Detailed information for compound 510494

Basic information

Technical information
  • TDR Targets ID: 510494
  • Name: 2-(3-iodophenyl)-N-[(3S)-2-oxooxolan-3-yl]ace tamide
  • MW: 345.133 | Formula: C12H12INO3
  • H donors: 1 H acceptors: 2 LogP: 1.87 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N[C@H]1CCOC1=O)Cc1cccc(c1)I
  • InChi: 1S/C12H12INO3/c13-9-3-1-2-8(6-9)7-11(15)14-10-4-5-17-12(10)16/h1-3,6,10H,4-5,7H2,(H,14,15)/t10-/m0/s1
  • InChiKey: KBUNROHADPJPKR-JTQLQIEISA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(3-iodophenyl)-N-[(3S)-2-oxotetrahydrofuran-3-yl]acetamide
  • 2-(3-iodophenyl)-N-[(3S)-2-oxo-3-tetrahydrofuranyl]acetamide
  • 2-(3-iodophenyl)-N-[(3S)-2-oxooxolan-3-yl]ethanamide
  • 2-(3-iodophenyl)-N-[(3S)-2-ketotetrahydrofuran-3-yl]acetamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0182 0.0704
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0018 0.012 0.0465
Leishmania major ATP-dependent phosphofructokinase 0.0107 0.1242 0.9486
Leishmania major alpha tubulin 0.0055 0.0587 0.4373
Loa Loa (eye worm) DNA-directed DNA polymerase III 0.0015 0.008 0.0308
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.0182 0.0972
Brugia malayi cyclin fold protein 1 variant b 0.002 0.014 0.0508
Giardia lamblia Beta tubulin 0.0062 0.0673 0.4832
Giardia lamblia DNA polymerase alpha subunit A 0.0047 0.048 0.326
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0188 0.0647
Loa Loa (eye worm) tubulin alpha-2 chain 0.0055 0.0587 0.2269
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0266 0.0256
Brugia malayi isocitrate dehydrogenase 0.0016 0.0083 0.0287
Brugia malayi DNA polymerase family B containing protein 0.0015 0.008 0.0274
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.0065 0.0251
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0125 0.0116
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0266 0.0282
Trichomonas vaginalis cyclin B, putative 0.0112 0.1307 0.4582
Trypanosoma brucei DNA polymerase epsilon catalytic subunit, putative 0.0015 0.008 0.0404
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0112 0.1307 1
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0252 0.0872
Echinococcus granulosus tubulin beta 1 chain 0.0062 0.0673 0.0781
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0252 0.3645
Schistosoma mansoni cyclin k 0.002 0.014 0.0134
Leishmania major alpha tubulin 0.0055 0.0587 0.4373
Schistosoma mansoni cpg binding protein 0.003 0.0264 0.0281
Trichomonas vaginalis tubulin beta chain, putative 0.0055 0.0587 0.2052
Trichomonas vaginalis tubulin, putative 0.0021 0.0146 0.0499
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0125 0.0482
Echinococcus granulosus death domain containing protein 0.0014 0.0065 0.0065
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0266 0.0282
Leishmania major beta tubulin 0.0062 0.0673 0.5041
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0024 0.0186 0.0685
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0676 0.2585
Echinococcus granulosus Tubulin alpha 1 chain 0.0055 0.0587 0.068
Trypanosoma brucei mitotic cyclin 6 0.0112 0.1307 1
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.0572 0.2211
Trypanosoma brucei zeta tubulin, putative 0.0021 0.0146 0.0921
Echinococcus granulosus cyclins 0.002 0.014 0.0153
Trypanosoma brucei alpha tubulin 0.0055 0.0587 0.4373
Trichomonas vaginalis cyclin B3, putative 0.002 0.014 0.0478
Trichomonas vaginalis DNA polymerase II, putative 0.0024 0.0192 0.0662
Mycobacterium leprae cell division protein FtsZ 0.0021 0.0146 0.0591
Leishmania major beta tubulin 0.0062 0.0673 0.5041
Echinococcus multilocularis tubulin alpha 0.0047 0.0485 0.0475
Echinococcus multilocularis beta tubulin 0.0062 0.0673 0.0663
Echinococcus multilocularis beta tubulin 0.0062 0.0673 0.0663
Schistosoma mansoni intermediate filament proteins 0.0054 0.0568 0.064
Brugia malayi Tubulin alpha-2 chain 0.0055 0.0587 0.2242
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.009 0.0167
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.1231 0.8857
Loa Loa (eye worm) hypothetical protein 0.0149 0.1771 0.6838
Echinococcus granulosus tubulin alpha 1C chain 0.0055 0.0587 0.068
Echinococcus granulosus DNA polymerase delta catalytic subunit 0.0015 0.008 0.0082
Echinococcus granulosus cyclin A3 4 0.002 0.014 0.0153
Trypanosoma cruzi tubulin delta chain 0.0021 0.0146 0.0921
Trypanosoma cruzi cyclin, putative 0.0112 0.1307 1
Toxoplasma gondii DNA polymerase (pol2) superfamily protein 0.0045 0.0455 0.6624
Plasmodium falciparum glutathione reductase 0.0016 0.009 0.0122
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0446 0.327
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0446 0.1724
Mycobacterium tuberculosis Probable reductase 0.0106 0.1231 0.8857
Brugia malayi DNA polymerase delta catalytic subunit 0.0015 0.008 0.0274
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.0622 0.0721
Trichomonas vaginalis cyclins, putative 0.002 0.014 0.0478
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.1242 0.4351
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0503 0.0562
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0021 0.0146 0.2084
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0027 0.0017
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0014 0.0068 0.0314
Echinococcus granulosus Tubulin alpha 1 chain 0.0055 0.0587 0.068
Loa Loa (eye worm) hypothetical protein 0.0035 0.0327 0.1264
Plasmodium vivax delta tubulin, putative 0.0021 0.0146 0.1319
Trichomonas vaginalis cyclins, putative 0.0112 0.1307 0.4582
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0125 0.0135
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.009 0.0187
Loa Loa (eye worm) RNA binding protein 0.0062 0.0676 0.261
Leishmania major beta tubulin 0.0062 0.0673 0.5041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0364 0.1267
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0125 0.0115
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0146 0.0499
Onchocerca volvulus 0.003 0.0266 0.0721
Echinococcus granulosus cyclins 0.0083 0.0939 0.1095
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.1242 0.9486
Brugia malayi phosphofructokinase 0.0107 0.1242 0.4777
Giardia lamblia Cyclin fold protein 1, putative 0.002 0.014 0.0491
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0036 0.0105
Trichomonas vaginalis tubulin epsilon chain, putative 0.0055 0.0587 0.2052
Toxoplasma gondii alpha tubulin TUBA1 0.0055 0.0587 0.8571
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0476 0.3499
Loa Loa (eye worm) hypothetical protein 0.0029 0.0249 0.096
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0266 0.0256
Trichomonas vaginalis cyclin B, putative 0.0112 0.1307 0.4582
Leishmania major alpha tubulin 0.0055 0.0587 0.4373
Onchocerca volvulus DNA polymerase epsilon catalytic subunit A homolog 0.0015 0.008 0.0052
Echinococcus multilocularis cyclin y 0.002 0.014 0.013
Loa Loa (eye worm) alpha-tubulin 0.0055 0.0587 0.2269
Echinococcus multilocularis cyclin y 0.002 0.014 0.013
Plasmodium vivax DNA polymerase zeta catalytic subunit, putative 0.0015 0.008 0.0229
Trichomonas vaginalis tubulin epsilon chain, putative 0.0021 0.0146 0.0499
Echinococcus multilocularis cyclin 0.002 0.014 0.013
Echinococcus granulosus microtubule associated protein 2 0.0681 0.8493 1
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0083 0.0037
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.009 0.0075
Brugia malayi hypothetical protein 0.0025 0.02 0.0741
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.2489 0.9614
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0125 0.0135
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0252 0.1404
Trichomonas vaginalis tubulin epsilon chain, putative 0.0062 0.0673 0.2352
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0676 0.0767
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0303 0.105
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0125 0.0115
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0214 0.2589 0.304
Loa Loa (eye worm) beta-tubulin 0.0062 0.0673 0.2598
Echinococcus multilocularis netrin receptor unc 5 0.0014 0.0065 0.0055
Entamoeba histolytica hypothetical protein 0.0035 0.0335 0.2396
Echinococcus multilocularis tubulin gamma 1 chain 0.0047 0.0485 0.0475
Echinococcus multilocularis cdk5 and abl1 enzyme substrate 1 0.002 0.014 0.013
Schistosoma mansoni tubulin subunit gamma 0.0047 0.0485 0.0541
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0252 1
Trichomonas vaginalis DNA helicase recq, putative 0.0011 0.0028 0.0085
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0182 0.1206
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0107 0.1242 0.8936
Brugia malayi hypothetical protein 0.0019 0.0125 0.0449
Trypanosoma brucei epsilon tubulin 0.0047 0.0485 0.357
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0262 0.0907
Echinococcus multilocularis cyclin b3 0.0083 0.0939 0.093
Giardia lamblia Alpha-tubulin 0.0055 0.0587 0.4137
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0125 0.0425
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0188 0.0649
Trichomonas vaginalis cyclin B, putative 0.002 0.014 0.0478
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0251 0.0971
Schistosoma mansoni tubulin subunit alpha 0.0055 0.0587 0.0662
Loa Loa (eye worm) tubulin alpha 2 0.0035 0.0327 0.1264
Echinococcus multilocularis dna polymerase epsilon catalytic subunit a 0.0015 0.008 0.0069
Echinococcus granulosus Ankyrin 0.0014 0.0067 0.0066
Leishmania major beta tubulin 0.0062 0.0673 0.5041
Toxoplasma gondii cyclin, N-terminal domain-containing protein 0.002 0.014 0.1998
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0074 0.0251
Schistosoma mansoni tubulin subunit delta 0.0021 0.0146 0.0141
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0446 0.1555
Echinococcus granulosus lamin 0.0054 0.0568 0.0658
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0188 0.0647
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0446 0.327
Leishmania major alpha tubulin 0.0055 0.0587 0.4373
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0251
Leishmania major alpha tubulin 0.0055 0.0587 0.4373
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.1242 0.9486
Plasmodium vivax cyclin dependent kinase binding protein, putative 0.002 0.014 0.1222
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0083 0.0085
Brugia malayi Cytochrome P450 family protein 0.0014 0.0068 0.023
Trypanosoma brucei alpha tubulin 0.0055 0.0587 0.4373
Leishmania major beta tubulin 0.0062 0.0673 0.5041
Toxoplasma gondii cyclin dependent kinase binding protein 0.002 0.014 0.1998
Trichomonas vaginalis cyclin B, putative 0.0083 0.0939 0.3287
Trichomonas vaginalis cyclin B3, putative 0.002 0.014 0.0478
Schistosoma mansoni Cyclin fold protein 0.002 0.014 0.0134
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0118 0.1381 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0332 0.2377
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0125 0.0425
Trichomonas vaginalis tubulin beta chain, putative 0.0055 0.0587 0.2052
Trichomonas vaginalis tubulin alpha chain, putative 0.0047 0.0485 0.169
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.1231 0.8857
Plasmodium falciparum thioredoxin reductase 0.0016 0.009 0.0122
Echinococcus multilocularis tubulin alpha 1C chain 0.0055 0.0587 0.0578
Echinococcus granulosus tubulin alpha 1C chain 0.0055 0.0587 0.068
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.009 0.0486
Echinococcus granulosus cyclin b3 0.0083 0.0939 0.1095
Trypanosoma cruzi CYC2-like cyclin, putative 0.0112 0.1307 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0083 0.032
Toxoplasma gondii beta-1 tubulin, putative 0.0062 0.0673 0.9824
Echinococcus granulosus G1:S specific cyclin D1 0.002 0.014 0.0153
Plasmodium falciparum glutathione reductase 0.0047 0.0476 0.4607
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0058 0.0622 0.2376
Trypanosoma cruzi cyclin, putative 0.0112 0.1307 1
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0214 0.2589 0.2582
Brugia malayi Pre-SET motif family protein 0.003 0.0266 0.0996
Echinococcus multilocularis tubulin alpha 3 chain 0.0055 0.0587 0.0578
Echinococcus multilocularis cyclins 0.0083 0.0939 0.093
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.009 0.0122
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0125 0.0115
Loa Loa (eye worm) hypothetical protein 0.0049 0.0508 0.196
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.1242 0.4351
Echinococcus granulosus tubulin alpha chain 0.0055 0.0587 0.068
Echinococcus multilocularis hypothetical protein 0.0055 0.0587 0.0578
Echinococcus granulosus geminin 0.0167 0.1999 0.2345
Schistosoma mansoni lamin 0.0054 0.0568 0.064
Trypanosoma brucei alpha tubulin 0.0055 0.0587 0.4373
Echinococcus granulosus cyclin G2 0.002 0.014 0.0153
Trypanosoma cruzi beta tubulin, putative 0.0062 0.0673 0.5041
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0151 0.0961
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0332 0.1152
Trichomonas vaginalis tubulin beta chain, putative 0.0027 0.0225 0.0776
Loa Loa (eye worm) hypothetical protein 0.0019 0.0125 0.0482
Schistosoma mansoni cyclin B3 0.0214 0.2589 0.3027
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0446 0.0436
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.02 0.1346
Loa Loa (eye worm) hypothetical protein 0.0053 0.0556 0.2146
Brugia malayi 6-phosphofructokinase 0.0107 0.1242 0.4777
Plasmodium vivax tubulin epsilon chain, putative 0.0047 0.0485 0.6901
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0252 0.1752
Schistosoma mansoni hypothetical protein 0.0016 0.0083 0.0066
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0446 0.327
Echinococcus granulosus peroxisome assembly protein 26 0.0055 0.0587 0.068
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0065 0.0055
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0578 0.8434
Brugia malayi Cyclin, N-terminal domain containing protein 0.002 0.014 0.0508
Loa Loa (eye worm) cytochrome P450 0.0014 0.0068 0.0263
Echinococcus multilocularis cyclin B 0.0112 0.1307 0.1298
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.002 0.014 0.013
Echinococcus multilocularis cyclin B3 1 0.0083 0.0939 0.093
Schistosoma mansoni lamin 0.0054 0.0568 0.064
Echinococcus multilocularis peroxisome assembly protein 26 0.0055 0.0587 0.0578
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0303 0.4388
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.1231 0.8857
Trypanosoma cruzi tubulin delta chain 0.0021 0.0146 0.0921
Echinococcus multilocularis Tubulin beta 2C chain 0.0062 0.0673 0.0663
Schistosoma mansoni tubulin subunit alpha 0.0055 0.0587 0.0662
Echinococcus granulosus Cyclin L1 0.002 0.014 0.0153
Echinococcus granulosus tubulin alpha chain 0.0055 0.0587 0.068
Echinococcus granulosus netrin receptor unc 5 0.0014 0.0065 0.0065
Toxoplasma gondii beta-tubulin, putative 0.0062 0.0673 0.9824
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0476 0.3102
Loa Loa (eye worm) hypothetical protein 0.0025 0.0203 0.0783
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.009 0.0303
Plasmodium vivax DNA polymerase delta catalytic subunit, putative 0.0015 0.008 0.0229
Trichomonas vaginalis tubulin alpha chain, putative 0.0062 0.0673 0.2352
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0221 0.0762
Schistosoma mansoni alpha tubulin 0.0055 0.0587 0.0662
Trypanosoma brucei zeta tubulin 0.0021 0.0146 0.0921
Leishmania major phosphatidylinositol 3-kinase, putative 0.0015 0.0074 0.0358
Echinococcus granulosus cyclins 0.0083 0.0939 0.1095
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0083 0.0073
Trypanosoma brucei mitotic cyclin 0.002 0.014 0.0875
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0064 0.0877
Echinococcus multilocularis dnaJ subfamily B 0.0403 0.4987 0.4982
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.009 0.0486
Trichomonas vaginalis cyclin D, putative 0.0083 0.0939 0.3287
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0125 0.0425
Onchocerca volvulus 0.0054 0.0568 0.1807
Echinococcus multilocularis cyclin A3 4 0.002 0.014 0.013
Giardia lamblia Hypothetical protein 0.002 0.014 0.0491
Echinococcus granulosus tubulin subunit TubB 0.0055 0.0587 0.068
Schistosoma mansoni hypothetical protein 0.0034 0.0311 0.0335
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0125 0.0425
Echinococcus multilocularis microtubule associated protein 2 0.0681 0.8493 0.8491
Trichomonas vaginalis cyclin D, putative 0.0083 0.0939 0.3287
Giardia lamblia G2/mitotic-specific cyclin B 0.0112 0.1307 1
Leishmania major cytochrome p450-like protein 0.0023 0.0182 0.1206
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0125 0.0116
Echinococcus granulosus tubulin alpha chain 0.0055 0.0587 0.068
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0303 0.105
Brugia malayi DNA polymerase family B, exonuclease domain containing protein 0.0015 0.008 0.0274
Brugia malayi hypothetical protein 0.002 0.014 0.0508
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0266 0.3848
Echinococcus multilocularis cyclin t1 0.002 0.014 0.013
Schistosoma mansoni DNA polymerase zeta catalytic subunit 0.0015 0.008 0.0062
Brugia malayi Tubulin beta-1 chain 0.0062 0.0673 0.2573
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.002 0.014 0.0701
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.009 0.0486
Echinococcus multilocularis Tubulin alpha 1 chain 0.0055 0.0587 0.0578
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0215 0.0205
Trypanosoma brucei beta tubulin 0.0062 0.0673 0.5041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0074 0.0246
Toxoplasma gondii cyclin domain protein, cyclin H family protein 0.002 0.014 0.1998
Schistosoma mansoni tubulin subunit beta 0.0062 0.0673 0.0763
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0125 0.0116
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0015 0.008 0.0404
Plasmodium vivax cyclin 4, putative 0.002 0.014 0.1222
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0252 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0015
Trypanosoma cruzi DNA polymerase I alpha catalytic subunit, putative 0.0024 0.0192 0.1283
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0125 0.0115
Echinococcus multilocularis Tubulin beta 2C chain 0.0062 0.0673 0.0663
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0125 0.0116
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0029 0.0249 0.086
Echinococcus multilocularis tubulin subunit TubB 0.0055 0.0587 0.0578
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0332 0.2377
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0125 0.0116
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0125 0.0135
Brugia malayi Cyclin C 0.002 0.014 0.0508
Leishmania major delta tubulin, putative 0.0021 0.0146 0.0921
Leishmania major alpha tubulin 0.0055 0.0587 0.4373
Leishmania major cyclin 0.0112 0.1307 1
Plasmodium vivax tubulin beta chain, putative 0.0062 0.0673 1
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0568 0.2168
Brugia malayi Uncoordinated protein 44 0.0014 0.0065 0.0218
Entamoeba histolytica cyclin C, putative 0.002 0.014 0.0875
Echinococcus granulosus tubulin alpha 3 chain 0.0055 0.0587 0.068
Giardia lamblia Gamma tubulin 0.0047 0.0485 0.3299
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0182 0.0704
Brugia malayi Cell division protein ftsZ 0.0021 0.0146 0.0531
Trypanosoma cruzi alpha tubulin, putative 0.0055 0.0587 0.4373
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0062 0.0673 0.0663
Echinococcus multilocularis cyclins 0.0083 0.0939 0.093
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.1231 0.8857
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.009 0.0315
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0125 0.0115
Entamoeba histolytica hypothetical protein 0.0035 0.0335 0.2396
Brugia malayi Cyclin, N-terminal domain containing protein 0.002 0.014 0.0508
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.009 0.1267
Entamoeba histolytica cyclin, putative 0.0112 0.1307 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.02 0.1403
Leishmania major zeta tubulin, putative 0.0021 0.0146 0.0921
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0118 0.1381 1
Trypanosoma cruzi epsilon tubulin, putative 0.0047 0.0485 0.357
Giardia lamblia Epsilon tubulin 0.0021 0.0146 0.0539
Loa Loa (eye worm) glutathione reductase 0.0047 0.0476 0.1837
Echinococcus granulosus lamin dm0 0.0054 0.0568 0.0658
Loa Loa (eye worm) cyclin domain-containing protein 0.002 0.014 0.054
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0332 0.1152
Brugia malayi PXA domain containing protein 0.0019 0.0125 0.0449
Echinococcus multilocularis GPCR, family 2 0.0016 0.0083 0.0072
Schistosoma mansoni hypothetical protein 0.0014 0.0065 0.0045
Trypanosoma brucei epsilon tubulin 0.0047 0.0485 0.357
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0021 0.0149 0.0144
Trypanosoma cruzi cyclin 9, putative 0.002 0.014 0.0875
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0125 0.0135
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0215 0.0241
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.009 0.0486
Brugia malayi laminin-like protein K08C7.3 precursor 0.0024 0.0186 0.0685
Trypanosoma brucei trypanothione reductase 0.0047 0.0476 0.3499
Schistosoma mansoni hypothetical protein 0.0016 0.0083 0.0066
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.1242 0.9486
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.025 0.0864
Entamoeba histolytica tubulin gamma chain 0.0047 0.0485 0.357
Entamoeba histolytica cyclin, domain containing protein 0.002 0.014 0.0875
Toxoplasma gondii DNA polymerase 0.0015 0.008 0.1112
Brugia malayi Cyclin, N-terminal domain containing protein 0.002 0.014 0.0508
Brugia malayi PXA domain containing protein 0.0019 0.0125 0.0449
Echinococcus granulosus slit 2 protein 0.0024 0.0186 0.0207
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0.0074 0.0075
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0083 0.0072
Loa Loa (eye worm) cyclin domain-containing protein 0.002 0.014 0.054
Treponema pallidum cell division protein FtsZ 0.0021 0.0146 0.0483
Onchocerca volvulus 0.0149 0.1771 0.6125
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0083 0.0429
Brugia malayi TAR-binding protein 0.0062 0.0676 0.2585
Loa Loa (eye worm) RecQ helicase 0.0021 0.0152 0.0587
Brugia malayi Cyclin, N-terminal domain containing protein 0.002 0.014 0.0508
Echinococcus multilocularis Ankyrin 0.0014 0.0067 0.0056
Loa Loa (eye worm) cyclin domain-containing protein 0.0214 0.2589 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0446 0.327
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0252 0.0872
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.009 0.0122
Onchocerca volvulus 0.0049 0.0503 0.1571
Giardia lamblia Beta tubulin 0.0062 0.0673 0.4832
Loa Loa (eye worm) hypothetical protein 0.0016 0.0083 0.0319
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0083 0.0285
Trypanosoma brucei beta tubulin 0.0047 0.0485 0.357
Brugia malayi Cytochrome P450 family protein 0.0023 0.0182 0.0672
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0014 0.0068 0.0314
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0252 0.3645
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0015 0.0074 0.0358
Loa Loa (eye worm) tubulin alpha-3 chain 0.0029 0.0249 0.096
Echinococcus multilocularis tubulin beta 1 chain 0.0062 0.0673 0.0663
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0074 0.0246
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0476 0.6751
Loa Loa (eye worm) tubulin alpha chain 0.0055 0.0587 0.2269
Brugia malayi CXXC zinc finger family protein 0.0028 0.0244 0.0911
Brugia malayi Tubulin alpha-2 chain 0.0055 0.0587 0.2242
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0188 0.0649
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0125 0.0116
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0303 0.105
Echinococcus multilocularis tubulin alpha chain 0.0055 0.0587 0.0578
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0244 0.0276
Brugia malayi hypothetical protein 0.002 0.014 0.0508
Schistosoma mansoni cyclin B 0.0112 0.1307 0.1512
Loa Loa (eye worm) hypothetical protein 0.0019 0.0125 0.0482
Entamoeba histolytica tubulin alpha-1 chain 0.0055 0.0587 0.4373
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0244 0.0942
Loa Loa (eye worm) tubulin beta chain 0.0021 0.0146 0.0563
Toxoplasma gondii cytochrome p450 superfamily protein 0.0014 0.0068 0.0944
Trichomonas vaginalis tubulin beta chain, putative 0.0055 0.0587 0.2052
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0125 0.0449
Entamoeba histolytica hypothetical protein 0.0019 0.0125 0.0757
Brugia malayi Cyclin, N-terminal domain containing protein 0.002 0.014 0.0508
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0125 0.0425
Trichomonas vaginalis cyclin B, putative 0.002 0.014 0.0478
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0252 0.0872
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.009 0.0486
Leishmania major beta tubulin 0.0062 0.0673 0.5041
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0125 0.0135
Plasmodium vivax DNA polymerase epsilon, catalytic subunit a, putative 0.0015 0.008 0.0229
Mycobacterium tuberculosis Cell division protein FtsZ 0.0021 0.0146 0.0591
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0083 0.0073
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0125 0.0116
Giardia lamblia Hypothetical protein 0.002 0.014 0.0491
Trichomonas vaginalis tubulin, putative 0.0027 0.0225 0.0776
Trypanosoma cruzi epsilon tubulin, putative 0.0047 0.0485 0.357
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.014 0.0875
Trypanosoma brucei cyclin 3 0.002 0.014 0.0875
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0125 0.0482
Brugia malayi Cytochrome P450 family protein 0.0023 0.0182 0.0672
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0446 0.327
Brugia malayi Thioredoxin reductase 0.0047 0.0476 0.1808
Brugia malayi Tubulin beta chain 0.0027 0.0225 0.0836
Onchocerca volvulus Cyclin L homolog 0.002 0.014 0.0269
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0188 0.0649
Trichomonas vaginalis tubulin alpha chain, putative 0.0027 0.0225 0.0776
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.009 0.0486
Schistosoma mansoni hypothetical protein 0.002 0.014 0.0134
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0182 0.0704
Loa Loa (eye worm) hypothetical protein 0.0034 0.0311 0.12
Loa Loa (eye worm) hypothetical protein 0.0076 0.085 0.3283
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0125 0.0116
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.009 0.0094
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0332 0.1152
Toxoplasma gondii alpha-tubulin I, putative 0.0055 0.0587 0.8571
Schistosoma mansoni tubulin subunit alpha 0.0055 0.0587 0.0662
Onchocerca volvulus 0.0234 0.285 1
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0125 0.0115
Echinococcus granulosus cpg binding protein 0.003 0.0264 0.03
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0065 0.0065
Toxoplasma gondii cyclin 4, putative 0.002 0.014 0.1998
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.0622 0.472
Trichomonas vaginalis cyclin B, putative 0.0112 0.1307 0.4582
Echinococcus multilocularis Tubulin beta 2C chain 0.0062 0.0673 0.0663
Leishmania major alpha tubulin 0.0055 0.0587 0.4373
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0446 0.327
Echinococcus multilocularis tubulin alpha chain 0.0055 0.0587 0.0578
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0024 0.0186 0.0188
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0125 0.0449
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.009 0.0486
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0055 0.0587 0.0662
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0188 0.0647
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0074 0.0358
Loa Loa (eye worm) BEN-1 protein 0.0062 0.0673 0.2598
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.02 0.1346
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0125 0.0135
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0036 0.0105
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0083 0.0066
Leishmania major gamma-tubulin 0.0047 0.0485 0.357
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.009 0.0486
Trichomonas vaginalis tubulin beta chain, putative 0.0055 0.0587 0.2052
Schistosoma mansoni microtubule-associated protein tau 0.0681 0.8493 1
Schistosoma mansoni alpha tubulin 0.0055 0.0587 0.0662
Giardia lamblia Alpha-tubulin 0.0055 0.0587 0.4137
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0252 0.3645
Entamoeba histolytica hypothetical protein 0.0035 0.0335 0.2396
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0125 0.0116
Schistosoma mansoni tubulin subunit beta 0.0062 0.0673 0.0763
Echinococcus multilocularis DNA polymerase zeta catalytic subunit 0.0015 0.008 0.0069
Trichomonas vaginalis tubulin, putative 0.0027 0.0225 0.0776
Trypanosoma brucei beta tubulin 0.0062 0.0673 0.5041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0332 0.1152
Brugia malayi Pre-SET motif family protein 0.0206 0.2489 0.9613
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0083 0.0112
Plasmodium falciparum cyclin 0.0083 0.0939 1
Trichomonas vaginalis cyclins, putative 0.0112 0.1307 0.4582
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0252 0.1406
Entamoeba histolytica hypothetical protein 0.0035 0.0335 0.2396
Giardia lamblia GTOR 0.0044 0.0446 0.2987
Echinococcus granulosus expressed protein 0.0368 0.4541 0.5342
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0125 0.0115
Entamoeba histolytica tubulin family protein 0.0062 0.0673 0.5041
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0152 0.052
Leishmania major beta tubulin 0.0062 0.0673 0.5041
Trypanosoma brucei DNA polymerase delta catalytic subunit, putative 0.0015 0.008 0.0404
Brugia malayi glutathione reductase 0.0047 0.0476 0.1808
Leishmania major hypothetical protein, conserved 0.0025 0.02 0.1346
Trypanosoma cruzi cyclin 6, putative 0.0112 0.1307 1
Toxoplasma gondii hypothetical protein 0.002 0.014 0.1998
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.02 0.1346
Trichomonas vaginalis tubulin beta chain, putative 0.0062 0.0673 0.2352
Plasmodium falciparum tubulin beta chain 0.0062 0.0673 0.6903
Trichomonas vaginalis tubulin, putative 0.0062 0.0673 0.2352
Toxoplasma gondii hypothetical protein 0.0063 0.0685 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0254 0.0981
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.0074 0.0055
Leishmania major DNA polymerase epsilon catalytic subunit, putative 0.0015 0.008 0.0404
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0074 0.0246
Echinococcus granulosus intermediate filament protein 0.0054 0.0568 0.0658
Loa Loa (eye worm) hypothetical protein 0.0024 0.0186 0.0717
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0335 0.0363
Echinococcus multilocularis cyclin G2 0.002 0.014 0.013
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0508 0.1933
Schistosoma mansoni tubulin subunit beta 0.0021 0.0146 0.0141
Echinococcus multilocularis DNA polymerase alpha catalytic subunit 0.0055 0.0587 0.0578
Trypanosoma brucei cyclin 9 0.002 0.014 0.0875
Onchocerca volvulus DNA polymerase homolog 0.0015 0.008 0.0052
Echinococcus granulosus tubulin epsilon chain 0.0047 0.0485 0.0559
Loa Loa (eye worm) alpha-tubulin 0.0055 0.0587 0.2269
Loa Loa (eye worm) BEN-1 protein 0.0062 0.0673 0.2598
Leishmania major beta tubulin 0.0062 0.0673 0.5041
Trypanosoma brucei beta tubulin 0.0062 0.0673 0.5041
Onchocerca volvulus DNA polymerase delta catalytic subunit homolog 0.0015 0.008 0.0052
Echinococcus granulosus DNA polymerase alpha catalytic subunit 0.0055 0.0587 0.068
Trichomonas vaginalis set domain proteins, putative 0.0234 0.2848 1
Trypanosoma brucei DNA polymerase zeta catalytic subunit, putative 0.0015 0.008 0.0404
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.1231 0.8857
Schistosoma mansoni tubulin subunit beta 0.0062 0.0673 0.0763
Loa Loa (eye worm) hypothetical protein 0.0024 0.0186 0.0717
Schistosoma mansoni hypothetical protein 0.0016 0.0083 0.0066
Echinococcus granulosus cyclin y 0.002 0.014 0.0153
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.1242 0.4351
Schistosoma mansoni netrin receptor unc5 0.0014 0.0065 0.0045
Echinococcus multilocularis cyclins 0.0083 0.0939 0.093
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.009 0.0086
Loa Loa (eye worm) cyclin fold protein 1 variant b 0.002 0.014 0.054
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0335 0.0382
Entamoeba histolytica cyclin family protein 0.0083 0.0939 0.7121
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0015 0.008 0.0404
Echinococcus granulosus cyclin 0.002 0.014 0.0153
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0303 0.105
Trichomonas vaginalis cyclins, putative 0.002 0.014 0.0478
Trichomonas vaginalis tubulin epsilon chain, putative 0.0062 0.0673 0.2352
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0676 0.261
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0266 0.0301
Trichomonas vaginalis cyclins, putative 0.0112 0.1307 0.4582
Loa Loa (eye worm) cyclin domain-containing protein 0.002 0.014 0.054
Plasmodium falciparum tubulin delta chain, putative 0.0021 0.0146 0.077
Echinococcus granulosus tar DNA binding protein 0.0062 0.0676 0.0785
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0303 0.105
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0252 0.0872
Brugia malayi Tubulin alpha chain 0.0021 0.0146 0.0531
Echinococcus granulosus tubulin alpha chain 0.0055 0.0587 0.068
Plasmodium falciparum DNA polymerase alpha catalytic subunit A 0.0016 0.0084 0.0056
Trichomonas vaginalis DNA polymerase zeta catalytic subunit, putative 0.0015 0.008 0.0266
Giardia lamblia Cyclin B-like protein 0.002 0.014 0.0491
Trypanosoma brucei alpha tubulin, putative 0.0027 0.0225 0.1537
Echinococcus multilocularis Cyclin L1 0.002 0.014 0.013
Loa Loa (eye worm) tubulin beta chain 0.0062 0.0673 0.2598
Plasmodium falciparum cyclin 1 0.002 0.014 0.0701
Schistosoma mansoni cyclin l 0.002 0.014 0.0134
Echinococcus multilocularis tubulin alpha chain 0.0055 0.0587 0.0578
Mycobacterium ulcerans cell division protein FtsZ 0.0021 0.0146 0.0662
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0125 0.0135
Echinococcus granulosus beta tubulin 0.0062 0.0673 0.0781
Loa Loa (eye worm) CYL-1 protein 0.002 0.014 0.054
Echinococcus multilocularis tubulin alpha 3 chain 0.0055 0.0587 0.0578
Loa Loa (eye worm) hypothetical protein 0.003 0.0266 0.1027
Echinococcus granulosus tubulin subunit beta 0.0062 0.0673 0.0781
Brugia malayi intermediate filament protein 0.0054 0.0568 0.2168
Trichomonas vaginalis conserved hypothetical protein 0.002 0.014 0.0478
Leishmania major DNA polymerase I alpha catalytic subunit, putative 0.0024 0.0192 0.1283
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0074 0.0246
Entamoeba histolytica cyclin family protein 0.0083 0.0939 0.7121
Loa Loa (eye worm) hypothetical protein 0.0112 0.1307 0.5049
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.009 0.0402
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.02 0.1403
Trypanosoma brucei cytochrome P450, putative 0.0023 0.0182 0.1206
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0182 0.1206
Loa Loa (eye worm) hypothetical protein 0.0017 0.0098 0.0379
Plasmodium vivax glutathione reductase, putative 0.0047 0.0476 0.6751
Echinococcus multilocularis Tubulin alpha 1 chain 0.0055 0.0587 0.0578
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0125 0.0116
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0083 0.0285
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0027 0.0225 0.0776
Loa Loa (eye worm) hypothetical protein 0.0019 0.0125 0.0482
Echinococcus granulosus cytochrome P450 2K1 0.0014 0.0068 0.0068
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0125 0.0482
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0221 0.0762
Loa Loa (eye worm) cyclin C 0.002 0.014 0.054
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0446 0.1695
Trichomonas vaginalis tubulin epsilon chain, putative 0.0055 0.0587 0.2052
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0047 0.0485 0.7061
Trichomonas vaginalis conserved hypothetical protein 0.002 0.014 0.0478
Onchocerca volvulus 0.002 0.014 0.0269
Schistosoma mansoni cytochrome P450 0.0014 0.0068 0.0049
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0065 0.0218
Onchocerca volvulus 0.0028 0.0244 0.0642
Schistosoma mansoni g1/s-specific cyclin C 0.002 0.014 0.0134
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0332 0.2377
Leishmania major beta tubulin 0.0062 0.0673 0.5041
Echinococcus multilocularis lamin dm0 0.0054 0.0568 0.0559
Trypanosoma brucei beta tubulin 0.0062 0.0673 0.5041
Leishmania major alpha tubulin 0.0055 0.0587 0.4373
Brugia malayi tubulin alpha-2 chain 0.0055 0.0587 0.2242
Echinococcus granulosus GPCR family 2 0.0016 0.0083 0.0085
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.009 0.0486
Echinococcus multilocularis tubulin alpha chain 0.0055 0.0587 0.0578
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.002 0.014 0.0134
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.009 0.0486
Leishmania major beta tubulin 0.0062 0.0673 0.5041
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0125 0.0135
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0014 0.0068 0.0314
Entamoeba histolytica tubulin alpha chain, putative 0.0055 0.0587 0.4373
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0252 0.0872
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.0622 0.0612
Brugia malayi Cyclin, N-terminal domain containing protein 0.0112 0.1307 0.5032
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0067 0.0047
Echinococcus granulosus tubulin gamma 1 chain 0.0047 0.0485 0.0559
Onchocerca volvulus 0.0027 0.0225 0.0573
Entamoeba histolytica DNA polymerase alpha catalytic subunit, putative 0.0016 0.0084 0.0442
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0035 0.0327 0.1264
Echinococcus granulosus Tubulin beta 2C chain 0.0062 0.0673 0.0781
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0332 0.1152
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0446 0.0496
Trichomonas vaginalis tubulin gamma chain, putative 0.0021 0.0146 0.0499
Schistosoma mansoni laminin gamma-3 chain 0.0024 0.0186 0.0188
Leishmania major beta tubulin 0.0062 0.0673 0.5041
Echinococcus multilocularis G1:S specific cyclin D1 0.002 0.014 0.013
Echinococcus granulosus beta tubulin 0.0062 0.0673 0.0781
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0252 0.0872
Plasmodium falciparum thioredoxin reductase 0.0047 0.0476 0.4607
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0125 0.0482
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0125 0.0116
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0083 0.0072
Schistosoma mansoni hypothetical protein 0.0403 0.4987 0.5859
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.009 0.008
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0676 0.0666
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0939 0.3287
Loa Loa (eye worm) tubulin gamma chain 0.0047 0.0485 0.1872
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0125 0.0449
Schistosoma mansoni cyclin G 0.002 0.014 0.0134
Onchocerca volvulus 0.0112 0.1307 0.4461
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0065 0.0045
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0015 0.008 0.0404
Leishmania major mitotic cyclin, putative 0.002 0.014 0.0875
Echinococcus multilocularis cyclins 0.0083 0.0939 0.093
Echinococcus granulosus cyclin B 0.0112 0.1307 0.1529
Echinococcus granulosus Tubulin alpha 1 chain 0.0055 0.0587 0.068
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0568 0.2195
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0.0074 0.0064
Echinococcus granulosus cyclin k 0.002 0.014 0.0153
Mycobacterium ulcerans 6-phosphofructokinase 0.0107 0.1242 1
Loa Loa (eye worm) hypothetical protein 0.002 0.014 0.054
Echinococcus multilocularis Tubulin beta 2C chain 0.0062 0.0673 0.0663
Trypanosoma brucei tubulin gamma chain 0.0047 0.0485 0.357
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0676 0.0767
Entamoeba histolytica hypothetical protein 0.002 0.014 0.0875
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0508 0.196
Toxoplasma gondii thioredoxin reductase 0.0047 0.0476 0.6927
Leishmania major mitotic cyclin, putative 0.002 0.014 0.0875
Brugia malayi alpha-tubulin 0.0055 0.0587 0.2242
Echinococcus multilocularis tubulin alpha 1C chain 0.0055 0.0587 0.0578
Brugia malayi beta-tubulin, identical 0.0062 0.0673 0.2573
Echinococcus multilocularis neurogenic locus notch protein 0.0024 0.0186 0.0176
Echinococcus granulosus DNA polymerase zeta catalytic subunit 0.0015 0.008 0.0082
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0125 0.0115
Leishmania major beta tubulin 0.0062 0.0673 0.5041
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.009 0.0486
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.009 0.0486
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0083 0.0073
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0083 0.1159
Echinococcus granulosus cyclins 0.0083 0.0939 0.1095
Loa Loa (eye worm) abnormal epIthelia family member 0.0024 0.0186 0.0717
Echinococcus multilocularis slit 2 protein 0.0024 0.0186 0.0176
Echinococcus multilocularis geminin 0.0167 0.1999 0.1991
Schistosoma mansoni tubulin subunit alpha 0.0021 0.0146 0.0141
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0021 0.0146 0.0499
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0125 0.0116
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0676 0.0767
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.009 0.1267
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0152 0.052
Brugia malayi Tubulin gamma chain 0.0047 0.0485 0.1844
Echinococcus multilocularis expressed protein 0.0368 0.4541 0.4536
Entamoeba histolytica DNA polymerase delta catalytic subunit, putative 0.0015 0.008 0.0404
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0446 0.327
Echinococcus granulosus tubulin delta chain 0.0021 0.0146 0.016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0036 0.0113
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0058 0.0622 0.4644
Brugia malayi laminin alpha chain 0.0024 0.0186 0.0685
Entamoeba histolytica cyclin, putative 0.0083 0.0939 0.7121
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0015 0.008 0.0266
Schistosoma mansoni cyclin d 0.002 0.014 0.0134
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.0119 0.0708
Echinococcus granulosus dnaJ subfamily B 0.0403 0.4987 0.5867
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0058 0.0622 0.4218
Giardia lamblia Beta tubulin 0.0062 0.0673 0.4832
Leishmania major alpha tubulin 0.0055 0.0587 0.4373
Loa Loa (eye worm) hypothetical protein 0.0025 0.0203 0.0783
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.009 0.0486
Echinococcus granulosus nuclear factor of activated T cells 5 0.0073 0.0804 0.0936
Onchocerca volvulus 0.0054 0.0568 0.1807
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0125 0.0449
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0083 0.0287
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0303 0.105
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.009 0.0187
Trichomonas vaginalis tubulin gamma chain, putative 0.0062 0.0673 0.2352
Brugia malayi DNA polymerase alpha catalytic subunit 0.0045 0.0455 0.1728
Loa Loa (eye worm) hypothetical protein 0.0049 0.0503 0.1941
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0476 0.0548
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0014 0.0068 0.0314
Plasmodium vivax tubulin alpha chain, putative 0.0055 0.0587 0.8594
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.1242 0.9486
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0446 0.327
Plasmodium falciparum cyclin dependent kinase binding protein, putative 0.002 0.014 0.0701
Trichomonas vaginalis tubulin gamma chain, putative 0.0047 0.0485 0.169
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.1242 0.4795
Echinococcus granulosus oligomeric golgi complex subunit 3 0.002 0.014 0.0153
Schistosoma mansoni cpg binding protein 0.003 0.0264 0.0281
Schistosoma mansoni hypothetical protein 0.0051 0.0531 0.0595
Trichomonas vaginalis cyclin D, putative 0.002 0.014 0.0478
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0083 0.0085
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0446 0.0514
Echinococcus granulosus alpha tubulin 0.0055 0.0587 0.068
Brugia malayi Cytochrome P450 family protein 0.0054 0.0565 0.2156
Echinococcus granulosus bloom syndrome protein 0.0021 0.0152 0.0167
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0035 0.0327 0.1137
Giardia lamblia Hypothetical protein 0.0083 0.0939 0.7
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.1242 0.9486
Schistosoma mansoni hypothetical protein 0.0014 0.0068 0.0049
Echinococcus multilocularis Tubulin alpha 1 chain 0.0055 0.0587 0.0578
Echinococcus granulosus cyclin B3 1 0.0083 0.0939 0.1095
Echinococcus multilocularis cyclins 0.0083 0.0939 0.093
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.1242 0.1435
Loa Loa (eye worm) cytochrome P450 family protein 0.0054 0.0565 0.2183
Echinococcus granulosus tubulin alpha 3 chain 0.0055 0.0587 0.068
Echinococcus granulosus tumor protein p63 0.0333 0.41 0.4822
Trypanosoma brucei DNA polymerase alpha catalytic subunit 0.0024 0.0192 0.1283
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0252 0.0872
Giardia lamblia Cyclin A 0.0083 0.0939 0.7
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.1231 0.8857
Schistosoma mansoni cell polarity protein 0.0024 0.0186 0.0188
Echinococcus multilocularis pikachurin 0.0024 0.0186 0.0176
Echinococcus granulosus cyclins 0.0083 0.0939 0.1095
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0083 0.0429
Schistosoma mansoni tubulin subunit epsilon 0.0047 0.0485 0.0541
Loa Loa (eye worm) tubulin beta-1 chain 0.0062 0.0673 0.2598
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0568 0.2195
Brugia malayi 6-phosphofructokinase 0.0107 0.1242 0.4777
Echinococcus granulosus 6 phosphofructokinase 0.0107 0.1242 0.1451
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0083 0.0429
Loa Loa (eye worm) hypothetical protein 0.0112 0.1307 0.5049
Plasmodium falciparum alpha tubulin 1 0.0055 0.0587 0.591
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0335 0.0325
Echinococcus multilocularis tubulin alpha chain 0.0055 0.0587 0.0578
Loa Loa (eye worm) hypothetical protein 0.002 0.014 0.054
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.009 0.0402
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0152 0.0142
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0015 0.0074 0.0358
Loa Loa (eye worm) cyclin domain-containing protein 0.002 0.014 0.054
Echinococcus granulosus cyclin y 0.002 0.014 0.0153
Brugia malayi hypothetical protein 0.0019 0.0125 0.0449
Toxoplasma gondii DNA polymerase family B protein 0.0015 0.008 0.1112
Loa Loa (eye worm) tubulin beta-4 chain 0.0062 0.0673 0.2598
Echinococcus granulosus tubulin beta 4A class IVa 0.0062 0.0673 0.0781
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.009 0.0486
Trichomonas vaginalis cyclin A, putative 0.002 0.014 0.0478
Plasmodium vivax hypothetical protein, conserved 0.002 0.014 0.1222
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0125 0.0116
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0125 0.0482
Loa Loa (eye worm) hypothetical protein 0.0024 0.0186 0.0717
Trichomonas vaginalis cyclins, putative 0.0049 0.0508 0.1773
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0311 0.117
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.009 0.0486
Loa Loa (eye worm) phosphofructokinase 0.0107 0.1242 0.4795
Trichomonas vaginalis cyclin A, putative 0.0112 0.1307 0.4582
Echinococcus granulosus Tubulin beta 2C chain 0.0062 0.0673 0.0781
Leishmania major DNA polymerase delta catalytic subunit, putative 0.0015 0.008 0.0404
Schistosoma mansoni cyclins 0.0083 0.0939 0.1077
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0252 0.3069
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.02 0.2214
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0074 0.0246
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0024 0.0192 0.0662
Leishmania major trypanothione reductase 0.0047 0.0476 0.3499
Loa Loa (eye worm) hypothetical protein 0.0014 0.0067 0.0257
Trichomonas vaginalis cyclins, putative 0.0083 0.0939 0.3287
Loa Loa (eye worm) hypothetical protein 0.0054 0.0568 0.2195
Onchocerca volvulus Protein CNPPD1 homolog 0.002 0.014 0.0269
Schistosoma mansoni hypothetical protein 0.0035 0.0335 0.0363
Plasmodium vivax tubulin gamma chain, putative 0.0047 0.0485 0.6901
Echinococcus granulosus tubulin alpha chain 0.0055 0.0587 0.068
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0073 0.0804 0.0795
Echinococcus granulosus Tubulin beta 2C chain 0.0062 0.0673 0.0781
Trypanosoma cruzi tubulin gamma chain 0.0047 0.0485 0.357
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0221 0.0762
Trichomonas vaginalis cyclin B, putative 0.0112 0.1307 0.4582
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0021 0.0146 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.002 0.014 0.0508
Onchocerca volvulus DNA polymerase alpha catalytic subunit homolog 0.0076 0.085 0.2819
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0058 0.0622 0.0703
Loa Loa (eye worm) cyclin domain-containing protein 0.002 0.014 0.054
Echinococcus multilocularis lamin 0.0054 0.0568 0.0559
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0266 0.0282
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0083 0.0282
Echinococcus multilocularis cyclin k 0.002 0.014 0.013
Schistosoma mansoni hypothetical protein 0.0167 0.1999 0.233
Echinococcus granulosus cyclins 0.0083 0.0939 0.1095
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0659 0.0747
Trichomonas vaginalis conserved hypothetical protein 0.002 0.014 0.0478
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0074 0.0358
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0508 0.1933
Brugia malayi Cyclin, N-terminal domain containing protein 0.0214 0.2589 1
Brugia malayi hypothetical protein 0.0149 0.1771 0.6827
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0125 0.0449
Echinococcus granulosus Tubulin beta 2C chain 0.0062 0.0673 0.0781
Leishmania major beta tubulin 0.0062 0.0673 0.5041
Echinococcus multilocularis cyclins 0.0083 0.0939 0.093
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.1242 0.4351
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0125 0.0116
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0118 0.1381 1
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0096 0.0082
Loa Loa (eye worm) tubulin alpha 2 0.0035 0.0327 0.1264
Echinococcus granulosus pikachurin 0.0024 0.0186 0.0207
Trichomonas vaginalis tubulin alpha chain, putative 0.0027 0.0225 0.0776
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0476 0.1837
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0476 0.0466
Trypanosoma brucei alpha tubulin 0.0055 0.0587 0.4373
Trypanosoma brucei tubulin delta chain 0.0021 0.0146 0.0921
Schistosoma mansoni DNA polymerase epsilon catalytic subunit 0.0015 0.008 0.0062
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0083 0.0319
Echinococcus multilocularis tubulin delta chain 0.0021 0.0146 0.0136
Echinococcus multilocularis cyclins 0.0083 0.0939 0.093
Leishmania major cytochrome p450-like protein 0.0014 0.0068 0.0314
Loa Loa (eye worm) tubulin alpha chain 0.0055 0.0587 0.2269
Plasmodium falciparum alpha tubulin 2 0.0055 0.0587 0.591
Plasmodium falciparum tubulin epsilon chain, putative 0.0047 0.0485 0.4714
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0083 0.0429
Echinococcus multilocularis 6 phosphofructokinase 0.0107 0.1242 0.1233
Echinococcus multilocularis cyclin G2 0.002 0.014 0.013
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.02 0.2883
Leishmania major alpha tubulin 0.0055 0.0587 0.4373
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0107 0.1242 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.0622 0.472
Loa Loa (eye worm) histone methyltransferase 0.001 0.001 0.004
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.1242 0.4795
Schistosoma mansoni tubulin subunit beta 0.0062 0.0673 0.0763
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0446 0.1555
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.1242 0.1435
Echinococcus granulosus tubulin alpha 0.0047 0.0485 0.0559
Plasmodium vivax tubulin alpha chain, putative 0.0055 0.0587 0.8594
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0125 0.0425
Loa Loa (eye worm) cyclin domain-containing protein 0.002 0.014 0.054
Echinococcus granulosus dna polymerase epsilon catalytic subunit a 0.0015 0.008 0.0082
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0125 0.0115
Echinococcus granulosus Tubulin beta 2C chain 0.0062 0.0673 0.0781
Entamoeba histolytica hypothetical protein 0.0019 0.0125 0.0757
Schistosoma mansoni cyclin G2 0.002 0.014 0.0134
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0083 0.0073
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0125 0.0135
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.009 0.0486
Trichomonas vaginalis conserved hypothetical protein 0.002 0.014 0.0478
Trypanosoma cruzi mitotic cyclin, putative 0.002 0.014 0.0875
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0252 0.2006
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0055 0.0587 0.2052
Leishmania major beta tubulin 0.0062 0.0673 0.5041
Brugia malayi Death domain containing protein 0.0014 0.0065 0.0218
Trichomonas vaginalis tubulin alpha chain, putative 0.0027 0.0225 0.0776
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0676 0.261
Plasmodium vivax SET domain protein, putative 0.003 0.0266 0.3298
Echinococcus multilocularis tubulin subunit beta 0.0062 0.0673 0.0663
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0014 0.0068 0.0314
Schistosoma mansoni cpg binding protein 0.0028 0.0244 0.0257
Trypanosoma brucei epsilon tubulin 0.0047 0.0485 0.357
Trichomonas vaginalis DNA polymerase delta catalytic subunit, putative 0.0015 0.008 0.0266
Echinococcus multilocularis Tubulin beta 2C chain 0.0062 0.0673 0.0663
Leishmania major beta tubulin 0.0062 0.0673 0.5041
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0083 0.0073
Echinococcus granulosus cdk5 and abl1 enzyme substrate 1 0.002 0.014 0.0153
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0217 0.0751
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0188 0.0649
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0083 0.0429
Trichomonas vaginalis tubulin gamma chain, putative 0.0047 0.0485 0.169
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0125 0.0425
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0252 0.2006
Brugia malayi Cyclin, N-terminal domain containing protein 0.002 0.014 0.0508
Trypanosoma brucei cyclin dependent kinase-binding protein, putative 0.002 0.014 0.0875
Loa Loa (eye worm) hypothetical protein 0.0019 0.0125 0.0482
Brugia malayi tubulin alpha chain - mouse 0.0055 0.0587 0.2242
Echinococcus multilocularis musashi 0.0054 0.0568 0.0559
Schistosoma mansoni hypothetical protein 0.0167 0.1999 0.233
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0217 0.0751
Onchocerca volvulus Cyclin L homolog 0.002 0.014 0.0269
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0125 0.0449
Trichomonas vaginalis tubulin beta chain, putative 0.0055 0.0587 0.2052
Brugia malayi hypothetical protein 0.0035 0.0335 0.1262
Schistosoma mansoni tubulin subunit beta 0.0062 0.0673 0.0763
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0021 0.0146 0.2084
Entamoeba histolytica hypothetical protein 0.0019 0.0125 0.0757
Echinococcus multilocularis tubulin epsilon chain 0.0047 0.0485 0.0475
Schistosoma mansoni alpha tubulin 0.0055 0.0587 0.0662
Trichomonas vaginalis tubulin beta chain, putative 0.0055 0.0587 0.2052
Brugia malayi Protein kinase domain containing protein 0.0014 0.0065 0.0218
Leishmania major beta tubulin 0.0062 0.0673 0.5041
Schistosoma mansoni hypothetical protein 0.0016 0.0083 0.0066
Echinococcus multilocularis cpg binding protein 0.003 0.0264 0.0254
Brugia malayi Tubulin alpha chain 0.0055 0.0587 0.2242
Loa Loa (eye worm) hypothetical protein 0.0019 0.0125 0.0482
Schistosoma mansoni DNA polymerase delta catalytic subunit 0.0015 0.008 0.0062
Loa Loa (eye worm) hypothetical protein 0.0025 0.02 0.0773
Leishmania major cyclin 9, putative 0.002 0.014 0.0875
Trypanosoma cruzi zeta tubulin, putative 0.0021 0.0146 0.0921
Schistosoma mansoni hypothetical protein 0.002 0.014 0.0134
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0152 0.0554
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0083 0.1159
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0251 0.094
Leishmania major cytochrome p450-like protein 0.0014 0.0068 0.0314
Entamoeba histolytica cyclin, domain containing protein 0.002 0.014 0.0875
Trypanosoma cruzi mitotic cyclin, putative 0.002 0.014 0.0875
Loa Loa (eye worm) tubulin beta-2A chain 0.0062 0.0673 0.2598
Brugia malayi RNA binding protein 0.0062 0.0676 0.2585
Brugia malayi Tubulin beta chain 0.0021 0.0146 0.0531
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0252 0.3069
Toxoplasma gondii beta tubulin 0.0062 0.0673 0.9824
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0107 0.1242 0.8936
Entamoeba histolytica tubulin family protein 0.0062 0.0673 0.5041
Brugia malayi EGF-like domain containing protein 0.0024 0.0186 0.0685
Plasmodium vivax cyclin homologue, putative 0.002 0.014 0.1222
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0676 0.0767
Mycobacterium tuberculosis Probable oxidoreductase 0.0118 0.1381 1
Echinococcus multilocularis tumor protein p63 0.0333 0.41 0.4094
Leishmania major beta tubulin 0.0062 0.0673 0.5041
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0146 0.0499
Leishmania major alpha tubulin 0.0055 0.0587 0.4373
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0083 0.0086
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0074 0.0285
Brugia malayi Cyclin, N-terminal domain containing protein 0.0112 0.1307 0.5032
Loa Loa (eye worm) hypothetical protein 0.0019 0.0125 0.0482
Loa Loa (eye worm) hypothetical protein 0.0026 0.0215 0.0831
Loa Loa (eye worm) hypothetical protein 0.0055 0.0587 0.2269
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.009 0.0486
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.009 0.0187
Echinococcus multilocularis 0.0014 0.0068 0.0058
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0015 0.0074 0.0358
Trichomonas vaginalis cyclin B3, putative 0.0083 0.0939 0.3287
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.009 0.0303
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0027 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0446 0.1555
Echinococcus granulosus cyclin t1 0.002 0.014 0.0153
Leishmania major beta tubulin 0.0062 0.0673 0.5041
Trypanosoma cruzi zeta tubulin, putative 0.0021 0.0146 0.0921
Schistosoma mansoni slit 0.0024 0.0186 0.0188
Leishmania major epsilon tubulin, putative 0.0047 0.0485 0.357
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0125 0.0115
Plasmodium falciparum tubulin gamma chain 0.0047 0.0485 0.4714
Brugia malayi hypothetical protein 0.0016 0.0089 0.0309
Leishmania major alpha tubulin 0.0055 0.0587 0.4373
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0676 0.0767
Echinococcus multilocularis DNA polymerase delta catalytic subunit 0.0015 0.008 0.0069
Giardia lamblia Delta tubulin 0.0021 0.0146 0.0539
Echinococcus granulosus cyclin G2 0.002 0.014 0.0153
Trichomonas vaginalis cyclins, putative 0.0112 0.1307 0.4582
Echinococcus granulosus neurogenic locus notch protein 0.0024 0.0186 0.0207
Schistosoma mansoni tubulin subunit beta 0.0062 0.0673 0.0763
Brugia malayi cytochrome P450 0.0014 0.0068 0.023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0303 0.105
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0266 0.0282
Plasmodium vivax DNA polymerase alpha, putative 0.0045 0.0455 0.641

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) Antagonist activity at Vibrio fischeri ES114 LuxR receptor assessed as inhibition of OHHL-induced response by luciferase reporter gene assay ChEMBL. 18760602
IC50 (functional) Antagonist activity at Agrobacterium tumefaciens WCF47 TraR receptor assessed as inhibition of OOHL-induced response by beta-galctosidase reporter gene assay ChEMBL. 18760602
IC50 (functional) 0 Antagonist activity at Pseudomonas aeruginosa QscR expressed in Escherichia coli assessed as inhibition of dodecanoyl homoserine lactone induced production of beta-galactosidase ChEMBL. 18083553
Inhibition (binding) = 50 % Inhibition of Pseudomonas aerugenosa LasR ChEMBL. 18083553
Inhibition (binding) = 50 % Inhibition of Pseudomonas aerugenosa LasR ChEMBL. 18083553
Inhibition (functional) = 70 % Antagonist activity at Pseudomonas aeruginosa QscR expressed in Escherichia coli assessed as inhibition of dodecanoyl homoserine lactone induced production of beta-galactosidase at 5 uM ChEMBL. 18083553
Inhibition (functional) = 70 % Antagonist activity at Pseudomonas aeruginosa QscR expressed in Escherichia coli assessed as inhibition of dodecanoyl homoserine lactone induced production of beta-galactosidase at 5 uM ChEMBL. 18083553

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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