Detailed information for compound 1985766

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 352.43 | Formula: C20H24N4O2
  • H donors: 2 H acceptors: 2 LogP: 1.14 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1N(C2CCN(CC2)Cc2ccc[nH]2)C(=O)c2c1cccc2C(=O)N
  • InChi: 1S/C20H24N4O2/c1-13-16-5-2-6-17(19(21)25)18(16)20(26)24(13)15-7-10-23(11-8-15)12-14-4-3-9-22-14/h2-6,9,13,15,22H,7-8,10-12H2,1H3,(H2,21,25)
  • InChiKey: RLNVMGITCMKRAG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens poly (ADP-ribose) polymerase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus poly ADP ribose polymerase 1 Get druggable targets OG5_128423 All targets in OG5_128423
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative Get druggable targets OG5_128423 All targets in OG5_128423
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein Get druggable targets OG5_128423 All targets in OG5_128423
Echinococcus multilocularis poly (adp ribose) polymerase 2 Get druggable targets OG5_128423 All targets in OG5_128423
Trypanosoma congolense poly(ADP-ribose) polymerase, putative Get druggable targets OG5_128423 All targets in OG5_128423
Schistosoma mansoni poly [ADP-ribose] polymerase Get druggable targets OG5_128423 All targets in OG5_128423
Entamoeba histolytica poly(ADP-ribose) polymerase, putative Get druggable targets OG5_128423 All targets in OG5_128423
Trypanosoma brucei poly(adp-ribose) polymerase Get druggable targets OG5_128423 All targets in OG5_128423
Echinococcus granulosus poly (ADP ribose) polymerase Get druggable targets OG5_128423 All targets in OG5_128423
Loa Loa (eye worm) poly(ADP-ribose) polymerase Get druggable targets OG5_128423 All targets in OG5_128423
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128423 All targets in OG5_128423
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative Get druggable targets OG5_128423 All targets in OG5_128423
Echinococcus granulosus WGR domain containing protein Get druggable targets OG5_128423 All targets in OG5_128423
Entamoeba histolytica hypothetical protein Get druggable targets OG5_128423 All targets in OG5_128423
Trypanosoma brucei gambiense poly(ADP-ribose) polymerase, putative Get druggable targets OG5_128423 All targets in OG5_128423
Schistosoma mansoni poly [ADP-ribose] polymerase Get druggable targets OG5_128423 All targets in OG5_128423
Schistosoma japonicum Poly [ADP-ribose] polymerase 2-A, putative Get druggable targets OG5_128423 All targets in OG5_128423
Schistosoma japonicum Poly [ADP-ribose] polymerase 1, putative Get druggable targets OG5_128423 All targets in OG5_128423
Echinococcus granulosus poly (ADP ribose) polymerase Get druggable targets OG5_128423 All targets in OG5_128423
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128423 All targets in OG5_128423
Echinococcus granulosus poly adp ribose polymerase 2 Get druggable targets OG5_128423 All targets in OG5_128423
Schistosoma mansoni poly [ADP-ribose] polymerase Get druggable targets OG5_128423 All targets in OG5_128423
Echinococcus multilocularis poly (ADP ribose) polymerase Get druggable targets OG5_128423 All targets in OG5_128423
Schistosoma japonicum Poly [ADP-ribose] polymerase 1, putative Get druggable targets OG5_128423 All targets in OG5_128423
Echinococcus multilocularis poly (ADP ribose) polymerase 1 Get druggable targets OG5_128423 All targets in OG5_128423
Schistosoma japonicum Poly [ADP-ribose] polymerase 2, putative Get druggable targets OG5_128423 All targets in OG5_128423
Brugia malayi WGR domain containing protein Get druggable targets OG5_128423 All targets in OG5_128423
Schistosoma japonicum ko:K00774 NAD ADP-ribosyltransferase [EC2.4.2.30], putative Get druggable targets OG5_128423 All targets in OG5_128423
Neospora caninum hypothetical protein Get druggable targets OG5_128423 All targets in OG5_128423
Brugia malayi WGR domain containing protein Get druggable targets OG5_128423 All targets in OG5_128423
Echinococcus granulosus poly (ADP ribose) polymerase Get druggable targets OG5_128423 All targets in OG5_128423
Schistosoma japonicum Poly [ADP-ribose] polymerase 2, putative Get druggable targets OG5_128423 All targets in OG5_128423
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus survival motor neuron protein 1 0.0269 0.2776 0.2862
Trypanosoma brucei DNA polymerase kappa, putative 0.0237 0.242 0.6723
Brugia malayi hypothetical protein 0.008 0.0689 0.0975
Mycobacterium leprae Probable two-component sensor kinase 0.0031 0.0144 0.1434
Trypanosoma brucei heat shock protein, putative 0.0135 0.1295 0.3597
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0095 0.0857 0.238
Schistosoma mansoni hypothetical protein 0.0152 0.1484 0.153
Echinococcus granulosus heat shock protein 0.0135 0.1295 0.1336
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0041 0.0253 0.07
Entamoeba histolytica recQ family helicase, putative 0.0061 0.0476 0.2162
Schistosoma mansoni heat shock protein 0.0135 0.1295 0.1336
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0038 0.0159
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.045 0.1249
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.004 0.0239 0.08
Trypanosoma brucei DNA polymerase kappa, putative 0.0113 0.1055 0.293
Plasmodium vivax heat shock protein 90, putative 0.0065 0.0525 0.223
Mycobacterium ulcerans hypothetical protein 0.0038 0.0226 0.0757
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0072 0.0598 0.0809
Trypanosoma cruzi PAB1-binding protein , putative 0.0081 0.0694 0.1927
Echinococcus granulosus poly adp ribose polymerase 2 0.0095 0.0857 0.0884
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0024 0.0068 0.0068
Onchocerca volvulus DNA topoisomerase 2 homolog 0.013 0.1241 0.2102
Loa Loa (eye worm) hypothetical protein 0.024 0.246 0.3325
Echinococcus granulosus phd:f box containing protein 0.0026 0.0094 0.0097
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0152 0.148 0.8204
Schistosoma mansoni protein phosphatase 2C 0.0026 0.0094 0.0097
Schistosoma mansoni hypothetical protein 0.0347 0.3641 0.3754
Echinococcus granulosus muscleblind protein 0.017 0.168 0.1732
Loa Loa (eye worm) hypothetical protein 0.0087 0.0768 0.1038
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0057 0.0437 0.113
Schistosoma mansoni jumonji/arid domain-containing protein 0.0103 0.0937 0.0966
Echinococcus granulosus transcription factor Dp 1 0.0043 0.0282 0.0291
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0067 0.0547 0.1517
Echinococcus multilocularis lamin b receptor 0.0071 0.0582 0.0582
Loa Loa (eye worm) histone methyltransferase 0.002 0.0028 0.0037
Brugia malayi hypothetical protein 0.0042 0.0262 0.0371
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.008 0.0689 0.0689
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0046 0.0311 0.0441
Treponema pallidum DNA gyrase, subunit A (gyrA) 0.0034 0.018 0.1662
Trypanosoma brucei DNA polymerase IV, putative 0.0237 0.242 0.6723
Trypanosoma brucei DNA polymerase kappa, putative 0.0237 0.242 0.6723
Leishmania major hypothetical protein, conserved 0.0026 0.0085 0.0145
Leishmania major C-14 sterol reductase, putative 0.0071 0.0582 0.1539
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0185 0.185 0.1908
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0185 0.185 0.2619
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.004 0.0239 0.08
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0241 0.0808
Leishmania major hypothetical protein, conserved 0.0023 0.0053 0.0053
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0031 0.0144 0.0482
Echinococcus granulosus cpg binding protein 0.0066 0.0536 0.0553
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0241 0.0808
Leishmania major hypothetical protein, conserved 0.0081 0.0694 0.1853
Trichomonas vaginalis DNA helicase recq, putative 0.0061 0.0476 0.1597
Toxoplasma gondii Hsp90 domain-containing protein 0.023 0.2353 1
Brugia malayi RNA binding protein 0.0072 0.0598 0.0847
Trypanosoma cruzi heat shock protein 85, putative 0.0135 0.1295 0.3597
Brugia malayi Steroid receptor seven-up type 2 0.0185 0.185 0.2619
Loa Loa (eye worm) fli-1 protein 0.0503 0.5372 0.7261
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0129
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0118 0.0121
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0025 0.0081 0.0084
Echinococcus multilocularis transfer RNA-Lys 0.0092 0.082 0.082
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0065 0.0525 0.0541
Echinococcus multilocularis lamin dm0 0.0025 0.0073 0.0073
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0087 0.0768 0.0792
Loa Loa (eye worm) hypothetical protein 0.0057 0.0429 0.0579
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0181 0.1811 0.1811
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0266 0.0738
Brugia malayi jmjC domain containing protein 0.0154 0.1504 0.2128
Leishmania major hypothetical protein, conserved 0.0031 0.0144 0.031
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0052 0.038 0.0391
Leishmania major heat shock protein 83-1 0.0135 0.1295 0.3538
Leishmania major heat shock protein 83-1 0.0135 0.1295 0.3538
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.007 0.0582 0.5394
Loa Loa (eye worm) hypothetical protein 0.0087 0.0768 0.1038
Brugia malayi hypothetical protein 0.0018 0.0001 0.0001
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0008 0.0063
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0258 0.2654 0.2736
Trypanosoma cruzi DNA damage repair protein, putative 0.0038 0.0226 0.0627
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0162 0.1599 0.4441
Trypanosoma cruzi DNA polymerase kappa, putative 0.0237 0.242 0.6723
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0087 0.0768 0.0768
Loa Loa (eye worm) hypothetical protein 0.0098 0.0884 0.1195
Plasmodium vivax DNA gyrase subunit B, putative 0.0115 0.1078 0.4579
Trypanosoma brucei polo-like protein kinase 0.0217 0.2201 0.6113
Loa Loa (eye worm) hypothetical protein 0.0039 0.023 0.0311
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.0226 0.0959
Onchocerca volvulus 0.0029 0.0118 0.0198
Entamoeba histolytica transcription factor BTF3, putative 0.004 0.0241 0.1094
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0018 0.0001 0.0000015891
Echinococcus multilocularis Niemann Pick C1 protein 0.0112 0.104 0.104
Schistosoma mansoni cpg binding protein 0.0066 0.0536 0.0553
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0026 0.0085 0.0236
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Plasmodium falciparum ataxin-2 like protein, putative 0.0081 0.0694 0.2949
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0077 0.0122
Plasmodium falciparum DNA topoisomerase 2 0.0181 0.1811 0.7695
Plasmodium falciparum ataxin-2 like protein, putative 0.0081 0.0694 0.2949
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0598 0.0617
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0343 0.36 1
Trypanosoma brucei DNA topoisomerase ii 0.0201 0.2026 0.5626
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.004 0.0239 0.0576
Onchocerca volvulus Huntingtin homolog 0.024 0.246 0.4169
Trypanosoma brucei DNA repair protein, putative 0.0023 0.0053 0.0144
Onchocerca volvulus 0.0212 0.2145 0.3634
Echinococcus multilocularis heat shock protein 90 0.0135 0.1295 0.1295
Schistosoma mansoni DNA topoisomerase II 0.0181 0.1811 0.1867
Trypanosoma brucei DNA polymerase kappa, putative 0.0237 0.242 0.6723
Echinococcus granulosus Niemann Pick C1 protein 0.016 0.1571 0.162
Loa Loa (eye worm) hypothetical protein 0.0087 0.0768 0.1038
Schistosoma mansoni hypothetical protein 0.0036 0.0202 0.0208
Echinococcus multilocularis mitogen activated protein kinase 3 0.0059 0.045 0.045
Mycobacterium ulcerans DNA polymerase IV 0.0237 0.242 0.8126
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0059 0.045 0.1911
Brugia malayi ecdysone receptor 0.0087 0.0768 0.1087
Entamoeba histolytica hypothetical protein 0.0152 0.1484 0.674
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0104
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.045 0.151
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0185 0.185 0.2619
Trypanosoma cruzi heat shock protein, putative 0.0065 0.0525 0.1457
Schistosoma mansoni thyroid hormone receptor 0.0443 0.4703 0.4848
Echinococcus granulosus mitogen activated protein kinase 0.0059 0.045 0.0464
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0036 0.0202 0.0208
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0008 0.0029
Schistosoma mansoni hypothetical protein 0.0046 0.0311 0.0321
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0077 0.0109
Echinococcus multilocularis bloom syndrome protein 0.0094 0.0847 0.0847
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0185 0.185 0.1908
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0065 0.0525 0.0889
Trichomonas vaginalis CAMK family protein kinase 0.0217 0.2201 0.7388
Onchocerca volvulus DNA topoisomerase 2 homolog 0.013 0.1241 0.2102
Brugia malayi CHE-14 protein 0.0048 0.0333 0.0471
Brugia malayi hypothetical protein 0.0018 0.0001 0.0001
Trypanosoma cruzi DNA polymerase kappa, putative 0.0237 0.242 0.6723
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0008 0.0023
Loa Loa (eye worm) hypothetical protein 0.0087 0.0768 0.1038
Brugia malayi hypothetical protein 0.0081 0.0694 0.0983
Trypanosoma brucei heat shock protein, putative 0.0135 0.1295 0.3597
Echinococcus granulosus expressed conserved protein 0.0105 0.0965 0.0995
Leishmania major heat shock protein 83-1 0.0135 0.1295 0.3538
Schistosoma mansoni smad 0.0019 0.0008 0.0008
Echinococcus granulosus lysine specific demethylase 6a 0.0026 0.0094 0.0097
Trypanosoma brucei DNA damage repair protein, putative 0.0038 0.0226 0.0627
Schistosoma mansoni hypothetical protein 0.0046 0.0314 0.0324
Brugia malayi nuclear receptor NHR-67 0.0087 0.0768 0.1087
Brugia malayi hypothetical protein 0.0087 0.0768 0.1087
Trypanosoma cruzi sterol C-24 reductase, putative 0.0071 0.0582 0.1616
Leishmania major protein kinase, putative 0.0045 0.0302 0.0752
Echinococcus granulosus lamin 0.0025 0.0073 0.0076
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0048 0.0333 0.045
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0027 0.0096 0.0265
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0173 0.1716 0.4765
Toxoplasma gondii isocitrate dehydrogenase 0.0036 0.0202 0.0856
Echinococcus multilocularis tar DNA binding protein 0.0072 0.0598 0.0598
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0598 0.0617
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0185 0.185 0.2501
Loa Loa (eye worm) pax transcription factor protein 2 0.0551 0.59 0.7974
Echinococcus granulosus tumor susceptibility gene 101 protein 0.008 0.0689 0.071
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0226 0.0627
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0048 0.0336 0.0931
Loa Loa (eye worm) hypothetical protein 0.0112 0.104 0.1405
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0042 0.0267 0.0377
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0036 0.0202 0.0202
Brugia malayi Nuclear hormone receptor E75 0.0087 0.0768 0.1087
Echinococcus granulosus Nuclear hormone receptor HR96 0.0087 0.0768 0.0792
Echinococcus multilocularis peregrin 0.0027 0.0095 0.0095
Loa Loa (eye worm) transcription factor SMAD2 0.0273 0.2827 0.382
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0067 0.0547 0.2481
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0031 0.0144 0.0761
Echinococcus multilocularis phd:f box containing protein 0.0026 0.0094 0.0094
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.0632 0.1754
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0217 0.2201 0.2201
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0267 0.0739
Echinococcus multilocularis endoplasmin 0.0108 0.1001 0.1001
Trypanosoma cruzi PAB1-binding protein , putative 0.0081 0.0694 0.1927
Trypanosoma cruzi sterol C-24 reductase, putative 0.0071 0.0582 0.1616
Loa Loa (eye worm) hypothetical protein 0.0026 0.0094 0.0127
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0075 0.0632 0.1677
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0185 0.185 0.185
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0038 0.0126
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0059 0.045 0.1249
Leishmania major heat shock protein 83-1 0.0135 0.1295 0.3538
Trypanosoma brucei DNA polymerase IV, putative 0.0208 0.211 0.5861
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0038 0.0039
Brugia malayi hypothetical protein 0.0092 0.0826 0.1169
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0201 0.2026 0.5626
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0036 0.0202 0.0559
Schistosoma mansoni hypothetical protein 0.0894 0.9699 1
Brugia malayi Pre-SET motif family protein 0.0191 0.1915 0.271
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0052 0.038 0.038
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0077 0.0122
Schistosoma mansoni rotamase 0.0069 0.0565 0.0582
Entamoeba histolytica deoxycytidyl transferase, putative 0.0124 0.117 0.5313
Mycobacterium ulcerans DNA gyrase subunit B 0.0115 0.1078 0.3617
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.0021 0.0034 0.0306
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0038 0.0171
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0185 0.185 0.2619
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0077 0.0388
Echinococcus multilocularis sterol regulatory element binding protein 0.0048 0.0333 0.0333
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0024 0.0068 0.0092
Schistosoma mansoni nuclear hormone receptor 0.0185 0.185 0.1908
Brugia malayi hypothetical protein 0.0152 0.1484 0.21
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0108 0.1001 0.5538
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0185 0.185 0.2619
Loa Loa (eye worm) hypothetical protein 0.0087 0.0768 0.1038
Loa Loa (eye worm) MH2 domain-containing protein 0.0273 0.2827 0.382
Loa Loa (eye worm) hypothetical protein 0.0029 0.0118 0.0159
Mycobacterium ulcerans heat shock protein 90 0.0108 0.1001 0.3361
Plasmodium falciparum heat shock protein 90, putative 0.0061 0.0477 0.2023
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0038 0.0126
Loa Loa (eye worm) hypothetical protein 0.0031 0.0144 0.0195
Onchocerca volvulus 0.0551 0.59 1
Schistosoma mansoni hypothetical protein 0.0347 0.3641 0.3754
Schistosoma mansoni ets-related 0.0503 0.5372 0.5539
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.004 0.0246 0.0246
Echinococcus granulosus heat shock protein 90 0.0104 0.0953 0.0982
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0185 0.185 0.1908
Plasmodium vivax ataxin-2 like protein, putative 0.0081 0.0694 0.2949
Echinococcus granulosus neuropeptide s receptor 0.0525 0.5617 0.5792
Schistosoma mansoni hypothetical protein 0.0027 0.0095 0.0098
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0041 0.0253 0.07
Mycobacterium ulcerans two component sensor kinase MprB 0.0031 0.0144 0.0482
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0185 0.185 0.1908
Schistosoma mansoni elf1 0.0024 0.0068 0.007
Loa Loa (eye worm) TOPoisomerase family member 0.0181 0.1811 0.2447
Brugia malayi CXXC zinc finger family protein 0.0063 0.0497 0.0703
Echinococcus multilocularis ecdysone induced protein 78C 0.0185 0.185 0.185
Brugia malayi Smad1 0.0019 0.0008 0.0011
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0095 0.0857 0.238
Loa Loa (eye worm) hypothetical protein 0.0023 0.0053 0.0071
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.0046 0.0311 0.1321
Toxoplasma gondii peptidylprolyl isomerase 0.0067 0.0547 0.2321
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0036 0.0202 0.0202
Trichomonas vaginalis CAMK family protein kinase 0.0108 0.0992 0.333
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0048 0.0336 0.0931
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0095 0.0403
Loa Loa (eye worm) hypothetical protein 0.0025 0.0073 0.0099
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.001
Leishmania major heat shock protein 83-1 0.0135 0.1295 0.3538
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0266 0.0738
Trypanosoma cruzi DNA topoisomerase II, putative 0.0173 0.1716 0.4765
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0028 0.0029
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0042 0.0267 0.0654
Onchocerca volvulus Serine\/threonine kinase homolog 0.0217 0.2201 0.373
Schistosoma mansoni smad1 5 8 and 0.0019 0.0008 0.0008
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0052 0.038 0.038
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0087 0.0768 0.0792
Trypanosoma cruzi DNA polymerase eta, putative 0.0068 0.0551 0.153
Echinococcus granulosus lysine specific demethylase 5A 0.0103 0.0937 0.0966
Brugia malayi DKFZp564C0469 protein 0.0018 0.0001 0.0001
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.004 0.0239 0.0662
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0036 0.0202 0.0208
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.004 0.0239 0.08
Brugia malayi MH2 domain containing protein 0.0019 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.0185 0.185 0.2501
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0031 0.0144 0.0399
Trypanosoma cruzi DNA polymerase eta, putative 0.0153 0.1495 0.4151
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0098 0.0884 0.1195
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0267 0.0275
Echinococcus multilocularis neuropeptide receptor A26 0.0525 0.5617 0.5617
Schistosoma mansoni microtubule-associated protein tau 0.0784 0.848 0.8743
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0038 0.0217 0.117
Brugia malayi hypothetical protein 0.024 0.246 0.3482
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0108 0.1001 1
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.0046 0.0311 0.1321
Giardia lamblia Flap structure-specific endonuclease 0.0057 0.0437 0.1981
Brugia malayi WGR domain containing protein 0.0174 0.1723 0.2439
Trichomonas vaginalis hypothetical protein 0.0039 0.0234 0.0783
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0152 0.1484 0.1484
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0199 0.2008 0.2008
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0217 0.2201 0.2975
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0087 0.0768 0.0792
Schistosoma mansoni DNA helicase recq5 0.0052 0.038 0.0391
Trypanosoma cruzi heat shock protein 90, putative 0.0104 0.0953 0.2646
Echinococcus multilocularis lysine specific demethylase 5A 0.0099 0.0897 0.0897
Echinococcus granulosus jumonji domain containing 1A 0.0026 0.0094 0.0097
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0118 0.0121
Echinococcus granulosus lamin b receptor 0.0071 0.0582 0.06
Loa Loa (eye worm) ets-domain-containing protein 0.0024 0.0068 0.0092
Mycobacterium ulcerans putative regulatory protein 0.0092 0.082 0.2753
Echinococcus granulosus endoplasmin 0.0108 0.1001 0.1033
Echinococcus multilocularis microtubule associated protein 2 0.0784 0.848 0.848
Loa Loa (eye worm) hypothetical protein 0.0059 0.0453 0.0612
Trichomonas vaginalis replication factor C large subunit, putative 0.0018 0.0001 0.0000011741
Loa Loa (eye worm) hypothetical protein 0.017 0.168 0.2271
Loa Loa (eye worm) poly(ADP-ribose) polymerase 0.0068 0.0559 0.0755
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0077 0.0122
Schistosoma mansoni tsg101-related 0.0055 0.0405 0.0418
Toxoplasma gondii histone lysine methyltransferase SET1 0.012 0.1129 0.4798
Schistosoma mansoni gabp alpha 0.0166 0.1637 0.1687
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.0046 0.0311 0.0311
Trypanosoma cruzi polo-like protein kinase, putative 0.0217 0.2201 0.6113
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0226 0.0627
Leishmania major protein kinase, putative 0.0041 0.0253 0.0614
Entamoeba histolytica recQ family DNA helicase 0.0027 0.0096 0.0434
Mycobacterium leprae Possible regulatory protein 0.004 0.0239 0.2382
Brugia malayi nuclear hormone receptor family member nhr-6 0.0087 0.0768 0.1087
Chlamydia trachomatis DNA gyrase subunit B 0.0096 0.0862 0.8002
Loa Loa (eye worm) hypothetical protein 0.0185 0.185 0.2501
Loa Loa (eye worm) hypothetical protein 0.0087 0.0768 0.1038
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0042 0.0267 0.1209
Schistosoma mansoni smad1 5 8 and 0.0019 0.0008 0.0008
Echinococcus granulosus jumonji domain containing protein 0.0037 0.0211 0.0217
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0059 0.045 0.1168
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0055 0.0408 0.0578
Trichomonas vaginalis heat shock protein, putative 0.0108 0.1001 0.3361
Mycobacterium ulcerans hypothetical protein 0.0181 0.1802 0.605
Brugia malayi Muscleblind-like protein 0.017 0.168 0.2378
Echinococcus multilocularis ETS transcription factor Elf 1 0.0024 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0104
Toxoplasma gondii heat shock protein HSP90 0.0135 0.1295 0.5505
Brugia malayi hypoxia-induced factor 1 0.0171 0.1695 0.2399
Schistosoma mansoni retinoic acid receptor RXR 0.0297 0.309 0.3186
Brugia malayi polk-prov protein 0.0151 0.1477 0.209
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0052 0.038 0.1611
Brugia malayi Inositol-1 0.0042 0.0266 0.0377
Trypanosoma brucei DNA polymerase kappa, putative 0.0113 0.1055 0.293
Brugia malayi ecdysteroid receptor 0.0185 0.185 0.2619
Trypanosoma cruzi heat shock protein 90, putative 0.0074 0.0621 0.1722
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0087 0.0768 0.0792
Trichomonas vaginalis CAMK family protein kinase 0.0217 0.2201 0.7388
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0038 0.0052
Chlamydia trachomatis DNA gyrase subunit A 0.0034 0.018 0.1662
Plasmodium vivax DNA topoisomerase II, putative 0.0181 0.1811 0.7695
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0031 0.0144 0.0761
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0118 0.0121
Echinococcus granulosus microtubule associated protein 2 0.0784 0.848 0.8743
Trypanosoma brucei protein kinase, putative 0.0059 0.045 0.1249
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0118 0.0121
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0031 0.0144 0.0482
Loa Loa (eye worm) isocitrate dehydrogenase 0.0036 0.0202 0.0273
Schistosoma mansoni hypothetical protein 0.0055 0.0408 0.0421
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0075 0.0632 0.0854
Onchocerca volvulus 0.0087 0.0768 0.1301
Schistosoma mansoni topbp1 0.0018 0.0001 0.0001
Trypanosoma cruzi DNA damage repair protein, putative 0.0038 0.0226 0.0627
Brugia malayi Niemann-Pick C1 protein precursor 0.0112 0.104 0.1472
Plasmodium falciparum phd finger protein, putative 0.0027 0.0095 0.0403
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0134 0.1287 0.1327
Brugia malayi nuclear receptor NHR-88 0.0185 0.185 0.2619
Schistosoma mansoni hypothetical protein 0.0046 0.0314 0.0324
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0185 0.185 0.1908
Toxoplasma gondii exonuclease III APE 0.0021 0.0038 0.0159
Brugia malayi Pax transcription factor protein 2 0.0551 0.59 0.835
Entamoeba histolytica hypothetical protein 0.0152 0.1484 0.674
Schistosoma mansoni DNA helicase recq1 0.0052 0.038 0.0391
Trypanosoma brucei developmentally regulated phosphoprotein 0.0031 0.0144 0.0399
Trypanosoma cruzi C-14 sterol reductase, putative 0.0071 0.0582 0.1616
Loa Loa (eye worm) CXXC zinc finger family protein 0.0063 0.0497 0.0671
Trypanosoma brucei heat shock protein, putative 0.0135 0.1295 0.3597
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0046 0.0311 0.0441
Echinococcus granulosus dna polymerase eta 0.0153 0.1495 0.1541
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0059 0.0456 0.1935
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0104 0.0953 0.0982
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0018 0.0001 0.0000011741
Mycobacterium tuberculosis Conserved protein 0.0031 0.0144 0.0761
Echinococcus granulosus WGR domain containing protein 0.0054 0.0399 0.0411
Trichomonas vaginalis CAMK family protein kinase 0.0217 0.2201 0.7388
Trichomonas vaginalis endoplasmin, putative 0.0092 0.0819 0.2748
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0026 0.0094 0.0097
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0059 0.045 0.0609
Loa Loa (eye worm) STAT protein 0.0149 0.1456 0.1968
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0019 0.0008 0.0008
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0086 0.075 0.3188
Trypanosoma cruzi transcription factor btf3, putative 0.004 0.0241 0.0669
Loa Loa (eye worm) hypothetical protein 0.0098 0.0884 0.1195
Onchocerca volvulus 0.0217 0.2204 0.3736
Trypanosoma cruzi Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.0023 0.0053 0.0144
Brugia malayi nuclear hormone receptor 0.0185 0.185 0.2619
Echinococcus multilocularis FTZ F1 alpha 0.0185 0.185 0.185
Leishmania major heat shock protein, putative 0.0065 0.0525 0.1378
Trypanosoma brucei DNA polymerase kappa, putative 0.0237 0.242 0.6723
Plasmodium falciparum heat shock protein 90, putative 0.023 0.2353 1
Onchocerca volvulus 0.0063 0.0497 0.0841
Echinococcus multilocularis nuclear receptor nhr 48 0.0087 0.0768 0.0768
Leishmania major heat shock protein 83-1 0.0135 0.1295 0.3538
Entamoeba histolytica poly(ADP-ribose) polymerase, putative 0.0174 0.1723 0.7829
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.006 0.0467 0.1983
Echinococcus multilocularis inositol monophosphatase 1 0.0042 0.0266 0.0266
Echinococcus multilocularis jun protein 0.0269 0.2785 0.2785
Echinococcus multilocularis dna polymerase kappa 0.0237 0.242 0.242
Loa Loa (eye worm) hypothetical protein 0.0087 0.0768 0.1038
Leishmania major sterol C-24 reductase, putative 0.0071 0.0582 0.1539
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0077 0.0257
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.0429 0.0579
Loa Loa (eye worm) hypothetical protein 0.0131 0.1255 0.1696
Echinococcus granulosus tumor protein p63 0.0384 0.4051 0.4177
Brugia malayi Pax transcription activation domain interacting protein 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Brugia malayi jmjC domain containing protein 0.0026 0.0094 0.0133
Echinococcus multilocularis tumor protein p63 0.0384 0.4051 0.4051
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0036 0.0202 0.0559
Trypanosoma brucei heat shock protein 90, putative 0.0135 0.1295 0.3597
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0267 0.0893
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0031 0.0144 0.0482
Schistosoma mansoni cellular tumor antigen P53 0.0056 0.0424 0.0437
Brugia malayi Flap endonuclease-1 0.0057 0.0437 0.0618
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0114 0.1059 0.1092
Leishmania major developmentally regulated phosphoprotein-like protein 0.0031 0.0144 0.031
Echinococcus granulosus JmjC domain containing protein 4 0.0026 0.0094 0.0097
Loa Loa (eye worm) ICD-1 protein 0.004 0.0241 0.0326
Loa Loa (eye worm) RecQ helicase 0.0094 0.0847 0.1145
Trichomonas vaginalis heat shock protein, putative 0.0108 0.1001 0.3361
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0024 0.0068 0.007
Leishmania major heat shock protein 83-1 0.0135 0.1295 0.3538
Brugia malayi jmjC domain containing protein 0.0026 0.0094 0.0133
Trypanosoma cruzi heat shock protein 85, putative 0.0135 0.1295 0.3597
Loa Loa (eye worm) hypothetical protein 0.0087 0.0768 0.1038
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0124 0.117 0.1206
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0059 0.045 0.1168
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0185 0.185 0.1908
Onchocerca volvulus 0.0056 0.0424 0.0717
Brugia malayi orphan nuclear receptor NR2E1 0.0087 0.0768 0.1087
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0021 0.0034 0.0091
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0061 0.0476 0.1321
Brugia malayi topoisomerase 0.0018 0.0001 0.0001
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0036 0.0202 0.0856
Brugia malayi Intermediate filament tail domain containing protein 0.0025 0.0073 0.0104
Trypanosoma brucei C-14 sterol reductase, putative 0.0071 0.0582 0.1616
Onchocerca volvulus 0.0187 0.1871 0.3171
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0052 0.038 0.0537
Trypanosoma brucei chrX additional, unordered contigs 0.0038 0.0226 0.0627
Loa Loa (eye worm) flap endonuclease-1 0.0057 0.0437 0.059
Trypanosoma cruzi heat shock protein 85, putative 0.0135 0.1295 0.3597
Brugia malayi Probable DNA topoisomerase II 0.0181 0.1811 0.2562
Loa Loa (eye worm) hypothetical protein 0.0656 0.7066 0.955
Brugia malayi nuclear receptor RXR 0.0098 0.0884 0.1251
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0162 0.1599 0.439
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0075 0.0632 0.0632
Echinococcus granulosus poly (ADP ribose) polymerase 0.0027 0.01 0.0103
Entamoeba histolytica DNA topoisomerase II, putative 0.0181 0.1811 0.8226
Loa Loa (eye worm) hypothetical protein 0.0185 0.185 0.2501
Echinococcus multilocularis survival motor neuron protein 1 0.0269 0.2776 0.2776
Brugia malayi bHLH-PAS transcription factor 0.0092 0.082 0.1161
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.003 0.0133 0.0133
Mycobacterium ulcerans glutaminase 0.0287 0.2979 1
Trichomonas vaginalis adenylate cyclase, putative 0.004 0.0239 0.08
Trichomonas vaginalis glutaminase, putative 0.0287 0.2979 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0094 0.0847 0.2843
Echinococcus multilocularis muscleblind protein 1 0.017 0.168 0.168
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0042 0.0266 0.1207
Trypanosoma cruzi DNA topoisomerase II, putative 0.0173 0.1716 0.4765
Trichomonas vaginalis heat shock protein, putative 0.0135 0.1295 0.4348
Schistosoma mansoni pyruvate dehydrogenase 0.0031 0.0144 0.0149
Trichomonas vaginalis heat shock protein, putative 0.0104 0.0953 0.3198
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0036 0.0202 0.1083
Schistosoma mansoni ets 0.0024 0.0068 0.007
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0108 0.1001 0.9293
Echinococcus multilocularis mothers against decapentaplegic 5 0.0019 0.0008 0.0008
Echinococcus granulosus smad 0.0019 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0027 0.0096 0.013
Schistosoma mansoni hypothetical protein 0.0101 0.0924 0.0953
Entamoeba histolytica hypothetical protein 0.0152 0.1484 0.674
Giardia lamblia DNA damage repair protein 0.0038 0.0226 0.1025
Brugia malayi F/Y-rich N-terminus family protein 0.0029 0.0121 0.0171
Echinococcus granulosus GA binding protein alpha chain 0.0166 0.1637 0.1687
Schistosoma mansoni smad1 5 8 and 0.0019 0.0008 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0185 0.185 0.2619
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0185 0.185 0.2619
Loa Loa (eye worm) hypothetical protein 0.0087 0.0768 0.1038
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0026 0.0094 0.0259
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0077 0.0348
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0027 0.0095 0.0098
Brugia malayi hypothetical protein 0.0269 0.2776 0.3928
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0124 0.117 0.117
Loa Loa (eye worm) hypothetical protein 0.0185 0.185 0.2501
Entamoeba histolytica serine/threonine protein kinase, putative 0.0217 0.2201 1
Echinococcus multilocularis poly (ADP ribose) polymerase 0.004 0.0243 0.0243
Schistosoma mansoni coup transcription factor 0.0185 0.185 0.1908
Brugia malayi PHD-finger family protein 0.0027 0.0095 0.0135
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0185 0.185 0.2501
Mycobacterium leprae Probable two component sensor kinase MprB 0.0031 0.0144 0.1434
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0031 0.0144 0.0761
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0237 0.242 0.8126
Loa Loa (eye worm) inositol-1 0.0042 0.0266 0.036
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0018 0.0001 0.0000011741
Loa Loa (eye worm) hypothetical protein 0.0098 0.0884 0.1195
Echinococcus multilocularis transcription factor Dp 1 0.0043 0.0282 0.0282
Echinococcus granulosus ubiquitin specific protease 41 0.0042 0.0267 0.0275
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0038 0.0159
Echinococcus granulosus dna polymerase kappa 0.0237 0.242 0.2495
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0267 0.0267
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0267 0.0893
Onchocerca volvulus DNA ligase 3 homolog 0.0023 0.0053 0.0088
Mycobacterium tuberculosis Probable DNA polymerase IV DinX (pol IV 1) (DNA nucleotidyltransferase (DNA-directed)) 0.0028 0.0112 0.0582
Leishmania major DNA damage repair protein, putative 0.0038 0.0226 0.054
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0018 0.0001 0.0001
Loa Loa (eye worm) intermediate filament protein 0.0025 0.0073 0.0099
Leishmania major DNA repair protein, putative 0.0023 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0185 0.185 0.2501
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0031 0.0144 0.0761
Echinococcus multilocularis jumonji domain containing 1A 0.0026 0.0094 0.0094
Loa Loa (eye worm) hypothetical protein 0.0048 0.0333 0.045
Loa Loa (eye worm) hypothetical protein 0.0107 0.0991 0.134
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.045 0.151
Echinococcus granulosus single minded 2 0.0092 0.082 0.0846
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0154 0.1504 0.1504
Trypanosoma brucei poly(adp-ribose) polymerase 0.0095 0.0857 0.238
Loa Loa (eye worm) hypothetical protein 0.0087 0.0768 0.1038
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.0632 0.1754
Echinococcus multilocularis ets variant gene 4 0.0024 0.0068 0.0068
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0185 0.185 0.2501
Schistosoma mansoni jumonji/arid domain-containing protein 0.0103 0.0937 0.0966
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0031 0.0144 0.0482
Echinococcus multilocularis dnaJ subfamily B 0.0894 0.9699 0.9699
Echinococcus granulosus transcription factor btf3 0.004 0.0241 0.0249
Trypanosoma brucei transcription factor BTF3, putative 0.004 0.0241 0.0669
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0077 0.0257
Entamoeba histolytica hypothetical protein 0.0027 0.01 0.0452
Trypanosoma brucei DNA damage repair protein, putative 0.0038 0.0226 0.0627
Schistosoma mansoni jumonji domain containing protein 0.0136 0.1306 0.1346
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0031 0.0144 0.0761
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0025 0.0073 0.0099
Plasmodium vivax heat shock protein 86, putative 0.0135 0.1295 0.5505
Schistosoma mansoni nuclear hormone receptor 0.0087 0.0768 0.0792
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0038 0.0038
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0067 0.0547 0.1438
Brugia malayi glutaminase DH11.1 0.0287 0.2979 0.4215
Brugia malayi DNA-binding protein D-ETS-3 0.0024 0.0068 0.0096
Onchocerca volvulus Bile acid receptor homolog 0.0185 0.185 0.3136
Leishmania major heat shock protein 83-1 0.0135 0.1295 0.3538
Echinococcus granulosus PHD finger protein rhinoceros 0.0027 0.0095 0.0098
Echinococcus multilocularis heat shock protein 0.0135 0.1295 0.1295
Loa Loa (eye worm) jmjC domain-containing protein 0.0026 0.0094 0.0127
Echinococcus granulosus ETS transcription factor Elf 1 0.0024 0.0068 0.007
Loa Loa (eye worm) hypothetical protein 0.0098 0.0884 0.1195
Onchocerca volvulus Alhambra homolog 0.0027 0.0095 0.0161
Leishmania major heat shock protein 83-1 0.0135 0.1295 0.3538
Toxoplasma gondii heat shock protein 75, putative 0.0065 0.0525 0.223
Echinococcus granulosus jun protein 0.0269 0.2785 0.2872
Echinococcus granulosus ETS domain containing protein Elk 1 0.0024 0.0068 0.007
Loa Loa (eye worm) hypothetical protein 0.0063 0.0503 0.0679
Loa Loa (eye worm) glutaminase 0.0287 0.2979 0.4026
Loa Loa (eye worm) TAR-binding protein 0.0072 0.0598 0.0809
Trypanosoma cruzi polo-like protein kinase, putative 0.0217 0.2201 0.6113
Echinococcus granulosus poly ADP ribose polymerase 1 0.0174 0.1723 0.1777
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0048 0.0336 0.0931
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0026 0.0094 0.0396
Schistosoma mansoni tsg101-related 0.0067 0.0541 0.0557
Leishmania major hypothetical protein, conserved 0.0026 0.0094 0.0169
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0185 0.185 0.2501
Schistosoma mansoni hypothetical protein 0.0258 0.2654 0.2736
Brugia malayi Isocitrate dehydrogenase 0.0036 0.0202 0.0286
Echinococcus multilocularis smad 0.0019 0.0008 0.0008
Brugia malayi Bromodomain containing protein 0.0027 0.0095 0.0135
Echinococcus multilocularis neuropeptide s receptor 0.0525 0.5617 0.5617
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0031 0.0144 0.0761
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0118 0.0121
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0166 0.1637 0.2212
Loa Loa (eye worm) hypothetical protein 0.0056 0.0424 0.0573
Loa Loa (eye worm) PHD-finger family protein 0.0027 0.0095 0.0129
Schistosoma mansoni zinc finger protein 0.0087 0.0768 0.0792
Echinococcus multilocularis Niemann Pick C1 protein 0.016 0.1571 0.1571
Trichomonas vaginalis heat shock protein, putative 0.0061 0.0477 0.1598
Plasmodium falciparum DNA repair protein REV1, putative 0.0038 0.0226 0.0959
Toxoplasma gondii LsmAD domain-containing protein 0.0081 0.0694 0.2949
Schistosoma mansoni DNA polymerase eta 0.0153 0.1495 0.1541
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.001
Schistosoma mansoni ap endonuclease 0.0021 0.0038 0.0039
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0031 0.0144 0.0144
Trypanosoma cruzi C-14 sterol reductase, putative 0.0071 0.0582 0.1616
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0031 0.0144 0.0761
Brugia malayi STAT protein, DNA binding domain containing protein 0.0149 0.1456 0.206
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0038 0.0104
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0052 0.038 0.0391
Plasmodium falciparum basic transcription factor 3b, putative 0.004 0.0241 0.1023
Brugia malayi nuclear receptor NHR-88 0.0087 0.0768 0.1087
Trichomonas vaginalis guanylate cyclase, putative 0.004 0.0239 0.08
Brugia malayi Fli-1 protein 0.0503 0.5372 0.7603
Brugia malayi kinase, mitochondrial precursor 0.0031 0.0144 0.0204
Mycobacterium ulcerans two component regulator - sensor kinase 0.0031 0.0144 0.0482
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0066 0.0537 0.2278
Echinococcus granulosus TGF beta signal transducer SmadC 0.0019 0.0008 0.0008
Echinococcus granulosus flap endonuclease 1 0.0057 0.0437 0.045
Trypanosoma cruzi heat shock protein 85, putative 0.0104 0.0953 0.2646
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0059 0.045 0.1249
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0258 0.2654 0.2654
Echinococcus multilocularis geminin 0.0347 0.3641 0.3641
Trichomonas vaginalis DNA topoisomerase II, putative 0.0181 0.1811 0.6078
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0038 0.0104
Brugia malayi serine/threonine-protein kinase plk-2 0.0217 0.2201 0.3115
Loa Loa (eye worm) hypothetical protein 0.017 0.168 0.2271
Loa Loa (eye worm) jmjC domain-containing protein 0.0103 0.0937 0.1266
Loa Loa (eye worm) hypothetical protein 0.0042 0.0267 0.036
Trypanosoma brucei unspecified product 0.0085 0.0745 0.2068
Schistosoma mansoni glutaminase 0.0287 0.2979 0.3071
Brugia malayi WGR domain containing protein 0.0095 0.0857 0.1213
Echinococcus multilocularis lysine specific demethylase 6a 0.0026 0.0094 0.0094
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.004 0.0239 0.08
Mycobacterium tuberculosis Possible two component sensor kinase 0.0031 0.0144 0.0761
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0042 0.0266 0.2465
Schistosoma mansoni chromosome transmission fidelity factor 0.0018 0.0001 0.0001
Brugia malayi steroid hormone receptor 0.0185 0.185 0.2619
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0185 0.185 0.1908
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0077 0.0257
Loa Loa (eye worm) hypothetical protein 0.0147 0.1434 0.1938
Giardia lamblia DINP protein human, muc B family 0.0152 0.148 0.6723
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0185 0.185 0.185
Brugia malayi N-terminal motif family protein 0.0205 0.2072 0.2932
Schistosoma mansoni steroid hormone receptor ad4bp 0.0185 0.185 0.1908
Trypanosoma cruzi Heat shock protein 83, putative 0.0135 0.1295 0.3597
Plasmodium vivax basic transcription factor 3b, putative 0.004 0.0241 0.1023
Plasmodium vivax heat shock protein, putative 0.023 0.2353 1
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0147 0.1434 0.2029
Trichomonas vaginalis receptor histidine kinase, putative 0.0031 0.0144 0.0482
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0082 0.0715 0.0737
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0181 0.1811 0.2562
Echinococcus multilocularis nibrin 0.0018 0.0001 0.0001
Echinococcus multilocularis mitogen activated protein kinase 0.0059 0.045 0.045
Toxoplasma gondii isocitrate dehydrogenase 0.0036 0.0202 0.0856
Trichomonas vaginalis guanylate cyclase, putative 0.004 0.0239 0.08
Loa Loa (eye worm) hypothetical protein 0.0087 0.0768 0.1038
Echinococcus granulosus poly (ADP ribose) polymerase 0.0027 0.01 0.0103
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0115 0.1078 1
Echinococcus granulosus bloom syndrome protein 0.0094 0.0847 0.0873
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0021 0.0034 0.0091
Brugia malayi Nuclear hormone receptor-like 1 0.0098 0.0884 0.1251
Trypanosoma cruzi heat shock protein 90, putative 0.0135 0.1295 0.3597
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0041 0.0253 0.07
Leishmania major heat shock protein 83-1 0.0135 0.1295 0.3538
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0024 0.0068 0.0092
Brugia malayi hypothetical protein 0.0098 0.0884 0.1251
Chlamydia trachomatis DNA gyrase subunit A 0.0034 0.018 0.1662
Plasmodium falciparum flap endonuclease 1 0.0057 0.0437 0.1853
Schistosoma mansoni inositol monophosphatase 0.0042 0.0266 0.0274
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0181 0.1811 0.1867
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0185 0.185 0.2619
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0124 0.117 0.1206
Echinococcus granulosus lamin dm0 0.0025 0.0073 0.0076
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0059 0.0453 0.1255
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0098 0.0884 0.0884
Echinococcus granulosus ETS transcription factor Elf 2 0.0024 0.0068 0.007
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0036 0.0202 0.0856
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0118 0.0118
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0087 0.0768 0.1087
Plasmodium falciparum heat shock protein 90 0.0135 0.1295 0.5505
Loa Loa (eye worm) hypothetical protein 0.0022 0.0043 0.0058
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.004 0.0239 0.08
Brugia malayi intermediate filament protein 0.0025 0.0073 0.0104
Loa Loa (eye worm) DR-78 0.0087 0.0768 0.1038
Echinococcus granulosus nibrin 0.0018 0.0001 0.0001
Schistosoma mansoni phosphatidylserine receptor 0.0026 0.0094 0.0097
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.013 0.1241 0.2102
Brugia malayi PAS domain containing protein 0.0132 0.1258 0.178
Loa Loa (eye worm) heat shock protein 75 0.0065 0.0525 0.071
Echinococcus granulosus replication factor c subunit 1 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0185 0.185 0.2501
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0077 0.0109
Brugia malayi hypothetical protein 0.0227 0.2318 0.3281
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0042 0.0266 0.0892
Brugia malayi jmjC domain containing protein 0.0026 0.0094 0.0133
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0104
Loa Loa (eye worm) hypothetical protein 0.0098 0.0884 0.1195
Loa Loa (eye worm) hypothetical protein 0.0052 0.038 0.0513
Giardia lamblia Kinase, PLK 0.0217 0.2201 1
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0031 0.0144 0.0482
Mycobacterium tuberculosis Conserved hypothetical protein 0.0124 0.117 0.6475
Loa Loa (eye worm) endoplasmin 0.0135 0.1295 0.1751
Schistosoma mansoni endoplasmin 0.0135 0.1295 0.1336
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0226 0.0627
Trichomonas vaginalis rotamase, putative 0.0067 0.0547 0.1833
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0115 0.1078 1
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0267 0.0275
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0008 0.0029
Schistosoma mansoni eyes absent homolog 0.0092 0.0826 0.0851
Trypanosoma brucei heat shock protein, putative 0.0135 0.1295 0.3597
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0266 0.0652
Trypanosoma brucei Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.0023 0.0053 0.0144
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0343 0.36 1
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0205 0.2072 0.3511
Schistosoma mansoni phd/f-box containing protein 0.0026 0.0094 0.0097
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0077 0.0257
Brugia malayi heat shock protein 90 0.0135 0.1295 0.1833
Echinococcus multilocularis aryl hydrocarbon receptor 0.0187 0.1878 0.1878
Loa Loa (eye worm) jmjC domain-containing protein 0.0026 0.0094 0.0127
Echinococcus multilocularis lamin 0.0025 0.0073 0.0073
Echinococcus granulosus Nuclear hormone receptor HR96 0.0087 0.0768 0.0792
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0057 0.0437 0.1211
Trypanosoma brucei DNA polymerase eta, putative 0.0153 0.1495 0.4151
Loa Loa (eye worm) hypothetical protein 0.017 0.1686 0.2278
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0112 0.104 0.4723
Loa Loa (eye worm) heat shock protein 90 0.0135 0.1295 0.1751
Giardia lamblia Heat shock protein HSP 90-alpha 0.0135 0.1295 0.5885
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0036 0.0202 0.0559
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0065 0.0525 0.2384
Leishmania major heat shock protein 83-1 0.0135 0.1295 0.3538
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0098 0.0884 0.0911
Trypanosoma brucei heat shock protein, putative 0.0135 0.1295 0.3597
Loa Loa (eye worm) hypothetical protein 0.0132 0.1264 0.1709
Schistosoma mansoni nuclear receptor 0.0087 0.0768 0.0792
Echinococcus multilocularis expressed conserved protein 0.0105 0.0965 0.0965
Brugia malayi hypothetical protein 0.0087 0.0768 0.1087
Echinococcus granulosus aryl hydrocarbon receptor 0.0187 0.1878 0.1936
Giardia lamblia Pms1-like protein 0.0031 0.0144 0.0652
Brugia malayi hypothetical protein 0.0052 0.0378 0.0535
Echinococcus multilocularis ubiquitin specific protease 41 0.0042 0.0267 0.0267
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0031 0.0144 0.0482
Echinococcus granulosus mitogen activated protein kinase 3 0.0059 0.045 0.0464
Schistosoma mansoni kinase 0.011 0.1024 0.1056
Trypanosoma brucei DNA polymerase kappa, putative 0.0237 0.242 0.6723
Brugia malayi TAR-binding protein 0.0072 0.0598 0.0847
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0077 0.0764
Trypanosoma brucei unspecified product 0.0085 0.0745 0.2068
Trichomonas vaginalis DNA helicase recq, putative 0.0094 0.0847 0.2843
Trichomonas vaginalis set domain proteins, putative 0.0217 0.2204 0.7401
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0038 0.0104
Echinococcus multilocularis replication factor c subunit 1 0.0018 0.0001 0.0001
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0185 0.185 0.185
Plasmodium vivax DNA repair protein REV1, putative 0.0038 0.0226 0.0959
Echinococcus granulosus Smad4 0.0019 0.0008 0.0008
Trypanosoma brucei heat shock protein, putative 0.0135 0.1295 0.3597
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0269 0.2785 0.2872
Loa Loa (eye worm) hypothetical protein 0.0205 0.2072 0.2801
Trichomonas vaginalis flap endonuclease-1, putative 0.0057 0.0437 0.1464
Trypanosoma brucei Heat shock protein 83, putative 0.0135 0.1295 0.3597
Brugia malayi nuclear receptor RXR 0.0087 0.0768 0.1087
Leishmania major mitochondrial DNA topoisomerase II 0.0201 0.2026 0.5586
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0026 0.0094 0.0396
Loa Loa (eye worm) hypothetical protein 0.024 0.246 0.3325
Echinococcus granulosus dnaJ subfamily B 0.0894 0.9699 1
Leishmania major heat shock protein 83-1 0.0135 0.1295 0.3538
Schistosoma mansoni topbp1 0.0018 0.0001 0.0001
Trypanosoma brucei heat shock protein, putative 0.0135 0.1295 0.3597
Schistosoma mansoni single-minded 0.0132 0.1258 0.1297
Loa Loa (eye worm) D-ets-2 protein 0.0024 0.0068 0.0092
Toxoplasma gondii hypothetical protein 0.0055 0.0414 0.1758
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0038 0.0217 0.2166
Loa Loa (eye worm) hypothetical protein 0.0087 0.0768 0.1038
Brugia malayi Ets-domain containing protein 0.0166 0.1637 0.2316
Echinococcus granulosus neuropeptide receptor A26 0.0525 0.5617 0.5792
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0031 0.0144 0.0149
Schistosoma mansoni inositol monophosphatase 0.0042 0.0266 0.0274
Schistosoma mansoni blooms syndrome DNA helicase 0.0068 0.0553 0.057
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0297 0.309 0.3186
Schistosoma mansoni hypothetical protein 0.0039 0.023 0.0237
Schistosoma mansoni tsg101-related 0.0067 0.0541 0.0557
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0185 0.185 0.1908
Trypanosoma brucei DNA polymerase kappa, putative 0.0237 0.242 0.6723
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0077 0.0257
Loa Loa (eye worm) glutaminase 2 0.0287 0.2979 0.4026
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0059 0.045 0.1249
Loa Loa (eye worm) hypothetical protein 0.0092 0.0826 0.1116
Schistosoma mansoni patched 1 0.0048 0.0333 0.0343
Schistosoma mansoni hypothetical protein 0.0024 0.0068 0.007
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0069 0.0565 0.0799
Schistosoma mansoni terminal deoxycytidyl transferase 0.0124 0.117 0.1206
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.023 0.0326
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0267 0.0893
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0201 0.2026 0.5626
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0075 0.0632 0.0651
Trypanosoma cruzi transcription factor btf3, putative 0.004 0.0241 0.0669
Trichomonas vaginalis CAMK family protein kinase 0.0217 0.2201 0.7388
Schistosoma mansoni hypothetical protein 0.0219 0.2226 0.2295
Trypanosoma brucei unspecified product 0.0208 0.211 0.5861
Toxoplasma gondii DNA topoisomerase 2, putative 0.0181 0.1811 0.7695
Loa Loa (eye worm) hypothetical protein 0.0153 0.1495 0.202
Entamoeba histolytica heat shock protein 90, putative 0.0135 0.1295 0.5885
Echinococcus granulosus Protein patched homolog 1 0.0048 0.0333 0.0343
Schistosoma mansoni thyroid hormone receptor 0.0443 0.4703 0.4848
Echinococcus multilocularis ETS transcription factor Elf 2 0.0024 0.0068 0.0068
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0052 0.038 0.0513
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0185 0.185 0.185
Brugia malayi MAP kinase sur-1 0.0059 0.045 0.0637
Loa Loa (eye worm) hypoxia-induced factor 1 0.0171 0.1695 0.2291
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0185 0.185 0.185
Toxoplasma gondii NAC domain-containing protein 0.004 0.0241 0.1023
Loa Loa (eye worm) jmjC domain-containing protein 0.0026 0.0094 0.0127
Toxoplasma gondii heat shock protein 90, putative 0.0135 0.1295 0.5505
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0034 0.018 0.0959
Trichomonas vaginalis heat shock protein, putative 0.0092 0.0819 0.2748
Loa Loa (eye worm) hypothetical protein 0.0087 0.0768 0.1038
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0052 0.038 0.1611
Leishmania major heat shock protein 83-1 0.0135 0.1295 0.3538
Schistosoma mansoni RAR-like nuclear receptor 0.0185 0.185 0.1908
Brugia malayi hypothetical protein 0.0212 0.2145 0.3035
Toxoplasma gondii DNA gyrase/topoisomerase IV, A subunit domain-containing protein 0.0034 0.018 0.0761
Trypanosoma brucei heat shock protein 90, putative 0.0135 0.1295 0.3597
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0075 0.0632 0.0651
Trichomonas vaginalis sensor histidine kinase, putative 0.0031 0.0144 0.0482
Schistosoma mansoni intermediate filament proteins 0.0025 0.0073 0.0076
Echinococcus multilocularis thyroid hormone receptor alpha 0.0443 0.4703 0.4703
Brugia malayi RNA recognition motif domain containing protein 0.0072 0.0598 0.0847
Giardia lamblia Heat shock protein HSP 90-alpha 0.0104 0.0953 0.4328
Schistosoma mansoni DNA polymerase IV / kappa 0.0038 0.0226 0.0233
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.003 0.0133 0.0137
Brugia malayi MH2 domain containing protein 0.0019 0.0008 0.0011
Schistosoma mansoni jumonji domain containing protein 0.0026 0.0094 0.0097
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0031 0.0144 0.0761
Trypanosoma brucei PAB1-binding protein , putative 0.0081 0.0694 0.1927
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0057 0.0437 0.1211
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.001
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0031 0.0144 0.0482
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0061 0.0476 0.1321
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0026 0.0094 0.0259
Leishmania major DNA topoisomerase ii 0.0173 0.1716 0.4717
Trichomonas vaginalis DNA polymerase eta, putative 0.0237 0.242 0.8126
Loa Loa (eye worm) hypothetical protein 0.0262 0.2704 0.3654
Leishmania major DNA polymerase eta, putative 0.0153 0.1495 0.4097
Trichomonas vaginalis CAMK family protein kinase 0.0217 0.2201 0.7388
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0115 0.1078 0.4579
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0031 0.0144 0.0761
Schistosoma mansoni nuclear receptor nhr-48 0.0087 0.0768 0.0792
Entamoeba histolytica recQ family helicase, putative 0.0026 0.0085 0.0383
Echinococcus multilocularis poly (ADP ribose) polymerase 1 0.0174 0.1723 0.1723
Brugia malayi MH1 domain containing protein 0.0019 0.0008 0.0011
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0042 0.0267 0.0275
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0191 0.1915 0.2588
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0343 0.36 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0019 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0185 0.185 0.2501
Schistosoma mansoni DNA ligase IV 0.0018 0.0001 0.0001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0185 0.185 0.2501
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.0046 0.0311 0.1321
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0021 0.0034 0.0091
Loa Loa (eye worm) hypothetical protein 0.0087 0.0768 0.1038
Loa Loa (eye worm) hypothetical protein 0.0095 0.0857 0.1159
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0077 0.0348
Trichomonas vaginalis CAMK family protein kinase 0.0108 0.0992 0.333
Schistosoma mansoni lamin 0.0025 0.0073 0.0076
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0067 0.0547 0.1517
Onchocerca volvulus Huntingtin homolog 0.024 0.246 0.4169
Loa Loa (eye worm) MH1 domain-containing protein 0.0019 0.0008 0.001
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0115 0.1078 0.5963
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.001
Mycobacterium ulcerans DNA gyrase subunit A 0.0034 0.018 0.0601
Loa Loa (eye worm) hypothetical protein 0.0279 0.2887 0.3901
Toxoplasma gondii PHD-finger domain-containing protein 0.0027 0.0095 0.0403
Loa Loa (eye worm) hypothetical protein 0.0046 0.0311 0.0421
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.045 0.1249
Chlamydia trachomatis DNA gyrase subunit B 0.0115 0.1078 1
Schistosoma mansoni transcription factor LCR-F1 0.0152 0.1484 0.153
Loa Loa (eye worm) hypothetical protein 0.0107 0.0991 0.134
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0185 0.185 0.2619
Echinococcus multilocularis muscleblind protein 0.017 0.168 0.168
Echinococcus granulosus inositol monophosphatase 1 0.0042 0.0266 0.0274
Echinococcus granulosus thyroid hormone receptor alpha 0.0087 0.0768 0.0792
Schistosoma mansoni aryl hydrocarbon receptor 0.0263 0.2711 0.2795
Echinococcus multilocularis GA binding protein alpha chain 0.0166 0.1637 0.1637
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0041 0.0258 0.2575
Loa Loa (eye worm) Smad1 0.0019 0.0008 0.001
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0185 0.185 0.2619
Trichomonas vaginalis receptor histidine kinase, putative 0.0031 0.0144 0.0482
Trichomonas vaginalis inositol monophosphatase, putative 0.0042 0.0266 0.0892
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0239 0.08
Schistosoma mansoni hypothetical protein 0.0046 0.0314 0.0324
Echinococcus multilocularis musashi 0.0025 0.0073 0.0073
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0031 0.0144 0.1332
Brugia malayi tailless protein 0.0087 0.0768 0.1087
Leishmania major heat shock protein 83-1 0.0135 0.1295 0.3538
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.0632 0.1754
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0031 0.0144 0.061
Leishmania major mitochondrial DNA polymerase beta 0.0343 0.36 1
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.0021 0.0034 0.014
Trichomonas vaginalis rotamase, putative 0.0069 0.0565 0.1894
Onchocerca volvulus Protein ultraspiracle homolog 0.0185 0.185 0.3136
Trypanosoma brucei DNA polymerase IV, putative 0.0237 0.242 0.6723
Echinococcus multilocularis protein patched 0.0048 0.0333 0.0333
Echinococcus granulosus ETS transcription factor Elf 2 0.0024 0.0068 0.007
Schistosoma mansoni lamin 0.0025 0.0073 0.0076
Brugia malayi Nuclear hormone receptor-like 1 0.0098 0.0884 0.1251
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0057 0.0431 0.0583
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0041 0.0253 0.07
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0061 0.0476 0.1241
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0031 0.0144 0.0482
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0217 0.2201 0.6077
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0098 0.0884 0.0911
Loa Loa (eye worm) steroid hormone receptor 0.0185 0.185 0.2501
Echinococcus granulosus protein C ets 2 0.0024 0.0068 0.007
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0087 0.0768 0.0768
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0087 0.0768 0.0768
Loa Loa (eye worm) hypothetical protein 0.0269 0.2776 0.3751
Schistosoma mansoni endoplasmin 0.0135 0.1295 0.1336
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0108 0.1001 0.2714
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0042 0.0266 0.1129
Onchocerca volvulus 0.0087 0.0768 0.1301
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0266 0.0738
Treponema pallidum heat shock protein 90 0.0108 0.1001 0.9293
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0036 0.0202 0.0472
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0031 0.0144 0.1434
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0087 0.0768 0.1301
Leishmania major heat shock protein 83-1 0.0135 0.1295 0.3538
Loa Loa (eye worm) nuclear receptor NHR-67 0.0087 0.0768 0.1038
Loa Loa (eye worm) hypothetical protein 0.0024 0.0068 0.0092
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0154 0.1504 0.155
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0038 0.0348
Brugia malayi nuclear hormone receptor family member odr-7 0.0087 0.0768 0.1087
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0057 0.0437 0.1853
Brugia malayi Nuclear hormone receptor E75 0.0087 0.0768 0.1087
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0181 0.1811 0.2562
Giardia lamblia PHD finger protein 15 0.0027 0.0095 0.0431
Echinococcus granulosus tar DNA binding protein 0.0072 0.0598 0.0617
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0028 0.0028
Toxoplasma gondii PHD-finger domain-containing protein 0.0027 0.0095 0.0403
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0185 0.185 0.2501
Mycobacterium ulcerans DNA polymerase IV 0.0237 0.242 0.8126
Echinococcus granulosus ewsr:fli fusion protein type 0.0024 0.0068 0.007
Echinococcus granulosus Niemann Pick C1 protein 0.0112 0.104 0.1072
Echinococcus multilocularis dna polymerase eta 0.0153 0.1495 0.1495
Brugia malayi isocitrate dehydrogenase 0.0036 0.0202 0.0286
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0077 0.0764
Entamoeba histolytica heat shock protein 90, putative 0.0135 0.1295 0.5885
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.0429 0.0607
Loa Loa (eye worm) hypothetical protein 0.0024 0.0068 0.0093
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0036 0.0202 0.0202
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0087 0.0768 0.1038
Brugia malayi photoreceptor-specific nuclear receptor 0.0185 0.185 0.2619
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0031 0.0144 0.1332
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0162 0.1599 0.4441
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0267 0.0267
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0185 0.185 0.1908
Brugia malayi Endoplasmin precursor 0.0135 0.1295 0.1833
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0038 0.0054
Echinococcus multilocularis expressed protein 0.0069 0.0565 0.0565
Loa Loa (eye worm) hypothetical protein 0.0686 0.7399 1
Loa Loa (eye worm) hypothetical protein 0.008 0.0689 0.0931
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0098 0.0884 0.0911
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0046 0.0311 0.0441
Trypanosoma brucei DNA polymerase kappa, putative 0.0237 0.242 0.6723
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0031 0.0144 0.0761
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0027 0.0096 0.0265
Echinococcus multilocularis protein C ets 2 0.0024 0.0068 0.0068
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0185 0.185 0.2619
Echinococcus multilocularis jumonji domain containing protein 0.0037 0.0211 0.0211
Echinococcus multilocularis transcription factor btf3 0.004 0.0241 0.0241
Schistosoma mansoni hypothetical protein 0.0046 0.0314 0.0324
Loa Loa (eye worm) hypothetical protein 0.0227 0.2318 0.3133
Trypanosoma brucei DNA polymerase kappa, putative 0.0151 0.1477 0.4102
Loa Loa (eye worm) hypothetical protein 0.0142 0.137 0.1852
Trypanosoma brucei DNA polymerase kappa, putative 0.0113 0.1055 0.293
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0144 0.061
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0077 0.0388
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0067 0.0547 0.1517
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0038 0.017
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0031 0.0144 0.0482
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0185 0.185 0.2619
Trichomonas vaginalis CAMK family protein kinase 0.0217 0.2201 0.7388
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0048 0.0336 0.0931
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.004 0.0239 0.0662
Brugia malayi MH2 domain containing protein 0.0273 0.2827 0.4
Echinococcus multilocularis cpg binding protein 0.0066 0.0536 0.0536
Echinococcus multilocularis ETS transcription factor Elf 5 0.0024 0.0068 0.0068
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0173 0.1716 0.4765
Echinococcus multilocularis protein dispatched 1 0.0055 0.0408 0.0408
Schistosoma mansoni heat shock protein 0.0065 0.0525 0.0541
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0068 0.0551 0.2341
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.0429 0.0607
Loa Loa (eye worm) jmjC domain-containing protein 0.0055 0.0408 0.0552
Brugia malayi ImpB/MucB/SamB family protein 0.0124 0.117 0.1655
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0333 0.1116
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0269 0.2785 0.2785
Schistosoma mansoni nuclear receptor 0.0087 0.0768 0.0792
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0036 0.0202 0.0208
Wolbachia endosymbiont of Brugia malayi DNA gyrase subunit A 0.0034 0.018 0.1662
Plasmodium vivax DNA gyrase subunit A, putative 0.0034 0.018 0.0761
Brugia malayi transcription factor E74 isoform 0.0024 0.0068 0.0096
Brugia malayi bZIP transcription factor family protein 0.0269 0.2785 0.3942
Plasmodium vivax endoplasmin, putative 0.0135 0.1295 0.5505
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0087 0.0768 0.1301
Echinococcus granulosus intermediate filament protein 0.0025 0.0073 0.0076
Loa Loa (eye worm) hypothetical protein 0.0018 0.0001 0.0001
Brugia malayi Bloom's syndrome protein homolog 0.0094 0.0847 0.1199
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0031 0.0144 0.061
Trypanosoma brucei DNA polymerase kappa, putative 0.0237 0.242 0.6723
Entamoeba histolytica hypothetical protein 0.0152 0.1484 0.674
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0038 0.017
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0192 0.1922 0.817
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0185 0.185 0.2619
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.045 0.151
Onchocerca volvulus 0.0025 0.0073 0.0123
Leishmania major DNA polymerase kappa, putative 0.0038 0.0226 0.054
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0266 0.0892
Brugia malayi hypothetical protein 0.0098 0.0884 0.1251
Treponema pallidum ATP-dependent DNA helicase 0.0027 0.0096 0.0887
Loa Loa (eye worm) hypothetical protein 0.0022 0.0043 0.0058
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0266 0.0892
Echinococcus multilocularis ewsr:fli fusion protein type 0.0024 0.0068 0.0068
Leishmania major basic transcription factor 3a, putative 0.004 0.0241 0.0583
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0027 0.0096 0.0406
Brugia malayi ImpB/MucB/SamB family protein 0.0153 0.1495 0.2115
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0031 0.0144 0.0482
Plasmodium falciparum DNA gyrase subunit A 0.0034 0.018 0.0761
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0077 0.0348
Echinococcus granulosus ETS transcription factor Elf 5 0.0024 0.0068 0.007
Echinococcus granulosus mothers against decapentaplegic 5 0.0019 0.0008 0.0008
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0152 0.1484 0.153
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0042 0.0267 0.1209
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0031 0.0144 0.0482
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0031 0.0144 0.061
Loa Loa (eye worm) hypothetical protein 0.0151 0.1477 0.1996
Schistosoma mansoni ets-related 0.0024 0.0068 0.007
Plasmodium falciparum JmjC domain-containing protein, putative 0.0026 0.0094 0.0396
Echinococcus multilocularis ETS transcription factor Elf 2 0.0024 0.0068 0.0068
Echinococcus granulosus geminin 0.0347 0.3641 0.3754
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0052 0.038 0.1611
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0031 0.0144 0.1332
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0124 0.117 0.1581
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.004 0.0246 0.0253
Schistosoma mansoni heat shock protein 0.0135 0.1295 0.1336
Loa Loa (eye worm) nuclear hormone receptor 0.0087 0.0768 0.1038
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0174 0.1723 0.1777
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0036 0.0202 0.0559
Loa Loa (eye worm) hypothetical protein 0.0026 0.0094 0.0127
Giardia lamblia DNA topoisomerase II 0.015 0.1468 0.6669
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0031 0.0144 0.0482
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0038 0.0126
Giardia lamblia Kinase, CMGC MAPK 0.0059 0.045 0.2043
Echinococcus multilocularis flap endonuclease 1 0.0057 0.0437 0.0437
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0239 0.08
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0031 0.0144 0.0399
Loa Loa (eye worm) hypothetical protein 0.0087 0.0768 0.1038
Echinococcus granulosus nuclear receptor nhr 48 0.0087 0.0768 0.0792
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0077 0.0109
Trypanosoma brucei DNA polymerase kappa, putative 0.0237 0.242 0.6723
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0075 0.0632 0.2869
Schistosoma mansoni blooms syndrome DNA helicase 0.0027 0.0096 0.0099
Loa Loa (eye worm) RNA binding protein 0.0072 0.0598 0.0809
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0095 0.0857 0.0884
Echinococcus granulosus ecdysone induced protein 78C 0.0185 0.185 0.1908
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0185 0.185 0.1908
Schistosoma mansoni jun-related protein 0.0219 0.2226 0.2295
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0152 0.148 0.4055
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0055 0.0405 0.1839
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0226 0.0627
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.045 0.0464
Brugia malayi jmjC domain containing protein 0.0026 0.0094 0.0133
Plasmodium falciparum endoplasmin, putative 0.0092 0.0819 0.3479
Brugia malayi MH1 domain containing protein 0.0019 0.0008 0.0011
Echinococcus multilocularis JmjC domain containing protein 4 0.0026 0.0094 0.0094
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0069 0.0565 0.0763
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0026 0.0085 0.0359
Echinococcus multilocularis heat shock protein 90 0.0104 0.0953 0.0953
Trypanosoma brucei heat shock protein, putative 0.0135 0.1295 0.3597
Brugia malayi jmjC domain containing protein 0.0103 0.0937 0.1326
Schistosoma mansoni nuclear hormone receptor 0.0087 0.0768 0.0792
Echinococcus granulosus expressed protein 0.0069 0.0565 0.0582
Brugia malayi Hsp90 protein 0.0065 0.0525 0.0743
Brugia malayi Pre-SET motif family protein 0.0029 0.0118 0.0167
Trypanosoma brucei DNA polymerase kappa, putative 0.0152 0.148 0.411
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0031 0.0144 0.1434
Brugia malayi Nuclear hormone receptor-like 1 0.0185 0.185 0.2619
Onchocerca volvulus 0.0025 0.0077 0.013
Schistosoma mansoni flap endonuclease-1 0.0052 0.0376 0.0387
Brugia malayi Ets-domain containing protein 0.0166 0.1637 0.2316
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0598 0.0617
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0185 0.185 0.1908
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0031 0.0144 0.0482
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0031 0.0144 0.0399
Brugia malayi Ets-domain containing protein 0.0024 0.0068 0.0096
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0598 0.0617
Loa Loa (eye worm) hypothetical protein 0.0024 0.0068 0.0092
Trypanosoma cruzi DNA polymerase kappa, putative 0.0237 0.242 0.6723
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0077 0.0257
Trypanosoma cruzi DNA repair protein, putative 0.0023 0.0053 0.0144
Trypanosoma cruzi DNA polymerase kappa, putative 0.0237 0.242 0.6723
Schistosoma mansoni cpg binding protein 0.0063 0.0497 0.0512
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0267 0.0739
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.045 0.151
Trypanosoma brucei DNA polymerase kappa, putative 0.0151 0.1477 0.4102
Echinococcus granulosus poly (ADP ribose) polymerase 0.0054 0.0399 0.0411
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0026 0.0085 0.0236
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0077 0.0257
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0042 0.0267 0.0275
Giardia lamblia Grp94/Hsp90 0.0108 0.1001 0.4549
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.001
Leishmania major heat shock protein 83-1 0.0135 0.1295 0.3538
Echinococcus granulosus poly (ADP ribose) polymerase 0.0027 0.01 0.0103
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0065 0.0525 0.0525
Plasmodium vivax flap endonuclease 1, putative 0.0057 0.0437 0.1853
Plasmodium falciparum DNA gyrase subunit B 0.0115 0.1078 0.4579
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0031 0.0144 0.0144
Brugia malayi conserved hypotetical protein 0.0087 0.0768 0.1087
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0087 0.0768 0.0768
Echinococcus granulosus sterol regulatory element binding protein 0.0048 0.0333 0.0343
Mycobacterium tuberculosis Probable two component sensor kinase 0.0031 0.0144 0.0761
Brugia malayi small heat shock protein 0.0656 0.7066 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0185 0.185 0.1908
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0026 0.0094 0.0259
Schistosoma mansoni cpg binding protein 0.0066 0.0536 0.0553
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0185 0.185 0.185
Schistosoma mansoni Smad4 0.0019 0.0008 0.0008
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0118 0.0498
Loa Loa (eye worm) hypothetical protein 0.0092 0.0826 0.1116
Entamoeba histolytica Flap nuclease, putative 0.0057 0.0437 0.1981
Echinococcus granulosus peregrin 0.0027 0.0095 0.0098
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0038 0.0013
Schistosoma mansoni Lamin B receptor (ERG24) 0.0071 0.0582 0.06
Schistosoma mansoni transcription factor btf3 0.004 0.0241 0.0249
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0185 0.185 0.3136
Plasmodium vivax JmjC domain containing protein 0.0026 0.0094 0.0396
Mycobacterium ulcerans hypothetical protein 0.0025 0.0077 0.0257
Leishmania major heat shock protein 83-1 0.0135 0.1295 0.3538
Echinococcus multilocularis PHD finger protein rhinoceros 0.0027 0.0095 0.0095
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0217 0.2201 0.2269
Echinococcus granulosus heat shock protein 90 0.0135 0.1295 0.1336
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0267 0.0739
Mycobacterium tuberculosis Conserved hypothetical protein 0.0181 0.1802 1
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0239 0.08
Onchocerca volvulus 0.0055 0.0408 0.0691
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0036 0.0202 0.0202
Giardia lamblia Sgs1 DNA helicase, putative 0.0052 0.038 0.1722
Onchocerca volvulus 0.0185 0.185 0.3136
Loa Loa (eye worm) hypothetical protein 0.0185 0.185 0.2501
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0565 0.1894
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0598 0.0617
Trichomonas vaginalis CAMK family protein kinase 0.0217 0.2201 0.7388
Schistosoma mansoni hypothetical protein 0.0024 0.0068 0.007
Schistosoma mansoni ap endonuclease 0.0021 0.0038 0.0039
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0036 0.0202 0.0202
Echinococcus multilocularis isocitrate dehydrogenase 0.0036 0.0202 0.0202
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0185 0.185 0.2619
Onchocerca volvulus 0.0025 0.0073 0.0123
Echinococcus multilocularis poly (adp ribose) polymerase 2 0.0095 0.0857 0.0857
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0075 0.0632 0.0894
Plasmodium vivax SET domain protein, putative 0.0029 0.0118 0.0498
Schistosoma mansoni serine/threonine protein kinase 0.0217 0.2201 0.2269
Schistosoma mansoni survival motor neuron protein 0.0055 0.0408 0.0421
Loa Loa (eye worm) hypothetical protein 0.0022 0.0043 0.0058
Brugia malayi beta-NAC-like protein 0.004 0.0241 0.0342
Loa Loa (eye worm) hypothetical protein 0.0081 0.0694 0.0938
Mycobacterium ulcerans putative regultory protein 0.0031 0.0144 0.0482
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0038 0.0348
Loa Loa (eye worm) MH2 domain-containing protein 0.0019 0.0008 0.001
Onchocerca volvulus 0.0093 0.0827 0.1401
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0052 0.038 0.0537
Brugia malayi hypothetical protein 0.0042 0.0262 0.0371
Echinococcus multilocularis Smad4 0.0019 0.0008 0.0008
Entamoeba histolytica hypothetical protein 0.004 0.0241 0.1094
Leishmania major DNA polymerase kappa, putative 0.0152 0.148 0.4055
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0241 0.0808
Trypanosoma brucei heat shock protein 84, putative 0.0065 0.0525 0.1457
Echinococcus granulosus FTZ F1 alpha 0.0185 0.185 0.1908
Brugia malayi nuclear hormone receptor 0.0087 0.0768 0.1087
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0026 0.0091 0.0094
Leishmania major DNA polymerase eta, putative 0.0068 0.0551 0.1452
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0185 0.185 0.2501

Activities

Activity type Activity value Assay description Source Reference
Kd (binding) = 20 nM BindingDB_Patents: Biochemical Assay. Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacement assay. The identification of compounds capable of binding several PARP proteins is carried out through a screening method including the steps of a) providing a reaction mixture containing: the PARP protein isoform under investigation, a compound of formula (IP): wherein R11 is hydrogen atom or a methyl group, B is (CH2)n NH group wherein n is 2 to 6; m is 0 or 1 and X- is a counterion, andserial dilutions of the test compound; b) comparing the polarization signal generated in the absence of the test compound with the one generated in the presence of different concentrations of the test compound, andc) evaluating the ability of the test compound to displace the compound of formula (IP) as defined above indicated from a decreased fluorescence polarization level. ChEMBL. No reference
Kd (binding) = 20 nM Biochemical Assay BINDINGDB. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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