Detailed information for compound 565944

Basic information

Technical information
  • TDR Targets ID: 565944
  • Name: 3-nitropropanoic acid
  • MW: 119.076 | Formula: C3H5NO4
  • H donors: 1 H acceptors: 4 LogP: -0.48 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)CCC(=O)O
  • InChi: 1S/C3H5NO4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)
  • InChiKey: WBLZUCOIBUDNBV-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 3-nitropropionic acid
  • 504-88-1
  • NCGC00015744-01
  • SPECTRUM1504206
  • KBio1_001732
  • AIDS-059758
  • KBio3_001905
  • NCGC00094169-02
  • NCGC00094169-03
  • BSPBio_002685
  • .beta.-Nitropropionic acid
  • BNP
  • Bovinocidin
  • BRN 1759889
  • CCRIS 454
  • NITROPROPIONIC ACID, BETA
  • NSC64266
  • Propanoic acid, 3-nitro-
  • Propionic acid, 3-nitro-
  • 3NP
  • 3-NPA
  • 504-88-1 (FREE ACID)
  • Lopac0_000838
  • AIDS059758
  • C05669
  • beta-Nitropropanoate
  • beta-Nitropropanoic acid
  • beta-Nitropropionic acid
  • DivK1c_006788
  • SDCCGMLS-0066769.P001
  • SPBio_000951
  • KBioGR_001598
  • SpecPlus_000692
  • NCI-C03076
  • MLS001066410
  • SMR000471863
  • EU-0100838
  • Spectrum3_000993
  • Spectrum_001674
  • 4-02-00-00771 (Beilstein Handbook Reference)
  • Spectrum2_000876
  • Hiptagenic acid
  • 73808_FLUKA
  • KBioSS_002154
  • 3-Nitropropanoate
  • C02516
  • N5636_SIGMA
  • EINECS 208-003-0
  • CHEBI:16348
  • Spectrum4_001119
  • HSDB 4147
  • Lopac-N-5636
  • NSC 64266
  • Spectrum5_001895
  • Propanoic acid, 3-nitro- (9CI)
  • KBio2_002154
  • KBio2_004722
  • KBio2_007290
  • WLN: WN2VQ

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens Bloom syndrome, RecQ helicase-like Starlite/ChEMBL No references
Mycobacterium tuberculosis Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) Curated by TDR Targets References
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Rattus norvegicus Muscarinic acetylcholine receptor M1 Starlite/ChEMBL No references
Mycobacterium tuberculosis Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) Curated by TDR Targets References
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Homo sapiens hemoglobin, beta Starlite/ChEMBL No references
Homo sapiens nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Starlite/ChEMBL No references
Candida albicans isocitrate lyase capable of functionally substituting for S. cerevisiae ICL1 (YER065C) Starlite/ChEMBL References
Magnaporthe oryzae (strain 70-15 / FGSC 8958) (Rice blast fungus)(Pyricularia oryzae) Isocitrate lyase Starlite/ChEMBL References
Mycobacterium tuberculosis Isocitrate lyase Icl (isocitrase) (isocitratase) Curated by TDR Targets References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium ulcerans isocitrate lyase Icl Get druggable targets OG5_129572 All targets in OG5_129572
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans isocitrate lyase capable of functionally substituting for S. cerevisiae ICL1 (YER065C) Get druggable targets OG5_129572 All targets in OG5_129572
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium leprae PROBABLE ISOCITRATE LYASE AceA (ISOCITRASE) (ISOCITRATASE) (ICL) Get druggable targets OG5_129572 All targets in OG5_129572
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium tuberculosis Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) Get druggable targets OG5_129572 All targets in OG5_129572
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans isocitrate lyase capable of functionally substituting for S. cerevisiae ICL1 (YER065C) Get druggable targets OG5_129572 All targets in OG5_129572
Mycobacterium ulcerans isocitrate lyase AceAb Get druggable targets OG5_129572 All targets in OG5_129572
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium tuberculosis Isocitrate lyase Icl (isocitrase) (isocitratase) Get druggable targets OG5_129572 All targets in OG5_129572
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium tuberculosis Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) Get druggable targets OG5_129572 All targets in OG5_129572
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Echinococcus multilocularis serotonin receptor Muscarinic acetylcholine receptor M1   460 aa 432 aa 26.6 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Muscarinic acetylcholine receptor M1   460 aa 462 aa 23.4 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Loa Loa (eye worm) hypothetical protein Muscarinic acetylcholine receptor M1   460 aa 425 aa 22.1 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Plasmodium falciparum GMP synthase [glutamine-hydrolyzing] hemoglobin, beta 147 aa 122 aa 20.5 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Mycobacterium leprae Isocitrate lyase Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) 367 aa 295 aa 87.1 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Echinococcus granulosus biogenic amine 5HT receptor Muscarinic acetylcholine receptor M1   460 aa 432 aa 26.6 %
Schistosoma mansoni amine GPCR Muscarinic acetylcholine receptor M1   460 aa 463 aa 27.0 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Mycobacterium leprae Isocitrate lyase Isocitrate lyase   547 aa 536 aa 35.4 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni nocturnin 0.0012 0.0014 0.0093
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0221 0.0414
Brugia malayi RNA binding protein 0.0076 0.0221 0.2597
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0058 0.0162 0.1531
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0037 0.0236
Brugia malayi latrophilin 2 splice variant baaae 0.0177 0.0544 0.6447
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0012 0.0014 0.0892
Loa Loa (eye worm) hypothetical protein 0.0074 0.0215 0.2049
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.016 0.015
Loa Loa (eye worm) glutathione reductase 0.0057 0.016 0.1513
Leishmania major hypothetical protein, conserved 0.0012 0.0014 0.0048
Mycobacterium tuberculosis Probable exported protein 0.0012 0.0014 0.0005
Brugia malayi Globin family protein 0.001 0.001 0.0066
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0236
Echinococcus granulosus nuclear factor of activated T cells 5 0.0089 0.0261 0.1657
Echinococcus granulosus tar DNA binding protein 0.0076 0.0221 0.14
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0092 0.0845
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.002 0.0055
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0014 0.0122
Treponema pallidum exodeoxyribonuclease (exoA) 0.0058 0.0162 1
Schistosoma mansoni hypothetical protein 0.0037 0.0095 0.0612
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0092 0.1083
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0215 0.0205
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0021 0.0243
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.002 0.004 0.2485
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0021 0.0243
Leishmania major inositol/phosphatidylinositol phosphatase, putative 0.0012 0.0014 0.0048
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.002 0.0227
Brugia malayi RNA, U transporter 1 0.0088 0.0258 0.3029
Onchocerca volvulus 0.0033 0.0081 0.0934
Brugia malayi Globin family protein 0.001 0.001 0.0066
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0054
Echinococcus multilocularis bloom syndrome protein 0.0026 0.0059 0.0105
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0162 1
Brugia malayi Death domain containing protein 0.0017 0.0033 0.0338
Brugia malayi Pre-SET motif family protein 0.0033 0.0081 0.0919
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.0574 0.6828
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.013 0.0393 0.0183
Schistosoma mansoni carbon catabolite repressor protein 0.0012 0.0014 0.0093
Schistosoma mansoni ran 0.0023 0.005 0.032
Trypanosoma brucei unspecified product 0.0013 0.0019 0.0043
Brugia malayi Importin beta-1 subunit 0.0031 0.0076 0.0854
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0215 0.0205
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0014 0.0101
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0215 0.0205
Echinococcus multilocularis traf and tnf receptor associated protein 0.0012 0.0014 0.0019
Leishmania major DNA polymerase eta, putative 0.0019 0.0037 0.0283
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0014 0.0122
Loa Loa (eye worm) hypothetical protein 0.0015 0.0025 0.0206
Entamoeba histolytica hypothetical protein 0.0037 0.0095 0.5871
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0021 0.0243
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0021 0.0243
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0092 0.1045
Loa Loa (eye worm) hypothetical protein 0.0015 0.0025 0.0206
Brugia malayi Muscleblind-like protein 0.0145 0.0441 0.5219
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0215 0.0205
Echinococcus granulosus snurportin 1 0.033 0.103 0.6617
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.004 0.0315
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0021 0.0243
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0215 0.138
Echinococcus multilocularis Ankyrin 0.0018 0.0033 0.0055
Brugia malayi CXXC zinc finger family protein 0.0061 0.0171 0.1996
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0011 0.0081
Entamoeba histolytica hypothetical protein 0.0037 0.0095 0.5871
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.005 0.0365
Brugia malayi glutathione reductase 0.0057 0.016 0.1856
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0092 0.5653
Brugia malayi hypothetical protein 0.0128 0.0387 0.4573
Onchocerca volvulus Huntingtin homolog 0.0128 0.0387 0.4934
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0215 0.2514
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0017 0.0033 0.0914
Trypanosoma brucei glycosyl hydrolase-like protein 0.0013 0.002 0.0055
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0162 0.1923
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0014 0.0101
Trypanosoma brucei unspecified product 0.0019 0.0037 0.0236
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.004 0.0268
Echinococcus granulosus neutral sphingomyelinase 0.0012 0.0014 0.0066
Leishmania major importin beta-1 subunit, putative 0.0025 0.0057 0.0488
Schistosoma mansoni cpg binding protein 0.0064 0.0182 0.1172
Loa Loa (eye worm) CXXC zinc finger family protein 0.0061 0.0171 0.1627
Echinococcus granulosus dna polymerase kappa 0.0019 0.0037 0.0213
Brugia malayi hypothetical protein 0.0017 0.0032 0.0325
Trypanosoma brucei unspecified product 0.0013 0.0019 0.0043
Schistosoma mansoni hypothetical protein 0.033 0.103 0.6626
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.002 0.004 0.0031
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.002 0.004 0.0431
Schistosoma mansoni lamin 0.0033 0.0081 0.0522
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.002 0.0227
Loa Loa (eye worm) hypothetical protein 0.0145 0.0441 0.4254
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0058 0.0162 0.0153
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0058 0.0162 0.1018
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0011 0.0011 0.0044
Mycobacterium leprae Isocitrate lyase 0.1471 0.4675 0.4559
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.004 0.0268
Onchocerca volvulus 0.0012 0.0014 0.0061
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0057 0.0672
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.0393 0.0384
Loa Loa (eye worm) hypothetical protein 0.0051 0.0141 0.1335
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0012 0.0014 0.0093
Echinococcus multilocularis deoxyribonuclease 1 2 0.0012 0.0014 0.0019
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0037 0.0028
Echinococcus multilocularis neutral sphingomyelinase 0.0012 0.0014 0.0019
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0081 0.0146
Loa Loa (eye worm) hypothetical protein 0.0074 0.0215 0.2049
Schistosoma mansoni DNA helicase recq1 0.0011 0.0011 0.0071
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0011 0.0011 0.0683
Echinococcus granulosus GPCR family 2 0.0082 0.0239 0.1515
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0011 0.0011 0.0066
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0041 0.0236
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.0544 0.6465
Brugia malayi Glycosyl hydrolases family 31 protein 0.0162 0.0494 0.585
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0058 0.0162 0.0301
Echinococcus granulosus bloom syndrome protein 0.0026 0.0059 0.0355
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0021 0.0243
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0215 0.2546
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0054
Toxoplasma gondii histone lysine methyltransferase SET1 0.0116 0.0349 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0221 0.1424
Leishmania major DNA polymerase kappa, putative 0.0019 0.0037 0.0283
Echinococcus granulosus synaptojanin 1 0.0012 0.0014 0.0066
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0215 0.2546
Echinococcus granulosus lysosomal alpha glucosidase 0.0162 0.0494 0.3155
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0021 0.0243
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0012 0.0014 0.0164
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0037 0.0236
Loa Loa (eye worm) hypothetical protein 0.0128 0.0387 0.3727
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0014 0.0101
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0021 0.0068
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0014 0.0122
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0019 0.0043
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0029 0.0159
Trichomonas vaginalis Phospholipase C precursor, putative 0.0012 0.0014 0.0164
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.016 0.1503
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.004 0.0268
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0061 0.0486
Leishmania major inositol phosphosphingolipid phospholipase C-Like 0.0012 0.0014 0.0048
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0037 0.0236
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.0393 0.0384
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0081 0.0749
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0081 0.0522
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0259 0.0806 0.781
Schistosoma mansoni hypothetical protein 0.0177 0.0544 0.3495
Toxoplasma gondii hypothetical protein 0.0051 0.0139 0.3785
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0073 0.0445
Schistosoma mansoni DNA helicase recq5 0.0011 0.0011 0.0071
Echinococcus multilocularis musashi 0.0033 0.0081 0.0146
Mycobacterium tuberculosis Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) 0.3137 1 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0058 0.0162 1
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.0841 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0162 0.0494 0.4768
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0021 0.0243
Onchocerca volvulus 0.0074 0.0215 0.268
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.002 0.0227
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0015 0.0068
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.044 0.023
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0475 0.1494 0.1486
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.005 0.0543
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0037 0.024
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0015 0.0024 0.023
Trichomonas vaginalis mercuric reductase, putative 0.002 0.004 0.0472
Loa Loa (eye worm) hypothetical protein 0.0128 0.0387 0.3727
Brugia malayi exodeoxyribonuclease III family protein 0.0058 0.0162 0.1888
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0027 0.0148
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0029 0.0159
Brugia malayi Protein kinase domain containing protein 0.0017 0.0033 0.0338
Loa Loa (eye worm) hypothetical protein 0.0019 0.0037 0.0321
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.005 0.0087
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0017 0.0033 0.0275
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0215 0.138
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.002 0.004 0.0259
Leishmania major GTP-binding protein, putative 0.0023 0.005 0.0412
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0012 0.0014 0.0099
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.1555 0.2954
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0236
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0012 0.0014 0.0892
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0236
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.002 0.0227
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0012 0.0014 0.0164
Loa Loa (eye worm) hypothetical protein 0.0031 0.0076 0.0696
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.002 0.004 0.0268
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.004 0.0428
Leishmania major trypanothione reductase 0.0057 0.016 0.1544
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0099
Brugia malayi intermediate filament protein 0.0033 0.0081 0.0919
Mycobacterium ulcerans lipase LipD 0.0074 0.0215 0.0205
Brugia malayi Hypothetical 22.2 kDa protein C28F5.2 in chromosome II, putative 0.001 0.001 0.0066
Echinococcus multilocularis netrin receptor unc 5 0.0017 0.0033 0.0054
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.033 0.103 1
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0014 0.0099
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0092 0.5653
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0162 0.1923
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0027 0.0044
Entamoeba histolytica inositol polyphosphate 5-phosphatase, putative 0.0012 0.0014 0.0892
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0215 0.0205
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0099
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0012 0.0014 0.0066
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0058 0.0162 1
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0011 0.0011 0.0044
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0082 0.0239 0.0448
Schistosoma mansoni smad 0.0009 0.0004 0.0028
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0041 0.007
Loa Loa (eye worm) hypothetical protein 0.0026 0.0061 0.0556
Schistosoma mansoni cpg binding protein 0.0064 0.0182 0.1172
Leishmania major hypothetical protein, conserved 0.0074 0.0215 0.2111
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.005 0.0365
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0092 0.1083
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0061 0.0486
Schistosoma mansoni cript-related 0.0012 0.0014 0.0093
Leishmania major hypothetical protein, conserved 0.0012 0.0014 0.0048
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.002 0.004 0.0232
Onchocerca volvulus 0.0249 0.0774 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0137 0.0415 0.0782
Loa Loa (eye worm) globin family protein 0.001 0.001 0.0054
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0215 0.1356
Loa Loa (eye worm) hypothetical protein 0.0013 0.002 0.0151
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0092 0.08
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.0841 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0092 0.1083
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0081 0.0522
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0215 0.0205
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0014 0.0099
Echinococcus granulosus netrin receptor unc 5 0.0017 0.0033 0.0182
Loa Loa (eye worm) hypothetical protein 0.0145 0.0441 0.4254
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0017 0.0033 0.0182
Mycobacterium ulcerans hypothetical protein 0.0074 0.0215 0.0205
Schistosoma mansoni intermediate filament proteins 0.0033 0.0081 0.0522
Mycobacterium ulcerans hypothetical protein 0.0165 0.0505 0.0496
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0033 0.0341
Leishmania major hypothetical protein, conserved 0.0026 0.0061 0.0532
Onchocerca volvulus Glucosylceramidase homolog 0.0177 0.0544 0.6988
Loa Loa (eye worm) hypothetical protein 0.0074 0.0215 0.2049
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0015 0.002
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0032 0.0623
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0037 0.0028
Trypanosoma brucei glucosidase, putative 0.0036 0.0092 0.08
Giardia lamblia NADH oxidase lateral transfer candidate 0.002 0.004 0.1934
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.044 0.043
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.016 0.1513
Echinococcus multilocularis lamin dm0 0.0033 0.0081 0.0146
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0054
Loa Loa (eye worm) hypothetical protein 0.0017 0.0033 0.0275
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0012 0.0014 0.0066
Onchocerca volvulus 0.0074 0.0215 0.268
Loa Loa (eye worm) hypothetical protein 0.0033 0.0081 0.0749
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0021 0.0243
Schistosoma mansoni smad1 5 8 and 0.0009 0.0004 0.0028
Schistosoma mansoni DNA polymerase eta 0.0019 0.0037 0.024
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0221 0.1424
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0259 0.0806 0.9582
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.0544 0.6465
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0137 0.0415 0.2646
Loa Loa (eye worm) MH2 domain-containing protein 0.0125 0.0376 0.3626
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0014 0.0122
Brugia malayi Calcitonin receptor-like protein seb-1 0.0259 0.0806 0.9582
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0141 0.0908
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0082 0.0239 0.0448
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0221 0.2597
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0137 0.0415 0.0782
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0021 0.0243
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0076 0.0635
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0095 0.0612
Schistosoma mansoni lamin 0.0033 0.0081 0.0522
Schistosoma mansoni importin beta-1 0.0031 0.0076 0.0487
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0037 0.0028
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0037 0.024
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0057 0.0672
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0029 0.0186
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.0544 0.6465
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0092 0.1083
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0014 0.0099
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0013 0.002 0.0131
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0076 0.0136
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.004 0.0268
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0012 0.0014 0.0164
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0092 0.0852
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0037 0.0063
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0014 0.0099
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0037 0.0236
Loa Loa (eye worm) hypothetical protein 0.0021 0.0043 0.0375
Onchocerca volvulus Netrin receptor homolog 0.0017 0.0033 0.0298
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0092 0.1083
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0037 0.0236
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0021 0.0243
Brugia malayi hypothetical protein 0.0037 0.0095 0.1087
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0215 0.0205
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0058 0.0162 0.1531
Entamoeba histolytica hypothetical protein 0.0025 0.0057 0.352
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0037 0.0236
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0029 0.0047
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0058 0.0162 0.1539
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0021 0.0068
Mycobacterium tuberculosis Conserved protein 0.0074 0.0215 0.0205
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0215 0.2546
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0236
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.0841 1
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0012 0.0014 0.0164
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.005 0.0443
Giardia lamblia hypothetical protein 0.0012 0.0014 0.0225
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0012 0.0014 0.0892
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.005 0.1145
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0215 0.2049
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0236
Loa Loa (eye worm) hypothetical protein 0.0082 0.0239 0.229
Echinococcus multilocularis lamin 0.0033 0.0081 0.0146
Schistosoma mansoni ap endonuclease 0.0058 0.0162 0.1043
Entamoeba histolytica hypothetical protein 0.0037 0.0095 0.5871
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.005 0.1761
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0037 0.0394
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0058 0.0162 1
Schistosoma mansoni smad1 5 8 and 0.0009 0.0004 0.0028
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0061 0.3784
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0014 0.0099
Treponema pallidum NADH oxidase 0.002 0.004 0.1749
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0236
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0061 0.2345
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.004 0.0268
Schistosoma mansoni hypothetical protein 0.001 0.001 0.0063
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0037 0.0436
Loa Loa (eye worm) globin family protein 0.001 0.001 0.0054
Loa Loa (eye worm) transcription factor SMAD2 0.0125 0.0376 0.3626
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0054
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0037 0.0063
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0037 0.0283
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0221 0.1424
Giardia lamblia DINP protein human, muc B family 0.0019 0.0037 0.1733
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0023 0.0049 0.3046
Toxoplasma gondii exonuclease III APE 0.0058 0.0162 0.4479
Onchocerca volvulus Huntingtin homolog 0.0128 0.0387 0.4934
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.0841 1
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0011 0.0011 0.0013
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0012 0.0014 0.0066
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0215 0.2073
Echinococcus granulosus lamin dm0 0.0033 0.0081 0.0495
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0033 0.0278
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0215 1
Schistosoma mansoni neutral sphingomyelinase 0.0012 0.0014 0.0093
Schistosoma mansoni alpha-glucosidase 0.0139 0.0422 0.2711
Trichomonas vaginalis helicase, putative 0.0014 0.0021 0.0243
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0037 0.0213
Onchocerca volvulus 0.0061 0.0171 0.2113
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0037 0.0028
Mycobacterium tuberculosis Isocitrate lyase Icl (isocitrase) (isocitratase) 0.3137 1 1
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0012 0.0014 0.0892
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0012 0.0014 0.0019
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0011 0.0081
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.0544 0.6465
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.002 0.004 0.5
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0014 0.0122
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0314 0.098 1
Entamoeba histolytica recQ family helicase, putative 0.0014 0.0021 0.1299
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0092 0.1083
Schistosoma mansoni hypothetical protein 0.0082 0.0239 0.1539
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0081 0.2076
Trichomonas vaginalis DNA helicase recq1, putative 0.0026 0.0059 0.0699
Loa Loa (eye worm) hypothetical protein 0.0074 0.0215 0.2049
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.002 0.004 0.0315
Onchocerca volvulus 0.0051 0.0141 0.1721
Mycobacterium ulcerans flavoprotein disulfide reductase 0.002 0.004 0.0031
Plasmodium vivax glutathione reductase, putative 0.0057 0.016 0.7249
Entamoeba histolytica sphingomyelinase C precursor, putative 0.0012 0.0014 0.0892
Brugia malayi Uncoordinated protein 44 0.0017 0.0033 0.0338
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0221 0.1424
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0021 0.0243
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0058 0.0162 0.0153
Plasmodium vivax SET domain protein, putative 0.0033 0.0081 0.3332
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0095 0.0586
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0081 0.0146
Schistosoma mansoni hypothetical protein 0.0012 0.0014 0.0093
Echinococcus granulosus dnaJ subfamily B 0.0494 0.1555 1
Trypanosoma brucei trypanothione reductase 0.0057 0.016 0.1503
Trichomonas vaginalis maltase-glucoamylase, putative 0.0013 0.002 0.0227
Schistosoma mansoni smad1 5 8 and 0.0009 0.0004 0.0028
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0054
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.027 0.0841 1
Loa Loa (eye worm) RecQ helicase 0.0026 0.0059 0.0537
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.002 0.004 0.0031
Loa Loa (eye worm) hypothetical protein 0.0016 0.0027 0.0224
Trichomonas vaginalis esterase, putative 0.0074 0.0215 0.2546
Entamoeba histolytica hypothetical protein 0.0037 0.0095 0.5871
Echinococcus multilocularis GPCR, family 2 0.0082 0.0239 0.0448
Brugia malayi beta-lactamase 0.0074 0.0215 0.2514
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0014 0.0101
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.044 0.043
Brugia malayi Pre-SET motif family protein 0.0219 0.0677 0.8045
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0149 0.0452 0.4529
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.016 0.7249
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0092 0.1083
Onchocerca volvulus 0.0074 0.0215 0.268
Trichomonas vaginalis DNA helicase recq, putative 0.0026 0.0059 0.0699
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.0393 0.0384
Schistosoma mansoni mixed-lineage leukemia protein mll 0.013 0.0393 0.2524
Schistosoma mansoni hypothetical protein 0.0344 0.1075 0.6916
Schistosoma mansoni hypothetical protein 0.0494 0.1555 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0017 0.0033 0.0338
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0215 0.2546
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0137 0.0415 0.4907
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0099
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0219 0.0677 0.6558
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0095 0.0173
Loa Loa (eye worm) hypothetical protein 0.0032 0.0079 0.073
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.016 0.1001
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0081 0.0919
Echinococcus multilocularis cpg binding protein 0.0064 0.0182 0.0339
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0013 0.002 0.1219
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0221 0.2117
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0012 0.0014 0.0892
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.005 0.3064
Trichomonas vaginalis set domain proteins, putative 0.0249 0.0773 0.9198
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0082 0.0239 0.1515
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.004 0.0315
Mycobacterium tuberculosis Conserved protein 0.0074 0.0215 0.0205
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0092 0.2389
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0081 0.0749
Schistosoma mansoni globin X 0.001 0.001 0.0063
Echinococcus multilocularis muscleblind protein 0.0145 0.0441 0.0831
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0037 0.2298
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0021 0.0116
Loa Loa (eye worm) hypothetical protein 0.0177 0.0544 0.5255
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.002 0.004 0.0069
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0004 0.0028
Mycobacterium tuberculosis Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) 0.3137 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0236
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0236
Echinococcus multilocularis synaptojanin 1 0.0012 0.0014 0.0019
Plasmodium vivax importin-beta 2, putative 0.0031 0.0076 0.3063
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0215 0.2546
Toxoplasma gondii thioredoxin reductase 0.0057 0.016 0.4398
Loa Loa (eye worm) histone methyltransferase 0.002 0.0041 0.0356
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0118 0.1073
Echinococcus multilocularis geminin 0.0344 0.1075 0.204
Echinococcus multilocularis snurportin 1 0.033 0.103 0.1954
Schistosoma mansoni hypothetical protein 0.0082 0.0239 0.1539
Schistosoma mansoni alpha glucosidase 0.0036 0.0092 0.059
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0021 0.0243
Echinococcus granulosus geminin 0.0344 0.1075 0.6907
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0014 0.0101
Schistosoma mansoni hypothetical protein 0.0017 0.0033 0.0209
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0092 0.1083
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.0544 0.6465
Loa Loa (eye worm) RNA binding protein 0.0076 0.0221 0.2117
Schistosoma mansoni synaptojanin 0.0012 0.0014 0.0093
Onchocerca volvulus 0.0094 0.0276 0.3482
Onchocerca volvulus 0.0033 0.0081 0.0934
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.0066
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0057 0.0672
Entamoeba histolytica Ran family GTPase 0.0023 0.005 0.3064
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.002 0.004 0.0031
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0014 0.0101
Plasmodium falciparum exodeoxyribonuclease III, putative 0.0012 0.0014 0.0892
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0014 0.0101
Plasmodium falciparum DNase I-like protein, putative 0.0012 0.0014 0.0892
Onchocerca volvulus 0.0012 0.0014 0.0061
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0012 0.0014 0.0164
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0058 0.0162 0.1572
Plasmodium falciparum thioredoxin reductase 0.0057 0.016 0.9833
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0012 0.0014 0.0892
Leishmania major pantothenate kinase subunit, putative 0.0012 0.0014 0.0048
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0081 0.0522
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.002 0.004 0.1291
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0012 0.0014 0.0164
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.004 0.0268
Plasmodium falciparum thioredoxin reductase 0.002 0.004 0.2485
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.005 0.0293
Onchocerca volvulus 0.0033 0.0081 0.0934
Echinococcus granulosus intermediate filament protein 0.0033 0.0081 0.0495
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.004 0.0268
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.0393 0.0384
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0082 0.0239 0.2809
Mycobacterium tuberculosis Probable reductase 0.013 0.0393 0.0384
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0221 0.2117
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0021 0.0243
Brugia malayi hypothetical protein 0.001 0.001 0.0066
Plasmodium falciparum glutathione reductase 0.0057 0.016 0.9833
Trichomonas vaginalis DNA helicase recq, putative 0.0014 0.0021 0.0243
Echinococcus granulosus dna polymerase eta 0.0019 0.0037 0.0213
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.027 0.0841 0.8151
Giardia lamblia Inositol 5-phosphatase 4 0.0012 0.0014 0.0225
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.0544 0.6465
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0057 0.0442
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.002 0.004 0.2485
Brugia malayi hypothetical protein 0.001 0.001 0.0066
Toxoplasma gondii NADPH-glutathione reductase 0.002 0.004 0.0866
Leishmania major endonuclease/exonuclease protein-like protein 0.0012 0.0014 0.0048
Leishmania major RNA-editing complex protein MP100, putative 0.0012 0.0014 0.0048
Echinococcus granulosus traf and tnf receptor associated protein 0.0012 0.0014 0.0066
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0149 0.0452 0.4529
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0037 0.0236
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0221 0.1424
Echinococcus granulosus death domain containing protein 0.0017 0.0033 0.0182
Mycobacterium ulcerans isocitrate lyase Icl 0.3137 1 1
Brugia malayi Thioredoxin reductase 0.0057 0.016 0.1856
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0021 0.0243
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1652 0.5255 1
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0012 0.0014 0.0892
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0037 0.0394
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0236
Loa Loa (eye worm) hypothetical protein 0.0259 0.0806 0.781
Leishmania major glycosyl hydrolase-like protein 0.0013 0.002 0.0103
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0037 0.0236
Leishmania major hypothetical protein, conserved 0.0012 0.0014 0.0048
Brugia malayi hypothetical protein 0.001 0.001 0.0066
Echinococcus multilocularis lysosomal alpha glucosidase 0.0162 0.0494 0.0932
Trichomonas vaginalis glutathione reductase, putative 0.002 0.004 0.0472
Brugia malayi Latrophilin receptor protein 2 0.0082 0.0239 0.2809
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.005 0.2556
Brugia malayi MH2 domain containing protein 0.0125 0.0376 0.4448
Echinococcus granulosus importin subunit beta 1 0.0031 0.0076 0.0461
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0042 0.0271
Echinococcus multilocularis lysosomal alpha glucosidase 0.0162 0.0494 0.0932
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.002 0.0055
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.002 0.004 0.1291
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0014 0.0122
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0314 0.098 1
Loa Loa (eye worm) beta-lactamase 0.0074 0.0215 0.2049
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.044 0.043
Schistosoma mansoni netrin receptor unc5 0.0017 0.0033 0.0209
Schistosoma mansoni hypothetical protein 0.0082 0.0239 0.1539
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0081 0.0522
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0314 0.098 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.005 0.0365
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0011 0.00000000045859
Plasmodium falciparum glutathione reductase 0.002 0.004 0.2485
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0012 0.0014 0.0164
Loa Loa (eye worm) hypothetical protein 0.0018 0.0033 0.028
Brugia malayi CCR4 0.0012 0.0014 0.0122
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0061 0.0486
Schistosoma mansoni hypothetical protein 0.0344 0.1075 0.6916
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0058 0.0162 0.1531
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0019 0.0043
Brugia malayi Glycosyl hydrolases family 31 protein 0.0013 0.002 0.0185
Schistosoma mansoni hypothetical protein 0.0012 0.0015 0.0096
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0081 0.0496
Brugia malayi hypothetical protein 0.001 0.001 0.0066
Echinococcus granulosus lamin 0.0033 0.0081 0.0495
Echinococcus multilocularis muscleblind protein 1 0.0145 0.0441 0.0831
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.0841 1
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0014 0.0122
Loa Loa (eye worm) hypothetical protein 0.0074 0.0215 0.2049
Schistosoma mansoni mixed-lineage leukemia protein mll 0.001 0.0009 0.0055
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0011 0.0011 0.0013
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.002 0.0227
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0037 0.0321
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.0544 0.6465
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.004 0.0268
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0092 0.0166
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.0841 1
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0014 0.0122
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0021 0.0243
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0037 0.0236
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0012 0.0014 0.0892
Brugia malayi Globin family protein 0.001 0.001 0.0066
Entamoeba histolytica inositol polyphosphate-5-phosphatase, putative 0.0012 0.0014 0.0892
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0054 0.0149 0.1393
Mycobacterium ulcerans beta-lactamase 0.0074 0.0215 0.0205
Trichomonas vaginalis ran, putative 0.0023 0.005 0.0584
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0021 0.0243
Schistosoma mansoni ap endonuclease 0.0058 0.0162 0.1043
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.004 0.0268
Brugia malayi beta-lactamase family protein 0.0074 0.0215 0.2514
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.016 0.0296
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0037 0.0236
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0029 0.0047
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.0393 0.0384
Loa Loa (eye worm) hypothetical protein 0.0033 0.0081 0.0749
Echinococcus granulosus tumor protein p63 0.0351 0.1099 0.7058
Schistosoma mansoni ran 0.0023 0.005 0.032
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.002 0.004 0.0866
Schistosoma mansoni alpha-glucosidase 0.0139 0.0422 0.2711
Echinococcus granulosus muscleblind protein 0.0145 0.0441 0.2815
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0076 0.0635
Leishmania major mitochondrial DNA polymerase beta 0.0314 0.098 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.0415 0.2667
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.0415 0.2667
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.0574 0.6828
Schistosoma mansoni hypothetical protein 0.0082 0.0239 0.1539
Brugia malayi Bloom's syndrome protein homolog 0.0026 0.0059 0.0659
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.004 0.0268
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0162 0.7384
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0092 0.1083
Loa Loa (eye worm) latrophilin receptor protein 2 0.0082 0.0239 0.229
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0076 0.1917
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.0415 0.2667
Toxoplasma gondii ABC1 family protein 0.0074 0.0215 0.603
Echinococcus granulosus Ankyrin 0.0018 0.0033 0.0185
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0215 0.2073
Loa Loa (eye worm) hypothetical protein 0.0074 0.0215 0.2049
Schistosoma mansoni synaptojanin 0.0012 0.0014 0.0093
Schistosoma mansoni cpg binding protein 0.0061 0.0171 0.1101
Echinococcus granulosus cpg binding protein 0.0064 0.0182 0.1148
Plasmodium falciparum importin beta, putative 0.0031 0.0076 0.467
Schistosoma mansoni Smad4 0.0009 0.0004 0.0028
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0118 0.1073
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0118 0.1073
Plasmodium falciparum endonuclease/exonuclease/phosphatase family protein, putative 0.0012 0.0014 0.0892
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0061 0.1491
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0082 0.0239 0.1515
Schistosoma mansoni myoglobin 1 0.001 0.001 0.0063
Brugia malayi hypothetical protein 0.0026 0.0061 0.0683
Brugia malayi TAR-binding protein 0.0076 0.0221 0.2597
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0137 0.0415 0.3999
Brugia malayi beta-lactamase family protein 0.0074 0.0215 0.2514
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0054
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0092 0.08
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0089 0.0261 0.0489
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0099
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0037 0.0436
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0118 0.1073
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0012 0.0014 0.0164
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.002 0.004 0.0268
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0017 0.0033 0.0054
Mycobacterium ulcerans isocitrate lyase AceAb 0.3137 1 1
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0018 0.0033 0.0212
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0137 0.0415 0.2646
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0092 0.0564
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0012 0.0014 0.0892
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0015 0.0024 0.023
Onchocerca volvulus Putative neutral sphingomyelinase 0.0012 0.0014 0.0061
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0012 0.0014 0.0019
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.002 0.0227
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0001 0.00000000016681
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0215 0.0205
Echinococcus multilocularis tumor protein p63 0.0351 0.1099 0.2085
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0012 0.0014 0.0019
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0215 0.2073
Schistosoma mansoni ankyrin 23/unc44 0.0017 0.0033 0.0209
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0012 0.0014 0.0892
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0149 0.0452 0.4555
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0215 0.0205
Mycobacterium tuberculosis Conserved hypothetical protein 0.0165 0.0505 0.0496
Mycobacterium tuberculosis Conserved protein 0.0074 0.0215 0.0205
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0061 0.3784
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0019 0.0043
Trypanosoma cruzi trypanothione reductase, putative 0.002 0.004 0.0268
Echinococcus multilocularis dna polymerase eta 0.0019 0.0037 0.0063
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0014 0.0122
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0215 0.04
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.002 0.0227
Leishmania major acetoin dehydrogenase e3 component-like protein 0.002 0.004 0.0315

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
IC50 (binding) = 4.2 ug ml-1 Inhibition of Candida albicans ICL assessed as formation of glyoxylate phenylhydrazone by spectrophotometry ChEMBL. 21377877
IC50 (binding) = 6.05 ug ml-1 Inhibition of Magnaporthe grisea isocitrate lyase ChEMBL. 18973387
IC50 (binding) = 6 uM Inhibition of Candida albicans isocitrate lyase after 30 mins ChEMBL. 22001028
IC50 (binding) = 9 uM Inhibition of Candida albicans isocitrate lyase ChEMBL. 21827183
IC50 (binding) = 13.91 uM Inhibition of recombinant Candida albicans ATCC 10231 ICL using phenylhydrazine and isocitrate as substrate assessed as formation of glyoxylate phenylhydrazone after 30 mins by spectrophotometric analysis ChEMBL. 23747224
IC50 (binding) = 17.27 uM Inhibition of Candida albicans ATCC 10231 isocitrate lyase ChEMBL. 25052426
IC50 (binding) = 38.6 uM Inhibition of Candida albicans recombinant ICL assessed as formation of glyoxylate phenylhydrazone by spectrophotometry ChEMBL. 22652254
IC50 (binding) = 50.7 uM Inhibition of candida albicans isocitrate lyase ChEMBL. 18824352
IC50 (binding) = 50.7 uM Inhibition of Candida albicans isocitrate lyase ChEMBL. 19167886
IC50 (binding) = 50.7 uM Inhibition of Candida albicans ATCC 10231 isocitrate lyase ChEMBL. 20888765
IC50 (binding) = 50.7 uM Inhibition of Mycobacterium tuberculosis recombinant isocitrate lyase expressed in Escherichia coli BL21 (DE3) using isocitrate as substrate after 10 mins by spectrometric analysis ChEMBL. No reference
IC50 (binding) = 51 uM Inhibition of Candida albicans isocitrate lyase ChEMBL. 21035332
IC50 (binding) = 53.9 uM Inhibition of Candida albicans ATCC 10231 isocitrate lyase by spectrophotometric analysis ChEMBL. 23145909
IC50 (binding) = 116 uM Inhibition of Mycobacterium tuberculosis isocitrate lyase ChEMBL. 21840711
IC50 (ADMET) = 692.5 uM Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by MTS assay ChEMBL. 24953953
IC50 (functional) = 845 uM Antifungal activity against candida albicans ATCC 10231 ChEMBL. 18824352
Inhibition (functional) Antifungal activity against Candida albicans ATCC 10231 at 100 ug/ml after 2 weeks ChEMBL. 21377877
Inhibition (binding) = 25 % Inhibition of Mycobacterium tuberculosis H37Rv isocitrate lyase expressed in Escherichia coli HB101 at 10 umol/L ChEMBL. 22960697
Inhibition (binding) = 63.2 % Percent inhibition of Mycobacterium tuberculosis isocitrate lyase (ICL) at 100 uM ChEMBL. 20615698
Inhibition (binding) = 65.99 % Inhibition of Mycobacterium tuberculosis isocitrate lyase at 100 mM ChEMBL. 21093117
Inhibition (binding) = 67 % Inhibition of Mycobacterium tuberculosis H37Rv isocitrate lyase expressed in Escherichia coli BL21(DE3) using (+)-potassium Ds-threo-isocitrate as substrate assessed as glyoxylate phenyl hydrazone formation at 100 umol/L by spectrophotometry ChEMBL. 22907036
MIC (functional) = 12.5 ug ml-1 Antimycobacterial activity against Mycobacterium tuberculosis H37Rv after 7 days by microplate Alamar blue assay ChEMBL. 25462220
MIC (functional) = 50 ug ml-1 Antimycobacterial activity against Mycobacterium tuberculosis H37Ra after 7 days by microplate Alamar blue assay ChEMBL. 25462220
MIC (functional) > 200 ug ml-1 Antifungal activity against Candida albicans SC5314 assessed as growth inhibition after 48 hrs in presence of 2% glucose ChEMBL. 23747224
MIC (functional) = 200 ug ml-1 Antifungal activity against Candida albicans SC5314 assessed as growth inhibition after 48 hrs in presence of 2% potassium acetate ChEMBL. 23747224
MIC (functional) = 3.3 uM Antimycobacterial activity against Mycobacterium tuberculosis H37Ra by microplate alamar blue assay ChEMBL. 16038559
MIC (functional) > 100 uM Antimycobacterial activity against Mycobacterium tuberculosis H37Rv 331/88 assessed as complete growth inhibition after 14 days ChEMBL. 24953953
MIC (functional) > 419.92 uM Antimycobacterial activity against 6-weeks nutrient starved phase cultures of Mycobacterium tuberculosis H37Rv treated for 7 days measured after 4 weeks by agar dilution method ChEMBL. 21840711
MIC (functional) > 419.92 uM Antimycobacterial activity against active log phase Mycobacterium tuberculosis H37Rv by agar dilution method ChEMBL. 21840711
MIC (functional) > 1000 uM Antimycobacterial activity against Mycobacterium tuberculosis H37Rv 331/88 assessed as complete growth inhibition after 21 days ChEMBL. 24953953
MIC (functional) > 1690 uM Antimicrobial activity against Candida albicans ATCC 10231 ChEMBL. 19167886
Potency (functional) = 0.0631 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of Acetylcholine Muscarinic M1 Receptor: Kinetic Measurement of Intracellular Calcium Response. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.1096 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the NFkB signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.5623 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.631 um PUBCHEM_BIOASSAY: qHTS Validation Assay for Inhibitors of Bloom's syndrome helicase (BLM). (Class of assay: confirmatory) [Related pubchem assays: 593 (Fluorescein region spectral profiling screen), 594 (Rhodamine region spectral profiling screen)] ChEMBL. No reference
Potency (functional) = 0.631 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM). (Class of assay: confirmatory) [Related pubchem assays: 593 (Fluorescein region spectral profiling screen), 2386 (Probe Development Summary for Inhibitors of Bloom's syndrome helicase (BLM)), 594 (Rhodamine region spectral profiling screen), 2364 (qHTS Validation Assay for Inhibitors of Bloom's syndrome helicase (BLM))] ChEMBL. No reference
Potency (functional) 0.7079 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 0.8199 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: Confirmation and Secondary Assay for Modulators of Hemoglobin Beta Chain Splicing at IVS2 654 locus. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Small Molecule Agonists for Hypoxia Response Element Signaling Pathway. (Class of assay: confirmatory) [Related pubchem assays: 915 ] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Small Molecule Antagonists for Hypoxia Response Element Signaling Pathway. (Class of assay: confirmatory) [Related pubchem assays: 914 ] ChEMBL. No reference
Potency (functional) 32.6427 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors: Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493163, AID504444, AID504648] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 56.7068 uM PubChem BioAssay: Tox21. qHTS assay for small molecule activators of the heat shock response signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 63.6261 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the AP-1 signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 70.7576 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Targets
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from specific protein inhibition (ECO:0000020) Mycobacterium tuberculosis 5624  
Annotator: crowther@u.washington.edu Comment: 2007-12-12 References: 10572116
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from specific protein inhibition (ECO:0000020) Mycobacterium tuberculosis 5625  
Annotator: crowther@u.washington.edu Comment: 2007-12-12 References: 10572116
growth (GO:0040007) decreased (PATO:0000468) inferred from in vitro culture assay (ECO:0000182) Mycobacterium tuberculosis 5624  
Annotator: crowther@u.washington.edu Comment: 2007-12-12 References: 15895072
growth (GO:0040007) decreased (PATO:0000468) inferred from in vitro culture assay (ECO:0000182) Mycobacterium tuberculosis 5625  
Annotator: crowther@u.washington.edu Comment: 2007-12-12 References: 15895072
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from specific protein inhibition (ECO:0000020) Mycobacterium tuberculosis 6243  
Annotator: crowther@u.washington.edu Comment: 2007-12-12 References: 10572116
growth (GO:0040007) decreased (PATO:0000468) inferred from in vitro culture assay (ECO:0000182) Mycobacterium tuberculosis 6243  
Annotator: crowther@u.washington.edu Comment: 2007-12-12 References: 10963599 15895072 16201909
response to drug (GO:0042493) decreased sensitivity toward (PATO:0001550) inferred from over expression (ECO:0000120) Mycobacterium tuberculosis 6243  
Annotator: crowther@u.washington.edu Comment: 2007-12-12 References: 15895072

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

22 literature references were collected for this gene.

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