Detailed information for compound 457859

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 392.923 | Formula: C18H17ClN2O2S2
  • H donors: 0 H acceptors: 1 LogP: 5.28 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: ClCSc1nc2sc3c(c2c(=O)n1c1ccc(cc1)OC)CCCC3
  • InChi: 1S/C18H17ClN2O2S2/c1-23-12-8-6-11(7-9-12)21-17(22)15-13-4-2-3-5-14(13)25-16(15)20-18(21)24-10-19/h6-9H,2-5,10H2,1H3
  • InChiKey: SRVMFFQZXFNEOD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0016 0.0044 0.0081
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0058 0.0521 0.0968
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0528 0.0978
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0039 0.0297 0.6763
Echinococcus granulosus GPCR family 2 0.0016 0.0043 0.008
Schistosoma mansoni hypothetical protein 0.0352 0.3827 0.767
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0435 0.0796
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0435 0.0806
Trypanosoma cruzi glutaminyl cyclase, putative 0.002 0.0088 0.0596
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0052 0.0453 0.0832
Mycobacterium leprae Probable lipase LipE 0.0035 0.0255 0.7802
Brugia malayi Nuclear hormone receptor E75 0.0052 0.045 0.0751
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0431 0.0788
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.015 0.1642
Trichomonas vaginalis adenylate cyclase, putative 0.0039 0.0297 0.0429
Mycobacterium tuberculosis Probable lipoprotein aminopeptidase LpqL 0.0027 0.0171 0.035
Loa Loa (eye worm) hypothetical protein 0.011 0.1108 0.2026
Mycobacterium ulcerans lipase LipD 0.0035 0.0255 0.064
Brugia malayi ecdysteroid receptor 0.011 0.1108 0.1963
Toxoplasma gondii hypothetical protein 0.002 0.0088 0.037
Loa Loa (eye worm) hypothetical protein 0.011 0.1108 0.2026
Mycobacterium leprae Possible regulatory protein 0.0039 0.0297 1
Echinococcus granulosus Ankyrin 0.0016 0.0044 0.0082
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0104 0.0125
Loa Loa (eye worm) hypothetical protein 0.005 0.0431 0.0788
Brugia malayi PAS domain containing protein 0.0148 0.1533 0.2748
Brugia malayi nuclear receptor RXR 0.0058 0.0521 0.0881
Echinococcus granulosus nuclear receptor 2DBD gamma 0.011 0.1108 0.2053
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0255 0.7802
Brugia malayi Cytochrome P450 family protein 0.0048 0.0407 0.0671
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0043 0.008
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0022 0.0106 0.0131
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0435 0.0795
Mycobacterium tuberculosis Conserved protein 0.002 0.0088 0.0069
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0043 0.0043
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.014 0.1437 0.1437
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0052 0.045 0.0824
Loa Loa (eye worm) hypothetical protein 0.0052 0.045 0.0824
Trichomonas vaginalis bromodomain-containing protein, putative 0.0047 0.0396 0.0614
Loa Loa (eye worm) hypothetical protein 0.0034 0.0251 0.046
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0.0044 0.0003
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0255 0.064
Loa Loa (eye worm) hypothetical protein 0.0052 0.0453 0.0829
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.011 0.1108 0.2158
Loa Loa (eye worm) hypothetical protein 0.0252 0.27 0.4939
Brugia malayi Nuclear hormone receptor family member nhr-3 0.011 0.1108 0.1963
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0088 0.0038
Loa Loa (eye worm) hypothetical protein 0.0052 0.045 0.0824
Brugia malayi Nuclear hormone receptor family member nhr-41 0.011 0.1108 0.1963
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.015 0.1509
Brugia malayi Nuclear hormone receptor family member nhr-40 0.011 0.1108 0.1963
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0088 0.0038
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0039 0.0297 0.0429
Leishmania major cytochrome p450-like protein 0.0022 0.0106 0.0753
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0022 0.0106 0.0131
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0431 0.0716
Leishmania major DNA polymerase kappa, putative 0.0021 0.0104 0.0719
Echinococcus multilocularis endoplasmic reticulum metallopeptidase 1 0.002 0.0088 0.0088
Schistosoma mansoni cytochrome P450 0.0022 0.0106 0.0128
Loa Loa (eye worm) serotonin transporter b 0.0067 0.0619 0.1132
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0435 0.0723
Loa Loa (eye worm) steroid hormone receptor 0.011 0.1108 0.2026
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0259 0.278 0.278
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0195 0.2061 0.3722
Brugia malayi Ets-domain containing protein 0.008 0.0768 0.1338
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0435 0.0435
Loa Loa (eye worm) hypothetical protein 0.011 0.1108 0.2026
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.011 0.1108 0.2026
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0144 0.149 0.149
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0569 0.1067
Loa Loa (eye worm) hypothetical protein 0.0052 0.045 0.0824
Brugia malayi laminin-like protein K08C7.3 precursor 0.0052 0.0453 0.0757
Loa Loa (eye worm) hypothetical protein 0.0058 0.0521 0.0952
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0255 0.0431
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0043 0.008
Loa Loa (eye worm) hypothetical protein 0.0052 0.045 0.0824
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0104 0.0068
Echinococcus granulosus Nuclear hormone receptor HR96 0.0052 0.045 0.0835
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0569 0.1067
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0022 0.0106 0.0131
Echinococcus multilocularis ecdysone induced protein 78C 0.011 0.1108 0.1108
Trypanosoma cruzi cytochrome P450, putative 0.0048 0.0407 1
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0195 0.2061 0.3722
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0068 0.0068
Mycobacterium tuberculosis Conserved protein 0.0035 0.0255 0.064
Schistosoma mansoni hypothetical protein 0.0144 0.149 0.2934
Loa Loa (eye worm) hypothetical protein 0.0058 0.0521 0.0952
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0222 0.0407
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0022 0.0106 0.0131
Echinococcus granulosus histone acetyltransferase KAT2B 0.0047 0.0396 0.0734
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0052 0.0453 0.0757
Loa Loa (eye worm) hypothetical protein 0.0035 0.0255 0.0467
Echinococcus granulosus neurogenic locus notch protein 0.0052 0.0453 0.0841
Brugia malayi laminin alpha chain 0.0052 0.0453 0.0757
Echinococcus granulosus endoplasmic reticulum metallopeptidase 1 0.002 0.0088 0.0164
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.011 0.1108 0.1108
Brugia malayi Nuclear hormone receptor family member nhr-31 0.011 0.1108 0.1963
Loa Loa (eye worm) norepinephrine transporter 0.0067 0.0619 0.1132
Echinococcus multilocularis pikachurin 0.0052 0.0453 0.0453
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0022 0.0106 0.203
Schistosoma mansoni glutaminyl-peptide cyclotransferase-related 0.002 0.0088 0.0092
Schistosoma mansoni nuclear receptor nhr-48 0.0052 0.045 0.0826
Schistosoma mansoni hypothetical protein 0.0352 0.3827 0.767
Brugia malayi Nuclear hormone receptor family member nhr-25 0.011 0.1108 0.1963
Brugia malayi Nuclear hormone receptor-like 1 0.011 0.1108 0.1963
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0104 0.0125
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.011 0.1108 0.2026
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0052 0.045 0.0758
Schistosoma mansoni glutaminyl cyclase (M28 family) 0.002 0.0088 0.0092
Loa Loa (eye worm) beta-lactamase 0.0035 0.0255 0.0467
Loa Loa (eye worm) solute carrier family 6 member 4 0.0067 0.0619 0.1132
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0022 0.0106 0.0131
Loa Loa (eye worm) hypothetical protein 0.0016 0.0043 0.0079
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0063 0.0575 0.1732
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.015 0.2427
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0047 0.0396 0.6014
Trichomonas vaginalis esterase, putative 0.0035 0.0255 0.035
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0022 0.0106 0.0131
Mycobacterium tuberculosis Conserved protein 0.0035 0.0255 0.064
Echinococcus multilocularis jun protein 0.0259 0.278 0.278
Loa Loa (eye worm) hypothetical protein 0.002 0.0088 0.0161
Onchocerca volvulus 0.0063 0.0569 0.098
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0528 0.157
Brugia malayi Nuclear hormone receptor family member nhr-1 0.011 0.1108 0.1963
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0104 0.1984
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0255 0.064
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0022 0.0106 0.0131
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0022 0.0106 0.0131
Brugia malayi Fli-1 protein 0.0244 0.2612 0.4736
Mycobacterium ulcerans beta-lactamase 0.0035 0.0255 0.064
Schistosoma mansoni hypothetical protein 0.014 0.1437 0.2826
Loa Loa (eye worm) acetyltransferase 0.0161 0.1675 0.3064
Brugia malayi photoreceptor-specific nuclear receptor 0.011 0.1108 0.1963
Brugia malayi nuclear hormone receptor 0.011 0.1108 0.1963
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0104 0.0125
Echinococcus multilocularis lamin dm0 0.0082 0.0789 0.0789
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.011 0.1108 0.1983
Schistosoma mansoni Fxna peptidase (M28 family) 0.002 0.0088 0.0092
Schistosoma mansoni nuclear receptor 0.0052 0.045 0.0826
Loa Loa (eye worm) nuclear receptor NHR-67 0.0052 0.045 0.0824
Schistosoma mansoni ap endonuclease 0.0018 0.0068 0.0051
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.004 0.031 0.031
Loa Loa (eye worm) hypothetical protein 0.002 0.0088 0.0161
Schistosoma mansoni cpg binding protein 0.0034 0.0243 0.0405
Brugia malayi Pre-SET motif family protein 0.0433 0.4739 0.8659
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0104 0.1984
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0022 0.0106 0.0131
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0255 0.064
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0195 0.2061 0.3722
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0088 0.0038
Trypanosoma brucei cytochrome P450, putative 0.0048 0.0407 1
Brugia malayi tailless protein 0.0052 0.045 0.0751
Mycobacterium ulcerans short chain dehydrogenase 0.0278 0.2995 1
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0039 0.0297 0.0429
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0068 0.0126
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0022 0.0106 0.0131
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0528 0.0983
Echinococcus granulosus death domain containing protein 0.0016 0.0043 0.008
Schistosoma mansoni tyrosinase precursor 0.0195 0.2061 0.4091
Loa Loa (eye worm) hypothetical protein 0.0038 0.0293 0.0536
Echinococcus granulosus histone acetyltransferase KAT2B 0.0156 0.1624 0.3011
Onchocerca volvulus 0.0195 0.2061 0.3759
Brugia malayi hypothetical protein 0.0058 0.0521 0.0881
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0022 0.0106 0.1127
Loa Loa (eye worm) hypothetical protein 0.0052 0.045 0.0824
Echinococcus multilocularis glutaminyl peptide cyclotransferase 0.002 0.0088 0.0088
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0058 0.0521 0.0952
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.015 0.2901
Mycobacterium ulcerans hypothetical protein 0.0035 0.0255 0.064
Loa Loa (eye worm) cytochrome P450 0.0022 0.0106 0.0194
Loa Loa (eye worm) hypothetical protein 0.0058 0.0521 0.0952
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0052 0.045 0.045
Brugia malayi nuclear hormone receptor 0.0052 0.045 0.0751
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0104 0.0114
Leishmania major protein kinase, putative 0.0039 0.0297 0.4521
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0104 0.0104
Schistosoma mansoni coup transcription factor 0.011 0.1108 0.2158
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0161 0.1675 0.3308
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0022 0.0106 0.0131
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0047 0.0396 0.6014
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0104 0.1075
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0255 0.0255
Schistosoma mansoni jun-related protein 0.021 0.2234 0.4441
Schistosoma mansoni ap endonuclease 0.0018 0.0068 0.0051
Echinococcus granulosus pikachurin 0.0052 0.0453 0.0841
Brugia malayi cytoplasmic intermediate filament protein 0.0044 0.0359 0.0583
Brugia malayi intermediate filament protein 0.0082 0.0789 0.1376
Onchocerca volvulus 0.0039 0.0297 0.0474
Onchocerca volvulus Protein ultraspiracle homolog 0.011 0.1108 0.1983
Brugia malayi Nuclear hormone receptor-like 1 0.0058 0.0521 0.0881
Loa Loa (eye worm) hypothetical protein 0.0058 0.0521 0.0952
Leishmania major glutaminyl cyclase, putative 0.002 0.0088 0.0398
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.0569 0.0569
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.011 0.1108 0.2026
Echinococcus granulosus GA binding protein alpha chain 0.008 0.0768 0.1425
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0047 0.0396 0.6544
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0255 0.064
Leishmania major hypothetical protein, conserved 0.0025 0.015 0.1623
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0569 0.1067
Schistosoma mansoni retinoic acid receptor RXR 0.011 0.1108 0.2158
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0259 0.278 0.5154
Onchocerca volvulus 0.0082 0.0789 0.1389
Echinococcus granulosus glutaminyl peptide cyclotransferase 0.002 0.0088 0.0164
Echinococcus multilocularis GA binding protein alpha chain 0.008 0.0768 0.0768
Echinococcus granulosus aryl hydrocarbon receptor 0.0039 0.0297 0.0551
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0022 0.0106 0.0131
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0255 0.035
Schistosoma mansoni cell polarity protein 0.0052 0.0453 0.0832
Plasmodium vivax SET domain protein, putative 0.0063 0.0569 1
Echinococcus multilocularis geminin 0.0352 0.3827 0.3827
Loa Loa (eye worm) hypothetical protein 0.0307 0.3323 0.6078
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0039 0.0297 0.0429
Trichomonas vaginalis guanylate cyclase, putative 0.0039 0.0297 0.0429
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0104 0.0194
Schistosoma mansoni lamin 0.0082 0.0789 0.1513
Brugia malayi cytochrome P450 0.0022 0.0106 0.0117
Schistosoma mansoni hypothetical protein 0.0454 0.4976 1
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0022 0.0106 0.0131
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0016 0.0043 0.0079
Mycobacterium ulcerans hypothetical protein 0.002 0.0088 0.0069
Schistosoma mansoni survival motor neuron protein 0.01 0.0991 0.1923
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0063 0.0569 0.1067
Onchocerca volvulus 0.0195 0.2061 0.3759
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.014 0.1437 0.2664
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0044 0.0359 0.0657
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0069 0.0637 0.1166
Brugia malayi Pre-SET motif family protein 0.0063 0.0569 0.0971
Schistosoma mansoni mixed-lineage leukemia protein mll 0.007 0.065 0.1231
Schistosoma mansoni nuclear hormone receptor 0.0052 0.045 0.0826
Loa Loa (eye worm) hypothetical protein 0.0035 0.0255 0.0467
Loa Loa (eye worm) hypothetical protein 0.011 0.1108 0.2026
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0022 0.0106 0.0131
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0052 0.045 0.0758
Onchocerca volvulus 0.011 0.1108 0.1983
Echinococcus multilocularis transfer RNA-Lys 0.011 0.1099 0.1099
Loa Loa (eye worm) hypothetical protein 0.0052 0.045 0.0824
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0039 0.0297 0.0544
Brugia malayi Nuclear hormone receptor family member nhr-19 0.011 0.1108 0.1963
Onchocerca volvulus 0.0203 0.2154 0.393
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0022 0.0106 0.1127
Schistosoma mansoni Tr4/Tr2 (homologue) 0.011 0.1108 0.2158
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0039 0.0297 0.5
Echinococcus multilocularis endoplasmic reticulum metallopeptidase 1 0.002 0.0088 0.0088
Mycobacterium tuberculosis Probable oxidoreductase 0.0278 0.2995 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0052 0.045 0.045
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0022 0.0106 0.0131
Brugia malayi hypoxia-induced factor 1 0.0459 0.5032 0.92
Schistosoma mansoni sodium/chloride dependent transporter 0.0067 0.0619 0.1168
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0022 0.0106 0.0131
Loa Loa (eye worm) hypothetical protein 0.0016 0.0043 0.0078
Schistosoma mansoni slit 0.0052 0.0453 0.0832
Loa Loa (eye worm) hypothetical protein 0.0021 0.0104 0.0191
Trypanosoma cruzi cytochrome P450, putative 0.0048 0.0407 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.011 0.1108 0.2158
Echinococcus granulosus ecdysone induced protein 78C 0.011 0.1108 0.2053
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0255 0.0467
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.011 0.1108 0.2053
Loa Loa (eye worm) hypothetical protein 0.0497 0.5467 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0067 0.0613 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.011 0.1108 0.2158
Echinococcus granulosus dna polymerase eta 0.0021 0.0104 0.0194
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.011 0.1108 0.2026
Brugia malayi Nuclear hormone receptor family member nhr-49 0.011 0.1108 0.1963
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0052 0.045 0.0835
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.011 0.1108 0.2026
Schistosoma mansoni zinc finger protein 0.0052 0.045 0.0826
Echinococcus granulosus geminin 0.0352 0.3827 0.7094
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0104 0.1984
Loa Loa (eye worm) cytochrome P450 family protein 0.0048 0.0407 0.0745
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0528 0.8427
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0297 0.0429
Echinococcus granulosus dnaJ subfamily B 0.0454 0.4976 0.9225
Brugia malayi CXXC zinc finger family protein 0.0032 0.0222 0.0331
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0022 0.0106 0.0131
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0104 0.1075
Brugia malayi hypothetical protein 0.0203 0.2154 0.3892
Onchocerca volvulus Fxna peptidase homolog 0.002 0.0088 0.0084
Echinococcus multilocularis thyroid hormone receptor alpha 0.025 0.2681 0.2681
Entamoeba histolytica hypothetical protein 0.0144 0.149 1
Onchocerca volvulus Fxna peptidase homolog 0.002 0.0088 0.0084
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0082 0.0789 0.1444
Schistosoma mansoni ets-related 0.0244 0.2612 0.5207
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0022 0.0106 0.0131
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.011 0.1108 0.2053
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0068 0.0046
Echinococcus granulosus cytochrome P450 2K1 0.0022 0.0106 0.0197
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0039 0.0297 0.0429
Onchocerca volvulus 0.0035 0.0255 0.0395
Echinococcus granulosus dna polymerase kappa 0.0021 0.0104 0.0194
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.011 0.1108 0.2053
Schistosoma mansoni hypothetical protein 0.0034 0.0251 0.0423
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0104 0.0104
Loa Loa (eye worm) ShTK domain-containing protein 0.0195 0.2061 0.3771
Brugia malayi hypothetical protein 0.0497 0.5467 1
Echinococcus granulosus thyroid hormone receptor alpha 0.0052 0.045 0.0835
Loa Loa (eye worm) hypothetical protein 0.0052 0.045 0.0824
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0063 0.0575 0.1079
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0435 0.0795
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0104 0.1984
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0104 0.1984
Loa Loa (eye worm) hypoxia-induced factor 1 0.0459 0.5032 0.9206
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.008 0.0768 0.1406
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0022 0.0106 0.0131
Schistosoma mansoni hypothetical protein 0.0022 0.0106 0.0128
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0022 0.0106 0.0131
Entamoeba histolytica hypothetical protein 0.0144 0.149 1
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0022 0.0106 0.0131
Onchocerca volvulus 0.0035 0.0255 0.0395
Toxoplasma gondii cytochrome p450 superfamily protein 0.0022 0.0106 0.07
Leishmania major protein kinase, putative 0.0039 0.0297 0.4521
Brugia malayi nuclear hormone receptor family member odr-7 0.0052 0.045 0.0751
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.011 0.1108 0.2026
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0052 0.045 0.0826
Brugia malayi Cytochrome P450 family protein 0.008 0.0761 0.1325
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0052 0.045 0.045
Loa Loa (eye worm) hypothetical protein 0.0195 0.2061 0.3771
Echinococcus granulosus single minded 2 0.011 0.1099 0.2038
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0052 0.045 0.0835
Schistosoma mansoni cpg binding protein 0.0032 0.0222 0.0364
Echinococcus multilocularis cpg binding protein 0.0034 0.0243 0.0243
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0022 0.0106 0.0131
Loa Loa (eye worm) hypothetical protein 0.011 0.1108 0.2026
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.011 0.1108 0.1108
Echinococcus granulosus netrin receptor unc 5 0.0016 0.0043 0.008
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0104 0.1984
Loa Loa (eye worm) hypothetical protein 0.0035 0.0255 0.0467
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0431 0.0716
Echinococcus multilocularis n acetylated alpha linked acidic dipeptidase 2 0.03 0.324 0.324
Brugia malayi Nuclear hormone receptor-like 1 0.0058 0.0521 0.0881
Loa Loa (eye worm) hypothetical protein 0.028 0.3015 0.5516
Giardia lamblia Histone acetyltransferase GCN5 0.0043 0.0352 1
Brugia malayi Nuclear hormone receptor E75 0.0052 0.045 0.0751
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.011 0.1108 0.1108
Echinococcus multilocularis dna polymerase eta 0.0021 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.002 0.0088 0.0161
Onchocerca volvulus 0.0067 0.0619 0.1072
Onchocerca volvulus 0.002 0.0088 0.0084
Leishmania major cytochrome p450-like protein 0.0048 0.0407 0.6686
Schistosoma mansoni single-minded 0.0148 0.1533 0.3021
Brugia malayi Steroid receptor seven-up type 2 0.011 0.1108 0.1963
Loa Loa (eye worm) ShTK domain-containing protein 0.0195 0.2061 0.3771
Brugia malayi EGF-like domain containing protein 0.0052 0.0453 0.0757
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0022 0.0106 0.0131
Loa Loa (eye worm) leucyl aminopeptidase 0.002 0.0088 0.0161
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.015 0.2427
Brugia malayi leucyl aminopeptidase 0.002 0.0088 0.0084
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0063 0.0575 0.1732
Loa Loa (eye worm) hypothetical protein 0.0195 0.2061 0.3771
Schistosoma mansoni nuclear receptor 0.0052 0.045 0.0826
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0022 0.0106 0.0131
Loa Loa (eye worm) hypothetical protein 0.011 0.1108 0.2026
Loa Loa (eye worm) tyrosinase 1 0.0195 0.2061 0.3771
Schistosoma mansoni aryl hydrocarbon receptor 0.0148 0.1533 0.3021
Loa Loa (eye worm) hypothetical protein 0.0035 0.0255 0.0467
Loa Loa (eye worm) hypothetical protein 0.0052 0.045 0.0824
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0039 0.0297 0.0297
Brugia malayi nuclear hormone receptor family member nhr-6 0.0052 0.045 0.0751
Schistosoma mansoni nuclear hormone receptor 0.011 0.1108 0.2158
Loa Loa (eye worm) hypothetical protein 0.0052 0.045 0.0824
Plasmodium falciparum histone acetyltransferase GCN5 0.0043 0.0352 1
Schistosoma mansoni RAR-like nuclear receptor 0.011 0.1108 0.2158
Loa Loa (eye worm) hypothetical protein 0.0035 0.0255 0.0467
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0043 0.0078
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0104 0.0256
Loa Loa (eye worm) hypothetical protein 0.0052 0.045 0.0824
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.011 0.1108 0.1108
Echinococcus granulosus retinoic acid receptor rxr beta a 0.011 0.1108 0.2053
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0022 0.0106 0.0131
Loa Loa (eye worm) hypothetical protein 0.0035 0.0255 0.0467
Echinococcus granulosus endoplasmic reticulum metallopeptidase 1 0.002 0.0088 0.0164
Loa Loa (eye worm) hypothetical protein 0.0204 0.2159 0.3949
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.011 0.1108 0.2158
Loa Loa (eye worm) hypothetical protein 0.0063 0.0569 0.1041
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0104 0.0191
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0022 0.0106 0.0131
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0022 0.0106 0.0131
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.011 0.1108 0.1108
Schistosoma mansoni hypothetical protein 0.01 0.0991 0.1923
Loa Loa (eye worm) hypothetical protein 0.0058 0.0521 0.0952
Echinococcus granulosus cytoplasmic intermediate filament protein 0.004 0.031 0.0575
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0435 0.0795
Loa Loa (eye worm) abnormal epIthelia family member 0.0052 0.0453 0.0829
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0104 0.1075
Brugia malayi Nuclear hormone receptor family member nhr-25 0.011 0.1108 0.1963
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0022 0.0106 0.1127
Loa Loa (eye worm) hypothetical protein 0.0491 0.5394 0.9868
Brugia malayi follicle stimulating hormone receptor 0.0484 0.5323 0.9735
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0255 0.3736
Onchocerca volvulus 0.01 0.0991 0.1766
Brugia malayi conserved hypotetical protein 0.0052 0.045 0.0751
Entamoeba histolytica hypothetical protein 0.0144 0.149 1
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0104 0.1984
Brugia malayi nicalin 0.002 0.0088 0.0084
Echinococcus granulosus slit 2 protein 0.0052 0.0453 0.0841
Echinococcus multilocularis FTZ F1 alpha 0.011 0.1108 0.1108
Brugia malayi hypothetical protein 0.0016 0.0049 0.001
Schistosoma mansoni hypothetical protein 0.0055 0.0486 0.0898
Echinococcus granulosus serotonin transporter 0.0067 0.0619 0.1147
Brugia malayi orphan nuclear receptor NR2E1 0.0052 0.045 0.0751
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.0569 0.919
Brugia malayi ecdysone receptor 0.0052 0.045 0.0751
Schistosoma mansoni thyroid hormone receptor 0.025 0.2681 0.5348
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0104 0.1984
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.011 0.1108 0.1108
Entamoeba histolytica acetyltransferase, GNAT family 0.0043 0.0352 0.1994
Leishmania major DNA polymerase eta, putative 0.0021 0.0104 0.0719
Echinococcus granulosus FTZ F1 alpha 0.011 0.1108 0.2053
Loa Loa (eye worm) hypothetical protein 0.0081 0.0772 0.1413
Loa Loa (eye worm) hypothetical protein 0.0025 0.015 0.0275
Echinococcus granulosus histone lysine methyltransferase setb 0.0063 0.0569 0.1055
Brugia malayi Nuclear hormone receptor family member nhr-14 0.011 0.1108 0.1963
Loa Loa (eye worm) hypothetical protein 0.004 0.031 0.0567
Brugia malayi nuclear receptor RXR 0.0052 0.045 0.0751
Echinococcus multilocularis nuclear receptor nhr 48 0.0052 0.045 0.045
Brugia malayi hypothetical protein 0.0491 0.5394 0.9867
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0068 0.1018
Loa Loa (eye worm) hypothetical protein 0.011 0.1108 0.2026
Echinococcus multilocularis aryl hydrocarbon receptor 0.0039 0.0297 0.0297
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0251 0.0384
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0022 0.0106 0.0131
Echinococcus multilocularis slit 2 protein 0.0052 0.0453 0.0453
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0255 0.598
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0022 0.0106 0.0131
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0022 0.0106 0.0131
Brugia malayi Ets-domain containing protein 0.008 0.0768 0.1338
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0058 0.0521 0.0965
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0068 0.5
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0063 0.0575 1
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0039 0.0297 0.4521
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.0536 0.0993
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0255 0.064
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0255 0.0473
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0255 0.064
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0104 0.1984
Mycobacterium tuberculosis Conserved protein 0.0035 0.0255 0.064
Brugia malayi beta-lactamase 0.0035 0.0255 0.0392
Trypanosoma cruzi glutaminyl cyclase, putative 0.002 0.0088 0.0596
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0039 0.0297 0.6763
Echinococcus multilocularis survival motor neuron protein 1 0.0491 0.5394 0.5394
Echinococcus multilocularis GPCR, family 2 0.0016 0.0043 0.0043
Brugia malayi Nuclear hormone receptor family member nhr-19 0.011 0.1108 0.1963
Leishmania major hypothetical protein, conserved 0.0035 0.0255 0.3693
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0528 0.157
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0022 0.0106 0.0131
Echinococcus granulosus intermediate filament protein 0.0082 0.0789 0.1463
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0104 0.0114
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0022 0.0106 0.0753
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0195 0.2061 0.3722
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0052 0.045 0.0826
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0039 0.0297 0.6763
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0528 0.9065
Brugia malayi Cytochrome P450 family protein 0.0048 0.0407 0.0671
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0022 0.0106 0.0131
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0255 0.0431
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0528 0.157
Brugia malayi ShTK domain containing protein 0.0195 0.2061 0.3722
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0022 0.0106 0.0131
Trichomonas vaginalis set domain proteins, putative 0.0492 0.5412 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0433 0.4739 0.8669
Schistosoma mansoni tyrosinase precursor 0.0195 0.2061 0.4091
Brugia malayi hypothetical protein 0.0058 0.0521 0.0881
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0039 0.0297 0.6763
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.011 0.1108 0.1963
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0063 0.0575 0.1732
Schistosoma mansoni steroid hormone receptor ad4bp 0.011 0.1108 0.2158
Onchocerca volvulus 0.0052 0.045 0.0758
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0449 0.0821
Mycobacterium ulcerans lipoprotein aminopeptidase LpqL 0.0027 0.0171 0.035
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0022 0.0106 0.0131
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.011 0.1108 0.2053
Brugia malayi bZIP transcription factor family protein 0.0259 0.278 0.5047
Brugia malayi hypothetical protein 0.0025 0.015 0.0198
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0161 0.1675 0.1675
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0104 0.0125
Echinococcus multilocularis serotonin transporter 0.0067 0.0619 0.0619
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0297 0.0429
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.011 0.1108 0.1963
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0222 0.2368 0.7857
Brugia malayi Cytochrome P450 family protein 0.0022 0.0106 0.0117
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0104 0.1984
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0255 0.035
Brugia malayi bHLH-PAS transcription factor 0.011 0.1099 0.1948
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0063 0.0575 0.0575
Echinococcus granulosus Nuclear hormone receptor HR96 0.0052 0.045 0.0835
Brugia malayi Common central domain of tyrosinase family protein 0.0195 0.2061 0.3722
Echinococcus granulosus nuclear factor of activated T cells 5 0.0082 0.0784 0.1453
Schistosoma mansoni nicalin (M28 family) 0.002 0.0088 0.0092
Onchocerca volvulus Fxna peptidase homolog 0.002 0.0088 0.0084
Loa Loa (eye worm) intermediate filament protein 0.0082 0.0789 0.1444
Schistosoma mansoni cpg binding protein 0.0034 0.0243 0.0405
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0104 0.1075
Echinococcus multilocularis dnaJ subfamily B 0.0454 0.4976 0.4976
Echinococcus granulosus lamin 0.0082 0.0789 0.1463
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0104 0.1075
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0104 0.0125
Loa Loa (eye worm) hypothetical protein 0.0027 0.0164 0.03
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.011 0.1108 0.2158
Giardia lamblia DINP protein human, muc B family 0.0021 0.0104 0.1285
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0067 0.0619 0.1168
Loa Loa (eye worm) hypothetical protein 0.0052 0.045 0.0824
Schistosoma mansoni thyroid hormone receptor 0.025 0.2681 0.5348
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0435 0.0435
Onchocerca volvulus 0.0035 0.0255 0.0395
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.011 0.1108 0.2026
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0022 0.0106 0.0131
Brugia malayi nuclear receptor NHR-67 0.0052 0.045 0.0751
Toxoplasma gondii ABC1 family protein 0.0035 0.0255 0.3433
Onchocerca volvulus 0.0195 0.2061 0.3759
Trypanosoma brucei glutaminyl cyclase, putative 0.002 0.0088 0.1553
Leishmania major hypothetical protein, conserved 0.002 0.0088 0.0398
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0067 0.0619 0.1062
Schistosoma mansoni gabp alpha 0.008 0.0768 0.1471
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0016 0.0043 0.008
Loa Loa (eye worm) hypothetical protein 0.0039 0.0297 0.0544
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0255 0.064
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0255 0.5524
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0058 0.0521 0.0968
Brugia malayi hypothetical protein 0.0052 0.045 0.0751
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0022 0.0106 0.0131
Leishmania major cytochrome p450-like protein 0.0022 0.0106 0.0753
Echinococcus granulosus nuclear receptor 2DBD gamma 0.011 0.1108 0.2053
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0052 0.045 0.045
Loa Loa (eye worm) hypothetical protein 0.0067 0.0619 0.1132
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0082 0.0784 0.0784
Loa Loa (eye worm) hypothetical protein 0.0038 0.0293 0.0536
Onchocerca volvulus 0.0492 0.5413 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.0619 0.1132
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0052 0.045 0.045
Loa Loa (eye worm) DR-78 0.0052 0.045 0.0824
Loa Loa (eye worm) cytochrome P450 family protein 0.008 0.0761 0.1393
Loa Loa (eye worm) nuclear hormone receptor 0.0052 0.045 0.0824
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0039 0.0297 0.0551
Brugia malayi FXNA 0.002 0.0088 0.0084
Schistosoma mansoni lamin 0.0082 0.0789 0.1513
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0047 0.0396 0.0614
Echinococcus granulosus cpg binding protein 0.0034 0.0243 0.045
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0022 0.0106 0.0131
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0144 0.149 0.2763
Echinococcus granulosus lamin dm0 0.0082 0.0789 0.1463
Brugia malayi beta-lactamase family protein 0.0035 0.0255 0.0392
Echinococcus granulosus survival motor neuron protein 1 0.0491 0.5394 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.01 0.0991 0.1749
Treponema pallidum sodium- and chloride- dependent transporter 0.0067 0.0619 1
Onchocerca volvulus Glutaminyl cyclase homolog 0.002 0.0088 0.0084
Brugia malayi beta-lactamase family protein 0.0035 0.0255 0.0392
Schistosoma mansoni transcription factor LCR-F1 0.0144 0.149 0.2934
Trypanosoma brucei unspecified product 0.0021 0.0104 0.1984
Brugia malayi hypothetical protein 0.0052 0.045 0.0751
Entamoeba histolytica hypothetical protein 0.0144 0.149 1
Toxoplasma gondii peptidase, M28 family protein 0.002 0.0088 0.037
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0528 0.0528
Brugia malayi nuclear receptor NHR-88 0.011 0.1108 0.1963
Onchocerca volvulus 0.011 0.1099 0.1967
Onchocerca volvulus 0.0052 0.045 0.0758
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0022 0.0106 0.0131
Echinococcus multilocularis Ankyrin 0.0016 0.0044 0.0044
Loa Loa (eye worm) cytochrome P450 family protein 0.0048 0.0407 0.0745
Brugia malayi Intermediate filament tail domain containing protein 0.0082 0.0789 0.1376
Schistosoma mansoni NAALADASE L peptidase (M28 family) 0.0196 0.2076 0.4121
Brugia malayi steroid hormone receptor 0.011 0.1108 0.1963
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0255 0.035
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0063 0.0575 0.0981
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0104 0.0125
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0435 0.0806
Loa Loa (eye worm) hypothetical protein 0.0052 0.0453 0.0829
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0039 0.0297 0.6763
Trichomonas vaginalis guanylate cyclase, putative 0.0039 0.0297 0.0429
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.015 0.2901
Trichomonas vaginalis Clan MH, family M28, aminopeptidase S-like metallopeptidase 0.002 0.0088 0.0038
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0104 0.0068
Loa Loa (eye worm) hypothetical protein 0.0052 0.0453 0.0829
Onchocerca volvulus Bile acid receptor homolog 0.011 0.1108 0.1983
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0297 0.0429
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0039 0.0297 0.6763
Echinococcus multilocularis lamin 0.0082 0.0789 0.0789
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0528 0.0983
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0104 0.1984
Schistosoma mansoni DNA polymerase eta 0.0021 0.0104 0.0125
Brugia malayi hypothetical protein 0.0144 0.149 0.2669
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0255 0.0392
Mycobacterium ulcerans putative regulatory protein 0.011 0.1099 0.3523
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0104 0.1984
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0016 0.0043 0.0043
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0484 0.5323 0.9737
Schistosoma mansoni laminin gamma-3 chain 0.0052 0.0453 0.0832
Loa Loa (eye worm) hypothetical protein 0.0067 0.0619 0.1132
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.015 0.3198
Echinococcus multilocularis 0.0022 0.0106 0.0106
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0058 0.0521 0.0521
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0255 0.064
Brugia malayi acetyltransferase, GNAT family protein 0.0161 0.1675 0.3009
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0104 0.0719
Onchocerca volvulus 0.0082 0.0789 0.1389
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0063 0.0575 0.1066
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0104 0.1984
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0104 0.1984
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0255 0.035
Onchocerca volvulus 0.0195 0.2061 0.3759
Loa Loa (eye worm) hypothetical protein 0.0082 0.0789 0.1444
Schistosoma mansoni hypothetical protein 0.021 0.2234 0.4441
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0255 0.064
Loa Loa (eye worm) fli-1 protein 0.0244 0.2612 0.4777
Loa Loa (eye worm) hypothetical protein 0.011 0.1108 0.2026
Schistosoma mansoni intermediate filament proteins 0.0082 0.0789 0.1513
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0255 0.5524
Echinococcus multilocularis neurogenic locus notch protein 0.0052 0.0453 0.0453
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0528 0.157
Echinococcus multilocularis netrin receptor unc 5 0.0016 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0052 0.045 0.0824
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0039 0.0297 0.0429
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0255 0.035
Schistosoma mansoni nuclear hormone receptor 0.0052 0.045 0.0826
Echinococcus granulosus nuclear receptor nhr 48 0.0052 0.045 0.0835
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0022 0.0106 0.0131
Loa Loa (eye worm) CYP4Cod1 0.0048 0.0407 0.0745
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0068 0.0124
Brugia malayi nuclear receptor NHR-88 0.0052 0.045 0.0751
Echinococcus multilocularis musashi 0.0082 0.0789 0.0789
Echinococcus granulosus jun protein 0.0259 0.278 0.5154
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0048 0.0407 0.1158
Onchocerca volvulus 0.0032 0.0222 0.0334
Brugia malayi Peptidase family M28 containing protein 0.002 0.0088 0.0084
Loa Loa (eye worm) hypothetical protein 0.0052 0.045 0.0824
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0022 0.0106 0.0131
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0052 0.045 0.0751
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0063 0.0569 0.0569

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 85 % Inhibition of TNFalpha-induced necroptosis in FADD-deficient Jurkat T cells ChEMBL. 17270434
Activity (functional) = 85 % Inhibition of TNFalpha-induced necroptosis in FADD-deficient Jurkat T cells ChEMBL. 17270434
EC50 (functional) = 2.22 uM Inhibition of TNFalpha-induced necroptosis in FADD-deficient Jurkat T cells ChEMBL. 17270434
EC50 (functional) = 2.22 uM Inhibition of TNFalpha-induced necroptosis in FADD-deficient Jurkat T cells ChEMBL. 17270434

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 17270434

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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