Detailed information for compound 418731

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1047.21 | Formula: C49H62N10O12S2
  • H donors: 13 H acceptors: 12 LogP: -3.28 Rotable bonds: 19
    Rule of 5 violations (Lipinski): 4
  • SMILES: NCCC[C@@H]1NC(=O)[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](CSSC[C@H](NC(=O)[C@@H](NC1=O)Cc1ccc(cc1)O)C(=O)N[C@H](C(=O)O)C(C)C)NC(=O)[C@H](CC(=O)O)N)Cc1c[nH]c2c1cccc2
  • InChi: 1S/C49H62N10O12S2/c1-26(2)41(49(70)71)59-48(69)39-25-73-72-24-38(57-42(63)32(51)22-40(61)62)47(68)55-35(19-27-9-4-3-5-10-27)44(65)56-37(21-29-23-52-33-12-7-6-11-31(29)33)46(67)53-34(13-8-18-50)43(64)54-36(45(66)58-39)20-28-14-16-30(60)17-15-28/h3-7,9-12,14-17,23,26,32,34-39,41,52,60H,8,13,18-22,24-25,50-51H2,1-2H3,(H,53,67)(H,54,64)(H,55,68)(H,56,65)(H,57,63)(H,58,66)(H,59,69)(H,61,62)(H,70,71)/t32-,34-,35-,36-,37+,38+,39-,41-/m0/s1
  • InChiKey: RULUWBKLLNAQIL-KVNHVDLWSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Urotensin II receptor Starlite/ChEMBL References
Homo sapiens urotensin 2 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni peptide (allatostatin)-like receptor Urotensin II receptor   386 aa 316 aa 24.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni amine GPCR 0.0046 0.015 0.0235
Trichomonas vaginalis calpain, putative 0.002 0.0035 0.0321
Echinococcus multilocularis importin subunit beta 1 0.003 0.008 0.0078
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0068 0.025 0.3091
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0035 0.0137
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0017 0.002 0.0177
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.0376 0.1496
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0021 0.0078
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0044 0.0169
Entamoeba histolytica hypothetical protein 0.0017 0.002 0.0462
Echinococcus multilocularis muscleblind protein 1 0.0306 0.1328 0.1327
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0021 0.0149
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0046 0.015 0.0235
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0021 0.0177
Toxoplasma gondii hypothetical protein 0.002 0.0035 0.0338
Loa Loa (eye worm) hypothetical protein 0.0037 0.0111 0.0438
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.002 0.0035 0.0338
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0068 0.025 0.3091
Brugia malayi DIX domain containing protein 0.0018 0.0025 0.0098
Echinococcus granulosus expressed conserved protein 0.0097 0.038 0.0379
Loa Loa (eye worm) hypothetical protein 0.0049 0.0167 0.0664
Toxoplasma gondii hypothetical protein 0.0018 0.0025 0.0199
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0035 0.0137
Giardia lamblia Cathepsin B precursor 0.0187 0.0788 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0013 0.0004 0.0003
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0017 0.002 0.0075
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.0075
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0021 0.0183
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.015 0.0235
Plasmodium vivax importin-beta 2, putative 0.003 0.008 0.1069
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0015 0.0013
Entamoeba histolytica cysteine proteinase 1, putative 0.0017 0.002 0.0462
Loa Loa (eye worm) hypothetical protein 0.0013 0.0004 0.001
Brugia malayi neuropeptide F receptor 0.0046 0.015 0.06
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0046 0.0152 0.1839
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.002 0.008
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0151 0.0603
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0017 0.002 0.0177
Brugia malayi MH2 domain containing protein 0.0017 0.0019 0.0075
Schistosoma mansoni cpg binding protein 0.003 0.0081 0.0126
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.002 0.0075
Brugia malayi Niemann-Pick C1 protein precursor 0.0103 0.0409 0.1632
Schistosoma mansoni calpain-7 (C02 family) 0.0068 0.025 0.0392
Entamoeba histolytica cysteine protease, putative 0.0017 0.002 0.0462
Mycobacterium leprae Probable pyruvate kinase PykA 0.007 0.0259 0.3785
Brugia malayi Nuclear hormone receptor-like 1 0.0015 0.0011 0.0043
Loa Loa (eye worm) hypothetical protein 0.0037 0.0111 0.0438
Echinococcus multilocularis survival motor neuron protein 1 0.0247 0.1061 0.106
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0167 0.2032
Trypanosoma brucei pyruvate kinase 1, putative 0.007 0.0259 0.3203
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0105 0.0419 0.8207
Brugia malayi N-terminal motif family protein 0.0365 0.1595 0.6373
Echinococcus granulosus g protein coupled receptor 0.0046 0.015 0.0149
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0009 0.0031
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.015 0.0235
Onchocerca volvulus 0.0017 0.002 0.0118
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0035 0.0338
Schistosoma mansoni cpg binding protein 0.0029 0.0074 0.0114
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.002 0.0177
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.008 0.0905
Entamoeba histolytica cysteine protease, putative 0.0017 0.002 0.0462
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0846 0.3775 0.3775
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0046 0.015 0.0149
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0017 0.002 0.0177
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0068 0.025 0.0994
Plasmodium vivax SET domain protein, putative 0.0032 0.0087 0.1185
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0035 0.0137
Entamoeba histolytica cysteine protease, putative 0.0017 0.002 0.0462
Giardia lamblia Cathepsin L-like protease 0.0017 0.002 0.0126
Onchocerca volvulus Mitochondrial Rho GTPase homolog 0.0015 0.001 0.0057
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.002 0.0177
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.002 0.0019
Toxoplasma gondii preprocathepsin c precursor, putative 0.0017 0.002 0.0141
Giardia lamblia Encystation-specific protease 0.0017 0.002 0.0126
Schistosoma mansoni amine GPCR 0.0046 0.015 0.0235
Leishmania major pyruvate kinase 0.007 0.0259 0.3203
Onchocerca volvulus 0.0049 0.0167 0.1042
Loa Loa (eye worm) hypothetical protein 0.0028 0.0072 0.0281
Echinococcus granulosus regulator of G protein signaling 7 0.0018 0.0025 0.0023
Onchocerca volvulus 0.0046 0.015 0.0935
Brugia malayi hypothetical protein 0.0158 0.0657 0.2626
Loa Loa (eye worm) calpain D 0.002 0.0035 0.0137
Brugia malayi hypothetical protein 0.0025 0.0059 0.0234
Brugia malayi tailless protein 0.0013 0.0004 0.0014
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0102 0.1993
Loa Loa (eye worm) hypothetical protein 0.0158 0.0657 0.2623
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0157 0.1465
Leishmania major hypothetical protein, conserved 0.002 0.0035 0.0338
Trichomonas vaginalis antibiotic synthetase, putative 0.0015 0.0009 0.0074
Leishmania major kinesin, putative 0.0047 0.0158 0.1908
Schistosoma mansoni hypothetical protein 0.0043 0.0136 0.0212
Chlamydia trachomatis pyruvate kinase 0.007 0.0259 0.3673
Brugia malayi calpain family protein 1 0.0179 0.0756 0.3019
Brugia malayi RE15519p 0.0046 0.015 0.06
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.0075
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0044 0.0523
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0105 0.0419 0.6211
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0072 0.007
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0021 0.0149
Plasmodium falciparum serine repeat antigen 3 0.0017 0.002 0.0167
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 0.0177
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0046 0.015 0.0235
Schistosoma mansoni opsin-like receptor 0.0046 0.015 0.0235
Schistosoma mansoni nuclear receptor nhr-48 0.0013 0.0004 0.0004
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0152 0.142
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Echinococcus granulosus FTZ F1 alpha 0.0028 0.0072 0.007
Loa Loa (eye worm) hypothetical protein 0.0028 0.0072 0.0281
Plasmodium falciparum acyl-CoA synthetase 0.0037 0.0111 0.1542
Loa Loa (eye worm) pyruvate kinase 0.007 0.0259 0.1029
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.015 0.0149
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0021 0.0078
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.0167 0.2401
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.002 0.0462
Loa Loa (eye worm) nuclear receptor NHR-67 0.0013 0.0004 0.001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.002 0.0177
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0021 0.0177
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0019 0.0018
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0018 0.0025 0.0023
Onchocerca volvulus Cell death protein 3 homolog 0.0089 0.0347 0.2169
Brugia malayi Dopamine receptor 0.0046 0.015 0.06
Brugia malayi RNA, U transporter 1 0.0086 0.0331 0.1321
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0055 0.0193 0.2791
Brugia malayi hypothetical protein 0.0046 0.015 0.06
Onchocerca volvulus 0.0017 0.002 0.0118
Echinococcus granulosus g-protein coupled receptor 0.0046 0.015 0.0149
Brugia malayi fibroinase precursor 0.0017 0.002 0.008
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0015 0.0009 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.002 0.0177
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0321 0.1398 0.5584
Entamoeba histolytica cysteine protease, putative 0.0017 0.002 0.0462
Onchocerca volvulus Cathepsin L homolog 0.0017 0.002 0.0118
Toxoplasma gondii cathepsin CPC2 0.0017 0.002 0.0141
Brugia malayi Cathepsin L-like precursor 0.0017 0.002 0.008
Echinococcus multilocularis g protein coupled receptor 0.0046 0.015 0.0149
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0187 0.0788 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.002 0.0141
Loa Loa (eye worm) myosin regulatory light chain 1 0.0015 0.001 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.002 0.0177
Loa Loa (eye worm) hypothetical protein 0.0013 0.0004 0.001
Loa Loa (eye worm) hypothetical protein 0.0043 0.0138 0.0547
Echinococcus multilocularis microtubule associated protein 2 0.1413 0.634 0.634
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0028 0.0072 0.0281
Brugia malayi hypothetical protein 0.0046 0.015 0.06
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 0.0177
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0028 0.0072 0.0281
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.0143 0.0142
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0017 0.002 0.0167
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0015 0.0013
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0019 0.0028
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.015 0.0235
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0035 0.0338
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.002 0.0177
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Entamoeba histolytica calpain large subunit domain III containing protein 0.0047 0.0158 0.384
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.0075
Echinococcus granulosus ecdysone induced protein 78C 0.0028 0.0072 0.007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 0.0177
Brugia malayi RasGEF domain containing protein 0.0013 0.0001 0.0004
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0015 0.0011 0.0039
Loa Loa (eye worm) hypothetical protein 0.002 0.0035 0.0137
Onchocerca volvulus 0.0046 0.015 0.0935
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0017 0.002 0.0167
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.002 0.0035 0.0321
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0009 0.0179
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0013 0.0004 0.001
Trypanosoma brucei Calpain-like protein 2 0.002 0.0035 0.0338
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0049 0.0167 0.2401
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0167 0.0662
Echinococcus granulosus somatostatin receptor 0.0046 0.015 0.0149
Echinococcus multilocularis pyruvate kinase 0.0036 0.0105 0.0104
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0049 0.0167 0.2401
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0054 0.021
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0021 0.0149
Plasmodium vivax acyl-CoA synthetase, putative 0.0037 0.0111 0.1542
Trypanosoma cruzi major cysteine proteinase, putative 0.0017 0.002 0.0075
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Loa Loa (eye worm) MH2 domain-containing protein 0.0245 0.1054 0.4207
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.002 0.0177
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0072 0.007
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0017 0.002 0.0075
Brugia malayi hypothetical protein 0.0015 0.0011 0.0043
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.016 0.0668 1
Plasmodium falciparum serine repeat antigen 5 0.0017 0.002 0.0167
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0087 0.0086
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.002 0.0075
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 0.0177
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0021 0.0177
Echinococcus granulosus cpg binding protein 0.003 0.0081 0.008
Brugia malayi hypothetical protein 0.0046 0.015 0.06
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.006 0.0214 0.2636
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.001 0.0036
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.016 0.0668 1
Schistosoma mansoni hypothetical protein 0.0046 0.015 0.0235
Echinococcus granulosus Niemann Pick C1 protein 0.0103 0.0409 0.0407
Echinococcus multilocularis somatostatin receptor 0.0046 0.015 0.0149
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0167 0.4079
Echinococcus granulosus thyroid hormone receptor alpha 0.0013 0.0004 0.0003
Echinococcus granulosus cathepsin L 0.0017 0.002 0.0019
Brugia malayi N-terminal motif family protein 0.0013 0.0001 0.0004
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0017 0.002 0.0126
Echinococcus granulosus peptidase Clp S14 family 0.0105 0.0419 0.0417
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0017 0.002 0.0167
Loa Loa (eye worm) transcription factor SMAD2 0.0245 0.1054 0.4207
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.002 0.0035 0.0321
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Onchocerca volvulus 0.0032 0.0087 0.0539
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0187 0.0788 0.1241
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0046 0.015 0.0149
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.002 0.0035 0.0321
Echinococcus multilocularis programmed cell death protein 0.0023 0.0047 0.0046
Echinococcus granulosus dro:myosuppressin receptor 0.0046 0.015 0.0149
Echinococcus granulosus geminin 0.0177 0.0744 0.0743
Brugia malayi neuropeptide F receptor 0.0046 0.015 0.06
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0009 0.0036
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0044 0.0443
Brugia malayi jmjC domain containing protein 0.0016 0.0015 0.0057
Leishmania major cathepsin L-like protease 0.0017 0.002 0.0141
Leishmania major pyruvate kinase 0.007 0.0259 0.3203
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0028 0.0072 0.0285
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0021 0.0177
Schistosoma mansoni nuclear receptor 0.0013 0.0004 0.0004
Echinococcus granulosus tm gpcr rhodopsin 0.0046 0.015 0.0149
Brugia malayi cathepsin L-like cysteine proteinase 0.0017 0.002 0.008
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.015 0.0149
Giardia lamblia Cathepsin B precursor 0.0017 0.002 0.0126
Brugia malayi serine/threonine-protein kinase plk-2 0.0095 0.0376 0.15
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0028 0.0072 0.007
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0167 0.0668
Brugia malayi MH2 domain containing protein 0.0017 0.0019 0.0075
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0046 0.015 0.0149
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0015 0.0021
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0167 0.0668
Plasmodium falciparum glutathione reductase 0.0017 0.0021 0.0177
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0028 0.0072 0.007
Entamoeba histolytica hypothetical protein 0.0074 0.0277 0.6765
Trichomonas vaginalis calmodulin, putative 0.0015 0.001 0.0085
Trypanosoma cruzi centrin-3 0.0023 0.0047 0.0183
Entamoeba histolytica cysteine protease, putative 0.0017 0.002 0.0462
Schistosoma mansoni ran 0.0022 0.0044 0.0067
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0151 0.015
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0018 0.0025 0.0098
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 0.0177
Echinococcus multilocularis serotonin receptor 0.0046 0.015 0.0149
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0017 0.002 0.0167
Onchocerca volvulus 0.0046 0.015 0.0935
Onchocerca volvulus 0.0046 0.015 0.0935
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 0.0177
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.015 0.0149
Echinococcus multilocularis smad 0.0017 0.0019 0.0018
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0013 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.0013 0.0004 0.001
Echinococcus granulosus segment polarity protein dishevelled 0.0018 0.0025 0.0023
Brugia malayi pyruvate kinase 0.0015 0.001 0.0038
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0017 0.002 0.003
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0013 0.0004 0.0003
Entamoeba histolytica cysteine protease, putative 0.0017 0.002 0.0462
Schistosoma mansoni adenoreceptor 0.0046 0.015 0.0235
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Loa Loa (eye worm) G-protein coupled receptor 0.0046 0.015 0.0596
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.015 0.0235
Onchocerca volvulus 0.0013 0.0004 0.0016
Trypanosoma brucei calpain, putative 0.002 0.0035 0.0338
Schistosoma mansoni caspase-7 (C14 family) 0.0089 0.0347 0.0545
Entamoeba histolytica cysteine protease, putative 0.0017 0.002 0.0462
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.007 0.0259 0.5072
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0017 0.002 0.0462
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.0039
Leishmania major hypothetical protein, conserved 0.0016 0.0015 0.007
Echinococcus granulosus allatostatin A receptor 0.0046 0.015 0.0149
Brugia malayi CXXC zinc finger family protein 0.0029 0.0074 0.0294
Schistosoma mansoni smad1 5 8 and 0.0017 0.0019 0.0028
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0046 0.015 0.0149
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0046 0.015 0.0235
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0072 0.0285
Trypanosoma cruzi conserved protein 0.002 0.0035 0.0137
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.016 0.0668 0.8463
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.002 0.0141
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.002 0.0035 0.0338
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.002 0.008
Echinococcus granulosus calpain 5 0.0068 0.025 0.0249
Giardia lamblia Cathepsin B precursor 0.0017 0.002 0.0126
Loa Loa (eye worm) hypothetical protein 0.0028 0.0072 0.0281
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0102 0.1993
Echinococcus granulosus cathepsin b 0.0565 0.2503 0.2502
Echinococcus multilocularis Niemann Pick C1 protein 0.0147 0.0608 0.0607
Trichomonas vaginalis kakapo, putative 0.0015 0.001 0.0085
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0068 0.025 0.0994
Echinococcus granulosus smad 0.0017 0.0019 0.0018
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0188 0.0793 0.0791
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.002 0.0019
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0009 0.0179
Trypanosoma cruzi centrin, putative 0.0023 0.0047 0.0183
Schistosoma mansoni hypothetical protein 0.005 0.0171 0.0268
Schistosoma mansoni histamine h1 receptor 0.0046 0.015 0.0235
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0152 0.142
Echinococcus multilocularis caspase 0.0122 0.0496 0.0495
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.002 0.0462
Loa Loa (eye worm) hypothetical protein 0.0013 0.0004 0.001
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0009 0.0036
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0028 0.0072 0.0281
Echinococcus multilocularis cathepsin b 0.0565 0.2503 0.2502
Plasmodium vivax metacaspase 1, putative 0.0046 0.0152 0.2173
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.0376 0.1496
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.0022 0.0021
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0017 0.002 0.0167
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0059 0.0636
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0035 0.0338
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0035 0.0338
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0035 0.0338
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0565 0.2503 0.3946
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0152 0.142
Brugia malayi putative neuropeptide receptor NPR1 0.0046 0.015 0.06
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.0214 0.0856
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.001 0.0085
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0167 0.2401
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0015 0.0013
Schistosoma mansoni caspase-3 (C14 family) 0.0122 0.0496 0.0781
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.002 0.0462
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0035 0.0137
Loa Loa (eye worm) cathepsin B 0.0187 0.0788 0.3145
Toxoplasma gondii calmodulin CAM2 0.0015 0.001 0.0015
Echinococcus multilocularis caspase 2 0.0089 0.0347 0.0346
Brugia malayi nuclear receptor NHR-67 0.0013 0.0004 0.0014
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0028 0.0072 0.0111
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Schistosoma mansoni thyroid hormone receptor 0.0028 0.0072 0.0111
Onchocerca volvulus 0.0046 0.015 0.0935
Echinococcus granulosus Smad4 0.0017 0.0019 0.0018
Trypanosoma brucei Metacaspase-4 0.0046 0.0152 0.1839
Echinococcus multilocularis neuropeptides capa receptor 0.0046 0.015 0.0149
Giardia lamblia Cathepsin B precursor 0.0187 0.0788 1
Giardia lamblia Cathepsin B precursor 0.0017 0.002 0.0126
Brugia malayi regulator of G-protein signaling egl-10 0.0018 0.0025 0.0098
Echinococcus granulosus biogenic amine 5HT receptor 0.0046 0.015 0.0149
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 0.0177
Loa Loa (eye worm) hypothetical protein 0.0013 0.0004 0.001
Loa Loa (eye worm) hypothetical protein 0.0037 0.0111 0.0438
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0068 0.025 0.0994
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0125 0.051 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0021 0.0149
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.016 0.0668 0.8463
Onchocerca volvulus Cathepsin L homolog 0.0017 0.002 0.0118
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0028 0.0072 0.0285
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Schistosoma mansoni RAR-like nuclear receptor 0.0028 0.0072 0.0111
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0376 0.3516
Echinococcus granulosus Nuclear hormone receptor HR96 0.0013 0.0004 0.0003
Echinococcus granulosus calcyphosin protein 0.0015 0.001 0.0009
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.002 0.0167
Schistosoma mansoni hypothetical protein 0.0411 0.1802 0.2841
Echinococcus multilocularis calpain 5 0.0068 0.025 0.0249
Onchocerca volvulus 0.0017 0.002 0.0118
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0028 0.0072 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0152 0.142
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0015 0.0009 0.0179
Echinococcus granulosus cathepsin L 0.0017 0.002 0.0019
Mycobacterium ulcerans hypothetical protein 0.0049 0.0167 0.2401
Loa Loa (eye worm) fibroinase 0.0017 0.002 0.0075
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.0143 0.0142
Giardia lamblia Cysteine protease 0.0017 0.002 0.0126
Echinococcus granulosus caspase 8 0.0046 0.0152 0.0151
Schistosoma mansoni Smad4 0.0017 0.0019 0.0028
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0013 0.0004 0.0003
Echinococcus granulosus programmed cell death protein 6 0.0015 0.001 0.0009
Schistosoma mansoni zinc finger protein 0.0013 0.0004 0.0004
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.002 0.008
Onchocerca volvulus Protein ultraspiracle homolog 0.0028 0.0072 0.0441
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0015 0.0009 0.0179
Echinococcus multilocularis cysteine protease 0.0017 0.002 0.0019
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.006 0.0214 0.0336
Giardia lamblia Cathepsin L precursor 0.0017 0.002 0.0126
Brugia malayi follicle stimulating hormone receptor 0.0046 0.015 0.06
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.0167 0.2401
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.002 0.0141
Schistosoma mansoni myosin xvIII 0.0046 0.015 0.0235
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.015 0.0149
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0151 0.015
Brugia malayi GnHR receptor homolog 0.0046 0.015 0.06
Trichomonas vaginalis bollus pemphigoid antigen, putative 0.0015 0.001 0.0085
Echinococcus multilocularis g-protein coupled receptor 0.0046 0.015 0.0149
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 0.0177
Schistosoma mansoni importin beta-1 0.003 0.008 0.0124
Plasmodium vivax vivapain-2 0.0017 0.002 0.0167
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0079 0.0078
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0028 0.0072 0.007
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.002 0.003
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0015 0.0011 0.0015
Giardia lamblia Cathepsin L-like protease 0.0017 0.002 0.0126
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0017 0.002 0.0167
Brugia malayi ecdysteroid receptor 0.0028 0.0072 0.0285
Trypanosoma brucei metacaspase 0.0046 0.0152 0.1839
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0015 0.0009 0.0179
Echinococcus multilocularis G protein coupled receptor 139 0.0046 0.015 0.0149
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0171 0.0684
Brugia malayi nuclear receptor NHR-88 0.0013 0.0004 0.0014
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0021 0.0177
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.0277 0.0276
Echinococcus multilocularis cathepsin L 0.0017 0.002 0.0019
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 0.0177
Echinococcus multilocularis pyruvate kinase 0.007 0.0259 0.0257
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.0075
Trypanosoma brucei centrin-3 0.0023 0.0047 0.0488
Entamoeba histolytica cysteine proteinase 2 0.0017 0.002 0.0462
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.002 0.0177
Echinococcus multilocularis neuropeptide Y receptor 0.0046 0.015 0.0149
Plasmodium falciparum pyruvate kinase 2 0.0036 0.0105 0.1457
Trypanosoma brucei kinesin, putative 0.0047 0.0158 0.1908
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0017 0.002 0.0126
Trichomonas vaginalis caltractin, putative 0.0015 0.001 0.0085
Echinococcus multilocularis snurportin 1 0.0321 0.1398 0.1397
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0188 0.0793 0.1248
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0125 0.051 0.7598
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.002 0.003
Echinococcus multilocularis dro:myosuppressin receptor 0.0046 0.015 0.0149
Entamoeba histolytica cysteine protease, putative 0.0017 0.002 0.0462
Plasmodium vivax vivapain-3 0.0017 0.002 0.0167
Trypanosoma cruzi cysteine proteinase, putative 0.0017 0.002 0.0075
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0044 0.0169
Loa Loa (eye worm) hypothetical protein 0.0037 0.0111 0.0438
Schistosoma mansoni cathepsin B (C01 family) 0.0017 0.002 0.003
Echinococcus granulosus neuropeptides capa receptor 0.0046 0.015 0.0149
Loa Loa (eye worm) DR-78 0.0013 0.0004 0.001
Brugia malayi Thioredoxin reductase 0.0049 0.0167 0.0666
Toxoplasma gondii EF hand domain-containing protein 0.0015 0.001 0.0015
Onchocerca volvulus 0.0015 0.001 0.0057
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Onchocerca volvulus 0.0046 0.015 0.0935
Schistosoma mansoni myosin regulatory light chain 0.0015 0.001 0.0014
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0046 0.015 0.06
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0028 0.0072 0.0441
Giardia lamblia Cysteine protease 0.0017 0.002 0.0126
Loa Loa (eye worm) hypothetical protein 0.0028 0.0072 0.0281
Brugia malayi sulfakinin receptor protein 0.0046 0.015 0.06
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.008 0.0905
Mycobacterium tuberculosis Probable dehydrogenase 0.0113 0.0453 0.8885
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0015 0.0021
Loa Loa (eye worm) hypothetical protein 0.0049 0.0163 0.0647
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.015 0.0149
Trichomonas vaginalis calpain, putative 0.002 0.0035 0.0321
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.002 0.0075
Trypanosoma brucei trypanothione reductase 0.0049 0.0167 0.2024
Trichomonas vaginalis centrin, putative 0.0015 0.001 0.0085
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Onchocerca volvulus 0.0017 0.002 0.0118
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0072 0.0285
Brugia malayi nuclear hormone receptor 0.0013 0.0004 0.0014
Brugia malayi Nuclear hormone receptor E75 0.0013 0.0004 0.0014
Trypanosoma brucei antigen, putative 0.0068 0.025 0.3091
Echinococcus granulosus serotonin receptor 0.0046 0.015 0.0149
Brugia malayi ecdysone receptor 0.0013 0.0004 0.0014
Trypanosoma cruzi kinesin, putative 0.0047 0.0158 0.0625
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0028 0.0072 0.007
Schistosoma mansoni hypothetical protein 0.002 0.0035 0.0054
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0046 0.015 0.0596
Trichomonas vaginalis pyruvate kinase, putative 0.007 0.0259 0.2418
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0017 0.002 0.0177
Entamoeba histolytica cysteine protease, putative 0.0017 0.002 0.0462
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.002 0.0462
Brugia malayi Pyruvate kinase, muscle isozyme 0.007 0.0259 0.1033
Loa Loa (eye worm) hypothetical protein 0.0013 0.0004 0.001
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0157 0.1465
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.015 0.0149
Loa Loa (eye worm) G-protein coupled receptor 0.0046 0.015 0.0596
Brugia malayi Dopamine receptor protein 2 0.0046 0.015 0.06
Toxoplasma gondii cathepsin CPC1 0.0017 0.002 0.0141
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0087 0.0086
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0015 0.0053
Echinococcus multilocularis neuropeptide Y receptor 0.0046 0.015 0.0149
Schistosoma mansoni hypothetical protein 0.0177 0.0744 0.1172
Schistosoma mansoni growth hormone secretagogue receptor 0.0046 0.015 0.0235
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0072 0.0285
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0376 0.3516
Loa Loa (eye worm) myosin Light Chain family member 0.0015 0.001 0.0036
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0046 0.0152 0.1839
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Plasmodium falciparum serine repeat antigen 2 0.0017 0.002 0.0167
Plasmodium falciparum metacaspase 1 0.0046 0.0152 0.2173
Schistosoma mansoni hypothetical protein 0.0321 0.1398 0.2203
Loa Loa (eye worm) Smad1 0.0017 0.0019 0.0071
Echinococcus multilocularis calcyphosin protein 0.0015 0.001 0.0009
Plasmodium vivax calpain, putative 0.0068 0.025 0.3652
Schistosoma mansoni dishevelled 0.0018 0.0025 0.0037
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0565 0.2503 0.3946
Entamoeba histolytica cysteine protease, putative 0.0017 0.002 0.0462
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0167 0.3283
Onchocerca volvulus 0.0046 0.015 0.0935
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0028 0.0072 0.0111
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0035 0.0338
Echinococcus granulosus cathepsin l1 0.0017 0.002 0.0019
Schistosoma mansoni biogenic amine (5HT) receptor 0.0046 0.015 0.0235
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.0143 0.0566
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.002 0.0019
Trypanosoma cruzi metacaspase, putative 0.0046 0.0152 0.0604
Brugia malayi G-protein coupled receptor 0.0046 0.015 0.06
Echinococcus multilocularis serotonin receptor 0.0046 0.015 0.0149
Brugia malayi RasGEF domain containing protein 0.0019 0.003 0.0118
Brugia malayi putative neuropeptide receptor 0.0046 0.015 0.06
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.015 0.0235
Brugia malayi nuclear hormone receptor family member nhr-6 0.0013 0.0004 0.0014
Schistosoma mansoni steroid hormone receptor ad4bp 0.0028 0.0072 0.0111
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.002 0.003
Schistosoma mansoni calmodulin-related 0.0015 0.001 0.0014
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0046 0.015 0.0149
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0015 0.0053
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0046 0.015 0.0935
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 0.0177
Onchocerca volvulus 0.0248 0.1066 0.6677
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0059 0.0636
Schistosoma mansoni neuropeptide receptor 0.0046 0.015 0.0235
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0068 0.025 0.3091
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0059 0.0229
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0072 0.0285
Plasmodium vivax unspecified product 0.0017 0.002 0.0167
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.0211 0.0209
Entamoeba histolytica cysteine protease, putative 0.0017 0.002 0.0462
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0087 0.1003
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0028 0.0072 0.007
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0053
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0196 0.2396
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0167 0.2032
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0188 0.0793 0.0791
Echinococcus multilocularis FTZ F1 alpha 0.0028 0.0072 0.007
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.002 0.008
Schistosoma mansoni biogenic amine receptor 0.0046 0.015 0.0235
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0167 0.4079
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0021 0.0078
Echinococcus granulosus neuropeptides capa receptor 0.0046 0.015 0.0149
Loa Loa (eye worm) hypothetical protein 0.0112 0.0449 0.1791
Giardia lamblia Cathepsin B precursor 0.0017 0.002 0.0126
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.002 0.0141
Schistosoma mansoni hypothetical protein 0.0043 0.0136 0.0212
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0035 0.0137
Loa Loa (eye worm) hypothetical protein 0.003 0.008 0.0313
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.015 0.0149
Schistosoma mansoni smad1 5 8 and 0.0017 0.0019 0.0028
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0054 0.0494
Brugia malayi MH2 domain containing protein 0.0245 0.1054 0.421
Mycobacterium ulcerans pyruvate kinase 0.007 0.0259 0.3785
Schistosoma mansoni acetyl-CoA synthetase 0.0015 0.0009 0.0012
Echinococcus granulosus programmed cell death protein 0.0023 0.0047 0.0046
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0122 0.0496 0.0495
Brugia malayi Steroid receptor seven-up type 2 0.0028 0.0072 0.0285
Onchocerca volvulus 0.0046 0.015 0.0935
Echinococcus granulosus neuropeptide receptor 0.0046 0.015 0.0149
Echinococcus multilocularis Niemann Pick C1 protein 0.0103 0.0409 0.0407
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0044 0.0443
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0046 0.015 0.0596
Schistosoma mansoni Mername-AA248 (C02 family) 0.0068 0.025 0.0392
Leishmania major cathepsin L-like protease 0.0017 0.002 0.0141
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0017 0.002 0.0167
Schistosoma mansoni nuclear hormone receptor 0.0013 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.0075
Brugia malayi hypothetical protein 0.0046 0.015 0.06
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0021 0.0031
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0102 0.1993
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.002 0.0075
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0021 0.0078
Echinococcus granulosus 7tm_1 domain containing protein 0.0046 0.015 0.0149
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0017 0.002 0.003
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Schistosoma mansoni dishevelled 0.0018 0.0025 0.0037
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0046 0.015 0.0149
Brugia malayi jmjC domain containing protein 0.0016 0.0015 0.0057
Brugia malayi hypothetical protein 0.0018 0.0025 0.0098
Entamoeba histolytica cysteine protease, putative 0.0017 0.002 0.0462
Echinococcus granulosus pyruvate kinase 0.0036 0.0105 0.0104
Echinococcus granulosus calpain A 0.0068 0.025 0.0249
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.0039
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0019 0.0018
Plasmodium falciparum thioredoxin reductase 0.0049 0.0167 0.2392
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0009 0.0036
Echinococcus multilocularis neuropeptide receptor 0.0046 0.015 0.0149
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0015 0.0053
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0037 0.0111 0.1542
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0152 0.142
Entamoeba histolytica cysteine protease, putative 0.0017 0.002 0.0462
Brugia malayi calpain 5 0.002 0.0035 0.0141
Echinococcus granulosus caspase 2 0.0089 0.0347 0.0346
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0046 0.015 0.06
Schistosoma mansoni smad 0.0017 0.0019 0.0028
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0035 0.0137
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.0036
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0046 0.015 0.0149
Brugia malayi Cathepsin L-like cysteine proteinase 0.0017 0.002 0.008
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Schistosoma mansoni microtubule-associated protein tau 0.1413 0.634 1
Entamoeba histolytica pyruvate kinase, putative 0.0049 0.0163 0.3976
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.006 0.0214 0.4205
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Brugia malayi Pyruvate kinase, M2 isozyme 0.007 0.0259 0.1033
Schistosoma mansoni amine GPCR 0.0046 0.015 0.0235
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.0075
Echinococcus multilocularis pyruvate kinase 0.0036 0.0105 0.0104
Echinococcus multilocularis segment polarity protein dishevelled 0.0018 0.0025 0.0023
Trypanosoma brucei Calpain-like protein CALP1.3 0.002 0.0035 0.0338
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0152 0.142
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.002 0.003
Echinococcus multilocularis Calcium binding protein 0.0015 0.001 0.0009
Brugia malayi ORL1-like opioid receptor 0.0046 0.015 0.06
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0044 0.0428
Giardia lamblia Hypothetical protein 0.0017 0.002 0.0126
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0015 0.0009 0.0008
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.015 0.0149
Echinococcus multilocularis dnaJ subfamily B 0.0411 0.1802 0.1801
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0087 0.0136
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0017 0.002 0.0075
Onchocerca volvulus 0.0013 0.0004 0.0016
Trichomonas vaginalis ran, putative 0.0022 0.0044 0.0398
Echinococcus multilocularis Myosin regulatory light chain 0.0015 0.001 0.0009
Echinococcus granulosus pyruvate kinase 0.0036 0.0105 0.0104
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0095 0.0376 0.4704
Mycobacterium tuberculosis Probable reductase 0.0113 0.0453 0.8885
Brugia malayi glutathione reductase 0.0049 0.0167 0.0666
Leishmania major cathepsin L-like protease 0.0017 0.002 0.0141
Giardia lamblia Cathepsin L precursor 0.0017 0.002 0.0126
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0068 0.025 0.0994
Schistosoma mansoni hypothetical protein 0.0046 0.015 0.0235
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.002 0.0462
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0017 0.002 0.0167
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0113 0.0453 0.6735
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0035 0.0338
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0035 0.0338
Loa Loa (eye worm) hypothetical protein 0.0365 0.1595 0.6372
Echinococcus granulosus regulator of G protein signaling 7 0.0018 0.0025 0.0023
Toxoplasma gondii thioredoxin reductase 0.0049 0.0167 0.2024
Schistosoma mansoni pyruvate kinase 0.007 0.0259 0.0406
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0028 0.0072 0.0281
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.002 0.0177
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0046 0.015 0.06
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.002 0.0167
Echinococcus multilocularis fmrfamide receptor 0.0046 0.015 0.0149
Schistosoma mansoni cathepsin S (C01 family) 0.0017 0.002 0.003
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0017 0.002 0.0167
Loa Loa (eye worm) hypothetical protein 0.0028 0.0072 0.0281
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.0022 0.0021
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0167 0.3271
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0152 0.142
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.002 0.0177
Loa Loa (eye worm) hypothetical protein 0.0013 0.0004 0.001
Echinococcus multilocularis cpg binding protein 0.003 0.0081 0.008
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0087 0.0136
Brugia malayi orphan nuclear receptor NR2E1 0.0013 0.0004 0.0014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 0.0177
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.0211 0.0209
Onchocerca volvulus 0.0046 0.015 0.0935
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.002 0.0177
Echinococcus granulosus pyruvate kinase 0.007 0.0259 0.0257
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0028 0.0072 0.0285
Trypanosoma cruzi metacaspase, putative 0.0046 0.0152 0.0604
Trypanosoma cruzi pyruvate kinase 2, putative 0.007 0.0259 0.1029
Loa Loa (eye worm) pyruvate kinase 0.007 0.0259 0.1029
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0018 0.0025 0.0037
Schistosoma mansoni thyroid hormone receptor 0.0028 0.0072 0.0111
Echinococcus multilocularis G-protein coupled receptor, putative 0.0046 0.015 0.0149
Loa Loa (eye worm) steroid hormone receptor 0.0028 0.0072 0.0281
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Schistosoma mansoni regulator of G protein signaling 0.0018 0.0025 0.0037
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0013 0.0004 0.0016
Leishmania major metacaspase, putative 0.0046 0.0152 0.1839
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 0.0177
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0049 0.0167 0.2401
Entamoeba histolytica serine/threonine protein kinase, putative 0.0095 0.0376 0.9187
Trypanosoma brucei caltractin, putative 0.0023 0.0047 0.0488
Brugia malayi cathepsin B-like cysteine proteinase 0.0565 0.2503 1
Echinococcus multilocularis hypothetical protein 0.0068 0.025 0.0249
Onchocerca volvulus 0.0046 0.015 0.0935
Loa Loa (eye worm) glutathione reductase 0.0049 0.0167 0.0662
Trypanosoma brucei hypothetical protein 0.002 0.0035 0.0338
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0105 0.0419 0.8207
Brugia malayi hypothetical protein 0.0043 0.0138 0.0551
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0095 0.0376 0.1496
Loa Loa (eye worm) calpain family protein 1 0.0179 0.0756 0.3016
Plasmodium vivax hypothetical protein, conserved 0.0046 0.0152 0.2173
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.002 0.0177
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0019 0.0071
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0565 0.2503 1
Schistosoma mansoni neuropeptide receptor 0.0046 0.015 0.0235
Onchocerca volvulus 0.0046 0.015 0.0935
Loa Loa (eye worm) calpain 5 0.0047 0.0158 0.0625
Schistosoma mansoni hypothetical protein 0.0043 0.0138 0.0216
Loa Loa (eye worm) hypothetical protein 0.0089 0.0347 0.1382
Schistosoma mansoni coup transcription factor 0.0028 0.0072 0.0111
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0015 0.0009 0.0179
Trypanosoma brucei metacaspase MCA3 0.0046 0.0152 0.1839
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0151 0.0236
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0028 0.0072 0.0285
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0214 0.0213
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0035 0.0137
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0017 0.002 0.0167
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 0.0177
Brugia malayi Importin beta-1 subunit 0.003 0.008 0.0317
Echinococcus granulosus tachykinin peptides receptor 99D 0.0046 0.015 0.0149
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0046 0.0152 0.1839
Trypanosoma brucei cysteine peptidase C (CPC) 0.0187 0.0788 1
Toxoplasma gondii hypothetical protein 0.0055 0.0193 0.2362
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0218 0.0342
Brugia malayi AKH receptor 0.0046 0.015 0.06
Trichomonas vaginalis calmodulin, putative 0.0023 0.0047 0.043
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0013 0.0004 0.0016
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0015 0.0011 0.001
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.002 0.0075
Onchocerca volvulus 0.0046 0.015 0.0935
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0017 0.002 0.008
Onchocerca volvulus Myosin regulatory light chain 2 homolog 0.0015 0.001 0.0057
Giardia lamblia Cysteine protease 0.0017 0.002 0.0126
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0035 0.0338
Leishmania major hypothetical protein, conserved 0.0025 0.0059 0.0636
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.0277 0.0435
Loa Loa (eye worm) ctsf protein 0.0017 0.002 0.0075
Loa Loa (eye worm) hypothetical protein 0.0013 0.0004 0.001
Echinococcus multilocularis regulator of G protein signaling 7 0.0018 0.0025 0.0023
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.002 0.0035 0.0338
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0021 0.0149
Onchocerca volvulus 0.0019 0.0027 0.0164
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0013 0.0004 0.0014
Brugia malayi Smad1 0.0017 0.0019 0.0075
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0015 0.0053
Schistosoma mansoni neuropeptide F-like receptor 0.0046 0.015 0.0235
Echinococcus multilocularis nuclear receptor nhr 48 0.0013 0.0004 0.0003
Echinococcus granulosus lysine specific demethylase 5A 0.0061 0.0218 0.0217
Brugia malayi cathepsin F-like cysteine proteinase 0.0017 0.002 0.008
Echinococcus granulosus neuropeptide Y receptor 0.0046 0.015 0.0149
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0072 0.0285
Brugia malayi Muscleblind-like protein 0.0306 0.1328 0.5306
Schistosoma mansoni myosin light chain 0.0015 0.001 0.0014
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.0075
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0059 0.0751
Echinococcus granulosus fmrfamide receptor 0.0046 0.015 0.0149
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0021 0.0039 0.0154
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0046 0.015 0.0235
Schistosoma mansoni patched 1 0.0044 0.0143 0.0224
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.0039
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.002 0.003
Echinococcus granulosus Niemann Pick C1 protein 0.0147 0.0608 0.0607
Echinococcus multilocularis muscleblind protein 0.0306 0.1328 0.1327
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0054 0.0494
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.002 0.0035 0.0137
Schistosoma mansoni nuclear hormone receptor 0.0028 0.0072 0.0111
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.016 0.0668 1
Schistosoma mansoni jumonji domain containing protein 0.0059 0.0211 0.033
Toxoplasma gondii centrin family protein 0.0015 0.001 0.0015
Echinococcus granulosus neuropeptide Y receptor 0.0046 0.015 0.0149
Onchocerca volvulus 0.0046 0.015 0.0935
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 0.0177
Plasmodium falciparum cysteine proteinase falcipain 1 0.0017 0.002 0.0167
Echinococcus granulosus orexin receptor type 2 0.0046 0.015 0.0149
Brugia malayi N-terminal motif family protein 0.0013 0.0001 0.0004
Onchocerca volvulus 0.0046 0.015 0.0935
Echinococcus granulosus nuclear receptor nhr 48 0.0013 0.0004 0.0003
Schistosoma mansoni retinoic acid receptor RXR 0.0028 0.0072 0.0111
Brugia malayi Nuclear hormone receptor E75 0.0013 0.0004 0.0014
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.002 0.0035 0.0338
Echinococcus granulosus Protein patched homolog 1 0.0044 0.0143 0.0142
Onchocerca volvulus 0.0015 0.0009 0.0049
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0187 0.0788 0.3145
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.002 0.0462
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.0009 0.0031
Entamoeba histolytica cysteine protease, putative 0.0017 0.002 0.0462
Brugia malayi calpain 5 0.0047 0.0158 0.0629
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0021 0.0078
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.002 0.0019
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0055 0.0193 0.2791
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0376 0.3516
Trypanosoma cruzi kinesin, putative 0.0047 0.0158 0.0625
Leishmania major calpain protease-like protein 0.002 0.0035 0.0338
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0021 0.0408
Plasmodium vivax JmjC domain containing protein 0.0016 0.0015 0.0083
Echinococcus granulosus snurportin 1 0.0321 0.1398 0.1397
Echinococcus granulosus 7TM GPCR rhodopsin 0.0046 0.015 0.0149
Onchocerca volvulus 0.0028 0.0072 0.0441
Echinococcus multilocularis cathepsin b 0.0565 0.2503 0.2502
Loa Loa (eye worm) hypothetical protein 0.0103 0.0409 0.1628
Brugia malayi calpain 7 0.0068 0.025 0.0997
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0059 0.0229
Brugia malayi hypothetical protein 0.0074 0.0277 0.1105
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.0039
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0049 0.0167 0.3283
Loa Loa (eye worm) hypothetical protein 0.0247 0.1061 0.4236
Echinococcus multilocularis fmrfamide receptor 0.0046 0.015 0.0149
Echinococcus granulosus neuropeptide FF receptor 2 0.0046 0.015 0.0149
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0059 0.0751
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0046 0.015 0.0235
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0196 0.0779
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0013 0.0004 0.0003
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0013 0.0004 0.0004
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0152 0.142
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0009 0.0036
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0015 0.0053
Plasmodium falciparum JmjC domain-containing protein, putative 0.0016 0.0015 0.0083
Echinococcus granulosus tm gpcr rhodopsin 0.0046 0.015 0.0149
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0021 0.0019
Echinococcus granulosus cathepsin b 0.0565 0.2503 0.2502
Loa Loa (eye worm) hypothetical protein 0.0028 0.0072 0.0281
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.016 0.0668 1
Leishmania major cathepsin L-like protease 0.0017 0.002 0.0141
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0013 0.0004 0.0003
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0017 0.002 0.003
Schistosoma mansoni neuropeptide F-like receptor 0.0046 0.015 0.0235
Plasmodium vivax serine-repeat antigen (SERA) 0.0017 0.002 0.0167
Trypanosoma brucei pyruvate kinase 1 0.007 0.0259 0.3203
Brugia malayi RasGEF domain containing protein 0.0013 0.0001 0.0004
Brugia malayi nuclear receptor RXR 0.0015 0.0011 0.0043
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.002 0.0141
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0015 0.0011 0.001
Echinococcus granulosus cathepsin L cysteine protease 0.0017 0.002 0.0019
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.002 0.0141
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.002 0.0177
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0028 0.0072 0.007
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0104 0.0416 0.0654
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0059 0.0751
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.002 0.008
Onchocerca volvulus 0.0017 0.002 0.0118
Loa Loa (eye worm) hypothetical protein 0.0159 0.0664 0.2648
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0035 0.0338
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0015 0.0009 0.0036
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0028 0.0072 0.0111
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0151 0.0599
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0046 0.015 0.0235
Schistosoma mansoni z-protein (S1r protein) 0.0018 0.0025 0.0037
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0068 0.025 0.0994
Loa Loa (eye worm) hypothetical protein 0.0018 0.0025 0.0093
Entamoeba histolytica hypothetical protein 0.0024 0.0054 0.129
Trichomonas vaginalis antibiotic synthetase, putative 0.0015 0.0009 0.0074
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.015 0.0235
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0046 0.015 0.0149
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0028 0.0072 0.0285
Echinococcus granulosus pyruvate kinase 0.0036 0.0105 0.0104
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0017 0.002 0.0177
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.002 0.0019
Echinococcus multilocularis cysteine protease 0.0017 0.002 0.0019
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.015 0.0235
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0046 0.015 0.0235
Loa Loa (eye worm) hypothetical protein 0.0049 0.0167 0.0664
Brugia malayi conserved hypotetical protein 0.0013 0.0004 0.0014
Brugia malayi Pre-SET motif family protein 0.0032 0.0087 0.0348
Plasmodium vivax unspecified product 0.0017 0.002 0.0167
Leishmania major calpain family cysteine protease-like protein 0.002 0.0035 0.0338
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0151 0.0236
Brugia malayi hypothetical protein 0.0046 0.015 0.06
Brugia malayi photoreceptor-specific nuclear receptor 0.0028 0.0072 0.0285
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0046 0.0152 0.0238
Echinococcus granulosus caspase 0.0122 0.0496 0.0495
Loa Loa (eye worm) hypothetical protein 0.0046 0.0152 0.0604
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0021 0.0149
Trypanosoma cruzi metacaspase, putative 0.0046 0.0152 0.0604
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0021 0.0149
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.0211 0.0209
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0152 0.142
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.002 0.0035 0.0338
Schistosoma mansoni nuclear receptor 0.0013 0.0004 0.0004
Brugia malayi cathepsin L-like precursor 0.0017 0.002 0.008
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Trichomonas vaginalis caltractin, putative 0.0015 0.001 0.0085
Toxoplasma gondii cathepsin CPL 0.0017 0.002 0.0141
Onchocerca volvulus Pyruvate kinase homolog 0.007 0.0259 0.1614
Echinococcus multilocularis cathepsin L 0.0017 0.002 0.0019
Onchocerca volvulus 0.0018 0.0025 0.0146
Onchocerca volvulus 0.0015 0.001 0.0057
Trypanosoma brucei calpain-like protein, putative 0.0068 0.025 0.3091
Schistosoma mansoni amine GPCR 0.0046 0.015 0.0235
Brugia malayi Probable ClpP-like protease 0.016 0.0668 0.2669
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0046 0.015 0.0235
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0068 0.025 0.3091
Schistosoma mansoni amine GPCR 0.0046 0.015 0.0235
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0113 0.0453 0.8885
Trypanosoma brucei metacaspase 5, putative 0.0046 0.0152 0.1839
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0376 0.3516
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0218 0.093 0.3712
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0015 0.0009 0.0179
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.015 0.0149
Toxoplasma gondii cathepsin B 0.0187 0.0788 1
Leishmania major cathepsin L-like protease 0.0017 0.002 0.0141
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0068 0.025 0.3091
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0017 0.002 0.003
Loa Loa (eye worm) calpain family protein 1 0.0132 0.0541 0.216
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0068 0.025 0.0994
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0167 0.2032
Plasmodium vivax vivapain-1 0.0017 0.002 0.0167
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.002 0.0462
Brugia malayi Cathepsin L-like precursor 0.0017 0.002 0.008
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.002 0.0075
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0072 0.0285
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.002 0.0141
Brugia malayi hypothetical protein 0.0013 0.0004 0.0014
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0122 0.0496 0.0495
Trypanosoma brucei calpain-like protein, putative 0.0068 0.025 0.3091
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0053
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0044 0.0042
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0021 0.0149
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0028 0.0072 0.0281
Schistosoma mansoni calpain (C02 family) 0.0068 0.025 0.0392
Entamoeba histolytica cysteine protease, putative 0.0017 0.002 0.0462
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0046 0.0152 0.0608
Echinococcus granulosus peptide allatostatin:somatostatin 0.0046 0.015 0.0149
Brugia malayi Cathepsin L-like precursor 0.0017 0.002 0.008
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0017 0.002 0.003
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0035 0.0137
Giardia lamblia Pyruvate kinase 0.007 0.0259 0.3193
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0021 0.0149
Loa Loa (eye worm) hypothetical protein 0.0306 0.1328 0.5304
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0167 0.2401
Plasmodium falciparum serine repeat antigen 4 0.0017 0.002 0.0167
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0021 0.0078
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0021 0.0177
Loa Loa (eye worm) pyruvate kinase 0.0015 0.001 0.0034
Plasmodium vivax pyruvate kinase 2, putative 0.0036 0.0105 0.1457
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.0075
Brugia malayi jmjC domain containing protein 0.0059 0.0211 0.0841
Trypanosoma brucei calpain-like protein, putative 0.0068 0.025 0.3091
Schistosoma mansoni alpha-1 adrenergic receptor 0.0046 0.015 0.0235
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.002 0.0177
Giardia lamblia Hypothetical protein 0.0017 0.002 0.0126
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0028 0.0072 0.0285
Trichomonas vaginalis pyruvate kinase, putative 0.007 0.0259 0.2418
Plasmodium vivax glutathione reductase, putative 0.0049 0.0167 0.2392
Brugia malayi MH1 domain containing protein 0.0017 0.0019 0.0075
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.002 0.0141
Brugia malayi Cathepsin L-like precursor 0.0017 0.002 0.008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 0.0177
Brugia malayi hypothetical protein 0.0018 0.0025 0.0098
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0015 0.0021
Trypanosoma cruzi cruzipain precursor, putative 0.0017 0.002 0.0075
Brugia malayi hypothetical protein 0.0046 0.015 0.06
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0152 0.142
Entamoeba histolytica cysteine protease, putative 0.0017 0.002 0.0462
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.002 0.0141
Onchocerca volvulus 0.0015 0.0009 0.0049
Plasmodium falciparum serine repeat antigen 8 0.0017 0.002 0.0167
Brugia malayi Cell death protein 3 precursor 0.0089 0.0347 0.1386
Plasmodium vivax myosin A tail domain interacting protein MTIP, putative 0.0015 0.001 0.0018
Schistosoma mansoni biogenic amine (5HT) receptor 0.0046 0.015 0.0235
Echinococcus granulosus phd:f box containing protein 0.0016 0.0015 0.0013
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.002 0.003
Schistosoma mansoni opsin-like receptor 0.0046 0.015 0.0235
Echinococcus granulosus alpha 1A adrenergic receptor 0.0046 0.015 0.0149
Schistosoma mansoni myosin regulatory light chain 0.0015 0.001 0.0014
Plasmodium vivax serine-repeat antigen (SERA) 0.0017 0.002 0.0167
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0046 0.015 0.0596
Onchocerca volvulus Cathepsin F homolog 0.0017 0.002 0.0118
Echinococcus multilocularis programmed cell death protein 0.0023 0.0047 0.0046
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0035 0.0137
Giardia lamblia Cathepsin L precursor 0.0017 0.002 0.0126
Loa Loa (eye worm) hypothetical protein 0.0013 0.0004 0.001
Plasmodium falciparum centrin-4 0.0015 0.001 0.0018
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.016 0.0668 0.0667
Schistosoma mansoni peptidase Clp (S14 family) 0.016 0.0668 0.1052
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0046 0.015 0.0149
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0035 0.0338
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0015 0.0009 0.0192
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.015 0.0235
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0035 0.0338
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0044 0.0523
Trypanosoma brucei Calpain-like protein 1.1 0.002 0.0035 0.0338
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.002 0.0035 0.0137
Onchocerca volvulus 0.0015 0.0009 0.0049
Echinococcus multilocularis pyruvate kinase 0.0036 0.0105 0.0104
Echinococcus granulosus pyruvate kinase 0.007 0.0259 0.0257
Loa Loa (eye worm) oxidoreductase 0.0015 0.0009 0.0031
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0017 0.002 0.0167
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0015 0.0013
Entamoeba histolytica protein kinase, putative 0.0048 0.0159 0.3874
Loa Loa (eye worm) hypothetical protein 0.0013 0.0004 0.001
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0068 0.025 0.0994
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0017 0.002 0.0126
Loa Loa (eye worm) hypothetical protein 0.016 0.0668 0.2666
Giardia lamblia Cathepsin B precursor 0.0187 0.0788 1
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0015 0.0009 0.0179
Loa Loa (eye worm) DIX domain-containing protein 0.0018 0.0025 0.0093
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.002 0.0019
Brugia malayi cathepsin Z-like cysteine proteinase 0.0017 0.002 0.008
Echinococcus multilocularis neuropeptide receptor 0.0046 0.015 0.0149
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.015 0.0235
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.002 0.0035 0.0321
Loa Loa (eye worm) hypothetical protein 0.0032 0.0087 0.0344
Giardia lamblia Kinase, PLK 0.0095 0.0376 0.4696
Entamoeba histolytica grainin 2 0.0015 0.001 0.0222
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Onchocerca volvulus 0.0046 0.015 0.0935
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0021 0.0183
Loa Loa (eye worm) hypothetical protein 0.0028 0.0072 0.0281
Trichomonas vaginalis centrin, putative 0.0015 0.001 0.0085
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 0.0177
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.016 0.0668 1
Entamoeba histolytica cysteine protease, putative 0.0017 0.002 0.0462
Loa Loa (eye worm) hypothetical protein 0.0044 0.0143 0.0566
Plasmodium falciparum metacaspase-like protein 0.0046 0.0152 0.2173
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0167 0.0662
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0021 0.0019
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0218 0.0866
Schistosoma mansoni hypothetical protein 0.0043 0.0136 0.0212
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0017 0.002 0.003
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.016 0.0668 1
Entamoeba histolytica cysteine protease, putative 0.0017 0.002 0.0462
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0028 0.0072 0.0281
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0019 0.0018
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.016 0.0668 1
Schistosoma mansoni cathepsin C 0.0017 0.002 0.003
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0015 0.0013
Brugia malayi calpain family protein 1 0.0179 0.0756 0.3019
Trypanosoma cruzi pyruvate kinase 2, putative 0.007 0.0259 0.1029
Mycobacterium tuberculosis Probable oxidoreductase 0.0125 0.051 1
Echinococcus multilocularis calpain A 0.0188 0.0793 0.0791
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 0.0177
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0068 0.025 0.0994
Brugia malayi hypothetical protein 0.0247 0.1061 0.4238
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0009 0.0036
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0167 0.2392
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0021 0.0149
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0151 0.0236
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 0.0177
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0565 0.2503 0.3946
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0046 0.015 0.0235
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.0031
Loa Loa (eye worm) melatonin receptor type 1A 0.0046 0.015 0.0596
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0179 0.0756 0.119
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.002 0.0035 0.0321
Brugia malayi Probable myosin regulatory light chain 0.0015 0.001 0.004
Brugia malayi Myosin regulatory light chain 1 0.0015 0.001 0.004
Brugia malayi hypothetical protein 0.0015 0.0011 0.0043
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0068 0.025 0.0994
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0015 0.007
Schistosoma mansoni dep domain containing protein 0.0018 0.0025 0.0037
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.002 0.0035 0.0137
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.002 0.0177
Echinococcus multilocularis caspase 3 0.0076 0.0287 0.0286
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.002 0.0075
Entamoeba histolytica calmodulin, putative 0.0015 0.001 0.0222
Loa Loa (eye worm) neuropeptide F receptor 0.0046 0.015 0.0596
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0015 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0187 0.0788 0.7391
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0376 0.3516
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0167 0.0668
Brugia malayi Cathepsin L-like precursor 0.0017 0.002 0.008
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0019 0.0071
Schistosoma mansoni smad1 5 8 and 0.0017 0.0019 0.0028
Plasmodium falciparum serine repeat antigen 9 0.0017 0.002 0.0167
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0028 0.0072 0.007
Onchocerca volvulus Neuropeptide F receptor homolog 0.0046 0.015 0.0935
Plasmodium vivax pyruvate kinase, putative 0.007 0.0259 0.3785
Echinococcus multilocularis orexin receptor type 2 0.0046 0.015 0.0149
Leishmania major cathepsin L-like protease 0.0017 0.002 0.0141
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0019 0.0018
Echinococcus multilocularis calpain 0.0068 0.025 0.0249
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0214 0.0213
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0015 0.0009 0.0031
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0013 0.0004 0.0003
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0365 0.1595 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Trypanosoma cruzi cysteine protease, putative 0.0017 0.002 0.0075
Loa Loa (eye worm) hypothetical protein 0.0018 0.0025 0.0093
Brugia malayi Cathepsin L-like precursor 0.0017 0.002 0.008
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0113 0.0453 0.8885
Brugia malayi Cathepsin L-like precursor 0.0017 0.002 0.008
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0046 0.015 0.0149
Echinococcus granulosus neuropeptide receptor 0.0046 0.015 0.0149
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0046 0.015 0.0149
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0151 0.015
Brugia malayi hypothetical protein 0.0046 0.015 0.06
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.016 0.0668 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.0075
Onchocerca volvulus Bile acid receptor homolog 0.0028 0.0072 0.0441
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.0277 0.0276
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0021 0.0078
Echinococcus granulosus Calcium binding protein 0.0015 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Schistosoma mansoni hypothetical protein 0.0043 0.0136 0.0212
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0167 0.2401
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0037 0.0111 0.139
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 0.0177
Echinococcus granulosus Myosin regulatory light chain 0.0015 0.001 0.0009
Plasmodium falciparum serine repeat antigen 7 0.0017 0.002 0.0167
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0068 0.025 0.0994
Loa Loa (eye worm) hypothetical protein 0.007 0.0259 0.1029
Schistosoma mansoni opsin-like receptor 0.0046 0.015 0.0235
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0072 0.007
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.0036
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0046 0.015 0.0235
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0035 0.0137
Echinococcus granulosus g protein coupled receptor 0.0046 0.015 0.0149
Echinococcus granulosus neuropeptide s receptor 0.0046 0.015 0.0149
Brugia malayi hypothetical protein 0.0046 0.015 0.06
Brugia malayi hypothetical protein 0.0013 0.0004 0.0014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0028 0.0072 0.0281
Giardia lamblia Cathepsin L precursor 0.0017 0.002 0.0126
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0046 0.015 0.0149
Brugia malayi Dopamine receptor protein 1 0.0046 0.015 0.06
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0125 0.051 1
Trypanosoma cruzi metacaspase 5, putative 0.0046 0.0152 0.0604
Echinococcus multilocularis neuropeptide s receptor 0.0046 0.015 0.0149
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0046 0.015 0.0149
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0167 0.0166
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0152 0.142
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0046 0.015 0.0149
Trypanosoma cruzi calpain cysteine peptidase, putative 0.002 0.0035 0.0137
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0087 0.0086
Toxoplasma gondii pyruvate kinase PyK1 0.007 0.0259 0.3203
Echinococcus multilocularis calpain 7 (C02 family) 0.0068 0.025 0.0249
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0035 0.0338
Brugia malayi calpain D 0.002 0.0035 0.0141
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0087 0.0136
Brugia malayi G protein-coupled receptor F59B2.13 0.0046 0.015 0.06
Echinococcus multilocularis ecdysone induced protein 78C 0.0028 0.0072 0.007
Toxoplasma gondii calcium binding protein precursor, putative 0.0015 0.001 0.0015
Echinococcus multilocularis regulator of G protein signaling 7 0.0018 0.0025 0.0023
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0046 0.015 0.0149
Loa Loa (eye worm) neuropeptide F receptor 0.0046 0.015 0.0596
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0046 0.015 0.0596
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.0009 0.0031
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.015 0.0149
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0021 0.0078
Brugia malayi pyruvate kinase, muscle isozyme 0.0015 0.001 0.0038
Onchocerca volvulus Pyruvate kinase homolog 0.007 0.0259 0.1614
Echinococcus multilocularis caspase 8 0.0046 0.0152 0.0151
Echinococcus multilocularis protein patched 0.0044 0.0143 0.0142
Brugia malayi jmjC domain containing protein 0.0016 0.0015 0.0057
Echinococcus granulosus dnaJ subfamily B 0.0411 0.1802 0.1801
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 0.0177
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 0.0177
Trichomonas vaginalis centrin, putative 0.0015 0.001 0.0085
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0021 0.0082
Loa Loa (eye worm) hypothetical protein 0.0049 0.0167 0.0664
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 0.0177
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0113 0.0453 0.8885
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0046 0.015 0.0235
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.002 0.008
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0044 0.0169
Plasmodium falciparum calpain 0.002 0.0035 0.04
Trypanosoma brucei cysteine peptidase, putative 0.002 0.0035 0.0338
Echinococcus granulosus microtubule associated protein 2 0.1413 0.634 0.634
Schistosoma mansoni neuropeptide receptor 0.0046 0.015 0.0235
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0028 0.0072 0.0111
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0035 0.0338
Trichomonas vaginalis calcium binding protein, putative 0.0023 0.0047 0.043
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0072 0.007
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0017 0.002 0.003
Onchocerca volvulus 0.0046 0.015 0.0935
Loa Loa (eye worm) calpain 0.0068 0.025 0.0994
Echinococcus multilocularis pyruvate kinase 0.007 0.0259 0.0257
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0095 0.0376 0.0374
Plasmodium vivax vivapain-2 0.0017 0.002 0.0167
Schistosoma mansoni nuclear hormone receptor 0.0013 0.0004 0.0004
Leishmania major GTP-binding protein, putative 0.0022 0.0044 0.0443
Entamoeba histolytica calpain family cysteine protease, putative 0.002 0.0035 0.0839
Brugia malayi CHE-14 protein 0.0044 0.0143 0.0571
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.015 0.0149
Brugia malayi MH1 domain containing protein 0.0017 0.0019 0.0075
Schistosoma mansoni pyruvate kinase 0.0036 0.0105 0.0164
Echinococcus multilocularis neuropeptides capa receptor 0.0046 0.015 0.0149
Brugia malayi steroid hormone receptor 0.0028 0.0072 0.0285
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0046 0.015 0.0149
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0021 0.0078
Entamoeba histolytica hypothetical protein 0.0074 0.0277 0.6765
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.015 0.0149
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0102 0.1993
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0009 0.0031
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0152 0.142
Loa Loa (eye worm) hypothetical protein 0.0083 0.0319 0.1269
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0103 0.0409 1
Toxoplasma gondii pyruvate kinase PyKII 0.0036 0.0105 0.1233
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.0039
Loa Loa (eye worm) hypothetical protein 0.0132 0.0541 0.216
Trypanosoma brucei metacaspase MCA2 0.0046 0.0152 0.1839
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0152 0.142
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Echinococcus granulosus calpain A 0.0188 0.0793 0.0791
Echinococcus multilocularis thyroid hormone receptor alpha 0.0028 0.0072 0.007
Loa Loa (eye worm) pyruvate kinase 0.007 0.0259 0.1029
Echinococcus granulosus neuropeptide receptor A26 0.0046 0.015 0.0149
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0028 0.0072 0.007
Brugia malayi nuclear receptor RXR 0.0013 0.0004 0.0014
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0017 0.002 0.003
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0028 0.0072 0.0111
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0376 0.3516
Brugia malayi Nuclear hormone receptor-like 1 0.0015 0.0011 0.0043
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.0376 0.059
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0046 0.015 0.0149
Brugia malayi nuclear receptor NHR-88 0.0028 0.0072 0.0285
Brugia malayi hypothetical protein 0.0016 0.0018 0.007
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0017 0.002 0.0177
Loa Loa (eye worm) cysteine protease 0.0017 0.002 0.0075
Echinococcus granulosus biogenic amine 5HT receptor 0.0046 0.015 0.0149
Trypanosoma brucei Calpain-like protein 1.2 0.002 0.0035 0.0338
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0152 0.142
Brugia malayi Serotonin receptor 0.0046 0.015 0.06
Schistosoma mansoni hypothetical protein 0.0046 0.015 0.0235
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.002 0.0141
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0046 0.015 0.0235
Onchocerca volvulus Pyruvate kinase homolog 0.007 0.0259 0.1614
Echinococcus multilocularis protein dispatched 1 0.005 0.0171 0.017
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0083 0.0319 0.7791
Brugia malayi jmjC domain containing protein 0.0016 0.0015 0.0057
Echinococcus multilocularis programmed cell death protein 6 0.0015 0.001 0.0009
Entamoeba histolytica hypothetical protein 0.0074 0.0277 0.6765
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0035 0.0137
Trypanosoma cruzi major cysteine proteinase, putative 0.0017 0.002 0.0075
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0015 0.0013
Schistosoma mansoni biogenic amine receptor 0.0046 0.015 0.0235
Plasmodium falciparum serine repeat antigen 6 0.0017 0.002 0.0167
Brugia malayi G-protein coupled receptor 0.0046 0.015 0.06
Brugia malayi Tachykinin-like peptides receptor 99D 0.0046 0.015 0.06
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0035 0.0338
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0015 0.0021
Schistosoma mansoni ran 0.0022 0.0044 0.0067
Onchocerca volvulus 0.0017 0.002 0.0118
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0017 0.002 0.0177
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0044 0.0042
Brugia malayi hypothetical protein 0.0046 0.015 0.06
Leishmania major importin beta-1 subunit, putative 0.0024 0.0054 0.0574
Giardia lamblia Cathepsin L precursor 0.0017 0.002 0.0126
Echinococcus granulosus g protein coupled receptor 0.0046 0.015 0.0149
Onchocerca volvulus 0.0158 0.0657 0.4117
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0214 0.3115
Trypanosoma brucei polo-like protein kinase 0.0095 0.0376 0.4704
Echinococcus multilocularis g protein coupled receptor 0.0046 0.015 0.0149
Brugia malayi Pre-SET motif family protein 0.0218 0.093 0.3714
Onchocerca volvulus 0.0112 0.0449 0.2811
Trichomonas vaginalis calpain, putative 0.002 0.0035 0.0321
Trypanosoma cruzi centrin, putative 0.0023 0.0047 0.0183
Giardia lamblia Cathepsin B precursor 0.0017 0.002 0.0126
Echinococcus granulosus caspase 3 0.0076 0.0287 0.0286
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0035 0.0137
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0015 0.007
Brugia malayi RasGEF domain containing protein 0.0013 0.0001 0.0004
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Echinococcus granulosus Nuclear hormone receptor HR96 0.0013 0.0004 0.0003
Echinococcus multilocularis neuropeptide FF receptor 2 0.0046 0.015 0.0149
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.002 0.0075
Onchocerca volvulus 0.0029 0.0074 0.0455
Echinococcus granulosus segment polarity protein dishevelled 0.0018 0.0025 0.0023
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0046 0.015 0.0596
Echinococcus granulosus sex peptide receptor 0.0046 0.015 0.0149
Brugia malayi cathepsin Z-like cysteine proteinase 0.0017 0.002 0.008
Giardia lamblia Pyruvate kinase 0.0036 0.0105 0.122
Brugia malayi G protein-coupled receptor 0.0046 0.015 0.06
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0151 0.015
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0017 0.002 0.0462
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0017 0.002 0.0167
Leishmania major cysteine peptidase A (CPA) 0.0017 0.002 0.0141
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0009 0.0179
Echinococcus multilocularis pyruvate kinase 0.0055 0.0192 0.0191
Onchocerca volvulus 0.005 0.0171 0.1066
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0049 0.0167 0.2401
Echinococcus multilocularis segment polarity protein dishevelled 0.0018 0.0025 0.0023
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0037 0.0111 0.2172
Toxoplasma gondii calmodulin, putative 0.0015 0.001 0.0015
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0035 0.0137
Leishmania major cathepsin L-like protease 0.0017 0.002 0.0141
Schistosoma mansoni calpain-2 (C02 family) 0.002 0.0035 0.0054
Loa Loa (eye worm) hypothetical protein 0.0025 0.0059 0.0229
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0072 0.0285
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 0.0177
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0035 0.0338
Loa Loa (eye worm) hypothetical protein 0.0054 0.0188 0.0746
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0074 0.029
Echinococcus multilocularis Smad4 0.0017 0.0019 0.0018
Brugia malayi cathepsin L precursor 0.0017 0.002 0.008
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0017 0.002 0.003
Loa Loa (eye worm) hypothetical protein 0.0179 0.0756 0.3016
Schistosoma mansoni caspase-7 (C14 family) 0.0122 0.0496 0.0781
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0188 0.0793 0.1248
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.016 0.0668 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0087 0.0136
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0018 0.0025 0.0098
Schistosoma mansoni hypothetical protein 0.0046 0.015 0.0235
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0017 0.002 0.0177
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0054 0.0494
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0046 0.015 0.0149
Loa Loa (eye worm) hypothetical protein 0.0028 0.0072 0.0281
Plasmodium falciparum glutathione reductase 0.0049 0.0167 0.2392
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0046 0.015 0.06
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Leishmania major trypanothione reductase 0.0049 0.0167 0.2024
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.002 0.0141
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0053
Brugia malayi hypothetical protein 0.0046 0.015 0.06
Loa Loa (eye worm) pyruvate kinase-PB 0.0049 0.0163 0.0647
Echinococcus multilocularis geminin 0.0177 0.0744 0.0743
Leishmania major cathepsin L-like protease 0.0017 0.002 0.0141
Schistosoma mansoni survival motor neuron protein 0.005 0.0171 0.0268
Echinococcus granulosus importin subunit beta 1 0.003 0.008 0.0078
Schistosoma mansoni calpain-7 (C02 family) 0.0068 0.025 0.0392
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0046 0.015 0.0235
Schistosoma mansoni cpg binding protein 0.003 0.0081 0.0126
Echinococcus multilocularis expressed conserved protein 0.0097 0.038 0.0379
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0095 0.0376 0.0374
Echinococcus granulosus hypothetical protein 0.0046 0.015 0.0149
Loa Loa (eye worm) hypothetical protein 0.0565 0.2503 1
Trichomonas vaginalis set domain proteins, putative 0.0248 0.1066 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0113 0.0453 0.8885
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.002 0.0035 0.0338
Trypanosoma cruzi cysteine proteinase, putative 0.0017 0.002 0.0075
Echinococcus multilocularis calpain family protein 1, d 0.0132 0.0541 0.054
Entamoeba histolytica hypothetical protein 0.0074 0.0277 0.6765
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0015 0.0009 0.0008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.002 0.0141
Echinococcus granulosus calpain 7 C02 family 0.0068 0.025 0.0249
Loa Loa (eye worm) nuclear hormone receptor 0.0013 0.0004 0.001
Schistosoma mansoni neuropeptide f receptor 76f 0.0046 0.015 0.0235
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0214 0.3115
Loa Loa (eye worm) hypothetical protein 0.0013 0.0004 0.001
Onchocerca volvulus Cathepsin L homolog 0.0017 0.002 0.0118
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0015 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0028 0.0072 0.0285
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0376 0.3516
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0055 0.0193 0.2791
Brugia malayi nuclear hormone receptor family member odr-7 0.0013 0.0004 0.0014
Loa Loa (eye worm) hypothetical protein 0.0018 0.0025 0.0093
Trypanosoma brucei calpain, putative 0.002 0.0035 0.0338
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0017 0.002 0.0126
Schistosoma mansoni calpain C (C02 family) 0.0068 0.025 0.0392
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.2221 1 1
Trypanosoma cruzi metacaspase 5, putative 0.0046 0.0152 0.0604
Echinococcus multilocularis g protein coupled receptor 0.0046 0.015 0.0149
Echinococcus granulosus apoptotic protease activating factor 1 0.0043 0.0138 0.0137
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0015 0.007
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.002 0.0035 0.0321
Plasmodium falciparum importin beta, putative 0.003 0.008 0.1069
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0035 0.0137
Echinococcus granulosus muscleblind protein 0.0306 0.1328 0.1327
Trichomonas vaginalis calcium binding protein, putative 0.0015 0.001 0.0085
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.002 0.0075
Entamoeba histolytica cysteine protease, putative 0.0017 0.002 0.0462
Entamoeba histolytica grainin 2 0.0023 0.0047 0.1125
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.002 0.0167
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0018 0.0025 0.0146
Loa Loa (eye worm) hypothetical protein 0.0013 0.0004 0.001
Echinococcus granulosus calpain 0.0068 0.025 0.0249
Onchocerca volvulus Serine\/threonine kinase homolog 0.0095 0.0376 0.2348
Entamoeba histolytica cysteine protease, putative 0.0017 0.002 0.0462
Brugia malayi Neuronal calcium sensor family protein 1 0.0015 0.001 0.004
Plasmodium falciparum thioredoxin reductase 0.0017 0.0021 0.0177
Onchocerca volvulus 0.0043 0.0138 0.0858
Echinococcus multilocularis sex peptide receptor 0.0046 0.015 0.0149
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.008 0.0905
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Trichomonas vaginalis hypothetical protein 0.002 0.0035 0.0321
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0017 0.002 0.0167
Onchocerca volvulus 0.0017 0.002 0.0118
Brugia malayi Melatonin receptor type 1A 0.0046 0.015 0.06
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Entamoeba histolytica acyl-coA synthetase, putative 0.0049 0.0167 0.4079
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0225 0.0353
Brugia malayi Cathepsin L-like precursor 0.0017 0.002 0.008
Leishmania major hypothetical protein, unknown function 0.002 0.0035 0.0338
Schistosoma mansoni pyruvate kinase 0.007 0.0259 0.0406
Brugia malayi Serotonin receptor 0.0046 0.015 0.06
Plasmodium falciparum pyruvate kinase 0.007 0.0259 0.3785
Echinococcus granulosus Pleckstrin G protein interacting region 0.0018 0.0025 0.0023
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.0031
Echinococcus granulosus cathepsin l1 0.0017 0.002 0.0019
Loa Loa (eye worm) TYRA-2 protein 0.0046 0.015 0.0596
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0018 0.0025 0.0093
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.015 0.0149
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0055 0.0193 0.2661
Brugia malayi jmjC domain containing protein 0.0061 0.0218 0.087
Entamoeba histolytica Ran family GTPase 0.0022 0.0044 0.1039
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0035 0.0321
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.015 0.0149
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0028 0.0072 0.0111
Echinococcus granulosus survival motor neuron protein 1 0.0247 0.1061 0.106
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0009 0.0179
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 0.0177
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0083 0.0319 0.7791
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0021 0.0177
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0015 0.0009 0.0179
Plasmodium falciparum serine repeat antigen 1 0.0017 0.002 0.0167
Echinococcus granulosus G protein coupled receptor 139 0.0046 0.015 0.0149
Echinococcus multilocularis peptidase Clp (S14 family) 0.0105 0.0419 0.0417
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.0036
Schistosoma mansoni kinase 0.0049 0.0163 0.0255
Onchocerca volvulus 0.0017 0.002 0.0118
Giardia lamblia Cathepsin L precursor 0.0017 0.002 0.0126
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0046 0.015 0.06
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0218 0.0342
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.002 0.0177
Trypanosoma brucei calpain-like protein, putative 0.0068 0.025 0.3091
Echinococcus multilocularis apoptotic protease activating factor 1 0.0043 0.0138 0.0137
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0565 0.2503 0.3946
Schistosoma mansoni biogenic amine receptor 0.0046 0.015 0.0235
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.015 0.0149
Schistosoma mansoni hypothetical protein 0.0074 0.0277 0.0435
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.002 0.0141
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.002 0.0035 0.0338
Onchocerca volvulus 0.0017 0.002 0.0118
Trypanosoma cruzi metacaspase, putative 0.0046 0.0152 0.0604
Loa Loa (eye worm) hypothetical protein 0.0037 0.0111 0.0438
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0044 0.0173
Echinococcus multilocularis neuropeptide receptor A26 0.0046 0.015 0.0149
Brugia malayi larval opioid receptor 0.0046 0.015 0.06
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0167 0.0166
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0015 0.0011 0.0015
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.016 0.0668 0.0667
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0143 0.1331
Loa Loa (eye worm) hypothetical protein 0.0306 0.1328 0.5304
Schistosoma mansoni neuropeptide receptor 0.0046 0.015 0.0235
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Onchocerca volvulus 0.0046 0.015 0.0935
Echinococcus multilocularis allatostatin A receptor 0.0046 0.015 0.0149
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0046 0.015 0.0149
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.0021 0.0134
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0013 0.0004 0.0004
Echinococcus granulosus cysteine protease 0.0017 0.002 0.0019
Loa Loa (eye worm) hypothetical protein 0.0013 0.0004 0.001
Brugia malayi nuclear hormone receptor 0.0028 0.0072 0.0285
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0152 0.142
Schistosoma mansoni hypothetical protein 0.0177 0.0744 0.1172
Giardia lamblia Cysteine protease 0.0017 0.002 0.0126

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) 0 Maximum contractile response of thoracic aorta in albino Wistar rat after 30 min ChEMBL. 16279788
Kd (functional) = 8 Antagonist activity at rat UT receptor ChEMBL. 16279788
Ki (binding) = -7.9 Displacement of [125I]urotensin 2 from human UT receptor expressed in CHO-K1 cells ChEMBL. 16279788
Log Ki (binding) = 7.9 Displacement of [125I]urotensin 2 from human UT receptor expressed in CHO-K1 cells ChEMBL. 16279788
pA2 (functional) = 8 Antagonist activity at rat UT receptor ChEMBL. 16279788

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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