Detailed information for compound 236819

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 388.63 | Formula: C25H44N2O
  • H donors: 1 H acceptors: 1 LogP: 5.9 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)N[C@H]1CC[C@]2([C@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](N(C)C)C)C)C
  • InChi: 1S/C25H44N2O/c1-16(27(5)6)21-9-10-22-20-8-7-18-15-19(26-17(2)28)11-13-24(18,3)23(20)12-14-25(21,22)4/h16,18-23H,7-15H2,1-6H3,(H,26,28)/t16-,18-,19-,20-,21+,22-,23-,24-,25+/m0/s1
  • InChiKey: AIEKUSBFLBFTIU-MENSBAHOSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens butyrylcholinesterase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus granulosus acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus granulosus carboxylesterase 5A Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma japonicum Acetylcholinesterase 1 precursor, putative Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus multilocularis acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Brugia malayi Carboxylesterase family protein Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma japonicum ko:K01049 acetylcholinesterase [EC3.1.1.7], putative Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus multilocularis acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) acetylcholinesterase 1 Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) carboxylesterase Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus multilocularis carboxylesterase 5A Get druggable targets OG5_126875 All targets in OG5_126875
Brugia malayi Carboxylesterase family protein Get druggable targets OG5_126875 All targets in OG5_126875
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Carboxylesterase family protein butyrylcholinesterase 602 aa 546 aa 30.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0121 0.0117 0.0813
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0108 0.0102 0.0407
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0108 0.0102 0.0305
Plasmodium falciparum DNA topoisomerase 3, putative 0.0089 0.0078 0.047
Brugia malayi beta-NAC-like protein 0.0034 0.0013 0.0091
Mycobacterium ulcerans TetR family transcriptional regulator 0.2807 0.3332 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0161 0.0165 0.0811
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0032 0.0289
Brugia malayi Papain family cysteine protease containing protein 0.0026 0.0003 0.0022
Brugia malayi jmjC domain containing protein 0.0056 0.0039 0.0273
Loa Loa (eye worm) hypothetical protein 0.005 0.0032 0.0226
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0035 0.0015 0.0044
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0062 0.0047 0.0375
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0055 0.0038 0.0304
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.005 0.0032 0.0226
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.005 0.0032 0.0032
Leishmania major DNA topoisomerase 1A 0.0089 0.0078 0.0629
Loa Loa (eye worm) endoplasmin 0.0349 0.039 0.272
Loa Loa (eye worm) hypothetical protein 0.009 0.008 0.0559
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0108 0.0102 0.0916
Echinococcus multilocularis sterol regulatory element binding protein 0.0085 0.0074 0.0074
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0017 0.0137
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0017 0.0137
Echinococcus multilocularis casein kinase I alpha 0.0039 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.009 0.008 0.0559
Echinococcus granulosus GPCR family 2 0.0047 0.0028 0.0028
Echinococcus granulosus Niemann Pick C1 protein 0.0284 0.0312 0.0312
Trypanosoma cruzi DNA topoisomerase III, putative 0.0089 0.0078 0.0629
Mycobacterium ulcerans fatty-acid-CoA ligase 0.009 0.008 0.024
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.0312 0.2806
Leishmania major 4-coumarate:coa ligase-like protein 0.0121 0.0117 0.0936
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0066 0.0052 0.0155
Plasmodium vivax heat shock protein, putative 0.0124 0.0121 0.0733
Brugia malayi Carboxylesterase family protein 0.0422 0.0477 0.3328
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0055 0.0038 0.0265
Plasmodium falciparum heat shock protein 90, putative 0.0124 0.0121 0.0733
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0149 0.015 0.045
Schistosoma mansoni nAChR subunit 0.005 0.0032 0.0032
Trypanosoma brucei DNA topoisomerase ii 0.1064 0.1245 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0008 0.0058
Brugia malayi Carboxylesterase family protein 0.0422 0.0477 0.3328
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0032 0.0289
Brugia malayi AMP-binding enzyme family protein 0.0121 0.0117 0.0813
Trichomonas vaginalis heat shock protein, putative 0.0241 0.026 0.2344
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0012 0.011
Echinococcus multilocularis transcription factor btf3 0.0034 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0056 0.0039 0.0273
Loa Loa (eye worm) hypothetical protein 0.0037 0.0016 0.0111
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0064 0.0048 0.0048
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0108 0.0102 0.0586
Loa Loa (eye worm) hypothetical protein 0.003 0.0008 0.0058
Loa Loa (eye worm) hypothetical protein 0.005 0.0032 0.0226
Plasmodium vivax endoplasmin, putative 0.0349 0.039 0.2416
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0161 0.0165 0.0982
Loa Loa (eye worm) hypothetical protein 0.0149 0.015 0.1047
Trypanosoma cruzi heat shock protein 85, putative 0.0241 0.026 0.2091
Schistosoma mansoni jumonji domain containing protein 0.0056 0.0039 0.0039
Leishmania major casein kinase, putative 0.0039 0.0019 0.0152
Echinococcus granulosus casein kinase I delta 0.0039 0.0019 0.0019
Trypanosoma cruzi cysteine peptidase, putative 0.0191 0.0201 0.1612
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0003 0.003
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0008 0.0008
Trypanosoma cruzi casein kinase, putative 0.0039 0.0019 0.0152
Trypanosoma cruzi casein kinase, putative 0.0039 0.0019 0.0152
Brugia malayi TAR-binding protein 0.0062 0.0046 0.0322
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0029 0.0029
Trypanosoma brucei heat shock protein, putative 0.0349 0.039 0.3131
Brugia malayi hypothetical protein 0.0071 0.0058 0.0401
Mycobacterium tuberculosis Probable hydrolase 0.0149 0.015 0.045
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0089 0.0078 0.0439
Leishmania major heat shock protein 83-1 0.0349 0.039 0.3131
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0161 0.0165 0.0495
Echinococcus multilocularis inositol monophosphatase 1 0.0074 0.0061 0.0061
Onchocerca volvulus 0.0039 0.0019 0.0171
Echinococcus multilocularis Niemann Pick C1 protein 0.0284 0.0312 0.0312
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0000098932 0.0000098932
Loa Loa (eye worm) carboxylesterase 0.0422 0.0477 0.3328
Leishmania major hypothetical protein, conserved 0.0056 0.0039 0.0314
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0038 0.0017 0.0017
Brugia malayi PHD-finger family protein 0.0031 0.001 0.0067
Brugia malayi jmjC domain containing protein 0.0056 0.0039 0.0273
Plasmodium falciparum cysteine proteinase falcipain 2a 0.005 0.0032 0.0182
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.0079 0.0554
Loa Loa (eye worm) hypothetical protein 0.009 0.008 0.0559
Plasmodium vivax DNA topoisomerase 3, putative 0.0089 0.0078 0.047
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0046 0.0322
Loa Loa (eye worm) hypothetical protein 0.005 0.0032 0.0226
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0071 0.0058 0.0172
Toxoplasma gondii ABC1 family protein 0.0149 0.015 0.0889
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0008 0.0008
Brugia malayi beta-lactamase family protein 0.0149 0.015 0.1047
Schistosoma mansoni cellular tumor antigen P53 0.03 0.0332 0.0332
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0074 0.0061 0.0602
Brugia malayi Carboxylesterase family protein 0.0071 0.0058 0.0401
Trypanosoma cruzi DNA topoisomerase III, putative 0.0089 0.0078 0.0629
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0079 0.0079
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0161 0.0165 0.0567
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0038 0.0017 0.0017
Plasmodium vivax DNA gyrase subunit B, putative 0.0988 0.1155 0.7195
Loa Loa (eye worm) jmjC domain-containing protein 0.0056 0.0039 0.0273
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0055 0.0038 0.0428
Entamoeba histolytica acyl-CoA synthetase, putative 0.0121 0.0117 0.115
Toxoplasma gondii exonuclease III APE 0.0055 0.0038 0.0186
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0005 0.004
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0046 0.0046
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0035 0.0015 0.0102
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0108 0.0102 0.0263
Mycobacterium ulcerans acetyl-CoA synthetase 0.0035 0.0015 0.0044
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0092 0.0082 0.0656
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0139 0.0138 0.0414
Loa Loa (eye worm) hypothetical protein 0.0077 0.0065 0.0451
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0191 0.0201 0.1612
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.005 0.0032 0.0032
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.005 0.0032 0.0226
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0026 0.0003 0.0024
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0008 0.0008
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0108 0.0102 0.0305
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0008 0.0058
Echinococcus multilocularis lysine specific demethylase 5A 0.021 0.0223 0.0223
Loa Loa (eye worm) hypothetical protein 0.0121 0.0117 0.0813
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0284 0.0312 0.3074
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0008 0.0008
Loa Loa (eye worm) bromodomain containing protein 0.0024 0.0001 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0008 0.0058
Brugia malayi Bromodomain containing protein 0.0044 0.0025 0.0175
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0008 0.0058
Trypanosoma brucei heat shock protein, putative 0.0349 0.039 0.3131
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0008 0.0058
Mycobacterium ulcerans acyl-CoA synthetase 0.0035 0.0015 0.0044
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.005 0.0032 0.0032
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0191 0.0201 0.1612
Plasmodium falciparum casein kinase 1 0.0039 0.0019 0.0099
Loa Loa (eye worm) hypothetical protein 0.0101 0.0093 0.065
Loa Loa (eye worm) hypothetical protein 0.0047 0.0028 0.0195
Echinococcus multilocularis neuroligin 0.0071 0.0058 0.0058
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0108 0.0102 0.0263
Loa Loa (eye worm) LGC-31 protein 0.005 0.0032 0.0226
Entamoeba histolytica hypothetical protein 0.0146 0.0147 0.1447
Giardia lamblia Histone acetyltransferase GCN5 0.0077 0.0065 0.0733
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0055 0.0038 0.0218
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0108 0.0102 0.0407
Mycobacterium ulcerans acyl-CoA synthetase 0.0121 0.0117 0.035
Loa Loa (eye worm) heat shock protein 75 0.0124 0.0121 0.0841
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.009 0.008 0.024
Trichomonas vaginalis esterase, putative 0.0149 0.015 0.1351
Onchocerca volvulus 0.0038 0.0017 0.0156
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0108 0.0102 0.0916
Trypanosoma cruzi heat shock protein 90, putative 0.0349 0.039 0.3131
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0272 0.0298 0.0298
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.1064 0.1245 1
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0038 0.0017 0.0193
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.005 0.0032 0.0226
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0061 0.049
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0000098932 0.0001
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0015 0.0044
Mycobacterium ulcerans hypothetical protein 0.0149 0.015 0.045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0032 0.0289
Schistosoma mansoni hypothetical protein 0.0082 0.0071 0.0071
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0008 0.0008
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0034 0.0276
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0008 0.0058
Echinococcus multilocularis dna polymerase eta 0.0023 0.0000098932 0.0000098932
Onchocerca volvulus 0.0071 0.0058 0.0518
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.005 0.0032 0.0289
Echinococcus multilocularis rho GTPase activating protein 20 0.0089 0.0078 0.0078
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0079 0.0079
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0191 0.0201 0.1612
Brugia malayi Cathepsin L-like precursor 0.005 0.0032 0.0225
Onchocerca volvulus 0.005 0.0032 0.0292
Trichomonas vaginalis endoplasmin, putative 0.0232 0.025 0.2251
Brugia malayi intermediate filament protein 0.0079 0.0066 0.0463
Loa Loa (eye worm) cytochrome P450 family protein 0.0083 0.0072 0.0503
Loa Loa (eye worm) hypothetical protein 0.005 0.0032 0.0226
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0035 0.0015 0.0117
Brugia malayi Cathepsin L-like precursor 0.005 0.0032 0.0225
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.005 0.0032 0.0226
Mycobacterium ulcerans acyl-CoA synthetase 0.0121 0.0117 0.035
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0149 0.015 0.1047
Schistosoma mansoni transcription factor btf3 0.0034 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0061 0.0045 0.0315
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0124 0.0121 0.1188
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0125 0.0122 0.0122
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.0017 0.012
Trypanosoma brucei heat shock protein, putative 0.0349 0.039 0.3131
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.0034 0.0164
Trypanosoma cruzi Heat shock protein 83, putative 0.0349 0.039 0.3131
Chlamydia trachomatis DNA gyrase subunit B 0.0988 0.1155 0.7057
Entamoeba histolytica hypothetical protein 0.0146 0.0147 0.1447
Plasmodium vivax DNA topoisomerase II, putative 0.087 0.1014 0.6311
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0191 0.0201 0.1612
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0082 0.0082
Brugia malayi Protein kinase domain containing protein 0.0092 0.0082 0.0571
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0062 0.0047 0.0241
Brugia malayi PHD-finger family protein 0.003 0.0008 0.0058
Entamoeba histolytica acyl-coA synthetase, putative 0.0121 0.0117 0.115
Mycobacterium tuberculosis Probable oxidoreductase 0.012 0.0116 0.0349
Trypanosoma brucei trypanothione reductase 0.0047 0.0029 0.0232
Trypanosoma cruzi cysteine peptidase, putative 0.005 0.0032 0.0258
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0008 0.0058
Trypanosoma brucei DNA topoisomerase III, putative 0.0089 0.0078 0.0629
Loa Loa (eye worm) hypothetical protein 0.005 0.0032 0.0226
Brugia malayi Cation transporter family protein 0.005 0.0032 0.0226
Loa Loa (eye worm) hypothetical protein 0.003 0.0008 0.0058
Leishmania major hypothetical protein, conserved 0.0149 0.015 0.1205
Loa Loa (eye worm) hypothetical protein 0.003 0.0008 0.0058
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.087 0.1014 0.1014
Brugia malayi AMP-binding enzyme family protein 0.0121 0.0117 0.0813
Echinococcus multilocularis neuropeptide receptor A26 0.0457 0.052 0.052
Trypanosoma brucei developmentally regulated phosphoprotein 0.0108 0.0102 0.0817
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0071 0.0058 0.0058
Onchocerca volvulus 0.0071 0.0058 0.0518
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.005 0.0032 0.0226
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0124 0.0121 0.0121
Schistosoma mansoni hypothetical protein 0.0249 0.027 0.027
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0191 0.0201 0.1612
Mycobacterium tuberculosis Probable two component sensor kinase 0.0108 0.0102 0.0305
Loa Loa (eye worm) beta-lactamase 0.0149 0.015 0.1047
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0064 0.0048 0.0336
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0161 0.0165 0.0165
Brugia malayi cathepsin L-like precursor 0.0034 0.0012 0.0086
Leishmania major heat shock protein 83-1 0.0349 0.039 0.3131
Mycobacterium ulcerans DNA gyrase subunit A 0.1364 0.1605 0.4815
Echinococcus granulosus DNA topoisomerase 2 alpha 0.087 0.1014 0.1014
Plasmodium vivax DNA gyrase subunit A, putative 0.1364 0.1605 1
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0056 0.0039 0.0314
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0087 0.0076 0.0425
Loa Loa (eye worm) hypothetical protein 0.0035 0.0015 0.0102
Entamoeba histolytica cysteine proteinase 2 0.0026 0.0003 0.003
Leishmania major heat shock protein 83-1 0.0349 0.039 0.3131
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0125 0.0122 0.0122
Brugia malayi AMP-binding enzyme family protein 0.0121 0.0117 0.0813
Trichomonas vaginalis D-aminoacylase, putative 0.0149 0.015 0.1351
Plasmodium vivax acetyl-CoA synthetase, putative 0.0035 0.0015 0.0072
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.0312 0.2806
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0108 0.0102 0.0102
Giardia lamblia PHD finger protein 15 0.003 0.0008 0.0093
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0089 0.0078 0.0629
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0249 0.027 0.1885
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0008 0.0075
Brugia malayi hypothetical protein 0.0034 0.0012 0.0086
Brugia malayi Papain family cysteine protease containing protein 0.0026 0.0003 0.0022
Loa Loa (eye worm) hypothetical protein 0.0034 0.0012 0.0086
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0008 0.0058
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.005 0.0032 0.0226
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0149 0.015 0.045
Onchocerca volvulus 0.03 0.0332 0.2988
Loa Loa (eye worm) glutathione reductase 0.0047 0.0029 0.0203
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0062 0.0047 0.0375
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0108 0.0102 0.0305
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0035 0.0015 0.0044
Leishmania major heat shock protein 83-1 0.0349 0.039 0.3131
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0017 0.0154
Schistosoma mansoni acetyl-CoA synthetase 0.0035 0.0015 0.0015
Echinococcus granulosus tumor protein p63 0.2052 0.2429 0.2429
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.005 0.0032 0.0032
Echinococcus multilocularis acetylcholinesterase 0.0422 0.0477 0.0477
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0032 0.0289
Schistosoma mansoni hypothetical protein 0.0082 0.0071 0.0071
Schistosoma mansoni heat shock protein 0.0349 0.039 0.039
Leishmania major protein kinase, putative 0.0062 0.0047 0.0375
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0074 0.0669
Echinococcus multilocularis expressed conserved protein 0.0187 0.0196 0.0196
Trichomonas vaginalis penicillin-binding protein, putative 0.0149 0.015 0.1351
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0149 0.015 0.015
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0035 0.0015 0.0044
Plasmodium falciparum cysteine proteinase falcipain 3 0.005 0.0032 0.0182
Leishmania major heat shock protein 83-1 0.0349 0.039 0.3131
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0925 0.108 0.753
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0008 0.0008
Mycobacterium ulcerans hypothetical protein 0.0121 0.0117 0.035
Brugia malayi cytoplasmic intermediate filament protein 0.0042 0.0023 0.0158
Brugia malayi CHE-14 protein 0.0085 0.0074 0.0519
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0027 0.0005 0.0033
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0422 0.0477 0.0477
Trypanosoma cruzi heat shock protein 90, putative 0.0241 0.026 0.2091
Entamoeba histolytica DNA topoisomerase II, putative 0.087 0.1014 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0032 0.0225
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.005 0.0032 0.0032
Echinococcus granulosus nAChR subunit 0.0027 0.0005 0.0005
Echinococcus multilocularis DNA topoisomerase 3 beta 1 0.0089 0.0078 0.0078
Brugia malayi excitatory GABA receptor EXP-1A 0.005 0.0032 0.0226
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0032 0.0289
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0012 0.011
Toxoplasma gondii thioredoxin reductase 0.0047 0.0029 0.013
Brugia malayi beta-lactamase 0.0149 0.015 0.1047
Onchocerca volvulus Alhambra homolog 0.003 0.0008 0.0075
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0161 0.0165 0.0453
Leishmania major mitochondrial DNA topoisomerase II 0.1064 0.1245 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0121 0.0117 0.035
Loa Loa (eye worm) hypothetical protein 0.0302 0.0334 0.2328
Trypanosoma cruzi casein kinase, putative 0.0039 0.0019 0.0152
Entamoeba histolytica cysteine protease, putative 0.0026 0.0003 0.003
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0121 0.0117 0.035
Schistosoma mansoni protein phosphatase 2C 0.0056 0.0039 0.0039
Leishmania major cathepsin L-like protease 0.005 0.0032 0.0258
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0032 0.0289
Brugia malayi Cathepsin L-like precursor 0.005 0.0032 0.0225
Echinococcus multilocularis Niemann Pick C1 protein 0.0199 0.021 0.021
Loa Loa (eye worm) hypothetical protein 0.0027 0.0005 0.0033
Onchocerca volvulus 0.003 0.0008 0.0075
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0017 0.0137
Brugia malayi jmjC domain containing protein 0.0056 0.0039 0.0273
Echinococcus multilocularis glycine receptor subunit beta 0.005 0.0032 0.0032
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.005 0.0032 0.0032
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.2807 0.3332 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0191 0.0201 0.1612
Plasmodium vivax casein kinase 1, putative 0.0039 0.0019 0.0099
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.005 0.0032 0.0226
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0058 0.0041 0.0041
Echinococcus granulosus BC026374 protein S09 family 0.0071 0.0058 0.0058
Onchocerca volvulus 0.0149 0.015 0.1352
Echinococcus multilocularis nAChR subunit 0.0027 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.005 0.0032 0.0226
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0988 0.1155 0.7133
Echinococcus granulosus peptidase Clp S14 family 0.0106 0.0099 0.0099
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0005 0.0035
Plasmodium falciparum JmjC domain-containing protein, putative 0.0056 0.0039 0.0225
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.0312 0.2806
Echinococcus multilocularis JmjC domain containing protein 4 0.0056 0.0039 0.0039
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.0312 0.2806
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0015 0.0044
Giardia lamblia Heat shock protein HSP 90-alpha 0.0241 0.026 0.2945
Plasmodium falciparum phd finger protein, putative 0.003 0.0008 0.0032
Brugia malayi Bromodomain containing protein 0.008 0.0068 0.0473
Echinococcus granulosus histone lysine methyltransferase setb 0.0136 0.0135 0.0135
Schistosoma mansoni hypothetical protein 0.0082 0.0071 0.0071
Toxoplasma gondii heat shock protein 90, putative 0.0349 0.039 0.2391
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0115 0.011 0.011
Echinococcus multilocularis glycine receptor subunit beta 0.005 0.0032 0.0032
Echinococcus granulosus lysine specific demethylase 5A 0.0212 0.0226 0.0226
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.005 0.0032 0.0032
Schistosoma mansoni aldehyde dehydrogenase 0.0179 0.0187 0.0187
Echinococcus multilocularis cathepsin L cysteine protease 0.005 0.0032 0.0032
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0035 0.0015 0.0117
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.012 0.0116 0.0307
Schistosoma mansoni neuroligin 3 (S09 family) 0.0071 0.0058 0.0058
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.012 0.0116 0.0116
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.012 0.0116 0.0116
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0124 0.0121 0.0121
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0008 0.0058
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0062 0.0047 0.0327
Loa Loa (eye worm) hypothetical protein 0.005 0.0032 0.0226
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0035 0.0015 0.004
Leishmania major heat shock protein 83-1 0.0349 0.039 0.3131
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.005 0.0032 0.0226
Echinococcus granulosus glycine receptor subunit alpha 1 0.005 0.0032 0.0032
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0015 0.0044
Trypanosoma brucei heat shock protein 90, putative 0.0349 0.039 0.3131
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0136 0.0135 0.0135
Echinococcus granulosus lysine specific demethylase 6a 0.0056 0.0039 0.0039
Schistosoma mansoni inositol monophosphatase 0.0074 0.0061 0.0061
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.029 0.0319 0.0319
Giardia lamblia Pms1-like protein 0.0108 0.0102 0.115
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0008 0.0058
Brugia malayi Cathepsin L-like precursor 0.005 0.0032 0.0225
Echinococcus multilocularis cathepsin L cysteine protease 0.005 0.0032 0.0032
Brugia malayi Protein kinase domain containing protein 0.0062 0.0047 0.0327
Plasmodium falciparum basic transcription factor 3b, putative 0.0034 0.0013 0.0062
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0065 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0027 0.0005 0.0033
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0062 0.0047 0.0375
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0071 0.0058 0.0517
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0149 0.015 0.045
Chlamydia trachomatis DNA gyrase subunit B 0.0795 0.0924 0.554
Loa Loa (eye worm) hypothetical protein 0.0119 0.0114 0.0796
Trypanosoma brucei heat shock protein, putative 0.0349 0.039 0.3131
Brugia malayi follicle stimulating hormone receptor 0.0925 0.108 0.753
Loa Loa (eye worm) RNA binding protein 0.0062 0.0046 0.0322
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0035 0.0015 0.0117
Schistosoma mansoni lipoxygenase 0.0118 0.0114 0.0114
Brugia malayi latrophilin 2 splice variant baaae 0.0101 0.0093 0.065
Loa Loa (eye worm) hypothetical protein 0.0149 0.015 0.1047
Trypanosoma cruzi cysteine proteinase, putative 0.0026 0.0003 0.0024
Echinococcus granulosus expressed conserved protein 0.0187 0.0196 0.0196
Trichomonas vaginalis D-aminoacylase, putative 0.0149 0.015 0.1351
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.005 0.0032 0.0032
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0032 0.0289
Schistosoma mansoni patched 1 0.0085 0.0074 0.0074
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0017 0.0017
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0008 0.0008
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0035 0.0015 0.0044
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0003 0.0027
Brugia malayi nuclear hormone receptor 0.003 0.0008 0.0058
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0836 0.0972 0.6782
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.009 0.008 0.0011
Echinococcus granulosus dna polymerase eta 0.0023 0.0000098932 0.0000098932
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0055 0.0038 0.0114
Brugia malayi Cytochrome P450 family protein 0.0083 0.0072 0.0503
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0035 0.0015 0.0072
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0000098932 0.0000098932
Loa Loa (eye worm) hypothetical protein 0.0149 0.015 0.1047
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0035 0.0015 0.0143
Onchocerca volvulus 0.005 0.0032 0.0292
Mycobacterium tuberculosis Probable reductase 0.0108 0.0102 0.0305
Giardia lamblia Fructose-bisphosphate aldolase 0.0284 0.0312 0.3525
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.005 0.0032 0.0032
Echinococcus granulosus heat shock protein 90 0.0241 0.026 0.026
Echinococcus granulosus cysteine protease 0.0026 0.0003 0.0003
Mycobacterium ulcerans two component sensor kinase MprB 0.0108 0.0102 0.0305
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0108 0.0102 0.0916
Leishmania major heat shock protein, putative 0.0124 0.0121 0.0967
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0174 0.0181 0.1452
Onchocerca volvulus Huntingtin homolog 0.0119 0.0114 0.1028
Echinococcus granulosus neuroligin 0.0071 0.0058 0.0058
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.005 0.0032 0.0032
Echinococcus granulosus acetylcholinesterase 0.0422 0.0477 0.0477
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0039 0.0019 0.0132
Mycobacterium tuberculosis Conserved protein 0.0149 0.015 0.045
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0029 0.0087
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0055 0.0038 0.0304
Echinococcus granulosus cathepsin L cysteine proteinase 0.005 0.0032 0.0032
Echinococcus granulosus casein kinase I alpha 0.0039 0.0019 0.0019
Onchocerca volvulus 0.0035 0.0015 0.0132
Schistosoma mansoni DNA topoisomerase II 0.087 0.1014 0.1014
Entamoeba histolytica cysteine protease, putative 0.0026 0.0003 0.003
Mycobacterium ulcerans putative regultory protein 0.0108 0.0102 0.0305
Loa Loa (eye worm) hypothetical protein 0.03 0.0332 0.2314
Onchocerca volvulus 0.005 0.0032 0.0292
Onchocerca volvulus Cathepsin L homolog 0.005 0.0032 0.029
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0032 0.0289
Onchocerca volvulus 0.0027 0.0005 0.0042
Loa Loa (eye worm) hypothetical protein 0.0199 0.021 0.1467
Loa Loa (eye worm) hypothetical protein 0.0071 0.0058 0.0401
Mycobacterium tuberculosis Probable lipase LipE 0.0149 0.015 0.045
Onchocerca volvulus 0.005 0.0032 0.029
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0161 0.0165 0.0495
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0013 0.0104
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0046 0.0322
Echinococcus multilocularis lamin dm0 0.0079 0.0066 0.0066
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.005 0.0032 0.0226
Schistosoma mansoni hypothetical protein 0.0109 0.0102 0.0102
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0108 0.0102 0.0102
Trichomonas vaginalis CK1 family protein kinase 0.0039 0.0019 0.017
Echinococcus multilocularis dual specificity protein kinase clk2 0.0062 0.0047 0.0047
Echinococcus granulosus heat shock protein 90 0.0349 0.039 0.039
Loa Loa (eye worm) hypothetical protein 0.0136 0.0135 0.0945
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0052 0.0034 0.024
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0149 0.015 0.1047
Mycobacterium leprae Probable two component sensor kinase MprB 0.0108 0.0102 0.0263
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.0079 0.0554
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0008 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0008 0.0058
Loa Loa (eye worm) hypothetical protein 0.0108 0.0102 0.071
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0032 0.0289
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0008 0.0008
Trypanosoma cruzi hypothetical protein, conserved 0.0149 0.015 0.1205
Leishmania major cysteine peptidase A (CPA) 0.005 0.0032 0.0258
Echinococcus multilocularis cathepsin l cysteine peptidase 0.005 0.0032 0.0032
Brugia malayi jmjC domain containing protein 0.0056 0.0039 0.0273
Schistosoma mansoni coup transcription factor 0.003 0.0008 0.0008
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0161 0.0165 0.0811
Loa Loa (eye worm) ACC-1 protein 0.005 0.0032 0.0226
Mycobacterium ulcerans acyl-CoA synthetase 0.0035 0.0015 0.0044
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0035 0.0015 0.0015
Echinococcus granulosus casein kinase I alpha 0.0039 0.0019 0.0019
Brugia malayi hypothetical protein 0.1221 0.1434 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0079 0.0066 0.0463
Brugia malayi Thioredoxin reductase 0.0047 0.0029 0.0203
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.005 0.0032 0.0032
Onchocerca volvulus 0.005 0.0032 0.0292
Leishmania major heat shock protein 83-1 0.0349 0.039 0.3131
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0074 0.0061 0.0148
Schistosoma mansoni jumonji/arid domain-containing protein 0.0212 0.0226 0.0226
Schistosoma mansoni jumonji/arid domain-containing protein 0.0212 0.0226 0.0226
Entamoeba histolytica hypothetical protein 0.0027 0.0005 0.0045
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0031 0.0009 0.0026
Echinococcus granulosus glycine receptor subunit beta 0.005 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0077 0.0065 0.0452
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0161 0.0165 0.0165
Plasmodium falciparum heat shock protein 90, putative 0.0124 0.0121 0.0733
Loa Loa (eye worm) hypothetical protein 0.0037 0.0016 0.0111
Mycobacterium tuberculosis Probable lipase LipD 0.0149 0.015 0.045
Plasmodium falciparum DNA topoisomerase 2 0.087 0.1014 0.6311
Brugia malayi Cathepsin L-like precursor 0.005 0.0032 0.0225
Brugia malayi Cathepsin L-like precursor 0.005 0.0032 0.0225
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0039 0.0019 0.0152
Loa Loa (eye worm) hypothetical protein 0.0077 0.0065 0.0452
Echinococcus granulosus dual specificity protein kinase clk2 0.0062 0.0047 0.0047
Mycobacterium ulcerans beta-lactamase 0.0149 0.015 0.045
Loa Loa (eye worm) DNA topoisomerase III beta-1 0.0089 0.0078 0.0547
Mycobacterium ulcerans DNA topoisomerase I 0.0089 0.0078 0.0235
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0079 0.0079
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0106 0.0099 0.0296
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0022 0.0022
Echinococcus granulosus histone acetyltransferase KAT2B 0.0087 0.0076 0.0076
Leishmania major heat shock protein 83-1 0.0349 0.039 0.3131
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0032 0.0289
Plasmodium falciparum heat shock protein 90 0.0349 0.039 0.2416
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0008 0.0008
Leishmania major acetyl-CoA synthetase, putative 0.0035 0.0015 0.0117
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0149 0.015 0.045
Onchocerca volvulus 0.005 0.0032 0.029
Mycobacterium tuberculosis Possible penicillin-binding protein 0.095 0.1109 0.3328
Loa Loa (eye worm) jmjC domain-containing protein 0.0056 0.0039 0.0273
Trypanosoma cruzi hypothetical protein, conserved 0.0149 0.015 0.1205
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0074 0.0061 0.0549
Loa Loa (eye worm) hypothetical protein 0.009 0.008 0.0559
Loa Loa (eye worm) hypothetical protein 0.0027 0.0005 0.0033
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0035 0.0015 0.0044
Echinococcus multilocularis jumonji domain containing 1A 0.0056 0.0039 0.0039
Echinococcus multilocularis muscleblind protein 1 0.0302 0.0334 0.0334
Entamoeba histolytica hypothetical protein 0.0092 0.0082 0.0806
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.005 0.0032 0.0226
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0146 0.0147 0.0147
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0013 0.0117
Entamoeba histolytica transcription factor BTF3, putative 0.0034 0.0013 0.0128
Trypanosoma cruzi heat shock protein 90, putative 0.0225 0.0242 0.194
Leishmania major heat shock protein 83-1 0.0349 0.039 0.3131
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0047 0.0047
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0032 0.0289
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0008 0.0008
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0139 0.0138 0.0372
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0108 0.0102 0.0305
Loa Loa (eye worm) ICD-1 protein 0.0034 0.0013 0.0091
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0027 0.0005 0.0033
Echinococcus granulosus neuropeptide s receptor 0.0457 0.052 0.052
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0017 0.0137
Echinococcus granulosus inositol monophosphatase 1 0.0074 0.0061 0.0061
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0008 0.0008
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0032 0.0289
Leishmania major protein kinase, putative 0.0062 0.0047 0.0375
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0064 0.0048 0.0048
Echinococcus granulosus casein kinase I delta 0.0039 0.0019 0.0019
Plasmodium falciparum endoplasmin, putative 0.0232 0.025 0.1542
Loa Loa (eye worm) hypothetical protein 0.003 0.0008 0.0058
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0241 0.026 0.026
Trypanosoma brucei Heat shock protein 83, putative 0.0349 0.039 0.3131
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0108 0.0102 0.0305
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0064 0.0048 0.0144
Toxoplasma gondii Hsp90 domain-containing protein 0.0124 0.0121 0.0703
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0028 0.0197
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0149 0.015 0.015
Brugia malayi jmjC domain containing protein 0.0272 0.0298 0.2078
Brugia malayi Inositol-1 0.0074 0.0061 0.0426
Mycobacterium leprae Probable DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) ( 0.0089 0.0078 0.0192
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0035 0.0015 0.0117
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0062 0.0047 0.0375
Trypanosoma cruzi DNA topoisomerase II, putative 0.0781 0.0908 0.7287
Brugia malayi Endoplasmin precursor 0.0349 0.039 0.272
Loa Loa (eye worm) hypothetical protein 0.0027 0.0005 0.0033
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0027 0.0005 0.0005
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0058 0.0041 0.0041
Echinococcus granulosus peregrin 0.0039 0.0019 0.0019
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.005 0.0032 0.0289
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0008 0.0058
Loa Loa (eye worm) inositol-1 0.0074 0.0061 0.0426
Giardia lamblia Heat shock protein HSP 90-alpha 0.0349 0.039 0.441
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0008 0.0008
Mycobacterium leprae Probable two-component sensor kinase 0.0108 0.0102 0.0263
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0089 0.0078 0.0629
Trypanosoma brucei heat shock protein, putative 0.0349 0.039 0.3131
Loa Loa (eye worm) hypothetical protein 0.0047 0.0028 0.0197
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0046 0.0046
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0064 0.0048 0.0048
Plasmodium falciparum protein serine/threonine kinase-1 0.0062 0.0047 0.0273
Entamoeba histolytica DNA topoisomerase III, putative 0.0089 0.0078 0.0773
Brugia malayi Cation transporter family protein 0.005 0.0032 0.0226
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.005 0.0032 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0017 0.0154
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0056 0.0039 0.0194
Schistosoma mansoni ap endonuclease 0.0055 0.0038 0.0038
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0108 0.0102 0.0305
Loa Loa (eye worm) hypothetical protein 0.0038 0.0017 0.012
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0092 0.0082 0.0656
Loa Loa (eye worm) hypothetical protein 0.0105 0.0097 0.0679
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0032 0.0289
Loa Loa (eye worm) cysteine protease 0.005 0.0032 0.0225
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0035 0.0015 0.0102
Mycobacterium ulcerans aldehyde dehydrogenase 0.0179 0.0187 0.0559
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0061 0.049
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.0048 0.0144
Loa Loa (eye worm) oxidoreductase 0.0035 0.0015 0.0102
Loa Loa (eye worm) hypothetical protein 0.1221 0.1434 1
Schistosoma mansoni pyruvate dehydrogenase 0.0108 0.0102 0.0102
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0241 0.026 0.0741
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0017 0.0154
Mycobacterium ulcerans carboxylesterase, LipT 0.0071 0.0058 0.0172
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0055 0.0039 0.0072
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0062 0.0047 0.0375
Plasmodium vivax SET domain protein, putative 0.012 0.0116 0.0703
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0015 0.0044
Loa Loa (eye worm) hypothetical protein 0.0071 0.0058 0.0401
Entamoeba histolytica cysteine protease, putative 0.0026 0.0003 0.003
Onchocerca volvulus 0.0249 0.027 0.2434
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0241 0.026 0.142
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0008 0.0075
Plasmodium vivax glutathione reductase, putative 0.0047 0.0029 0.0162
Echinococcus granulosus intermediate filament protein 0.0079 0.0066 0.0066
Entamoeba histolytica cysteine proteinase, putative 0.005 0.0032 0.0317
Echinococcus granulosus survival motor neuron protein 1 0.1221 0.1434 0.1434
Entamoeba histolytica acyl-CoA synthetase, putative 0.0121 0.0117 0.115
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0108 0.0102 0.0305
Loa Loa (eye worm) hypothetical protein 0.005 0.0032 0.0226
Mycobacterium ulcerans acyl-CoA synthetase 0.0035 0.0015 0.0044
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0008 0.0008
Echinococcus multilocularis cysteine protease 0.005 0.0032 0.0032
Treponema pallidum heat shock protein 90 0.0241 0.026 0.142
Brugia malayi hypothetical protein 0.0119 0.0114 0.0796
Trypanosoma brucei heat shock protein, putative 0.0349 0.039 0.3131
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0089 0.0078 0.0078
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0071 0.0058 0.0172
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0032 0.0289
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0199 0.021 0.2074
Loa Loa (eye worm) hypothetical protein 0.0079 0.0066 0.0463
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0087 0.0076 0.0456
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0039 0.0019 0.0132
Leishmania major heat shock protein 83-1 0.0349 0.039 0.3131
Loa Loa (eye worm) hypothetical protein 0.009 0.008 0.0559
Loa Loa (eye worm) carboxylesterase 0.0071 0.0058 0.0401
Echinococcus multilocularis 0.0061 0.0045 0.0045
Plasmodium falciparum histone acetyltransferase GCN5 0.0077 0.0065 0.0386
Trichomonas vaginalis heat shock protein, putative 0.0232 0.025 0.2251
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0013 0.0117
Entamoeba histolytica acetyltransferase, GNAT family 0.0077 0.0065 0.0639
Loa Loa (eye worm) hypothetical protein 0.009 0.008 0.0559
Echinococcus multilocularis casein kinase I alpha 0.0039 0.0019 0.0019
Brugia malayi Hsp90 protein 0.0124 0.0121 0.0841
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0008 0.0058
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0071 0.0058 0.0058
Trichomonas vaginalis heat shock protein, putative 0.0241 0.026 0.2344
Schistosoma mansoni nAChR subunit 0.005 0.0032 0.0032
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0017 0.0017
Leishmania major cathepsin L-like protease 0.005 0.0032 0.0258
Mycobacterium leprae Probable lipase LipE 0.0149 0.015 0.0409
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0032 0.0289
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0032 0.0289
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.005 0.0032 0.0226
Loa Loa (eye worm) hypothetical protein 0.0071 0.0058 0.0401
Echinococcus granulosus DNA topoisomerase 3 alpha 0.0089 0.0078 0.0078
Trypanosoma cruzi major cysteine proteinase, putative 0.015 0.0152 0.1219
Loa Loa (eye worm) hypothetical protein 0.0149 0.015 0.1047
Brugia malayi AMP-binding enzyme family protein 0.0035 0.0015 0.0102
Onchocerca volvulus 0.005 0.0032 0.029
Entamoeba histolytica casein kinase 1, putative 0.0039 0.0019 0.0186
Schistosoma mansoni lamin 0.0079 0.0066 0.0066
Onchocerca volvulus 0.0034 0.0012 0.0111
Onchocerca volvulus Huntingtin homolog 0.0119 0.0114 0.1028
Echinococcus granulosus phd:f box containing protein 0.0056 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0071 0.0058 0.0401
Trypanosoma cruzi cysteine peptidase, putative 0.0191 0.0201 0.1612
Echinococcus granulosus zinc finger protein 0.0026 0.0003 0.0003
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.005 0.0032 0.0032
Schistosoma mansoni hypothetical protein 0.0047 0.0028 0.0028
Plasmodium vivax serine/threonine kinase-1, putative 0.0062 0.0047 0.0273
Loa Loa (eye worm) hypothetical protein 0.0422 0.0477 0.3328
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0108 0.0102 0.0586
Giardia lamblia DNA topoisomerase III 0.0089 0.0078 0.0886
Loa Loa (eye worm) hypothetical protein 0.003 0.0008 0.0058
Trypanosoma brucei casein kinase I, isoform 2 0.0039 0.0019 0.0152
Echinococcus granulosus cathepsin l1 0.0034 0.0012 0.0012
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0035 0.0015 0.004
Loa Loa (eye worm) hypothetical protein 0.005 0.0032 0.0226
Loa Loa (eye worm) hypothetical protein 0.0071 0.0058 0.0401
Wolbachia endosymbiont of Brugia malayi DNA gyrase subunit A 0.1364 0.1605 1
Trypanosoma cruzi cysteine protease, putative 0.0026 0.0003 0.0024
Toxoplasma gondii casein kinase I 0.0039 0.0019 0.0067
Loa Loa (eye worm) hypothetical protein 0.0027 0.0005 0.0033
Brugia malayi Cation transporter family protein 0.005 0.0032 0.0226
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.0312 0.2806
Brugia malayi DNA topoisomerase III 0.0089 0.0078 0.0547
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0008 0.0058
Loa Loa (eye worm) hypothetical protein 0.005 0.0032 0.0226
Echinococcus granulosus ubiquitin specific protease 41 0.0038 0.0017 0.0017
Echinococcus granulosus cathepsin l1 0.005 0.0032 0.0032
Trypanosoma cruzi DNA topoisomerase II, putative 0.0781 0.0908 0.7287
Brugia malayi Muscleblind-like protein 0.0302 0.0334 0.2328
Brugia malayi AMP-binding enzyme family protein 0.0035 0.0015 0.0102
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0731 0.0847 0.7624
Onchocerca volvulus 0.0149 0.015 0.1352
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0003 0.003
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.005 0.0032 0.0032
Loa Loa (eye worm) ctsf protein 0.005 0.0032 0.0225
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0121 0.0117 0.035
Toxoplasma gondii cathepsin CPL 0.005 0.0032 0.015
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0108 0.0102 0.0305
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.005 0.0032 0.0032
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.1364 0.1605 0.4815
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0008 0.0058
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0012 0.0121
Loa Loa (eye worm) acetylcholinesterase 1 0.0422 0.0477 0.3328
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0149 0.015 0.1047
Plasmodium vivax heat shock protein 86, putative 0.0349 0.039 0.2416
Loa Loa (eye worm) hypothetical protein 0.0148 0.0149 0.1041
Echinococcus granulosus jumonji domain containing 1A 0.0056 0.0039 0.0039
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0035 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0422 0.0477 0.3328
Toxoplasma gondii DNA topoisomerase 2, putative 0.087 0.1014 0.6299
Echinococcus multilocularis carboxylesterase 5A 0.0422 0.0477 0.0477
Brugia malayi steroid hormone receptor 0.003 0.0008 0.0058
Echinococcus multilocularis muscleblind protein 0.0302 0.0334 0.0334
Brugia malayi Cytochrome P450 family protein 0.0027 0.0005 0.0035
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0272 0.0298 0.0298
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0008 0.0058
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.0034 0.0276
Loa Loa (eye worm) GABA receptor subunit 0.0027 0.0005 0.0033
Loa Loa (eye worm) hypothetical protein 0.005 0.0032 0.0226
Onchocerca volvulus 0.0089 0.0078 0.0706
Treponema pallidum fructose-bisphosphate aldolase 0.0284 0.0312 0.1748
Echinococcus multilocularis casein kinase I delta 0.0039 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0149 0.015 0.1047
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0241 0.026 0.0781
Trypanosoma cruzi cruzipain precursor, putative 0.0191 0.0201 0.1612
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0038 0.0018 0.0018
Trichomonas vaginalis spcc417.12 protein, putative 0.0071 0.0058 0.0517
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0008 0.0008
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.005 0.0032 0.0032
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0042 0.0023 0.0158
Trypanosoma cruzi heat shock protein 85, putative 0.0349 0.039 0.3131
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0148 0.0149 0.1041
Leishmania major cathepsin L-like protease 0.005 0.0032 0.0258
Echinococcus granulosus tar DNA binding protein 0.0062 0.0046 0.0046
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0055 0.0038 0.0304
Echinococcus granulosus transcription factor btf3 0.0034 0.0013 0.0013
Schistosoma mansoni zinc finger protein 0.0026 0.0003 0.0003
Entamoeba histolytica cysteine protease, putative 0.0026 0.0003 0.003
Schistosoma mansoni lamin 0.0079 0.0066 0.0066
Echinococcus multilocularis phd:f box containing protein 0.0056 0.0039 0.0039
Echinococcus multilocularis para nitrobenzyl esterase 0.0071 0.0058 0.0058
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0055 0.0039 0.0004
Loa Loa (eye worm) jmjC domain-containing protein 0.0212 0.0226 0.1574
Loa Loa (eye worm) hypothetical protein 0.005 0.0032 0.0226
Treponema pallidum DNA gyrase, subunit A (gyrA) 0.1364 0.1605 1
Echinococcus granulosus neuropeptide receptor A26 0.0457 0.052 0.052
Schistosoma mansoni nAChR subunit 0.005 0.0032 0.0032
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0046 0.0046
Mycobacterium ulcerans acyl-CoA synthetase 0.0035 0.0015 0.0044
Plasmodium falciparum DNA gyrase subunit B 0.0988 0.1155 0.7195
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0027 0.0005 0.0033
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0035 0.0015 0.0044
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0003 0.0027
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0005 0.004
Echinococcus granulosus cathepsin l cysteine peptidase 0.005 0.0032 0.0032
Echinococcus granulosus glycine receptor subunit alpha 1 0.005 0.0032 0.0032
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0118 0.0114 0.0114
Echinococcus multilocularis nAChR subunit 0.005 0.0032 0.0032
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0085 0.0074 0.0222
Brugia malayi Pre-SET motif family protein 0.0836 0.0972 0.6782
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0055 0.0039 0.0222
Entamoeba histolytica cysteine protease, putative 0.0026 0.0003 0.003
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0071 0.0058 0.0058
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0108 0.0102 0.0305
Loa Loa (eye worm) hypothetical protein 0.0034 0.0012 0.0086
Loa Loa (eye worm) hypothetical protein 0.0085 0.0074 0.0519
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0008 0.0008
Mycobacterium ulcerans heat shock protein 90 0.0241 0.026 0.0781
Onchocerca volvulus 0.0035 0.0015 0.0132
Echinococcus granulosus muscleblind protein 0.0302 0.0334 0.0334
Echinococcus granulosus hypothetical protein 0.0061 0.0045 0.0045
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0008 0.0008
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0027 0.0005 0.0015
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0108 0.0102 0.0305
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0026 0.0003 0.0003
Entamoeba histolytica cysteine protease, putative 0.0026 0.0003 0.003
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.038 0.0427 0.298
Entamoeba histolytica casein kinase, putative 0.0039 0.0019 0.0186
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0029 0.0232
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0047 0.0326
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0017 0.0017
Mycobacterium ulcerans AcrR family transcriptional regulator 0.2807 0.3332 1
Echinococcus multilocularis protein patched 0.0085 0.0074 0.0074
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0035 0.0015 0.0044
Plasmodium vivax vivapain-2 0.005 0.0032 0.0182
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.2807 0.3332 1
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0108 0.0102 0.0916
Trichomonas vaginalis set domain proteins, putative 0.0951 0.1111 1
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0056 0.0039 0.0314
Echinococcus multilocularis dual specificity 0.0092 0.0082 0.0082
Echinococcus granulosus glycine receptor subunit alpha 1 0.005 0.0032 0.0032
Schistosoma mansoni bromodomain containing protein 0.0068 0.0054 0.0054
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0108 0.0102 0.0305
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0781 0.0908 0.7287
Brugia malayi heat shock protein 90 0.0349 0.039 0.272
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0124 0.0121 0.1085
Brugia malayi Carboxylesterase family protein 0.0071 0.0058 0.0401
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0012 0.0012
Giardia lamblia DNA topoisomerase II 0.0762 0.0884 1
Leishmania major heat shock protein 83-1 0.0349 0.039 0.3131
Echinococcus multilocularis geminin 0.0502 0.0573 0.0573
Echinococcus multilocularis survival motor neuron protein 1 0.1221 0.1434 0.1434
Onchocerca volvulus 0.005 0.0032 0.0292
Mycobacterium leprae conserved hypothetical protein 0.0149 0.015 0.0409
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0064 0.0048 0.0387
Schistosoma mansoni hypothetical protein 0.0082 0.0071 0.0071
Trypanosoma cruzi cysteine proteinase, putative 0.0026 0.0003 0.0024
Trichomonas vaginalis heat shock protein, putative 0.0124 0.0121 0.1084
Schistosoma mansoni neurotransmitter gated ion channel 0.0027 0.0005 0.0005
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0026 0.0003 0.0003
Trypanosoma brucei heat shock protein 84, putative 0.0124 0.0121 0.0967
Entamoeba histolytica cysteine protease, putative 0.0026 0.0003 0.003
Leishmania major DNA topoisomerase III, putative 0.0089 0.0078 0.0629
Plasmodium vivax hypothetical protein, conserved 0.0108 0.0102 0.0616
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0000098932 0.0000098932
Echinococcus multilocularis glycine receptor subunit alpha 1 0.005 0.0032 0.0032
Schistosoma mansoni DNA polymerase eta 0.0023 0.0000098932 0.0000098932
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0027 0.0005 0.0033
Wolbachia endosymbiont of Brugia malayi topoisomerase IA, TopA 0.0089 0.0078 0.0258
Loa Loa (eye worm) hypothetical protein 0.005 0.0032 0.0226
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0089 0.0078 0.0705
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0056 0.0039 0.0039
Schistosoma mansoni phosphatidylserine receptor 0.0056 0.0039 0.0039
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0087 0.0076 0.0425
Giardia lamblia Kinase, CK1 Casein kinase 0.0039 0.0019 0.0213
Brugia malayi DNA topoisomerase III beta-1 0.0089 0.0078 0.0547
Leishmania major DNA topoisomerase III, putative 0.0089 0.0078 0.0629
Echinococcus granulosus glycine receptor subunit beta 0.005 0.0032 0.0032
Onchocerca volvulus 0.0047 0.0028 0.0253
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0027 0.0005 0.0005
Plasmodium vivax hypothetical protein, conserved 0.0149 0.015 0.0918
Entamoeba histolytica cysteine proteinase, putative 0.005 0.0032 0.0317
Plasmodium vivax hypothetical protein, conserved 0.003 0.0008 0.0032
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.012 0.0116 0.0673
Leishmania major acetyl-CoA synthetase, putative 0.0035 0.0015 0.0117
Trypanosoma brucei hypothetical protein, conserved 0.0149 0.015 0.1205
Mycobacterium ulcerans acyl-CoA synthetase 0.0121 0.0117 0.035
Schistosoma mansoni ap endonuclease 0.0055 0.0038 0.0038
Onchocerca volvulus 0.0071 0.0058 0.0518
Entamoeba histolytica hypothetical protein 0.0034 0.0013 0.0128
Loa Loa (eye worm) ACC-1 protein 0.005 0.0032 0.0226
Loa Loa (eye worm) hypothetical protein 0.038 0.0427 0.298
Trypanosoma brucei heat shock protein 90, putative 0.0349 0.039 0.3131
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0108 0.0102 0.0305
Trichomonas vaginalis bromodomain-containing protein, putative 0.0087 0.0076 0.0684
Loa Loa (eye worm) papain family cysteine protease containing protein 0.005 0.0032 0.0225
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0074 0.0061 0.0183
Brugia malayi Carboxylesterase family protein 0.0071 0.0058 0.0401
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0032 0.0289
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0008 0.0058
Loa Loa (eye worm) hypothetical protein 0.0035 0.0015 0.0102
Schistosoma mansoni hypothetical protein 0.0502 0.0573 0.0573
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.012 0.0116 0.0349
Brugia malayi Cathepsin L-like precursor 0.0034 0.0012 0.0086
Echinococcus multilocularis musashi 0.0079 0.0066 0.0066
Onchocerca volvulus 0.0079 0.0066 0.0598
Loa Loa (eye worm) fibroinase 0.005 0.0032 0.0225
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0035 0.0015 0.0044
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.005 0.0032 0.0226
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0161 0.0165 0.1011
Loa Loa (eye worm) hypothetical protein 0.0071 0.0058 0.0401
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0008 0.0058
Echinococcus multilocularis microtubule associated protein 2 0.8376 1 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0074 0.0061 0.0549
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0003 0.003
Echinococcus multilocularis protein dispatched 1 0.0097 0.0089 0.0089
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0108 0.0102 0.0305
Schistosoma mansoni hypothetical protein 0.0047 0.0028 0.0028
Trypanosoma cruzi cysteine peptidase, putative 0.0026 0.0003 0.0024
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0028 0.0028
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0038 0.0017 0.0168
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0019 0.0019
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0034 0.0196
Toxoplasma gondii DNA gyrase/topoisomerase IV, A subunit domain-containing protein 0.1364 0.1605 1
Leishmania major cathepsin L-like protease 0.0191 0.0201 0.1612
Trypanosoma cruzi DNA topoisomerase III, putative 0.0089 0.0078 0.0629
Loa Loa (eye worm) hypothetical protein 0.0098 0.0089 0.0624
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.005 0.0032 0.0226
Echinococcus multilocularis glycine receptor subunit alpha 1 0.005 0.0032 0.0032
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0000098932 0.0001
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0000098932 0.0001
Schistosoma mansoni peptidase Clp (S14 family) 0.0161 0.0165 0.0165
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0108 0.0102 0.0305
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0079 0.0079
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0055 0.0038 0.0218
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0035 0.0015 0.0102
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0026 0.0003 0.0003
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0013 0.0104
Schistosoma mansoni nAChR subunit 0.005 0.0032 0.0032
Onchocerca volvulus 0.005 0.0032 0.029
Schistosoma mansoni hypothetical protein 0.0047 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0048 0.003 0.021
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.005 0.0032 0.0226
Schistosoma mansoni heat shock protein 0.0349 0.039 0.039
Schistosoma mansoni transcription factor LCR-F1 0.0146 0.0147 0.0147
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0061 0.049
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0056 0.0039 0.0314
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0032 0.0289
Schistosoma mansoni aldehyde dehydrogenase 0.0179 0.0187 0.0187
Loa Loa (eye worm) hypothetical protein 0.005 0.0032 0.0226
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0121 0.0117 0.035
Trypanosoma cruzi heat shock protein 85, putative 0.0349 0.039 0.3131
Loa Loa (eye worm) hypothetical protein 0.005 0.0032 0.0226
Echinococcus granulosus cathepsin L cysteine protease 0.0026 0.0003 0.0003
Brugia malayi DNA topoisomerase II, alpha isozyme 0.087 0.1014 0.7071
Echinococcus multilocularis neuropeptide s receptor 0.0457 0.052 0.052
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0035 0.0015 0.0044
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0662 0.0765 0.4741
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0055 0.0038 0.0038
Brugia malayi hypothetical protein 0.0052 0.0034 0.024
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0161 0.0165 0.1011
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0202 0.0214 0.0214
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0032 0.0289
Loa Loa (eye worm) hypothetical protein 0.0071 0.0058 0.0401
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0028 0.0197
Chlamydia trachomatis DNA gyrase subunit A 0.1364 0.1605 1
Echinococcus granulosus carboxylesterase 5A 0.0422 0.0477 0.0477
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.0312 0.2806
Entamoeba histolytica cysteine protease, putative 0.0026 0.0003 0.003
Brugia malayi casein kinase I 0.0039 0.0019 0.0132
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.087 0.1014 0.7071
Echinococcus granulosus Niemann Pick C1 protein 0.0199 0.021 0.021
Loa Loa (eye worm) hypothetical protein 0.003 0.0008 0.0058
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0092 0.0082 0.0571
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0241 0.026 0.2091
Echinococcus granulosus heat shock protein 0.0349 0.039 0.039
Trypanosoma cruzi casein kinase, putative 0.0039 0.0019 0.0152
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0139 0.0138 0.0414
Leishmania major cytochrome p450-like protein 0.0027 0.0005 0.004
Echinococcus multilocularis lysine specific demethylase 6a 0.0056 0.0039 0.0039
Onchocerca volvulus 0.012 0.0116 0.1041
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0003 0.0024
Echinococcus multilocularis casein kinase I alpha 0.0039 0.0019 0.0019
Schistosoma mansoni microtubule-associated protein tau 0.8376 1 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0034 0.0276
Schistosoma mansoni hypothetical protein 0.0101 0.0093 0.0093
Brugia malayi Cathepsin L-like precursor 0.0034 0.0012 0.0086
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0108 0.0102 0.0305
Onchocerca volvulus 0.0071 0.0058 0.0518
Leishmania major 4-coumarate:coa ligase-like protein 0.0121 0.0117 0.0936
Trichomonas vaginalis inositol monophosphatase, putative 0.0074 0.0061 0.0549
Trypanosoma cruzi heat shock protein 85, putative 0.0349 0.039 0.3131
Schistosoma mansoni intermediate filament proteins 0.0079 0.0066 0.0066
Echinococcus multilocularis casein kinase I delta 0.0039 0.0019 0.0019
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0092 0.0082 0.0656
Echinococcus multilocularis GPCR, family 2 0.0047 0.0028 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0013 0.0117
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0038 0.0017 0.0138
Leishmania major cathepsin L-like protease 0.0191 0.0201 0.1612
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.005 0.0032 0.0032
Mycobacterium tuberculosis Conserved protein 0.0149 0.015 0.045
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0108 0.0102 0.0305
Brugia malayi Bromodomain containing protein 0.0039 0.0019 0.0136
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.0048 0.0144
Trypanosoma brucei heat shock protein, putative 0.0349 0.039 0.3131
Echinococcus granulosus Protein patched homolog 1 0.0085 0.0074 0.0074
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0035 0.0015 0.0044
Mycobacterium tuberculosis Conserved protein 0.0149 0.015 0.045
Toxoplasma gondii aldehyde dehydrogenase 0.0179 0.0187 0.1116
Toxoplasma gondii NAC domain-containing protein 0.0034 0.0013 0.003
Entamoeba histolytica protein kinase, putative 0.0092 0.0082 0.0806
Giardia lamblia Grp94/Hsp90 0.0241 0.026 0.2945
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0014 0.0014
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0008 0.0008
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0055 0.0038 0.0114
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0028 0.0197
Schistosoma mansoni thyroid hormone receptor 0.0155 0.0158 0.0158
Entamoeba histolytica DNA topoisomerase III, putative 0.0089 0.0078 0.0773
Schistosoma mansoni BC026374 protein (S09 family) 0.0071 0.0058 0.0058
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0988 0.1155 0.3467
Leishmania major cathepsin L-like protease 0.005 0.0032 0.0258
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0008 0.0058
Loa Loa (eye worm) hypothetical protein 0.0037 0.0017 0.0117
Leishmania major basic transcription factor 3a, putative 0.0034 0.0013 0.0104
Loa Loa (eye worm) hypothetical protein 0.009 0.008 0.0559
Leishmania major developmentally regulated phosphoprotein-like protein 0.0108 0.0102 0.0817
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0047 0.0047
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0003 0.003
Echinococcus granulosus casein kinase i 0.0039 0.0019 0.0019
Schistosoma mansoni thyroid hormone receptor 0.0155 0.0158 0.0158
Schistosoma mansoni jumonji domain containing protein 0.0252 0.0274 0.0274
Schistosoma mansoni hypothetical protein 0.0125 0.0122 0.0122
Echinococcus granulosus sterol regulatory element binding protein 0.0085 0.0074 0.0074
Entamoeba histolytica hypothetical protein 0.0146 0.0147 0.1447
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0108 0.0102 0.0817
Onchocerca volvulus 0.0027 0.0005 0.0042
Mycobacterium ulcerans lipase LipD 0.0149 0.015 0.045
Brugia malayi Intermediate filament tail domain containing protein 0.0079 0.0066 0.0463
Loa Loa (eye worm) carboxylesterase 0.0071 0.0058 0.0401
Toxoplasma gondii propionate-CoA ligase 0.0035 0.0015 0.004
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0035 0.0242
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.005 0.0032 0.0226
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0035 0.0015 0.0044
Schistosoma mansoni phd/f-box containing protein 0.0056 0.0039 0.0039
Onchocerca volvulus 0.0149 0.015 0.1352
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0071 0.0058 0.0058
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0065 0.005 0.005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0032 0.0289
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0008 0.0058
Leishmania major hypothetical protein, conserved 0.0108 0.0102 0.0817
Brugia malayi Carboxylesterase family protein 0.0071 0.0058 0.0401
Brugia malayi AMP-binding enzyme family protein 0.0035 0.0015 0.0102
Leishmania major heat shock protein 83-1 0.0349 0.039 0.3131
Trichomonas vaginalis heat shock protein, putative 0.0241 0.026 0.2344
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.005 0.0032 0.0226
Mycobacterium tuberculosis Carboxylesterase LipT 0.0071 0.0058 0.0172
Brugia malayi RNA binding protein 0.0062 0.0046 0.0322
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0108 0.0102 0.0305
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0028 0.0028
Entamoeba histolytica cysteine protease, putative 0.0026 0.0003 0.003
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0108 0.0102 0.0817
Brugia malayi casein kinase 1, delta 0.0039 0.0019 0.0132
Loa Loa (eye worm) hypothetical protein 0.003 0.0008 0.0058
Echinococcus granulosus beta LACTamase domain containing family member 0.0149 0.015 0.015
Loa Loa (eye worm) DNA topoisomerase III 0.0089 0.0078 0.0547
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.0312 0.2806
Loa Loa (eye worm) intermediate filament protein 0.0079 0.0066 0.0463
Brugia malayi Cathepsin L-like cysteine proteinase 0.0034 0.0012 0.0086
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.005 0.0032 0.0226
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0988 0.1155 0.7133
Loa Loa (eye worm) hypothetical protein 0.0034 0.0012 0.0086
Echinococcus granulosus acetylcholinesterase 0.0422 0.0477 0.0477
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0008 0.0008
Toxoplasma gondii hypothetical protein 0.0055 0.0039 0.019
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0029 0.0203
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0106 0.0099 0.0296
Onchocerca volvulus 0.0951 0.1111 1
Schistosoma mansoni endoplasmin 0.0349 0.039 0.039
Trichomonas vaginalis antibiotic synthetase, putative 0.0035 0.0015 0.0131
Mycobacterium ulcerans acyl-CoA synthetase 0.0035 0.0015 0.0044
Leishmania major cathepsin L-like protease 0.005 0.0032 0.0258
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0085 0.0074 0.0222
Leishmania major heat shock protein 83-1 0.0349 0.039 0.3131
Toxoplasma gondii heat shock protein HSP90 0.0349 0.039 0.2391
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0028 0.0028
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0191 0.0201 0.1612
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.012 0.0116 0.0116
Echinococcus multilocularis acetylcholinesterase 0.0422 0.0477 0.0477
Plasmodium falciparum thioredoxin reductase 0.0047 0.0029 0.0162
Trichomonas vaginalis D-aminoacylase, putative 0.0149 0.015 0.1351
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0179 0.0187 0.0187
Schistosoma mansoni nuclear hormone receptor 0.003 0.0008 0.0008
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0108 0.0102 0.0305
Brugia malayi hypothetical protein 0.0146 0.0147 0.1024
Entamoeba histolytica cysteine protease, putative 0.0026 0.0003 0.003
Loa Loa (eye worm) hypothetical protein 0.0027 0.0005 0.0033
Echinococcus granulosus nAChR subunit 0.005 0.0032 0.0032
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.005 0.0032 0.0032
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0121 0.0117 0.0308
Echinococcus multilocularis cathepsin l cysteine peptidase 0.005 0.0032 0.0032
Echinococcus multilocularis cysteine protease 0.005 0.0032 0.0032
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0062 0.0047 0.0375
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.005 0.0032 0.0032
Onchocerca volvulus Cathepsin L homolog 0.005 0.0032 0.029
Loa Loa (eye worm) hypothetical protein 0.0161 0.0165 0.1151
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0008 0.0058
Trypanosoma brucei transcription factor BTF3, putative 0.0034 0.0013 0.0104
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0008 0.0008
Echinococcus multilocularis zinc finger protein 0.0026 0.0003 0.0003
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0179 0.0187 0.0187
Echinococcus multilocularis endoplasmin 0.0241 0.026 0.026
Brugia malayi exodeoxyribonuclease III family protein 0.0055 0.0038 0.0265
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0108 0.0102 0.0263
Entamoeba histolytica hypothetical protein 0.0146 0.0147 0.1447
Echinococcus granulosus lamin dm0 0.0079 0.0066 0.0066
Brugia malayi kinase, mitochondrial precursor 0.0108 0.0102 0.071
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0106 0.0099 0.0253
Giardia lamblia Kinase, CMGC CLK 0.0062 0.0047 0.0528
Onchocerca volvulus 0.005 0.0032 0.029
Echinococcus multilocularis peregrin 0.0039 0.0019 0.0019
Brugia malayi Probable ClpP-like protease 0.0161 0.0165 0.1151
Trichomonas vaginalis ap endonuclease, putative 0.0055 0.0038 0.0341
Plasmodium falciparum acyl-CoA synthetase 0.009 0.008 0.0481
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.029 0.0319 0.0319
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0008 0.0058
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0046 0.0322
Trichomonas vaginalis antibiotic synthetase, putative 0.0035 0.0015 0.0131
Mycobacterium ulcerans aldehyde dehydrogenase 0.0179 0.0187 0.0559
Schistosoma mansoni cathepsin F (C01 family) 0.005 0.0032 0.0032
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.1064 0.1245 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0055 0.0038 0.0038
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0108 0.0102 0.0153
Echinococcus granulosus geminin 0.0502 0.0573 0.0573
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.005 0.0032 0.0226
Loa Loa (eye worm) hypothetical protein 0.0038 0.0018 0.0123
Trichomonas vaginalis heat shock protein, putative 0.0349 0.039 0.3511
Trichomonas vaginalis receptor histidine kinase, putative 0.0108 0.0102 0.0916
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0085 0.0074 0.0519
Mycobacterium tuberculosis Probable esterase LipL 0.0149 0.015 0.045
Brugia malayi GRF zinc finger family protein 0.0089 0.0078 0.0547
Echinococcus multilocularis glycine receptor subunit alpha 1 0.005 0.0032 0.0032
Echinococcus multilocularis heat shock protein 0.0349 0.039 0.039
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.0034 0.0196
Echinococcus multilocularis thyroid hormone receptor alpha 0.0155 0.0158 0.0158
Leishmania major DNA topoisomerase ii 0.0781 0.0908 0.7287
Mycobacterium ulcerans two component regulator - sensor kinase 0.0108 0.0102 0.0305
Echinococcus multilocularis BC026374 protein (S09 family) 0.0071 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0119 0.0114 0.0796
Onchocerca volvulus Cathepsin F homolog 0.005 0.0032 0.029
Brugia malayi Cytochrome P450 family protein 0.0027 0.0005 0.0035
Echinococcus granulosus dna polymerase kappa 0.0023 0.0000098932 0.0000098932
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0121 0.0117 0.035
Loa Loa (eye worm) hypothetical protein 0.0479 0.0545 0.3802
Entamoeba histolytica cysteine protease, putative 0.0026 0.0003 0.003
Loa Loa (eye worm) hypothetical protein 0.0027 0.0005 0.0033
Schistosoma mansoni gliotactin 0.0071 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.005 0.0032 0.0226
Loa Loa (eye worm) hypothetical protein 0.005 0.0032 0.0226
Brugia malayi glutathione reductase 0.0047 0.0029 0.0203
Loa Loa (eye worm) hypothetical protein 0.0302 0.0334 0.2328
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0008 0.0008
Plasmodium vivax vivapain-2 0.005 0.0032 0.0182
Trichomonas vaginalis receptor histidine kinase, putative 0.0108 0.0102 0.0916
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0032 0.0289
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0089 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0027 0.0005 0.0033
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0003 0.0024
Brugia malayi Papain family cysteine protease containing protein 0.005 0.0032 0.0225
Echinococcus multilocularis tumor protein p63 0.2052 0.2429 0.2429
Onchocerca volvulus 0.0079 0.0066 0.0598
Toxoplasma gondii heat shock protein 75, putative 0.0124 0.0121 0.0703
Schistosoma mansoni lipoxygenase 0.0083 0.0071 0.0071
Plasmodium vivax heat shock protein 90, putative 0.0124 0.0121 0.0733
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0191 0.0201 0.1612
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0121 0.0117 0.035
Loa Loa (eye worm) hypothetical protein 0.003 0.0008 0.0058
Onchocerca volvulus Putative nachr subunit 0.005 0.0032 0.0292
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0005 0.0035
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0087 0.0076 0.0684
Onchocerca volvulus 0.0035 0.0015 0.0132
Onchocerca volvulus 0.005 0.0032 0.0292
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.005 0.0032 0.0032
Plasmodium vivax basic transcription factor 3b, putative 0.0034 0.0013 0.0062
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0035 0.0015 0.0117
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0071 0.0058 0.0058
Brugia malayi acetyltransferase, GNAT family protein 0.029 0.0319 0.2224
Entamoeba histolytica cysteine protease, putative 0.0026 0.0003 0.003
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0066 0.0052 0.0112
Brugia malayi nuclear receptor NHR-88 0.003 0.0008 0.0058
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0008 0.0008
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0029 0.0162
Trypanosoma brucei DNA topoisomerase III, putative 0.0089 0.0078 0.0629
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0085 0.0074 0.0222
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0108 0.0102 0.0305
Schistosoma mansoni cathepsin F (C01 family) 0.005 0.0032 0.0032
Loa Loa (eye worm) heat shock protein 90 0.0349 0.039 0.272
Loa Loa (eye worm) jmjC domain-containing protein 0.0056 0.0039 0.0273
Loa Loa (eye worm) acetyltransferase 0.029 0.0319 0.2224
Schistosoma mansoni survival motor neuron protein 0.0249 0.027 0.027
Echinococcus granulosus para nitrobenzyl esterase 0.0071 0.0058 0.0058
Brugia malayi Pre-SET motif family protein 0.012 0.0116 0.0807
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0008 0.0008
Trypanosoma cruzi heat shock protein, putative 0.0124 0.0121 0.0967
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0008 0.0008
Entamoeba histolytica cysteine protease, putative 0.0026 0.0003 0.003
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.005 0.0032 0.0226
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0108 0.0102 0.0305
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0008 0.0008
Brugia malayi ecdysteroid receptor 0.003 0.0008 0.0058
Onchocerca volvulus 0.005 0.0032 0.029
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0108 0.0102 0.0407
Toxoplasma gondii DNA topoisomerase family protein 0.0089 0.0078 0.0439
Trypanosoma brucei RNA helicase, putative 0.0109 0.0102 0.0821
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0061 0.049
Schistosoma mansoni heat shock protein 0.0124 0.0121 0.0121
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0191 0.0201 0.1612
Brugia malayi Calcitonin receptor-like protein seb-1 0.0148 0.0149 0.1041
Leishmania major hypothetical protein, conserved 0.0052 0.0034 0.0276
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0191 0.0201 0.1612
Mycobacterium ulcerans esterase/lipase LipP 0.0149 0.015 0.045
Trichomonas vaginalis CK1 family protein kinase 0.0039 0.0019 0.017
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0035 0.0015 0.0044
Loa Loa (eye worm) TOPoisomerase family member 0.087 0.1014 0.7071
Brugia malayi beta-lactamase family protein 0.0149 0.015 0.1047
Trypanosoma cruzi casein kinase, putative 0.0039 0.0019 0.0152
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0731 0.0847 0.7624
Schistosoma mansoni nAChR subunit 0.005 0.0032 0.0032
Mycobacterium ulcerans DNA gyrase subunit B 0.0988 0.1155 0.3467
Brugia malayi jmjC domain containing protein 0.0212 0.0226 0.1574
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.332 0.3947 0.3947
Loa Loa (eye worm) hypothetical protein 0.0077 0.0065 0.0452
Echinococcus granulosus JmjC domain containing protein 4 0.0056 0.0039 0.0039
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0008 0.0008
Plasmodium falciparum DNA gyrase subunit A 0.1364 0.1605 1
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0108 0.0102 0.0817
Echinococcus granulosus FTZ F1 alpha 0.003 0.0008 0.0008
Schistosoma mansoni hypothetical protein 0.0502 0.0573 0.0573
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0035 0.0015 0.0117
Mycobacterium tuberculosis Probable dehydrogenase 0.0108 0.0102 0.0305
Onchocerca volvulus 0.0121 0.0117 0.105
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0034 0.0196
Mycobacterium tuberculosis Conserved protein 0.0108 0.0102 0.0305
Mycobacterium ulcerans acyl-CoA synthetase 0.0035 0.0015 0.0044
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0035 0.0015 0.0044
Echinococcus multilocularis cathepsin L 0.0026 0.0003 0.0003
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0108 0.0102 0.0102
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0108 0.0102 0.0616
Echinococcus granulosus casein kinase I alpha 0.0039 0.0019 0.0019
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.005 0.0032 0.0226
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0008 0.0058
Trypanosoma brucei cytochrome P450, putative 0.0027 0.0005 0.004
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0035 0.0015 0.0102
Trichomonas vaginalis penicillin-binding protein, putative 0.0149 0.015 0.1351
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0079 0.0079
Onchocerca volvulus 0.005 0.0032 0.029
Schistosoma mansoni hypothetical protein 0.0047 0.0028 0.0028
Entamoeba histolytica cysteine protease, putative 0.005 0.0032 0.0317
Echinococcus granulosus DNA topoisomerase 3 beta 1 0.0089 0.0078 0.0078
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0089 0.0078 0.0705
Leishmania major cathepsin L-like protease 0.0191 0.0201 0.1612
Trichomonas vaginalis ap endonuclease, putative 0.0055 0.0038 0.0341
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0028 0.0028
Mycobacterium ulcerans transcriptional regulator 0.2807 0.3332 1
Giardia lamblia DNA topoisomerase III 0.0089 0.0078 0.0886
Schistosoma mansoni hypothetical protein 0.0146 0.0147 0.0147
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0008 0.0008
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0046 0.0046
Schistosoma mansoni inositol monophosphatase 0.0074 0.0061 0.0061
Schistosoma mansoni protein kinase 0.0039 0.0019 0.0019
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0121 0.0117 0.0308
Brugia malayi AMP-binding enzyme family protein 0.0035 0.0015 0.0102
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0055 0.0038 0.0373
Echinococcus granulosus endoplasmin 0.0241 0.026 0.026
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0781 0.0908 0.7287
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.005 0.0032 0.0225
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0074 0.0061 0.0331
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0046 0.0046
Leishmania major heat shock protein 83-1 0.0349 0.039 0.3131
Entamoeba histolytica protein kinase, putative 0.0092 0.0082 0.0806
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.005 0.0032 0.0226
Echinococcus multilocularis beta LACTamase domain containing family member 0.0149 0.015 0.015
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0035 0.0015 0.0117
Entamoeba histolytica protein kinase domain containing protein 0.0092 0.0082 0.0806
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0085 0.0074 0.0222
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0022 0.0022
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.0312 0.2806
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0047 0.0421
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0731 0.0847 0.7624
Schistosoma mansoni nAChR subunit 0.005 0.0032 0.0032
Echinococcus granulosus cathepsin L 0.0026 0.0003 0.0003
Trypanosoma brucei DNA topoisomerase IA, putative 0.0089 0.0078 0.0629
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0032 0.0289
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0271 0.0296 0.0849
Echinococcus multilocularis ubiquitin specific protease 41 0.0038 0.0017 0.0017
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0055 0.0039 0.0222
Echinococcus multilocularis lamin 0.0079 0.0066 0.0066
Trypanosoma cruzi cysteine peptidase, putative 0.0191 0.0201 0.1612
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0035 0.0015 0.0044
Mycobacterium tuberculosis Possible two component sensor kinase 0.0108 0.0102 0.0305
Loa Loa (eye worm) hypothetical protein 0.005 0.0032 0.0226
Loa Loa (eye worm) hypothetical protein 0.0479 0.0545 0.3802
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0108 0.0102 0.0305
Echinococcus multilocularis heat shock protein 90 0.0349 0.039 0.039
Brugia malayi Niemann-Pick C1 protein precursor 0.0199 0.021 0.1467
Mycobacterium ulcerans aldehyde dehydrogenase 0.0179 0.0187 0.0559
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0179 0.0187 0.0559
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0136 0.0135 0.0135
Leishmania major heat shock protein 83-1 0.0349 0.039 0.3131
Loa Loa (eye worm) hypothetical protein 0.0056 0.0039 0.0273
Leishmania major 4-coumarate:coa ligase-like protein 0.0121 0.0117 0.0936
Echinococcus multilocularis peptidase Clp (S14 family) 0.0106 0.0099 0.0099
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.005 0.0032 0.0226
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0039 0.0019 0.0132
Echinococcus granulosus histone acetyltransferase KAT2B 0.0279 0.0306 0.0306
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0008 0.0075
Trichomonas vaginalis CK1 family protein kinase 0.0039 0.0019 0.017
Trichomonas vaginalis sensor histidine kinase, putative 0.0108 0.0102 0.0916
Plasmodium vivax acyl-CoA synthetase, putative 0.009 0.008 0.0481
Echinococcus multilocularis heat shock protein 90 0.0241 0.026 0.026
Leishmania major heat shock protein 83-1 0.0349 0.039 0.3131
Chlamydia trachomatis DNA gyrase subunit A 0.0262 0.0285 0.1357
Treponema pallidum DNA topoisomerase I (topA) 0.0089 0.0078 0.0258
Plasmodium falciparum cysteine proteinase falcipain 2b 0.005 0.0032 0.0182
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0000098932 0.0000098932
Plasmodium falciparum glutathione reductase 0.0047 0.0029 0.0162
Mycobacterium ulcerans acyl-CoA synthetase 0.0035 0.0015 0.0044
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.012 0.0116 0.0349
Loa Loa (eye worm) hypothetical protein 0.0027 0.0005 0.0033
Echinococcus multilocularis casein kinase i 0.0039 0.0019 0.0019
Leishmania major trypanothione reductase 0.0047 0.0029 0.0232
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0008 0.0008
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0146 0.0147 0.0147
Onchocerca volvulus 0.0071 0.0058 0.0518
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0079 0.0079
Schistosoma mansoni nAChR subunit 0.005 0.0032 0.0032
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0108 0.0102 0.0305
Loa Loa (eye worm) hypothetical protein 0.0121 0.0117 0.0813
Trichomonas vaginalis DNA topoisomerase II, putative 0.087 0.1014 0.9128
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0191 0.0201 0.1612
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0284 0.0312 0.3074
Echinococcus granulosus lamin 0.0079 0.0066 0.0066
Loa Loa (eye worm) CYP4Cod1 0.0027 0.0005 0.0035
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.005 0.0032 0.0289
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0008 0.0008
Schistosoma mansoni endoplasmin 0.0349 0.039 0.039
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0000098932 0.0000098932
Plasmodium vivax JmjC domain containing protein 0.0056 0.0039 0.0225
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0118 0.0114 0.0114
Mycobacterium ulcerans acyl-CoA synthetase 0.0035 0.0015 0.0044
Schistosoma mansoni hypothetical protein 0.003 0.0008 0.0008
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0055 0.0038 0.0304
Trypanosoma brucei heat shock protein, putative 0.0349 0.039 0.3131
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0161 0.0165 0.0567
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0179 0.0187 0.1497
Entamoeba histolytica heat shock protein 90, putative 0.0349 0.039 0.3846
Echinococcus granulosus dual specificity 0.0092 0.0082 0.0082
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0161 0.0165 0.0982
Loa Loa (eye worm) hypothetical protein 0.0023 0.0000098932 0.0001
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0092 0.0082 0.0656
Schistosoma mansoni acetylcholinesterase 0.0071 0.0058 0.0058
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0148 0.0149 0.1041
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0008 0.0058
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0038 0.0018 0.0018
Leishmania major heat shock protein 83-1 0.0349 0.039 0.3131
Brugia malayi Probable DNA topoisomerase II 0.087 0.1014 0.7071
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0056 0.0039 0.0194
Entamoeba histolytica cysteine proteinase 1, putative 0.0026 0.0003 0.003
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0136 0.0135 0.0135
Mycobacterium leprae Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0419 0.0473 0.1383
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0108 0.0102 0.0916
Loa Loa (eye worm) hypothetical protein 0.0069 0.0054 0.0379
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0035 0.0015 0.0044
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.005 0.0032 0.0032
Entamoeba histolytica heat shock protein 90, putative 0.0349 0.039 0.3846
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0008 0.0058
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.005 0.0032 0.0226
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0079 0.0079

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = -4.16 Compound was tested for the in silico inhibition of acetylcholinesterase ChEMBL. 14643329
IC50 (binding) = 10.3 uM In vitro anticholinesterase activity of the compound was determined against butyrylcholinesterase from torpedo californica ChEMBL. 14584959
IC50 (binding) = 10.3 uM In vitro anticholinesterase activity of the compound was determined against butyrylcholinesterase from torpedo californica ChEMBL. 14584959
IC50 (binding) = 69.9 uM In vitro anticholinesterase activity was determined against acetylcholinesterase from Torpedo californica ChEMBL. 14584959
IC50 (binding) = 69.9 uM In vitro anticholinesterase activity was determined against acetylcholinesterase from Torpedo californica ChEMBL. 14584959
Ki (binding) = 7.5 uM In vitro binding affinity was determined against butyrylcholinesterase from torpedo californica ChEMBL. 14584959
Ki (binding) = 7.5 uM In vitro binding affinity was determined against butyrylcholinesterase from torpedo californica ChEMBL. 14584959
Ki (binding) = 90.3 uM In vitro binding affinity was determined against acetylcholinesterase from torpedo californica ChEMBL. 14584959
Ki (binding) = 90.3 uM In vitro binding affinity was determined against acetylcholinesterase from torpedo californica ChEMBL. 14584959
Log IC50 (binding) = 4.16 Compound was tested for the in silico inhibition of acetylcholinesterase ChEMBL. 14643329

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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