Detailed information for compound 56654

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 427.624 | Formula: C29H37N3
  • H donors: 0 H acceptors: 0 LogP: 6.06 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: c1ccc(cc1)CCCN1CCN(CC1)CCCN(c1ccccc1)Cc1ccccc1
  • InChi: 1S/C29H37N3/c1-4-12-27(13-5-1)16-10-19-30-22-24-31(25-23-30)20-11-21-32(29-17-8-3-9-18-29)26-28-14-6-2-7-15-28/h1-9,12-15,17-18H,10-11,16,19-26H2
  • InChiKey: ZKMLAACIBJTRKI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0013 0.0012 0.0094
Brugia malayi steroid hormone receptor 0.003 0.0099 0.031
Onchocerca volvulus 0.0015 0.0023 0.003
Schistosoma mansoni cpg binding protein 0.003 0.01 0.023
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0018 0.0055
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0099 0.0228
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0133 0.2675
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0133 0.2675
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0099 0.0099
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.0018 0.0017
Mycobacterium ulcerans NAD-dependent aldehyde dehydrogenase AldA 0.0014 0.0017 0.0134
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0099 0.0099
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0035 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0035 0.0064
Mycobacterium tuberculosis Probable gamma-glutamyl phosphate reductase protein ProA (GPR) (glutamate-5-semialdehyde dehydrogenase) (glutamyl-gamma-semialde 0.0014 0.0017 0.0134
Mycobacterium ulcerans arylsulfatase AtsB 0.0017 0.0035 0.0278
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0035 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0035 0.0064
Echinococcus granulosus betaine aldehyde dehydrogenase 0.0014 0.0017 0.0017
Echinococcus granulosus nuclear receptor nhr 48 0.0014 0.0018 0.0017
Brugia malayi Zona pellucida-like domain containing protein 0.0036 0.0132 0.0414
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0013 0.0012 0.0011
Loa Loa (eye worm) RGS-3 protein 0.0039 0.0146 0.0446
Mycobacterium ulcerans arylsulfatase AtsD 0.0017 0.0035 0.0278
Brugia malayi hypothetical protein 0.0017 0.0035 0.0109
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0023 0.0068
Loa Loa (eye worm) hypothetical protein 0.0039 0.0146 0.0446
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0099 0.0228
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0014 0.0017 0.035
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0014 0.0017 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0099 0.031
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0099 0.031
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.0497 1
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0013 0.0012 0.0011
Brugia malayi Sulfatase family protein 0.0017 0.0035 0.0109
Onchocerca volvulus 0.0015 0.0023 0.003
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0013 0.0012 0.0011
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0023 0.0068
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0044 0.0175 0.0534
Loa Loa (eye worm) cytochrome P450 family protein 0.0068 0.0298 0.091
Loa Loa (eye worm) hypothetical protein 0.009 0.0413 0.1262
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.009 0.0413 0.0412
Echinococcus multilocularis aminopeptidase N 0.0013 0.0012 0.0011
Brugia malayi hypothetical protein 0.0016 0.0027 0.0082
Echinococcus granulosus leukotriene A 4 hydrolase 0.024 0.1197 0.1197
Onchocerca volvulus 0.003 0.01 0.0244
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0087 0.0696
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0251 0.1251 0.125
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0052 0.0051
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0052 0.0051
Toxoplasma gondii hypothetical protein 0.0015 0.0023 0.0182
Loa Loa (eye worm) hypothetical protein 0.0039 0.0146 0.0446
Mycobacterium tuberculosis Probable methylmalonate-semialdehyde dehydrogenase MmsA (methylmalonic acid semialdehyde dehydrogenase) (MMSDH) 0.0014 0.0017 0.0134
Mycobacterium ulcerans aldehyde dehydrogenase (NAD+) dependent 0.0014 0.0017 0.0134
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0094 0.0755
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0013 0.0012 0.0011
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0013 0.0012 0.0026
Plasmodium falciparum von Willebrand factor A domain-related protein 0.0036 0.0132 0.8295
Schistosoma mansoni hypothetical protein 0.0454 0.2307 0.5326
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0099 0.0302
Entamoeba histolytica hypothetical protein 0.0039 0.0146 0.2941
Brugia malayi hypothetical protein 0.0039 0.0146 0.0457
Schistosoma mansoni delta 1-pyrroline-5-carboxylate synthetase 0.0014 0.0017 0.0039
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0133 0.0335
Mycobacterium ulcerans sulfatase 0.0017 0.0035 0.0278
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0087 0.211
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0133 0.1062
Loa Loa (eye worm) hypothetical protein 0.0036 0.0132 0.0403
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0878 0.4518 0.4518
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0099 0.0302
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.1145 0.1144
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0014 0.0017 0.0344
Schistosoma mansoni DNA helicase recq1 0.0021 0.0052 0.0119
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0087 0.5175
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0023 0.0182
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.0497 0.1145
Echinococcus multilocularis musashi 0.0082 0.0374 0.0373
Trypanosoma brucei cytochrome P450, putative 0.0011 0.0001 0.0007
Loa Loa (eye worm) hypothetical protein 0.0016 0.0027 0.008
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.019 0.0596
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.01 0.0306
Loa Loa (eye worm) hypothetical protein 0.003 0.0099 0.0302
Loa Loa (eye worm) hypothetical protein 0.0014 0.0018 0.0054
Entamoeba histolytica elongation factor-2 kinase, putative 0.0036 0.0132 0.2663
Toxoplasma gondii microneme protein MIC17A 0.0015 0.0023 0.0182
Schistosoma mansoni cpg binding protein 0.0031 0.0109 0.0251
Schistosoma mansoni DNA helicase recq5 0.0021 0.0052 0.0119
Brugia malayi von Willebrand factor type A domain containing protein 0.0036 0.0132 0.0414
Echinococcus granulosus dnaJ subfamily B 0.0423 0.215 0.2149
Loa Loa (eye worm) hypothetical protein 0.0081 0.0366 0.112
Trypanosoma cruzi aminopeptidase, putative 0.0013 0.0012 0.0237
Loa Loa (eye worm) hypothetical protein 0.023 0.1145 0.3506
Loa Loa (eye worm) hypothetical protein 0.0036 0.0132 0.0403
Loa Loa (eye worm) hypothetical protein 0.0014 0.0018 0.0054
Brugia malayi Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor 0.0014 0.0017 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0035 0.0064
Schistosoma mansoni serine-rich repeat protein 0.0454 0.2307 0.5326
Brugia malayi Kringle domain containing protein 0.0023 0.0065 0.0202
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.024 0.1197 0.2763
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.0497 1
Schistosoma mansoni aminopeptidase A (M01 family) 0.0013 0.0012 0.0026
Loa Loa (eye worm) hypothetical protein 0.0039 0.0146 0.0446
Schistosoma mansoni rotamase 0.0035 0.0126 0.0288
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0014 0.0017 0.0017
Echinococcus multilocularis axis inhibition protein axin 0.0039 0.0146 0.0145
Brugia malayi von Willebrand factor type A domain containing protein 0.0036 0.0132 0.0414
Mycobacterium ulcerans aminopeptidase N PepN 0.0013 0.0012 0.0091
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0013 0.0012 0.0237
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.0497 1
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.0036 0.0132 0.3207
Entamoeba histolytica hypothetical protein 0.0039 0.0146 0.2941
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0021 0.0052 0.0052
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0099 0.0099
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0035 0.0064
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0146 0.0336
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0256 0.2046
Leishmania major aldehyde dehydrogenase, putative 0.0014 0.0017 0.0137
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0027 0.0082
Onchocerca volvulus 0.0047 0.019 0.0492
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0013 0.0012 0.0237
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0052 0.0051
Schistosoma mansoni axis inhibition protein axin 0.0039 0.0146 0.0336
Loa Loa (eye worm) hypothetical protein 0.0036 0.0133 0.0406
Brugia malayi von Willebrand factor type A domain containing protein 0.0036 0.0132 0.0414
Entamoeba histolytica hypothetical protein 0.0036 0.0132 0.2663
Brugia malayi hypothetical protein 0.0245 0.1219 0.383
Loa Loa (eye worm) hypothetical protein 0.0039 0.0146 0.0446
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0099 0.031
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0041 0.0157 0.0156
Toxoplasma gondii aldehyde dehydrogenase 0.0251 0.1251 1
Onchocerca volvulus 0.0082 0.0374 0.1001
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0023 0.0065 0.0197
Brugia malayi Pre-SET motif family protein 0.009 0.0413 0.1295
Echinococcus multilocularis dnaJ subfamily B 0.0423 0.215 0.2149
Onchocerca volvulus 0.0707 0.3628 1
Brugia malayi intermediate filament protein 0.0082 0.0374 0.1173
Mycobacterium ulcerans pyrroline-5-carboxylate dehydrogenase, RocA 0.0014 0.0017 0.0134
Brugia malayi PAN domain containing protein 0.0015 0.0023 0.007
Loa Loa (eye worm) phosphofructokinase 0.0106 0.0497 0.152
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0146 0.0371
Loa Loa (eye worm) hypothetical protein 0.0036 0.0132 0.0403
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0133 0.0132
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0013 0.0012 0.0094
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0291 0.067
Echinococcus multilocularis thyroid hormone receptor alpha 0.0296 0.1484 0.1484
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0021 0.0052 0.0052
Onchocerca volvulus 0.0015 0.0023 0.003
Loa Loa (eye worm) hypothetical protein 0.0014 0.0018 0.0054
Schistosoma mansoni hypothetical protein 0.0036 0.0132 0.0304
Brugia malayi CXXC zinc finger family protein 0.003 0.01 0.0313
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0041 0.0157 0.3157
Brugia malayi ecdysteroid receptor 0.003 0.0099 0.031
Trichomonas vaginalis rotamase, putative 0.0035 0.0126 0.0314
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0013 0.0012 0.0237
Echinococcus multilocularis voltage dependent calcium channel subunit 0.1931 1 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0027 0.008
Brugia malayi nuclear hormone receptor 0.003 0.0099 0.031
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0014 0.0018 0.004
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0094 0.5685
Mycobacterium tuberculosis Possible succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD2 0.0014 0.0017 0.0134
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0146 0.0371
Echinococcus multilocularis 6 phosphofructokinase 0.0106 0.0497 0.0496
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0021 0.0052 0.0052
Entamoeba histolytica aminopeptidase, putative 0.0013 0.0012 0.0243
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0099 0.0099
Echinococcus granulosus survival motor neuron protein 1 0.023 0.1145 0.1144
Toxoplasma gondii microneme protein MIC17B 0.0015 0.0023 0.0182
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0035 0.0064
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0013 0.0012 0.0011
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0013 0.0012 0.0011
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0146 0.0336
Echinococcus multilocularis expressed protein 0.075 0.385 0.3849
Entamoeba histolytica aldehyde dehydrogenase 1, putative 0.0014 0.0017 0.035
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0035 0.0064
Brugia malayi von Willebrand factor type A domain containing protein 0.0036 0.0132 0.0414
Loa Loa (eye worm) peptidase family M1 containing protein 0.0013 0.0012 0.0035
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0121 0.2438
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0266 0.1331 0.133
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0014 0.0017 0.0344
Mycobacterium ulcerans gamma-glutamyl phosphate reductase 0.0014 0.0017 0.0134
Onchocerca volvulus 0.002 0.0052 0.011
Onchocerca volvulus 0.0014 0.0018 0.0017
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0041 0.0157 0.1251
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0009 0.0008
Echinococcus multilocularis tissue type plasminogen activator 0.0023 0.0065 0.0064
Echinococcus granulosus Regulator of G protein signaling 20 0.0039 0.0146 0.0145
Loa Loa (eye worm) hypothetical protein 0.0016 0.0027 0.008
Plasmodium vivax thrombospondin-related anonymous protein 0.0036 0.0132 0.3207
Brugia malayi Aldehyde dehydrogenase protein 4 0.0014 0.0017 0.0053
Onchocerca volvulus 0.0036 0.0132 0.0333
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0146 0.0336
Echinococcus multilocularis RUN 0.002 0.0052 0.0051
Loa Loa (eye worm) hypothetical protein 0.0014 0.0018 0.0054
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0035 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0035 0.0064
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0013 0.0012 0.0237
Loa Loa (eye worm) DR-78 0.0014 0.0018 0.0054
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0014 0.0017 0.0344
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0621 0.3181 0.9747
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0041 0.0157 0.3161
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase 0.0014 0.0017 0.0134
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0013 0.0012 0.0094
Loa Loa (eye worm) doublecortin family protein 0.002 0.0052 0.0157
Echinococcus multilocularis pikachurin 0.0023 0.0067 0.0066
Onchocerca volvulus 0.0015 0.0023 0.003
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0099 0.0228
Trypanosoma cruzi cytochrome P450, putative 0.0011 0.0001 0.0007
Schistosoma mansoni aldehyde dehydrogenase 0.0014 0.0017 0.0039
Entamoeba histolytica hypothetical protein, conserved 0.0036 0.0132 0.2663
Mycobacterium ulcerans piperideine-6-carboxilic acid dehydrogenase Pcd 0.0014 0.0017 0.0134
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0094 0.5
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0014 0.0018 0.0017
Mycobacterium ulcerans arylsulfatase, AslA 0.0017 0.0035 0.0278
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0052 0.0052
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0133 0.0416
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0839 0.4316 0.4315
Onchocerca volvulus 0.0023 0.0065 0.0146
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0413 0.0951
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0035 0.0064
Trichomonas vaginalis rotamase, putative 0.0034 0.0121 0.0302
Brugia malayi Regulator of G protein signaling domain containing protein 0.0039 0.0146 0.0457
Toxoplasma gondii cytochrome p450 superfamily protein 0.0011 0.0001 0.0005
Schistosoma mansoni z-protein (S1r protein) 0.0039 0.0146 0.0336
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0099 0.031
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0035 0.0064
Mycobacterium ulcerans hydrolase 0.0017 0.0035 0.0278
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 0.0014 0.0017 0.0134
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0094 0.0228
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.001 0.001
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0099 0.0302
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0027 0.0082
Entamoeba histolytica hypothetical protein 0.0039 0.0148 0.297
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0035 0.0064
Echinococcus multilocularis neurogenic locus notch protein 0.0023 0.0067 0.0066
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0106 0.0497 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0041 0.0157 0.0343
Echinococcus granulosus 6 phosphofructokinase 0.0106 0.0497 0.0496
Echinococcus multilocularis cpg binding protein 0.0031 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.003 0.0099 0.0302
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0039 0.0146 0.0446
Schistosoma mansoni hypothetical protein 0.0047 0.019 0.0438
Loa Loa (eye worm) hypothetical protein 0.0014 0.0018 0.0054
Loa Loa (eye worm) leukotriene A4 hydrolase 0.024 0.1197 0.3667
Onchocerca volvulus 0.009 0.0413 0.1108
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0014 0.0018 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0146 0.0371
Brugia malayi laminin alpha chain 0.0023 0.0067 0.0207
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.009 0.0413 0.0951
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.004 0.0152 0.0152
Onchocerca volvulus Aldehyde dehydrogenase homolog 0.0014 0.0017 0.0015
Brugia malayi Zona pellucida-like domain containing protein 0.0036 0.0132 0.0414
Loa Loa (eye worm) hypothetical protein 0.0036 0.0132 0.0403
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0013 0.0012 0.0011
Onchocerca volvulus 0.0053 0.0223 0.0584
Brugia malayi 6-phosphofructokinase 0.0106 0.0497 0.156
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0035
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0011 0.0001 0.0007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0099 0.0302
Onchocerca volvulus 0.0036 0.0132 0.0333
Loa Loa (eye worm) hypothetical protein 0.003 0.0099 0.0302
Brugia malayi Pre-SET motif family protein 0.0621 0.3181 1
Echinococcus granulosus tumor protein p63 0.0364 0.1842 0.1842
Echinococcus granulosus histone lysine methyltransferase setb 0.009 0.0413 0.0412
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.0011 0 0.0002
Loa Loa (eye worm) CUTiclin-Like family member 0.0036 0.0132 0.0403
Leishmania major ATP-dependent phosphofructokinase 0.0106 0.0497 0.397
Schistosoma mansoni aldehyde dehydrogenase 0.0014 0.0017 0.0039
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0035 0.0126 0.0383
Loa Loa (eye worm) hypothetical protein 0.0014 0.0017 0.0051
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0014 0.0018 0.0054
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0041 0.0157 0.0156
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0035
Mycobacterium tuberculosis Probable aldehyde dehydrogenase AldC 0.0014 0.0017 0.0134
Toxoplasma gondii peptidylprolyl isomerase 0.0034 0.0121 0.097
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0057 0.0243 0.0242
Mycobacterium tuberculosis Possible arylsulfatase AtsA (aryl-sulfate sulphohydrolase) (arylsulphatase) 0.0017 0.0035 0.0278
Loa Loa (eye worm) hypothetical protein 0.0036 0.0132 0.0403
Brugia malayi tailless protein 0.0014 0.0018 0.0055
Schistosoma mansoni lamin 0.0082 0.0374 0.0862
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0023 0.0068
Loa Loa (eye worm) hypothetical protein 0.0014 0.0018 0.0054
Plasmodium vivax SET domain protein, putative 0.009 0.0413 1
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0018 0.004
Echinococcus granulosus axis inhibition protein axin 0.0039 0.0146 0.0145
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0148 0.0339
Brugia malayi von Willebrand factor type A domain containing protein 0.0036 0.0132 0.0414
Echinococcus multilocularis beta adrenergic receptor kinase 0.0039 0.0146 0.0145
Echinococcus multilocularis regulator of G protein signaling 7 0.0039 0.0146 0.0145
Brugia malayi ecdysone receptor 0.0014 0.0018 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0035 0.0064
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase 0.0014 0.0017 0.0134
Schistosoma mansoni hypothetical protein 0.0036 0.0132 0.0304
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0133 0.0306
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0266 0.1331 0.133
Brugia malayi nuclear hormone receptor family member odr-7 0.0014 0.0018 0.0055
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0011 0.0001 0.0007
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.0497 0.152
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0133 0.2675
Brugia malayi von Willebrand factor type A domain containing protein 0.0036 0.0132 0.0414
Loa Loa (eye worm) hypothetical protein 0.0014 0.0018 0.0054
Schistosoma mansoni rab6-interacting 0.002 0.0052 0.0118
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0094 0.229
Mycobacterium ulcerans arylsulfatase AtsD 0.0017 0.0035 0.0278
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0014 0.0017 0.0344
Brugia malayi PAN domain containing protein 0.0015 0.0023 0.007
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0039 0.0146 0.0336
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0014 0.0017 0.0344
Brugia malayi Peptidase family M1 containing protein 0.0013 0.0012 0.0036
Loa Loa (eye worm) hypothetical protein 0.0014 0.0017 0.0051
Mycobacterium tuberculosis Possible arylsulfatase AtsD (aryl-sulfate sulphohydrolase) (arylsulphatase) 0.0017 0.0035 0.0278
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0039 0.0146 0.0446
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0035 0.0064
Schistosoma mansoni succinate semialdehyde dehydrogenase 0.0014 0.0017 0.0039
Onchocerca volvulus 0.002 0.0052 0.011
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0425 0.2157 0.4978
Echinococcus multilocularis betaine aldehyde dehydrogenase 0.0014 0.0017 0.0017
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0099 0.0228
Brugia malayi hypothetical protein 0.002 0.0052 0.0161
Brugia malayi A-kinase anchor protein 10, precursor 0.0039 0.0146 0.0457
Brugia malayi Peptidase family M1 containing protein 0.0013 0.0012 0.0036
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0011 0.0001 0.0001
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0023 0.0182
Loa Loa (eye worm) hypothetical protein 0.0038 0.0144 0.0441
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0157 0.0401
Loa Loa (eye worm) hypothetical protein 0.0014 0.0018 0.0054
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0413 0.0951
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0052 0.0163
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0094 0.0228
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0148 0.0147
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0099 0.031
Loa Loa (eye worm) PXA domain-containing protein 0.0039 0.0146 0.0446
Mycobacterium ulcerans aldehyde dehydrogenase 0.0251 0.1251 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0027 0.008
Loa Loa (eye worm) hypothetical protein 0.0036 0.0132 0.0403
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0099 0.031
Schistosoma mansoni hypothetical protein 0.0175 0.0859 0.1981
Wolbachia endosymbiont of Brugia malayi bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase 0.0014 0.0017 0.109
Mycobacterium ulcerans methylmalonate semialdehyde dehydrogenase, MmsA 0.0014 0.0017 0.0134
Loa Loa (eye worm) nuclear hormone receptor 0.0014 0.0018 0.0054
Brugia malayi hypothetical protein 0.0014 0.0018 0.0055
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0018 0.0017
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0023 0.0065 0.1574
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0027 0.008
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0052 0.0111
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0014 0.0017 0.0344
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0052 0.0051
Schistosoma mansoni hypothetical protein 0.0014 0.0017 0.0039
Brugia malayi EGF-like domain containing protein 0.0023 0.0067 0.0207
Mycobacterium ulcerans aldehyde dehydrogenase 0.0251 0.1251 1
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase [NADP+] dependent, GabD1 0.0014 0.0017 0.0134
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0094 0.5685
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0014 0.0017 0.0134
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0099 0.0099
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0099 0.0099
Schistosoma mansoni lipoxygenase 0.0057 0.0243 0.056
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.0497 0.152
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0014 0.0017 0.0344
Brugia malayi PAN domain containing protein 0.0015 0.0023 0.007
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0087 0.1748
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0014 0.0017 0.0344
Loa Loa (eye worm) hypothetical protein 0.0014 0.0018 0.0054
Toxoplasma gondii exonuclease III APE 0.0041 0.0157 0.1255
Loa Loa (eye worm) histone methyltransferase 0.0012 0.001 0.003
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0027 0.0026
Treponema pallidum methyl-accepting chemotaxis protein (mcp2-1) 0.0795 0.4084 1
Echinococcus granulosus bloom syndrome protein 0.0021 0.0052 0.0052
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0023 0.0067 0.0152
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0842 0.4332 1
Echinococcus granulosus regulator of G protein signaling 3 0.0039 0.0146 0.0145
Echinococcus granulosus FTZ F1 alpha 0.003 0.0099 0.0099
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0023 0.0068
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0099 0.0302
Echinococcus granulosus expressed protein 0.0035 0.0126 0.0125
Schistosoma mansoni laminin gamma-3 chain 0.0023 0.0067 0.0152
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0035 0.0064
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0035
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0023 0.0068
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0099 0.0099
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0052 0.0051
Mycobacterium ulcerans 6-phosphofructokinase 0.0106 0.0497 0.3969
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0099 0.031
Echinococcus granulosus lamin 0.0082 0.0374 0.0373
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0133 0.0335
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0133 0.0132
Brugia malayi Cytochrome P450 family protein 0.0068 0.0298 0.0934
Echinococcus multilocularis tumor protein p63 0.0364 0.1842 0.1842
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.0497 0.134
Echinococcus granulosus neurogenic locus notch protein 0.0023 0.0067 0.0066
Schistosoma mansoni thyroid hormone receptor 0.0296 0.1484 0.3426
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0146 0.0371
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0023 0.0182
Toxoplasma gondii methylmalonate-semialdehyde dehydrogenase [acylating], putative 0.0014 0.0017 0.0139
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0133 0.2679
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.0036 0.0132 0.3207
Echinococcus multilocularis collagen alpha 1(VII) chain 0.0036 0.0132 0.0132
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0251 0.1251 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.023 0.1145 0.3506
Onchocerca volvulus 0.0036 0.0132 0.0333
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0011 0.0001 0.0007
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.0497 0.134
Echinococcus multilocularis regulator of G protein signaling 0.0039 0.0146 0.0145
Echinococcus granulosus voltage dependent calcium channel subunit 0.0878 0.4518 0.4518
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0251 0.1251 1
Brugia malayi PAN domain containing protein 0.0015 0.0023 0.007
Onchocerca volvulus 0.0036 0.0132 0.0333
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0018 0.004
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0027 0.006
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0052 0.0111
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0052 0.2743
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0035 0.0064
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0013 0.0012 0.0237
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0052 0.0111
Trichomonas vaginalis mucin-desulfating sulfatase, putative 0.0017 0.0035 0.0064
Loa Loa (eye worm) hypothetical protein 0.0023 0.0067 0.0202
Echinococcus granulosus lamin dm0 0.0082 0.0374 0.0373
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.009 0.0413 0.0412
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0023 0.0182
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0094 0.0755
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0034 0.0121 0.2438
Trypanosoma brucei Aminopeptidase M1, putative 0.0013 0.0012 0.0237
Echinococcus granulosus beta-adrenergic receptor kinase 0.0039 0.0146 0.0145
Loa Loa (eye worm) hypothetical protein 0.003 0.0099 0.0302
Trypanosoma brucei delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0014 0.0017 0.0344
Schistosoma mansoni intermediate filament proteins 0.0082 0.0374 0.0862
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0039 0.0146 0.0336
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0099 0.0228
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0021 0.0052 0.0159
Loa Loa (eye worm) hypothetical protein 0.0023 0.0067 0.0202
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0094 0.5521
Loa Loa (eye worm) RecQ helicase 0.0021 0.0052 0.0159
Schistosoma mansoni coup transcription factor 0.003 0.0099 0.0228
Brugia malayi hypothetical protein 0.0013 0.0012 0.0036
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0021 0.0052 0.2781
Brugia malayi nuclear hormone receptor 0.0014 0.0018 0.0055
Schistosoma mansoni hypothetical protein 0.002 0.0052 0.0118
Toxoplasma gondii microneme protein MIC4 0.0015 0.0023 0.0182
Loa Loa (eye worm) hypothetical protein 0.0014 0.0018 0.0054
Loa Loa (eye worm) hypothetical protein 0.004 0.0152 0.0465
Schistosoma mansoni polycystin 1-related 0.002 0.0052 0.0118
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0087 0.1748
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0099 0.0241
Loa Loa (eye worm) hypothetical protein 0.0637 0.3264 1
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0013 0.0012 0.0094
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0106 0.0497 0.3969
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0094 0.0228
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0013 0.0012 0.0011
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0086 0.0392 0.0391
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0035 0.0064
Echinococcus granulosus collagen alpha 1VII chain 0.0036 0.0132 0.0132
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0035 0.0064
Mycobacterium tuberculosis Probable sulfatase 0.0017 0.0035 0.0278
Echinococcus granulosus cpg binding protein 0.0031 0.0109 0.0109
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0099 0.0302
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0014 0.0017 0.035
Echinococcus granulosus expressed protein 0.075 0.385 0.3849
Toxoplasma gondii hypothetical protein 0.0015 0.0023 0.0182
Brugia malayi PAN domain containing protein 0.0015 0.0023 0.007
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0014 0.0017 0.0344
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0039 0.0146 0.0371
Loa Loa (eye worm) hypothetical protein 0.0036 0.0132 0.0403
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0035 0.0064
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.0497 0.1145
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0133 0.8286
Schistosoma mansoni rab6-interacting 0.002 0.0052 0.0118
Trypanosoma brucei Aminopeptidase M1, putative 0.0013 0.0012 0.0237
Toxoplasma gondii gamma-glutamyl phosphate reductase, putative 0.0014 0.0017 0.0139
Leishmania major delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0014 0.0017 0.0137
Toxoplasma gondii subtilisin SUB12 0.0015 0.0023 0.0182
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0039 0.0146 0.0336
Brugia malayi hypothetical protein 0.0039 0.0148 0.0462
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0035 0.0064
Plasmodium falciparum cysteine repeat modular protein 1 0.0023 0.0065 0.3648
Echinococcus multilocularis aldehyde dehydrogenase family 3 member B1 0.0014 0.0017 0.0017
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0041 0.0157 0.0479
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.0018 0.0017
Schistosoma mansoni loxhd1 0.002 0.0052 0.0118
Onchocerca volvulus 0.0015 0.0023 0.003
Mycobacterium leprae PROBABLE ALDEHYDE DEHYDROGENASE (NAD+) DEPENDENT 0.0014 0.0017 0.0338
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.0497 1
Schistosoma mansoni hypothetical protein 0.0012 0.0009 0.0019
Loa Loa (eye worm) nuclear receptor NHR-67 0.0014 0.0018 0.0054
Entamoeba histolytica hypothetical protein 0.0039 0.0146 0.2941
Mycobacterium leprae PROBABLE GAMMA-GLUTAMYL PHOSPHATE REDUCTASE PROTEIN PROA (GPR) (GLUTAMATE-5-SEMIALDEHYDE DEHYDROGENASE) (GLUTAMYL-GAMMA-SEMIALDE 0.0014 0.0017 0.0338
Schistosoma mansoni hypothetical protein 0.0175 0.0859 0.1981
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.0497 0.134
Echinococcus granulosus regulator of G protein signaling 7 0.0039 0.0146 0.0145
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0099 0.031
Schistosoma mansoni nuclear receptor 0.0014 0.0018 0.004
Schistosoma mansoni aldehyde dehydrogenase 0.0014 0.0017 0.0039
Toxoplasma gondii microneme protein, putative 0.0015 0.0023 0.0182
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0057 0.0243 0.0242
Schistosoma mansoni nuclear receptor nhr-48 0.0014 0.0018 0.004
Loa Loa (eye worm) hypothetical protein 0.0082 0.0374 0.1144
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0157 0.3806
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0015 0.0023 0.0182
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0035 0.0126 0.0393
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0013 0.0012 0.0292
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0052 0.0051
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0052 0.0163
Brugia malayi 6-phosphofructokinase 0.0106 0.0497 0.156
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0041 0.0157 0.1251
Toxoplasma gondii microneme protein MIC2 0.0036 0.0132 0.1058
Brugia malayi nuclear receptor NHR-67 0.0014 0.0018 0.0055
Loa Loa (eye worm) intermediate filament protein 0.0082 0.0374 0.1144
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0014 0.0018 0.004
Toxoplasma gondii microneme protein MIC17C 0.0015 0.0023 0.0182
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0133 0.0132
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0099 0.0099
Brugia malayi hypothetical protein 0.0039 0.0146 0.0457
Treponema pallidum hypothetical protein 0.0036 0.0132 0.0283
Loa Loa (eye worm) abnormal epIthelia family member 0.0023 0.0067 0.0202
Echinococcus multilocularis regulator of G protein signaling 3 0.0039 0.0146 0.0145
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0052 0.0163
Loa Loa (eye worm) hypothetical protein 0.0389 0.197 0.6035
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0099 0.0099
Trypanosoma cruzi aminopeptidase, putative 0.0013 0.0012 0.0237
Brugia malayi regulator of G-protein signaling rgs-7 0.0039 0.0146 0.0457
Loa Loa (eye worm) hypothetical protein 0.0017 0.0035 0.0106
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0146 0.0371
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0013 0.0012 0.0011
Onchocerca volvulus GPI ethanolamine phosphate transferase 1 homolog 0.0017 0.0035 0.0064
Loa Loa (eye worm) aldehyde dehydrogenase 4 0.0014 0.0017 0.0051
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0052 0.1049
Brugia malayi Doublecortin family protein 0.002 0.0052 0.0161
Entamoeba histolytica recQ family helicase, putative 0.0021 0.0052 0.1054
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0132 0.3207
Brugia malayi PAN domain containing protein 0.0015 0.0023 0.007
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0094 0.0228
Schistosoma mansoni aldehyde dehydrogenase 0.0014 0.0017 0.0039
Onchocerca volvulus 0.0014 0.0018 0.0017
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0039 0.0146 0.0145
Echinococcus granulosus regulator of G protein signaling 3 0.0039 0.0146 0.0145
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0099 0.0241
Toxoplasma gondii aldehyde dehydrogenase (NAD) family protein 0.0014 0.0017 0.0139
Brugia malayi PAN domain containing protein 0.0015 0.0023 0.007
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0099 0.031
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0099 0.031
Loa Loa (eye worm) hypothetical protein 0.0023 0.0067 0.0202
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.002 0.0052 0.0157
Brugia malayi Cache domain containing protein 0.0389 0.197 0.6192
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0094 0.0755
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0035 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0146 0.0371
Echinococcus granulosus intermediate filament protein 0.0082 0.0374 0.0373
Schistosoma mansoni hypothetical protein 0.0023 0.0065 0.0148
Loa Loa (eye worm) hypothetical protein 0.002 0.0052 0.0157
Echinococcus granulosus regulator of G protein signaling 7 0.0039 0.0146 0.0145
Mycobacterium ulcerans gamma-aminobutyraldehyde dehydrogenase 0.0014 0.0017 0.0134
Loa Loa (eye worm) aminopeptidase N 0.0013 0.0012 0.0035
Brugia malayi hypothetical protein 0.0013 0.0012 0.0036
Leishmania major aldehyde dehydrogenase, putative 0.0014 0.0017 0.0137
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0099 0.031
Mycobacterium tuberculosis Probable pyrroline-5-carboxylate dehydrogenase RocA 0.0014 0.0017 0.0134
Brugia malayi nuclear receptor NHR-88 0.003 0.0099 0.031
Loa Loa (eye worm) hypothetical protein 0.0014 0.0018 0.0054
Loa Loa (eye worm) hypothetical protein 0.0036 0.0132 0.0403
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0157 0.0401
Brugia malayi hypothetical protein 0.0018 0.0037 0.0114
Echinococcus multilocularis lamin dm0 0.0082 0.0374 0.0373
Loa Loa (eye worm) hypothetical protein 0.0036 0.0132 0.0403
Loa Loa (eye worm) delta-1-pyrroline-5-carboxylate dehydrogenase 0.0014 0.0017 0.0051
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0014 0.0017 0.0344
Brugia malayi exodeoxyribonuclease III family protein 0.0041 0.0157 0.0492
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0052 0.1256
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0133 0.0132
Brugia malayi PXA domain containing protein 0.0039 0.0146 0.0457
Brugia malayi PAN domain containing protein 0.0015 0.0023 0.007
Onchocerca volvulus 0.0015 0.0023 0.003
Echinococcus multilocularis Regulator of G protein signaling 20 0.0039 0.0146 0.0145
Brugia malayi Regulator of G protein signaling domain containing protein 0.0039 0.0146 0.0457
Brugia malayi hypothetical protein 0.023 0.1145 0.3597
Giardia lamblia Hypothetical protein 0.0017 0.0035 0.1286
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0157 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0099 0.0228
Schistosoma mansoni survival motor neuron protein 0.0047 0.019 0.0438
Echinococcus multilocularis axis inhibition protein axin 0.0039 0.0146 0.0145
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0094 0.019
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0014 0.0017 0.0344
Echinococcus granulosus Fatty aldehyde dehydrogenase 0.0014 0.0017 0.0017
Brugia malayi nuclear receptor RXR 0.0016 0.0027 0.0082
Loa Loa (eye worm) hypothetical protein 0.0015 0.0023 0.0068
Schistosoma mansoni hypothetical protein 0.0039 0.0148 0.0339
Mycobacterium tuberculosis Possible hydrolase 0.0017 0.0035 0.0278
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0014 0.0017 0.0344
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.009 0.0413 0.3299
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0099 0.0099
Brugia malayi conserved hypotetical protein 0.0014 0.0018 0.0055
Echinococcus multilocularis leukotriene A 4 hydrolase 0.024 0.1197 0.1197
Brugia malayi Peptidase family M1 containing protein 0.0013 0.0012 0.0036
Onchocerca volvulus 0.0036 0.0132 0.0333
Leishmania major cytochrome p450-like protein 0.0011 0.0001 0.0003
Mycobacterium tuberculosis Probable aldehyde dehydrogenase (NAD+) dependent 0.0014 0.0017 0.0134
Leishmania major hypothetical protein, conserved 0.0023 0.0065 0.0517
Loa Loa (eye worm) hypothetical protein 0.0036 0.0132 0.0403
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0041 0.0157 1
Schistosoma mansoni lipoxygenase 0.002 0.0052 0.0118
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0035 0.0064
Loa Loa (eye worm) hypothetical protein 0.0015 0.0023 0.0068
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0052 0.0419
Loa Loa (eye worm) hypothetical protein 0.003 0.0099 0.0302
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0034 0.0121 0.0968
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.0018 0.0017
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0039 0.0146 0.0145
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0018 0.0017
Loa Loa (eye worm) hypothetical protein 0.0036 0.0132 0.0403
Onchocerca volvulus 0.0082 0.0374 0.1001
Leishmania major cytochrome p450-like protein 0.0011 0.0001 0.0003
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0013 0.0012 0.0011
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0087 0.5175
Schistosoma mansoni axis inhibition protein axin 0.0039 0.0146 0.0336
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0099 0.0099
Treponema pallidum 76K protein 0.0036 0.0132 0.0283
Onchocerca volvulus 0.0015 0.0023 0.003
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0036 0.0132 0.0414
Mycobacterium ulcerans bifunctional acetaldehyde-CoA/alcohol dehydrogenase 0.0014 0.0017 0.0134
Brugia malayi hypothetical protein 0.0027 0.0087 0.0272
Schistosoma mansoni aldehyde dehydrogenase 0.0251 0.1251 0.2886
Loa Loa (eye worm) hypothetical protein 0.0014 0.0018 0.0054
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0146 0.0336
Entamoeba histolytica hypothetical protein 0.0039 0.0148 0.297
Loa Loa (eye worm) hypothetical protein 0.0014 0.0018 0.0054
Loa Loa (eye worm) hypothetical protein 0.0021 0.0052 0.0159
Echinococcus multilocularis Fatty aldehyde dehydrogenase 0.0014 0.0017 0.0017
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0146 0.0336
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0099 0.0099
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0027 0.0026
Entamoeba histolytica hypothetical protein 0.0039 0.0148 0.297
Loa Loa (eye worm) hypothetical protein 0.0053 0.0223 0.0682
Brugia malayi von Willebrand Factor 0.0036 0.0132 0.0414
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0094 0.0228
Onchocerca volvulus 0.0015 0.0023 0.003
Onchocerca volvulus 0.0015 0.0023 0.003
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0099 0.0241
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0146 0.0336
Schistosoma mansoni lamin 0.0082 0.0374 0.0862
Loa Loa (eye worm) hypothetical protein 0.0027 0.0087 0.0265
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0099 0.0302
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.0018 0.0017
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0094 0.0228
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0014 0.0017 0.035
Brugia malayi hypothetical protein 0.0014 0.0018 0.0055
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0013 0.0012 0.0026
Schistosoma mansoni ap endonuclease 0.0041 0.0157 0.0361
Brugia malayi PAN domain containing protein 0.0015 0.0023 0.007
Entamoeba histolytica hypothetical protein 0.0039 0.0148 0.297
Echinococcus granulosus slit 2 protein 0.0023 0.0067 0.0066
Trichomonas vaginalis Phosphoglycerol transferase I, putative 0.0017 0.0035 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0133 0.0335
Echinococcus granulosus axis inhibition protein axin 0.0039 0.0146 0.0145
Brugia malayi PAN domain containing protein 0.0015 0.0023 0.007
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0018 0.0017
Schistosoma mansoni hypothetical protein 0.0266 0.1331 0.3071
Trypanosoma brucei aminopeptidase, putative 0.0013 0.0012 0.0237
Trypanosoma cruzi Aminopeptidase M1, putative 0.0013 0.0012 0.0237
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0014 0.0017 0.0344
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0013 0.0012 0.0011
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0013 0.0012 0.0292
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0099 0.0228
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0099 0.0099
Schistosoma mansoni zinc finger protein 0.0014 0.0018 0.004
Echinococcus multilocularis nuclear receptor nhr 48 0.0014 0.0018 0.0017
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0034 0.0121 0.2443
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0099 0.031
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0099 0.031
Brugia malayi nuclear hormone receptor family member nhr-6 0.0014 0.0018 0.0055
Leishmania major pyrroline-5-carboxylate synthetase-like protein 0.0014 0.0017 0.0137
Leishmania major hypothetical protein, conserved 0.0027 0.0087 0.0694
Brugia malayi aldehyde dehydrogenase 0.0014 0.0017 0.0053
Brugia malayi Intermediate filament tail domain containing protein 0.0082 0.0374 0.1173
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0094 0.229
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0099 0.031
Loa Loa (eye worm) aldehyde dehydrogenase 0.0014 0.0017 0.0051
Loa Loa (eye worm) hypothetical protein 0.0036 0.0132 0.0403
Brugia malayi von Willebrand factor type A domain containing protein 0.0036 0.0132 0.0414
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.0036 0.0132 0.3207
Trypanosoma cruzi cytochrome P450, putative 0.0011 0.0001 0.0007
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0052 0.0419
Brugia malayi hypothetical protein 0.0036 0.0132 0.0414
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0413 0.0951
Brugia malayi hypothetical protein 0.0016 0.0027 0.0082
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.0036 0.0132 0.1058
Echinococcus granulosus geminin 0.0175 0.0859 0.0858
Schistosoma mansoni cpg binding protein 0.0031 0.0109 0.0251
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0052 0.2781
Leishmania major aldehyde dehydrogenase, putative 0.0014 0.0017 0.0137
Mycobacterium tuberculosis Probable aldehyde dehydrogenase NAD dependent AldA (aldehyde dehydrogenase [NAD+]) 0.0014 0.0017 0.0134
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.0497 1
Brugia malayi cytoplasmic intermediate filament protein 0.0044 0.0175 0.0548
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0099 0.0228
Echinococcus multilocularis geminin 0.0175 0.0859 0.0858
Mycobacterium ulcerans aldehyde dehydrogenase 0.0251 0.1251 1
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0052 0.0416
Onchocerca volvulus 0.0036 0.0132 0.0333
Mycobacterium ulcerans NAD-dependent aldehyde dehydrogenase AldA 0.0014 0.0017 0.0134
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase [NADP+] dependent, PutA_2 0.0014 0.0017 0.0134
Schistosoma mansoni ap endonuclease 0.0041 0.0157 0.0361
Echinococcus granulosus aminopeptidase N 0.0013 0.0012 0.0011
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0133 0.0306
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0223 0.0514
Echinococcus multilocularis lamin 0.0082 0.0374 0.0373
Loa Loa (eye worm) hypothetical protein 0.0015 0.0023 0.0068
Schistosoma mansoni aldehyde dehydrogenase 0.0251 0.1251 0.2886
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0087 0.1748
Brugia malayi von Willebrand factor type A domain containing protein 0.0036 0.0132 0.0414
Giardia lamblia Sgs1 DNA helicase, putative 0.0021 0.0052 0.2506
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0146 0.0336
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0133 0.0132
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0023 0.0067 0.0207
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0099 0.0228
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0014 0.0018 0.0017
Echinococcus multilocularis regulator of G protein signaling 3 0.0039 0.0146 0.0145
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0146 0.0336
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0021 0.0052 0.0052
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0094 0.5
Brugia malayi Protein kinase domain containing protein 0.0023 0.0065 0.0202
Loa Loa (eye worm) hypothetical protein 0.0015 0.0023 0.0068
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0065 0.1302
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0099 0.0099
Plasmodium falciparum thrombospondin-related anonymous protein 0.0036 0.0132 0.8295
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0009 0.0008
Brugia malayi hypothetical protein 0.002 0.0052 0.0161
Trichomonas vaginalis succinate semialdehyde dehydrogenase, putative 0.0014 0.0017 0.0015
Toxoplasma gondii NADP-dependent succinate-semialdehyde dehydrogenase 0.0014 0.0017 0.0139
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0011 0.0001 0.0007
Loa Loa (eye worm) hypothetical protein 0.0015 0.0023 0.0068
Schistosoma mansoni nuclear hormone receptor 0.003 0.0099 0.0228
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0036 0.0132 0.0333
Leishmania major cytochrome p450-like protein 0.0011 0.0001 0.0003
Onchocerca volvulus 0.0036 0.0132 0.0333
Entamoeba histolytica hypothetical protein, conserved 0.0036 0.0132 0.2663
Schistosoma mansoni aldehyde dehydrogenase 0.0014 0.0017 0.0039
Brugia malayi orphan nuclear receptor NR2E1 0.0014 0.0018 0.0055
Echinococcus granulosus thyroid hormone receptor alpha 0.0014 0.0018 0.0017
Schistosoma mansoni thyroid hormone receptor 0.0296 0.1484 0.3426
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0106 0.0497 0.1179
Echinococcus granulosus tissue type plasminogen activator 0.0023 0.0065 0.0064
Loa Loa (eye worm) hypothetical protein 0.0016 0.0027 0.008
Schistosoma mansoni cell polarity protein 0.0023 0.0067 0.0152
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0041 0.0157 0.3157
Brugia malayi nuclear receptor NHR-88 0.0014 0.0018 0.0055
Echinococcus granulosus aldehyde dehydrogenase family 3 member B1 0.0014 0.0017 0.0017
Brugia malayi phosphofructokinase 0.0106 0.0497 0.156
Loa Loa (eye worm) hypothetical protein 0.0036 0.0132 0.0403
Echinococcus granulosus RUN 0.002 0.0052 0.0051
Loa Loa (eye worm) hypothetical protein 0.0039 0.0146 0.0446
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0013 0.0012 0.0011
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.0036 0.0132 0.8295
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0014 0.0017 0.0344
Mycobacterium ulcerans aldehyde dehydrogenase 0.0014 0.0017 0.0134
Loa Loa (eye worm) hypothetical protein 0.003 0.0099 0.0302
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.0497 0.134
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0039 0.0146 0.0446
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0018 0.0017
Loa Loa (eye worm) hypothetical protein 0.0036 0.0132 0.0403
Toxoplasma gondii aminopeptidase n, putative 0.0013 0.0012 0.0096
Onchocerca volvulus 0.0015 0.0023 0.003
Echinococcus granulosus cytoplasmic intermediate filament protein 0.004 0.0152 0.0152
Schistosoma mansoni slit 0.0023 0.0067 0.0152
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.001 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0035 0.0064
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0041 0.0157 0.3157
Brugia malayi follicle stimulating hormone receptor 0.023 0.1145 0.3597
Echinococcus granulosus pikachurin 0.0023 0.0067 0.0066
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0121 0.2438
Brugia malayi hypothetical protein 0.0111 0.0521 0.1636
Loa Loa (eye worm) CUTiclin family member 0.0036 0.0132 0.0403
Toxoplasma gondii aminopeptidase N protein 0.0013 0.0012 0.0096
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0148 0.0147
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0094 0.0228
Loa Loa (eye worm) TK/ROR protein kinase 0.0023 0.0065 0.0197
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0014 0.0017 0.0344
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0027 0.006
Brugia malayi laminin-like protein K08C7.3 precursor 0.0023 0.0067 0.0207
Brugia malayi nuclear receptor RXR 0.0014 0.0018 0.0055
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0133 0.0132
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0014 0.0018 0.0017
Toxoplasma gondii aminopeptidase N, putative 0.0013 0.0012 0.0096
Brugia malayi PXA domain containing protein 0.0039 0.0146 0.0457
Giardia lamblia Hypothetical protein 0.0017 0.0035 0.1286
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0094 0.1902
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0041 0.0157 0.1253
Onchocerca volvulus 0.003 0.0099 0.0241
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0099 0.0302
Onchocerca volvulus 0.0015 0.0023 0.003
Schistosoma mansoni nuclear receptor 0.0014 0.0018 0.004
Trichomonas vaginalis set domain proteins, putative 0.0707 0.3628 1
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0013 0.0012 0.0237
Echinococcus multilocularis slit 2 protein 0.0023 0.0067 0.0066
Loa Loa (eye worm) hypothetical protein 0.0038 0.0144 0.0441
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.0036 0.0132 0.0403
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0099 0.031
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0014 0.0017 0.0344
Loa Loa (eye worm) hypothetical protein 0.003 0.0099 0.0302
Loa Loa (eye worm) hypothetical protein 0.0015 0.0023 0.0068
Mycobacterium ulcerans aminopeptidase N PepN 0.0013 0.0012 0.0091
Loa Loa (eye worm) hypothetical protein 0.0017 0.0035 0.0106
Toxoplasma gondii kringle domain-containing protein 0.0023 0.0065 0.0519
Loa Loa (eye worm) hypothetical protein 0.003 0.0099 0.0302
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.0036 0.0132 0.0403
Loa Loa (eye worm) hypothetical protein 0.0039 0.0146 0.0446
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0018 0.0055
Brugia malayi regulator of G-protein signaling egl-10 0.0039 0.0146 0.0457
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0099 0.031
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0126 0.0314
Echinococcus granulosus succinate semialdehyde dehydrogenase 0.0014 0.0017 0.0017
Loa Loa (eye worm) TATA binding protein associated factor 0.0013 0.0012 0.0035
Brugia malayi TATA binding protein associated factor 0.0013 0.0012 0.0036
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0251 0.1251 0.125
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0099 0.0099
Echinococcus multilocularis expressed protein 0.0035 0.0126 0.0125
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0035 0.0064
Toxoplasma gondii PAN/Apple domain-containing protein 0.0015 0.0023 0.0182
Brugia malayi Succinate semialdehyde dehydrogenase, mitochondrial precursor 0.0014 0.0017 0.0053
Mycobacterium leprae PROBABLE SUCCINATE-SEMIALDEHYDE DEHYDROGENASE [NADP+] DEPENDENT (SSDH) GABD 0.0014 0.0017 0.0338
Brugia malayi Immunoglobulin I-set domain containing protein 0.0036 0.0132 0.0414
Loa Loa (eye worm) hypothetical protein 0.0015 0.0023 0.0068
Schistosoma mansoni hypothetical protein 0.0423 0.215 0.4962
Echinococcus multilocularis regulator of G protein signaling 7 0.0039 0.0146 0.0145
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0023 0.0182
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0082 0.0374 0.1144
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0016 0.0029 0.0065
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0035 0.0064
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0023 0.0182
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0041 0.0157 1
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0011 0.0001 0.0003
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0039 0.0146 0.0457
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0052 0.1049

Activities

Activity type Activity value Assay description Source Reference
Log 1/C (binding) = 5.83 Inhibition of [3H]-dopamine uptake in HEK293 cells expressing recombinant Dopamine transporter ChEMBL. 11931612
Log 1/C (binding) = 6.07 Inhibition of [3H]-dopamine uptake in HEK293 cells expressing recombinant Dopamine transporter ChEMBL. 11931612
Log 1/C (binding) = 5.83 Inhibition of [3H]-dopamine uptake in HEK293 cells expressing recombinant Dopamine transporter ChEMBL. 11931612
Log 1/C (binding) = 6.07 Inhibition of [3H]-dopamine uptake in HEK293 cells expressing recombinant Dopamine transporter ChEMBL. 11931612
pKD (binding) = 5.6 Inhibition of [125I]-RTI-55 binding to human SERT in clonal cells ChEMBL. 11931612
pKD (binding) = 6.12 Inhibition of [125I]-RTI-55 binding to human SERT in clonal cells ChEMBL. 11931612
pKD (binding) = 6.72 Inhibition of radioligand [125I]-RTI-55 binding to human Dopamine transporter in clonal cells ChEMBL. 11931612
pKD (binding) = 8 Inhibition of radioligand [125I]-RTI-55 binding to human Dopamine transporter in clonal cells ChEMBL. 11931612
pKD (binding) = 5.6 Inhibition of [125I]-RTI-55 binding to human SERT in clonal cells ChEMBL. 11931612
pKD (binding) = 6.12 Inhibition of [125I]-RTI-55 binding to human SERT in clonal cells ChEMBL. 11931612
pKD (binding) = 6.72 Inhibition of radioligand [125I]-RTI-55 binding to human Dopamine transporter in clonal cells ChEMBL. 11931612
pKD (binding) = 8 Inhibition of radioligand [125I]-RTI-55 binding to human Dopamine transporter in clonal cells ChEMBL. 11931612

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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