayi hypothetical protein 0.0216 0.1323 0.1322
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0181 0.1014 0.1013
Echinococcus multilocularis titin 0.0074 0.0067 0.0093
Trichomonas vaginalis AGC family protein kinase 0.0132 0.0579 0.2939
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0152 0.0756 1
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0241 0.1544 0.2289
Schistosoma mansoni tyrosine kinase 0.0229 0.1441 0.3035
Trichomonas vaginalis STE family protein kinase 0.0083 0.0146 0.0586
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0071 0.0042 0.0041
Schistosoma mansoni serine/threonine protein kinase 0.0115 0.043 0.0882
Echinococcus granulosus Protein kinase C brain isozyme 0.023 0.1448 0.1757
Trypanosoma cruzi casein kinase II, putative 0.0096 0.0268 0.1181
Brugia malayi Stress-activated protein kinase jnk-1 0.0257 0.1686 0.1686
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0097 0.0274 0.0328
Trypanosoma cruzi polo-like protein kinase, putative 0.0263 0.1738 1
Echinococcus granulosus protein kinase c epsilon type 0.0191 0.1105 0.134
Echinococcus granulosus serine:threonine protein kinase N2 0.0127 0.0538 0.0649
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0128 0.0548 0.1134
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0097 0.0275 0.0402
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0154 0.0778 0.4239
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0086 0.0174 0.0253
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0124 0.0515 0.2661
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0109 0.038 0.185
Schistosoma mansoni tyrosine kinase 0.025 0.1623 0.3423
Toxoplasma gondii casein kinase I 0.0105 0.0342 0.1412
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0103 0.0326 0.1158
Echinococcus multilocularis STE20 serine:threonine protein kinase 0.0483 0.3674 0.5455
Echinococcus multilocularis NCK adaptor protein 0.0098 0.0285 0.0417
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0086 0.0174 0.0591
Brugia malayi Kinase associated domain 1 family protein 0.007 0.0034 0.0033
Brugia malayi Temporarily assigned gene name protein 59 0.0109 0.0383 0.0382
Schistosoma mansoni serine/threonine protein kinase 0.0263 0.1738 0.3668
Echinococcus granulosus hypothetical protein 0.0118 0.046 0.0555
Echinococcus multilocularis tyrosine kinase 0.0103 0.0326 0.0479
Echinococcus granulosus activin receptor type 0.0078 0.0102 0.012
Brugia malayi putative serine/threonine kinase SADA gamma 0.0086 0.0176 0.0175
Loa Loa (eye worm) TK/INSR protein kinase 0.0441 0.3308 0.3307
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0149 0.0731 0.3538
Plasmodium falciparum glycogen synthase kinase 3 0.0124 0.0515 0.6309
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0086 0.0174 0.2303
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative 0.0086 0.0176 0.0449
Schistosoma mansoni tyrosine kinase 0.0078 0.0103 0.0185
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0195 0.1137 0.1379
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0078 0.0107 0.0107
Loa Loa (eye worm) TK/KIN16 protein kinase 0.12 1 1
Schistosoma mansoni protein kinase 0.0078 0.0102 0.0185
Plasmodium falciparum serine/threonine protein kinase 0.008 0.0121 0.0291
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0195 0.1138 0.1137
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0109 0.038 0.185
Onchocerca volvulus Tyrosine kinase homolog 0.1073 0.8877 1
Plasmodium falciparum protein serine/threonine kinase-1 0.0149 0.0731 0.9606
Schistosoma mansoni serine/threonine-protein kinase 0.0161 0.0834 0.1742
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0109 0.038 0.1563
Echinococcus multilocularis 0.0118 0.046 0.0678
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0105 0.0342 0.0342
Echinococcus multilocularis tyrosine protein kinase Blk 0.0189 0.1086 0.1609
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0113 0.0415 0.0414
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.0304 0.0615
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.0081 0.0135 0.0183
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0229 0.1433 0.2125
Entamoeba histolytica protein kinase, putative 0.008 0.0121 0.0394
Entamoeba histolytica protein kinase, putative 0.0133 0.0591 0.2145
Onchocerca volvulus 0.0103 0.0326 0.0321
Entamoeba histolytica protein kinase domain containing protein 0.0124 0.0515 0.186
Loa Loa (eye worm) hypothetical protein 0.0136 0.0616 0.0616
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0103 0.0325 0.0325
Brugia malayi STE20-like kinase MST 0.025 0.1622 0.1621
Brugia malayi Protein kinase domain containing protein 0.0188 0.1072 0.1071
Trichomonas vaginalis CMGC family protein kinase 0.008 0.0127 0.0479
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0083 0.0146 0.0212
Trichomonas vaginalis AGC family protein kinase 0.0149 0.0733 0.3774
Schistosoma mansoni protein kinase 0.0187 0.1069 0.2243
Echinococcus granulosus c-Jun N-terminal kinases 0.0257 0.1686 0.2047
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0097 0.0274 0.055
Schistosoma mansoni serine/threonine protein kinase 0.008 0.0121 0.0225
Schistosoma mansoni serine/threonine protein kinase 0.023 0.1448 0.3049
Trichomonas vaginalis AGC family protein kinase 0.0279 0.1878 1
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0195 0.1137 0.1685
Loa Loa (eye worm) TK/FER protein kinase 0.0103 0.0326 0.0326
Schistosoma mansoni serine/threonine protein kinase 0.0195 0.1138 0.2389
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0072 0.0055 0.0075
Trichomonas vaginalis CAMK family protein kinase 0.0181 0.1014 0.5299
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0109 0.0383 0.0461
Brugia malayi Doublecortin family protein 0.0146 0.0706 0.0706
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0097 0.0275 0.363
Echinococcus granulosus nervana 2 0.0184 0.104 0.126
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0072 0.0055 0.0062
Brugia malayi serine/threonine-protein kinase plk-2 0.0263 0.1738 0.1738
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0097 0.0274 0.055
Entamoeba histolytica serine/threonine protein kinase, putative 0.0263 0.1738 0.6416
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0068 0.0015 0.0014
Echinococcus multilocularis serine:threonine protein kinase 0.007 0.0039 0.0052
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.0197 0.1154 0.1709
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0135 0.0604 0.3195
Loa Loa (eye worm) TK/FER protein kinase 0.0103 0.0326 0.0326
Loa Loa (eye worm) hypothetical protein 0.0586 0.4586 0.4586
Schistosoma mansoni protein kinase 0.0423 0.3151 0.6677
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0124 0.0515 0.1063
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0086 0.0176 0.0626
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0078 0.0109 0.0128
Loa Loa (eye worm) hypothetical protein 0.007 0.0034 0.0033
Toxoplasma gondii AGC kinase 0.0109 0.038 0.1634
Brugia malayi Hr1 repeat family protein 0.0276 0.1853 0.1852
Echinococcus granulosus cGMP dependent protein kinase 1 0.013 0.0566 0.0684
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0118 0.0459 0.2011
Giardia lamblia Kinase, CMGC GSK 0.0124 0.0515 0.2435
Loa Loa (eye worm) CMGC/SRPK protein kinase 0.008 0.0121 0.0121
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0109 0.038 0.5021
Toxoplasma gondii histone kinase SNF1, putative 0.0086 0.0176 0.0432
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.0176 0.0745
Schistosoma mansoni serine/threonine protein kinase 0.014 0.0655 0.1361
Trichomonas vaginalis CAMK family protein kinase 0.0263 0.1738 0.9237
Echinococcus granulosus contactin 0.0072 0.0055 0.0062
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.018 0.1008 0.1222
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0072 0.0055 0.0083
Trichomonas vaginalis CMGC family protein kinase 0.0096 0.0268 0.1248
Giardia lamblia Kinase, AGC AKT 0.0113 0.0415 0.1815
Entamoeba histolytica protein kinase domain containing protein 0.0197 0.1154 0.4239
Echinococcus multilocularis serine:threonine protein kinase N2 0.0149 0.0733 0.1084
Brugia malayi Protein kinase domain containing protein 0.0181 0.1014 0.1013
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0115 0.043 0.2002
Loa Loa (eye worm) CAMK/PHK protein kinase 0.0159 0.0821 0.082
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0326 0.2295 0.2294
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0118 0.0462 0.2303
Echinococcus granulosus dual specificity protein kinase clk2 0.0149 0.0731 0.0884
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0184 0.104 0.126
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0405 0.2985 0.3628
Brugia malayi serine/threonine-protein kinase PAK 7 0.0226 0.1408 0.1408
Trichomonas vaginalis STE family protein kinase 0.0083 0.0146 0.0586
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0097 0.0275 0.097
Schistosoma mansoni serine/threonine protein kinase 0.0086 0.0176 0.0341
Schistosoma mansoni serine/threonine protein kinase 0.0276 0.1853 0.3912
Schistosoma mansoni tyrosine kinase 0.035 0.25 0.529
Trichomonas vaginalis AGC family protein kinase 0.0279 0.1878 1
Brugia malayi SH2 domain containing protein 0.0103 0.0326 0.0326
Echinococcus multilocularis casein kinase I alpha 0.0105 0.0342 0.0503
Echinococcus multilocularis epidermal growth factor receptor 0.0396 0.2914 0.4326
Schistosoma mansoni serine/threonine protein kinase 0.0317 0.2212 0.4677
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0097 0.0274 0.0273
Loa Loa (eye worm) hypothetical protein 0.0188 0.1073 0.1073
Plasmodium vivax calcium-dependent protein kinase, putative 0.0097 0.0275 0.363
Onchocerca volvulus 0.0136 0.0616 0.0649
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0128 0.0548 0.0809
Brugia malayi Cam kinase protein 1 0.0097 0.0275 0.0274
Schistosoma mansoni tyrosine kinase 0.0143 0.0681 0.1418
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0384 0.2808 0.3412
Echinococcus granulosus titin 0.0074 0.0067 0.0076
Giardia lamblia Kinase, STE STE20 0.0081 0.0135 0.0083
Mycobacterium ulcerans hypothetical protein 0.01 0.0295 0.5
Schistosoma mansoni tyrosine kinase 0.035 0.25 0.529
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0187 0.1069 0.1583
Echinococcus granulosus twitchin 0.0189 0.1085 0.1316
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0144 0.0689 0.1019
Entamoeba histolytica protein kinase domain containing protein 0.0118 0.0459 0.1653
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.007 0.0039 0.0038
Loa Loa (eye worm) CMGC/CDK/CDK7 protein kinase 0.0106 0.0353 0.0353
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.0176 0.0745
Loa Loa (eye worm) AGC/PKA protein kinase 0.0109 0.038 0.0379
Loa Loa (eye worm) TK/ABL protein kinase 0.0306 0.2118 0.2117
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.014 0.0654 0.0792
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0152 0.0756 0.0916
Echinococcus granulosus casein kinase I delta 0.0105 0.0342 0.0411
Echinococcus granulosus cyclin dependent kinase 7 0.0106 0.0353 0.0425
Entamoeba histolytica PH domain containing protein kinase, putative 0.0161 0.0834 0.3047
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0921 0.7539 0.7539
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0149 0.0731 0.3955
Toxoplasma gondii CMGC kinase, CK2 family 0.0096 0.0268 0.0977
Trichomonas vaginalis CMGC family protein kinase 0.0135 0.0604 0.3072
Brugia malayi Protein kinase c protein 2 0.0112 0.0403 0.0402
Schistosoma mansoni serine/threonine protein kinase 0.0248 0.1606 0.3387
Trypanosoma cruzi casein kinase, putative 0.0105 0.0342 0.1624
Schistosoma mansoni tyrosine kinase 0.0441 0.3308 0.701
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0149 0.0731 0.3955
Schistosoma mansoni serine/threonine protein kinase 0.0109 0.038 0.0776
Echinococcus multilocularis cGMP dependent protein kinase 1 0.013 0.0566 0.0836
Trypanosoma cruzi casein kinase, putative 0.0105 0.0342 0.1624
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.0176 0.0745
Trichomonas vaginalis CAMK family protein kinase 0.0263 0.1738 0.9237
Echinococcus multilocularis death associated protein kinase 1 0.0829 0.6731 1
Onchocerca volvulus 0.019 0.109 0.1185
Schistosoma mansoni serine/threonine protein kinase 0.0159 0.0821 0.1715
Trichomonas vaginalis CAMK family protein kinase 0.0263 0.1738 0.9237
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0086 0.0174 0.0591
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0149 0.0731 0.3538
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0105 0.0342 0.1624
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.008 0.0127 0.015
Schistosoma mansoni tyrosine kinase 0.0106 0.0357 0.0727
Onchocerca volvulus 0.0103 0.0326 0.0321
Loa Loa (eye worm) hypothetical protein 0.0086 0.0176 0.0175
Schistosoma mansoni tyrosine kinase 0.0256 0.1676 0.3535
Schistosoma mansoni tyrosine kinase 0.035 0.25 0.529
Loa Loa (eye worm) hypothetical protein 0.0141 0.0658 0.0657
Brugia malayi protein-tyrosine kinase 0.0189 0.1086 0.1086
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0149 0.0733 0.0733
Trypanosoma cruzi casein kinase, putative 0.0105 0.0342 0.1624
Entamoeba histolytica protein kinase, putative 0.0149 0.0733 0.2672
Loa Loa (eye worm) hypothetical protein 0.0227 0.1421 0.142
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0229 0.1441 0.2136
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0229 0.1441 0.2136
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0191 0.1105 0.1105
Brugia malayi Variant SH3 domain containing protein 0.0097 0.0274 0.0273
Loa Loa (eye worm) TK/EGFR protein kinase 0.06 0.4712 0.4712
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0096 0.0267 0.0267
Schistosoma mansoni serine/threonine protein kinase 0.0115 0.043 0.0882
Echinococcus granulosus dual specificity 0.0135 0.0604 0.073
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0105 0.0342 0.0342
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.008 0.0121 0.0117
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0096 0.0267 0.0267
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0109 0.038 0.185
Brugia malayi Protein kinase domain containing protein 0.0149 0.0731 0.073
Trichomonas vaginalis AGC family protein kinase 0.0157 0.0801 0.4145
Schistosoma mansoni nephrin 0.0072 0.0055 0.0083
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0109 0.038 0.1563
Echinococcus multilocularis Protein kinase C, brain isozyme 0.023 0.1448 0.2146
Brugia malayi Protein kinase domain containing protein 0.0078 0.0107 0.0107
Trypanosoma cruzi cdc2-related kinase 3 0.0115 0.043 0.215
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0241 0.1544 0.2289
Trichomonas vaginalis CAMK family protein kinase 0.0122 0.0495 0.2481
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.027 0.1801 0.1801
Echinococcus granulosus tyrosine kinase 0.0103 0.0326 0.0392
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0124 0.0515 0.0622
Schistosoma mansoni kinase 0.0075 0.0078 0.0133
Leishmania major protein kinase, putative 0.0097 0.0275 0.1053
Loa Loa (eye worm) STE/STE20/SLK protein kinase 0.0187 0.1069 0.1069
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0161 0.0834 0.4573
Giardia lamblia Kinase, CMGC CLK 0.0149 0.0731 0.3769
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0077 0.0098 0.0114
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0189 0.1086 0.1609
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0109 0.0383 0.0782
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0096 0.0268 0.0268
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.008 0.0127 0.0332
Echinococcus multilocularis protein kinase shaggy 0.0124 0.0515 0.076
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0086 0.0174 0.0207
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0423 0.3151 0.4679
Echinococcus multilocularis casein kinase ii subunit alpha 0.0096 0.0268 0.0393
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.018 0.1008 0.1008
Brugia malayi Protein kinase domain containing protein 0.0115 0.043 0.0429
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0078 0.0109 0.0156
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0229 0.1441 0.2136
Brugia malayi serine/threonine kinase 12 0.0086 0.0174 0.0174
Schistosoma mansoni protein kinase 0.0078 0.0102 0.0185
Echinococcus multilocularis Immunoglobulin 0.0128 0.0548 0.0809
Schistosoma mansoni serine/threonine-protein kinase 0.0161 0.0834 0.1742
Echinococcus granulosus cyclin dependent kinase 1 0.0115 0.043 0.0518
Schistosoma mansoni serine/threonine protein kinase 0.0466 0.3523 0.7469
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0078 0.0102 0.0185
Schistosoma mansoni serine/threonine protein kinase 0.0187 0.1069 0.2242
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0229 0.1441 0.2136
Entamoeba histolytica casein kinase, putative 0.0096 0.0268 0.0942
Schistosoma mansoni nephrin 0.0171 0.0926 0.194
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.008 0.0127 0.0332
Schistosoma mansoni cell adhesion molecule 0.0072 0.0055 0.0083
Echinococcus granulosus protein kinase c iota type 0.0271 0.181 0.2198
Giardia lamblia Kinase, NEK 0.0132 0.0579 0.2834
Schistosoma mansoni ste20-related kinase 0.0199 0.1175 0.247
Echinococcus multilocularis phosphorylase kinase gamma subunit 0.0159 0.0821 0.1214
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0118 0.0459 0.2183
Echinococcus granulosus tyrosine protein kinase Src42A 0.0144 0.0689 0.0834
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0229 0.1441 0.2136
Echinococcus multilocularis protein kinase c iota type 0.0271 0.181 0.2685
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0143 0.0681 0.1418
Trichomonas vaginalis STE family protein kinase 0.0083 0.0146 0.0586
Echinococcus multilocularis tyrosine protein kinase Srms 0.0189 0.1086 0.1609
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0077 0.0098 0.014
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.0176 0.0745

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 100 uM Inhibition of human recombinant carboxy-terminal his-tagged LDHB (1 to 333) expressed in Escherichia coli using pyruvate as substrate assessed as disappearance of NADH after 10 mins by fluorescence assay ChEMBL. 24012183
IC50 (binding) > 100 uM Inhibition of human recombinant carboxy-terminal his-tagged LDHA (1 to 331) expressed in Escherichia coli using pyruvate as substrate assessed as disappearance of NADH after 10 mins by fluorescence assay ChEMBL. 24012183
Kd (binding) > 100 uM Binding affinity to human recombinant carboxy-terminal his-tagged LDHA (1 to 331) expressed in Escherichia coli by surface plasmon resonance analysis in presence of NADH ChEMBL. 24012183

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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