Detailed information for compound 203574

Basic information

Technical information
  • TDR Targets ID: 203574
  • Name: 3-[(3-bromo-5-methoxy-4-octoxyphenyl)methylam ino]propylphosphonic acid
  • MW: 466.347 | Formula: C19H33BrNO5P
  • H donors: 3 H acceptors: 3 LogP: 1.59 Rotable bonds: 15
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCCOc1c(Br)cc(cc1OC)CNCCCP(=O)(O)O
  • InChi: 1S/C19H33BrNO5P/c1-3-4-5-6-7-8-11-26-19-17(20)13-16(14-18(19)25-2)15-21-10-9-12-27(22,23)24/h13-14,21H,3-12,15H2,1-2H3,(H2,22,23,24)
  • InChiKey: WECRLAZSZWCWDE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[(3-bromo-5-methoxy-4-octoxy-phenyl)methylamino]propylphosphonic acid
  • 3-[(3-bromo-5-methoxy-4-octoxy-benzyl)amino]propylphosphonic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens sphingosine-1-phosphate receptor 3 Starlite/ChEMBL References
Homo sapiens sphingosine-1-phosphate receptor 2 Starlite/ChEMBL References
Homo sapiens sphingosine-1-phosphate receptor 1 Starlite/ChEMBL References
Homo sapiens sphingosine-1-phosphate receptor 5 Starlite/ChEMBL References
Homo sapiens sphingosine-1-phosphate receptor 4 Starlite/ChEMBL References
Homo sapiens lysophosphatidic acid receptor 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0025 0.0031 0.0072
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0021 0.002 0.0016
Loa Loa (eye worm) TYRA-2 protein 0.0021 0.002 0.0047
Trichomonas vaginalis rotamase, putative 0.0036 0.0068 0.0118
Schistosoma mansoni neuropeptide F-like receptor 0.0021 0.002 0.0022
Brugia malayi TAR-binding protein 0.0063 0.0157 0.0365
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0152 0.0452 0.1072
Brugia malayi Nuclear hormone receptor-like 1 0.0047 0.0104 0.024
Echinococcus multilocularis lamin dm0 0.0144 0.0427 0.0422
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0011 0.0118
Onchocerca volvulus Protein ultraspiracle homolog 0.0047 0.0104 0.0179
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.0409 0.3385
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0019 0.0015
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0047
Onchocerca volvulus 0.0021 0.002 0.0004
Entamoeba histolytica hypothetical protein 0.0069 0.0178 0.0453
Schistosoma mansoni glutamate receptor AMPA 0.0025 0.0031 0.0033
Echinococcus granulosus peptide allatostatin:somatostatin 0.0021 0.002 0.0016
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.01 0.028 0.0298
Echinococcus multilocularis transcription factor btf3 0.0069 0.0178 0.0173
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0073 0.0068
Echinococcus multilocularis glutamate receptor 4 0.0042 0.0087 0.0083
Trichomonas vaginalis phosphofructokinase, putative 0.023 0.0711 0.1461
Echinococcus multilocularis g protein coupled receptor 0.0021 0.002 0.0016
Loa Loa (eye worm) hypothetical protein 0.0056 0.0136 0.0322
Leishmania major ATP-dependent phosphofructokinase 0.023 0.0711 0.5893
Trichomonas vaginalis pps1 dual specificty phosphatase, putative 0.0564 0.1816 0.3769
Echinococcus granulosus thyroid hormone receptor alpha 0.0022 0.0022 0.0018
Echinococcus granulosus alpha 1A adrenergic receptor 0.0021 0.002 0.0016
Echinococcus multilocularis voltage dependent calcium channel subunit 0.138 0.452 0.4518
Echinococcus granulosus g protein coupled receptor 0.0021 0.002 0.0016
Echinococcus granulosus Excitatory amino acid transporter 0.0249 0.0774 0.077
Echinococcus multilocularis excitatory amino acid transporter 2 0.0249 0.0774 0.077
Echinococcus granulosus dro:myosuppressin receptor 0.0021 0.002 0.0016
Brugia malayi photoreceptor-specific nuclear receptor 0.0047 0.0104 0.024
Loa Loa (eye worm) nuclear receptor NHR-67 0.0022 0.0022 0.0051
Brugia malayi Regulator of G protein signaling domain containing protein 0.0041 0.0086 0.0198
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1196 0.3909 0.8143
Leishmania major basic transcription factor 3a, putative 0.0069 0.0178 0.1454
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0022 0.0021 0.0017
Brugia malayi putative neuropeptide receptor NPR1 0.0021 0.002 0.0041
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0047
Loa Loa (eye worm) hypothetical protein 0.0025 0.0031 0.0072
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0084 0.0227 0.1152
Mycobacterium tuberculosis Probable aldehyde dehydrogenase AldC 0.0021 0.0018 0.0037
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0025 0.0031 0.0072
Entamoeba histolytica hypothetical protein, conserved 0.0056 0.0136 0.0346
Schistosoma mansoni pyruvate kinase 0.0017 0.0004 0.0005
Echinococcus multilocularis pyruvate kinase 0.0032 0.0057 0.0052
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0056 0.0136 0.026
Schistosoma mansoni myosin xvIII 0.0021 0.002 0.0022
Echinococcus multilocularis L aminoadipate semialdehyde 0.0168 0.0504 0.05
Toxoplasma gondii histone lysine methyltransferase SET1 0.0121 0.0351 0.2914
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.0249 0.0774 1
Onchocerca volvulus 0.0021 0.002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0042 0.0087 0.0207
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0021 0.002 0.0022
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0042 0.0089 0.0205
Onchocerca volvulus 0.0021 0.0019 0.0002
Echinococcus granulosus tissue type plasminogen activator 0.0022 0.0022 0.0018
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0379 0.1204 0.12
Trypanosoma brucei delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0021 0.0018 0.0166
Schistosoma mansoni pyruvate kinase 0.0032 0.0057 0.006
Brugia malayi MAP kinase sur-1 0.0104 0.0292 0.0687
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0025 0.0021
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0021 0.002 0.0022
Echinococcus granulosus voltage dependent calcium channel subunit 0.138 0.452 0.4518
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0011 0.0091
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0157 0.0371
Schistosoma mansoni ap endonuclease 0.0038 0.0076 0.0081
Onchocerca volvulus 0.0021 0.002 0.0004
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0104 0.0292 0.3166
Brugia malayi Bromodomain containing protein 0.0022 0.0021 0.0044
Loa Loa (eye worm) nuclear hormone receptor 0.0022 0.0022 0.0051
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0021 0.0018 0.0193
Brugia malayi hypothetical protein 0.0021 0.002 0.0041
Echinococcus multilocularis neuropeptide receptor 0.0021 0.002 0.0016
Trypanosoma brucei pyruvate kinase 1, putative 0.0032 0.0057 0.0584
Schistosoma mansoni lipoxygenase 0.0021 0.0019 0.0021
Entamoeba histolytica elongation factor-2 kinase, putative 0.0056 0.0136 0.0346
Onchocerca volvulus Alhambra homolog 0.0022 0.0021 0.0006
Echinococcus granulosus betaine aldehyde dehydrogenase 0.0021 0.0018 0.0014
Brugia malayi conserved hypotetical protein 0.0022 0.0022 0.0046
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0022 0.0022 0.0018
Brugia malayi Regulator of G protein signaling domain containing protein 0.0041 0.0086 0.0198
Onchocerca volvulus 0.006 0.015 0.0275
Brugia malayi von Willebrand factor type A domain containing protein 0.0056 0.0136 0.0316
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0047
Toxoplasma gondii pyruvate kinase PyK1 0.0032 0.0057 0.0467
Trypanosoma cruzi transcription factor btf3, putative 0.0069 0.0178 0.1922
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0047 0.0104 0.01
Loa Loa (eye worm) hypothetical protein 0.0022 0.0022 0.0051
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0043 0.0091 0.0087
Leishmania major trypanothione reductase 0.0037 0.0071 0.0567
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.011 0.0315 0.0336
Schistosoma mansoni regulator of G protein signaling 0.0041 0.0086 0.0092
Brugia malayi neuropeptide F receptor 0.0021 0.002 0.0041
Brugia malayi nuclear receptor NHR-67 0.0022 0.0022 0.0046
Schistosoma mansoni serine/threonine protein kinase 0.0104 0.0292 0.0311
Loa Loa (eye worm) hypothetical protein 0.0056 0.0136 0.0322
Brugia malayi GnHR receptor homolog 0.0021 0.002 0.0041
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0035 0.0065 0.0518
Echinococcus granulosus collagen alpha 1VII chain 0.0056 0.0136 0.0132
Mycobacterium ulcerans piperideine-6-carboxilic acid dehydrogenase Pcd 0.0021 0.0018 0.0081
Leishmania major delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0021 0.0018 0.0127
Echinococcus multilocularis FTZ F1 alpha 0.0047 0.0104 0.01
Leishmania major hypothetical protein, conserved 0.0022 0.0022 0.0159
Loa Loa (eye worm) hypothetical protein 0.0025 0.0031 0.0072
Echinococcus multilocularis serotonin receptor 0.0021 0.002 0.0016
Brugia malayi 6-phosphofructokinase 0.023 0.0711 0.1682
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0025 0.0031 0.0033
Loa Loa (eye worm) phosphofructokinase 0.023 0.0711 0.1687
Schistosoma mansoni hypothetical protein 0.0021 0.002 0.0022
Echinococcus granulosus FTZ F1 alpha 0.0047 0.0104 0.01
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0104 0.0292 0.3166
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0047 0.0104 0.01
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0062 0.0155 0.0386
Toxoplasma gondii aldehyde dehydrogenase 0.0379 0.1204 1
Brugia malayi Cache domain containing protein 0.0611 0.1973 0.4682
Brugia malayi nuclear receptor NHR-88 0.0022 0.0022 0.0046
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0076 0.0072
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0071 0.0319
Loa Loa (eye worm) glutamate receptor 1 0.0067 0.017 0.0402
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0073 0.0068
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0119 0.0127
Brugia malayi von Willebrand Factor 0.0056 0.0136 0.0316
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.0409 0.444
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0104 0.0292 0.2424
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0021 0.002 0.0016
Echinococcus multilocularis g protein coupled receptor 0.0021 0.002 0.0016
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.007 0.018 0.0175
Loa Loa (eye worm) hypothetical protein 0.0051 0.0119 0.0281
Loa Loa (eye worm) hypothetical protein 0.026 0.0809 0.1921
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.0056 0.0136 0.2349
Mycobacterium ulcerans aldehyde dehydrogenase 0.0379 0.1204 0.6384
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0011 0.0091
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0231 0.0714 0.1694
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0021 0.0018 0.0045
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0089 0.0095
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.002 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0178 0.0347
Plasmodium vivax thrombospondin-related anonymous protein 0.0056 0.0136 0.2349
Schistosoma mansoni lipoxygenase 0.0059 0.0145 0.0155
Brugia malayi phosphofructokinase 0.023 0.0711 0.1682
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1196 0.3909 0.8143
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0019 0.0045
Schistosoma mansoni metabotropic glutamate receptor 0.0079 0.0211 0.0225
Echinococcus granulosus pyruvate kinase 0.0032 0.0057 0.0052
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1196 0.3909 1
Schistosoma mansoni aldehyde dehydrogenase 0.0379 0.1204 0.1283
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0021 0.002 0.0016
Brugia malayi beta-NAC-like protein 0.0069 0.0178 0.0415
Echinococcus multilocularis regulator of G protein signaling 3 0.0041 0.0086 0.0082
Schistosoma mansoni transcription factor btf3 0.0069 0.0178 0.0189
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0021 0.0018 0.0166
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0047 0.0104 0.0246
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0152 0.0452 0.1067
Loa Loa (eye worm) hypothetical protein 0.0041 0.0086 0.0203
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0076 0.4151
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0043 0.0091 0.0737
Trichomonas vaginalis pyruvate kinase, putative 0.0032 0.0057 0.0095
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0025 0.0031 0.0027
Loa Loa (eye worm) G-protein coupled receptor 0.0021 0.002 0.0047
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0036 0.0068 0.016
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0043 0.0091 0.0087
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0047 0.0104 0.0246
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0047 0.0105 0.0544
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0024 0.0061
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0011 0.0118
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0021 0.002 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0086 0.0156
Echinococcus granulosus mitogen activated protein kinase 3 0.0104 0.0292 0.0288
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0022 0.0022 0.0317
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0047 0.0104 0.01
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0047
Trichomonas vaginalis phosphofructokinase, putative 0.0062 0.0155 0.03
Echinococcus multilocularis orexin receptor type 2 0.0021 0.002 0.0016
Brugia malayi hypothetical protein 0.0106 0.0301 0.0707
Entamoeba histolytica hypothetical protein, conserved 0.0056 0.0136 0.0346
Echinococcus granulosus lamin dm0 0.0144 0.0427 0.0422
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0047
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0047 0.0104 0.024
Schistosoma mansoni hypothetical protein 0.0056 0.0136 0.0145
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.003 0.005 0.041
Loa Loa (eye worm) hypothetical protein 0.0027 0.004 0.0094
Schistosoma mansoni hypothetical protein 0.0713 0.231 0.2462
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.008 0.0215 0.0505
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0021 0.002 0.0022
Schistosoma mansoni metabotropic glutamate receptor 0.0048 0.0108 0.0115
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0019 0.0015
Trichomonas vaginalis rotamase, putative 0.0035 0.0065 0.0112
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.003 0.005 0.0045
Onchocerca volvulus 0.0021 0.002 0.0004
Echinococcus multilocularis tissue type plasminogen activator 0.0022 0.0022 0.0018
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0038 0.0075 0.007
Schistosoma mansoni hypothetical protein 0.0048 0.0108 0.0115
Entamoeba histolytica hypothetical protein 0.0041 0.0086 0.0219
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.003 0.005 0.0045
Brugia malayi metabotropic glutamate receptor type 2 0.0048 0.0108 0.025
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0062 0.0155 0.03
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0047
Brugia malayi Pre-SET motif family protein 0.0186 0.0564 0.1334
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0021 0.002 0.0022
Mycobacterium ulcerans aldehyde dehydrogenase 0.0021 0.0018 0.0081
Mycobacterium ulcerans bifunctional acetaldehyde-CoA/alcohol dehydrogenase 0.0021 0.0018 0.0081
Schistosoma mansoni retinoic acid receptor RXR 0.0047 0.0104 0.0111
Schistosoma mansoni growth hormone secretagogue receptor 0.0021 0.002 0.0022
Loa Loa (eye worm) delta-1-pyrroline-5-carboxylate dehydrogenase 0.0021 0.0018 0.0042
Echinococcus granulosus mixed lineage leukemia protein mll 0.0022 0.0021 0.0017
Schistosoma mansoni hypothetical protein 0.0104 0.0293 0.0312
Schistosoma mansoni neuropeptide receptor 0.0021 0.002 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0086 0.0156
Echinococcus granulosus 7tm_1 domain containing protein 0.0021 0.002 0.0016
Leishmania major aldehyde dehydrogenase, putative 0.0021 0.0018 0.0127
Echinococcus multilocularis fmrfamide receptor 0.0021 0.002 0.0016
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase 0.0021 0.0018 0.0081
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0025 0.0033 0.0266
Loa Loa (eye worm) hypothetical protein 0.0022 0.0022 0.0051
Brugia malayi regulator of G-protein signaling egl-10 0.0041 0.0086 0.0198
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0157 0.0167
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.002 0.0016
Echinococcus granulosus g protein coupled receptor 0.0021 0.002 0.0016
Brugia malayi Glutamate receptor 2 precursor 0.0067 0.017 0.0396
Brugia malayi hypothetical protein 0.0056 0.0136 0.0316
Loa Loa (eye worm) hypothetical protein 0.0047 0.0104 0.0246
Loa Loa (eye worm) hypothetical protein 0.0056 0.0136 0.0322
Loa Loa (eye worm) hypothetical protein 0.0143 0.0424 0.1005
Echinococcus granulosus Solute carrier family 22 5 0.1109 0.3622 0.3619
Brugia malayi 6-phosphofructokinase 0.023 0.0711 0.1682
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0047 0.0104 0.024
Giardia lamblia PHD finger protein 15 0.0022 0.0021 0.0043
Plasmodium falciparum phd finger protein, putative 0.0022 0.0021 0.0978
Onchocerca volvulus 0.0047 0.0104 0.0179
Giardia lamblia Sgs1 DNA helicase, putative 0.003 0.005 0.0116
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0036 0.0068 0.0154
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0047
Mycobacterium tuberculosis Probable methylmalonate-semialdehyde dehydrogenase MmsA (methylmalonic acid semialdehyde dehydrogenase) (MMSDH) 0.0021 0.0018 0.0037
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0011 0.0118
Loa Loa (eye worm) hypothetical protein 0.0032 0.0057 0.0133
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0047 0.0104 0.0246
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0178 0.0537 0.0533
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0108 0.0104
Treponema pallidum 76K protein 0.0056 0.0136 0.0199
Mycobacterium tuberculosis Probable dehydrogenase 0.0084 0.0227 0.1152
Loa Loa (eye worm) hypothetical protein 0.0022 0.0022 0.0051
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0021 0.002 0.0047
Treponema pallidum methyl-accepting chemotaxis protein (mcp2-1) 0.2074 0.6818 1
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0047 0.0105 0.0871
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0047 0.0104 0.01
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.002 0.0022
Schistosoma mansoni lamin 0.0144 0.0427 0.0455
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0047 0.0105 0.0544
Toxoplasma gondii thioredoxin reductase 0.0037 0.0071 0.0586
Toxoplasma gondii microneme protein MIC2 0.0056 0.0136 0.1125
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0047 0.0104 0.01
Onchocerca volvulus 0.0144 0.0427 0.0854
Loa Loa (eye worm) jmjC domain-containing protein 0.0045 0.0098 0.0232
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0086 0.0903
Brugia malayi ecdysteroid receptor 0.0047 0.0104 0.024
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.002 0.0022
Schistosoma mansoni hypothetical protein 0.0021 0.0019 0.0021
Schistosoma mansoni delta 1-pyrroline-5-carboxylate synthetase 0.0021 0.0018 0.0019
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.003 0.005 0.0111
Echinococcus granulosus tachykinin peptides receptor 99D 0.0021 0.002 0.0016
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0047
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0047
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0115 0.033 0.0782
Plasmodium vivax hypothetical protein, conserved 0.0056 0.0136 0.2349
Echinococcus granulosus cpg binding protein 0.0064 0.0161 0.0157
Entamoeba histolytica phosphofructokinase, putative 0.023 0.0711 0.1817
Leishmania major aldehyde dehydrogenase, putative 0.0021 0.0018 0.0127
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0084 0.0227 0.1152
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0108 0.0104
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0021 0.0018 0.0014
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0073 0.0068
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0059 0.0145 0.0141
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0071 0.0185 0.0181
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.0249 0.0774 0.4074
Echinococcus multilocularis lysine specific demethylase 5A 0.0026 0.0036 0.0032
Brugia malayi von Willebrand factor type A domain containing protein 0.0056 0.0136 0.0316
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.002 0.0016
Echinococcus multilocularis survival motor neuron protein 1 0.026 0.0809 0.0805
Echinococcus multilocularis nuclear receptor nhr 48 0.0022 0.0022 0.0018
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1196 0.3909 0.8143
Toxoplasma gondii kringle domain-containing protein 0.0022 0.0022 0.018
Echinococcus granulosus ubiquitin specific protease 41 0.0043 0.0091 0.0087
Schistosoma mansoni amine GPCR 0.0021 0.002 0.0022
Echinococcus multilocularis 6 phosphofructokinase 0.023 0.0711 0.0707
Echinococcus multilocularis axis inhibition protein axin 0.0041 0.0086 0.0082
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0157 0.0167
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.002 0.0022
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0035 0.0065 0.0677
Echinococcus granulosus pyruvate kinase 0.0032 0.0057 0.0052
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0021 0.0018 0.0166
Echinococcus granulosus neutral amino acid transporter A 0.0249 0.0774 0.077
Brugia malayi Muscleblind-like protein 0.0143 0.0424 0.0999
Schistosoma mansoni loxhd1 0.0021 0.0019 0.0021
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.023 0.0711 0.3734
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.008 0.0213 0.0208
Echinococcus multilocularis regulator of G protein signaling 7 0.0041 0.0086 0.0082
Schistosoma mansoni neuropeptide f receptor 76f 0.0021 0.002 0.0022
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0121 0.0349 0.0822
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0032 0.0057 0.0242
Echinococcus multilocularis neuropeptide Y receptor 0.0021 0.002 0.0016
Schistosoma mansoni neuropeptide F-like receptor 0.0021 0.002 0.0022
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0003 0.0006
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0021 0.002 0.0022
Loa Loa (eye worm) hypothetical protein 0.0104 0.0293 0.0695
Mycobacterium tuberculosis Probable oxidoreductase 0.0093 0.0258 0.1318
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0021 0.0018 0.0045
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0121 0.0349 0.0345
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0108 0.0256
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1196 0.3909 0.8143
Entamoeba histolytica aldehyde dehydrogenase 1, putative 0.0021 0.0018 0.0045
Entamoeba histolytica hypothetical protein 0.0037 0.0073 0.0184
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0086 0.0156
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.0091 0.0167
Brugia malayi Protein kinase domain containing protein 0.0022 0.0022 0.0045
Schistosoma mansoni RAR-like nuclear receptor 0.0047 0.0104 0.0111
Echinococcus granulosus neuropeptide s receptor 0.0021 0.002 0.0016
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0047 0.0104 0.01
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0021 0.0018 0.0037
Loa Loa (eye worm) hypothetical protein 0.0022 0.0022 0.0051
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0029 0.0045 0.0048
Schistosoma mansoni survival motor neuron protein 0.0053 0.0125 0.0133
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0057 0.0133
Echinococcus granulosus RUN 0.0021 0.0019 0.0015
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0021 0.002 0.0041
Plasmodium falciparum cysteine repeat modular protein 1 0.0022 0.0022 0.1025
Schistosoma mansoni z-protein (S1r protein) 0.0041 0.0086 0.0092
Brugia malayi Serotonin receptor 0.0021 0.002 0.0041
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0121 0.0349 0.0372
Echinococcus multilocularis RUN 0.0021 0.0019 0.0015
Brugia malayi hypothetical protein 0.0131 0.0382 0.0901
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0011 0.0028
Leishmania major hypothetical protein, conserved 0.0051 0.0119 0.0967
Schistosoma mansoni hypothetical protein 0.0056 0.0136 0.0145
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1196 0.3909 0.8143
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0019 0.0015
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0076 0.039
Brugia malayi Nuclear hormone receptor-like 1 0.0025 0.0031 0.0066
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0021 0.002 0.0016
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0076 0.0136
Loa Loa (eye worm) hypothetical protein 0.0056 0.0136 0.0322
Schistosoma mansoni rotamase 0.0036 0.0068 0.0072
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0047 0.0104 0.0246
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0231 0.0714 0.0709
Schistosoma mansoni amine GPCR 0.0021 0.002 0.0022
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0113 0.0322 0.0764
Echinococcus granulosus regulator of G protein signaling 3 0.0041 0.0086 0.0082
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0076 0.0184
Plasmodium vivax pyruvate kinase, putative 0.0032 0.0057 0.0934
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0115 0.033 0.0777
Loa Loa (eye worm) CUTiclin family member 0.0056 0.0136 0.0322
Plasmodium vivax SET domain protein, putative 0.0186 0.0564 1
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0043 0.0091 0.0087
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0021 0.0018 0.0193
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.002 0.0016
Leishmania major pyrroline-5-carboxylate synthetase-like protein 0.0021 0.0018 0.0127
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0047
Echinococcus granulosus glutamate receptor 1 0.0042 0.0087 0.0083
Echinococcus granulosus axis inhibition protein axin 0.0041 0.0086 0.0082
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0104 0.0292 0.2408
Loa Loa (eye worm) DR-78 0.0022 0.0022 0.0051
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0041 0.0086 0.0082
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0077 0.0205 0.0486
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0043 0.0091 0.0223
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0076 0.0194
Brugia malayi nuclear hormone receptor family member nhr-6 0.0022 0.0022 0.0046
Schistosoma mansoni aldehyde dehydrogenase 0.0021 0.0018 0.0019
Brugia malayi G protein-coupled receptor F59B2.13 0.0021 0.002 0.0041
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.002 0.0016
Loa Loa (eye worm) hypothetical protein 0.0067 0.0171 0.0405
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0021 0.002 0.0047
Schistosoma mansoni adenoreceptor 0.0021 0.002 0.0022
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.0056 0.0136 0.7593
Loa Loa (eye worm) hypothetical protein 0.0047 0.0104 0.0246
Loa Loa (eye worm) aldehyde dehydrogenase 0.0021 0.0018 0.0042
Echinococcus granulosus axis inhibition protein axin 0.0041 0.0086 0.0082
Loa Loa (eye worm) hypothetical protein 0.0022 0.0022 0.0051
Plasmodium vivax basic transcription factor 3b, putative 0.0069 0.0178 0.3094
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0022 0.0022 0.0051
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0025 0.0034 0.0029
Schistosoma mansoni hypothetical protein 0.0022 0.0021 0.0023
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0021 0.002 0.0016
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0115 0.033 0.0326
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0076 0.0767
Brugia malayi larval opioid receptor 0.0021 0.002 0.0041
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0584 0.1884 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0071 0.0185 0.0181
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.002 0.0016
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0021 0.002 0.0016
Plasmodium falciparum basic transcription factor 3b, putative 0.0069 0.0178 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.003 0.0048 0.0051
Loa Loa (eye worm) RGS-3 protein 0.0041 0.0086 0.0203
Echinococcus multilocularis neutral amino acid transporter A 0.0249 0.0774 0.077
Schistosoma mansoni hypothetical protein 0.0021 0.0018 0.0019
Echinococcus granulosus glutamate receptor 4 0.0042 0.0087 0.0083
Echinococcus multilocularis ubiquitin specific protease 41 0.0043 0.0091 0.0087
Loa Loa (eye worm) steroid hormone receptor 0.0047 0.0104 0.0246
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0047 0.0104 0.0111
Echinococcus multilocularis neutral amino acid transporter A 0.0249 0.0774 0.077
Loa Loa (eye worm) hypothetical protein 0.0022 0.0022 0.0051
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0022 0.0018
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0035 0.0065 0.0165
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0047
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.011 0.0315 0.0336
Echinococcus multilocularis excitatory amino acid transporter 3 0.0249 0.0774 0.077
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0047
Onchocerca volvulus 0.0021 0.002 0.0004
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.002 0.0016
Trichomonas vaginalis phosphofructokinase, putative 0.0062 0.0155 0.03
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0047 0.0104 0.024
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0047 0.0105 0.0154
Mycobacterium ulcerans hypothetical protein 0.0155 0.0461 0.2438
Echinococcus granulosus tm gpcr rhodopsin 0.0021 0.002 0.0016
Echinococcus granulosus jumonji domain containing protein 0.003 0.005 0.0045
Onchocerca volvulus 0.0021 0.002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0047 0.0104 0.0246
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0047
Trichomonas vaginalis phosphofructokinase, putative 0.0062 0.0155 0.03
Schistosoma mansoni hypothetical protein 0.0023 0.0025 0.0027
Brugia malayi hypothetical protein 0.0021 0.002 0.0041
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0073 0.0077
Brugia malayi von Willebrand factor type A domain containing protein 0.0056 0.0136 0.0316
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0119 0.1288
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0249 0.0774 0.077
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0043 0.0091 0.0097
Loa Loa (eye worm) hypothetical protein 0.0041 0.0086 0.0203
Entamoeba histolytica transcription factor BTF3, putative 0.0069 0.0178 0.0453
Loa Loa (eye worm) hypothetical protein 0.0143 0.0424 0.1005
Schistosoma mansoni rab6-interacting 0.0021 0.0019 0.0021
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0265 0.0828 0.0824
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0021 0.002 0.0016
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0114 0.0327 0.0322
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0121 0.0349 0.1839
Loa Loa (eye worm) hypothetical protein 0.0022 0.0022 0.0051
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0073 0.0068
Entamoeba histolytica hypothetical protein 0.0037 0.0073 0.0184
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.002 0.0022
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0041 0.0086 0.0203
Echinococcus multilocularis g protein coupled receptor 0.0021 0.002 0.0016
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0065 0.0702
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0186 0.0564 0.0601
Schistosoma mansoni rab6-interacting 0.0021 0.0019 0.0021
Onchocerca volvulus Bile acid receptor homolog 0.0047 0.0104 0.0179
Schistosoma mansoni hypothetical protein 0.0048 0.0108 0.0115
Echinococcus multilocularis neuropeptide FF receptor 2 0.0021 0.002 0.0016
Entamoeba histolytica hypothetical protein 0.0037 0.0073 0.0184
Loa Loa (eye worm) glutathione reductase 0.0037 0.0071 0.0168
Echinococcus granulosus 6 phosphofructokinase 0.023 0.0711 0.0707
Echinococcus multilocularis tumor protein p63 0.035 0.1108 0.1104
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0071 0.0168
Echinococcus granulosus biogenic amine 5HT receptor 0.0021 0.002 0.0016
Echinococcus multilocularis regulator of G protein signaling 3 0.0041 0.0086 0.0082
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0186 0.0564 0.056
Loa Loa (eye worm) hypothetical protein 0.0022 0.0022 0.0051
Echinococcus multilocularis G-protein coupled receptor, putative 0.0021 0.002 0.0016
Onchocerca volvulus 0.0021 0.002 0.0004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.002 0.0022
Schistosoma mansoni pyruvate kinase 0.0032 0.0057 0.006
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0011 0.0091
Loa Loa (eye worm) hypothetical protein 0.003 0.005 0.0117
Brugia malayi Dopamine receptor 0.0021 0.002 0.0041
Echinococcus granulosus glutamate receptor 2 0.007 0.0182 0.0178
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0047
Schistosoma mansoni biogenic amine receptor 0.0021 0.002 0.0022
Echinococcus granulosus Nuclear hormone receptor HR96 0.0022 0.0022 0.0018
Echinococcus granulosus excitatory amino acid transporter 2 0.0249 0.0774 0.077
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0022 0.0018
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0076 0.1284
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0021 0.002 0.0022
Plasmodium falciparum pyruvate kinase 0.0032 0.0057 0.3018
Brugia malayi putative neuropeptide receptor 0.0021 0.002 0.0041
Echinococcus multilocularis glutamate receptor 2 0.008 0.0213 0.0208
Loa Loa (eye worm) aldehyde dehydrogenase 4 0.0021 0.0018 0.0042
Brugia malayi jmjC domain containing protein 0.0071 0.0185 0.0433
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0104 0.0292 0.3166
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0076 0.0136
Brugia malayi nuclear hormone receptor family member odr-7 0.0022 0.0022 0.0046
Echinococcus granulosus Regulator of G protein signaling 20 0.0041 0.0086 0.0082
Brugia malayi neuropeptide F receptor 0.0021 0.002 0.0041
Brugia malayi Calcitonin receptor-like protein seb-1 0.0152 0.0452 0.1067
Brugia malayi sulfakinin receptor protein 0.0021 0.002 0.0041
Brugia malayi nuclear hormone receptor 0.0047 0.0104 0.024
Schistosoma mansoni aldehyde dehydrogenase 0.0379 0.1204 0.1283
Schistosoma mansoni sodium/chloride dependent transporter 0.0016 0.0002 0.0003
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0021 0.0049
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0011 0.007
Mycobacterium ulcerans gamma-aminobutyraldehyde dehydrogenase 0.0021 0.0018 0.0081
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0057 0.0133
Echinococcus multilocularis neuropeptide receptor 0.0021 0.002 0.0016
Trypanosoma brucei transcription factor BTF3, putative 0.0069 0.0178 0.19
Loa Loa (eye worm) hypothetical protein 0.0025 0.0031 0.0072
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0021 0.0018 0.0193
Echinococcus multilocularis neuropeptide Y receptor 0.0021 0.002 0.0016
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0047 0.0104 0.024
Loa Loa (eye worm) TK/ROR protein kinase 0.0022 0.0022 0.0051
Brugia malayi Pyruvate kinase, muscle isozyme 0.0032 0.0057 0.0128
Schistosoma mansoni polycystin 1-related 0.0021 0.0019 0.0021
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0186 0.0564 0.0601
Brugia malayi CXXC zinc finger family protein 0.006 0.015 0.0348
Loa Loa (eye worm) hypothetical protein 0.0048 0.0108 0.0256
Onchocerca volvulus 0.0056 0.0136 0.0246
Loa Loa (eye worm) hypothetical protein 0.0047 0.0104 0.0246
Mycobacterium ulcerans aldehyde dehydrogenase (NAD+) dependent 0.0021 0.0018 0.0081
Schistosoma mansoni hypothetical protein 0.0048 0.0108 0.0115
Schistosoma mansoni cpg binding protein 0.0064 0.0161 0.0172
Toxoplasma gondii peptidylprolyl isomerase 0.0035 0.0065 0.0538
Echinococcus granulosus neuropeptide receptor 0.0021 0.002 0.0016
Schistosoma mansoni glutamate receptor kainate 0.0025 0.0031 0.0033
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0157 0.0167
Echinococcus granulosus fmrfamide receptor 0.0021 0.002 0.0016
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0084 0.0227 0.1119
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0059 0.0145 0.0141
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0086 0.0156
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0033 0.0059 0.0631
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0157 0.0167
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0043 0.0091 0.0087
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0025 0.0031 0.0027
Schistosoma mansoni aldehyde dehydrogenase 0.0021 0.0018 0.0019
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0025 0.0031 0.0027
Schistosoma mansoni hypothetical protein 0.0439 0.1403 0.1496
Schistosoma mansoni regulator of G protein signaling 0.0041 0.0086 0.0092
Brugia malayi hypothetical protein 0.0021 0.002 0.0041
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1196 0.3909 0.8143
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0047
Schistosoma mansoni amine GPCR 0.0021 0.002 0.0022
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0019 0.0864
Brugia malayi POT family protein 0.0087 0.0239 0.056
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0047
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0047
Schistosoma mansoni hypothetical protein 0.0022 0.0022 0.0024
Entamoeba histolytica hypothetical protein 0.0041 0.0086 0.0219
Chlamydia trachomatis neutral amino acid transporter 0.011 0.0315 0.3599
Onchocerca volvulus 0.0021 0.002 0.0004
Brugia malayi hypothetical protein 0.0021 0.002 0.0041
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.023 0.0711 0.7708
Treponema pallidum glutamate/aspartate transporter 0.011 0.0315 0.0461
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0041 0.0086 0.0156
Echinococcus granulosus peregrin 0.0022 0.0021 0.0017
Loa Loa (eye worm) hypothetical protein 0.01 0.028 0.0663
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.011 0.0315 0.0311
Brugia malayi hypothetical protein 0.0021 0.002 0.0041
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0021 0.002 0.0041
Echinococcus granulosus neuropeptide FF receptor 2 0.0021 0.002 0.0016
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0021 0.002 0.0041
Trypanosoma brucei pyruvate kinase 1 0.0032 0.0057 0.0584
Loa Loa (eye worm) intermediate filament protein 0.0144 0.0427 0.1012
Schistosoma mansoni jumonji/arid domain-containing protein 0.003 0.0048 0.0051
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0144 0.0427 0.1012
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0011 0.0091
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0047 0.0105 0.1803
Mycobacterium tuberculosis Probable pyrroline-5-carboxylate dehydrogenase RocA 0.0021 0.0018 0.0037
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0667 0.216 0.2301
Entamoeba histolytica phosphofructokinase, putative 0.023 0.0711 0.1817
Onchocerca volvulus 0.0056 0.0136 0.0246
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0062 0.0155 0.137
Schistosoma mansoni axis inhibition protein axin 0.0041 0.0086 0.0092
Brugia malayi PXA domain containing protein 0.0041 0.0086 0.0198
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0047
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0115 0.033 0.0352
Echinococcus granulosus orexin receptor type 2 0.0021 0.002 0.0016
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0057 0.008
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0062 0.0155 0.137
Loa Loa (eye worm) 6-phosphofructokinase 0.023 0.0711 0.1687
Schistosoma mansoni zinc finger protein 0.0022 0.0022 0.0024
Echinococcus granulosus serotonin receptor 0.0021 0.002 0.0016
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0022 0.0022 0.0018
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0021 0.0018 0.0193
Echinococcus multilocularis expressed protein 0.0036 0.0068 0.0064
Loa Loa (eye worm) glutamate receptor 2 0.0025 0.0031 0.0073
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0108 0.0104
Brugia malayi intermediate filament protein 0.0144 0.0427 0.1007
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase [NADP+] dependent, GabD1 0.0021 0.0018 0.0081
Loa Loa (eye worm) hypothetical protein 0.0041 0.0086 0.0203
Brugia malayi Zona pellucida-like domain containing protein 0.0056 0.0136 0.0316
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase [NADP+] dependent, PutA_2 0.0021 0.0018 0.0081
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.0056 0.0136 0.0322
Loa Loa (eye worm) hypothetical protein 0.0056 0.0136 0.0322
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0076 0.0797
Loa Loa (eye worm) hypothetical protein 0.0056 0.0136 0.0322
Echinococcus multilocularis Excitatory amino acid transporter 0.0249 0.0774 0.077
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0021 0.002 0.0016
Mycobacterium tuberculosis Probable aldehyde dehydrogenase NAD dependent AldA (aldehyde dehydrogenase [NAD+]) 0.0021 0.0018 0.0037
Trypanosoma cruzi pyruvate kinase 2, putative 0.0032 0.0057 0.061
Loa Loa (eye worm) ICD-1 protein 0.0069 0.0178 0.0421
Brugia malayi PHD-finger family protein 0.0022 0.0021 0.0044
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0101 0.0283 0.0302
Schistosoma mansoni cpg binding protein 0.0064 0.0161 0.0172
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0047 0.0104 0.0111
Leishmania major DNA polymerase eta, putative 0.0019 0.0011 0.007
Echinococcus granulosus Fatty aldehyde dehydrogenase 0.0021 0.0018 0.0014
Onchocerca volvulus 0.0056 0.0136 0.0246
Leishmania major pyruvate kinase 0.0032 0.0057 0.0447
Schistosoma mansoni blooms syndrome DNA helicase 0.0015 0 0.0001
Schistosoma mansoni hypothetical protein 0.0363 0.1153 0.1229
Mycobacterium ulcerans NAD-dependent aldehyde dehydrogenase AldA 0.0021 0.0018 0.0081
Echinococcus granulosus neuropeptide Y receptor 0.0021 0.002 0.0016
Loa Loa (eye worm) hypothetical protein 0.0042 0.0087 0.0207
Echinococcus granulosus neuropeptides capa receptor 0.0021 0.002 0.0016
Echinococcus multilocularis aldehyde dehydrogenase family 3 member B1 0.0021 0.0018 0.0014
Loa Loa (eye worm) hypothetical protein 0.0022 0.0022 0.0051
Schistosoma mansoni hypothetical protein 0.0363 0.1153 0.1229
Loa Loa (eye worm) hypothetical protein 0.0056 0.0136 0.0322
Schistosoma mansoni ap endonuclease 0.0038 0.0076 0.0081
Echinococcus granulosus cytoplasmic intermediate filament protein 0.007 0.018 0.0175
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0011 0.0091
Echinococcus granulosus expressed protein 0.0036 0.0068 0.0064
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0047
Plasmodium vivax glutathione reductase, putative 0.0037 0.0071 0.1191
Entamoeba histolytica dual specificity protein phosphatase, putative 0.0564 0.1816 0.4644
Mycobacterium ulcerans 6-phosphofructokinase 0.023 0.0711 0.3762
Brugia malayi hypothetical protein 0.0021 0.002 0.0041
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0119 0.205
Onchocerca volvulus 0.0056 0.0136 0.0246
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0047 0.0105 0.5827
Plasmodium falciparum von Willebrand factor A domain-related protein 0.0056 0.0136 0.7593
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0093 0.0258 0.1318
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0021 0.0018 0.0193
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0121 0.0349 0.1839
Echinococcus granulosus dna polymerase kappa 0.0019 0.0011 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0047 0.0104 0.024
Echinococcus granulosus intermediate filament protein 0.0144 0.0427 0.0422
Echinococcus granulosus ATP dependent DNA helicase Q5 0.003 0.005 0.0045
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0047 0.0104 0.0246
Echinococcus granulosus tm gpcr rhodopsin 0.0021 0.002 0.0016
Loa Loa (eye worm) hypothetical protein 0.0067 0.0171 0.0405
Echinococcus granulosus aldehyde dehydrogenase family 3 member B1 0.0021 0.0018 0.0014
Brugia malayi hypothetical protein 0.0041 0.0086 0.0198
Echinococcus granulosus survival motor neuron protein 1 0.026 0.0809 0.0805
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0047
Echinococcus multilocularis dnaJ subfamily B 0.0439 0.1403 0.14
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0093 0.0258 0.1318
Schistosoma mansoni ATP-binding cassette transporter 0.0025 0.0031 0.0033
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0104 0.0292 0.3147
Leishmania major mitochondrial DNA polymerase beta 0.0294 0.0922 0.7652
Brugia malayi hypothetical protein 0.0025 0.0031 0.0066
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 0.0021 0.0018 0.0037
Brugia malayi von Willebrand factor type A domain containing protein 0.0056 0.0136 0.0316
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0049
Loa Loa (eye worm) hypothetical protein 0.01 0.028 0.0663
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0011 0.0007
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0021 0.0018 0.0193
Schistosoma mansoni 6-phosphofructokinase 0.023 0.0711 0.0757
Echinococcus multilocularis sex peptide receptor 0.0021 0.002 0.0016
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0121 0.0349 0.2881
Entamoeba histolytica hypothetical protein 0.0047 0.0105 0.0268
Echinococcus granulosus dnaJ subfamily B 0.0439 0.1403 0.14
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0104 0.0292 0.2408
Schistosoma mansoni hypothetical protein 0.0021 0.002 0.0022
Trichomonas vaginalis phosphofructokinase, putative 0.0062 0.0155 0.03
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0021 0.002 0.0022
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0186 0.0564 0.0601
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1196 0.3909 0.8143
Brugia malayi Melatonin receptor type 1A 0.0021 0.002 0.0041
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0076 0.0111
Loa Loa (eye worm) hypothetical protein 0.0022 0.0022 0.0051
Onchocerca volvulus 0.0144 0.0427 0.0854
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0011 0.0045
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.0249 0.0774 0.0825
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0021 0.002 0.0022
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0047 0.0104 0.01
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0041 0.0086 0.0092
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.023 0.0711 0.3711
Echinococcus granulosus tar DNA binding protein 0.0063 0.0157 0.0152
Brugia malayi Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor 0.0021 0.0018 0.0036
Schistosoma mansoni histamine h1 receptor 0.0021 0.002 0.0022
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.002 0.0022
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0047
Trichomonas vaginalis CMGC family protein kinase 0.0104 0.0292 0.0587
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0119 0.6624
Plasmodium falciparum thioredoxin reductase 0.0037 0.0071 0.3849
Schistosoma mansoni glutamate receptor kainate 0.0025 0.0031 0.0033
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0047
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0047 0.0104 0.0111
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0021 0.002 0.0022
Echinococcus multilocularis voltage dependent calcium channel subunit 0.3035 1 1
Schistosoma mansoni DNA helicase recq5 0.003 0.005 0.0053
Onchocerca volvulus 0.0021 0.002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0056 0.0136 0.0322
Loa Loa (eye worm) PXA domain-containing protein 0.0041 0.0086 0.0203
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0056 0.0136 0.0316
Trichomonas vaginalis DNA helicase recq1, putative 0.0043 0.0093 0.017
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0079 0.0211 0.0207
Echinococcus multilocularis pyruvate kinase 0.0026 0.0034 0.003
Schistosoma mansoni opsin-like receptor 0.0021 0.002 0.0022
Echinococcus multilocularis somatostatin receptor 0.0021 0.002 0.0016
Loa Loa (eye worm) hypothetical protein 0.0047 0.0104 0.0246
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0021 0.002 0.0016
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0047
Echinococcus multilocularis neuropeptide s receptor 0.0021 0.002 0.0016
Loa Loa (eye worm) hypothetical protein 0.0025 0.0031 0.0072
Echinococcus multilocularis expressed protein 0.0805 0.2615 0.2611
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0076 0.0822
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0042
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0042 0.0089 0.0211
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0186 0.0564 0.4685
Entamoeba histolytica hypothetical protein 0.0037 0.0073 0.0184
Brugia malayi nuclear receptor NHR-88 0.0047 0.0104 0.024
Schistosoma mansoni aldehyde dehydrogenase 0.0021 0.0018 0.0019
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0115 0.033 0.0326
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0042
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0047 0.0104 0.01
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0047
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.01 0.028 0.0275
Loa Loa (eye worm) hypothetical protein 0.007 0.018 0.0425
Loa Loa (eye worm) hypothetical protein 0.0056 0.0136 0.0322
Schistosoma mansoni blooms syndrome DNA helicase 0.0028 0.0041 0.0044
Trypanosoma brucei trypanothione reductase 0.0037 0.0071 0.0741
Loa Loa (eye worm) hypothetical protein 0.0056 0.0136 0.0322
Echinococcus granulosus allatostatin A receptor 0.0021 0.002 0.0016
Echinococcus multilocularis glutamate receptor 2 0.007 0.0182 0.0178
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0089 0.0095
Schistosoma mansoni hypothetical protein 0.0021 0.002 0.0022
Mycobacterium ulcerans pyruvate kinase 0.0032 0.0057 0.0285
Echinococcus multilocularis pyruvate kinase 0.0032 0.0057 0.0052
Loa Loa (eye worm) hypothetical protein 0.0043 0.0091 0.0216
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0021 0.002 0.0004
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0091 0.0987
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0021 0.0018 0.0193
Loa Loa (eye worm) hypothetical protein 0.0022 0.0022 0.0051
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.002 0.0016
Echinococcus granulosus transcription factor btf3 0.0069 0.0178 0.0173
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0021 0.002 0.0022
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0022 0.0022 0.0018
Onchocerca volvulus 0.0021 0.002 0.0004
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0091 0.0987
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0047 0.0104 0.01
Echinococcus multilocularis PHD finger protein rhinoceros 0.0022 0.0021 0.0017
Echinococcus multilocularis regulator of G protein signaling 7 0.0041 0.0086 0.0082
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase 0.0021 0.0018 0.0081
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0021 0.0018 0.0045
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0041 0.0086 0.0082
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0021 0.0018 0.0193
Echinococcus granulosus regulator of G protein signaling 3 0.0041 0.0086 0.0082
Loa Loa (eye worm) hypothetical protein 0.0056 0.0136 0.0322
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0047
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0294 0.0922 1
Echinococcus multilocularis excitatory amino acid transporter 2 0.0249 0.0774 0.077
Loa Loa (eye worm) excitatory amino acid transporter 0.0249 0.0774 0.1838
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0022 0.0021 0.0017
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0045
Echinococcus multilocularis axis inhibition protein axin 0.0041 0.0086 0.0082
Mycobacterium tuberculosis Possible succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD2 0.0021 0.0018 0.0037
Echinococcus granulosus beta-adrenergic receptor kinase 0.0042 0.0089 0.0085
Echinococcus granulosus glutamate receptor subunit protein glur 0.0051 0.0118 0.0114
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0021 0.002 0.0022
Brugia malayi hypothetical protein 0.0025 0.0031 0.0066
Echinococcus granulosus sex peptide receptor 0.0021 0.002 0.0016
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0011 0.0118
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0019 0.0267
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0119 0.1288
Toxoplasma gondii NADP-dependent succinate-semialdehyde dehydrogenase 0.0021 0.0018 0.0148
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0091 0.0963
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1196 0.3909 1
Trichomonas vaginalis CMGC family protein kinase 0.0104 0.0292 0.0587
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0084 0.0227 0.1152
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0021 0.0018 0.0166
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0047
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0047 0.0104 0.0111
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0026
Loa Loa (eye worm) hypothetical protein 0.0041 0.0086 0.0203
Schistosoma mansoni microtubule-associated protein tau 0.2849 0.9383 1
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0038 0.0075 0.007
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.002 0.0016
Trichomonas vaginalis phosphofructokinase, putative 0.023 0.0711 0.1461
Brugia malayi hypothetical protein 0.0021 0.0019 0.0039
Onchocerca volvulus 0.0022 0.0022 0.0008
Toxoplasma gondii methylmalonate-semialdehyde dehydrogenase [acylating], putative 0.0021 0.0018 0.0148
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0047
Schistosoma mansoni nuclear receptor nhr-48 0.0022 0.0022 0.0024
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0011 0.002
Brugia malayi Succinate semialdehyde dehydrogenase, mitochondrial precursor 0.0021 0.0018 0.0036
Echinococcus granulosus g protein coupled receptor 0.0021 0.002 0.0016
Trichomonas vaginalis pyruvate kinase, putative 0.0032 0.0057 0.0095
Plasmodium vivax 6-phosphofructokinase, putative 0.0062 0.0155 0.2689
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0086 0.0156
Brugia malayi hypothetical protein 0.0021 0.002 0.0041
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0024 0.0056
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0047 0.0104 0.0111
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0047 0.0104 0.024
Echinococcus multilocularis ecdysone induced protein 78C 0.0047 0.0104 0.01
Echinococcus granulosus ATP dependent DNA helicase Q1 0.003 0.005 0.0045
Mycobacterium tuberculosis Probable reductase 0.0084 0.0227 0.1152
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0021 0.002 0.0047
Loa Loa (eye worm) CYP4Cod1 0.0016 0.0003 0.0006
Echinococcus granulosus expressed protein 0.0805 0.2615 0.2611
Onchocerca volvulus 0.0021 0.0019 0.0002
Brugia malayi hypothetical protein 0.026 0.0809 0.1916
Toxoplasma gondii PHD-finger domain-containing protein 0.0022 0.0021 0.0173
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0047
Brugia malayi F/Y-rich N-terminus family protein 0.0032 0.0056 0.0127
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0022 0.0021 0.0017
Onchocerca volvulus 0.0056 0.0136 0.0246
Onchocerca volvulus 0.0021 0.002 0.0004
Echinococcus granulosus PHD finger protein rhinoceros 0.0022 0.0021 0.0017
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0038 0.0075 0.007
Giardia lamblia Fructose-bisphosphate aldolase 0.1196 0.3909 1
Onchocerca volvulus 0.0022 0.0022 0.0008
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0027 0.004 0.0094
Echinococcus multilocularis sodium:dicarboxylate symporter 0.011 0.0315 0.0311
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0011 0.0091
Brugia malayi Pyruvate kinase, M2 isozyme 0.0032 0.0057 0.0128
Loa Loa (eye worm) hypothetical protein 0.0168 0.0504 0.1196
Echinococcus multilocularis G protein coupled receptor 139 0.0021 0.002 0.0016
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0047
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0115 0.033 0.0326
Brugia malayi G protein-coupled receptor 0.0021 0.002 0.0041
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.002 0.0022
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.0003 0.0027
Schistosoma mansoni DNA polymerase eta 0.0019 0.0011 0.0012
Chlamydia trachomatis glutamate symporter 0.0249 0.0774 1
Echinococcus granulosus G protein coupled receptor 139 0.0021 0.002 0.0016
Brugia malayi hypothetical protein 0.0051 0.0119 0.0276
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0011 0.0007
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0379 0.1204 0.12
Brugia malayi Cytochrome P450 family protein 0.0026 0.0036 0.0079
Brugia malayi Doublecortin family protein 0.0021 0.0019 0.0039
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0086 0.0928
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0041 0.0084 0.4585
Echinococcus multilocularis neuropeptide receptor A26 0.0021 0.002 0.0016
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0047 0.0105 0.0871
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0047
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0076 0.0347
Brugia malayi glutathione reductase 0.0037 0.0071 0.0162
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0119 0.0986
Echinococcus granulosus nuclear receptor nhr 48 0.0022 0.0022 0.0018
Giardia lamblia Pyruvate kinase 0.0032 0.0057 0.0134
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0047 0.0105 0.0678
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0584 0.1884 1
Echinococcus multilocularis regulator of G protein signaling 0.0041 0.0086 0.0082
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0047
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.023 0.0711 0.1042
Brugia malayi von Willebrand factor type A domain containing protein 0.0056 0.0136 0.0316
Loa Loa (eye worm) hypothetical protein 0.0341 0.1077 0.2557
Trypanosoma cruzi pyruvate kinase 2, putative 0.0032 0.0057 0.061
Echinococcus multilocularis microtubule associated protein 2 0.2849 0.9383 0.9383
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0047 0.0105 0.1151
Trichomonas vaginalis set domain proteins, putative 0.1464 0.4798 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0086 0.0928
Brugia malayi orphan nuclear receptor NR2E1 0.0022 0.0022 0.0046
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0047
Echinococcus granulosus g-protein coupled receptor 0.0021 0.002 0.0016
Schistosoma mansoni jumonji domain containing protein 0.0057 0.0137 0.0146
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0011 0.0026
Onchocerca volvulus 0.0021 0.002 0.0004
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0011 0.0012
Brugia malayi Zona pellucida-like domain containing protein 0.0056 0.0136 0.0316
Brugia malayi G-protein coupled receptor 0.0021 0.002 0.0041
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0047 0.0104 0.0179
Echinococcus granulosus GPCR family 2 0.0048 0.0108 0.0104
Onchocerca volvulus Excitatory amino acid transporter homolog 0.0249 0.0774 0.1581
Schistosoma mansoni thyroid hormone receptor 0.0312 0.0983 0.1048
Schistosoma mansoni hypothetical protein 0.0037 0.0073 0.0077
Leishmania major DNA polymerase kappa, putative 0.0019 0.0011 0.007
Brugia malayi regulator of G-protein signaling rgs-7 0.0041 0.0086 0.0198
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1196 0.3909 0.8143
Toxoplasma gondii NAC domain-containing protein 0.0069 0.0178 0.1472
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0021 0.002 0.0041
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0271 0.0845 0.2006
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0045
Echinococcus multilocularis g-protein coupled receptor 0.0021 0.002 0.0016
Schistosoma mansoni alpha-1 adrenergic receptor 0.0021 0.002 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0091 0.0167
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0025 0.0034 0.0029
Schistosoma mansoni succinate semialdehyde dehydrogenase 0.0021 0.0018 0.0019
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0011 0.0091
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0011 0.0118
Treponema pallidum fructose-bisphosphate aldolase 0.1196 0.3909 0.5733
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0022 0.0022 0.0008
Echinococcus granulosus neuropeptide receptor A26 0.0021 0.002 0.0016
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0038 0.0075 0.007
Schistosoma mansoni nuclear receptor 0.0022 0.0022 0.0024
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0076 0.018
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.003 0.005 0.0111
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0104 0.0292 0.0693
Onchocerca volvulus 0.0056 0.0136 0.0246
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0011 0.0012
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0047
Schistosoma mansoni axis inhibition protein axin 0.0041 0.0086 0.0092
Echinococcus granulosus neutral amino acid transporter A 0.0249 0.0774 0.077
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0108 0.0104
Toxoplasma gondii gamma-glutamyl phosphate reductase, putative 0.0021 0.0018 0.0148
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0065 0.0702
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0022 0.0021 0.0023
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0004 0.0032
Loa Loa (eye worm) RNA binding protein 0.0063 0.0157 0.0371
Onchocerca volvulus 0.0053 0.0125 0.0223
Brugia malayi Nuclear hormone receptor E75 0.0022 0.0022 0.0046
Loa Loa (eye worm) CUTiclin-Like family member 0.0056 0.0136 0.0322
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0021 0.0018 0.0193
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0021 0.0018 0.0014
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0022 0.0022 0.0008
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0019 0.0015
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0043 0.0091 0.021
Echinococcus multilocularis lamin 0.0144 0.0427 0.0422
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0294 0.0922 1
Echinococcus granulosus L aminoadipate semialdehyde 0.0168 0.0504 0.05
Echinococcus granulosus tumor protein p63 0.035 0.1108 0.1104
Echinococcus granulosus tm gpcr rhodopsin 0.0021 0.002 0.0016
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0022 0.0022 0.0024
Echinococcus granulosus succinate semialdehyde dehydrogenase 0.0021 0.0018 0.0014
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.003 0.005 0.2623
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0379 0.1204 1
Echinococcus granulosus excitatory amino acid transporter 3 0.0249 0.0774 0.077
Toxoplasma gondii phosphofructokinase PFKII 0.0062 0.0155 0.1283
Trichomonas vaginalis phosphofructokinase, putative 0.023 0.0711 0.1461
Brugia malayi nuclear receptor RXR 0.0025 0.0031 0.0066
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0047
Echinococcus multilocularis muscleblind protein 0.0143 0.0424 0.0419
Mycobacterium ulcerans gamma-glutamyl phosphate reductase 0.0021 0.0018 0.0081
Echinococcus granulosus Excitatory amino acid transporter 0.0249 0.0774 0.077
Mycobacterium tuberculosis Conserved hypothetical protein 0.0155 0.0461 0.2404
Onchocerca volvulus 0.0021 0.002 0.0004
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1287 0.421 1
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0022 0.0024
Echinococcus multilocularis cpg binding protein 0.0064 0.0161 0.0157
Echinococcus granulosus neutral amino acid transporter 0.0249 0.0774 0.077
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0047
Echinococcus multilocularis fmrfamide receptor 0.0021 0.002 0.0016
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0011 0.0091
Loa Loa (eye worm) neuropeptide F receptor 0.0021 0.002 0.0047
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0011 0.002
Loa Loa (eye worm) histone methyltransferase 0.0025 0.0034 0.0079
Loa Loa (eye worm) jmjC domain-containing protein 0.003 0.0048 0.0113
Brugia malayi hypothetical protein 0.0033 0.0059 0.0133
Schistosoma mansoni 6-phosphofructokinase 0.023 0.0711 0.0757
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0062 0.0155 0.1283
Schistosoma mansoni DNA helicase recq1 0.003 0.005 0.0053
Schistosoma mansoni regulator of G protein signaling 0.0041 0.0086 0.0092
Schistosoma mansoni opsin-like receptor 0.0021 0.002 0.0022
Echinococcus multilocularis glutamate receptor 2 0.0067 0.017 0.0165
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0121 0.0349 0.1803
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0089 0.0095
Schistosoma mansoni lamin 0.0144 0.0427 0.0455
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0011 0.0091
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0021 0.0018 0.0193
Schistosoma mansoni amine GPCR 0.0021 0.002 0.0022
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0021 0.0018 0.0193
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0021 0.002 0.0016
Echinococcus multilocularis mitogen activated protein kinase 3 0.0104 0.0292 0.0288
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.002 0.0016
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0076 0.0072
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0168 0.0504 0.1191
Toxoplasma gondii hypothetical protein 0.0047 0.0106 0.0878
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0265 0.0828 0.0824
Onchocerca volvulus 0.0021 0.002 0.0004
Schistosoma mansoni neuropeptide receptor 0.0021 0.002 0.0022
Schistosoma mansoni aldehyde dehydrogenase 0.0021 0.0018 0.0019
Brugia malayi nuclear hormone receptor 0.0022 0.0022 0.0046
Echinococcus granulosus muscleblind protein 0.0143 0.0424 0.0419
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.0056 0.0136 0.1125
Schistosoma mansoni nuclear hormone receptor 0.0047 0.0104 0.0111
Echinococcus multilocularis neutral amino acid transporter A 0.0249 0.0774 0.077
Brugia malayi jmjC domain containing protein 0.003 0.0048 0.0107
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.01 0.028 0.0298
Loa Loa (eye worm) glutamate receptor 0.0093 0.0259 0.0613
Trypanosoma brucei protein kinase, putative 0.0104 0.0292 0.3147
Trichomonas vaginalis phosphofructokinase, putative 0.0062 0.0155 0.03
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0022 0.0022 0.0018
Echinococcus multilocularis muscleblind protein 1 0.0143 0.0424 0.0419
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0047 0.0104 0.01
Echinococcus granulosus dna polymerase eta 0.0019 0.0011 0.0007
Echinococcus multilocularis mitogen activated protein kinase 0.0104 0.0292 0.0288
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0022 0.0022 0.0018
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0047
Mycobacterium leprae conserved hypothetical protein 0.0047 0.0105 0.0467
Echinococcus granulosus lysine specific demethylase 5A 0.003 0.0048 0.0044
Echinococcus granulosus regulator of G protein signaling 7 0.0041 0.0086 0.0082
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.002 0.0016
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0062 0.0155 0.0227
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0071 0.0766
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0021 0.002 0.0016
Brugia malayi Dopamine receptor protein 1 0.0021 0.002 0.0041
Treponema pallidum hypothetical protein 0.0056 0.0136 0.0199
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0047 0.0104 0.0246
Brugia malayi tailless protein 0.0022 0.0022 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0047 0.0104 0.024
Schistosoma mansoni glutamate receptor kainate 0.0025 0.0031 0.0033
Trichomonas vaginalis DNA helicase recq, putative 0.0043 0.0093 0.017
Loa Loa (eye worm) hypothetical protein 0.0114 0.0327 0.0775
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0047 0.0105 0.0502
Loa Loa (eye worm) hypothetical protein 0.0047 0.0104 0.0246
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0249 0.0774 0.077
Loa Loa (eye worm) hypothetical protein 0.0142 0.0418 0.0991
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0011 0.0091
Schistosoma mansoni amine GPCR 0.0021 0.002 0.0022
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0047
Loa Loa (eye worm) hypothetical protein 0.0056 0.0136 0.0322
Brugia malayi hypothetical protein 0.0021 0.0019 0.0039
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0186 0.0564 0.0601
Echinococcus granulosus glutamate receptor 2 0.008 0.0213 0.0208
Loa Loa (eye worm) ATP-dependent DNA helicase 0.003 0.005 0.0117
Loa Loa (eye worm) hypothetical protein 0.0186 0.0564 0.1339
Echinococcus granulosus ecdysone induced protein 78C 0.0047 0.0104 0.01
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0084 0.0227 0.1152
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.01 0.028 0.0298
Echinococcus multilocularis peregrin 0.0022 0.0021 0.0017
Trichomonas vaginalis phosphofructokinase, putative 0.023 0.0711 0.1461
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0021 0.002 0.0016
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0011 0.0091
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0104 0.0292 0.3166
Echinococcus granulosus lamin 0.0144 0.0427 0.0422
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0041 0.0086 0.0092
Mycobacterium ulcerans aldehyde dehydrogenase 0.0379 0.1204 0.6384
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0021 0.002 0.0016
Onchocerca volvulus 0.0056 0.0136 0.0246
Loa Loa (eye worm) melatonin receptor type 1A 0.0021 0.002 0.0047
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0057 0.008
Brugia malayi hypothetical protein 0.0037 0.0073 0.0165
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0022 0.0024
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0047
Leishmania major phosphopantetheinyl transferase-like protein 0.0047 0.0105 0.0852
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.0003 0.0027
Schistosoma mansoni cpg binding protein 0.006 0.015 0.0159
Echinococcus granulosus excitatory amino acid transporter 2 0.0249 0.0774 0.077
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0379 0.1204 0.6368
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0057 0.0133
Loa Loa (eye worm) hypothetical protein 0.0047 0.0104 0.0246
Mycobacterium tuberculosis Probable gamma-glutamyl phosphate reductase protein ProA (GPR) (glutamate-5-semialdehyde dehydrogenase) (glutamyl-gamma-semialde 0.0021 0.0018 0.0037
Echinococcus granulosus histone lysine methyltransferase setb 0.0186 0.0564 0.056
Schistosoma mansoni aldehyde dehydrogenase 0.0021 0.0018 0.0019
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0021 0.002 0.0016
Schistosoma mansoni coup transcription factor 0.0047 0.0104 0.0111
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0021 0.002 0.0016
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.023 0.0711 0.7702
Loa Loa (eye worm) neuropeptide F receptor 0.0021 0.002 0.0047
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0062 0.0155 0.8692
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0076 0.0822
Mycobacterium ulcerans aldehyde dehydrogenase 0.0379 0.1204 0.6384
Trypanosoma cruzi transcription factor btf3, putative 0.0069 0.0178 0.1922
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0047
Schistosoma mansoni opsin-like receptor 0.0021 0.002 0.0022
Brugia malayi RNA binding protein 0.0063 0.0157 0.0365
Trichomonas vaginalis CMGC family protein kinase 0.0104 0.0292 0.0587
Loa Loa (eye worm) hypothetical protein 0.0611 0.1973 0.4685
Treponema pallidum glutamate transporter 0.011 0.0315 0.0461
Echinococcus granulosus microtubule associated protein 2 0.2849 0.9383 0.9383
Toxoplasma gondii PHD-finger domain-containing protein 0.0022 0.0021 0.0173
Schistosoma mansoni biogenic amine receptor 0.0021 0.002 0.0022
Schistosoma mansoni thyroid hormone receptor 0.0312 0.0983 0.1048
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0043 0.0091 0.0097
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0108 0.025
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0021 0.002 0.0041
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0047
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0025 0.0021
Echinococcus multilocularis betaine aldehyde dehydrogenase 0.0021 0.0018 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0047 0.0104 0.024
Brugia malayi Nuclear hormone receptor-like 1 0.0025 0.0031 0.0066
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0062 0.0155 0.8692
Brugia malayi von Willebrand factor type A domain containing protein 0.0056 0.0136 0.0316
Brugia malayi latrophilin 2 splice variant baaae 0.0104 0.0293 0.0689
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0125 0.0289
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0086 0.0156
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.0056 0.0136 0.0322
Brugia malayi Steroid receptor seven-up type 2 0.0047 0.0104 0.024
Echinococcus granulosus somatostatin receptor 0.0021 0.002 0.0016
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0021 0.002 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0047 0.0104 0.024
Schistosoma mansoni hypothetical protein 0.0053 0.0125 0.0133
Schistosoma mansoni glutamate receptor AMPA 0.0025 0.0031 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0047 0.0104 0.024
Echinococcus granulosus biogenic amine 5HT receptor 0.0021 0.002 0.0016
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0047
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0057 0.008
Entamoeba histolytica hypothetical protein 0.0041 0.0086 0.0219
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0294 0.0922 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0021 0.002 0.0016
Onchocerca volvulus 0.0051 0.0119 0.021
Echinococcus multilocularis neuropeptides capa receptor 0.0021 0.002 0.0016
Brugia malayi Pre-SET motif family protein 0.1287 0.421 1
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0019 0.0015
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.0091 0.0167
Plasmodium vivax 6-phosphofructokinase, putative 0.0062 0.0155 0.2689
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.002 0.0022
Onchocerca volvulus 0.1464 0.4798 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0036 0.0085
Loa Loa (eye worm) hypothetical protein 0.0022 0.0022 0.0051
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0043 0.0091 0.0233
Trichomonas vaginalis CMGC family protein kinase 0.0104 0.0292 0.0587
Loa Loa (eye worm) RecQ helicase 0.0043 0.0093 0.0219
Schistosoma mansoni neuropeptide receptor 0.0021 0.002 0.0022
Loa Loa (eye worm) glutamate receptor 0.0035 0.0065 0.0153
Loa Loa (eye worm) hypothetical protein 0.0041 0.0086 0.0203
Loa Loa (eye worm) hypothetical protein 0.0047 0.0104 0.0246
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0178 0.0347
Mycobacterium ulcerans pyrroline-5-carboxylate dehydrogenase, RocA 0.0021 0.0018 0.0081
Brugia malayi Kringle domain containing protein 0.0022 0.0022 0.0045
Giardia lamblia Alcohol dehydrogenase 0.0021 0.0018 0.0036
Onchocerca volvulus 0.0021 0.002 0.0004
Toxoplasma gondii aldehyde dehydrogenase (NAD) family protein 0.0021 0.0018 0.0148
Brugia malayi hypothetical protein 0.0021 0.002 0.0041
Echinococcus granulosus neuropeptides capa receptor 0.0021 0.002 0.0016
Brugia malayi hypothetical protein 0.0022 0.0022 0.0046
Echinococcus multilocularis thyroid hormone receptor alpha 0.0312 0.0983 0.0979
Loa Loa (eye worm) hypothetical protein 0.0144 0.0427 0.1012
Trichomonas vaginalis DNA helicase recq, putative 0.0033 0.0059 0.0099
Schistosoma mansoni hypothetical protein 0.0021 0.002 0.0022
Brugia malayi PXA domain containing protein 0.0041 0.0086 0.0198
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0047 0.0104 0.01
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0021 0.0018 0.0166
Loa Loa (eye worm) hypothetical protein 0.0041 0.0086 0.0203
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0033 0.0059 0.0464
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0121 0.0349 0.0345
Echinococcus granulosus geminin 0.0363 0.1153 0.1149
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0027 0.004 0.0094
Echinococcus granulosus hypothetical protein 0.0021 0.002 0.0016
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.0056 0.0136 0.2349
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0047 0.0104 0.01
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0157 0.0167
Loa Loa (eye worm) hypothetical protein 0.0023 0.0024 0.0056
Echinococcus granulosus leukotriene A 4 hydrolase 0.0231 0.0714 0.0709
Brugia malayi Receptor family ligand binding region containing protein 0.0027 0.004 0.0088
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.089 0.2898 0.2895
Brugia malayi Metabotropic glutamate receptor precursor. 0.0093 0.0259 0.0608
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0021 0.0303
Leishmania major pyruvate kinase 0.0032 0.0057 0.0447
Echinococcus multilocularis neuropeptides capa receptor 0.0021 0.002 0.0016
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.002 0.0016
Trypanosoma brucei hypothetical protein, conserved 0.0047 0.0105 0.1113
Echinococcus multilocularis beta adrenergic receptor kinase 0.0042 0.0089 0.0085
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0186 0.0564 0.056
Echinococcus granulosus 7TM GPCR rhodopsin 0.0021 0.002 0.0016
Onchocerca volvulus 0.0022 0.0022 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0047 0.0104 0.024
Brugia malayi follicle stimulating hormone receptor 0.0271 0.0845 0.2002
Schistosoma mansoni biogenic amine (5HT) receptor 0.0021 0.002 0.0022
Entamoeba histolytica recQ family helicase, putative 0.0033 0.0059 0.0149
Brugia malayi hypothetical protein 0.0021 0.002 0.0041
Schistosoma mansoni intermediate filament proteins 0.0144 0.0427 0.0455
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0047 0.0104 0.0246
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0026 0.0034 0.0538
Loa Loa (eye worm) POT family protein 0.0087 0.0239 0.0566
Brugia malayi AKH receptor 0.0021 0.002 0.0041
Leishmania major aldehyde dehydrogenase, putative 0.0021 0.0018 0.0127
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0076 0.061
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0011 0.0091
Echinococcus multilocularis dna polymerase eta 0.0019 0.0011 0.0007
Mycobacterium tuberculosis Probable aldehyde dehydrogenase (NAD+) dependent 0.0021 0.0018 0.0037
Schistosoma mansoni hypothetical protein 0.0265 0.0828 0.0883
Brugia malayi von Willebrand factor type A domain containing protein 0.0056 0.0136 0.0316
Echinococcus multilocularis GPCR, family 2 0.0048 0.0108 0.0104
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0022 0.0022 0.0046
Echinococcus multilocularis serotonin receptor 0.0021 0.002 0.0016
Onchocerca volvulus 0.0168 0.0504 0.1016
Echinococcus multilocularis geminin 0.0363 0.1153 0.1149
Schistosoma mansoni glutamate receptor NMDA 0.0025 0.0031 0.0033
Brugia malayi cytoplasmic intermediate filament protein 0.0077 0.0205 0.048
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0168 0.0504 0.0537
Brugia malayi Bloom's syndrome protein homolog 0.0043 0.0093 0.0213
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0021 0.0018 0.0193
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0157 0.0371
Echinococcus multilocularis collagen alpha 1(VII) chain 0.0056 0.0136 0.0132
Onchocerca volvulus 0.0021 0.002 0.0004
Brugia malayi aldehyde dehydrogenase 0.0021 0.0018 0.0036
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0038 0.0075 0.007
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0047 0.0104 0.024
Brugia malayi hypothetical protein 0.0021 0.002 0.0041
Brugia malayi Dopamine receptor protein 2 0.0021 0.002 0.0041
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0047
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0042 0.0089 0.0211
Loa Loa (eye worm) hypothetical protein 0.0152 0.0452 0.1072
Toxoplasma gondii exonuclease III APE 0.0038 0.0076 0.063
Echinococcus granulosus neuropeptide receptor 0.0021 0.002 0.0016
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0047
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.1324 0.4334 0.4619
Echinococcus granulosus regulator of G protein signaling 7 0.0041 0.0086 0.0082
Brugia malayi Immunoglobulin I-set domain containing protein 0.0056 0.0136 0.0316
Brugia malayi nuclear receptor RXR 0.0022 0.0022 0.0046
Loa Loa (eye worm) hypothetical protein 0.0022 0.0022 0.0051
Echinococcus granulosus bloom syndrome protein 0.0043 0.0093 0.0088
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0011 0.0091
Onchocerca volvulus Neuropeptide F receptor homolog 0.0021 0.002 0.0004
Entamoeba histolytica hypothetical protein 0.0056 0.0136 0.0346
Brugia malayi von Willebrand factor type A domain containing protein 0.0056 0.0136 0.0316
Echinococcus granulosus mitogen activated protein kinase 0.0104 0.0292 0.0288
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0019 0.0015
Brugia malayi RE15519p 0.0021 0.002 0.0041
Brugia malayi hypothetical protein 0.0041 0.0086 0.0198
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.002 0.0016
Loa Loa (eye worm) hypothetical protein 0.0056 0.0136 0.0322
Schistosoma mansoni glutamate receptor NMDA 0.0038 0.0075 0.0079
Brugia malayi Intermediate filament tail domain containing protein 0.0144 0.0427 0.1007
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.003 0.005 0.041
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0135 0.0396 0.0423
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0021 0.002 0.0016
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0003 0.0006
Plasmodium falciparum thrombospondin-related anonymous protein 0.0056 0.0136 0.7593
Brugia malayi Serotonin receptor 0.0021 0.002 0.0041
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0021 0.002 0.0016
Brugia malayi Thioredoxin reductase 0.0037 0.0071 0.0162
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0011 0.0045
Mycobacterium ulcerans methylmalonate semialdehyde dehydrogenase, MmsA 0.0021 0.0018 0.0081
Onchocerca volvulus 0.0186 0.0564 0.1142
Schistosoma mansoni nuclear receptor 0.0022 0.0022 0.0024
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0047 0.0104 0.024
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0047 0.0104 0.01
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0086 0.0928
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0119 0.6624
Trichomonas vaginalis phosphofructokinase, putative 0.0062 0.0155 0.03
Echinococcus granulosus neuropeptide Y receptor 0.0021 0.002 0.0016
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0038 0.0075 0.007
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0011 0.0091
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0157 0.0365
Schistosoma mansoni regulator of G protein signaling 0.0041 0.0086 0.0092
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0033 0.0059 0.0606
Loa Loa (eye worm) hypothetical protein 0.0051 0.0119 0.0282
Echinococcus granulosus metabotropic glutamate receptor 2 0.0079 0.0211 0.0207
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0139 0.0409 0.4424
Loa Loa (eye worm) hypothetical protein 0.0042 0.0087 0.0207
Loa Loa (eye worm) CXXC zinc finger family protein 0.006 0.015 0.0354
Schistosoma mansoni biogenic amine (5HT) receptor 0.0021 0.002 0.0022
Trypanosoma brucei unspecified product 0.0019 0.0011 0.0091
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0116 0.1253
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0022 0.0235
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0068 0.0118
Plasmodium falciparum glutathione reductase 0.0037 0.0071 0.3849
Schistosoma mansoni neuropeptide receptor 0.0021 0.002 0.0022
Giardia lamblia DINP protein human, muc B family 0.0019 0.0011 0.0018
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0119 0.1264
Echinococcus multilocularis Excitatory amino acid transporter 0.0249 0.0774 0.077
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0115 0.033 0.0326
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0047
Schistosoma mansoni serine-rich repeat protein 0.0713 0.231 0.2462
Loa Loa (eye worm) G-protein coupled receptor 0.0021 0.002 0.0047
Brugia malayi Nuclear hormone receptor E75 0.0022 0.0022 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0178 0.0347
Echinococcus multilocularis bloom syndrome protein 0.0043 0.0093 0.0088
Schistosoma mansoni regulator of G protein signaling 0.0041 0.0086 0.0092
Echinococcus multilocularis musashi 0.0144 0.0427 0.0422
Schistosoma mansoni biogenic amine receptor 0.0021 0.002 0.0022
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.002 0.0016
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0076 0.0174
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0071 0.1191
Mycobacterium leprae Probable pyruvate kinase PykA 0.0032 0.0057 0.0206
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0157 0.0152
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0021 0.002 0.0047
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0025 0.0031 0.0033
Brugia malayi ecdysone receptor 0.0022 0.0022 0.0046
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0021 0.002 0.0016
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0051 0.0118 0.0114
Echinococcus multilocularis Regulator of G protein signaling 20 0.0041 0.0086 0.0082
Loa Loa (eye worm) hypothetical protein 0.0022 0.0022 0.0051
Mycobacterium ulcerans NAD-dependent aldehyde dehydrogenase AldA 0.0021 0.0018 0.0081
Brugia malayi Glutamate receptor 1 precursor 0.0067 0.017 0.0396
Echinococcus granulosus sodium:dicarboxylate symporter 0.0249 0.0774 0.077
Brugia malayi Tachykinin-like peptides receptor 99D 0.0021 0.002 0.0041
Loa Loa (eye worm) hypothetical protein 0.0056 0.0136 0.0322
Brugia malayi steroid hormone receptor 0.0047 0.0104 0.024
Toxoplasma gondii 6-phosphofructokinase 0.0062 0.0155 0.1283
Echinococcus multilocularis allatostatin A receptor 0.0021 0.002 0.0016
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0093 0.0258 0.1286
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0584 0.1884 1
Treponema pallidum gamma-glutamyl phosphate reductase 0.0021 0.0018 0.0026
Loa Loa (eye worm) 6-phosphofructokinase 0.023 0.0711 0.1687
Loa Loa (eye worm) hypothetical protein 0.0028 0.0043 0.0102
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0047 0.0104 0.0111
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.002 0.0022
Echinococcus multilocularis dro:myosuppressin receptor 0.0021 0.002 0.0016
Brugia malayi Excitatory amino acid transporter 0.0249 0.0774 0.1833
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0021 0.002 0.0022
Giardia lamblia Kinase, CMGC MAPK 0.0104 0.0292 0.0737
Entamoeba histolytica phosphofructokinase, putative 0.023 0.0711 0.1817
Brugia malayi A-kinase anchor protein 10, precursor 0.0041 0.0086 0.0198
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0231 0.0714 0.076
Echinococcus granulosus glutamate NMDA receptor subunit 0.0025 0.0031 0.0027
Trichomonas vaginalis succinate semialdehyde dehydrogenase, putative 0.0021 0.0018 0.0014
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.002 0.0016
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0047
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.008 0.0213 0.0208
Echinococcus multilocularis Fatty aldehyde dehydrogenase 0.0021 0.0018 0.0014
Schistosoma mansoni steroid hormone receptor ad4bp 0.0047 0.0104 0.0111
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0108 0.025
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0041 0.0086 0.0092
Echinococcus multilocularis jumonji domain containing protein 0.003 0.005 0.0045
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.01 0.028 0.0275
Schistosoma mansoni hypothetical protein 0.0048 0.0108 0.0115
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0062 0.0155 0.0395
Echinococcus granulosus metabotropic glutamate receptor 5 0.0114 0.0327 0.0322
Echinococcus granulosus Nuclear hormone receptor HR96 0.0022 0.0022 0.0018
Brugia malayi hypothetical protein 0.0022 0.0022 0.0046
Onchocerca volvulus 0.0021 0.002 0.0004
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0011 0.0007
Brugia malayi Aldehyde dehydrogenase protein 4 0.0021 0.0018 0.0036
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0022 0.0022 0.0024
Loa Loa (eye worm) hypothetical protein 0.0037 0.0073 0.0172
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.0056 0.0136 0.2349
Brugia malayi ORL1-like opioid receptor 0.0021 0.002 0.0041
Brugia malayi G-protein coupled receptor 0.0021 0.002 0.0041

Activities

Activity type Activity value Assay description Source Reference
Clp (ADMET) = 9.2 ml min-1 kg-1 Plasma clearance of the compound was determined in rats at the dose of 1.0 mpk by i.v. administration ChEMBL. 15177461
ED50 (functional) = 2.1 MPK Ability of the compound to lower circulating lymphocyte levels in mice after 3 hrs of intravenous administration ChEMBL. 15177461
ED50 (functional) = 2.1 MPK Ability of the compound to lower circulating lymphocyte levels in mice after 3 hrs of intravenous administration ChEMBL. 15177461
IC50 (binding) = 4.1 nM Binding affinity to human sphingosine 1-phosphate receptor 1 expressed in CHO cells was determined by using [33P]-S1P as radioligand ChEMBL. 15177461
IC50 (binding) = 4.1 nM Displacement of [33P]sphingosine 1 phosphate from human S1P1 receptor expressed in CHO cells ChEMBL. 15615513
IC50 (binding) = 4.1 nM Binding affinity to human sphingosine 1-phosphate receptor 1 expressed in CHO cells was determined by using [33P]-S1P as radioligand ChEMBL. 15177461
IC50 (binding) = 10 nM Binding affinity to human sphingosine 1-phosphate receptor 5 expressed in CHO cells was determined by using [33P]-S1P as radioligand ChEMBL. 15177461
IC50 (binding) = 10 nM Displacement of [33P]sphingosine 1 phosphate from human S1P5 receptor expressed in CHO cells ChEMBL. 15615513
IC50 (binding) = 10 nM Binding affinity to human sphingosine 1-phosphate receptor 5 expressed in CHO cells was determined by using [33P]-S1P as radioligand ChEMBL. 15177461
IC50 (binding) = 80 nM Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand ChEMBL. 15177461
IC50 (binding) = 80 nM Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells ChEMBL. 15615513
IC50 (binding) = 80 nM Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand ChEMBL. 15177461
IC50 (binding) = 2100 nM Binding affinity to human sphingosine 1-phosphate receptor 3 expressed in CHO cells was determined by using [33P]-S1P as radioligand ChEMBL. 15177461
IC50 (binding) = 2100 nM Displacement of [33P]sphingosine 1 phosphate from human S1P3 receptor expressed in CHO cells ChEMBL. 15615513
IC50 (binding) = 2100 nM Binding affinity to human sphingosine 1-phosphate receptor 3 expressed in CHO cells was determined by using [33P]-S1P as radioligand ChEMBL. 15177461
IC50 (binding) > 10000 nM Binding affinity to human sphingosine 1-phosphate receptor 2 expressed in CHO cells was determined by using [33P]-S1P as radioligand ChEMBL. 15177461
IC50 (binding) > 10000 nM Displacement of [33P]sphingosine 1 phosphate from human S1P2 receptor expressed in CHO cells ChEMBL. 15615513
IC50 (binding) > 10000 nM Binding affinity to human sphingosine 1-phosphate receptor 2 expressed in CHO cells was determined by using [33P]-S1P as radioligand ChEMBL. 15177461
IC50 (binding) > 10000 nM Displacement of [33P]sphingosine 1 phosphate from human S1P2 receptor expressed in CHO cells ChEMBL. 15615513
T1/2 (ADMET) = 2.1 hr Half life of the compound was determined in rats at the dose of 1.0 mpk by i.v. administration ChEMBL. 15177461
Vdss (ADMET) = 1.4 l kg-1 Volume of distribution in steady state was determined in rats at the dose of 1.0 mpk by i.v. administration ChEMBL. 15177461

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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