Detailed information for compound 442855

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 471.634 | Formula: C30H37N3O2
  • H donors: 0 H acceptors: 2 LogP: 6.21 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[C@H]1OC(=O)[C@H]2[C@@H]1[C@@H](/C=C/c1ccc(cn1)N1CCN(CC1)c1ccccc1)[C@H]1[C@H](C2)CCCC1
  • InChi: 1S/C30H37N3O2/c1-21-29-27(26-10-6-5-7-22(26)19-28(29)30(34)35-21)14-12-23-11-13-25(20-31-23)33-17-15-32(16-18-33)24-8-3-2-4-9-24/h2-4,8-9,11-14,20-22,26-29H,5-7,10,15-19H2,1H3/b14-12+/t21-,22+,26-,27+,28-,29+/m1/s1
  • InChiKey: DPFTURWFPGEFQJ-WTEZSIDUSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens coagulation factor II (thrombin) receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.1367 0.4188 0.4382
Echinococcus granulosus mitogen activated protein kinase 14 0.0477 0.1025 0.1018
Brugia malayi Protein kinase domain containing protein 0.0223 0.0123 0.0129
Loa Loa (eye worm) hypothetical protein 0.027 0.029 0.0304
Loa Loa (eye worm) hypothetical protein 0.0269 0.0286 0.03
Echinococcus multilocularis dual specificity protein kinase clk2 0.0461 0.0967 0.1005
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0654 0.1654 0.1725
Trichomonas vaginalis AGC family protein kinase 0.0854 0.2366 0.8739
Schistosoma mansoni protein kinase 0.0577 0.1379 0.1437
Echinococcus multilocularis tyrosine protein kinase Abl 0.0628 0.1563 0.1629
Echinococcus multilocularis epidermal growth factor receptor 0.1798 0.572 0.5983
Brugia malayi serine/threonine protein kinase 6 0.0949 0.2704 0.2829
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0404 0.0766 0.0795
Schistosoma mansoni serine/threonine protein kinase 0.0247 0.0207 0.0209
Loa Loa (eye worm) TK/ABL protein kinase 0.0897 0.2518 0.2635
Brugia malayi hypothetical protein 0.0283 0.0334 0.035
Echinococcus granulosus Vam6:Vps39 protein 0.0331 0.0506 0.0499
Schistosoma mansoni serine/threonine protein kinase 0.0257 0.0243 0.0246
Onchocerca volvulus 0.0327 0.0493 0.1506
Echinococcus granulosus tyrosine protein kinase Btk29A 0.1184 0.3537 0.3532
Leishmania major protein kinase, putative 0.0256 0.024 0.04
Leishmania major protein kinase, putative 0.0461 0.0967 0.3231
Loa Loa (eye worm) AGC/NDR protein kinase 0.0461 0.097 0.1015
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.034 0.0539 0.1565
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0461 0.0967 0.1012
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0331 0.0506 0.0522
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0223 0.0123 0.0129
Schistosoma mansoni serine/threonine protein kinase 0.0417 0.0812 0.0843
Loa Loa (eye worm) hypothetical protein 0.1057 0.3087 0.323
Loa Loa (eye worm) thyroid receptor interactor 0.0336 0.0522 0.0546
Brugia malayi Variant SH3 domain containing protein 0.0269 0.0286 0.03
Trypanosoma brucei Casein kinase II 0.0302 0.0403 0.1035
Entamoeba histolytica protein kinase domain containing protein 0.0293 0.0373 0.1075
Schistosoma mansoni serine/threonine protein kinase 0.0435 0.0874 0.0908
Loa Loa (eye worm) camk/dcamkl protein kinase 0.0452 0.0937 0.0981
Brugia malayi Protein kinase c protein 2 0.0348 0.0567 0.0594
Loa Loa (eye worm) AGC/PKN protein kinase 0.0846 0.2335 0.2443
Echinococcus granulosus serine:threonine protein kinase 3 0.0766 0.2053 0.2048
Schistosoma mansoni serine/threonine protein kinase 0.0254 0.0231 0.0234
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0357 0.06 0.1802
Trichomonas vaginalis CMGC family protein kinase 0.0417 0.0812 0.2936
Echinococcus granulosus protein kinase 0.0459 0.0962 0.0955
Loa Loa (eye worm) TK/FER protein kinase 0.0283 0.0334 0.035
Loa Loa (eye worm) hypothetical protein 0.0359 0.0606 0.0634
Echinococcus multilocularis serine threonine protein kinase 0.0583 0.1401 0.1459
Loa Loa (eye worm) hypothetical protein 0.071 0.1854 0.194
Trichomonas vaginalis AGC family protein kinase 0.0409 0.0783 0.2825
Brugia malayi ephrin receptor 1 precursor 0.0214 0.0089 0.0093
Echinococcus multilocularis mitogen activated protein kinase 14 0.0477 0.1025 0.1065
Trichomonas vaginalis CAMK family protein kinase 0.0806 0.2195 0.81
Brugia malayi p70 ribosomal S6 kinase beta 0.0828 0.2272 0.2377
Onchocerca volvulus 0.0191 0.0007 0.0012
Trichomonas vaginalis CAMK family protein kinase 0.0346 0.0561 0.1996
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0254 0.0231 0.0363
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0806 0.2195 0.2297
Trichomonas vaginalis CMGC family protein kinase 0.0293 0.0373 0.1293
Schistosoma mansoni atypical protein kinase C 0.0849 0.2347 0.245
Loa Loa (eye worm) TK/FER protein kinase 0.0283 0.0334 0.035
Echinococcus granulosus roundabout 2 0.0378 0.0672 0.0665
Echinococcus granulosus tyrosine protein kinase Fyn 0.0654 0.1654 0.1648
Entamoeba histolytica protein kinase, putative 0.0854 0.2366 0.7088
Brugia malayi Tyrosine-protein kinase abl-1 0.0379 0.0678 0.071
Entamoeba histolytica protein kinase, putative 0.0293 0.0373 0.1075
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0477 0.1025 0.3485
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0368 0.0636 0.1943
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.026 0.0255 0.0248
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0417 0.0812 0.2662
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0543 0.126 0.1254
Echinococcus granulosus tyrosine protein kinase Fps85D 0.1181 0.3529 0.3524
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0304 0.0411 0.0835
Trypanosoma cruzi SNF1-related protein kinases, putative 0.027 0.029 0.0637
Brugia malayi Protein kinase domain containing protein 0.0558 0.1312 0.1373
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0227 0.0138 0.013
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.0606 0.1483 0.1545
Entamoeba histolytica protein kinase domain containing protein 0.0368 0.0636 0.187
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0293 0.0373 0.039
Echinococcus granulosus calcium dependent protein kinase 0.0201 0.0044 0.0037
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0252 0.0224 0.0337
Loa Loa (eye worm) hypothetical protein 0.0254 0.0233 0.0244
Schistosoma mansoni serine/threonine protein kinase 0.0314 0.0447 0.046
Brugia malayi Kinase associated domain 1 family protein 0.0211 0.008 0.0084
Brugia malayi MAP kinase sur-1 0.0254 0.0231 0.0241
Echinococcus multilocularis tyrosine protein kinase shark 0.0915 0.2582 0.2697
Trichomonas vaginalis CAMK family protein kinase 0.027 0.029 0.0986
Entamoeba histolytica protein kinase domain containing protein 0.0293 0.0373 0.1075
Entamoeba histolytica serine/threonine protein kinase, putative 0.027 0.029 0.0827
Loa Loa (eye worm) AGC/PKA protein kinase 0.034 0.0539 0.0564
Plasmodium falciparum calcium-dependent protein kinase 2 0.0304 0.0411 0.1065
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.029 0.036 0.0353
Schistosoma mansoni serine/threonine protein kinase 0.0702 0.1824 0.1902
Trypanosoma brucei SNF1-related protein kinases, putative 0.027 0.029 0.0595
Echinococcus multilocularis dual specificity 0.0417 0.0812 0.0843
Brugia malayi cyclin-dependent kinase 9 0.0193 0.0016 0.0017
Schistosoma mansoni serine/threonine protein kinase 0.0606 0.1483 0.1545
Brugia malayi Temporarily assigned gene name protein 59 0.0382 0.0688 0.072
Trichomonas vaginalis AGC family protein kinase 0.0461 0.097 0.3524
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.06 0.1463 0.1456
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0283 0.0334 0.0959
Leishmania major casein kinase II, putative 0.0302 0.0403 0.1035
Echinococcus multilocularis phosphorylase kinase gamma subunit 0.0492 0.1077 0.112
Echinococcus granulosus protein kinase C gamma type 0.0583 0.1401 0.1394
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0246 0.0202 0.0251
Onchocerca volvulus 0.0283 0.0334 0.1017
Onchocerca volvulus 0.0293 0.0373 0.1135
Echinococcus multilocularis casein kinase I delta 0.0327 0.0493 0.0509
Schistosoma mansoni serine/threonine protein kinase 0.0357 0.06 0.0621
Echinococcus granulosus cyclin dependent kinase 1 0.0357 0.06 0.0593
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative 0.027 0.029 0.0595
Echinococcus multilocularis expressed conserved protein 0.0404 0.0766 0.0795
Loa Loa (eye worm) TK/INSR protein kinase 0.1316 0.4009 0.4195
Entamoeba histolytica casein kinase, putative 0.0327 0.0493 0.1438
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0469 0.0998 0.3383
Schistosoma mansoni ephrin receptor 0.0314 0.0445 0.0458
Loa Loa (eye worm) TK/ALK protein kinase 0.0825 0.2261 0.2366
Trichomonas vaginalis CAMK family protein kinase 0.027 0.029 0.0986
Trypanosoma cruzi serine/arginine-rich protein specific kinase SRPK, putative 0.0252 0.0224 0.0379
Giardia lamblia Kinase, NEK 0.0409 0.0783 0.2252
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.034 0.0539 0.1602
Schistosoma mansoni serine/threonine protein kinase 0.0461 0.0967 0.1005
Trichomonas vaginalis CMGC family protein kinase 0.0254 0.0231 0.0763
Echinococcus granulosus Immunoglobulin 0.0247 0.0208 0.02
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0352 0.0582 0.0609
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0461 0.0967 0.3231
Loa Loa (eye worm) hypothetical protein 0.0411 0.0791 0.0827
Giardia lamblia Kinase, CK1 Casein kinase 0.0327 0.0493 0.1085
Echinococcus multilocularis casein kinase I alpha 0.0327 0.0493 0.0509
Trichomonas vaginalis CAMK family protein kinase 0.0806 0.2195 0.81
Schistosoma mansoni tyrosine kinase 0.0217 0.0101 0.0098
Loa Loa (eye worm) hypothetical protein 0.034 0.0539 0.0564
Echinococcus multilocularis calcium activated potassium channel 0.0314 0.0447 0.046
Trichomonas vaginalis CAMK family protein kinase 0.027 0.029 0.0986
Loa Loa (eye worm) hypothetical protein 0.0331 0.0506 0.0529
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0711 0.1855 0.1942
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0711 0.1858 0.1939
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0304 0.0411 0.043
Echinococcus multilocularis casein kinase I delta 0.0327 0.0493 0.0509
Giardia lamblia Kinase, AGC PKA 0.034 0.0539 0.1271
Brugia malayi Protein kinase domain containing protein 0.1783 0.5667 0.593
Trichomonas vaginalis AGC family protein kinase 0.0488 0.1064 0.3875
Trypanosoma cruzi casein kinase II, putative 0.0302 0.0403 0.1074
Brugia malayi Protein kinase domain containing protein 0.0283 0.0334 0.035
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0654 0.1654 0.1725
Schistosoma mansoni protein kinase 0.0302 0.0403 0.0415
Trypanosoma cruzi polo-like protein kinase, putative 0.0806 0.2195 0.8026
Plasmodium falciparum glycogen synthase kinase 3 0.0293 0.0373 0.0915
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0254 0.0231 0.0405
Brugia malayi Casein kinase II, alpha chain 0.0302 0.0403 0.0422
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0461 0.0967 0.3261
Loa Loa (eye worm) CMGC/CDK/CDK7 protein kinase 0.0257 0.0243 0.0254
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.034 0.0539 0.0557
Echinococcus multilocularis activin receptor type 0.0227 0.0138 0.0137
Schistosoma mansoni hypothetical protein 0.0331 0.0506 0.0522
Echinococcus multilocularis protein kinase c epsilon type 0.0589 0.1423 0.1483
Loa Loa (eye worm) hypothetical protein 0.0279 0.0322 0.0337
Trichomonas vaginalis AGC family protein kinase 0.0477 0.1026 0.3734
Trichomonas vaginalis CAMK family protein kinase 0.0346 0.0561 0.1996
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0368 0.0636 0.1943
Echinococcus multilocularis casein kinase I gamma 0.0637 0.1594 0.1662
Brugia malayi hypothetical protein 0.0331 0.0506 0.0529
Echinococcus granulosus serine threonine protein kinase nrc 0.0469 0.0998 0.0992
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.027 0.029 0.0595
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0331 0.0506 0.0522
Entamoeba histolytica protein kinase domain containing protein 0.0417 0.0812 0.2401
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0215 0.0095 0.0088
Loa Loa (eye worm) hypothetical protein 0.0547 0.1274 0.1333
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0331 0.0506 0.0522
Giardia lamblia Kinase, CMGC CLK 0.0461 0.0967 0.2996
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0327 0.0493 0.0516
Loa Loa (eye worm) CAMK/PHK protein kinase 0.0492 0.1077 0.1127
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0331 0.0506 0.1473
Leishmania major protein kinase, putative 0.0461 0.0967 0.3231
Trichomonas vaginalis CMGC family protein kinase 0.0302 0.0403 0.1408
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0254 0.0231 0.0405
Echinococcus granulosus nervana 2 0.0366 0.0631 0.0625
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0357 0.06 0.0628
Brugia malayi Protein kinase domain containing protein 0.0492 0.1077 0.1127
Echinococcus granulosus c src tyrosine kinase 0.0393 0.0728 0.0721
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0368 0.0636 0.1978
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0254 0.0231 0.0363
Plasmodium falciparum NIMA related kinase 1 0.0409 0.0783 0.2513
Brugia malayi hypothetical protein 0.0279 0.0322 0.0337
Echinococcus multilocularis cyclin dependent kinase 1 0.0357 0.06 0.0621
Schistosoma mansoni serine/threonine protein kinase 0.0461 0.0967 0.1005
Trichomonas vaginalis CAMK family protein kinase 0.038 0.068 0.2441
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0282 0.0333 0.0341
Echinococcus granulosus calcium activated potassium channel 0.0314 0.0447 0.044
Brugia malayi Protein kinase domain containing protein 0.0461 0.0967 0.1012
Entamoeba histolytica protein kinase , putative 0.0949 0.2704 0.8107
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.034 0.0539 0.1602
Brugia malayi Protein kinase domain containing protein 0.0825 0.2262 0.2367
Entamoeba histolytica protein kinase, putative 0.0304 0.0411 0.119
Brugia malayi Protein kinase domain containing protein 0.0886 0.248 0.2595
Loa Loa (eye worm) TK/FER protein kinase 0.1181 0.3529 0.3693
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0357 0.06 0.0628
Trichomonas vaginalis CMGC family protein kinase 0.0357 0.06 0.2143
Echinococcus granulosus maternal embryonic leucine zipper kinase 0.0346 0.0561 0.0554
Brugia malayi protein kinase C3,putative 0.0473 0.1009 0.1056
Schistosoma mansoni serine/threonine kinase 0.0573 0.1368 0.1425
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0949 0.2704 0.8107
Brugia malayi cyclin-dependent kinase 7 homolog 0.0273 0.0299 0.0313
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0366 0.0631 0.0625
Echinococcus granulosus tyrosine protein kinase Lyn 0.0757 0.2021 0.2015
Echinococcus multilocularis NCK adaptor protein 0.0275 0.0307 0.0314
Loa Loa (eye worm) hypothetical protein 0.0331 0.0506 0.0529
Trichomonas vaginalis CK1 family protein kinase 0.0327 0.0493 0.1744
Loa Loa (eye worm) hypothetical protein 0.029 0.036 0.0377
Trichomonas vaginalis CAMK family protein kinase 0.0806 0.2195 0.81
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0461 0.0967 0.3261
Brugia malayi Immunoglobulin I-set domain containing protein 0.0191 0.0007 0.0008
Echinococcus multilocularis N chimaerin 0.0282 0.0333 0.0341
Echinococcus granulosus neuroglian 0.0303 0.0405 0.0398
Echinococcus granulosus tyrosine protein kinase shark 0.0915 0.2582 0.2577
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0293 0.0373 0.0915
Echinococcus multilocularis Glutaredoxin protein 5 0.0366 0.0631 0.0654
Entamoeba histolytica protein kinase, putative 0.0385 0.0697 0.2053
Echinococcus multilocularis raf serine:threonine protein kinase 0.0248 0.0211 0.0214
Echinococcus multilocularis cyclin dependent kinase 19 0.0357 0.06 0.0621
Loa Loa (eye worm) casein kinase 0.0534 0.1228 0.1284
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0556 0.1305 0.1299
Schistosoma mansoni tyrosine kinase 0.0711 0.1858 0.1939
Echinococcus multilocularis serine:threonine protein kinase N2 0.0846 0.2335 0.2438
Loa Loa (eye worm) SRC-1 0.0654 0.1654 0.1731
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0327 0.0493 0.1423
Trypanosoma cruzi casein kinase, putative 0.0327 0.0493 0.1423
Schistosoma mansoni serine/threonine protein kinase 0.034 0.0539 0.0557
Trypanosoma brucei serine/arginine-rich protein specific kinase SRPK, putative 0.0252 0.0224 0.0337
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0269 0.0286 0.03
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0304 0.0411 0.0835
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.027 0.029 0.0637
Schistosoma mansoni tyrosine kinase 0.0393 0.0728 0.0755
Echinococcus granulosus casein kinase i 0.0327 0.0493 0.0486
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0461 0.097 0.1008
Brugia malayi Fes/CIP4 homology domain containing protein 0.0336 0.0522 0.0546
Trypanosoma cruzi Protein kinase B 0.0496 0.1092 0.3748
Entamoeba histolytica protein kinase domain containing protein 0.0949 0.2704 0.8107
Brugia malayi SH2 domain containing protein 0.1181 0.3529 0.3693
Brugia malayi Immunoglobulin I-set domain containing protein 0.1339 0.409 0.428
Brugia malayi Variant SH3 domain containing protein 0.0269 0.0286 0.03
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0304 0.0411 0.0404
Trypanosoma brucei protein kinase, putative 0.0269 0.0287 0.0581
Loa Loa (eye worm) hypothetical protein 0.019 0.0003 0.0004
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0425 0.084 0.0872
Trichomonas vaginalis AGC family protein kinase 0.0949 0.2704 1
Schistosoma mansoni serine/threonine protein kinase 0.2877 0.9556 1
Entamoeba histolytica protein kinase, putative 0.026 0.0255 0.0719
Trichomonas vaginalis AGC family protein kinase 0.0263 0.0263 0.0884
Schistosoma mansoni serine/threonine protein kinase 0.0404 0.0766 0.0795
Schistosoma mansoni growth factor receptor-bound protein 0.0275 0.0307 0.0314
Schistosoma mansoni serine/threonine protein kinase 0.027 0.029 0.0296
Giardia lamblia Kinase, STE STE20 0.026 0.0255 0.0124
Loa Loa (eye worm) TK/FER protein kinase 0.0283 0.0334 0.035
Trichomonas vaginalis STE family protein kinase 0.0409 0.0783 0.2825
Toxoplasma gondii AGC kinase 0.0828 0.2272 0.8318
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.034 0.0539 0.1348
Trypanosoma brucei cdc2-related kinase 3 0.0357 0.06 0.1802
Echinococcus granulosus tyrosine protein kinase ABL1 0.0897 0.2518 0.2513
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0293 0.0373 0.0915
Echinococcus granulosus casein kinase ii subunit alpha 0.0302 0.0403 0.0396
Echinococcus multilocularis serine:threonine protein kinase 0.0223 0.0123 0.0122
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0366 0.0631 0.0654
Echinococcus granulosus homeodomain interacting protein kinase 3 0.0606 0.1483 0.1476
Echinococcus multilocularis tyrosine protein kinase Srms 0.0543 0.126 0.1312
Toxoplasma gondii AGC kinase 0.034 0.0539 0.1565
Echinococcus granulosus serine:threonine protein kinase 0.0223 0.0123 0.0116
Trichomonas vaginalis CMGC family protein kinase 0.0461 0.0967 0.3513
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0654 0.1654 0.1648
Plasmodium falciparum serine/threonine protein kinase 0.0252 0.0224 0.0337
Entamoeba histolytica PH domain containing protein kinase, putative 0.0367 0.0633 0.1861
Brugia malayi Fibronectin type III domain containing protein 0.0279 0.0322 0.0337
Brugia malayi Sex muscle abnormal protein 5 0.0269 0.0286 0.03
Onchocerca volvulus 0.0283 0.0334 0.1017
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.1291 0.3918 0.3914
Loa Loa (eye worm) hypothetical protein 0.0573 0.1368 0.1431
Echinococcus multilocularis cyclin dependent kinase 5 0.0357 0.06 0.0621
Schistosoma mansoni protein kinase 0.026 0.0255 0.0259
Trichomonas vaginalis CAMK family protein kinase 0.0806 0.2195 0.81
Loa Loa (eye worm) hypothetical protein 0.0241 0.0187 0.0196
Brugia malayi protein-tyrosine kinase 0.0543 0.126 0.1319
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0379 0.0676 0.2097
Plasmodium falciparum tyrosine kinase-like protein, putative 0.0246 0.0202 0.0251
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0237 0.0172 0.0173
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.034 0.0539 0.0532
Echinococcus multilocularis STE20 serine:threonine protein kinase 0.147 0.4555 0.4762
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.06 0.1463 0.1524
Schistosoma mansoni protein kinase 0.079 0.2138 0.2231
Brugia malayi RhoGAP domain containing protein 0.0282 0.0333 0.0348
Entamoeba histolytica protein kinase, putative 0.0196 0.0026 0.003
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0556 0.1305 0.1366
Brugia malayi Protein kinase domain containing protein 0.0252 0.0224 0.0235
Onchocerca volvulus 0.0925 0.2617 0.8036
Brugia malayi cell division control protein 2 homolog 0.0357 0.06 0.0628
Loa Loa (eye worm) hypothetical protein 0.0535 0.1231 0.1288
Echinococcus granulosus cGMP dependent protein kinase 0.0404 0.0766 0.0759
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.0664 0.1689 0.1761
Brugia malayi Protein kinase domain containing protein 0.0461 0.097 0.1015
Schistosoma mansoni tyrosine kinase 0.0915 0.2582 0.2697
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0459 0.0962 0.1006
Brugia malayi probable protein kinase 0.079 0.2138 0.2238
Loa Loa (eye worm) hypothetical protein 0.0223 0.0123 0.0129
Echinococcus granulosus tyrosine protein kinase Fyn 0.0654 0.1654 0.1648
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.0256 0.024 0.04
Trichomonas vaginalis STE family protein kinase 0.026 0.0255 0.0853
Echinococcus granulosus casein kinase I gamma 0.0637 0.1594 0.1588
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0293 0.0373 0.0366
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.0417 0.0812 0.263
Schistosoma mansoni tyrosine kinase 0.1181 0.3528 0.3687
Echinococcus multilocularis serine:threonine protein kinase N2 0.0384 0.0695 0.072
Giardia lamblia Kinase, CMGC GSK 0.0293 0.0373 0.0599
Schistosoma mansoni protein kinase 0.0459 0.0962 0.0999
Plasmodium vivax unspecified product 0.0302 0.0403 0.0804
Giardia lamblia Kinase, CMGC MAPK 0.0254 0.0231 0.0027
Schistosoma mansoni serine/threonine protein kinase 0.0215 0.0095 0.0092
Schistosoma mansoni tyrosine kinase 0.1057 0.3087 0.3225
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0357 0.06 0.1802
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0461 0.0967 0.3231
Loa Loa (eye worm) CAMK/PKD protein kinase 0.065 0.164 0.1717
Brugia malayi Protein kinase domain containing protein 0.06 0.1463 0.1531
Brugia malayi casein kinase 1, delta 0.0327 0.0493 0.0516
Echinococcus granulosus serine:threonine kinase SAD 1 0.027 0.029 0.0283
Plasmodium vivax casein kinase 1, putative 0.0327 0.0493 0.1164
Brugia malayi P38 map kinase family protein 2 0.0477 0.1025 0.1072
Echinococcus granulosus ephrin type A receptor 4 A 0.0314 0.0445 0.0438
Echinococcus granulosus casein kinase I alpha 0.0327 0.0493 0.0486
Echinococcus multilocularis rho associated protein kinase 0.0969 0.2773 0.2896
Loa Loa (eye worm) hypothetical protein 0.0425 0.0841 0.088
Schistosoma mansoni serine/threonine protein kinase 0.0461 0.097 0.1008
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.2796 0.9267 0.9697
Echinococcus multilocularis tyrosine protein kinase Blk 0.0543 0.126 0.1312
Echinococcus granulosus dual specificity 0.0417 0.0812 0.0806
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.034 0.0539 0.0532
Onchocerca volvulus 0.0283 0.0334 0.1017
Brugia malayi Protein kinase domain containing protein 0.1334 0.4072 0.4261
Echinococcus granulosus protein kinase c iota type 0.0831 0.2283 0.2277
Schistosoma mansoni serine/threonine protein kinase 0.0314 0.0447 0.046
Echinococcus granulosus cGMP dependent protein kinase 1 0.0404 0.0766 0.0759
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0469 0.0998 0.0992
Leishmania major protein kinase A catalytic subunit 0.034 0.0539 0.1565
Trypanosoma cruzi casein kinase, putative 0.0327 0.0493 0.1423
Schistosoma mansoni serine/threonine protein kinase 0.027 0.029 0.0296
Trichomonas vaginalis AGC family protein kinase 0.0854 0.2366 0.8739
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0654 0.1654 0.1725
Brugia malayi Protein kinase domain containing protein 0.2796 0.9267 0.9697
Entamoeba histolytica protein kinase 2, putative 0.0469 0.0998 0.2962
Schistosoma mansoni serine/threonine protein kinase 0.0314 0.0447 0.046
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0263 0.0263 0.0275
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0886 0.248 0.2595
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0526 0.12 0.1256
Echinococcus granulosus casein kinase I delta 0.0327 0.0493 0.0486
Plasmodium vivax serine/threonine protein kinase, putative 0.0252 0.0224 0.0088
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0304 0.0411 0.0404
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0269 0.0286 0.03
Schistosoma mansoni serine/threonine protein kinase 0.0435 0.0874 0.0908
Schistosoma mansoni protein kinase 0.1092 0.3211 0.3355
Brugia malayi Hr1 repeat family protein 0.0846 0.2335 0.2443
Brugia malayi C1-like domain containing protein 0.065 0.164 0.1717
Trypanosoma cruzi casein kinase, putative 0.0327 0.0493 0.1423
Echinococcus multilocularis serine:threonine protein kinase 38 0.0461 0.097 0.1008
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0711 0.1855 0.1935
Giardia lamblia Kinase, AGC PKA 0.0469 0.0998 0.3122
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0806 0.2195 0.2189
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0654 0.1654 0.1725
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0293 0.0373 0.0382
Brugia malayi Immunoglobulin I-set domain containing protein 0.0767 0.2056 0.2151
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0282 0.0333 0.0326
Trichomonas vaginalis CMGC family protein kinase 0.0417 0.0812 0.2936
Echinococcus multilocularis maternal embryonic leucine zipper kinase 0.0346 0.0561 0.058
Echinococcus multilocularis death associated protein kinase 1 0.2518 0.8282 0.8665
Schistosoma mansoni vam6/vps39 related 0.0331 0.0506 0.0522
Loa Loa (eye worm) TK/FER protein kinase 0.0283 0.0334 0.035
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0304 0.0411 0.0404
Brugia malayi phosphoinositide-dependent protein kinase I 0.0247 0.0207 0.0217
Echinococcus multilocularis cyclin dependent kinase 9 0.0209 0.0073 0.0068
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0469 0.0998 0.3354
Schistosoma mansoni serine/threonine-protein kinase 0.0496 0.1092 0.1136
Entamoeba histolytica serine/threonine protein kinase, putative 0.0806 0.2195 0.6572
Entamoeba histolytica protein kinase, putative 0.0247 0.0207 0.0575
Trypanosoma cruzi casein kinase, putative 0.0327 0.0493 0.1423
Trichomonas vaginalis AGC family protein kinase 0.0247 0.0207 0.0675
Trypanosoma cruzi polo-like protein kinase, putative 0.0806 0.2195 0.8026
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0949 0.2704 0.2824
Brugia malayi SRC-1 0.0654 0.1654 0.1731
Schistosoma mansoni tyrosine kinase 0.0654 0.1654 0.1725
Plasmodium falciparum calcium-dependent protein kinase 3 0.0304 0.0411 0.1065
Echinococcus multilocularis hypothetical protein 0.0211 0.008 0.0076
Schistosoma mansoni nephrin 0.0335 0.0519 0.0536
Loa Loa (eye worm) STE/STE20/SLK protein kinase 0.0577 0.1379 0.1443
Plasmodium falciparum casein kinase 2, alpha subunit 0.0302 0.0403 0.1035
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0461 0.0967 0.3261
Schistosoma mansoni kinase 0.0193 0.0016 0.0009
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0589 0.1423 0.149
Schistosoma mansoni kinase 0.0861 0.2389 0.2494
Entamoeba histolytica casein kinase, putative 0.0302 0.0403 0.1167
Trichomonas vaginalis AGC family protein kinase 0.0854 0.2366 0.8739
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0654 0.1654 0.1725
Echinococcus multilocularis dual specificity 0.0417 0.0812 0.0843
Plasmodium falciparum calcium-dependent protein kinase 5 0.0304 0.0411 0.1065
Schistosoma mansoni tyrosine kinase 0.1316 0.4009 0.419
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.1783 0.5667 0.593
Entamoeba histolytica PH domain containing protein kinase, putative 0.0367 0.0633 0.1861
Echinococcus multilocularis casein kinase i 0.0327 0.0493 0.0509
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0247 0.0207 0.0217
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.026 0.0255 0.0259
Trypanosoma cruzi cdc2-related kinase 1 0.0357 0.06 0.1838
Trichomonas vaginalis AGC family protein kinase 0.0949 0.2704 1
Schistosoma mansoni serine/threonine protein kinase 0.0404 0.0766 0.0795
Schistosoma mansoni vesicular amine transporter 0.0247 0.0208 0.021
Echinococcus granulosus dual specificity 0.0368 0.0636 0.0629
Trichomonas vaginalis AGC family protein kinase 0.034 0.0539 0.1915
Schistosoma mansoni nck2/grb4 0.0269 0.0286 0.0292
Trichomonas vaginalis CAMK family protein kinase 0.027 0.029 0.0986
Loa Loa (eye worm) hypothetical protein 0.0873 0.2431 0.2544
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.0417 0.0812 0.085
Schistosoma mansoni hypothetical protein 0.0211 0.008 0.0076
Trichomonas vaginalis CAMK family protein kinase 0.0558 0.1312 0.4802
Schistosoma mansoni serine/threonine protein kinase 0.0193 0.0016 0.0009
Schistosoma mansoni tyrosine kinase 0.0654 0.1654 0.1725
Entamoeba histolytica protein kinase, putative 0.0461 0.097 0.2876
Brugia malayi Protein kinase domain containing protein 0.0579 0.1389 0.1454
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.034 0.0539 0.0564
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0282 0.0333 0.0341
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.034 0.0539 0.1565
Schistosoma mansoni tyrosine kinase 0.1057 0.3087 0.3225
Entamoeba histolytica cell division protein kinase 2, putative 0.0357 0.06 0.1761
Entamoeba histolytica PH domain containing protein kinase, putative 0.0496 0.1092 0.3246
Trichomonas vaginalis AGC family protein kinase 0.0461 0.097 0.3524
Schistosoma mansoni protein kinase 0.1291 0.3918 0.4095
Brugia malayi protein kinase C II. 0.0589 0.1423 0.149
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0711 0.1858 0.1852
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0256 0.024 0.0443
Echinococcus granulosus protein kinase shaggy 0.0293 0.0373 0.0366
Trichomonas vaginalis CAMK family protein kinase 0.027 0.029 0.0986
Trypanosoma brucei aurora B kinase 0.0949 0.2704 1
Schistosoma mansoni tyrosine kinase 0.1079 0.3164 0.3306
Schistosoma mansoni protein kinase 0.0327 0.0493 0.0509
Leishmania major protein kinase, putative 0.0949 0.2704 1
Toxoplasma gondii CMGC kinase, CK2 family 0.0302 0.0403 0.1035
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0987 0.2839 0.297
Echinococcus granulosus epidermal growth factor receptor 0.1181 0.3528 0.3524
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0286 0.0347 0.0578
Schistosoma mansoni rap gtpase-activating protein 0.0331 0.0506 0.0522
Echinococcus granulosus tyrosine protein kinase 0.0834 0.2295 0.229
Echinococcus multilocularis casein kinase ii subunit alpha 0.0302 0.0403 0.0415
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0304 0.0411 0.0423
Echinococcus granulosus tyrosine protein kinase Srms 0.149 0.4627 0.4623
Echinococcus granulosus NCK adaptor protein 0.0269 0.0286 0.0279
Trichomonas vaginalis CMGC family protein kinase 0.0302 0.0403 0.1408
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0327 0.0493 0.0516
Giardia lamblia Kinase, CMGC CDK 0.0357 0.06 0.1516
Trichomonas vaginalis AGC family protein kinase 0.0854 0.2366 0.8739
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0304 0.0411 0.0423
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.026 0.0255 0.0248
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0227 0.0138 0.0044
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.1334 0.4072 0.4261
Echinococcus multilocularis serine:threonine protein kinase N2 0.0461 0.097 0.1008
Echinococcus multilocularis nervana 2 0.0366 0.0631 0.0654
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0269 0.0286 0.0292
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0224 0.0127 0.0133
Trichomonas vaginalis CAMK family protein kinase 0.027 0.029 0.0986
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0654 0.1654 0.1725
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0227 0.0138 0.0137
Brugia malayi Stress-activated protein kinase jnk-1 0.2877 0.9556 1
Brugia malayi Protein kinase domain containing protein 0.0247 0.0207 0.0217
Trichomonas vaginalis CK1 family protein kinase 0.0327 0.0493 0.1744
Echinococcus granulosus tyrosine protein kinase Src64B 0.0654 0.1654 0.1648
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0234 0.016 0.0167
Loa Loa (eye worm) hypothetical protein 0.0331 0.0506 0.0529
Echinococcus granulosus tyrosine kinase 0.0543 0.126 0.1254
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.2877 0.9556 1
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0469 0.0998 0.3183
Trypanosoma cruzi cdc2-related kinase 3 0.0357 0.06 0.1838
Loa Loa (eye worm) AGC/PKA protein kinase 0.034 0.0539 0.0564
Loa Loa (eye worm) protein kinase domain-containing protein 0.0637 0.1594 0.1668
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0304 0.0411 0.043
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0254 0.0231 0.0405
Trichomonas vaginalis CMGC family protein kinase 0.0302 0.0403 0.1408
Leishmania major protein kinase, putative 0.0304 0.0411 0.1065
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0409 0.0783 0.2321
Brugia malayi serine/threonine-protein kinase plk-2 0.0806 0.2195 0.2297
Schistosoma mansoni serine/threonine protein kinase 0.0252 0.0224 0.0227
Loa Loa (eye worm) TK/EPH protein kinase 0.0366 0.063 0.0659
Trichomonas vaginalis CMGC family protein kinase 0.0417 0.0812 0.2936
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0304 0.0411 0.1065
Brugia malayi Protein kinase domain containing protein 0.0834 0.2295 0.2402
Echinococcus granulosus mitogen activated protein kinase 0.0254 0.0231 0.0224
Brugia malayi Tyrosine-protein kinase abl-1 0.0628 0.1563 0.1636
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0254 0.0231 0.0405
Schistosoma mansoni serine/threonine protein kinase 0.0461 0.097 0.1008
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.06 0.1463 0.1531
Echinococcus granulosus serine:threonine protein kinase N2 0.0846 0.2335 0.2329
Giardia lamblia Kinase, CAMK CAMKL 0.0286 0.0347 0.0494
Echinococcus granulosus serine/threonine protein kinase 0.0496 0.1092 0.1086
Loa Loa (eye worm) hypothetical protein 0.0423 0.0833 0.0872
Trichomonas vaginalis CMGC family protein kinase 0.0417 0.0812 0.2936
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0461 0.097 0.0963
Brugia malayi Egg laying defective protein 4 0.0404 0.0766 0.0802
Echinococcus granulosus cyclin dependent kinase 7 0.0257 0.0243 0.0235
Echinococcus granulosus protein kinase c epsilon type 0.0589 0.1423 0.1417
Echinococcus granulosus NDR protein kinase 0.0461 0.097 0.0963
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0302 0.0403 0.0804
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0828 0.2272 0.2377
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0293 0.0373 0.0956
Echinococcus granulosus insulin growth factor 1 receptor beta 0.1348 0.4123 0.4118
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0461 0.097 0.1015
Giardia lamblia Kinase, CMGC DYRK 0.0417 0.0812 0.2373
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.1181 0.3528 0.3524
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0331 0.0506 0.1473
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.0256 0.024 0.0676
Echinococcus granulosus aurora kinase A 0.0949 0.2704 0.2698
Loa Loa (eye worm) hypothetical protein 0.0247 0.0208 0.0217
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0693 0.1793 0.1876
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0417 0.0812 0.263
Toxoplasma gondii AGC kinase 0.034 0.0539 0.1565
Loa Loa (eye worm) TK/FER protein kinase 0.0283 0.0334 0.035
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.027 0.029 0.0304
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0237 0.0172 0.0165
Entamoeba histolytica protein kinase, putative 0.0828 0.2272 0.6804
Schistosoma mansoni protein kinase 0.0227 0.0138 0.0137
Plasmodium falciparum calcium-dependent protein kinase 1 0.0304 0.0411 0.1065
Giardia lamblia Kinase, CMGC GSK 0.0293 0.0373 0.0599
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0435 0.0874 0.0908
Onchocerca volvulus 0.0331 0.0506 0.1545
Echinococcus granulosus cyclin dependent kinase 9 0.0209 0.0073 0.0065
Loa Loa (eye worm) hypothetical protein 0.0211 0.008 0.0084
Schistosoma mansoni serine/threonine protein kinase 0.0304 0.0411 0.0423
Loa Loa (eye worm) TK/FER protein kinase 0.0283 0.0334 0.035
Echinococcus granulosus nervana 2 0.0366 0.0631 0.0625
Echinococcus granulosus fibroblast growth factor receptor 4 0.0711 0.1858 0.1852
Brugia malayi Protein kinase domain containing protein 0.0283 0.0334 0.035
Onchocerca volvulus 0.0547 0.1274 0.3905
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0886 0.248 0.2475
Trichomonas vaginalis CAMK family protein kinase 0.027 0.029 0.0986
Echinococcus granulosus dual specificity protein kinase clk2 0.0461 0.0967 0.096
Loa Loa (eye worm) TK/EGFR protein kinase 0.1798 0.572 0.5986
Echinococcus granulosus cyclin dependent kinase 9 0.0193 0.0016 0.0009
Echinococcus multilocularis serine:threonine protein kinase 0.0223 0.0123 0.0122
Echinococcus granulosus tyrosine kinase 0.0283 0.0334 0.0327
Schistosoma mansoni protein kinase 0.0949 0.2704 0.2824
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0886 0.248 0.2595
Echinococcus multilocularis tyrosine kinase 0.0283 0.0334 0.0342
Echinococcus multilocularis growth factor receptor bound protein 2 0.0269 0.0286 0.0292
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0435 0.0874 0.0908
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.034 0.0539 0.1565
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0404 0.0766 0.245
Plasmodium vivax protein kinase Crk2 0.0357 0.06 0.1591
Loa Loa (eye worm) CAMK protein kinase 0.0191 0.0007 0.0008
Giardia lamblia Kinase, NEK 0.0409 0.0783 0.2252
Loa Loa (eye worm) TK protein kinase 0.0767 0.2056 0.2151
Brugia malayi SH2 domain containing protein 0.0283 0.0334 0.035
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.034 0.0539 0.0532
Trichomonas vaginalis STE family protein kinase 0.026 0.0255 0.0853
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0496 0.1092 0.3748
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0707 0.1841 0.192
Entamoeba histolytica protein kinase, putative 0.0368 0.0636 0.187
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0556 0.1305 0.1366
Trichomonas vaginalis CAMK family protein kinase 0.027 0.029 0.0986
Trichomonas vaginalis AGC family protein kinase 0.0949 0.2704 1
Echinococcus multilocularis rac serine:threonine kinase 0.0496 0.1092 0.1136
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0435 0.0874 0.0867
Echinococcus granulosus Protein kinase C brain isozyme 0.0707 0.1841 0.1835
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0304 0.0411 0.1065
Loa Loa (eye worm) hypothetical protein 0.0411 0.0791 0.0827
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0987 0.2836 0.2968
Echinococcus multilocularis dual specificity 0.0417 0.0812 0.0843
Loa Loa (eye worm) AGC/AKT protein kinase 0.0854 0.2366 0.2476
Echinococcus multilocularis epidermal growth factor receptor 0.1181 0.3528 0.3687
Plasmodium vivax calcium-dependent protein kinase, putative 0.0304 0.0411 0.0835
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0477 0.1025 0.3456
Brugia malayi Protein kinase domain 0.026 0.0255 0.0267
Trichomonas vaginalis CMGC family protein kinase 0.0357 0.06 0.2143
Schistosoma mansoni serine/threonine protein kinase 0.0711 0.1855 0.1935
Schistosoma mansoni serine/threonine protein kinase 0.0248 0.0211 0.0214
Echinococcus granulosus hypothetical protein 0.0357 0.06 0.0593
Toxoplasma gondii cell-cycle-associated protein kinase SRPK, putative 0.0252 0.0224 0.0337
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0227 0.0138 0.0044
Plasmodium falciparum casein kinase 1 0.0327 0.0493 0.1385
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0435 0.0874 0.0908
Echinococcus multilocularis myosin iiia 0.0256 0.024 0.0244
Echinococcus multilocularis calcium dependent protein kinase 0.0201 0.0044 0.0038
Loa Loa (eye worm) hypothetical protein 0.0357 0.06 0.0628
Echinococcus multilocularis mitogen activated protein kinase 11 0.0477 0.1025 0.1065
Loa Loa (eye worm) hypothetical protein 0.0283 0.0334 0.035
Plasmodium falciparum protein kinase 5 0.0357 0.06 0.1802
Entamoeba histolytica protein kinase domain containing protein 0.0606 0.1483 0.4423
Echinococcus granulosus dual specificity 0.0417 0.0812 0.0806
Entamoeba histolytica protein kinase, putative 0.0949 0.2704 0.8107
Schistosoma mansoni serine/threonine kinase 0.0461 0.097 0.1008
Onchocerca volvulus 0.0283 0.0334 0.1017
Echinococcus granulosus c-Jun N-terminal kinases 0.2877 0.9556 0.9556
Loa Loa (eye worm) hypothetical protein 0.0304 0.0411 0.043
Trichomonas vaginalis CK1 family protein kinase 0.0327 0.0493 0.1744
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0469 0.0998 0.1038
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0215 0.0095 0.0088
Echinococcus granulosus cyclin dependent kinase 0.0357 0.06 0.0593
Brugia malayi Variant SH3 domain containing protein 0.0282 0.0333 0.0348
Trichomonas vaginalis CMGC family protein kinase 0.0357 0.06 0.2143
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0461 0.0967 0.3231
Brugia malayi Doublecortin family protein 0.0452 0.0937 0.0981
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.0606 0.1483 0.1551
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0368 0.0636 0.1978
Schistosoma mansoni tyrosine kinase 0.0223 0.0121 0.0118
Echinococcus granulosus Glutaredoxin protein 5 0.0366 0.0631 0.0625
Brugia malayi casein kinase I 0.0327 0.0493 0.0516
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0461 0.097 0.1008
Loa Loa (eye worm) TK/FER protein kinase 0.0283 0.0334 0.035
Trichomonas vaginalis CMGC family protein kinase 0.0302 0.0403 0.1408
Leishmania major casein kinase, putative 0.0327 0.0493 0.1385
Echinococcus granulosus MAP kinase activated protein kinase 2 0.1173 0.35 0.3495
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0711 0.1858 0.1939
Schistosoma mansoni serine/threonine protein kinase 0.0886 0.248 0.259
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0654 0.1654 0.1648
Schistosoma mansoni cell adhesion molecule 0.0322 0.0474 0.0489
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.026 0.0255 0.0259
Schistosoma mansoni serine/threonine protein kinase 0.027 0.029 0.0296
Entamoeba histolytica hypothetical protein 0.1126 0.3331 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.0254 0.0231 0.0234
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0247 0.0208 0.021
Echinococcus multilocularis 0.0514 0.1158 0.1205
Echinococcus granulosus casein kinase I delta 0.0327 0.0493 0.0486
Loa Loa (eye worm) hypothetical protein 0.0264 0.0269 0.0282
Echinococcus granulosus dual specificity 0.0417 0.0812 0.0806
Echinococcus granulosus tyrosine protein kinase HCK 0.0385 0.0697 0.069
Echinococcus granulosus twitchin 0.0406 0.0772 0.0765
Schistosoma mansoni serine/threonine protein kinase 0.0949 0.2704 0.2824
Onchocerca volvulus 0.0283 0.0334 0.1017
Loa Loa (eye worm) TK protein kinase 0.1023 0.2965 0.3103
Loa Loa (eye worm) gastrulation defective protein 1 0.0254 0.0233 0.0244
Schistosoma mansoni tyrosine kinase 0.1316 0.4009 0.419
Trichomonas vaginalis CAMK family protein kinase 0.027 0.029 0.0986
Trichomonas vaginalis CMGC family protein kinase 0.0302 0.0403 0.1408
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0434 0.0873 0.0866
Echinococcus granulosus insulin receptor 0.1316 0.4009 0.4004
Loa Loa (eye worm) hypothetical protein 0.0247 0.0208 0.0217
Echinococcus granulosus raf serine:threonine protein kinase 0.0248 0.0211 0.0204
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0304 0.0411 0.0835
Schistosoma mansoni protein kinase C mu 0.065 0.164 0.171
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0254 0.0231 0.0363
Entamoeba histolytica protein kinase, putative 0.0417 0.0812 0.2401
Schistosoma mansoni protein kinase 0.0227 0.0138 0.0137
Schistosoma mansoni serine/threonine protein kinase 0.0702 0.1824 0.1902
Entamoeba histolytica protein kinase, putative 0.0368 0.0636 0.187
Onchocerca volvulus 0.0865 0.2406 0.7386
Loa Loa (eye worm) TK/KIN16 protein kinase 0.1339 0.409 0.428
Echinococcus multilocularis Immunoglobulin 0.0247 0.0208 0.021
Trypanosoma brucei protein kinase, putative 0.0293 0.0373 0.0915
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0293 0.0373 0.0382
Echinococcus granulosus expressed protein 0.0252 0.0224 0.0217
Onchocerca volvulus 0.0423 0.0833 0.2551
Brugia malayi Protein kinase domain containing protein 0.0854 0.2366 0.2476
Toxoplasma gondii histone kinase SNF1, putative 0.027 0.029 0.0595
Schistosoma mansoni protein kinase 0.026 0.0255 0.0259
Trichomonas vaginalis CMGC family protein kinase 0.0254 0.0231 0.0763
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0702 0.1824 0.1818
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0191 0.0007 0.0008
Entamoeba histolytica protein kinase, putative 0.0262 0.0259 0.0733
Echinococcus granulosus activin receptor type 0.0227 0.0138 0.013
Schistosoma mansoni serine/threonine protein kinase 0.0806 0.2195 0.2291
Schistosoma mansoni growth factor receptor-bound protein 0.0269 0.0286 0.0292
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0949 0.2704 0.8107
Trichomonas vaginalis CAMK family protein kinase 0.0304 0.0411 0.1436
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0477 0.1025 0.1072
Schistosoma mansoni serine/threonine protein kinase 0.0357 0.06 0.0621
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0304 0.0411 0.0423
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.026 0.0255 0.0259
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0477 0.1025 0.3456
Trichomonas vaginalis CAMK family protein kinase 0.038 0.068 0.2441
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.1092 0.3211 0.3206
Schistosoma mansoni tyrosine kinase 0.0757 0.2019 0.2107
Trichomonas vaginalis CAMK family protein kinase 0.0806 0.2195 0.81
Giardia lamblia Kinase, AGC AKT 0.0352 0.0582 0.1442
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative 0.027 0.029 0.0595
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0404 0.0766 0.0795
Trichomonas vaginalis CAMK family protein kinase 0.0806 0.2195 0.81
Echinococcus granulosus N chimaerin 0.0282 0.0333 0.0326
Echinococcus multilocularis dual specificity 0.0368 0.0636 0.0659
Onchocerca volvulus Serine\/threonine kinase homolog 0.0492 0.1077 0.33
Leishmania major protein kinase A catalytic subunit isoform 2 0.034 0.0539 0.1565
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.1291 0.3918 0.4095
Brugia malayi Protein kinase domain containing protein 0.0577 0.1379 0.1443
Schistosoma mansoni serine/threonine protein kinase 0.0327 0.0493 0.0509
Trichomonas vaginalis AGC family protein kinase 0.0247 0.0207 0.0675
Echinococcus multilocularis serine:threonine kinase SAD 1 0.027 0.029 0.0296
Brugia malayi Homeodomain interacting protein kinase protein 1 0.0606 0.1483 0.1551
Trypanosoma cruzi aurora B kinase, putative 0.0949 0.2704 1
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0247 0.0208 0.021
Trichomonas vaginalis CAMK family protein kinase 0.027 0.029 0.0986
Plasmodium falciparum cGMP-dependent protein kinase 0.0404 0.0766 0.245
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0215 0.0095 0.0092
Schistosoma mansoni tyrosine kinase 0.0393 0.0728 0.0755
Trichomonas vaginalis CMGC family protein kinase 0.0302 0.0403 0.1408
Brugia malayi serine/threonine-protein kinase PAK 7 0.0693 0.1793 0.1876
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.1348 0.4123 0.431
Loa Loa (eye worm) hypothetical protein 0.1783 0.5667 0.593
Echinococcus granulosus mitogen activated protein kinase 3 0.0254 0.0231 0.0224
Brugia malayi putative serine/threonine kinase SADA gamma 0.027 0.029 0.0304
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0886 0.248 0.2595
Brugia malayi hypothetical protein 0.0664 0.1689 0.1767
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0886 0.248 0.7615
Schistosoma mansoni serine/threonine protein kinase 0.0761 0.2034 0.2123
Onchocerca volvulus 0.0573 0.1368 0.4195
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0304 0.0411 0.1065
Schistosoma mansoni protein kinase 0.1291 0.3918 0.4095
Echinococcus multilocularis mitogen activated protein kinase 11 0.0477 0.1025 0.1065
Echinococcus multilocularis tyrosine protein kinase HCK 0.0385 0.0697 0.0722
Echinococcus granulosus STE20 serine:threonine protein kinase 0.147 0.4555 0.4551
Trypanosoma brucei rac serine-threonine kinase, putative 0.0854 0.2366 0.8685
Schistosoma mansoni serine/threonine protein kinase 0.06 0.1463 0.1524
Onchocerca volvulus 0.0411 0.0791 0.242
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.034 0.0539 0.0557
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.034 0.0539 0.1565
Echinococcus multilocularis c Jun NH2 terminal kinase 0.2877 0.9556 1
Trichomonas vaginalis STE family protein kinase 0.026 0.0255 0.0853
Trichomonas vaginalis STE family protein kinase 0.026 0.0255 0.0853
Echinococcus granulosus mitogen activated protein kinase 11 0.0477 0.1025 0.1018
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0293 0.0373 0.039
Trichomonas vaginalis CMGC family protein kinase 0.0302 0.0403 0.1408
Brugia malayi Protein kinase domain containing protein 0.1092 0.3211 0.336
Trichomonas vaginalis AGC family protein kinase 0.0854 0.2366 0.8739
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0435 0.0874 0.0868
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.1783 0.5667 0.593
Trypanosoma cruzi cdc2-related kinase 1 0.0357 0.06 0.1838
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0282 0.0333 0.0341
Brugia malayi Serine/threonine-protein kinase SULU 0.0664 0.1689 0.1767
Loa Loa (eye worm) CMGC/SRPK protein kinase 0.0252 0.0224 0.0235
Trichomonas vaginalis CMGC family protein kinase 0.0254 0.0231 0.0763
Echinococcus granulosus defective proboscis extension response 0.0247 0.0208 0.02
Echinococcus multilocularis cyclin dependent kinase 7 0.0257 0.0243 0.0246
Trichomonas vaginalis CAMK family protein kinase 0.0822 0.2251 0.831
Trypanosoma cruzi cdc2-related kinase 3 0.0357 0.06 0.1838
Schistosoma mansoni serine/threonine protein kinase 0.027 0.029 0.0296
Loa Loa (eye worm) AGC/PKG protein kinase 0.0404 0.0766 0.0802
Schistosoma mansoni tyrosine kinase 0.1181 0.3528 0.3687
Onchocerca volvulus Serine\/threonine kinase homolog 0.0806 0.2195 0.6738
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.1092 0.3211 0.3355
Schistosoma mansoni serine/threonine protein kinase 0.0589 0.1423 0.1483
Entamoeba histolytica protein kinase, putative 0.0949 0.2704 0.8107
Brugia malayi serine/threonine kinase 12 0.0949 0.2704 0.2829
Giardia lamblia Aurora kinase 0.0949 0.2704 1
Trypanosoma brucei cdc2-related kinase 1 0.0357 0.06 0.1802
Loa Loa (eye worm) hypothetical protein 0.0687 0.1771 0.1854
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0543 0.126 0.1312
Brugia malayi protein unc-22 0.0191 0.0007 0.0008
Brugia malayi Protein kinase domain containing protein 0.1316 0.4009 0.4195
Trichomonas vaginalis CMGC family protein kinase 0.0417 0.0812 0.2936
Echinococcus multilocularis cyclin dependent kinase 1 0.0357 0.06 0.0621
Schistosoma mansoni tyrosine kinase 0.1798 0.572 0.5983
Echinococcus granulosus cGMP dependent protein kinase 1 0.0404 0.0766 0.0759
Entamoeba histolytica protein kinase, putative 0.0308 0.0424 0.123
Brugia malayi serine/threonine-protein kinase 6 0.0949 0.2704 0.2829
Echinococcus granulosus epidermal growth factor receptor 0.1798 0.572 0.5717
Echinococcus granulosus serine:threonine protein kinase TAO1 0.0664 0.1689 0.1683
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0949 0.2704 1
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.1181 0.3529 0.3688
Brugia malayi Protein kinase domain containing protein 0.0283 0.0334 0.035
Brugia malayi Protein kinase domain containing protein 0.0357 0.06 0.0628
Trichomonas vaginalis CAMK family protein kinase 0.027 0.029 0.0986
Brugia malayi intracellular kinase 0.0293 0.0373 0.039
Trichomonas vaginalis STE family protein kinase 0.0256 0.024 0.08
Giardia lamblia Kinase, CMGC CDK 0.0357 0.06 0.1516
Entamoeba histolytica protein kinase, putative 0.0854 0.2366 0.7088
Giardia lamblia Kinase, CMGC CK2 0.0302 0.0403 0.0722
Loa Loa (eye worm) hypothetical protein 0.0423 0.0833 0.0872
Trichomonas vaginalis CMGC family protein kinase 0.0293 0.0373 0.1293
Echinococcus granulosus serine:threonine protein kinase N2 0.0384 0.0695 0.0688
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.026 0.0255 0.0248
Onchocerca volvulus 0.0969 0.2773 0.8514
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0282 0.0333 0.0348
Trypanosoma cruzi casein kinase, putative 0.0327 0.0493 0.1423
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0477 0.1025 0.3485
Echinococcus multilocularis ephrin type A receptor 4 A 0.0314 0.0445 0.0458
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0654 0.1654 0.1725
Loa Loa (eye worm) hypothetical protein 0.1057 0.3087 0.323
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.065 0.164 0.1717
Echinococcus multilocularis neuroglian 0.0303 0.0405 0.0416
Brugia malayi Immunoglobulin I-set domain containing protein 0.0279 0.0322 0.0337
Entamoeba histolytica PH domain containing protein kinase, putative 0.0496 0.1092 0.3246
Plasmodium falciparum serine/threonine protein kinase KIN 0.027 0.029 0.0595
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0987 0.2836 0.2968
Loa Loa (eye worm) AUR protein kinase 0.0949 0.2704 0.2829
Schistosoma mansoni vav2 0.0309 0.0427 0.044
Schistosoma mansoni serine/threonine protein kinase 0.034 0.0539 0.0557
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.034 0.0539 0.1602
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0806 0.2195 0.2291
Giardia lamblia Kinase, CAMK CAMKL 0.0286 0.0347 0.0494
Schistosoma mansoni serine/threonine-protein kinase 0.0496 0.1092 0.1136
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0304 0.0411 0.043
Schistosoma mansoni serine/threonine protein kinase 0.0846 0.2335 0.2438
Loa Loa (eye worm) TK/FER protein kinase 0.0283 0.0334 0.035
Giardia lamblia Kinase, NEK 0.0409 0.0783 0.2252
Echinococcus granulosus growth factor receptor bound protein 2 0.0275 0.0307 0.03
Schistosoma mansoni tyrosine kinase 0.0739 0.1955 0.2039
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0654 0.1654 0.1725
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0687 0.1771 0.1765
Onchocerca volvulus 0.0224 0.0126 0.0378
Echinococcus granulosus serine:threonine protein kinase 0.0223 0.0123 0.0116
Brugia malayi Protein kinase domain containing protein 0.1783 0.5667 0.593
Schistosoma mansoni serine/threonine protein kinase 0.1173 0.35 0.3657
Brugia malayi Temporarily assigned gene name protein 59 0.0331 0.0506 0.0529
Echinococcus multilocularis mitogen activated protein kinase 14 0.0477 0.1025 0.1065
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0393 0.0728 0.0755
Echinococcus multilocularis c src tyrosine kinase 0.0393 0.0728 0.0755
Plasmodium falciparum serine/threonine protein kinase, putative 0.0949 0.2704 1
Schistosoma mansoni serine/threonine protein kinase 0.0368 0.0636 0.0659
Entamoeba histolytica protein kinase domain containing protein 0.0227 0.0138 0.0366
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0247 0.0207 0.0209
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0304 0.0411 0.1065
Plasmodium vivax serine/threonine kinase-1, putative 0.0461 0.0967 0.3057
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0949 0.2704 0.8107
Onchocerca volvulus 0.0214 0.009 0.0266
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.0664 0.1689 0.1767
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.034 0.0539 0.1565
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.034 0.0539 0.0557
Echinococcus multilocularis protein kinase c iota type 0.0831 0.2283 0.2383
Loa Loa (eye worm) hypothetical protein 0.0279 0.0322 0.0337
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.1092 0.3211 0.336
Entamoeba histolytica protein kinase, putative 0.0223 0.0121 0.0314
Echinococcus granulosus cyclin dependent kinase 5 0.0357 0.06 0.0593
Loa Loa (eye worm) TK/FER protein kinase 0.0283 0.0334 0.035
Echinococcus multilocularis cyclin dependent kinase 9 0.0193 0.0016 0.0009
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0327 0.0493 0.0516
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0806 0.2195 0.8018
Schistosoma mansoni serine/threonine protein kinase 0.0357 0.06 0.0621
Echinococcus granulosus casein kinase I alpha 0.0327 0.0493 0.0486
Onchocerca volvulus 0.0283 0.0334 0.1017
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0654 0.1654 0.1725
Schistosoma mansoni serine/threonine protein kinase 0.1418 0.4371 0.457
Brugia malayi Protein kinase domain containing protein 0.0357 0.06 0.0628
Trypanosoma brucei casein kinase I, isoform 2 0.0327 0.0493 0.1385
Loa Loa (eye worm) hypothetical protein 0.0617 0.1521 0.1592
Onchocerca volvulus Tyrosine kinase homolog 0.1105 0.3256 1
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.0256 0.024 0.0676
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0256 0.024 0.0443
Leishmania major protein kinase A catalytic subunit isoform 1 0.034 0.0539 0.1565
Brugia malayi Protein kinase domain containing protein 0.0637 0.1594 0.1668
Loa Loa (eye worm) hypothetical protein 0.0352 0.0582 0.0609
Echinococcus multilocularis 0.0459 0.0962 0.0999
Echinococcus multilocularis cyclin dependent kinase 0.0357 0.06 0.0621
Brugia malayi Furin-like cysteine rich region family protein 0.1798 0.572 0.5986
Loa Loa (eye worm) hypothetical protein 0.0345 0.0557 0.0583
Echinococcus multilocularis aurora kinase A 0.0949 0.2704 0.2824
Trichomonas vaginalis AGC family protein kinase 0.0854 0.2366 0.8739
Schistosoma mansoni serine/threonine protein kinase 0.0492 0.1077 0.112
Trichomonas vaginalis CMGC family protein kinase 0.0254 0.0231 0.0763
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0556 0.1305 0.1359
Trichomonas vaginalis CAMK family protein kinase 0.027 0.029 0.0986
Plasmodium falciparum protein serine/threonine kinase-1 0.0461 0.0967 0.3231
Entamoeba histolytica protein kinase, putative 0.0215 0.0095 0.0237
Plasmodium vivax glycogen synthase kinase 3, putative 0.0293 0.0373 0.0682
Schistosoma mansoni protein kinase 0.0196 0.0026 0.002
Giardia lamblia Kinase, PLK 0.0806 0.2195 0.7949
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0358 0.0603 0.2153
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0461 0.0967 0.3261
Echinococcus multilocularis casein kinase I alpha 0.0327 0.0493 0.0509
Entamoeba histolytica cell division protein kinase 2, putative 0.0373 0.0656 0.193
Echinococcus multilocularis protein kinase shaggy 0.0293 0.0373 0.0382
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.1184 0.3537 0.3696
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0897 0.2518 0.2629
Trichomonas vaginalis CMGC family protein kinase 0.0417 0.0812 0.2936
Schistosoma mansoni serine/threonine protein kinase 0.0707 0.1841 0.192
Loa Loa (eye worm) TK protein kinase 0.0543 0.126 0.1319
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0357 0.06 0.0628
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0766 0.2053 0.2149
Entamoeba histolytica protein kinase, putative 0.0252 0.0224 0.0627
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0357 0.06 0.1802
Trichomonas vaginalis CAMK family protein kinase 0.027 0.029 0.0986
Entamoeba histolytica protein kinase, putative 0.0215 0.0095 0.0237
Echinococcus multilocularis expressed protein 0.0252 0.0224 0.0227
Brugia malayi map kinase activated protein kinase protein 2 0.1173 0.35 0.3662
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0331 0.0506 0.0499
Entamoeba histolytica protein kinase domain containing protein 0.0302 0.0403 0.1167
Echinococcus multilocularis 0.0357 0.06 0.0621
Entamoeba histolytica hypothetical protein 0.0368 0.0636 0.187
Schistosoma mansoni tyrosine kinase 0.1057 0.3087 0.3225
Echinococcus multilocularis Immunoglobulin 0.0247 0.0208 0.021
Echinococcus granulosus tyrosine protein kinase Src42A 0.0654 0.1654 0.1648
Loa Loa (eye worm) AUR protein kinase 0.0949 0.2704 0.2829
Schistosoma mansoni serine/threonine protein kinase 0.0637 0.1594 0.1662
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0461 0.097 0.0963
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0949 0.2704 0.2698
Brugia malayi Protein kinase domain containing protein 0.0461 0.097 0.1015
Loa Loa (eye worm) hypothetical protein 0.0279 0.0322 0.0337
Echinococcus granulosus tyrosine protein kinase Fyn 0.0654 0.1654 0.1648
Echinococcus multilocularis PAK box P21 Rho binding 0.0196 0.0026 0.002
Echinococcus granulosus tyrosine protein kinase Blk 0.0543 0.126 0.1254
Loa Loa (eye worm) hypothetical protein 0.0264 0.0269 0.0282
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0886 0.248 0.259
Schistosoma mansoni serine/threonine protein kinase 0.034 0.0539 0.0557
Loa Loa (eye worm) hypothetical protein 0.0411 0.0791 0.0827
Echinococcus granulosus phosphorylase kinase gamma subunit 0.0492 0.1077 0.107
Echinococcus multilocularis insulin receptor 0.1316 0.4009 0.419
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0254 0.0231 0.0241
Echinococcus multilocularis serine:threonine protein kinase 3 0.0766 0.2053 0.2143
Schistosoma mansoni hypothetical protein 0.0211 0.008 0.0076
Echinococcus multilocularis roundabout 2 0.0378 0.0672 0.0695
Schistosoma mansoni ste20-related kinase 0.0613 0.1509 0.1573
Brugia malayi Cam kinase protein 1 0.0304 0.0411 0.043
Entamoeba histolytica protein kinase, putative 0.0223 0.0121 0.0314
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0357 0.06 0.0593
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.1173 0.35 0.3657
Echinococcus multilocularis casein kinase I alpha 0.0327 0.0493 0.0509
Schistosoma mansoni protein kinase 0.1291 0.3918 0.4095
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.034 0.0539 0.1602
Brugia malayi Protein kinase domain containing protein 0.0189 0.0001 0.0001
Brugia malayi Protein kinase domain containing protein 0.0283 0.0334 0.035
Trichomonas vaginalis AGC family protein kinase 0.0949 0.2704 1
Loa Loa (eye worm) CMGC/CDK/CDK9 protein kinase 0.0193 0.0016 0.0017
Schistosoma mansoni serine/threonine protein kinase 0.0707 0.1841 0.192
Trichomonas vaginalis CAMK family protein kinase 0.0223 0.0123 0.0362
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0302 0.0403 0.0422
Echinococcus granulosus rho-associated protein kinase 1 0.0969 0.2773 0.2767
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0558 0.1312 0.1373
Schistosoma mansoni serine/threonine protein kinase 0.0664 0.1689 0.1761
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0215 0.0095 0.0092
Entamoeba histolytica p21-activated kinase 0.0287 0.0349 0.1003
Mycobacterium ulcerans hypothetical protein 0.0301 0.0399 0.5
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0711 0.1855 0.1849
Schistosoma mansoni protein kinase 0.0227 0.0138 0.0137
Echinococcus multilocularis tyrosine protein kinase 0.0834 0.2295 0.2396
Toxoplasma gondii casein kinase I 0.0327 0.0493 0.1385
Entamoeba histolytica protein kinase, putative 0.0252 0.0224 0.0627
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0368 0.0636 0.0666
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.0417 0.0812 0.085
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0247 0.0208 0.021
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0491 0.1074 0.1123
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0702 0.1824 0.1902
Echinococcus granulosus cyclin dependent kinase 19 0.0357 0.06 0.0593
Loa Loa (eye worm) hypothetical protein 0.0345 0.0557 0.0583
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0409 0.0783 0.2513
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.1173 0.35 0.3662
Loa Loa (eye worm) AUR protein kinase 0.0949 0.2704 0.2829
Loa Loa (eye worm) hypothetical protein 0.0248 0.0211 0.0221
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0434 0.0873 0.0906
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0331 0.0506 0.1435
Schistosoma mansoni serine/threonine protein kinase 0.0969 0.2773 0.2896
Schistosoma mansoni serine/threonine protein kinase 0.0328 0.0495 0.0511
Toxoplasma gondii aurora kinase 0.0949 0.2704 1
Echinococcus multilocularis mitogen activated protein kinase 0.0254 0.0231 0.0234
Trichomonas vaginalis CAMK family protein kinase 0.027 0.029 0.0986
Entamoeba histolytica casein kinase 1, putative 0.0327 0.0493 0.1438
Echinococcus granulosus tyrosine protein kinase Src42A 0.0425 0.084 0.0833
Echinococcus granulosus casein kinase I alpha 0.0327 0.0493 0.0486
Giardia lamblia Kinase, STE STE20 0.0256 0.024 0.0066
Schistosoma mansoni serine/threonine protein kinase 0.0257 0.0243 0.0246
Brugia malayi STE20-like kinase MST 0.0766 0.2053 0.2149
Plasmodium falciparum calcium-dependent protein kinase 4 0.0304 0.0411 0.1065
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0254 0.0231 0.0363
Brugia malayi Protein kinase domain containing protein 0.0368 0.0636 0.0666
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0262 0.0259 0.0733
Trichomonas vaginalis CAMK family protein kinase 0.027 0.029 0.0986
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.0417 0.0812 0.263
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.034 0.0539 0.0557
Brugia malayi Protein kinase domain containing protein 0.0549 0.1283 0.1342
Loa Loa (eye worm) TK protein kinase 0.0834 0.2295 0.2402
Brugia malayi Protein kinase domain containing protein 0.0283 0.0334 0.035
Trichomonas vaginalis AGC family protein kinase 0.0854 0.2366 0.8739
Trypanosoma brucei polo-like protein kinase 0.0806 0.2195 0.8018
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0435 0.0874 0.0868
Trichomonas vaginalis CAMK family protein kinase 0.027 0.029 0.0986
Echinococcus multilocularis nervana 2 0.0366 0.0631 0.0654
Schistosoma mansoni serine/threonine protein kinase 0.0556 0.1305 0.1359
Trichomonas vaginalis CAMK family protein kinase 0.027 0.029 0.0986
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0247 0.0207 0.02
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0357 0.06 0.0628
Loa Loa (eye worm) TK protein kinase 0.0385 0.0697 0.0729
Schistosoma mansoni adapter molecule crk 0.0269 0.0286 0.0292

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 3300 nM Displacement of [3H]haTRAP from human PAR1 receptor in platelet membrane ChEMBL. 17574850
IC50 (binding) = 3300 nM Displacement of [3H]haTRAP from human PAR1 receptor in platelet membrane ChEMBL. 17574850

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.