Detailed information for compound 349163

Basic information

Technical information
  • TDR Targets ID: 349163
  • Name: methyl 4-[2-amino-3,5-dicyano-6-(4-methoxycar bonylphenyl)sulfanylpyridin-4-yl]benzoate
  • MW: 444.463 | Formula: C23H16N4O4S
  • H donors: 1 H acceptors: 5 LogP: 4.23 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1ccc(cc1)Sc1nc(N)c(c(c1C#N)c1ccc(cc1)C(=O)OC)C#N
  • InChi: 1S/C23H16N4O4S/c1-30-22(28)14-5-3-13(4-6-14)19-17(11-24)20(26)27-21(18(19)12-25)32-16-9-7-15(8-10-16)23(29)31-2/h3-10H,1-2H3,(H2,26,27)
  • InChiKey: PQQYXICETZSLNY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • methyl 4-[2-amino-3,5-dicyano-6-(4-methoxycarbonylphenyl)sulfanyl-4-pyridyl]benzoate
  • 4-[2-amino-3,5-dicyano-6-[(4-methoxycarbonylphenyl)thio]-4-pyridyl]benzoic acid methyl ester
  • methyl 4-[2-azanyl-3,5-dicyano-6-(4-methoxycarbonylphenyl)sulfanyl-pyridin-4-yl]benzoate
  • 4-[2-amino-6-[(4-carbomethoxyphenyl)thio]-3,5-dicyano-4-pyridyl]benzoic acid methyl ester
  • methyl 4-[2-amino-3,5-dicyano-6-(4-methoxycarbonylphenyl)sulfanyl-pyridin-4-yl]benzoate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0025 0.0091 0.0199
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0046 0.2551
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0083
Brugia malayi Metabotropic glutamate receptor precursor. 0.01 0.068 0.114
Brugia malayi Immunoglobulin I-set domain containing protein 0.0039 0.02 0.0333
Trichomonas vaginalis synaptotagmin, putative 0.0019 0.0046 0.2551
Echinococcus granulosus geminin 0.0123 0.0858 0.1878
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0037 0.0182 0.0925
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0039 0.02 0.0439
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.002 0.0055 0.0565
Echinococcus multilocularis C2 calcium lipid binding region, CaLB 0.0019 0.0046 0.0046
Onchocerca volvulus 0.002 0.0055 1
Echinococcus granulosus Protein patched homolog 1 0.0036 0.0181 0.0395
Trichomonas vaginalis synaptotagmin, putative 0.0019 0.0046 0.2551
Schistosoma mansoni protein kinase C 0.0019 0.0046 0.0101
Toxoplasma gondii thioredoxin reductase 0.0034 0.0163 0.0199
Leishmania major phospholipase c-like protein 0.0019 0.0046 0.0224
Entamoeba histolytica acyl-CoA synthetase, putative 0.002 0.0055 0.0173
Loa Loa (eye worm) hypothetical protein 0.0015 0.0014 0.0022
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0046 0.0101
Echinococcus multilocularis copine 9 0.0019 0.0046 0.0046
Toxoplasma gondii acyl-CoA dehydrogenase, middle domain-containing protein 0.077 0.5947 1
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0046 0.2551
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0025 0.0091 0.0091
Brugia malayi Acyl-CoA oxidase family protein 0.077 0.5947 1
Brugia malayi C2 domain containing protein 0.0019 0.0046 0.0073
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0229 0.0501
Trypanosoma brucei predicted C2 domain protein 0.0019 0.0046 0.0224
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0019 0.0046 0.0101
Loa Loa (eye worm) hypothetical protein 0.0123 0.0862 0.1655
Trypanosoma cruzi acyl-CoA oxidase, putative 0.0092 0.0619 0.3183
Schistosoma mansoni hypothetical protein 0.0025 0.0091 0.0199
Leishmania major c2 domain protein, putative 0.0019 0.0046 0.0224
Echinococcus multilocularis Immunoglobulin 0.0039 0.02 0.02
Echinococcus granulosus neuroglian 0.0039 0.02 0.0439
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0019 0.0046 0.0083
Brugia malayi Variant SH3 domain containing protein 0.0019 0.0046 0.0073
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0083
Echinococcus granulosus GPCR family 2 0.0025 0.0091 0.0199
Loa Loa (eye worm) hypothetical protein 0.0025 0.0091 0.017
Schistosoma mansoni hypothetical protein 0.0054 0.0319 0.0698
Plasmodium vivax glutathione reductase, putative 0.0034 0.0163 0.3637
Loa Loa (eye worm) hypothetical protein 0.0045 0.0245 0.0467
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0071 0.0455 0.0761
Echinococcus multilocularis Niemann Pick C1 protein 0.0085 0.0561 0.0561
Loa Loa (eye worm) apoptosis regulator protein 0.0071 0.0455 0.0872
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0229 0.0436
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.002 0.0055 0.0565
Trypanosoma cruzi transcription factor btf3, putative 0.003 0.0131 0.0663
Mycobacterium tuberculosis Probable oxidoreductase 0.0087 0.0576 0.5929
Echinococcus multilocularis synaptotagmin 2 0.0019 0.0046 0.0046
Echinococcus multilocularis copine 9 0.0019 0.0046 0.0046
Schistosoma mansoni apoptosis regulator bax 0.0071 0.0455 0.0997
Schistosoma mansoni synaptotagmin 0.0019 0.0046 0.0101
Echinococcus granulosus GPCR family 3 C terminal 0.0016 0.0022 0.0048
Echinococcus multilocularis synaptotagmin 15 0.0019 0.0046 0.0046
Echinococcus granulosus unc 13 munc13 0.0019 0.0046 0.0101
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0083
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0025 0.0091 0.0091
Onchocerca volvulus 0.0019 0.0046 0.7307
Echinococcus granulosus Immunoglobulin 0.0039 0.02 0.0439
Schistosoma mansoni synaptotagmin 12 0.0019 0.0046 0.0101
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0013 0 0.5
Echinococcus granulosus synaptotagmin 0.0019 0.0046 0.0101
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0083
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0008 0.008
Brugia malayi C2 domain containing protein 0.0019 0.0046 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0181 1
Mycobacterium ulcerans acyl-CoA dehydrogenase 0.0096 0.0647 0.6658
Schistosoma mansoni synaptotagmin 0.0019 0.0046 0.0101
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0015 0.0014 0.0148
Trichomonas vaginalis copine, putative 0.0019 0.0046 0.2551
Schistosoma mansoni microtubule-associated protein tau 0.0595 0.4569 1
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0019 0.0046 0.0046
Toxoplasma gondii perforin-like protein PLP1 0.0067 0.0424 0.064
Plasmodium vivax double C2-like domain-containing protein, putative 0.0019 0.0046 0.0774
Echinococcus multilocularis protein piccolo 0.0019 0.0046 0.0046
Mycobacterium ulcerans acyl-CoA synthetase 0.002 0.0055 0.0565
Loa Loa (eye worm) hypothetical protein 0.0021 0.0058 0.0107
Plasmodium falciparum ferlin, putative 0.0019 0.0046 0.0774
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0046 0.2551
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0071 0.0455 0.0997
Trypanosoma cruzi synaptotagmin, putative 0.0019 0.0046 0.0224
Brugia malayi C2 domain containing protein 0.0019 0.0046 0.0073
Echinococcus granulosus metabotropic glutamate receptor 2 0.0084 0.0553 0.121
Schistosoma mansoni synaptotagmin 0.0019 0.0046 0.0101
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0055 0.0565
Trypanosoma cruzi trypanothione reductase, putative 0.0034 0.0163 0.0829
Trichomonas vaginalis annexin VII, putative 0.0019 0.0046 0.2551
Echinococcus multilocularis myoferlin 0.0019 0.0046 0.0046
Leishmania major mitochondrial DNA polymerase beta 0.026 0.194 1
Schistosoma mansoni hypothetical protein 0.0019 0.0046 0.0101
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0019 0.0046 0.0101
Echinococcus granulosus transcription factor btf3 0.003 0.0131 0.0287
Loa Loa (eye worm) latrophilin receptor protein 2 0.0025 0.0091 0.017
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0083
Trypanosoma brucei trypanothione reductase 0.0034 0.0163 0.0829
Plasmodium falciparum basic transcription factor 3b, putative 0.003 0.0131 0.2854
Echinococcus multilocularis 0.0019 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.002 0.0055 0.0101
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0037 0.0182 0.0925
Brugia malayi Synapse defective protein 1 0.0019 0.0046 0.0073
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0078 0.0508 0.5225
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0083
Schistosoma mansoni nephrin 0.0039 0.02 0.0439
Echinococcus multilocularis C2 calcium lipid binding region, CaLB 0.0019 0.0046 0.0046
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0024 0.0083 0.0135
Loa Loa (eye worm) acyl-CoA oxidase 0.0475 0.3627 0.6982
Loa Loa (eye worm) hypothetical protein 0.0039 0.02 0.0381
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0019 0.0046 0.0101
Onchocerca volvulus 0.0019 0.0046 0.7307
Trypanosoma brucei acyl-CoA oxidase, putative 0.0092 0.0619 0.3183
Echinococcus granulosus intersectin 2 0.0019 0.0046 0.0101
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0019 0.0046 0.0083
Trypanosoma brucei cAMP binding protein, putative 0.0022 0.0071 0.0352
Treponema pallidum bacterioferrin (TpF1) 0.0013 0 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0046 0.2551
Brugia malayi AMP-binding enzyme family protein 0.002 0.0055 0.0088
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0046 0.2551
Loa Loa (eye worm) hypothetical protein 0.0039 0.02 0.0381
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0046 0.2551
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0016 0.0022 0.0032
Schistosoma mansoni patched 1 0.0036 0.0181 0.0395
Trypanosoma cruzi cAMP binding protein, putative 0.0022 0.0071 0.0352
Loa Loa (eye worm) ICD-1 protein 0.003 0.0131 0.0247
Toxoplasma gondii hypothetical protein 0.0042 0.0224 0.0302
Plasmodium vivax ferlin, putative 0.0019 0.0046 0.0774
Brugia malayi Synaptotagmin protein 3 0.0019 0.0046 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0102 0.5658
Trypanosoma brucei C2 domain containing protein, putative 0.0019 0.0046 0.0224
Echinococcus granulosus neural cell expressed developmentally 0.0019 0.0046 0.0101
Trichomonas vaginalis synaptotagmin 1, 3, C.elegans, putative 0.0019 0.0046 0.2551
Schistosoma mansoni jumonji domain containing protein 0.0043 0.0229 0.0501
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0083
Schistosoma mansoni transcription factor btf3 0.003 0.0131 0.0287
Mycobacterium ulcerans hypothetical protein 0.002 0.0055 0.0565
Echinococcus granulosus copine 9 0.0019 0.0046 0.0101
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0123 0.0863 0.4438
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0046 0.0224
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0046 0.2551
Echinococcus granulosus thioredoxin glutathione reductase 0.0034 0.0163 0.0357
Trichomonas vaginalis copine, putative 0.0019 0.0046 0.2551
Trypanosoma cruzi synaptotagmin, putative 0.0019 0.0046 0.0224
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0046 0.2551
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0046 0.2551
Echinococcus multilocularis protein dispatched 1 0.0042 0.0221 0.0221
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0019 0.0046 0.0046
Loa Loa (eye worm) thioredoxin reductase 0.0034 0.0163 0.0309
Leishmania major basic transcription factor 3a, putative 0.003 0.0131 0.0663
Echinococcus granulosus otoferlin 0.0019 0.0046 0.0101
Loa Loa (eye worm) synaptotagmin-1 0.0019 0.0046 0.0083
Loa Loa (eye worm) hypothetical protein 0.0054 0.0319 0.0609
Echinococcus multilocularis intersectin 2 0.0019 0.0046 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0046 0.2551
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0019 0.0046 0.0101
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0019 0.0046 0.2551
Loa Loa (eye worm) hypothetical protein 0.0085 0.0561 0.1076
Brugia malayi Fibronectin type III domain containing protein 0.0039 0.02 0.0333
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0036 0.0181 0.0343
Leishmania major hypothetical protein, conserved 0.0019 0.0046 0.0224
Trypanosoma cruzi C2 domain/Ankyrin repeats (3 copies), putative 0.0019 0.0046 0.0224
Loa Loa (eye worm) hypothetical protein 0.0674 0.5194 1
Brugia malayi jmjC domain containing protein 0.0043 0.0229 0.038
Schistosoma mansoni rho gtpase activating protein 0.0019 0.0046 0.0101
Schistosoma mansoni metabotropic glutamate receptor 0.0049 0.0277 0.0607
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0114 0.0788 0.1724
Echinococcus granulosus Niemann Pick C1 protein 0.0085 0.0561 0.1228
Onchocerca volvulus 0.0019 0.0046 0.7307
Brugia malayi C2 domain containing protein 0.0019 0.0046 0.0073
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0019 0.0046 0.0046
Echinococcus granulosus C2 calcium lipid binding region CaLB 0.0019 0.0046 0.0101
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0024 0.0083 0.0182
Onchocerca volvulus 0.0019 0.0046 0.7307
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0037 0.0182 0.0925
Trypanosoma cruzi small ubiquitin protein, putative 0.0026 0.0102 0.0513
Echinococcus granulosus synaptotagmin 15 0.0019 0.0046 0.0101
Schistosoma mansoni unc-13 (munc13) 0.0019 0.0046 0.0101
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0019 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0083
Echinococcus multilocularis GPCR, family 3, C terminal 0.0016 0.0022 0.0022
Loa Loa (eye worm) C2 domain-containing protein 0.0019 0.0046 0.0083
Loa Loa (eye worm) glutathione reductase 0.0034 0.0163 0.0309
Leishmania major hypothetical protein, conserved 0.0022 0.0071 0.0352
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0083
Schistosoma mansoni hypothetical protein 0.0123 0.0858 0.1878
Echinococcus granulosus extended synaptotagmin 2 0.0019 0.0046 0.0101
Plasmodium vivax basic transcription factor 3b, putative 0.003 0.0131 0.2854
Schistosoma mansoni voltage-gated potassium channel 0.0026 0.01 0.0219
Loa Loa (eye worm) hypothetical protein 0.0015 0.0014 0.0022
Plasmodium falciparum glutathione reductase 0.0034 0.0163 0.3637
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0008 0.008
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0045 0.0245 0.125
Brugia malayi C2 domain containing protein 0.0019 0.0046 0.0073
Trypanosoma cruzi C2 domain containing protein, putative 0.0019 0.0046 0.0224
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0083
Trichomonas vaginalis vab10 spectraplakin, putative 0.0019 0.0046 0.2551
Trypanosoma brucei hypothetical protein, conserved 0.0019 0.0046 0.0224
Echinococcus granulosus calpain 5 0.0019 0.0046 0.0101
Brugia malayi phospholipase C homolog 0.0019 0.0046 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0046 0.2551
Trichomonas vaginalis synaptotagmin, putative 0.0019 0.0046 0.2551
Echinococcus granulosus synaptotagmin 0.0019 0.0046 0.0101
Trichomonas vaginalis copine, putative 0.0019 0.0046 0.2551
Echinococcus multilocularis NEDD4 E3 ubiquitin protein ligase WWP1 0.0019 0.0046 0.0046
Loa Loa (eye worm) C2 domain-containing protein 0.0019 0.0046 0.0083
Onchocerca volvulus Putative cc2d1b protein 0.0019 0.0046 0.7307
Schistosoma mansoni Mername-AA248 (C02 family) 0.0019 0.0046 0.0101
Echinococcus multilocularis synaptotagmin 0.0019 0.0046 0.0046
Entamoeba histolytica acyl-coA synthetase, putative 0.002 0.0055 0.0173
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0083
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0019 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.002 0.0055 0.0101
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0046 0.0224
Brugia malayi protein kinase C II. 0.0019 0.0046 0.0073
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.002 0.0055 0.0887
Schistosoma mansoni otoferlin 0.0019 0.0046 0.0101
Toxoplasma gondii small ubiquitin family modifier, putative 0.0026 0.0102 0.0095
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0014 0.0003 0.0028
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0042 0.0228 0.0434
Echinococcus granulosus protein piccolo 0.0019 0.0046 0.0101
Mycobacterium ulcerans acyl-CoA synthetase 0.002 0.0055 0.0565
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0085 0.0561 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0046 0.2551
Plasmodium vivax ferlin, putative 0.0019 0.0046 0.0774
Leishmania major hypothetical protein, conserved 0.0019 0.0046 0.0224
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0083
Echinococcus granulosus C2 calcium lipid binding region CaLB 0.0019 0.0046 0.0101
Loa Loa (eye worm) C2 domain-containing protein 0.0019 0.0046 0.0083
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0008 0.008
Plasmodium falciparum double C2-like domain-containing protein 0.0019 0.0046 0.0774
Schistosoma mansoni hypothetical protein 0.0035 0.017 0.0373
Loa Loa (eye worm) Nedd4-PD 0.0019 0.0046 0.0083
Trypanosoma cruzi acyl-CoA oxidase, putative 0.0092 0.0619 0.3183
Brugia malayi calpain 5 0.0019 0.0046 0.0073
Trypanosoma brucei predicted C2 domain protein 0.0019 0.0046 0.0224
Trichomonas vaginalis synaptotagmin, putative 0.0019 0.0046 0.2551
Loa Loa (eye worm) hypothetical protein 0.0039 0.02 0.0381
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0046 0.0073
Echinococcus granulosus Immunoglobulin E set 0.0019 0.0046 0.0101
Brugia malayi C2 domain containing protein 0.0019 0.0046 0.0073
Schistosoma mansoni hypothetical protein 0.0071 0.0455 0.0997
Brugia malayi C2 domain containing protein 0.0019 0.0046 0.0073
Loa Loa (eye worm) hypothetical protein 0.0016 0.0022 0.0037
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0019 0.0046 0.0083
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0083
Loa Loa (eye worm) copine family protein 0.0019 0.0046 0.0083
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0086 0.0572 0.1251
Brugia malayi Immunoglobulin I-set domain containing protein 0.0042 0.0228 0.0379
Brugia malayi Copine VIII 0.0019 0.0046 0.0073
Plasmodium vivax perforin-like protein 4 0.0067 0.0424 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.026 0.194 1
Leishmania major 4-coumarate:coa ligase-like protein 0.002 0.0055 0.0269
Onchocerca volvulus 0.0019 0.0046 0.7307
Loa Loa (eye worm) hypothetical protein 0.0039 0.02 0.0381
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0025 0.0091 0.0199
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0083
Schistosoma mansoni hypothetical protein 0.0123 0.0858 0.1878
Echinococcus multilocularis synaptotagmin 0.0019 0.0046 0.0046
Trichomonas vaginalis calcium-dependent lipid-binding protein, putative 0.0019 0.0046 0.2551
Loa Loa (eye worm) C2 domain-containing protein 0.0019 0.0046 0.0083
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0046 0.0224
Echinococcus multilocularis roundabout 2 0.0039 0.02 0.02
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0024 0.0083 0.0083
Brugia malayi Protein kinase c protein 2 0.0019 0.0046 0.0073
Loa Loa (eye worm) glutamate receptor 0.0039 0.0204 0.0387
Brugia malayi glutathione reductase 0.0034 0.0163 0.027
Echinococcus granulosus synaptotagmin 2 0.0019 0.0046 0.0101
Brugia malayi CHE-14 protein 0.0036 0.0181 0.0299
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0034 0.0163 0.168
Loa Loa (eye worm) C2 domain-containing protein 0.0019 0.0046 0.0083
Trypanosoma brucei C2 domain/Ankyrin repeats (3 copies), putative 0.0019 0.0046 0.0224
Leishmania major small ubiquitin protein, putative 0.0026 0.0102 0.0513
Echinococcus multilocularis 1 phosphatidylinositol 4,5 bisphosphate 0.0019 0.0046 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0046 0.2551
Schistosoma mansoni unc-13 (munc13) 0.0019 0.0046 0.0101
Brugia malayi Synaptotagmin I 0.0019 0.0046 0.0073
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0046 0.0101
Toxoplasma gondii NAC domain-containing protein 0.003 0.0131 0.0144
Brugia malayi Synapse defective protein 1 0.0019 0.0046 0.0073
Toxoplasma gondii MAC/Perforin domain-containing protein 0.0067 0.0424 0.064
Brugia malayi Calcitonin receptor-like protein seb-1 0.0079 0.0516 0.0863
Trypanosoma brucei predicted C2 domain protein 0.0019 0.0046 0.0224
Schistosoma mansoni E3 ubiquitin-protein ligase nedd-4 0.0019 0.0046 0.0101
Echinococcus granulosus synaptotagmin protein 4 0.0019 0.0046 0.0101
Trypanosoma cruzi small ubiquitin protein, putative 0.0026 0.0102 0.0513
Echinococcus multilocularis unc 13 (munc13) 0.0019 0.0046 0.0046
Leishmania major hypothetical protein, conserved 0.0019 0.0046 0.0224
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0046 0.2551
Loa Loa (eye worm) hypothetical protein 0.0036 0.0181 0.0343
Entamoeba histolytica ubiquitin like protein 0.0026 0.0102 0.1089
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0046 0.0224
Trichomonas vaginalis copine, putative 0.0019 0.0046 0.2551
Onchocerca volvulus 0.0019 0.0046 0.7307
Echinococcus granulosus active breakpoint cluster region 0.0019 0.0046 0.0101
Brugia malayi NEDD4.2 0.0019 0.0046 0.0073
Echinococcus multilocularis thioredoxin glutathione reductase 0.0034 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0039 0.02 0.0381
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0037 0.0182 0.0925
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0046 0.2551
Leishmania major hypothetical protein, conserved 0.0019 0.0046 0.0224
Trichomonas vaginalis synaptotagmin 1, 3, C.elegans, putative 0.0019 0.0046 0.2551
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0131 0.7266
Schistosoma mansoni synaptotagmin-like protein 0.0019 0.0046 0.0101
Echinococcus multilocularis macrophage expressed protein 0.0067 0.0424 0.0424
Chlamydia trachomatis hypothetical protein 0.0067 0.0424 1
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0046 0.2551
Schistosoma mansoni hypothetical protein 0.0071 0.0455 0.0997
Trichomonas vaginalis Proline-rich protein, putative 0.0019 0.0046 0.2551
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0079 0.0516 0.0863
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0046 0.2551
Entamoeba histolytica hypothetical protein 0.003 0.0131 0.1652
Schistosoma mansoni rab3 interacting molecule (rim)-related 0.0019 0.0046 0.0101
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0046 0.2551
Loa Loa (eye worm) SMO-1 protein 0.0026 0.0102 0.0192
Schistosoma mansoni nedd-4-like E3 ubiquitin-protein ligase 0.0019 0.0046 0.0101
Schistosoma mansoni vesicular amine transporter 0.0041 0.0213 0.0466
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0087 0.0576 0.5929
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0046 0.2551
Loa Loa (eye worm) C2 domain-containing protein 0.0019 0.0046 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0046 0.2551
Leishmania major trypanothione reductase 0.0034 0.0163 0.0829
Echinococcus multilocularis multiple C2 and transmembrane domain containing protein 0.0019 0.0046 0.0046
Schistosoma mansoni ubiquitin-like protein sumo/smt3-related 0.0026 0.0102 0.0224
Echinococcus multilocularis extended synaptotagmin 2 0.0019 0.0046 0.0046
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0071 0.0455 0.0455
Echinococcus multilocularis Small ubiquitin modifier 2 0.0026 0.0102 0.0102
Plasmodium vivax perforin-like protein 3 0.0067 0.0424 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0087 0.0576 0.9303
Echinococcus granulosus NEDD4 E3 ubiquitin protein ligase WWP1 0.0019 0.0046 0.0101
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0079 0.0516 0.0988
Schistosoma mansoni synaptotagmin 0.0019 0.0046 0.0101
Brugia malayi AMP-binding enzyme family protein 0.002 0.0055 0.0088
Echinococcus granulosus synaptotagmin 0.0019 0.0046 0.0101
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0131 0.7266
Mycobacterium leprae conserved hypothetical protein 0.0092 0.0619 1
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0046 0.2551
Leishmania major c2 domain protein, putative 0.0019 0.0046 0.0224
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0046 0.2551
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0039 0.02 0.0439
Schistosoma mansoni hypothetical protein 0.0025 0.0091 0.0199
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0083
Entamoeba histolytica acyl-CoA synthetase, putative 0.002 0.0055 0.0173
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0083
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0043 0.0229 0.0501
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0022 0.0071 0.3907
Plasmodium falciparum perforin-like protein 1 0.0067 0.0424 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0008 0.008
Echinococcus multilocularis GPCR, family 2 0.0025 0.0091 0.0091
Brugia malayi metabotropic glutamate receptor type 2 0.0049 0.0277 0.0462
Echinococcus multilocularis synaptotagmin protein 4 0.0019 0.0046 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0046 0.2551
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0043 0.0229 0.0229
Brugia malayi C2 domain containing protein 0.0019 0.0046 0.0073
Trypanosoma cruzi cytoskeleton associated protein, putative 0.0019 0.0046 0.0224
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0083
Loa Loa (eye worm) hypothetical protein 0.0079 0.0516 0.0988
Echinococcus granulosus metabotropic glutamate receptor 5 0.0123 0.0862 0.1886
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0026 0.0096 0.0179
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0024 0.0083 0.0154
Brugia malayi beta-NAC-like protein 0.003 0.0131 0.0216
Leishmania major hypothetical protein, conserved 0.0019 0.0046 0.0224
Echinococcus multilocularis neuroglian 0.0039 0.02 0.02
Trichomonas vaginalis synaptotagmin 1,2, putative 0.0019 0.0046 0.2551
Plasmodium vivax thioredoxin reductase, putative 0.0034 0.0163 0.3637
Echinococcus granulosus protein kinase C gamma type 0.0019 0.0046 0.0101
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0015 0.0014 0.0148
Echinococcus granulosus macrophage expressed protein 0.0067 0.0424 0.0928
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0071 0.0455 0.0997
Onchocerca volvulus Multiple C2 domain and transmembrane region protein homolog 0.0019 0.0046 0.7307
Echinococcus multilocularis synaptotagmin 0.0019 0.0046 0.0046
Echinococcus multilocularis Immunoglobulin 0.0039 0.02 0.02
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0229 0.0501
Echinococcus granulosus copine 9 0.0019 0.0046 0.0101
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.026 0.194 1
Trichomonas vaginalis synaptotagmin, putative 0.0019 0.0046 0.2551
Echinococcus granulosus Protein kinase C brain isozyme 0.0019 0.0046 0.0101
Brugia malayi C2 domain containing protein 0.0019 0.0046 0.0073
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.002 0.0055 0.0565
Loa Loa (eye worm) hypothetical protein 0.0015 0.0014 0.0022
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0078 0.0508 0.5225
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.002 0.0055 0.0565
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0123 0.0862 0.0862
Echinococcus granulosus synaptotagmin 0.0019 0.0046 0.0101
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0022 0.0071 0.3907
Echinococcus granulosus myoferlin 0.0019 0.0046 0.0101
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0131 0.7266
Schistosoma mansoni hypothetical protein 0.0019 0.0046 0.0101
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0078 0.0508 0.5225
Echinococcus granulosus sterol regulatory element binding protein 0.0036 0.0181 0.0395
Trypanosoma brucei Coiled-coil and C2 domain-containing protein 0.0019 0.0046 0.0224
Trypanosoma brucei mitochondrial DNA polymerase beta 0.026 0.194 1
Echinococcus granulosus protein kinase c epsilon type 0.0019 0.0046 0.0101
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0046 0.0101
Brugia malayi hypothetical protein 0.0092 0.0619 0.1038
Trichomonas vaginalis synaptotagmin, putative 0.0019 0.0046 0.2551
Giardia lamblia Sentrin 0.0026 0.0102 0.5
Trichomonas vaginalis ion channel nompc, putative 0.0019 0.0046 0.2551
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0229 0.0501
Plasmodium falciparum perforin-like protein 2 0.0067 0.0424 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0083
Brugia malayi Thioredoxin reductase 0.0034 0.0163 0.027
Brugia malayi latrophilin 2 splice variant baaae 0.0054 0.0319 0.0532
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0078 0.0508 0.5225
Schistosoma mansoni metabotropic glutamate receptor 0.0084 0.0553 0.121
Trypanosoma brucei phosphoinositide-specific phospholipase C 0.0019 0.0046 0.0224
Echinococcus granulosus multiple C2 and transmembrane domain containing protein 0.0019 0.0046 0.0101
Schistosoma mansoni hypothetical protein 0.0035 0.017 0.0373
Plasmodium vivax small ubiquitin-related modifier, putative 0.0026 0.0102 0.2145
Schistosoma mansoni phospholipase C-like protein 2 plc-L2 0.0019 0.0046 0.0101
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0123 0.0863 0.4438
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0019 0.0046 0.0073
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0078 0.0508 0.8198
Brugia malayi hypothetical protein 0.0039 0.02 0.0333
Trypanosoma brucei C2 domain containing protein, putative 0.0019 0.0046 0.0224
Leishmania major 4-coumarate:coa ligase-like protein 0.002 0.0055 0.0269
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0071 0.0455 0.0455
Schistosoma mansoni hypothetical protein 0.0025 0.0091 0.0199
Loa Loa (eye worm) phosphatidylinositol 3-kinase catalytic subunit gamma 0.0019 0.0046 0.0083
Loa Loa (eye worm) hypothetical protein 0.0071 0.0455 0.0872
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0046 0.0224
Schistosoma mansoni glut4 vesicle protein-related 0.0019 0.0046 0.0101
Echinococcus granulosus twitchin 0.0039 0.02 0.0439
Echinococcus granulosus UNCoordinated family member unc 13 0.0019 0.0046 0.0101
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0019 0.0046 0.0101
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0084 0.0553 0.0553
Brugia malayi Latrophilin receptor protein 2 0.0025 0.0091 0.0148
Plasmodium falciparum perforin-like protein 3 0.0067 0.0424 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0137 0.0972 1
Plasmodium vivax perforin-like protein 5 0.0067 0.0424 1
Trypanosoma cruzi cytoskeleton associated protein, putative 0.0019 0.0046 0.0224
Schistosoma mansoni hypothetical protein 0.0067 0.0424 0.0928
Mycobacterium ulcerans acyl-CoA synthetase 0.002 0.0055 0.0565
Echinococcus multilocularis synaptotagmin 0.0019 0.0046 0.0046
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0091 0.0606 0.1015
Loa Loa (eye worm) hypothetical protein 0.0015 0.0014 0.0022
Echinococcus multilocularis UNCoordinated family member (unc 13) 0.0019 0.0046 0.0046
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0019 0.0046 0.0774
Schistosoma mansoni hypothetical protein 0.0035 0.017 0.0373
Trypanosoma brucei C2 domain containing protein, putative 0.0019 0.0046 0.0224
Schistosoma mansoni synaptotagmin 0.0019 0.0046 0.0101
Plasmodium falciparum thioredoxin reductase 0.0034 0.0163 0.3637
Trypanosoma brucei transcription factor BTF3, putative 0.003 0.0131 0.0663
Mycobacterium tuberculosis Probable dehydrogenase 0.0078 0.0508 0.5225
Trypanosoma cruzi Coiled-coil and C2 domain-containing protein 0.0019 0.0046 0.0224
Echinococcus multilocularis neural cell expressed, developmentally 0.0019 0.0046 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0046 0.2551
Echinococcus multilocularis calpain 5 0.0019 0.0046 0.0046
Plasmodium falciparum perforin-like protein 5 0.0067 0.0424 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0083
Echinococcus granulosus multiple C2 and transmembrane domain containing protein 0.0019 0.0046 0.0101
Echinococcus multilocularis microtubule associated protein 2 0.0595 0.4569 0.4569
Leishmania major copine i-like protein 0.0019 0.0046 0.0224
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0055 0.0565
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0039 0.02 0.0439
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0123 0.0863 0.4438
Echinococcus multilocularis protein kinase c epsilon type 0.0019 0.0046 0.0046
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0046 0.0224
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0087 0.0576 0.5929
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0083
Trypanosoma cruzi transcription factor btf3, putative 0.003 0.0131 0.0663
Loa Loa (eye worm) hypothetical protein 0.0039 0.02 0.0381
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0025 0.0091 0.0148
Schistosoma mansoni cell adhesion molecule 0.0039 0.02 0.0439
Echinococcus multilocularis geminin 0.0123 0.0858 0.0858
Echinococcus multilocularis Niemann Pick C1 protein 0.0121 0.0848 0.0848
Trypanosoma brucei small ubiquitin-related modifier 0.0026 0.0102 0.0513
Brugia malayi Copine family protein 0.0019 0.0046 0.0073
Loa Loa (eye worm) hypothetical protein 0.0092 0.0619 0.1188
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0071 0.0455 0.0997
Trypanosoma brucei synaptotagmin, putative 0.0019 0.0046 0.0224
Plasmodium vivax perforin-like protein 2 0.0067 0.0424 1
Trypanosoma cruzi phosphoinositide-specific phospholipase C, putative 0.0019 0.0046 0.0224
Schistosoma mansoni copine 0.0019 0.0046 0.0101
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0046 0.2551
Mycobacterium tuberculosis Probable reductase 0.0078 0.0508 0.5225
Schistosoma mansoni hypothetical protein 0.0025 0.0091 0.0199
Loa Loa (eye worm) hypothetical protein 0.0039 0.02 0.0381
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0026 0.0096 0.0179
Echinococcus multilocularis expressed conserved protein 0.008 0.0521 0.0521
Brugia malayi C2 domain containing protein 0.0019 0.0046 0.0073
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0019 0.0046 0.0101
Trichomonas vaginalis copine, putative 0.0019 0.0046 0.2551
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.002 0.0055 0.0887
Loa Loa (eye worm) phosphatidylinositol-specific phospholipase C 0.0019 0.0046 0.0083
Brugia malayi C2 domain containing protein 0.0019 0.0046 0.0073
Trichomonas vaginalis splicing factor 3A subunit, putative 0.0019 0.0046 0.2551
Schistosoma mansoni hypothetical protein 0.0035 0.017 0.0373
Schistosoma mansoni voltage-gated potassium channel 0.0026 0.01 0.0219
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0039 0.02 0.02
Schistosoma mansoni synaptotagmin 12 0.0019 0.0046 0.0101
Loa Loa (eye worm) glutamate receptor 0.01 0.068 0.1305
Echinococcus granulosus roundabout 2 0.0039 0.02 0.0439
Trichomonas vaginalis Circumsporozoite protein precursor, putative 0.0019 0.0046 0.2551
Plasmodium falciparum small ubiquitin-related modifier 0.0026 0.0102 0.2145
Schistosoma mansoni fer-1-related 0.0019 0.0046 0.0101
Leishmania major 4-coumarate:coa ligase-like protein 0.002 0.0055 0.0269
Leishmania major acyl-CoA oxidase, putative 0.0092 0.0619 0.3183
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0046 0.0774
Schistosoma mansoni hypothetical protein 0.0019 0.0046 0.0101
Echinococcus granulosus Small ubiquitin modifier 2 0.0026 0.0102 0.0224
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0046 0.2551
Echinococcus multilocularis serine threonine protein kinase 0.0019 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0039 0.02 0.0381
Brugia malayi Niemann-Pick C1 protein precursor 0.0085 0.0561 0.094
Leishmania major hypothetical protein, conserved 0.0019 0.0046 0.0224
Plasmodium falciparum ferlin, putative 0.0019 0.0046 0.0774
Schistosoma mansoni hypothetical protein 0.0071 0.0455 0.0997
Brugia malayi Receptor family ligand binding region containing protein 0.0026 0.0096 0.0157
Trichomonas vaginalis synaptotagmin 1,2, putative 0.0019 0.0046 0.2551
Brugia malayi C2 domain containing protein 0.0019 0.0046 0.0073
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.0229 0.0229
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0046 0.2551
Loa Loa (eye worm) hypothetical protein 0.0026 0.0096 0.0179
Trichomonas vaginalis synaptotagmin, putative 0.0019 0.0046 0.2551
Echinococcus granulosus 1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4 0.0019 0.0046 0.0101
Schistosoma mansoni mctp-related 0.0019 0.0046 0.0101
Echinococcus multilocularis synaptotagmin 0.0019 0.0046 0.0046
Echinococcus granulosus microtubule associated protein 2 0.0595 0.4569 1
Echinococcus multilocularis multiple C2 and transmembrane domain containing protein 0.0019 0.0046 0.0046
Brugia malayi jmjC domain containing protein 0.0043 0.0229 0.038
Schistosoma mansoni hypothetical protein 0.0019 0.0046 0.0101
Loa Loa (eye worm) hypothetical protein 0.002 0.0055 0.0101
Schistosoma mansoni rabphilin-3a 0.0019 0.0046 0.0101
Schistosoma mansoni synaptotagmin 0.0019 0.0046 0.0101
Echinococcus multilocularis active breakpoint cluster region 0.0019 0.0046 0.0046
Brugia malayi WW domain containing protein 0.0019 0.0046 0.0073
Brugia malayi LD23056p 0.0019 0.0046 0.0073
Echinococcus multilocularis protein patched 0.0036 0.0181 0.0181
Schistosoma mansoni hypothetical protein 0.0016 0.0022 0.0048
Schistosoma mansoni hypothetical protein 0.0019 0.0046 0.0101
Brugia malayi Ubiquitin-like protein SMT3 0.0026 0.0102 0.0167
Plasmodium vivax perforin-like protein 1 0.0067 0.0424 1
Echinococcus granulosus expressed conserved protein 0.008 0.0521 0.114
Schistosoma mansoni synaptic ras gtpase activating protein syngap 0.0019 0.0046 0.0101
Brugia malayi C2 domain containing protein 0.0019 0.0046 0.0073
Echinococcus granulosus Niemann Pick C1 protein 0.0121 0.0848 0.1855
Echinococcus multilocularis sterol regulatory element binding protein 0.0036 0.0181 0.0181
Brugia malayi AMP-binding enzyme family protein 0.002 0.0055 0.0088
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0083
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0046 0.0224
Onchocerca volvulus 0.0019 0.0046 0.7307
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0046 0.0101
Schistosoma mansoni unc-13 (munc13) 0.0019 0.0046 0.0101
Trypanosoma brucei hypothetical protein, conserved 0.0019 0.0046 0.0224
Entamoeba histolytica transcription factor BTF3, putative 0.003 0.0131 0.1652
Leishmania major hypothetical protein, conserved 0.0019 0.0046 0.0224
Trypanosoma brucei C2 domain containing protein, putative 0.0019 0.0046 0.0224
Trichomonas vaginalis synaptotagmin 1,2, putative 0.0019 0.0046 0.2551
Loa Loa (eye worm) hypothetical protein 0.0015 0.0014 0.0022
Brugia malayi C2 domain containing protein 0.0019 0.0046 0.0073
Loa Loa (eye worm) hypothetical protein 0.0039 0.02 0.0381
Plasmodium falciparum perforin-like protein 4 0.0067 0.0424 1
Onchocerca volvulus 0.0019 0.0046 0.7307
Mycobacterium ulcerans hypothetical protein 0.0137 0.0972 1
Echinococcus granulosus defective proboscis extension response 0.0039 0.02 0.0439
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0046 0.2551
Echinococcus multilocularis transcription factor btf3 0.003 0.0131 0.0131
Echinococcus granulosus synaptotagmin 0.0019 0.0046 0.0101

Activities

Activity type Activity value Assay description Source Reference
RUmax (binding) = 0 % Binding affinity to human PrPC at 40 uM ChEMBL. 16420046
RUmax (binding) = 0 % Binding affinity to truncated human PrPC at 40 uM ChEMBL. 16420046
RUmax (binding) = 0 % Binding affinity to mouse PrPC at 40 uM ChEMBL. 16420046
RUmax (binding) = 0 % Binding affinity to human PrPC at 40 uM ChEMBL. 16420046
RUmax (binding) = 0 % Binding affinity to truncated human PrPC at 40 uM ChEMBL. 16420046
RUmax (binding) = 0 % Binding affinity to mouse PrPC at 40 uM ChEMBL. 16420046

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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