Detailed information for compound 408094

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1170.31 | Formula: C58H79N11O15
  • H donors: 13 H acceptors: 15 LogP: -0.42 Rotable bonds: 41
    Rule of 5 violations (Lipinski): 4
  • SMILES: OC(=O)C[C@@H](C(=O)N[C@H](C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1ccccc1)C)Cc1ccccc1)C(C)C)NC(=O)[C@H]([C@H](O)C)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc1ccccc1)N)C
  • InChi: 1S/C58H79N11O15/c1-31(2)46(67-53(78)41(29-45(72)73)64-57(82)48(35(7)70)68-50(75)34(6)62-56(81)47(32(3)4)66-51(76)39(59)26-36-18-11-8-12-19-36)55(80)60-30-44(71)69-25-17-24-43(69)54(79)63-40(27-37-20-13-9-14-21-37)52(77)61-33(5)49(74)65-42(58(83)84)28-38-22-15-10-16-23-38/h8-16,18-23,31-35,39-43,46-48,70H,17,24-30,59H2,1-7H3,(H,60,80)(H,61,77)(H,62,81)(H,63,79)(H,64,82)(H,65,74)(H,66,76)(H,67,78)(H,68,75)(H,72,73)(H,83,84)/t33-,34-,35+,39-,40-,41-,42-,43-,46-,47-,48-/m0/s1
  • InChiKey: WMTZDAHGKCEIAT-ILJNECBNSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens receptor (G protein-coupled) activity modifying protein 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0029 0.0081 0.0075
Echinococcus multilocularis protein patched 0.0084 0.0379 0.0373
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.0143 0.093
Echinococcus granulosus phd:f box containing protein 0.0017 0.0015 0.0009
Schistosoma mansoni opsin-like receptor 0.0019 0.0026 0.002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.002
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0012 0.0084
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.002
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0161 0.0804 0.0799
Echinococcus granulosus 7TM GPCR rhodopsin 0.0019 0.0026 0.002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.002
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0095 0.0442 0.0436
Onchocerca volvulus 0.006 0.0252 0.0852
Brugia malayi nuclear hormone receptor family member odr-7 0.0045 0.0167 0.0161
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0047 0.0589
Brugia malayi Thioredoxin reductase 0.0048 0.0184 0.0178
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0026 0.002
Brugia malayi neuropeptide F receptor 0.0019 0.0026 0.002
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0989 0.5338 0.5336
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0095 0.0442 0.0436
Brugia malayi tailless protein 0.0045 0.0167 0.0161
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.002
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0062 0.0262 0.1848
Loa Loa (eye worm) TYRA-2 protein 0.0019 0.0026 0.002
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0019 0.0026 0.002
Schistosoma mansoni hypothetical protein 0.0022 0.0039 0.0034
Onchocerca volvulus 0.0019 0.0026 0.0031
Echinococcus granulosus epidermal growth factor receptor 0.184 1 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0102 0.0394
Toxoplasma gondii thioredoxin reductase 0.0048 0.0184 0.2548
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0113 0.1404
Echinococcus granulosus orexin receptor type 2 0.0019 0.0026 0.002
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0017 0.0015 0.0131
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0095 0.0442 0.0436
Schistosoma mansoni jumonji/arid domain-containing protein 0.0068 0.0293 0.0288
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0013 0.0007
Echinococcus multilocularis Niemann Pick C1 protein 0.0278 0.1445 0.144
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0143 0.1006
Echinococcus granulosus neuropeptide FF receptor 2 0.0019 0.0026 0.002
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0041 0.0143 0.1006
Brugia malayi Death domain containing protein 0.0016 0.0007 0.0001
Loa Loa (eye worm) hypothetical protein 0.0035 0.0113 0.0107
Schistosoma mansoni hypothetical protein 0.0019 0.0026 0.002
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0015 0.0009
Echinococcus granulosus fmrfamide receptor 0.0019 0.0026 0.002
Loa Loa (eye worm) DR-78 0.0045 0.0167 0.0161
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0062 0.0262 0.326
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0035 0.0113 0.0107
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0019 0.0026 0.002
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0015 0.0009
Brugia malayi Pre-SET motif family protein 0.0213 0.1087 0.1082
Onchocerca volvulus 0.0242 0.1248 0.4455
Mycobacterium ulcerans beta-lactamase 0.0072 0.0317 0.2218
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0012 0.0084
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0095 0.0442 0.0436
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0047 0.0042
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0095 0.0089
Mycobacterium tuberculosis Conserved protein 0.0072 0.0317 0.1272
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0095 0.0442 0.0436
Loa Loa (eye worm) neuropeptide F receptor 0.0019 0.0026 0.002
Schistosoma mansoni biogenic amine receptor 0.0019 0.0026 0.002
Schistosoma mansoni nuclear receptor nhr-48 0.0045 0.0167 0.0161
Brugia malayi nuclear hormone receptor family member nhr-6 0.0045 0.0167 0.0161
Schistosoma mansoni neuropeptide receptor 0.0019 0.0026 0.002
Echinococcus granulosus Ankyrin 0.0016 0.0008 0.0002
Loa Loa (eye worm) hypothetical protein 0.0045 0.0167 0.0161
Schistosoma mansoni nuclear hormone receptor 0.0045 0.0167 0.0161
Echinococcus granulosus somatostatin receptor 0.0019 0.0026 0.002
Loa Loa (eye worm) hypothetical protein 0.0045 0.0167 0.0161
Echinococcus multilocularis serotonin receptor 0.0019 0.0026 0.002
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.0059 0.041
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.006 0.0422
Loa Loa (eye worm) histone methyltransferase 0.002 0.0033 0.0027
Schistosoma mansoni hypothetical protein 0.0034 0.011 0.0104
Schistosoma mansoni hypothetical protein 0.0592 0.3166 0.3162
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0178 0.1225
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0012 0.0026
Echinococcus granulosus Smad4 0.0017 0.0013 0.0007
Schistosoma mansoni loxhd1 0.0022 0.0039 0.0034
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.002
Loa Loa (eye worm) hypothetical protein 0.0045 0.0167 0.0161
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0095 0.0442 0.0436
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0095 0.0442 0.0436
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0095 0.0442 0.0436
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.011 0.0521 0.2108
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0015 0.0009
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0178 0.1252
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.0009
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0143 0.0706 0.4934
Trypanosoma cruzi lanosterol synthase, putative 0.0031 0.0088 0.062
Brugia malayi Cytochrome P450 family protein 0.0057 0.0235 0.0229
Echinococcus multilocularis neuropeptides capa receptor 0.0019 0.0026 0.002
Schistosoma mansoni tyrosine kinase 0.0017 0.0012 0.0006
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0045 0.0167 0.0161
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.002
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0015 0.0009
Onchocerca volvulus 0.0019 0.0026 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0095 0.0442 0.0436
Toxoplasma gondii RNA-directed DNA polymerase 0.0084 0.0383 0.5393
Echinococcus granulosus alpha 1A adrenergic receptor 0.0019 0.0026 0.002
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0161 0.0804 0.0799
Echinococcus multilocularis orexin receptor type 2 0.0019 0.0026 0.002
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0184 0.229
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0042 0.015 0.0144
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0317 0.0311
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0113 0.1271
Echinococcus multilocularis sex peptide receptor 0.0019 0.0026 0.002
Schistosoma mansoni tyrosine kinase 0.184 1 1
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0047 0.0042
Echinococcus granulosus lysine specific demethylase 5A 0.0068 0.0293 0.0288
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0062 0.0262 0.1048
Loa Loa (eye worm) hypothetical protein 0.0032 0.0095 0.0089
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0039 0.0034
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0184 0.1297
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.0009
Entamoeba histolytica acetyltransferase, GNAT family 0.0131 0.064 0.4328
Trypanosoma cruzi PAB1-binding protein , putative 0.0078 0.0349 0.2458
Echinococcus multilocularis somatostatin receptor 0.0019 0.0026 0.002
Echinococcus multilocularis neuropeptide receptor 0.0019 0.0026 0.002
Loa Loa (eye worm) hypothetical protein 0.0115 0.0552 0.0546
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0178 0.0172
Brugia malayi mbt repeat family protein 0.0103 0.0482 0.0477
Echinococcus granulosus tm gpcr rhodopsin 0.0537 0.2862 0.2857
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.0273 0.1417 0.1412
Loa Loa (eye worm) animal heme peroxidase 0.0115 0.0552 0.0546
Schistosoma mansoni neuropeptide receptor 0.0019 0.0026 0.002
Schistosoma mansoni tyrosine kinase 0.0978 0.5277 0.5274
Loa Loa (eye worm) hypothetical protein 0.0019 0.0023 0.0017
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0102 0.0394
Loa Loa (eye worm) doublecortin family protein 0.0022 0.0039 0.0034
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0095 0.0442 0.0436
Entamoeba histolytica hypothetical protein 0.0108 0.0511 0.3384
Echinococcus granulosus Niemann Pick C1 protein 0.0278 0.1445 0.144
Schistosoma mansoni rab6-interacting 0.0022 0.0039 0.0034
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0537 0.2862 0.2857
Schistosoma mansoni smad 0.0017 0.0013 0.0007
Schistosoma mansoni hypothetical protein 0.0273 0.1417 0.1412
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0026 0.002
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0161 0.0804 0.0799
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0095 0.0442 0.0436
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0019 0.0026 0.002
Echinococcus granulosus g protein coupled receptor 0.0019 0.0026 0.002
Toxoplasma gondii ABC1 family protein 0.0072 0.0317 0.4446
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0042 0.015 0.0144
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0047 0.0331
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0033 0.0027
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0047 0.0042
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0031 0.0088 0.0541
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0161 0.0804 0.5526
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0084 0.0379 0.0373
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0013 0.0007
Echinococcus granulosus neuropeptide receptor A26 0.0019 0.0026 0.002
Plasmodium falciparum JmjC domain-containing protein, putative 0.0017 0.0015 0.0037
Brugia malayi nuclear hormone receptor 0.0095 0.0442 0.0436
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.011 0.0104
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0019 0.0026 0.002
Echinococcus granulosus neuropeptide receptor 0.0019 0.0026 0.002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.043 0.0424
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0026 0.002
Loa Loa (eye worm) hypothetical protein 0.0115 0.0552 0.0546
Loa Loa (eye worm) hypothetical protein 0.0045 0.0167 0.0161
Loa Loa (eye worm) MBCTL1 0.0117 0.056 0.0555
Loa Loa (eye worm) hypothetical protein 0.0115 0.0552 0.0546
Brugia malayi Animal haem peroxidase family protein 0.0118 0.0565 0.0559
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0007 0.0009
Brugia malayi MH2 domain containing protein 0.0246 0.1266 0.1261
Echinococcus granulosus Polycystic kidney disease protein 0.0022 0.0039 0.0034
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0017 0.0012 0.0006
Loa Loa (eye worm) hypothetical protein 0.0084 0.0379 0.0373
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0161 0.0804 0.0799
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0059 0.0053
Brugia malayi MH2 domain containing protein 0.0017 0.0013 0.0007
Loa Loa (eye worm) hypothetical protein 0.0522 0.278 0.2775
Mycobacterium ulcerans short chain dehydrogenase 0.0272 0.1408 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.0009
Loa Loa (eye worm) hypothetical protein 0.0272 0.1411 0.1406
Echinococcus granulosus death domain containing protein 0.0016 0.0007 0.0001
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.043 0.0424
Schistosoma mansoni neuropeptide receptor 0.0019 0.0026 0.002
Schistosoma mansoni tyrosine kinase 0.0989 0.5338 0.5336
Mycobacterium ulcerans hypothetical protein 0.0072 0.0317 0.2218
Echinococcus granulosus neuropeptides capa receptor 0.0019 0.0026 0.002
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0062 0.0262 0.3155
Brugia malayi GnHR receptor homolog 0.0019 0.0026 0.002
Echinococcus granulosus sterol regulatory element binding protein 0.0084 0.0379 0.0373
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0026 0.002
Loa Loa (eye worm) hypothetical protein 0.012 0.0581 0.0575
Echinococcus multilocularis dnaJ subfamily B 0.0405 0.2141 0.2136
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0012 0.0084
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0019 0.0026 0.002
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0309 0.1613 0.5778
Schistosoma mansoni nuclear receptor 0.0045 0.0167 0.0161
Brugia malayi Animal haem peroxidase family protein 0.0115 0.0552 0.0546
Onchocerca volvulus 0.0019 0.0026 0.0031
Echinococcus granulosus g protein coupled receptor 0.0019 0.0026 0.002
Schistosoma mansoni tyrosine kinase 0.0989 0.5338 0.5336
Echinococcus granulosus 7tm_1 domain containing protein 0.0019 0.0026 0.002
Brugia malayi jmjC domain containing protein 0.0017 0.0015 0.0009
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0102 0.0394
Echinococcus multilocularis g protein coupled receptor 0.0019 0.0026 0.002
Brugia malayi ORL1-like opioid receptor 0.0019 0.0026 0.002
Loa Loa (eye worm) nuclear receptor NHR-67 0.0045 0.0167 0.0161
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0019 0.0026 0.002
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0015 0.0009
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.002
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.0031 0.0088 0.0082
Brugia malayi hypothetical protein 0.0272 0.1411 0.1406
Brugia malayi Intermediate filament tail domain containing protein 0.006 0.0252 0.0247
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0042 0.015 0.075
Echinococcus multilocularis phd:f box containing protein 0.0017 0.0015 0.0009
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0026 0.002
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0095 0.0442 0.0436
Echinococcus granulosus cpg binding protein 0.0066 0.0282 0.0276
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0059 0.0053
Plasmodium vivax SET domain protein, putative 0.0032 0.0095 0.1177
Brugia malayi Nuclear hormone receptor E75 0.0045 0.0167 0.0161
Schistosoma mansoni intermediate filament proteins 0.006 0.0252 0.0247
Echinococcus granulosus G protein coupled receptor 139 0.0019 0.0026 0.002
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.0317 0.0311
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.0317 0.1272
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.002
Echinococcus granulosus geminin 0.0712 0.3819 0.3815
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0095 0.0442 0.0436
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0273 0.1417 1
Leishmania major farnesyltransferase beta subunit 0.0031 0.0088 0.062
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0042 0.015 0.0144
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0335 0.1753 0.1748
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.0201 0.1022 0.1016
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0161 0.0804 0.5638
Mycobacterium leprae Probable lipase LipE 0.0072 0.0317 0.5341
Echinococcus granulosus snurportin 1 0.0335 0.1753 0.1748
Loa Loa (eye worm) hypothetical protein 0.0035 0.0113 0.0107
Loa Loa (eye worm) Smad1 0.0017 0.0013 0.0007
Loa Loa (eye worm) hypothetical protein 0.0029 0.0081 0.0075
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0178 0.0172
Echinococcus granulosus insulin receptor 0.0589 0.3145 0.3141
Plasmodium falciparum geranylgeranyltransferase, putative 0.0031 0.0088 0.0959
Brugia malayi CXXC zinc finger family protein 0.0062 0.0262 0.0257
Schistosoma mansoni neuropeptide f receptor 76f 0.0019 0.0026 0.002
Brugia malayi Nuclear hormone receptor-like 1 0.1217 0.6588 0.6586
Onchocerca volvulus 0.0045 0.0167 0.0542
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0013 0.0007
Brugia malayi G protein-coupled receptor 0.0019 0.0026 0.002
Onchocerca volvulus 0.0019 0.0026 0.0031
Echinococcus multilocularis epidermal growth factor receptor 0.184 1 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0252 0.0247
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0031 0.0088 0.0541
Trichomonas vaginalis set domain proteins, putative 0.0242 0.1247 0.8787
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0012 0.0006
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0062 0.0262 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.002
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0019 0.0026 0.002
Plasmodium vivax JmjC domain containing protein 0.0017 0.0015 0.0189
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.011 0.0521 0.885
Loa Loa (eye worm) hypothetical protein 0.0031 0.0088 0.0082
Echinococcus multilocularis peroxidasin 0.012 0.0581 0.0575
Brugia malayi Latrophilin receptor protein 2 0.0034 0.011 0.0104
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0045 0.0167 0.0542
Loa Loa (eye worm) hypothetical protein 0.005 0.0196 0.0191
Echinococcus multilocularis Smad4 0.0017 0.0013 0.0007
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.002
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.015 0.1021
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0462 0.2451 1
Brugia malayi hypothetical protein 0.0022 0.0039 0.0034
Schistosoma mansoni neuropeptide F-like receptor 0.0019 0.0026 0.002
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0019 0.0026 0.002
Loa Loa (eye worm) runx1 0.0065 0.028 0.0274
Schistosoma mansoni hypothetical protein 0.0636 0.3403 0.3399
Brugia malayi Serotonin receptor 0.0019 0.0026 0.002
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.0273 0.1417 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0093 0.0614
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0017 0.0015 0.0009
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0012 0.0006
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0026 0.002
Plasmodium falciparum LCCL domain-containing protein 0.0022 0.0039 0.0342
Entamoeba histolytica hypothetical protein 0.0108 0.0511 0.3384
Echinococcus multilocularis epidermal growth factor receptor 0.0989 0.5338 0.5336
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0095 0.0089
Echinococcus multilocularis allatostatin A receptor 0.0019 0.0026 0.002
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0178 0.1252
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0042 0.015 0.1021
Loa Loa (eye worm) hypothetical protein 0.0322 0.1687 0.1682
Brugia malayi AKH receptor 0.0019 0.0026 0.002
Brugia malayi Animal haem peroxidase family protein 0.0115 0.0552 0.0546
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0031 0.0088 0.0541
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0012 0.0084
Brugia malayi Niemann-Pick C1 protein precursor 0.0195 0.0987 0.0982
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0178 0.0703
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0084 0.0383 0.2702
Brugia malayi hypothetical protein 0.0019 0.0026 0.002
Onchocerca volvulus 0.0115 0.0552 0.1937
Schistosoma mansoni hypothetical protein 0.0405 0.2141 0.2136
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0012 0.0084
Brugia malayi Doublecortin family protein 0.0022 0.0039 0.0034
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0317 0.2169
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0019 0.0026 0.002
Echinococcus multilocularis ubiquitin specific protease 41 0.0041 0.0143 0.0137
Giardia lamblia Prenyltransferase 0.0031 0.0088 0.0541
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.0031 0.0088 0.0298
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0041 0.0143 0.0137
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0026 0.002
Schistosoma mansoni rab6-interacting 0.0022 0.0039 0.0034
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0019 0.0026 0.002
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0045 0.0167 0.0161
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0095 0.0442 0.0436
Loa Loa (eye worm) hypothetical protein 0.0045 0.0167 0.0161
Schistosoma mansoni hypothetical protein 0.0081 0.0362 0.0356
Loa Loa (eye worm) hypothetical protein 0.0045 0.0167 0.0161
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.002
Brugia malayi Nuclear hormone receptor-like 1 0.1172 0.6342 0.634
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.002
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0178 0.0952
Echinococcus multilocularis FTZ F1 alpha 0.0095 0.0442 0.0436
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0008 0.0095
Brugia malayi hypothetical protein 0.0019 0.0026 0.002
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0015 0.013
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0064 0.0274 0.0268
Brugia malayi nuclear receptor RXR 0.005 0.0196 0.0191
Echinococcus multilocularis Polycystic kidney disease protein 0.0022 0.0039 0.0034
Schistosoma mansoni retinoid-x-receptor (RXR) 0.005 0.0196 0.0191
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0012 0.0084
Schistosoma mansoni smad1 5 8 and 0.0017 0.0013 0.0007
Echinococcus multilocularis G protein coupled receptor 139 0.0019 0.0026 0.002
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0015 0.0104
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.0317 0.0311
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.005 0.0196 0.0191
Treponema pallidum exodeoxyribonuclease (exoA) 0.0062 0.0262 1
Echinococcus granulosus Solute carrier family 22 5 0.1134 0.6132 0.613
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.0273 0.1417 1
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0041 0.0143 0.0137
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.006 0.0341
Brugia malayi putative neuropeptide receptor NPR1 0.0019 0.0026 0.002
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0019 0.0026 0.002
Echinococcus multilocularis snurportin 1 0.0335 0.1753 0.1748
Schistosoma mansoni tyrosine kinase 0.0589 0.3145 0.3141
Schistosoma mansoni transcription factor LCR-F1 0.0108 0.0511 0.0505
Loa Loa (eye worm) TK/EGFR protein kinase 0.184 1 1
Schistosoma mansoni smad1 5 8 and 0.0017 0.0013 0.0007
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.043 0.0424
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0019 0.0026 0.002
Brugia malayi ecdysteroid receptor 0.0095 0.0442 0.0436
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0487 0.2589 0.2584
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0095 0.0442 0.0436
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0064 0.0274 0.0268
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0041 0.0143 0.093
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0039 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0379 0.2608
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0317 0.2235
Loa Loa (eye worm) hypothetical protein 0.0103 0.0482 0.0477
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0015 0.0009
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.005 0.0196 0.0191
Brugia malayi putative neuropeptide receptor 0.0019 0.0026 0.002
Schistosoma mansoni nuclear hormone receptor 0.0045 0.0167 0.0161
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.002
Trichomonas vaginalis ap endonuclease, putative 0.0062 0.0262 0.1779
Echinococcus granulosus tachykinin peptides receptor 99D 0.0019 0.0026 0.002
Giardia lamblia Histone acetyltransferase GCN5 0.0131 0.064 0.4469
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0019 0.0026 0.002
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.0178 0.0952
Plasmodium falciparum ataxin-2 like protein, putative 0.0078 0.0349 0.4248
Loa Loa (eye worm) transcription factor SMAD2 0.0246 0.1266 0.1261
Brugia malayi hypothetical protein 0.0522 0.278 0.2775
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.0059 0.041
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0031 0.0088 0.0959
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0026 0.002
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0012 0.0153
Loa Loa (eye worm) intermediate filament protein 0.006 0.0252 0.0247
Schistosoma mansoni hypothetical protein 0.0034 0.011 0.0104
Leishmania major cytochrome p450-like protein 0.0016 0.0006 0.0039
Giardia lamblia Telomerase catalytic subunit 0.0084 0.0383 0.264
Onchocerca volvulus 0.0019 0.0026 0.0031
Echinococcus multilocularis Niemann Pick C1 protein 0.0195 0.0987 0.0982
Plasmodium vivax glutathione reductase, putative 0.0048 0.0184 0.229
Brugia malayi hypothetical protein 0.0124 0.0599 0.0593
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.0178 0.0703
Schistosoma mansoni retinoic acid receptor RXR 0.0095 0.0442 0.0436
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0095 0.0442 0.0436
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0047 0.025
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0133 0.0651 0.0645
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0095 0.0442 0.0436
Echinococcus multilocularis Protein lozenge 0.0065 0.028 0.0274
Schistosoma mansoni protein phosphatase 2C 0.0017 0.0015 0.0009
Trichomonas vaginalis importin beta-1, putative 0.0025 0.006 0.0341
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0117 0.056 0.0555
Echinococcus granulosus polycomb protein SCMH1 0.0103 0.0482 0.0477
Giardia lamblia Rab geranylgeranyltransferase 0.0042 0.015 0.0981
Loa Loa (eye worm) acetyltransferase 0.0487 0.2589 0.2584
Schistosoma mansoni opsin-like receptor 0.0019 0.0026 0.002
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0016 0.0007 0.0001
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0158 0.0786 0.0781
Loa Loa (eye worm) hypothetical protein 0.0072 0.0317 0.0311
Loa Loa (eye worm) hypothetical protein 0.0047 0.0178 0.0172
Brugia malayi hypothetical protein 0.0019 0.0026 0.002
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.0225 0.0219
Plasmodium falciparum importin beta, putative 0.0031 0.0093 0.1015
Schistosoma mansoni hypothetical protein 0.0081 0.0362 0.0356
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.002
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0001
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0019 0.0026 0.002
Echinococcus multilocularis neuropeptide FF receptor 2 0.0019 0.0026 0.002
Schistosoma mansoni phosphatidylserine receptor 0.0017 0.0015 0.0009
Schistosoma mansoni jumonji/arid domain-containing protein 0.0068 0.0293 0.0288
Echinococcus granulosus thyroid hormone receptor alpha 0.0045 0.0167 0.0161
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0109 0.0517 0.0512
Echinococcus granulosus intermediate filament protein 0.006 0.0252 0.0247
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0178 0.0952
Loa Loa (eye worm) blistered cuticle protein 3 0.0115 0.0552 0.0546
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0201 0.1022 0.7183
Echinococcus multilocularis RUN 0.0022 0.0039 0.0034
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0201 0.1022 0.1016
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0025 0.0059 0.0375
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0108 0.0511 0.0505
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0095 0.0442 0.0436
Trypanosoma cruzi PAB1-binding protein , putative 0.0078 0.0349 0.2458
Brugia malayi Steroid receptor seven-up type 2 0.0095 0.0442 0.0436
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0026 0.002
Loa Loa (eye worm) hypothetical protein 0.0115 0.0552 0.0546
Brugia malayi Tachykinin-like peptides receptor 99D 0.0019 0.0026 0.002
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.005 0.0196 0.0191
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0026 0.002
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0317 0.0311
Loa Loa (eye worm) hypothetical protein 0.005 0.0196 0.0191
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0273 0.1417 1
Brugia malayi Peroxidasin 0.012 0.0581 0.0575
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0022 0.0016
Brugia malayi nuclear receptor NHR-88 0.0095 0.0442 0.0436
Loa Loa (eye worm) hypothetical protein 0.005 0.0196 0.0191
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0015 0.0188
Echinococcus granulosus netrin receptor unc 5 0.0019 0.0024 0.0018
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0047 0.0591
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0143 0.097
Brugia malayi conserved hypotetical protein 0.0045 0.0167 0.0161
Schistosoma mansoni amine GPCR 0.0019 0.0026 0.002
Loa Loa (eye worm) hypothetical protein 0.0115 0.0552 0.0546
Schistosoma mansoni hypothetical protein 0.0081 0.0362 0.0356
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0095 0.0442 0.0436
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0049 0.0262
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0062 0.0262 0.0257
Mycobacterium tuberculosis Probable dehydrogenase 0.011 0.0521 0.2108
Plasmodium falciparum glutathione reductase 0.0048 0.0184 0.2171
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0042 0.015 0.0981
Trichomonas vaginalis ap endonuclease, putative 0.0062 0.0262 0.1779
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0013 0.0007
Echinococcus granulosus FTZ F1 alpha 0.0095 0.0442 0.0436
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.0026 0.002
Brugia malayi Importin beta-1 subunit 0.0031 0.0093 0.0087
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.002
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0317 0.2169
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0019 0.0026 0.002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.002
Schistosoma mansoni alpha-1 adrenergic receptor 0.0019 0.0026 0.002
Brugia malayi Immunoglobulin I-set domain containing protein 0.0019 0.0024 0.0018
Loa Loa (eye worm) hypothetical protein 0.0016 0.0008 0.0002
Schistosoma mansoni nuclear hormone receptor 0.0095 0.0442 0.0436
Brugia malayi hypothetical protein 0.005 0.0197 0.0191
Echinococcus multilocularis sterol regulatory element binding protein 0.0084 0.0379 0.0373
Onchocerca volvulus 0.0072 0.0317 0.1086
Onchocerca volvulus Protein ultraspiracle homolog 0.0095 0.0442 0.1539
Echinococcus multilocularis survival motor neuron protein 1 0.0272 0.1411 0.1406
Loa Loa (eye worm) G-protein coupled receptor 0.0019 0.0026 0.002
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0021 0.0035 0.0029
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0012 0.009
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0161 0.0804 0.5638
Loa Loa (eye worm) hypothetical protein 0.0102 0.0482 0.0476
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.002
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0042 0.015 0.1021
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0198 0.1004 0.0999
Trichomonas vaginalis conserved hypothetical protein 0.0273 0.1417 1
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0589 0.3145 0.3141
Onchocerca volvulus Tyrosine kinase homolog 0.0148 0.0733 0.2592
Brugia malayi MH2 domain containing protein 0.0017 0.0013 0.0007
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0049 0.0043
Plasmodium falciparum thioredoxin reductase 0.0048 0.0184 0.2171
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0019 0.0026 0.002
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0095 0.0442 0.0436
Loa Loa (eye worm) nuclear hormone receptor 0.0045 0.0167 0.0161
Schistosoma mansoni peroxidasin 0.0115 0.0552 0.0546
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0042 0.015 0.0144
Echinococcus multilocularis dro:myosuppressin receptor 0.0019 0.0026 0.002
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0592 0.3166 0.3162
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0015 0.0009
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0012 0.0006
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0019 0.0026 0.002
Mycobacterium tuberculosis Probable reductase 0.011 0.0521 0.2108
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.0201 0.1022 0.7111
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0062 0.0262 0.1568
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.0031 0.0088 0.1097
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0032 0.0099 0.0093
Brugia malayi follicle stimulating hormone receptor 0.0019 0.0026 0.002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.002
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0062 0.0262 0.1816
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0062 0.0262 0.0257
Loa Loa (eye worm) hypothetical protein 0.0035 0.0113 0.0107
Schistosoma mansoni amine GPCR 0.0019 0.0026 0.002
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0016 0.0006 0.0039
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0012 0.0084
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0015 0.013
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0039 0.0034
Brugia malayi larval opioid receptor 0.0019 0.0026 0.002
Trypanosoma brucei lanosterol synthase 0.0031 0.0088 0.0583
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.011 0.0104
Brugia malayi Cytochrome P450 family protein 0.0025 0.0059 0.0053
Echinococcus granulosus Protein patched homolog 1 0.0084 0.0379 0.0373
Brugia malayi RNA, U transporter 1 0.0089 0.0409 0.0403
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0042 0.015 0.0144
Brugia malayi Smad1 0.0017 0.0013 0.0007
Echinococcus multilocularis GPCR, family 2 0.0034 0.011 0.0104
Schistosoma mansoni ap endonuclease 0.0062 0.0262 0.0257
Echinococcus granulosus nuclear factor of activated T cells 5 0.0081 0.0363 0.0357
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0095 0.0442 0.0436
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0045 0.0167 0.0161
Loa Loa (eye worm) hypothetical protein 0.0115 0.0552 0.0546
Loa Loa (eye worm) hypothetical protein 0.0078 0.0349 0.0343
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0026 0.002
Schistosoma mansoni ap endonuclease 0.0062 0.0262 0.0257
Giardia lamblia Rab geranylgeranyltransferase 0.0031 0.0088 0.0541
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0016 0.0007 0.0001
Mycobacterium tuberculosis Conserved protein 0.0072 0.0317 0.1272
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0047 0.0443
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0117 0.056 0.0555
Loa Loa (eye worm) hypothetical protein 0.0115 0.0552 0.0546
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.0317 0.1272
Loa Loa (eye worm) hypothetical protein 0.0034 0.011 0.0104
Brugia malayi ecdysone receptor 0.0045 0.0167 0.0161
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0042 0.015 0.174
Schistosoma mansoni neuropeptide F-like receptor 0.0019 0.0026 0.002
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0122 0.0588 0.2382
Onchocerca volvulus 0.0056 0.0225 0.0753
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0031 0.0088 0.0336
Leishmania major cytochrome p450-like protein 0.0016 0.0006 0.0039
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.002
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0015 0.0104
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0015 0.0009
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.011 0.0104
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0117 0.056 0.0555
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.002
Echinococcus granulosus JmjC domain containing protein 4 0.0017 0.0015 0.0009
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0045 0.0167 0.0161
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.002
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0317 0.2235
Onchocerca volvulus 0.0103 0.0482 0.1685
Loa Loa (eye worm) hypothetical protein 0.0072 0.0317 0.0311
Loa Loa (eye worm) melatonin receptor type 1A 0.0019 0.0026 0.002
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.015 0.1056
Echinococcus granulosus nuclear receptor nhr 48 0.0045 0.0167 0.0161
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0019 0.0026 0.002
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0143 0.1006
Loa Loa (eye worm) hypothetical protein 0.1167 0.6312 0.631
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0317 0.2204
Brugia malayi Dopamine receptor protein 2 0.0019 0.0026 0.002
Echinococcus multilocularis Ankyrin 0.0016 0.0008 0.0002
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0119 0.0575 0.4008
Echinococcus granulosus lamin 0.006 0.0252 0.0247
Brugia malayi Dopamine receptor protein 1 0.0019 0.0026 0.002
Schistosoma mansoni hypothetical protein 0.0034 0.011 0.0104
Echinococcus granulosus biogenic amine 5HT receptor 0.0019 0.0026 0.002
Echinococcus granulosus serotonin receptor 0.0019 0.0026 0.002
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0273 0.1417 1
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0317 0.3941
Loa Loa (eye worm) neuropeptide F receptor 0.0019 0.0026 0.002
Schistosoma mansoni cpg binding protein 0.0066 0.0282 0.0276
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.002
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0095 0.0089
Loa Loa (eye worm) cytochrome P450 family protein 0.0057 0.0235 0.0229
Echinococcus granulosus peroxidasin 0.012 0.0581 0.0575
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0019 0.0026 0.002
Schistosoma mansoni nuclear receptor 0.0045 0.0167 0.0161
Plasmodium vivax telomerase reverse transcriptase, putative 0.0084 0.0383 0.4764
Echinococcus granulosus dnaJ subfamily B 0.0405 0.2141 0.2136
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0095 0.0442 0.0436
Loa Loa (eye worm) hypothetical protein 0.0022 0.0039 0.0034
Echinococcus granulosus neuropeptide receptor 0.0019 0.0026 0.002
Echinococcus multilocularis lamin 0.006 0.0252 0.0247
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.0273 0.1417 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.006 0.0252 0.0247
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0045 0.0167 0.0542
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0122 0.0588 1
Onchocerca volvulus 0.0019 0.0026 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0095 0.0442 0.0436
Schistosoma mansoni amine GPCR 0.0019 0.0026 0.002
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0031 0.0088 0.0541
Brugia malayi MH1 domain containing protein 0.0017 0.0013 0.0007
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0047 0.0042
Echinococcus multilocularis thyroid hormone receptor alpha 0.0688 0.3687 0.3683
Schistosoma mansoni RAR-like nuclear receptor 0.0095 0.0442 0.0436
Plasmodium vivax multidomain scavenger receptor, putative 0.0022 0.0039 0.049
Echinococcus granulosus histone acetyltransferase MYST2 0.0117 0.056 0.0555
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0178 0.0172
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.002
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0031 0.0088 0.0541
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0019 0.0026 0.002
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0317 0.2169
Schistosoma mansoni hypothetical protein 0.0074 0.0329 0.0323
Brugia malayi MH1 domain containing protein 0.0017 0.0013 0.0007
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0095 0.0442 0.0436
Echinococcus granulosus Niemann Pick C1 protein 0.0195 0.0987 0.0982
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0017 0.0015 0.0131
Loa Loa (eye worm) hypothetical protein 0.0045 0.0167 0.0161
Brugia malayi acetyltransferase, GNAT family protein 0.0487 0.2589 0.2584
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0081 0.0075
Echinococcus granulosus epidermal growth factor receptor 0.0989 0.5338 0.5336
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0095 0.0442 0.0436
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0161 0.0804 1
Schistosoma mansoni tyrosine kinase 0.0978 0.5277 0.5274
Echinococcus granulosus mixed lineage leukemia protein mll 0.0017 0.0012 0.0006
Loa Loa (eye worm) mbt repeat family protein 0.0103 0.0482 0.0477
Brugia malayi beta-lactamase 0.0072 0.0317 0.0311
Loa Loa (eye worm) animal heme peroxidase 0.0115 0.0552 0.0546
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.043 0.0424
Leishmania major geranylgeranyltransferase, putative 0.0031 0.0088 0.062
Toxoplasma gondii exonuclease III APE 0.0062 0.0262 0.3663
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0095 0.0089
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0095 0.0089
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0019 0.0026 0.002
Echinococcus granulosus histone acetyltransferase KAT2B 0.0473 0.2514 0.251
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0317 0.2169
Schistosoma mansoni cpg binding protein 0.0062 0.0262 0.0257
Echinococcus granulosus ATP dependent DNA helicase PIF1 0.0273 0.1417 0.1412
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0095 0.0442 0.0436
Brugia malayi nuclear receptor RXR 0.0045 0.0167 0.0161
Brugia malayi hypothetical protein 0.0019 0.0026 0.002
Echinococcus granulosus dro:myosuppressin receptor 0.0019 0.0026 0.002
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0033 0.0027
Schistosoma mansoni importin beta-1 0.0031 0.0093 0.0087
Loa Loa (eye worm) hypothetical protein 0.0072 0.0317 0.0311
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0016 0.0007 0.0001
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.0317 0.1272
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.002
Schistosoma mansoni hypothetical protein 0.0081 0.0362 0.0356
Loa Loa (eye worm) hypothetical protein 0.0522 0.278 0.2775
Schistosoma mansoni tyrosine kinase 0.0589 0.3145 0.3141
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0184 0.0178
Schistosoma mansoni sex comb on midleg homolog 0.0103 0.0482 0.0477
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0184 0.0178
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0143 0.0706 1
Onchocerca volvulus 0.0019 0.0026 0.0031
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0161 0.0804 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0039 0.0034
Loa Loa (eye worm) hypothetical protein 0.0031 0.0093 0.0087
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0013 0.0007
Loa Loa (eye worm) hypothetical protein 0.0095 0.0442 0.0436
Brugia malayi latrophilin 2 splice variant baaae 0.0074 0.0329 0.0323
Brugia malayi beta-lactamase family protein 0.0072 0.0317 0.0311
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0012 0.0084
Brugia malayi neuropeptide F receptor 0.0019 0.0026 0.002
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0042 0.015 0.1056
Echinococcus granulosus g-protein coupled receptor 0.0019 0.0026 0.002
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.0317 0.0311
Echinococcus granulosus neuropeptide s receptor 0.0019 0.0026 0.002
Brugia malayi hypothetical protein 0.0019 0.0026 0.002
Echinococcus multilocularis SAM and MBT domain containing protein 0.0103 0.0482 0.0477
Loa Loa (eye worm) hypothetical protein 0.0109 0.0517 0.0512
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0042 0.015 0.1866
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.002
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0019 0.0026 0.002
Loa Loa (eye worm) hypothetical protein 0.0045 0.0167 0.0161
Onchocerca volvulus 0.0032 0.0095 0.0281
Brugia malayi nuclear receptor NHR-88 0.0045 0.0167 0.0161
Schistosoma mansoni patched 1 0.0084 0.0379 0.0373
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.011 0.0104
Echinococcus granulosus SAM and MBT domain containing protein 0.0103 0.0482 0.0477
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0019 0.0026 0.002
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0019 0.0026 0.002
Brugia malayi Nuclear hormone receptor-like 1 0.1172 0.6342 0.634
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.0031 0.0088 0.0082
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.002
Onchocerca volvulus 0.0019 0.0026 0.0031
Loa Loa (eye worm) hypothetical protein 0.0028 0.0075 0.0069
Echinococcus granulosus neuropeptide Y receptor 0.0019 0.0026 0.002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0026 0.002
Brugia malayi Dopamine receptor 0.0019 0.0026 0.002
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0103 0.0482 0.0477
Loa Loa (eye worm) hypothetical protein 0.0072 0.0317 0.0311
Brugia malayi Cytochrome P450 family protein 0.0025 0.0059 0.0053
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.0317 0.2218
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0019 0.0026 0.002
Toxoplasma gondii hypothetical protein 0.0119 0.0575 0.8139
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0031 0.0026
Loa Loa (eye worm) hypothetical protein 0.0095 0.0442 0.0436
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.002
Brugia malayi hypothetical protein 0.0019 0.0026 0.002
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0012 0.0045
Schistosoma mansoni histamine h1 receptor 0.0019 0.0026 0.002
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0095 0.0442 0.0436
Schistosoma mansoni thyroid hormone receptor 0.0688 0.3687 0.3683
Schistosoma mansoni amine GPCR 0.0019 0.0026 0.002
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0487 0.2589 0.2584
Echinococcus granulosus peptide allatostatin:somatostatin 0.0019 0.0026 0.002
Loa Loa (eye worm) hypothetical protein 0.0045 0.0167 0.0161
Echinococcus multilocularis nuclear receptor nhr 48 0.0045 0.0167 0.0161
Echinococcus multilocularis fmrfamide receptor 0.0019 0.0026 0.002
Onchocerca volvulus Dual oxidase homolog 0.0115 0.0552 0.1937
Giardia lamblia Rrm3p helicase 0.0273 0.1417 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.0317 0.2218
Echinococcus granulosus expressed conserved protein 0.0183 0.0923 0.0917
Echinococcus multilocularis insulin receptor 0.0589 0.3145 0.3141
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0031 0.0088 0.0082
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0045 0.0167 0.0161
Brugia malayi Immunoglobulin I-set domain containing protein 0.0158 0.0786 0.0781
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0095 0.0442 0.0436
Onchocerca volvulus 0.0022 0.0039 0.0081
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0015 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0095 0.0442 0.0436
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0095 0.0442 0.1539
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.015 0.1056
Schistosoma mansoni neuropeptide receptor 0.0019 0.0026 0.002
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0012 0.0084
Onchocerca volvulus 0.006 0.0252 0.0852
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.1172 0.6342 0.634
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0019 0.0026 0.002
Brugia malayi isocitrate dehydrogenase 0.0017 0.0015 0.0009
Onchocerca volvulus 0.0019 0.0026 0.0031
Loa Loa (eye worm) MH2 domain-containing protein 0.0246 0.1266 0.1261
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0201 0.1022 0.1016
Plasmodium falciparum telomerase reverse transcriptase 0.0084 0.0383 0.4683
Onchocerca volvulus Peroxidasin homolog 0.0118 0.0565 0.1983
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0031 0.0088 0.1175
Loa Loa (eye worm) G-protein coupled receptor 0.0019 0.0026 0.002
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0012 0.0006
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0019 0.0026 0.002
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0045 0.0167 0.0161
Loa Loa (eye worm) hypothetical protein 0.0115 0.0552 0.0546
Echinococcus granulosus smad 0.0017 0.0013 0.0007
Brugia malayi Animal haem peroxidase family protein 0.0115 0.0552 0.0546
Brugia malayi hypothetical protein 0.005 0.0196 0.0191
Echinococcus multilocularis neuropeptide receptor A26 0.0019 0.0026 0.002
Loa Loa (eye worm) hypothetical protein 0.0195 0.0987 0.0982
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.0113 1
Echinococcus granulosus ecdysone induced protein 78C 0.0095 0.0442 0.0436
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0029 0.0081 0.0075
Onchocerca volvulus 0.0019 0.0026 0.0031
Echinococcus granulosus survival motor neuron protein 1 0.0272 0.1411 0.1406
Loa Loa (eye worm) animal heme peroxidase 0.0115 0.0552 0.0546
Echinococcus granulosus histone acetyltransferase KAT2B 0.0143 0.0706 0.07
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.002
Brugia malayi CHE-14 protein 0.0084 0.0379 0.0373
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0113 0.0762
Echinococcus multilocularis fmrfamide receptor 0.0019 0.0026 0.002
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0031 0.0088 0.0082
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0045 0.0167 0.0161
Echinococcus multilocularis neuropeptide s receptor 0.0019 0.0026 0.002
Brugia malayi photoreceptor-specific nuclear receptor 0.0095 0.0442 0.0436
Echinococcus multilocularis neuropeptide Y receptor 0.0019 0.0026 0.002
Echinococcus multilocularis serotonin receptor 0.0019 0.0026 0.002
Loa Loa (eye worm) hypothetical protein 0.0115 0.0552 0.0546
Entamoeba histolytica hypothetical protein 0.0025 0.006 0.0094
Brugia malayi intermediate filament protein 0.006 0.0252 0.0247
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.0031 0.0088 0.062
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.043 0.0424
Loa Loa (eye worm) hypothetical protein 0.0161 0.0804 0.0799
Echinococcus granulosus biogenic amine 5HT receptor 0.0019 0.0026 0.002
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0095 0.0442 0.0436
Mycobacterium tuberculosis Putative ferredoxin reductase 0.011 0.0521 0.2108
Echinococcus multilocularis JmjC domain containing protein 4 0.0017 0.0015 0.0009
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0317 0.2169
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0012 0.0044
Loa Loa (eye worm) CYP4Cod1 0.0025 0.0059 0.0053
Echinococcus multilocularis smad 0.0017 0.0013 0.0007
Echinococcus multilocularis geminin 0.0712 0.3819 0.3815
Brugia malayi hypothetical protein 0.0019 0.0026 0.002
Schistosoma mansoni netrin receptor unc5 0.0019 0.0024 0.0018
Entamoeba histolytica hypothetical protein, conserved 0.0273 0.1417 1
Schistosoma mansoni polycystin 1-related 0.0022 0.0039 0.0034
Entamoeba histolytica DNA repair and recombination protein, putative 0.0273 0.1417 1
Leishmania major hypothetical protein, conserved 0.0072 0.0317 0.2235
Loa Loa (eye worm) hypothetical protein 0.0074 0.0329 0.0323
Loa Loa (eye worm) hypothetical protein 0.0095 0.0442 0.0436
Brugia malayi Nuclear hormone receptor E75 0.0045 0.0167 0.0161
Loa Loa (eye worm) hypothetical protein 0.0115 0.0552 0.0546
Brugia malayi hypothetical protein 0.0045 0.0167 0.0161
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0031 0.0088 0.0583
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.0317 0.0311
Onchocerca volvulus 0.0047 0.0178 0.0582
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.002
Loa Loa (eye worm) hypothetical protein 0.0117 0.056 0.0555
Onchocerca volvulus 0.0019 0.0026 0.0031
Onchocerca volvulus 0.0019 0.0026 0.0031
Echinococcus multilocularis neuropeptide Y receptor 0.0019 0.0026 0.002
Onchocerca volvulus 0.0045 0.0167 0.0542
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.006 0.0252 0.0247
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0122 0.0588 0.2382
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.0178 0.1225
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0019 0.0026 0.002
Leishmania major cytochrome p450-like protein 0.0025 0.0059 0.041
Schistosoma mansoni hypothetical protein 0.0019 0.0026 0.002
Brugia malayi RE15519p 0.0019 0.0026 0.002
Brugia malayi nuclear hormone receptor 0.0045 0.0167 0.0161
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0031 0.0088 0.1175
Schistosoma mansoni jumonji domain containing protein 0.0017 0.0015 0.0009
Schistosoma mansoni ran 0.0023 0.0047 0.0042
Loa Loa (eye worm) hypothetical protein 0.005 0.0196 0.0191
Brugia malayi nuclear receptor NHR-67 0.0045 0.0167 0.0161
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0095 0.0442 0.0436
Schistosoma mansoni biogenic amine (5HT) receptor 0.0019 0.0026 0.002
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0015 0.0009
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1604 0.8704 0.8703
Schistosoma mansoni lamin 0.006 0.0252 0.0247
Loa Loa (eye worm) hypothetical protein 0.0072 0.0317 0.0311
Leishmania major telomerase reverse transcriptase, putative 0.0084 0.0383 0.2702
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0012 0.0044
Echinococcus granulosus RUN 0.0022 0.0039 0.0034
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0016 0.0006 0.0039
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0026 0.002
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0042 0.015 0.1056
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.0143 0.093
Onchocerca volvulus 0.0019 0.0026 0.0031
Echinococcus granulosus neuropeptide Y receptor 0.0019 0.0026 0.002
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0161 0.0804 0.0799
Echinococcus multilocularis lamin dm0 0.006 0.0252 0.0247
Loa Loa (eye worm) hypothetical protein 0.0115 0.0552 0.0546
Schistosoma mansoni thyroid hormone receptor 0.0688 0.3687 0.3683
Brugia malayi beta-lactamase family protein 0.0072 0.0317 0.0311
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0178 0.2951
Mycobacterium ulcerans lipase LipD 0.0072 0.0317 0.2218
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0015 0.0036
Onchocerca volvulus Bile acid receptor homolog 0.0095 0.0442 0.1539
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0081 0.0363 0.0357
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0062 0.0262 0.1779
Trichomonas vaginalis ran, putative 0.0023 0.0047 0.025
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0041 0.0143 0.0137
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0095 0.0089
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0062 0.0262 0.0257
Echinococcus granulosus neuropeptides capa receptor 0.0019 0.0026 0.002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.002
Brugia malayi glutathione reductase 0.0048 0.0184 0.0178
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0012 0.0153
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0026 0.002
Echinococcus multilocularis polycomb protein SCMH1 0.0103 0.0482 0.0477
Echinococcus multilocularis g protein coupled receptor 0.0019 0.0026 0.002
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0.0008 0.0002
Echinococcus multilocularis netrin receptor unc 5 0.0019 0.0024 0.0018
Brugia malayi Uncoordinated protein 44 0.0016 0.0007 0.0001
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0015 0.0009
Trichomonas vaginalis bromodomain-containing protein, putative 0.0143 0.0706 0.4934
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0015 0.0009
Brugia malayi hypothetical protein 0.005 0.0196 0.0191
Entamoeba histolytica hypothetical protein 0.0108 0.0511 0.3384
Echinococcus multilocularis histone acetyltransferase MYST2 0.0117 0.056 0.0555
Loa Loa (eye worm) hypothetical protein 0.0072 0.0317 0.0311
Loa Loa (eye worm) glutathione reductase 0.0048 0.0184 0.0178
Schistosoma mansoni smad1 5 8 and 0.0017 0.0013 0.0007
Trypanosoma brucei PAB1-binding protein , putative 0.0078 0.0349 0.2429
Brugia malayi hypothetical protein 0.0019 0.0026 0.002
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0103 0.0482 0.1685
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0041 0.0143 0.0137
Brugia malayi Serotonin receptor 0.0019 0.0026 0.002
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0049 0.0262
Onchocerca volvulus 0.0062 0.0262 0.0888
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0012 0.0084
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0031 0.0088 0.0298
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0592 0.3166 0.3162
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0095 0.0442 0.0436
Onchocerca volvulus 0.0019 0.0026 0.0031
Trichomonas vaginalis esterase, putative 0.0072 0.0317 0.2169
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0047 0.0293
Brugia malayi hypothetical protein 0.0022 0.0039 0.0034
Loa Loa (eye worm) hypothetical protein 0.0047 0.0178 0.0172
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0035 0.0113 0.0107
Loa Loa (eye worm) hypothetical protein 0.0038 0.0128 0.0122
Loa Loa (eye worm) animal heme peroxidase 0.0118 0.0565 0.0559
Brugia malayi hypothetical protein 0.0045 0.0167 0.0161
Echinococcus granulosus tm gpcr rhodopsin 0.0019 0.0026 0.002
Loa Loa (eye worm) hypothetical protein 0.0095 0.0442 0.0436
Loa Loa (eye worm) hypothetical protein 0.0035 0.0113 0.0107
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0095 0.0442 0.0436
Schistosoma mansoni zinc finger protein 0.0045 0.0167 0.0161
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0178 0.2951
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.0178 0.1225
Plasmodium vivax importin-beta 2, putative 0.0031 0.0093 0.1152
Echinococcus multilocularis lysine specific demethylase 6a 0.0017 0.0015 0.0009
Loa Loa (eye worm) hypothetical protein 0.0028 0.0075 0.0069
Onchocerca volvulus 0.0022 0.0039 0.0081
Trypanosoma cruzi protein farnesyltransferase, putative 0.0031 0.0088 0.062
Trypanosoma cruzi lanosterol synthase, putative 0.0031 0.0088 0.062
Brugia malayi orphan nuclear receptor NR2E1 0.0045 0.0167 0.0161
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0062 0.0262 0.1827
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.0031 0.0088 0.0959
Plasmodium falciparum histone acetyltransferase GCN5 0.0131 0.064 0.7927
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.002
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0019 0.0026 0.002
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0031 0.0088 0.0082
Mycobacterium tuberculosis Probable oxidoreductase 0.0122 0.0588 0.2382
Schistosoma mansoni hypothetical protein 0.0035 0.0113 0.0107
Schistosoma mansoni opsin-like receptor 0.0019 0.0026 0.002
Schistosoma mansoni hypothetical protein 0.0335 0.1753 0.1748
Trypanosoma cruzi protein farnesyltransferase, putative 0.0031 0.0088 0.062
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0012 0.0084
Giardia lamblia Rab geranylgeranyltransferase 0.0161 0.0804 0.5638
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0041 0.0143 0.0137
Loa Loa (eye worm) hypothetical protein 0.0115 0.0552 0.0546
Echinococcus multilocularis protein dispatched 1 0.0095 0.0443 0.0438
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0045 0.0167 0.0161
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0062 0.0262 0.1848
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0213 0.1087 0.1082
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.002
Mycobacterium tuberculosis Conserved protein 0.0072 0.0317 0.1272
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.0031 0.0088 0.0583
Schistosoma mansoni biogenic amine (5HT) receptor 0.0019 0.0026 0.002
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.0031 0.0088 0.0082
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0019 0.0026 0.002
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0088 0.062
Loa Loa (eye worm) DEAH box polypeptide 35 0.0038 0.0128 0.0122
Brugia malayi Calcitonin receptor-like protein seb-1 0.0109 0.0517 0.0512
Onchocerca volvulus 0.0115 0.0552 0.1937
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0273 0.1417 1
Echinococcus multilocularis neuropeptide receptor 0.0019 0.0026 0.002
Leishmania major hypothetical protein, conserved 0.0078 0.0349 0.2458
Schistosoma mansoni hypothetical protein 0.0056 0.0225 0.0219
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0012 0.0006
Echinococcus granulosus importin subunit beta 1 0.0031 0.0093 0.0087
Brugia malayi hypothetical protein 0.0108 0.0511 0.0505
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0015 0.0009
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.0201 0.1022 0.1016
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.0026 0.002
Plasmodium falciparum ataxin-2 like protein, putative 0.0078 0.0349 0.4248
Brugia malayi hypothetical protein 0.0019 0.0026 0.002
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0012 0.0045
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0015 0.0064
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0049 0.0043
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0178 0.1225
Schistosoma mansoni peroxidasin 0.0118 0.0568 0.0563
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0178 0.1252
Leishmania major GTP-binding protein, putative 0.0023 0.0047 0.0331
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0095 0.0442 0.0436
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0113 0.0437
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0015 0.0104
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.002
Loa Loa (eye worm) TK/INSR protein kinase 0.0589 0.3145 0.3141
Loa Loa (eye worm) hypothetical protein 0.0095 0.0442 0.0436
Brugia malayi Telomerase reverse transcriptase 0.0225 0.1151 0.1146
Schistosoma mansoni amine GPCR 0.0019 0.0026 0.002
Loa Loa (eye worm) hypothetical protein 0.0045 0.0167 0.0161
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0026 0.002
Loa Loa (eye worm) hypothetical protein 0.0047 0.0178 0.0172
Loa Loa (eye worm) hypothetical protein 0.0045 0.0167 0.0161
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0184 0.0729
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0201 0.1022 0.1016
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0012 0.0084
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.043 0.0424
Echinococcus multilocularis g protein coupled receptor 0.0019 0.0026 0.002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.002
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0102 0.0394
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0045 0.0167 0.0161
Brugia malayi hypothetical protein 0.0019 0.0026 0.002
Loa Loa (eye worm) hypothetical protein 0.0095 0.0442 0.0436
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.011 0.0521 0.2108
Schistosoma mansoni hypothetical protein 0.0034 0.011 0.0104
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.0026 0.002
Schistosoma mansoni adenoreceptor 0.0019 0.0026 0.002
Echinococcus multilocularis ecdysone induced protein 78C 0.0095 0.0442 0.0436
Schistosoma mansoni growth hormone secretagogue receptor 0.0019 0.0026 0.002
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0034 0.0269
Onchocerca volvulus Netrin receptor homolog 0.0018 0.002 0.0011
Mycobacterium ulcerans hypothetical protein 0.0047 0.0178 0.1225
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0012 0.0045
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0041 0.0143 0.0137
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0013 0.0007
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0019 0.0026 0.002
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.0317 0.1272
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0031 0.0088 0.0082
Brugia malayi Pre-SET motif family protein 0.0032 0.0095 0.0089
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0109 0.0517 0.0512
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0041 0.0143 0.0137
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0026 0.002
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0178 0.1225
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0195 0.0987 0.6861
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0026 0.002
Loa Loa (eye worm) hypothetical protein 0.0035 0.0113 0.0107
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0042 0.015 0.0144
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0045 0.0167 0.0161
Brugia malayi mbt repeat family protein 0.0103 0.0482 0.0477
Schistosoma mansoni Smad4 0.0017 0.0013 0.0007
Echinococcus granulosus allatostatin A receptor 0.0019 0.0026 0.002
Loa Loa (eye worm) jmjC domain-containing protein 0.0068 0.0293 0.0288
Onchocerca volvulus Peroxidase homolog 0.0115 0.0552 0.1937
Onchocerca volvulus 0.0135 0.0659 0.2323
Echinococcus granulosus Nuclear hormone receptor HR96 0.0045 0.0167 0.0161
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0019 0.0026 0.002
Loa Loa (eye worm) beta-lactamase 0.0072 0.0317 0.0311
Schistosoma mansoni hypothetical protein 0.0712 0.3819 0.3815
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0062 0.0262 0.1848
Onchocerca volvulus 0.0115 0.0552 0.1937
Loa Loa (eye worm) hypothetical protein 0.0115 0.0552 0.0546
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0019 0.0026 0.002
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0042 0.015 0.1021
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.002
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.0317 0.1272
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0093 0.1239
Brugia malayi cytoplasmic intermediate filament protein 0.0032 0.0099 0.0093
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0012 0.0044
Onchocerca volvulus 0.0019 0.0026 0.0031
Schistosoma mansoni lipoxygenase 0.0022 0.0039 0.0034
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0095 0.0089
Brugia malayi jmjC domain containing protein 0.0017 0.0015 0.0009
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0088 0.062
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0143 0.093
Schistosoma mansoni lamin 0.006 0.0252 0.0247
Onchocerca volvulus Chorion peroxidase homolog 0.0115 0.0552 0.1937
Schistosoma mansoni hypothetical protein 0.0712 0.3819 0.3815
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0095 0.0442 0.0436
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0012 0.009
Onchocerca volvulus 0.0019 0.0026 0.0031
Leishmania major importin beta-1 subunit, putative 0.0025 0.006 0.0422
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0026 0.002
Trypanosoma brucei trypanothione reductase 0.0048 0.0184 0.1263
Onchocerca volvulus 0.0019 0.0026 0.0031
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0184 0.0178
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0026 0.002
Schistosoma mansoni hypothetical protein 0.0019 0.0026 0.002
Loa Loa (eye worm) RecQ helicase 0.0023 0.0049 0.0043
Echinococcus multilocularis lysine specific demethylase 5A 0.0064 0.0274 0.0268
Echinococcus granulosus Nuclear hormone receptor HR96 0.0045 0.0167 0.0161
Brugia malayi G protein-coupled receptor F59B2.13 0.0019 0.0026 0.002
Onchocerca volvulus Peroxidase homolog 0.0115 0.0552 0.1937
Echinococcus granulosus g protein coupled receptor 0.0019 0.0026 0.002
Schistosoma mansoni survival motor neuron protein 0.0056 0.0225 0.0219
Brugia malayi hypothetical protein 0.0115 0.0552 0.0546
Echinococcus multilocularis cpg binding protein 0.0066 0.0282 0.0276
Echinococcus granulosus lamin dm0 0.006 0.0252 0.0247
Schistosoma mansoni steroid hormone receptor ad4bp 0.0095 0.0442 0.0436
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.0317 0.1272
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.002
Brugia malayi exodeoxyribonuclease III family protein 0.0062 0.0262 0.0257
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0042 0.015 0.1056
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0012 0.0044
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.043 0.0424
Brugia malayi jmjC domain containing protein 0.0017 0.0015 0.0009
Schistosoma mansoni ran 0.0023 0.0047 0.0042
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.0178 0.1225
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0045 0.0167 0.0161
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0019 0.0026 0.0031
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0026 0.002
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0016 0.0006 0.0039
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0417 0.2202 0.2198
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0012 0.0084
Leishmania major hypothetical protein, conserved 0.0017 0.0015 0.0104
Schistosoma mansoni lozenge 0.0065 0.028 0.0274
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0031 0.0088 0.0541
Brugia malayi Melatonin receptor type 1A 0.0019 0.0026 0.002
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0095 0.0442 0.0436
Onchocerca volvulus 0.0095 0.0442 0.1539
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.043 0.0424
Leishmania major trypanothione reductase 0.0048 0.0184 0.1297
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0143 0.0706 0.8771
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0589 0.3145 0.3141
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.0031 0.0088 0.1175
Echinococcus granulosus lysine specific demethylase 6a 0.0017 0.0015 0.0009
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0093 0.0614
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0417 0.2202 0.2198
Schistosoma mansoni cpg binding protein 0.0066 0.0282 0.0276
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.011 0.0104
Loa Loa (eye worm) steroid hormone receptor 0.0095 0.0442 0.0436
Schistosoma mansoni myelin transcription factor 1 myt1 0.0117 0.056 0.0555
Echinococcus granulosus arachidonate 5 lipoxygenase 0.006 0.0252 0.0247
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0016 0.0006 0.0039
Brugia malayi Probable ATP-dependent helicase DHX35 0.0038 0.0128 0.0122
Plasmodium vivax geranylgeranyltransferase, putative 0.0031 0.0088 0.1097
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0026 0.002
Brugia malayi G-protein coupled receptor 0.0019 0.0026 0.002
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0019 0.0026 0.002
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0017 0.0015 0.0065
Echinococcus granulosus sex peptide receptor 0.0019 0.0026 0.002
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.006 0.0341
Brugia malayi hypothetical protein 0.0078 0.0349 0.0343
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0143 0.0706 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0026 0.002
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0031 0.0088 0.0541
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0201 0.1022 0.1016
Brugia malayi jmjC domain containing protein 0.0017 0.0015 0.0009
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.011 0.0104
Brugia malayi jmjC domain containing protein 0.0068 0.0293 0.0288
Mycobacterium leprae conserved hypothetical protein 0.0072 0.0317 0.5341
Brugia malayi Protein kinase domain containing protein 0.0016 0.0007 0.0001
Onchocerca volvulus 0.0072 0.0317 0.1086
Onchocerca volvulus 0.0072 0.0317 0.1086
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0015 0.0104
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0019 0.0026 0.002
Entamoeba histolytica hypothetical protein 0.0108 0.0511 0.3384
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.002
Brugia malayi steroid hormone receptor 0.0095 0.0442 0.0436
Echinococcus multilocularis jumonji domain containing 1A 0.0017 0.0015 0.0009
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.011 0.0521 0.2108
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0015 0.0104
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0161 0.0804 0.5638
Brugia malayi jmjC domain containing protein 0.0064 0.0274 0.0268
Toxoplasma gondii LsmAD domain-containing protein 0.0078 0.0349 0.4899
Toxoplasma gondii hypothetical protein 0.0042 0.015 0.206
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0042 0.015 0.1056
Brugia malayi Protein kinase domain containing protein 0.0589 0.3145 0.3141
Echinococcus granulosus tm gpcr rhodopsin 0.0019 0.0026 0.002
Brugia malayi Blistered cuticle protein 3 0.0115 0.0552 0.0546
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0093 0.0087
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0047 0.0331
Brugia malayi Animal haem peroxidase family protein 0.0115 0.0552 0.0546
Loa Loa (eye worm) hypothetical protein 0.005 0.0196 0.0191
Brugia malayi G-protein coupled receptor 0.0019 0.0026 0.002
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0019 0.0026 0.002
Echinococcus multilocularis 0.0569 0.3039 0.3035
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0019 0.0026 0.002
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0031 0.0088 0.1097
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0041 0.0143 0.0698
Trypanosoma brucei telomerase reverse transcriptase 0.0084 0.0383 0.2673
Loa Loa (eye worm) hypothetical protein 0.0045 0.0167 0.0161
Schistosoma mansoni coup transcription factor 0.0095 0.0442 0.0436
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.0317 0.1272
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0084 0.0383 0.2702
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0015 0.0037
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.002
Echinococcus multilocularis expressed conserved protein 0.0183 0.0923 0.0917
Loa Loa (eye worm) hypothetical protein 0.0041 0.0143 0.0137
Schistosoma mansoni hypothetical protein 0.0108 0.0511 0.0505
Schistosoma mansoni hypothetical protein 0.0019 0.0026 0.002
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0013 0.0007
Echinococcus granulosus ubiquitin specific protease 41 0.0041 0.0143 0.0137
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0026 0.002
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0108 0.0511 0.0505
Echinococcus multilocularis G-protein coupled receptor, putative 0.0019 0.0026 0.002
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0012 0.0006
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0019 0.0026 0.002
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0095 0.0442 0.0436
Schistosoma mansoni phd/f-box containing protein 0.0017 0.0015 0.0009
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0042 0.015 0.0144
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.002
Schistosoma mansoni tyrosine kinase 0.0978 0.5277 0.5274
Echinococcus multilocularis musashi 0.006 0.0252 0.0247
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0019 0.0026 0.002
Trypanosoma brucei cytochrome P450, putative 0.0025 0.0059 0.0372
Loa Loa (eye worm) hypothetical protein 0.0095 0.0442 0.0436
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0021 0.0035 0.0029
Echinococcus granulosus hypothetical protein 0.0019 0.0026 0.002
Schistosoma mansoni ankyrin 23/unc44 0.0016 0.0007 0.0001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.043 0.0424
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0031 0.0088 0.0082
Onchocerca volvulus Neuropeptide F receptor homolog 0.0019 0.0026 0.0031
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0039 0.0034
Schistosoma mansoni hypothetical protein 0.0016 0.0007 0.0001
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0178 0.1225
Loa Loa (eye worm) CXXC zinc finger family protein 0.0062 0.0262 0.0257
Schistosoma mansoni jumonji domain containing protein 0.0064 0.0274 0.0268
Echinococcus multilocularis neuropeptides capa receptor 0.0019 0.0026 0.002
Loa Loa (eye worm) hypothetical protein 0.0031 0.0088 0.0082
Toxoplasma gondii histone lysine methyltransferase SET1 0.0131 0.0639 0.9047
Plasmodium vivax ataxin-2 like protein, putative 0.0078 0.0349 0.4335
Schistosoma mansoni lipoxygenase 0.006 0.0252 0.0247
Brugia malayi sulfakinin receptor protein 0.0019 0.0026 0.002
Onchocerca volvulus 0.0042 0.015 0.0482
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0095 0.0442 0.0436
Schistosoma mansoni sex comb on midleg homolog 0.0103 0.0482 0.0477
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0095 0.1267
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0031 0.0088 0.0541
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.002
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0095 0.0442 0.0436
Echinococcus granulosus jumonji domain containing 1A 0.0017 0.0015 0.0009
Schistosoma mansoni biogenic amine receptor 0.0019 0.0026 0.002
Loa Loa (eye worm) hypothetical protein 0.0059 0.0246 0.0241
Onchocerca volvulus 0.0522 0.278 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.002
Onchocerca volvulus Peroxidasin homolog 0.0118 0.0565 0.1983
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.002
Schistosoma mansoni biogenic amine receptor 0.0019 0.0026 0.002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0026 0.002
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0012 0.0006
Loa Loa (eye worm) hypothetical protein 0.0095 0.0442 0.0436
Echinococcus granulosus bloom syndrome protein 0.0023 0.0049 0.0043
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.002
Echinococcus multilocularis g-protein coupled receptor 0.0019 0.0026 0.002
Echinococcus granulosus GPCR family 2 0.0034 0.011 0.0104
Schistosoma mansoni myosin xvIII 0.0019 0.0026 0.002
Mycobacterium tuberculosis Probable oxidoreductase 0.0272 0.1408 0.5736

Activities

Activity type Activity value Assay description Source Reference
Kd (functional) = 7.6 Antagonist activity on halphaCGRP-induced cAMP accumulation at human neuroblastoma SK-N-MC cells ChEMBL. 16420047
Ki (binding) = 8.4 nM Displacement of [3H-propionyl-K24] from halphaCGRP expressed in human neuroblastoma SK-N-MC cells ChEMBL. 16420047
Ki (binding) = 8.4 nM Displacement of [3H-propionyl-K24] from halphaCGRP expressed in human neuroblastoma SK-N-MC cells ChEMBL. 16420047
pA2 (functional) = 7.6 Antagonist activity on halphaCGRP-induced cAMP accumulation at human neuroblastoma SK-N-MC cells ChEMBL. 16420047

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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