Detailed information for compound 35417

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 645.679 | Formula: C33H31N3O9S
  • H donors: 7 H acceptors: 8 LogP: 6.37 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 3
  • SMILES: COc1c2CCc3c(c2c(c2c1C(=O)c1c(C2=O)cc(c(c1O)C)O)O)c(O)c(c(c3)/C=N/NC(=S)NC1CCCCC1)C(=O)O
  • InChi: 1S/C33H31N3O9S/c1-13-19(37)11-18-23(26(13)38)30(42)25-24(27(18)39)29(41)22-17(31(25)45-2)9-8-14-10-15(21(32(43)44)28(40)20(14)22)12-34-36-33(46)35-16-6-4-3-5-7-16/h10-12,16,37-38,40-41H,3-9H2,1-2H3,(H,43,44)(H2,35,36,46)/b34-12+
  • InChiKey: FVWBMJCLBWIYFZ-PONZDJLKSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens steroid sulfatase (microsomal), isozyme S Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi hypothetical protein Get druggable targets OG5_130476 All targets in OG5_130476
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium ulcerans arylsulfatase AtsB steroid sulfatase (microsomal), isozyme S 583 aa 470 aa 23.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis CMGC family protein kinase 0.0147 0.0807 0.3062
Echinococcus multilocularis nervana 2 0.0142 0.0759 0.0875
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0452 0.3583 0.4278
Brugia malayi Immunoglobulin I-set domain containing protein 0.0064 0.0048 0.0017
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0128 0.0634 0.0725
Loa Loa (eye worm) hypothetical protein 0.0132 0.0671 0.0701
Loa Loa (eye worm) TK/FER protein kinase 0.0094 0.0322 0.0325
Brugia malayi hypothetical protein 0.0114 0.0502 0.0506
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0179 0.1099 1
Brugia malayi Tyrosine-protein kinase abl-1 0.0217 0.144 0.1517
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0179 0.1091 0.4169
Schistosoma mansoni growth factor receptor-bound protein 0.0087 0.0255 0.0486
Echinococcus multilocularis NCK adaptor protein 0.0087 0.0255 0.0268
Schistosoma mansoni nephrin 0.0139 0.0729 0.141
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0227 0.153 0.1804
Trichomonas vaginalis AGC family protein kinase 0.0225 0.151 0.58
Schistosoma mansoni serine/threonine protein kinase 0.0154 0.0871 0.1687
Schistosoma mansoni tyrosine kinase 0.0077 0.017 0.032
Trypanosoma brucei polo-like protein kinase 0.031 0.2287 0.8745
Loa Loa (eye worm) hypothetical protein 0.0102 0.0396 0.0404
Entamoeba histolytica PH domain containing protein kinase, putative 0.0138 0.0722 0.1779
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0115 0.0516 0.4693
Loa Loa (eye worm) hypothetical protein 0.0133 0.0677 0.0707
Schistosoma mansoni serine/threonine protein kinase 0.0154 0.0871 0.1687
Loa Loa (eye worm) TK/FER protein kinase 0.0094 0.0322 0.0325
Trypanosoma brucei casein kinase I, isoform 2 0.0124 0.0597 0.1725
Echinococcus granulosus fibroblast growth factor receptor 4 0.0269 0.1915 0.1876
Schistosoma mansoni serine/threonine protein kinase 0.0405 0.3148 0.6126
Brugia malayi Temporarily assigned gene name protein 59 0.0128 0.0634 0.0649
Schistosoma mansoni tyrosine kinase 0.025 0.1738 0.3377
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.0097 0.0346 0.0643
Entamoeba histolytica protein kinase, putative 0.0098 0.0361 0.0686
Echinococcus granulosus insulin receptor 0.0246 0.17 0.166
Loa Loa (eye worm) CAMK/PHK protein kinase 0.0188 0.1177 0.1245
Entamoeba histolytica protein kinase, putative 0.0167 0.0982 0.2567
Schistosoma mansoni cell adhesion molecule 0.0135 0.0693 0.134
Brugia malayi Immunoglobulin I-set domain containing protein 0.008 0.0197 0.0177
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0129 0.0643 0.2707
Brugia malayi P38 map kinase family protein 2 0.0182 0.1125 0.1177
Loa Loa (eye worm) hypothetical protein 0.0128 0.0634 0.0661
Loa Loa (eye worm) hypothetical protein 0.0289 0.2092 0.223
Onchocerca volvulus 0.0133 0.0677 0.1117
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.027 0.1919 0.188
Trichomonas vaginalis AGC family protein kinase 0.0093 0.0313 0.1142
Brugia malayi protein unc-22 0.008 0.0197 0.0177
Schistosoma mansoni growth factor receptor-bound protein 0.0084 0.0234 0.0445
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0289 0.2092 0.4068
Brugia malayi SRC-1 0.0227 0.153 0.1614
Leishmania major protein kinase A catalytic subunit 0.0129 0.0643 0.2189
Echinococcus granulosus tyrosine protein kinase Src42A 0.0156 0.0887 0.0843
Giardia lamblia Kinase, CMGC CK2 0.0115 0.0508 0.0909
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0289 0.2092 0.2054
Brugia malayi Variant SH3 domain containing protein 0.0063 0.0038 0.0006
Brugia malayi serine/threonine protein kinase 6 0.0167 0.0982 0.1024
Brugia malayi Protein kinase domain containing protein 0.023 0.156 0.1647
Loa Loa (eye worm) hypothetical protein 0.0133 0.0677 0.0707
Echinococcus multilocularis glycine receptor subunit beta 0.0289 0.2092 0.2481
Echinococcus granulosus CDC7 cell division cycle 7 0.0103 0.04 0.0354
Brugia malayi Protein kinase domain containing protein 0.063 0.5197 0.5567
Brugia malayi Variant SH3 domain containing protein 0.0084 0.0234 0.0217
Schistosoma mansoni serine/threonine protein kinase 0.0255 0.1785 0.3468
Echinococcus granulosus serine:threonine protein kinase 0.0131 0.0654 0.0609
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.014 0.0739 0.2647
Echinococcus multilocularis hypothetical protein 0.0117 0.0531 0.0601
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.0396 0.1465
Brugia malayi Protein kinase domain containing protein 0.0515 0.4151 0.4439
Schistosoma mansoni tyrosine kinase 0.0227 0.153 0.2972
Loa Loa (eye worm) hypothetical protein 0.0289 0.2092 0.223
Loa Loa (eye worm) AGC/NDR protein kinase 0.0192 0.1217 0.1288
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0133 0.0677 0.0777
Echinococcus multilocularis serine:threonine protein kinase 3 0.0295 0.2147 0.2547
Trichomonas vaginalis STE family protein kinase 0.0156 0.0885 0.3367
Schistosoma mansoni serine/threonine protein kinase 0.0192 0.1217 0.2362
Brugia malayi Tyrosine-protein kinase abl-1 0.0147 0.0805 0.0833
Onchocerca volvulus 0.0212 0.1397 0.2546
Loa Loa (eye worm) hypothetical protein 0.0155 0.0881 0.0926
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0095 0.033 0.0703
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0133 0.0677 0.0695
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0154 0.0869 0.1007
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0362 0.276 0.2725
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0216 0.1431 0.1518
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0128 0.0634 0.1225
Schistosoma mansoni protein kinase 0.0079 0.0182 0.0344
Schistosoma mansoni serine/threonine kinase 0.0249 0.173 0.3362
Loa Loa (eye worm) hypothetical protein 0.0155 0.0881 0.0926
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.014 0.0739 0.2315
Plasmodium vivax tyrosine kinase-like protein, putative 0.0093 0.0308 0.2806
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0176 0.1068 0.4591
Echinococcus multilocularis PAK box P21 Rho binding 0.0073 0.0134 0.0122
Schistosoma mansoni protein kinase 0.0498 0.3998 0.7785
Echinococcus multilocularis tyrosine protein kinase shark 0.0339 0.2555 0.3039
Brugia malayi Protein kinase domain containing protein 0.0405 0.3148 0.3358
Echinococcus multilocularis expressed conserved protein 0.0154 0.0869 0.1007
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0093 0.0313 0.0266
Echinococcus multilocularis growth factor receptor bound protein 2 0.0084 0.0234 0.0243
Loa Loa (eye worm) TK/FER protein kinase 0.0094 0.0322 0.0325
Brugia malayi Protein kinase domain 0.0098 0.0361 0.0354
Echinococcus granulosus casein kinase i 0.0124 0.0597 0.0552
Schistosoma mansoni serine/threonine protein kinase 0.0136 0.0704 0.136
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.0255 0.1785 0.1899
Schistosoma mansoni serine/threonine protein kinase 0.0159 0.0914 0.1771
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0133 0.0677 0.0632
Echinococcus multilocularis tyrosine protein kinase 0.0317 0.2349 0.2791
Echinococcus multilocularis insulin receptor 0.0246 0.17 0.2009
Schistosoma mansoni protein kinase 0.0175 0.1063 0.206
Echinococcus multilocularis casein kinase ii subunit alpha 0.0115 0.0508 0.0573
Schistosoma mansoni serine/threonine protein kinase 0.0129 0.0643 0.1242
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0213 0.1404 0.1478
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0147 0.0807 0.2682
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0201 0.1291 0.1249
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0147 0.0807 0.0846
Trichomonas vaginalis AGC family protein kinase 0.007 0.0099 0.0308
Schistosoma mansoni vam6/vps39 related 0.0128 0.0634 0.1225
Loa Loa (eye worm) TK/EGFR protein kinase 0.028 0.2017 0.2149
Echinococcus granulosus calcium dependent protein kinase 0.0078 0.0176 0.0128
Trichomonas vaginalis AGC family protein kinase 0.0216 0.1431 0.5492
Schistosoma mansoni serine/threonine protein kinase 0.0248 0.172 0.3342
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.0396 0.1465
Entamoeba histolytica PH domain containing protein kinase, putative 0.0188 0.1178 0.3158
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0147 0.0807 0.3433
Loa Loa (eye worm) hypothetical protein 0.0139 0.0728 0.0761
Trichomonas vaginalis STE family protein kinase 0.0073 0.0134 0.0444
Loa Loa (eye worm) TK/FER protein kinase 0.0094 0.0322 0.0325
Leishmania major protein kinase, putative 0.0167 0.0982 0.3802
Trichomonas vaginalis STE family protein kinase 0.0098 0.0361 0.1327
Echinococcus multilocularis roundabout 2 0.016 0.092 0.1069
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0087 0.0257 0.0997
Echinococcus multilocularis serine threonine protein kinase 0.0239 0.1645 0.1943
Schistosoma mansoni adapter molecule crk 0.0084 0.0234 0.0445
Trichomonas vaginalis CAMK family protein kinase 0.0145 0.0783 0.2969
Echinococcus granulosus cyclin dependent kinase 5 0.0136 0.0704 0.0659
Schistosoma mansoni cell adhesion molecule 0.0064 0.0048 0.0082
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.0232 0.158 0.1678
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0289 0.2092 0.222
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.0396 0.1465
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0062 0.0033 0.0013
Loa Loa (eye worm) LGC-31 protein 0.0289 0.2092 0.223
Trypanosoma cruzi casein kinase, putative 0.0124 0.0597 0.2505
Echinococcus granulosus tyrosine protein kinase Src64B 0.0227 0.153 0.1489
Echinococcus granulosus tyrosine protein kinase Lyn 0.0264 0.187 0.1831
Brugia malayi intracellular kinase 0.0147 0.0807 0.0834
Schistosoma mansoni nAChR subunit 0.0133 0.0677 0.1309
Entamoeba histolytica protein kinase, putative 0.0095 0.033 0.0594
Schistosoma mansoni neurotransmitter gated ion channel 0.0133 0.0677 0.1309
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0129 0.0643 0.1915
Onchocerca volvulus 0.0094 0.0322 0.0412
Loa Loa (eye worm) hypothetical protein 0.0155 0.0881 0.0926
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.007 0.0099 0.0308
Loa Loa (eye worm) CMGC/SRPK protein kinase 0.0095 0.033 0.0333
Loa Loa (eye worm) hypothetical protein 0.0133 0.0677 0.0707
Loa Loa (eye worm) hypothetical protein 0.0142 0.0757 0.0792
Echinococcus granulosus serine:threonine protein kinase PLK1 0.031 0.2287 0.225
Brugia malayi Protein kinase domain containing protein 0.0245 0.1691 0.1787
Echinococcus multilocularis casein kinase I alpha 0.0124 0.0597 0.068
Entamoeba histolytica PH domain containing protein kinase, putative 0.0138 0.0722 0.1779
Loa Loa (eye worm) TK protein kinase 0.0294 0.2142 0.2284
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0362 0.276 0.294
Schistosoma mansoni serine/threonine protein kinase 0.0192 0.1217 0.2362
Trichomonas vaginalis mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative 0.0062 0.0033 0.005
Schistosoma mansoni serine/threonine protein kinase 0.0303 0.2224 0.4326
Trypanosoma cruzi casein kinase, putative 0.0124 0.0597 0.2505
Brugia malayi Protein kinase domain containing protein 0.0689 0.5735 0.6146
Onchocerca volvulus 0.0289 0.2092 0.3928
Trichomonas vaginalis CAMK family protein kinase 0.0131 0.0654 0.247
Schistosoma mansoni serine/threonine protein kinase 0.0103 0.04 0.0768
Echinococcus granulosus protein kinase shaggy 0.0147 0.0807 0.0762
Schistosoma mansoni serine/threonine protein kinase 0.0129 0.0643 0.1242
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0155 0.0881 0.0914
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.04 0.1479
Echinococcus granulosus tyrosine protein kinase Fyn 0.0227 0.153 0.1489
Echinococcus multilocularis protein kinase c epsilon type 0.0242 0.1668 0.197
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0064 0.0048 0.0082
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0142 0.0759 0.0875
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0064 0.0048 0.0018
Echinococcus granulosus glycine receptor subunit alpha 1 0.0289 0.2092 0.2054
Loa Loa (eye worm) hypothetical protein 0.0133 0.0677 0.0707
Schistosoma mansoni nAChR subunit 0.0289 0.2092 0.4068
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0289 0.2092 0.2054
Loa Loa (eye worm) SRC-1 0.0227 0.153 0.1625
Echinococcus granulosus Protein kinase C brain isozyme 0.0288 0.2082 0.2044
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0269 0.1915 0.2268
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0195 0.1242 0.12
Brugia malayi casein kinase I 0.0124 0.0597 0.0609
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0098 0.0361 0.0314
Loa Loa (eye worm) hypothetical protein 0.0142 0.0757 0.0792
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.0097 0.0346 0.0643
Echinococcus granulosus phosphorylase kinase gamma subunit 0.0188 0.1177 0.1134
Echinococcus multilocularis epidermal growth factor receptor 0.028 0.2017 0.239
Loa Loa (eye worm) hypothetical protein 0.0133 0.0677 0.0707
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0115 0.0516 0.047
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0033 0.0052
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.0396 0.1465
Brugia malayi hypothetical protein 0.0133 0.0677 0.0695
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0195 0.1242 0.1457
Loa Loa (eye worm) camk/dcamkl protein kinase 0.0173 0.1038 0.1095
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0405 0.3148 0.3366
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0289 0.2092 0.222
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0129 0.0643 0.1915
Echinococcus granulosus tyrosine protein kinase Fyn 0.0227 0.153 0.1489
Brugia malayi Protein kinase domain containing protein 0.0689 0.5735 0.6146
Echinococcus multilocularis serine:threonine protein kinase 38 0.0192 0.1217 0.1427
Loa Loa (eye worm) hypothetical protein 0.0137 0.071 0.0742
Loa Loa (eye worm) TK protein kinase 0.0142 0.0762 0.0798
Schistosoma mansoni tyrosine kinase 0.0227 0.153 0.2972
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0289 0.2092 0.4068
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0129 0.0643 0.0598
Loa Loa (eye worm) hypothetical protein 0.0065 0.0056 0.0038
Entamoeba histolytica protein kinase, putative 0.0117 0.0529 0.1195
Schistosoma mansoni serine/threonine protein kinase 0.0548 0.4449 0.8663
Echinococcus multilocularis CDC7 cell division cycle 7 0.0103 0.04 0.0442
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0248 0.172 0.168
Entamoeba histolytica protein kinase, putative 0.0082 0.0213 0.0239
Entamoeba histolytica serine/threonine protein kinase, putative 0.0102 0.0396 0.0793
Loa Loa (eye worm) TK protein kinase 0.0317 0.2349 0.2507
Mycobacterium ulcerans hypothetical protein 0.0117 0.0529 0.5
Echinococcus granulosus tyrosine protein kinase 0.0317 0.2349 0.2312
Brugia malayi Protein kinase domain containing protein 0.0249 0.173 0.1829
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0101 0.0383 0.0391
Schistosoma mansoni protein kinase 0.0073 0.0134 0.0249
Loa Loa (eye worm) hypothetical protein 0.0289 0.2092 0.223
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0176 0.1068 0.4591
Brugia malayi hypothetical protein 0.0133 0.0677 0.0695
Loa Loa (eye worm) hypothetical protein 0.0133 0.0677 0.0707
Trichomonas vaginalis AGC family protein kinase 0.007 0.0099 0.0308
Schistosoma mansoni tyrosine kinase 0.0269 0.1915 0.3723
Loa Loa (eye worm) hypothetical protein 0.0164 0.0959 0.1011
Schistosoma mansoni neuroglian 0.0064 0.0048 0.0082
Echinococcus granulosus raf serine:threonine protein kinase 0.0089 0.028 0.0233
Echinococcus granulosus serine:threonine protein kinase TAO1 0.0255 0.1785 0.1745
Echinococcus granulosus serine:threonine kinase SAD 1 0.0102 0.0396 0.035
Schistosoma mansoni protein kinase 0.0221 0.1477 0.2869
Echinococcus granulosus calcium activated potassium channel 0.0154 0.0871 0.0827
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0093 0.0308 0.0542
Brugia malayi hypothetical protein 0.0094 0.0322 0.0312
Loa Loa (eye worm) hypothetical protein 0.0129 0.0643 0.067
Schistosoma mansoni tyrosine kinase 0.028 0.2017 0.3921
Loa Loa (eye worm) hypothetical protein 0.0155 0.0881 0.0926
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0289 0.2092 0.4068
Entamoeba histolytica protein kinase 2, putative 0.0179 0.1099 0.2919
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0136 0.0704 0.0735
Echinococcus granulosus Immunoglobulin 0.0096 0.0338 0.0292
Onchocerca volvulus 0.0147 0.0807 0.1374
Trichomonas vaginalis CMGC family protein kinase 0.0159 0.0914 0.3482
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.1082 0.931 1
Schistosoma mansoni tyrosine kinase 0.0246 0.17 0.3304
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0227 0.153 0.1804
Brugia malayi phosphoinositide-dependent protein kinase I 0.0093 0.0313 0.0302
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0115 0.0516 0.1432
Echinococcus granulosus cyclin dependent kinase 0.0136 0.0704 0.0659
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0166 0.0976 0.0932
Loa Loa (eye worm) CAMK protein kinase 0.008 0.0197 0.0189
Entamoeba histolytica casein kinase, putative 0.0115 0.0508 0.1132
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0289 0.2092 0.222
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.0361 0.0692
Trichomonas vaginalis CK1 family protein kinase 0.0124 0.0597 0.2248
Giardia lamblia Kinase, CMGC CDK 0.0136 0.0704 0.1907
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.031 0.2287 0.244
Trypanosoma brucei protein kinase, putative 0.0147 0.0807 0.2594
Echinococcus granulosus tyrosine protein kinase Srms 0.0563 0.4585 0.4559
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0133 0.0677 0.0695
Trichomonas vaginalis CK1 family protein kinase 0.0124 0.0597 0.2248
Entamoeba histolytica protein kinase domain containing protein 0.0079 0.0182 0.0146
Toxoplasma gondii histone kinase SNF1, putative 0.0102 0.0396 0.0919
Brugia malayi Kinase associated domain 1 family protein 0.0117 0.0531 0.0537
Plasmodium falciparum tyrosine kinase-like protein, putative 0.0093 0.0308 0.1376
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0166 0.0974 0.0931
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0227 0.153 0.1804
Loa Loa (eye worm) hypothetical protein 0.0155 0.0881 0.0926
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0289 0.2092 0.2481
Loa Loa (eye worm) hypothetical protein 0.0099 0.0364 0.0369
Brugia malayi Protein kinase domain containing protein 0.0094 0.0322 0.0312
Giardia lamblia Kinase, CMGC DYRK 0.0159 0.0914 0.2985
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0167 0.0982 0.2567
Echinococcus granulosus casein kinase I alpha 0.0124 0.0597 0.0552
Trichomonas vaginalis CAMK family protein kinase 0.031 0.2287 0.8824
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0335 0.251 0.268
Trichomonas vaginalis CAMK family protein kinase 0.0132 0.0665 0.251
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.014 0.0739 0.3135
Entamoeba histolytica hypothetical protein 0.0437 0.344 1
Loa Loa (eye worm) hypothetical protein 0.0289 0.2092 0.223
Brugia malayi Protein kinase domain containing protein 0.0124 0.0593 0.0604
Trichomonas vaginalis CMGC family protein kinase 0.0136 0.0704 0.2661
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0289 0.2092 0.2481
Brugia malayi hypothetical protein 0.0255 0.1785 0.1888
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0154 0.0869 0.1007
Loa Loa (eye worm) hypothetical protein 0.0114 0.0502 0.0518
Entamoeba histolytica protein kinase, putative 0.0081 0.0202 0.0206
Schistosoma mansoni serine/threonine protein kinase 0.0176 0.1068 0.207
Onchocerca volvulus 0.0094 0.0322 0.0412
Trichomonas vaginalis CMGC family protein kinase 0.0159 0.0914 0.3482
Giardia lamblia Kinase, CDC7 0.0103 0.04 0.0356
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0147 0.0807 0.0932
Brugia malayi protein-tyrosine kinase 0.0195 0.1242 0.1304
Brugia malayi Protein kinase domain containing protein 0.0093 0.0313 0.0302
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0136 0.0704 0.0735
Trichomonas vaginalis CMGC family protein kinase 0.0098 0.0361 0.1327
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0098 0.0361 0.0314
Onchocerca volvulus 0.0159 0.0917 0.1593
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.023 0.156 0.1658
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0129 0.0643 0.2707
Entamoeba histolytica protein kinase, putative 0.0093 0.0313 0.0542
Trypanosoma cruzi casein kinase II, putative 0.0115 0.0508 0.2109
Echinococcus granulosus NDR protein kinase 0.0192 0.1217 0.1175
Trichomonas vaginalis AGC family protein kinase 0.007 0.0099 0.0308
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0136 0.0704 0.2476
Brugia malayi Immunoglobulin I-set domain containing protein 0.0716 0.5985 0.6416
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0129 0.0643 0.0658
Loa Loa (eye worm) hypothetical protein 0.0208 0.1354 0.1436
Schistosoma mansoni serine/threonine protein kinase 0.0129 0.0643 0.1242
Entamoeba histolytica hypothetical protein 0.014 0.0739 0.1832
Brugia malayi SH2 domain containing protein 0.0094 0.0322 0.0312
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0021 0.0004
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0136 0.0704 0.0735
Echinococcus granulosus protein kinase c epsilon type 0.0242 0.1668 0.1628
Echinococcus granulosus c src tyrosine kinase 0.0126 0.0611 0.0565
Trypanosoma cruzi serine/arginine-rich protein specific kinase SRPK, putative 0.0095 0.033 0.132
Brugia malayi cell division control protein 2 homolog 0.0136 0.0704 0.0723
Schistosoma mansoni serine/threonine protein kinase 0.0242 0.1668 0.324
Loa Loa (eye worm) thyroid receptor interactor 0.0119 0.0548 0.0567
Loa Loa (eye worm) GABA receptor subunit 0.0155 0.0881 0.0926
Schistosoma mansoni protein kinase C mu 0.025 0.1737 0.3375
Entamoeba histolytica protein kinase, putative 0.0167 0.0982 0.2567
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0115 0.0516 0.0582
Brugia malayi Protein kinase domain containing protein 0.014 0.0739 0.0762
Brugia malayi Protein kinase domain containing protein 0.0094 0.0322 0.0312
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0115 0.0516 0.0533
Trichomonas vaginalis STE family protein kinase 0.0098 0.0361 0.1327
Schistosoma mansoni serine/threonine protein kinase 0.0248 0.172 0.3342
Echinococcus multilocularis titin 0.008 0.0197 0.0197
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0129 0.0643 0.198
Trypanosoma cruzi cdc2-related kinase 3 0.0136 0.0704 0.2975
Loa Loa (eye worm) AUR protein kinase 0.0167 0.0982 0.1035
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0289 0.2092 0.2054
Echinococcus granulosus serine threonine protein kinase nrc 0.0179 0.1099 0.1056
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0176 0.1068 0.3679
Loa Loa (eye worm) hypothetical protein 0.0164 0.0959 0.1011
Onchocerca volvulus 0.0155 0.0881 0.1521
Leishmania major protein kinase A catalytic subunit isoform 2 0.0129 0.0643 0.2189
Echinococcus multilocularis tyrosine protein kinase Abl 0.0217 0.144 0.1695
Echinococcus granulosus casein kinase I delta 0.0124 0.0597 0.0552
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0129 0.0643 0.2707
Brugia malayi serine/threonine-protein kinase plk-2 0.031 0.2287 0.243
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.0396 0.1465
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0098 0.0361 0.0848
Brugia malayi Immunoglobulin I-set domain containing protein 0.0064 0.0048 0.0017
Echinococcus multilocularis mitogen activated protein kinase 0.0098 0.0361 0.0395
Schistosoma mansoni protein kinase 0.0498 0.3998 0.7785
Loa Loa (eye worm) TK/ROR protein kinase 0.0066 0.0069 0.0052
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0081 0.0202 0.0204
Brugia malayi Protein kinase domain containing protein 0.0095 0.033 0.0321
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.0097 0.0346 0.0682
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0147 0.0807 0.2966
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0405 0.3148 0.3753
Schistosoma mansoni tyrosine kinase 0.0201 0.1291 0.2506
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0289 0.2092 0.222
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0213 0.1404 0.1362
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0266 0.1888 0.201
Brugia malayi Protein kinase domain containing protein 0.0176 0.1068 0.1116
Schistosoma mansoni serine/threonine protein kinase 0.0089 0.028 0.0533
Echinococcus multilocularis expressed protein 0.0095 0.033 0.0358
Brugia malayi putative serine/threonine kinase SADA gamma 0.0102 0.0396 0.0392
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0289 0.2092 0.222
Brugia malayi Immunoglobulin I-set domain containing protein 0.0064 0.0048 0.0017
Plasmodium vivax unspecified product 0.0115 0.0508 0.4623
Entamoeba histolytica protein kinase, putative 0.0081 0.0202 0.0206
Trichomonas vaginalis AGC family protein kinase 0.007 0.0099 0.0308
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0064 0.0048 0.0018
Loa Loa (eye worm) hypothetical protein 0.0289 0.2092 0.223
Loa Loa (eye worm) TK/EPH protein kinase 0.0135 0.0695 0.0726
Brugia malayi protein kinase C3,putative 0.0181 0.111 0.1161
Schistosoma mansoni hypothetical protein 0.0117 0.0531 0.1024
Brugia malayi hypothetical protein 0.0133 0.0677 0.0695
Loa Loa (eye worm) hypothetical protein 0.0133 0.0677 0.0707
Echinococcus multilocularis neuroglian 0.0064 0.0048 0.0018
Loa Loa (eye worm) hypothetical protein 0.0082 0.0217 0.0211
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0155 0.0881 0.1706
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0716 0.5985 0.642
Echinococcus granulosus cGMP dependent protein kinase 1 0.0154 0.0869 0.0825
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0443 0.3495 0.4171
Schistosoma mansoni serine/threonine protein kinase 0.0136 0.0704 0.136
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.0255 0.1785 0.2111
Schistosoma mansoni serine/threonine protein kinase 0.031 0.2287 0.4448
Echinococcus granulosus nAChR subunit 0.0289 0.2092 0.2054
Onchocerca volvulus 0.0558 0.4545 0.8801
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0175 0.1063 0.1122
Echinococcus granulosus glycine receptor subunit alpha 1 0.0289 0.2092 0.2054
Echinococcus multilocularis rho associated protein kinase 0.0373 0.2861 0.3408
Echinococcus multilocularis cyclin dependent kinase 0.0136 0.0704 0.0808
Loa Loa (eye worm) AGC/AKT protein kinase 0.0343 0.2589 0.2765
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.023 0.156 0.184
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0117 0.053 0.0484
Trypanosoma brucei cdc2-related kinase 1 0.0136 0.0704 0.2166
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.0232 0.158 0.1864
Loa Loa (eye worm) hypothetical protein 0.0103 0.0399 0.0408
Schistosoma mansoni serine/threonine protein kinase 0.014 0.0739 0.143
Trichomonas vaginalis AGC family protein kinase 0.0343 0.2589 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0115 0.0516 0.0582
Loa Loa (eye worm) hypothetical protein 0.0128 0.0634 0.0661
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0093 0.0313 0.0315
Trichomonas vaginalis AGC family protein kinase 0.007 0.0099 0.0308
Leishmania major protein kinase, putative 0.0176 0.1068 0.4207
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0289 0.2092 0.4068
Echinococcus granulosus homeodomain interacting protein kinase 3 0.0232 0.158 0.1539
Giardia lamblia Kinase, AGC PKA 0.0129 0.0643 0.1599
Loa Loa (eye worm) hypothetical protein 0.0289 0.2092 0.223
Loa Loa (eye worm) hypothetical protein 0.0114 0.0502 0.0518
Trichomonas vaginalis CAMK family protein kinase 0.031 0.2287 0.8824
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0452 0.3583 0.3552
Plasmodium vivax serine/threonine protein kinase, putative 0.0095 0.033 0.3005
Echinococcus multilocularis serine:threonine protein kinase N2 0.0192 0.1217 0.1427
Schistosoma mansoni serine/threonine protein kinase 0.0102 0.0396 0.0761
Entamoeba histolytica protein kinase domain containing protein 0.0115 0.0508 0.1132
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0115 0.0516 0.0582
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0136 0.0704 0.2239
Loa Loa (eye worm) hypothetical protein 0.0289 0.2092 0.223
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0115 0.0516 0.4693
Onchocerca volvulus Serine\/threonine kinase homolog 0.031 0.2287 0.4316
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0124 0.0597 0.0621
Echinococcus granulosus mitogen activated protein kinase 0.0098 0.0361 0.0314
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0084 0.0234 0.023
Schistosoma mansoni serine/threonine protein kinase 0.0188 0.1177 0.2283
Trichomonas vaginalis CMGC family protein kinase 0.0115 0.0508 0.19
Loa Loa (eye worm) hypothetical protein 0.0133 0.0677 0.0707
Schistosoma mansoni acetylcholine receptor subunit beta 0.0133 0.0677 0.1309
Trichomonas vaginalis CMGC family protein kinase 0.0098 0.0361 0.1327
Echinococcus granulosus NCK adaptor protein 0.0084 0.0234 0.0187
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0289 0.2092 0.2481
Giardia lamblia Kinase, PLK 0.031 0.2287 1
Loa Loa (eye worm) ACC-1 protein 0.0289 0.2092 0.223
Onchocerca volvulus 0.0221 0.1476 0.2703
Brugia malayi Protein kinase domain containing protein 0.0192 0.1217 0.1277
Schistosoma mansoni tyrosine kinase 0.0159 0.0915 0.1772
Loa Loa (eye worm) hypothetical protein 0.0096 0.0341 0.0345
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0201 0.1299 0.1376
Loa Loa (eye worm) hypothetical protein 0.0096 0.0338 0.0342
Schistosoma mansoni protein kinase 0.0098 0.0361 0.0691
Trichomonas vaginalis AGC family protein kinase 0.007 0.0099 0.0308
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0176 0.1068 0.3679
Schistosoma mansoni neurotransmitter gated ion channel 0.0133 0.0677 0.1309
Schistosoma mansoni titin 0.008 0.0197 0.0372
Schistosoma mansoni serine/threonine protein kinase 0.0245 0.1691 0.3285
Brugia malayi Protein kinase domain containing protein 0.0103 0.04 0.0396
Plasmodium vivax calcium-dependent protein kinase, putative 0.0115 0.0516 0.4693
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0383 0.2949 0.3143
Echinococcus multilocularis serine:threonine protein kinase 0.0131 0.0654 0.0749
Echinococcus granulosus nervana 2 0.0142 0.0759 0.0714
Entamoeba histolytica protein kinase, putative 0.009 0.0286 0.046
Schistosoma mansoni serine/threonine protein kinase 0.0373 0.2861 0.5567
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0289 0.2092 0.222
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.0159 0.0914 0.0962
Plasmodium falciparum NIMA related kinase 1 0.0156 0.0885 0.7664
Loa Loa (eye worm) hypothetical protein 0.0131 0.0654 0.0682
Schistosoma mansoni ste20-related kinase 0.0235 0.1606 0.312
Brugia malayi p70 ribosomal S6 kinase beta 0.0335 0.251 0.2671
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0084 0.0234 0.0229
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0115 0.0508 0.4623
Trypanosoma brucei Casein kinase II 0.0115 0.0508 0.1354
Leishmania major casein kinase II, putative 0.0115 0.0508 0.1548
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.0689 0.5735 0.6151
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.0159 0.0914 0.095
Loa Loa (eye worm) TK protein kinase 0.0195 0.1242 0.1315
Giardia lamblia Kinase, NEK 0.0156 0.0885 0.2834
Echinococcus granulosus epidermal growth factor receptor 0.028 0.2017 0.1978
Brugia malayi Immunoglobulin I-set domain containing protein 0.0294 0.2142 0.2274
Echinococcus granulosus serine:threonine protein kinase 0.0131 0.0654 0.0609
Schistosoma mansoni serine/threonine protein kinase 0.0102 0.0396 0.0761
Echinococcus granulosus STE20 serine:threonine protein kinase 0.0568 0.463 0.4605
Onchocerca volvulus 0.0289 0.2092 0.3928
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0129 0.0643 0.0735
Loa Loa (eye worm) hypothetical protein 0.0352 0.2668 0.285
Brugia malayi Protein kinase c protein 2 0.0132 0.0671 0.0688
Schistosoma mansoni neurotransmitter gated ion channel 0.0155 0.0881 0.1706
Plasmodium vivax protein kinase Crk2 0.0136 0.0704 0.6401
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0289 0.2097 0.2235
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.0396 0.1465
Echinococcus granulosus protein kinase c iota type 0.0336 0.2521 0.2485
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0227 0.153 0.1489
Echinococcus granulosus serine:threonine protein kinase N2 0.0149 0.0822 0.0777
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0396 0.3073 0.3286
Echinococcus granulosus activin receptor type 0.0079 0.0182 0.0135
Entamoeba histolytica p21-activated kinase 0.0107 0.044 0.0925
Schistosoma mansoni serine/threonine protein kinase 0.0167 0.0982 0.1904
Schistosoma mansoni cell adhesion molecule 0.0064 0.0048 0.0082
Echinococcus multilocularis raf serine:threonine protein kinase 0.0089 0.028 0.0297
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0405 0.3148 0.3366
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0124 0.0597 0.2505
Loa Loa (eye worm) TK/FAK protein kinase 0.063 0.5197 0.5573
Echinococcus granulosus serine:threonine protein kinase N2 0.0341 0.2573 0.2537
Loa Loa (eye worm) hypothetical protein 0.0289 0.2092 0.223
Echinococcus multilocularis Immunoglobulin 0.0096 0.0338 0.0368
Echinococcus multilocularis glycine receptor subunit beta 0.0289 0.2092 0.2481
Loa Loa (eye worm) hypothetical protein 0.0074 0.0135 0.0123
Loa Loa (eye worm) AGC/PKA protein kinase 0.0129 0.0643 0.067
Echinococcus multilocularis cyclin dependent kinase 1 0.0136 0.0704 0.0808
Onchocerca volvulus 0.0094 0.0322 0.0412
Brugia malayi Doublecortin family protein 0.0173 0.1038 0.1084
Loa Loa (eye worm) acetylcholine receptor protein 0.0133 0.0677 0.0707
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0188 0.1178 0.508
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0115 0.0516 0.0521
Loa Loa (eye worm) hypothetical protein 0.0133 0.0677 0.0707
Brugia malayi hypothetical protein 0.0347 0.2625 0.2795
Echinococcus multilocularis neuroglian 0.0121 0.0565 0.0641
Loa Loa (eye worm) TK/FER protein kinase 0.0094 0.0322 0.0325
Trichomonas vaginalis CMGC family protein kinase 0.0159 0.0914 0.3482
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0128 0.0634 0.0589
Plasmodium falciparum calcium-dependent protein kinase 4 0.0115 0.0516 0.3638
Echinococcus multilocularis protein tyrosine kinase 0.0623 0.5134 0.6147
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0129 0.0643 0.0598
Schistosoma mansoni serine/threonine kinase 0.0192 0.1217 0.2362
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.031 0.2287 0.2717
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0264 0.1864 0.2206
Leishmania major protein kinase, putative 0.0176 0.1068 0.4207
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0159 0.0914 0.3042
Echinococcus granulosus tyrosine protein kinase ABL1 0.0332 0.2491 0.2455
Loa Loa (eye worm) hypothetical protein 0.0084 0.0234 0.023
Entamoeba histolytica protein kinase domain containing protein 0.0167 0.0982 0.2567
Brugia malayi hypothetical protein 0.0065 0.0056 0.0025
Giardia lamblia Kinase, CMGC GSK 0.0147 0.0807 0.2435
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.007 0.0099 0.0308
Echinococcus granulosus dual specificity 0.014 0.0739 0.0695
Echinococcus multilocularis Glutaredoxin protein 5 0.0142 0.0759 0.0875
Schistosoma mansoni nephrin 0.0064 0.0048 0.0082
Trypanosoma cruzi casein kinase, putative 0.0124 0.0597 0.2505
Entamoeba histolytica casein kinase 1, putative 0.0124 0.0597 0.1402
Echinococcus granulosus titin 0.008 0.0197 0.0149
Echinococcus granulosus protein kinase 0.0175 0.1063 0.1019
Schistosoma mansoni vav2 0.011 0.0463 0.089
Brugia malayi probable protein kinase 0.0304 0.2231 0.2369
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0129 0.0643 0.1915
Brugia malayi ephrin receptor 1 precursor 0.0076 0.0158 0.0135
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0096 0.0338 0.0648
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0249 0.173 0.184
Loa Loa (eye worm) AGC/PKG protein kinase 0.0154 0.0869 0.0913
Loa Loa (eye worm) CAMK/PKD protein kinase 0.025 0.1737 0.1847
Trichomonas vaginalis AGC family protein kinase 0.007 0.0099 0.0308
Brugia malayi hypothetical protein 0.0128 0.0634 0.0649
Schistosoma mansoni serine/threonine protein kinase 0.0289 0.2097 0.4077
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0167 0.0982 0.2567
Brugia malayi Cation transporter family protein 0.0289 0.2092 0.222
Schistosoma mansoni serine/threonine protein kinase 0.0081 0.0202 0.0382
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0289 0.2092 0.223
Entamoeba histolytica protein kinase, putative 0.0082 0.0213 0.0239
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0084 0.0234 0.0445
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0179 0.1099 0.1285
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0155 0.0881 0.1706
Giardia lamblia Kinase, NEK 0.0156 0.0885 0.2834
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0192 0.1217 0.1427
Echinococcus multilocularis ephrin type A receptor 4 A 0.0115 0.0512 0.0577
Loa Loa (eye worm) hypothetical protein 0.0103 0.0399 0.0408
Trichomonas vaginalis AGC family protein kinase 0.0093 0.0313 0.1142
Entamoeba histolytica SH2-protein kinase domain containing protein 0.009 0.0286 0.046
Schistosoma mansoni tyrosine kinase 0.028 0.2011 0.3909
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0213 0.1404 0.1489
Entamoeba histolytica protein kinase, putative 0.0343 0.2589 0.7427
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0179 0.1099 0.4729
Echinococcus multilocularis calcium activated potassium channel 0.0154 0.0871 0.101
Trichomonas vaginalis CAMK family protein kinase 0.031 0.2287 0.8824
Schistosoma mansoni tyrosine kinase 0.0246 0.17 0.3304
Trypanosoma brucei rac serine-threonine kinase, putative 0.0343 0.2589 1
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.0396 0.1465
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0098 0.0361 0.0314
Brugia malayi hypothetical protein 0.0133 0.0677 0.0695
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0064 0.0048 0.0029
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0133 0.0677 0.0632
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0098 0.0361 0.0767
Echinococcus granulosus nAChR subunit 0.0155 0.0881 0.0837
Brugia malayi Protein kinase domain containing protein 0.0421 0.3296 0.3518
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0062 0.0033 0.0013
Leishmania major protein kinase A catalytic subunit isoform 1 0.0129 0.0643 0.2189
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0167 0.0982 0.894
Echinococcus multilocularis myosin iiia 0.0097 0.0346 0.0378
Giardia lamblia Kinase, CMGC GSK 0.0147 0.0807 0.2435
Loa Loa (eye worm) hypothetical protein 0.0212 0.1397 0.1481
Plasmodium falciparum casein kinase 1 0.0124 0.0597 0.4529
Schistosoma mansoni nAChR subunit 0.0289 0.2092 0.4068
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0101 0.0388 0.0395
Loa Loa (eye worm) hypothetical protein 0.0133 0.0677 0.0707
Echinococcus granulosus dual specificity 0.0159 0.0914 0.0871
Brugia malayi hypothetical protein 0.0133 0.0677 0.0695
Plasmodium falciparum glycogen synthase kinase 3 0.0147 0.0807 0.6812
Loa Loa (eye worm) hypothetical protein 0.0401 0.3118 0.3335
Trichomonas vaginalis CMGC family protein kinase 0.0115 0.0508 0.19
Schistosoma mansoni serine/threonine protein kinase 0.0124 0.0597 0.1153
Echinococcus granulosus aurora kinase A 0.0167 0.0982 0.0939
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0362 0.276 0.2949
Onchocerca volvulus 0.008 0.0197 0.0162
Trypanosoma cruzi polo-like protein kinase, putative 0.031 0.2287 1
Schistosoma mansoni protein kinase 0.0421 0.3296 0.6415
Echinococcus granulosus expressed protein 0.0095 0.033 0.0284
Echinococcus granulosus dual specificity 0.0159 0.0914 0.0871
Trichomonas vaginalis CMGC family protein kinase 0.0115 0.0508 0.19
Echinococcus granulosus twitchin 0.0158 0.0905 0.0861
Echinococcus granulosus dual specificity 0.0159 0.0914 0.0871
Trichomonas vaginalis CMGC family protein kinase 0.0159 0.0914 0.3482
Plasmodium vivax serine/threonine kinase-1, putative 0.0176 0.1068 0.9716
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0096 0.0338 0.0368
Loa Loa (eye worm) hypothetical protein 0.0133 0.0677 0.0707
Loa Loa (eye worm) CDC7 protein kinase 0.0103 0.04 0.0408
Trichomonas vaginalis AGC family protein kinase 0.0156 0.0885 0.3367
Echinococcus granulosus Glutaredoxin protein 5 0.0142 0.0759 0.0714
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0115 0.0508 0.0525
Brugia malayi Protein kinase domain containing protein 0.0071 0.0108 0.0081
Trypanosoma cruzi casein kinase, putative 0.0124 0.0597 0.2505
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0289 0.2092 0.222
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0115 0.0516 0.047
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0115 0.0516 0.1432
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0101 0.0383 0.0337
Plasmodium falciparum calcium-dependent protein kinase 2 0.0115 0.0516 0.3638
Schistosoma mansoni tyrosine kinase 0.0126 0.0611 0.1179
Loa Loa (eye worm) hypothetical protein 0.0133 0.0677 0.0707
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0102 0.0396 0.1612
Trypanosoma cruzi cdc2-related kinase 1 0.0136 0.0704 0.2975
Brugia malayi serine/threonine-protein kinase PAK 7 0.0266 0.1888 0.2
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0257 0.1808 0.1768
Brugia malayi Homeodomain interacting protein kinase protein 1 0.0232 0.158 0.1668
Trichomonas vaginalis CMGC family protein kinase 0.0136 0.0704 0.2661
Echinococcus multilocularis epidermal growth factor receptor 0.0201 0.1291 0.1516
Trypanosoma brucei aurora B kinase 0.0167 0.0982 0.3325
Brugia malayi Variant SH3 domain containing protein 0.0084 0.0234 0.0217
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.033 0.0632
Echinococcus multilocularis N chimaerin 0.0101 0.0383 0.0422
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0289 0.2092 0.222
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0289 0.2092 0.222
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0115 0.0516 0.1432
Brugia malayi MAP kinase sur-1 0.0098 0.0361 0.0354
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0155 0.0881 0.0914
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0166 0.0974 0.1134
Echinococcus multilocularis tyrosine protein kinase Srms 0.0195 0.1242 0.1457
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0182 0.1125 0.4479
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.0396 0.1465
Plasmodium falciparum protein serine/threonine kinase-1 0.0176 0.1068 0.9659
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0289 0.2092 0.223
Schistosoma mansoni protein kinase 0.0257 0.1808 0.3514
Loa Loa (eye worm) hypothetical protein 0.0133 0.0677 0.0707
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0033 0.0052
Echinococcus granulosus neuroglian 0.0121 0.0565 0.052
Entamoeba histolytica protein kinase , putative 0.0167 0.0982 0.2567
Onchocerca volvulus 0.0094 0.0322 0.0412
Echinococcus multilocularis serine:threonine protein kinase 0.0131 0.0654 0.0749
Echinococcus granulosus serine:threonine protein kinase 3 0.0295 0.2147 0.2109
Schistosoma mansoni protein kinase 0.0304 0.2231 0.4338
Brugia malayi serine/threonine-protein kinase 6 0.0167 0.0982 0.1024
Schistosoma mansoni serine/threonine protein kinase 0.0176 0.1068 0.207
Brugia malayi Hr1 repeat family protein 0.0341 0.2573 0.2738
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0279 0.2005 0.2377
Trichomonas vaginalis CAMK family protein kinase 0.031 0.2287 0.8824
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0421 0.3296 0.3264
Echinococcus multilocularis serine:threonine protein kinase N2 0.0149 0.0822 0.0951
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.031 0.2287 1
Loa Loa (eye worm) hypothetical protein 0.0221 0.1476 0.1566
Giardia lamblia Kinase, CK1 Casein kinase 0.0124 0.0597 0.1365
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0126 0.0611 0.1179
Echinococcus multilocularis calcium dependent protein kinase 0.0078 0.0176 0.0172
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0063 0.0038 0.0019
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.0396 0.1465
Echinococcus granulosus mitogen activated protein kinase 11 0.0182 0.1125 0.1082
Schistosoma mansoni tyrosine kinase 0.0201 0.1291 0.2506
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0227 0.153 0.1804
Brugia malayi Casein kinase II, alpha chain 0.0115 0.0508 0.0512
Entamoeba histolytica casein kinase, putative 0.0124 0.0597 0.1402
Echinococcus granulosus casein kinase I alpha 0.0124 0.0597 0.0552
Trichomonas vaginalis CMGC family protein kinase 0.0115 0.0508 0.19
Entamoeba histolytica protein kinase domain containing protein 0.014 0.0739 0.1832
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0097 0.0346 0.1392
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0176 0.1068 0.1127
Entamoeba histolytica cell division protein kinase 2, putative 0.0136 0.0704 0.1723
Onchocerca volvulus 0.0094 0.0322 0.0412
Echinococcus multilocularis nervana 2 0.0142 0.0759 0.0875
Onchocerca volvulus 0.0289 0.2092 0.3928
Loa Loa (eye worm) TK/FER protein kinase 0.0094 0.0322 0.0325
Loa Loa (eye worm) hypothetical protein 0.0289 0.2092 0.223
Schistosoma mansoni serine/threonine protein kinase 0.0293 0.2128 0.4137
Echinococcus multilocularis casein kinase I alpha 0.0124 0.0597 0.068
Brugia malayi Fes/CIP4 homology domain containing protein 0.0119 0.0548 0.0555
Echinococcus multilocularis death associated protein kinase 1 0.0974 0.8332 1
Echinococcus multilocularis maternal embryonic leucine zipper kinase 0.0132 0.0665 0.0761
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0179 0.1099 1
Schistosoma mansoni hypothetical protein 0.0117 0.0531 0.1024
Toxoplasma gondii casein kinase I 0.0124 0.0597 0.1784
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0128 0.0634 0.1878
Loa Loa (eye worm) hypothetical protein 0.0064 0.0048 0.0029
Trichomonas vaginalis STE family protein kinase 0.0097 0.0346 0.1272
Brugia malayi protein kinase C II. 0.0242 0.1668 0.1762
Loa Loa (eye worm) hypothetical protein 0.0065 0.0056 0.0038
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0332 0.2491 0.2962
Trypanosoma cruzi Protein kinase B 0.0188 0.1178 0.508
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0098 0.0361 0.0395
Echinococcus granulosus casein kinase I alpha 0.0124 0.0597 0.0552
Echinococcus multilocularis serine:threonine protein kinase N2 0.0341 0.2573 0.3061
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0227 0.153 0.1489
Onchocerca volvulus 0.0164 0.0959 0.1677
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0156 0.0887 0.1029
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0405 0.3148 0.3358
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0289 0.2092 0.2054
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0128 0.0634 0.2669
Trichomonas vaginalis AGC family protein kinase 0.0167 0.0982 0.3747
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0128 0.0634 0.2669
Brugia malayi Cation transporter family protein 0.0289 0.2092 0.222
Trichomonas vaginalis CAMK family protein kinase 0.031 0.2287 0.8824
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0136 0.0704 0.0659
Echinococcus multilocularis aurora kinase A 0.0167 0.0982 0.1144
Echinococcus multilocularis cyclin dependent kinase 5 0.0136 0.0704 0.0808
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.0159 0.0914 0.3478
Onchocerca volvulus 0.0133 0.0677 0.1117
Trichomonas vaginalis CMGC family protein kinase 0.0147 0.0807 0.3062
Entamoeba histolytica protein kinase domain containing protein 0.0147 0.0807 0.2035
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0098 0.0361 0.1455
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0289 0.2092 0.4068
Schistosoma mansoni serine/threonine protein kinase 0.0232 0.158 0.3069
Echinococcus granulosus roundabout 2 0.016 0.092 0.0877
Trichomonas vaginalis AGC family protein kinase 0.0167 0.0982 0.3747
Schistosoma mansoni protein kinase 0.0115 0.0508 0.0979
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0133 0.0677 0.0695
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0227 0.153 0.1804
Plasmodium vivax glycogen synthase kinase 3, putative 0.0147 0.0807 0.734
Brugia malayi Temporarily assigned gene name protein 59 0.0148 0.0815 0.0843
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0129 0.0643 0.0598
Echinococcus multilocularis 0.0073 0.0131 0.0119
Schistosoma mansoni serine/threonine protein kinase 0.0154 0.0869 0.1682
Echinococcus granulosus epidermal growth factor receptor 0.0201 0.1291 0.1249
Echinococcus multilocularis protein kinase c iota type 0.0336 0.2521 0.2999
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0129 0.0643 0.0735
Plasmodium falciparum serine/threonine protein kinase, putative 0.0167 0.0982 0.8729
Echinococcus granulosus ephrin type A receptor 4 A 0.0115 0.0512 0.0466
Giardia lamblia Kinase, AGC PKA 0.0179 0.1099 0.3928
Echinococcus granulosus dual specificity protein kinase clk2 0.0176 0.1068 0.1025
Loa Loa (eye worm) STE/STE20/SLK protein kinase 0.0221 0.1477 0.1568
Echinococcus multilocularis STE20 serine:threonine protein kinase 0.0568 0.463 0.554
Loa Loa (eye worm) hypothetical protein 0.0155 0.0881 0.0926
Onchocerca volvulus 0.0155 0.0881 0.1521
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0147 0.0807 0.0846
Giardia lamblia Kinase, STE STE20 0.0098 0.0361 0.0155
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0147 0.0807 0.0762
Echinococcus multilocularis 0.0139 0.0728 0.0837
Loa Loa (eye worm) hypothetical protein 0.0289 0.2092 0.223
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0129 0.0643 0.0735
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative 0.0102 0.0396 0.1016
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0155 0.0881 0.0914
Giardia lamblia Aurora kinase 0.0167 0.0982 0.3333
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0289 0.2092 0.4068
Onchocerca volvulus 0.0289 0.2092 0.3928
Plasmodium falciparum casein kinase 2, alpha subunit 0.0115 0.0508 0.3554
Entamoeba histolytica protein kinase, putative 0.0115 0.0516 0.1155
Trichomonas vaginalis AGC family protein kinase 0.0216 0.1431 0.5492
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0134 0.0685 0.0704
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.0516 0.193
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0227 0.153 0.1804
Echinococcus granulosus casein kinase I delta 0.0124 0.0597 0.0552
Echinococcus granulosus cyclin dependent kinase 1 0.0136 0.0704 0.0659
Trypanosoma cruzi cdc2-related kinase 1 0.0136 0.0704 0.2975
Loa Loa (eye worm) hypothetical protein 0.0689 0.5735 0.6151
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0182 0.1125 0.3917
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0143 0.0764 0.2766
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0289 0.2092 0.222
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0101 0.0383 0.0736
Brugia malayi Protein kinase domain containing protein 0.0222 0.1487 0.1568
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0288 0.2082 0.247
Echinococcus multilocularis nAChR subunit 0.0289 0.2092 0.2481
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0066 0.0069 0.0021
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.0159 0.0914 0.3145
Trichomonas vaginalis AGC family protein kinase 0.007 0.0099 0.0308
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0362 0.276 0.2725
Echinococcus multilocularis activin receptor type 0.0079 0.0182 0.018
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0093 0.0313 0.0338
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0133 0.0677 0.0707
Echinococcus multilocularis dual specificity 0.014 0.0739 0.0851
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0498 0.3998 0.4778
Echinococcus multilocularis nAChR subunit 0.0155 0.0881 0.1022
Echinococcus granulosus mitogen activated protein kinase 14 0.0182 0.1125 0.1082
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.014 0.0739 0.3135
Schistosoma mansoni serine/threonine protein kinase 0.0154 0.0871 0.1687
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0176 0.1068 0.3804
Echinococcus granulosus tyrosine protein kinase HCK 0.0142 0.0762 0.0717
Brugia malayi Protein kinase domain containing protein 0.0246 0.17 0.1797
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0213 0.1404 0.1652
Schistosoma mansoni atypical protein kinase C 0.0343 0.2585 0.5029
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0267 0.1891 0.1852
Schistosoma mansoni nAChR subunit 0.0289 0.2092 0.4068
Onchocerca volvulus 0.0103 0.04 0.0565
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0092 0.0303 0.0256
Entamoeba histolytica hypothetical protein 0.0155 0.0881 0.2259
Onchocerca volvulus 0.0103 0.04 0.0565
Brugia malayi serine/threonine kinase 12 0.0167 0.0982 0.1024
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0098 0.0361 0.0395
Schistosoma mansoni serine/threonine protein kinase 0.0288 0.2082 0.4049
Plasmodium falciparum calcium-dependent protein kinase 3 0.0115 0.0516 0.3638
Schistosoma mansoni nAChR subunit 0.0289 0.2092 0.4068
Echinococcus multilocularis tyrosine protein kinase Blk 0.0195 0.1242 0.1457
Trichomonas vaginalis CMGC family protein kinase 0.0115 0.0508 0.19
Entamoeba histolytica protein kinase, putative 0.0095 0.033 0.0594
Echinococcus granulosus tyrosine kinase 0.0195 0.1242 0.12
Loa Loa (eye worm) TK/INSR protein kinase 0.0246 0.17 0.1808
Trichomonas vaginalis CMGC family protein kinase 0.0159 0.0914 0.3482
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.0396 0.1465
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0167 0.0982 0.1144
Trypanosoma cruzi polo-like protein kinase, putative 0.031 0.2287 1
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0248 0.172 0.2033
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0079 0.0182 0.0663
Loa Loa (eye worm) hypothetical protein 0.0155 0.0881 0.0926
Echinococcus multilocularis roundabout 2 0.0064 0.0048 0.0018
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0289 0.2092 0.222
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0443 0.3495 0.3463
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0129 0.0643 0.5027
Loa Loa (eye worm) hypothetical protein 0.0159 0.0917 0.0965
Schistosoma mansoni serine/threonine protein kinase 0.0288 0.2082 0.4049
Trichomonas vaginalis CK1 family protein kinase 0.0124 0.0597 0.2248
Trichomonas vaginalis AGC family protein kinase 0.0167 0.0982 0.3747
Trichomonas vaginalis CMGC family protein kinase 0.0115 0.0508 0.19
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0136 0.0704 0.2476
Trichomonas vaginalis CMGC family protein kinase 0.0115 0.0508 0.19
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0133 0.0677 0.0695
Schistosoma mansoni ephrin receptor 0.0115 0.0512 0.0986
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0102 0.0396 0.0888
Brugia malayi Immunoglobulin I-set domain containing protein 0.0114 0.0502 0.0506
Onchocerca volvulus 0.0074 0.0135 0.004
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0289 0.2092 0.2481
Brugia malayi Protein kinase domain containing protein 0.1082 0.931 1
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0227 0.153 0.1804
Entamoeba histolytica protein kinase domain containing protein 0.0147 0.0807 0.2035
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0295 0.2147 0.2289
Echinococcus granulosus maternal embryonic leucine zipper kinase 0.0132 0.0665 0.062
Loa Loa (eye worm) hypothetical protein 0.0267 0.1891 0.2013
Echinococcus granulosus serine/threonine protein kinase 0.0188 0.1178 0.1136
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0279 0.2005 0.1967
Echinococcus multilocularis protein kinase shaggy 0.0147 0.0807 0.0932
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0133 0.0677 0.0695
Entamoeba histolytica protein kinase domain containing protein 0.0159 0.0914 0.2361
Brugia malayi excitatory GABA receptor EXP-1A 0.0289 0.2092 0.222
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.008 0.0197 0.0189
Trichomonas vaginalis AGC family protein kinase 0.007 0.0099 0.0308
Trypanosoma cruzi cdc2-related kinase 3 0.0136 0.0704 0.2975
Brugia malayi casein kinase 1, delta 0.0124 0.0597 0.0609
Schistosoma mansoni serine/threonine protein kinase 0.0102 0.0396 0.0761
Schistosoma mansoni serine/threonine protein kinase 0.0102 0.0396 0.0761
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0289 0.2097 0.2487
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0498 0.3998 0.3969
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0084 0.0234 0.023
Trichomonas vaginalis AGC family protein kinase 0.0129 0.0643 0.2426
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0257 0.1808 0.2139
Loa Loa (eye worm) hypothetical protein 0.0155 0.0881 0.0926
Schistosoma mansoni serine/threonine protein kinase 0.0213 0.1404 0.2726
Brugia malayi RhoGAP domain containing protein 0.0101 0.0383 0.0378
Brugia malayi C1-like domain containing protein 0.025 0.1737 0.1837
Brugia malayi Protein kinase domain containing protein 0.0216 0.1431 0.1507
Echinococcus granulosus casein kinase I gamma 0.0245 0.1691 0.1651
Loa Loa (eye worm) hypothetical protein 0.0362 0.276 0.2949
Schistosoma mansoni serine/threonine protein kinase 0.0109 0.0458 0.0882
Schistosoma mansoni serine/threonine-protein kinase 0.0188 0.1178 0.2285
Trypanosoma cruzi casein kinase, putative 0.0124 0.0597 0.2505
Loa Loa (eye worm) hypothetical protein 0.0061 0.0025 0.0005
Echinococcus granulosus cGMP dependent protein kinase 1 0.0154 0.0869 0.0825
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0362 0.276 0.2725
Trichomonas vaginalis AGC family protein kinase 0.0093 0.0313 0.1142
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0421 0.3296 0.3932
Onchocerca volvulus Putative nachr subunit 0.0362 0.276 0.5256
Onchocerca volvulus 0.0336 0.2521 0.478
Giardia lamblia Kinase, AGC AKT 0.0134 0.0685 0.1815
Leishmania major protein kinase, putative 0.0115 0.0516 0.1584
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0264 0.1864 0.1825
Loa Loa (eye worm) hypothetical protein 0.0133 0.0677 0.0707
Echinococcus multilocularis Immunoglobulin 0.0096 0.0338 0.0368
Brugia malayi Variant SH3 domain containing protein 0.0101 0.0383 0.0378
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0289 0.2092 0.2481
Schistosoma mansoni tyrosine kinase 0.0339 0.2555 0.497
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0289 0.2092 0.222
Trichomonas vaginalis AGC family protein kinase 0.0167 0.0982 0.3747
Schistosoma mansoni tyrosine kinase 0.0623 0.5134 1
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0452 0.3583 0.3835
Schistosoma mansoni kinase 0.0331 0.248 0.4824
Schistosoma mansoni protein kinase 0.0098 0.0361 0.0691
Onchocerca volvulus 0.0124 0.0597 0.0958
Schistosoma mansoni protein kinase 0.0257 0.1808 0.3514
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0098 0.0361 0.0848
Schistosoma mansoni acetylcholine receptor-related 0.0133 0.0677 0.1309
Echinococcus multilocularis mitogen activated protein kinase 14 0.0182 0.1125 0.1316
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0289 0.2092 0.2481
Trichomonas vaginalis CAMK family protein kinase 0.031 0.2287 0.8824
Schistosoma mansoni nAChR subunit 0.0133 0.0677 0.1309
Brugia malayi Stress-activated protein kinase jnk-1 0.0303 0.2224 0.2362
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.027 0.1919 0.2272
Echinococcus multilocularis dual specificity 0.0159 0.0914 0.1062
Echinococcus granulosus N chimaerin 0.0101 0.0383 0.0337
Echinococcus multilocularis dual specificity 0.0159 0.0914 0.1062
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0227 0.153 0.1804
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.0396 0.1465
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0188 0.1174 0.1241
Entamoeba histolytica protein kinase, putative 0.0335 0.251 0.7188
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0362 0.276 0.3287
Echinococcus multilocularis mitogen activated protein kinase 11 0.0182 0.1125 0.1316
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0182 0.1125 0.1189
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0289 0.2092 0.223
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0192 0.1217 0.1175
Brugia malayi Protein kinase domain containing protein 0.0317 0.2349 0.2497
Echinococcus granulosus tyrosine protein kinase Src42A 0.0227 0.153 0.1489
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0421 0.3296 0.3526
Brugia malayi STE20-like kinase MST 0.0295 0.2147 0.2279
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0289 0.2092 0.223
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0156 0.0885 0.3018
Toxoplasma gondii cell-cycle-associated protein kinase SRPK, putative 0.0095 0.033 0.0636
Loa Loa (eye worm) hypothetical protein 0.0289 0.2092 0.223
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0102 0.0396 0.3604
Schistosoma mansoni tyrosine kinase 0.0159 0.0915 0.1772
Echinococcus multilocularis casein kinase i 0.0124 0.0597 0.068
Leishmania major protein kinase, putative 0.0097 0.0346 0.078
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0129 0.0643 0.2707
Schistosoma mansoni tyrosine kinase 0.0126 0.0611 0.1179
Entamoeba histolytica serine/threonine protein kinase, putative 0.031 0.2287 0.6513
Loa Loa (eye worm) hypothetical protein 0.0096 0.0338 0.0342
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0102 0.0396 0.0404
Echinococcus granulosus growth factor receptor bound protein 2 0.0087 0.0255 0.0208
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0101 0.0383 0.0736
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0098 0.0361 0.1455
Trichomonas vaginalis AGC family protein kinase 0.0192 0.1217 0.466
Loa Loa (eye worm) TK/FER protein kinase 0.0094 0.0322 0.0325
Echinococcus granulosus glycine receptor subunit beta 0.0289 0.2092 0.2054
Brugia malayi Protein kinase domain containing protein 0.0094 0.0322 0.0312
Onchocerca volvulus 0.0087 0.0257 0.0283
Onchocerca volvulus Tyrosine kinase homolog 0.0624 0.5148 1
Toxoplasma gondii AGC kinase 0.0129 0.0643 0.198
Entamoeba histolytica protein kinase, putative 0.0343 0.2589 0.7427
Echinococcus multilocularis phosphorylase kinase gamma subunit 0.0188 0.1177 0.1379
Echinococcus granulosus tyrosine protein kinase Blk 0.0195 0.1242 0.12
Loa Loa (eye worm) hypothetical protein 0.0133 0.0677 0.0707
Entamoeba histolytica PH domain containing protein kinase, putative 0.0188 0.1178 0.3158
Echinococcus multilocularis casein kinase I gamma 0.0245 0.1691 0.1998
Brugia malayi Protein kinase domain containing protein 0.0188 0.1177 0.1233
Echinococcus multilocularis cyclin dependent kinase 1 0.0136 0.0704 0.0808
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0093 0.0313 0.0315
Plasmodium falciparum calcium-dependent protein kinase 1 0.0115 0.0516 0.3638
Plasmodium falciparum serine/threonine protein kinase KIN 0.0102 0.0396 0.2333
Echinococcus multilocularis c src tyrosine kinase 0.0126 0.0611 0.0696
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0192 0.1217 0.1175
Entamoeba histolytica protein kinase, putative 0.0147 0.0807 0.2035
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0133 0.0677 0.0777
Giardia lamblia Kinase, CMGC CDK 0.0136 0.0704 0.1907
Trichomonas vaginalis AGC family protein kinase 0.007 0.0099 0.0308
Schistosoma mansoni tyrosine kinase 0.0087 0.0261 0.0496
Trichomonas vaginalis AGC family protein kinase 0.0343 0.2589 1
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0115 0.0516 0.1385
Brugia malayi Protein kinase domain containing protein 0.0131 0.0654 0.067
Loa Loa (eye worm) hypothetical protein 0.0155 0.0881 0.0926
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0182 0.1125 0.4845
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.04 0.1479
Loa Loa (eye worm) hypothetical protein 0.0289 0.2092 0.223
Schistosoma mansoni rap gtpase-activating protein 0.0128 0.0634 0.1225
Echinococcus granulosus protein tyrosine kinase 0.0623 0.5134 0.5111
Trichomonas vaginalis CAMK family protein kinase 0.031 0.2287 0.8824
Loa Loa (eye worm) hypothetical protein 0.0289 0.2092 0.223
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.0396 0.1465
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.0515 0.4151 0.4446
Giardia lamblia Kinase, CMGC CLK 0.0176 0.1068 0.3769
Trichomonas vaginalis STE family protein kinase 0.0098 0.0361 0.1327
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0303 0.2224 0.2641
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0269 0.1915 0.2268
Schistosoma mansoni serine/threonine protein kinase 0.023 0.156 0.3031
Loa Loa (eye worm) hypothetical protein 0.0117 0.0531 0.055
Schistosoma mansoni serine/threonine protein kinase 0.008 0.0197 0.0372
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0081 0.0202 0.0155
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.023 0.156 0.1519
Trypanosoma cruzi aurora B kinase, putative 0.0167 0.0982 0.4213
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0159 0.0914 0.3911
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0176 0.1068 0.4591
Schistosoma mansoni hypothetical protein 0.0128 0.0634 0.1225
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0269 0.1915 0.1876
Loa Loa (eye worm) hypothetical protein 0.0128 0.0634 0.0661
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0289 0.2092 0.222
Giardia lamblia Kinase, NEK 0.0156 0.0885 0.2834
Brugia malayi Serine/threonine-protein kinase SULU 0.0255 0.1785 0.1888
Loa Loa (eye worm) TK/FER protein kinase 0.0443 0.3495 0.374
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0154 0.0869 0.2948
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0167 0.0982 0.2567
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0097 0.0346 0.1392
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0167 0.0982 0.0939
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0133 0.0677 0.0707
Schistosoma mansoni protein kinase 0.0498 0.3998 0.7785
Brugia malayi Fibronectin type III domain containing protein 0.0114 0.0502 0.0506
Echinococcus multilocularis mitogen activated protein kinase 3 0.0098 0.0361 0.0395
Onchocerca volvulus Serine\/threonine kinase homolog 0.0188 0.1177 0.211
Schistosoma mansoni tyrosine kinase 0.0287 0.2075 0.4034
Trichomonas vaginalis AGC family protein kinase 0.007 0.0099 0.0308
Loa Loa (eye worm) hypothetical protein 0.0117 0.053 0.0548
Echinococcus granulosus Vam6:Vps39 protein 0.0128 0.0634 0.0589
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0289 0.2092 0.222
Echinococcus multilocularis casein kinase I alpha 0.0124 0.0597 0.068
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0102 0.0396 0.1612
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0098 0.0361 0.1455
Entamoeba histolytica protein kinase, putative 0.0142 0.0762 0.19
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0131 0.0654 0.0682
Echinococcus multilocularis casein kinase I delta 0.0124 0.0597 0.068
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.014 0.0739 0.0774
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0405 0.3148 0.6025
Schistosoma mansoni serine/threonine protein kinase 0.027 0.1919 0.3729
Echinococcus multilocularis tyrosine protein kinase HCK 0.0142 0.0762 0.0879
Loa Loa (eye worm) AUR protein kinase 0.0167 0.0982 0.1035
Schistosoma mansoni protein kinase 0.0167 0.0982 0.1904
Giardia lamblia Kinase, CAMK CAMKL 0.0102 0.0396 0.0337
Trichomonas vaginalis AGC family protein kinase 0.007 0.0099 0.0308
Loa Loa (eye worm) hypothetical protein 0.0094 0.0318 0.032
Schistosoma mansoni serine/threonine protein kinase 0.0341 0.2573 0.5005
Leishmania major casein kinase, putative 0.0124 0.0597 0.1972
Schistosoma mansoni serine/threonine protein kinase 0.0452 0.3583 0.6975
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0115 0.0516 0.4693
Trichomonas vaginalis CAMK family protein kinase 0.0132 0.0665 0.251
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0362 0.276 0.3287
Onchocerca volvulus 0.0128 0.0634 0.1031
Echinococcus multilocularis 0.0175 0.1063 0.1241
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0124 0.0597 0.0621
Echinococcus multilocularis rac serine:threonine kinase 0.0188 0.1178 0.138
Entamoeba histolytica protein kinase, putative 0.014 0.0739 0.1832
Onchocerca volvulus 0.0289 0.2092 0.3928
Loa Loa (eye worm) hypothetical protein 0.0276 0.1973 0.2102
Loa Loa (eye worm) hypothetical protein 0.0159 0.0917 0.0965
Loa Loa (eye worm) hypothetical protein 0.053 0.4291 0.4596
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.0396 0.1465
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0129 0.0643 0.0735
Entamoeba histolytica protein kinase, putative 0.014 0.0739 0.1832
Schistosoma mansoni nAChR subunit 0.0289 0.2092 0.4068
Trypanosoma brucei protein kinase, putative 0.0098 0.0361 0.0742
Trichomonas vaginalis CAMK family protein kinase 0.0145 0.0783 0.2969
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0092 0.0303 0.0326
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0303 0.2224 0.2372
Trichomonas vaginalis CAMK family protein kinase 0.0249 0.173 0.6656
Giardia lamblia Kinase, STE STE20 0.0097 0.0346 0.0083
Echinococcus multilocularis tyrosine kinase 0.0094 0.0322 0.0349
Brugia malayi Egg laying defective protein 4 0.0154 0.0869 0.0901
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0383 0.2949 0.3152
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0155 0.0881 0.0914
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0242 0.1668 0.1773
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0033 0.0052
Brugia malayi Protein kinase domain containing protein 0.0136 0.0704 0.0723
Giardia lamblia Kinase, CAMK CAMKL 0.0102 0.0396 0.0337
Loa Loa (eye worm) hypothetical protein 0.0289 0.2092 0.223
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0179 0.1099 0.1056
Echinococcus granulosus glycine receptor subunit beta 0.0289 0.2092 0.2054
Trichomonas vaginalis AGC family protein kinase 0.0343 0.2589 1
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0128 0.0634 0.1225
Trichomonas vaginalis STE family protein kinase 0.0098 0.0361 0.1327
Schistosoma mansoni nAChR subunit 0.0289 0.2092 0.4068
Plasmodium falciparum cGMP-dependent protein kinase 0.0154 0.0869 0.7487
Plasmodium falciparum protein kinase 5 0.0136 0.0704 0.5686
Echinococcus granulosus cGMP dependent protein kinase 0.0154 0.0869 0.0825
Schistosoma mansoni serine/threonine protein kinase 0.0154 0.0869 0.1682
Brugia malayi Protein kinase domain containing protein 0.0221 0.1477 0.1557
Echinococcus granulosus mitogen activated protein kinase 3 0.0098 0.0361 0.0314
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative 0.0102 0.0396 0.1016
Loa Loa (eye worm) TK/ABL protein kinase 0.0332 0.2491 0.2659
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0098 0.0361 0.0395
Echinococcus granulosus defective proboscis extension response 0.0096 0.0338 0.0292
Trichomonas vaginalis CMGC family protein kinase 0.0176 0.1068 0.4078
Echinococcus multilocularis dual specificity protein kinase clk2 0.0176 0.1068 0.1247
Echinococcus multilocularis dual specificity 0.0159 0.0914 0.1062
Schistosoma mansoni nck2/grb4 0.0084 0.0234 0.0445
Toxoplasma gondii AGC kinase 0.0129 0.0643 0.198
Loa Loa (eye worm) TK/FER protein kinase 0.0094 0.0322 0.0325
Trypanosoma brucei cdc2-related kinase 3 0.0136 0.0704 0.2166
Trichomonas vaginalis AGC family protein kinase 0.0343 0.2589 1
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0362 0.276 0.3287
Echinococcus granulosus titin 0.008 0.0197 0.0149
Echinococcus granulosus tyrosine protein kinase Fyn 0.0227 0.153 0.1489
Echinococcus granulosus hypothetical protein 0.0139 0.0728 0.0683
Loa Loa (eye worm) protein kinase domain-containing protein 0.0245 0.1691 0.1798
Brugia malayi Furin-like cysteine rich region family protein 0.028 0.2017 0.2138
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0133 0.0677 0.0695
Echinococcus granulosus c-Jun N-terminal kinases 0.0303 0.2224 0.2187
Entamoeba histolytica protein kinase, putative 0.0159 0.0914 0.2361
Echinococcus multilocularis roundabout 2 0.0064 0.0048 0.0018
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0142 0.0759 0.0714
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0129 0.0643 0.5852
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0066 0.0069 0.0044
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.04 0.1479
Schistosoma mansoni serine/threonine protein kinase 0.0115 0.0516 0.0994
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0064 0.0048 0.0018
Brugia malayi Cation transporter family protein 0.0289 0.2092 0.222
Trichomonas vaginalis CMGC family protein kinase 0.0159 0.0914 0.3482
Onchocerca volvulus 0.0373 0.2861 0.5455
Loa Loa (eye worm) hypothetical protein 0.0115 0.0516 0.0533
Loa Loa (eye worm) hypothetical protein 0.0289 0.2092 0.223
Brugia malayi SH2 domain containing protein 0.0443 0.3495 0.3732
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0098 0.0361 0.1455
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0248 0.172 0.2033
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0176 0.1068 0.4591
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.0689 0.5735 0.6151
Loa Loa (eye worm) hypothetical protein 0.0159 0.0917 0.0965
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0182 0.1125 0.4845
Onchocerca volvulus 0.0094 0.0322 0.0412
Trichomonas vaginalis AGC family protein kinase 0.0343 0.2589 1
Schistosoma mansoni nAChR subunit 0.0289 0.2092 0.4068
Echinococcus granulosus tyrosine protein kinase shark 0.0339 0.2555 0.2519
Echinococcus granulosus rho-associated protein kinase 1 0.0373 0.2861 0.2826
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0064 0.0048 0.0018
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0405 0.3148 0.3115
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0289 0.2092 0.223
Plasmodium falciparum calcium-dependent protein kinase 5 0.0115 0.0516 0.3638
Schistosoma mansoni protein kinase 0.0124 0.0597 0.1153
Echinococcus multilocularis casein kinase I delta 0.0124 0.0597 0.068
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0115 0.0516 0.047
Trichomonas vaginalis CMGC family protein kinase 0.0136 0.0704 0.2661
Brugia malayi Protein kinase domain containing protein 0.0094 0.0322 0.0312
Echinococcus granulosus glycine receptor subunit alpha 1 0.0289 0.2092 0.2054
Plasmodium vivax casein kinase 1, putative 0.0124 0.0597 0.5436
Echinococcus granulosus casein kinase ii subunit alpha 0.0115 0.0508 0.0462
Trichomonas vaginalis AGC family protein kinase 0.007 0.0099 0.0308
Trichomonas vaginalis AGC family protein kinase 0.0343 0.2589 1
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0147 0.0807 0.1561
Brugia malayi Protein kinase domain containing protein 0.0343 0.2589 0.2756
Brugia malayi Cam kinase protein 1 0.0115 0.0516 0.0521
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0192 0.1217 0.1427
Echinococcus granulosus tyrosine kinase 0.0094 0.0322 0.0276
Schistosoma mansoni tyrosine kinase 0.0159 0.0915 0.1772
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0289 0.2092 0.222
Echinococcus multilocularis mitogen activated protein kinase 14 0.0182 0.1125 0.1316
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.0313 0.0599
Loa Loa (eye worm) AUR protein kinase 0.0167 0.0982 0.1035
Entamoeba histolytica protein kinase, putative 0.0192 0.1217 0.3277
Echinococcus multilocularis mitogen activated protein kinase 11 0.0182 0.1125 0.1316
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0115 0.0516 0.0533
Trypanosoma brucei SNF1-related protein kinases, putative 0.0102 0.0396 0.0888
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0096 0.0338 0.0648
Echinococcus granulosus nervana 2 0.0142 0.0759 0.0714
Trichomonas vaginalis AGC family protein kinase 0.0343 0.2589 1
Loa Loa (eye worm) TK protein kinase 0.039 0.3015 0.3223
Entamoeba histolytica protein kinase domain containing protein 0.0232 0.158 0.4374
Loa Loa (eye worm) hypothetical protein 0.0289 0.2092 0.223
Trichomonas vaginalis AGC family protein kinase 0.007 0.0099 0.0308
Toxoplasma gondii aurora kinase 0.0167 0.0982 0.3437
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0098 0.0361 0.0366
Loa Loa (eye worm) TK/FER protein kinase 0.0094 0.0322 0.0325
Toxoplasma gondii CMGC kinase, CK2 family 0.0115 0.0508 0.14
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0102 0.0396 0.0438
Brugia malayi map kinase activated protein kinase protein 2 0.0452 0.3583 0.3827
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0289 0.2097 0.2059
Echinococcus granulosus protein kinase C gamma type 0.0239 0.1645 0.1605
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0156 0.0885 0.8051
Trichomonas vaginalis CMGC family protein kinase 0.0098 0.0361 0.1327
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.0396 0.1465
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0094 0.0322 0.057
Entamoeba histolytica cell division protein kinase 2, putative 0.0136 0.0704 0.1723
Schistosoma mansoni serine/threonine protein kinase 0.027 0.1919 0.3729
Toxoplasma gondii AGC kinase 0.0335 0.251 1
Onchocerca volvulus 0.0289 0.2092 0.3928
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0124 0.0597 0.0621
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0101 0.0383 0.0422
Loa Loa (eye worm) AGC/PKA protein kinase 0.0129 0.0643 0.067
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0289 0.2092 0.2481
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0081 0.0202 0.0155
Loa Loa (eye worm) casein kinase 0.0207 0.1351 0.1432
Loa Loa (eye worm) hypothetical protein 0.0289 0.2092 0.223
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.025 0.1737 0.1837
Brugia malayi Protein kinase domain containing protein 0.0094 0.0322 0.0312
Brugia malayi Sex muscle abnormal protein 5 0.0084 0.0234 0.0217
Plasmodium falciparum serine/threonine protein kinase 0.0095 0.033 0.1614
Trichomonas vaginalis CMGC family protein kinase 0.0098 0.0361 0.1327
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.0396 0.1465
Onchocerca volvulus 0.0133 0.0677 0.1117
Loa Loa (eye worm) hypothetical protein 0.0147 0.0803 0.0843
Loa Loa (eye worm) hypothetical protein 0.0401 0.3118 0.3335
Loa Loa (eye worm) ACC-1 protein 0.0289 0.2092 0.223
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0098 0.0361 0.0742
Loa Loa (eye worm) hypothetical protein 0.0094 0.0322 0.0325
Loa Loa (eye worm) AGC/PKN protein kinase 0.0341 0.2573 0.2747
Trichomonas vaginalis AGC family protein kinase 0.007 0.0099 0.0308
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0227 0.153 0.1804
Giardia lamblia Kinase, CMGC MAPK 0.0098 0.0361 0.0156
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0166 0.0976 0.1136
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.0396 0.1465
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0081 0.0202 0.0204
Schistosoma mansoni vesicular amine transporter 0.0096 0.0338 0.0648
Trypanosoma brucei serine/arginine-rich protein specific kinase SRPK, putative 0.0095 0.033 0.0615
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.0396 0.1465
Trichomonas vaginalis AGC family protein kinase 0.007 0.0099 0.0308
Loa Loa (eye worm) hypothetical protein 0.0114 0.0502 0.0518
Loa Loa (eye worm) hypothetical protein 0.0289 0.2092 0.223
Schistosoma mansoni serine/threonine-protein kinase 0.0188 0.1178 0.2285
Trichomonas vaginalis AGC family protein kinase 0.007 0.0099 0.0308
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0079 0.0182 0.0663
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0133 0.0677 0.0777
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0289 0.2092 0.2054
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0248 0.172 0.168

Activities

Activity type Activity value Assay description Source Reference
Activity (ADMET) > 50 mg kg-1 Acute toxicity in chick embryo after 72 to 96 hrs by hen's fertile egg screening test ChEMBL. 17580843
IC50 (functional) > 50 ug ml-1 Growth inhibition of K562 cells ChEMBL. 17580843
IC50 (functional) > 50 ug ml-1 Growth inhibition of HeLa cells ChEMBL. 17580843
IC50 (functional) > 50 ug ml-1 Growth inhibition of K562 cells ChEMBL. 17580843
IC50 (functional) > 50 ug ml-1 Growth inhibition of HeLa cells ChEMBL. 17580843
IC50 (binding) = 0.46 uM Inhibitory activity againist Estrone sulfatase from MCF-7 cells (placental microsomes) ChEMBL. 11992772
IC50 (binding) = 0.46 uM Inhibition of Estrone sulfatase in human placental microsome ChEMBL. 17580843
IC50 (binding) = 0.46 uM Inhibitory activity againist Estrone sulfatase from MCF-7 cells (placental microsomes) ChEMBL. 11992772
IC50 (binding) = 0.46 uM Inhibition of Estrone sulfatase in human placental microsome ChEMBL. 17580843
Km (binding) = 27 uM Activity of Estrone sulfatase in human placental microsome ChEMBL. 17580843
Km (binding) = 27 uM Activity of Estrone sulfatase in human placental microsome ChEMBL. 17580843
LD50 (ADMET) > 50 mg kg-1 Acute toxicity of the compound in the hens fertile egg screening test (HEST). ChEMBL. 11992772

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.