Detailed information for compound 597064

Basic information

Technical information
  • TDR Targets ID: 597064
  • Name: N-[4-[1-(4-chlorophenyl)-1-oxopropan-2-yl]oxy phenyl]thiophene-2-carboxamide
  • MW: 385.864 | Formula: C20H16ClNO3S
  • H donors: 1 H acceptors: 2 LogP: 5.18 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)C(=O)C(Oc1ccc(cc1)NC(=O)c1cccs1)C
  • InChi: 1S/C20H16ClNO3S/c1-13(19(23)14-4-6-15(21)7-5-14)25-17-10-8-16(9-11-17)22-20(24)18-3-2-12-26-18/h2-13H,1H3,(H,22,24)
  • InChiKey: KYFSFPKFVYKTCB-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N-[4-[2-(4-chlorophenyl)-1-methyl-2-oxo-ethoxy]phenyl]thiophene-2-carboxamide
  • N-[4-[2-(4-chlorophenyl)-1-methyl-2-oxoethoxy]phenyl]-2-thiophenecarboxamide
  • N-[4-[2-(4-chlorophenyl)-2-keto-1-methyl-ethoxy]phenyl]thiophene-2-carboxamide
  • N-[4-[1-(4-chlorophenyl)-1-oxo-propan-2-yl]oxyphenyl]thiophene-2-carboxamide
  • AK-918/42028986
  • STK258188

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Leishmania mexicana glucose transporter, lmgt2 Starlite/ChEMBL No references
Plasmodium falciparum protein kinase 7 Starlite/ChEMBL No references
Plasmodium falciparum protein kinase 6 Starlite/ChEMBL No references
Homo sapiens solute carrier family 2 (facilitated glucose transporter), member 1 Starlite/ChEMBL No references
Plasmodium falciparum mitogen-activated protein kinase 2 Starlite/ChEMBL No references
Plasmodium falciparum lysine--tRNA ligase Starlite/ChEMBL No references
Plasmodium falciparum hexose transporter Starlite/ChEMBL No references
Plasmodium falciparum (isolate 3D7) Calcium-dependent protein kinase 4 Starlite/ChEMBL No references
Plasmodium falciparum (isolate 3D7) Proline--tRNA ligase Starlite/ChEMBL No references
Plasmodium falciparum calcium-dependent protein kinase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium yoelii Ser/Thr protein kinase Get druggable targets OG5_145294 All targets in OG5_145294
Trypanosoma cruzi hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania donovani lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania infantum lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Babesia bovis lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Echinococcus granulosus calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum ko:K07191 MFS transporter, SP family, solute carrier family 2 (facilitated, putative Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium falciparum calcium-dependent protein kinase 5 Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Cryptosporidium hominis calmodulin-domain protein kinase 1 Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium vivax calcium-dependent protein kinase 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi mitogen-activated protein kinase 2, putative Get druggable targets OG5_138034 All targets in OG5_138034
Brugia malayi lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma japonicum Solute carrier family 2, facilitated glucose transporter member 3, putative Get druggable targets OG5_127135 All targets in OG5_127135
Leishmania mexicana glucose transporter, lmgt3 Get druggable targets OG5_129633 All targets in OG5_129633
Cryptosporidium hominis Kars protein Get druggable targets OG5_126972 All targets in OG5_126972
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania braziliensis glucose transporter, lmgt2 Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type II delta chain, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma cruzi prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Candida albicans lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma mansoni glucose transport protein Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium falciparum proline--tRNA ligase Get druggable targets OG5_127154 All targets in OG5_127154
Toxoplasma gondii protein kinase, putative Get druggable targets OG5_145294 All targets in OG5_145294
Plasmodium knowlesi lysine--tRNA ligase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium berghei lysine--tRNA ligase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Neospora caninum prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Schistosoma mansoni protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania major glucose transporter, lmgt3 Get druggable targets OG5_129633 All targets in OG5_129633
Cryptosporidium parvum calmodulin-domain protein kinase 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma cruzi hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Theileria parva calcium-dependent protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium vivax calcium-dependent protein kinase 4, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium vivax calcium-dependent protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis General substrate transporter Get druggable targets OG5_127135 All targets in OG5_127135
Cryptosporidium parvum calcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium berghei protein kinase 6 Get druggable targets OG5_155179 All targets in OG5_155179
Neospora caninum CMGC kinase, MAPK family, putative Get druggable targets OG5_138034 All targets in OG5_138034
Plasmodium berghei calcium-dependent protein kinase 5 Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania donovani glucose transporter 3, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trichomonas vaginalis glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Candida albicans C terminus is almost identical to CaP19.2865 Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium falciparum calcium-dependent protein kinase 1 Get druggable targets OG5_126600 All targets in OG5_126600
Babesia bovis calcium-dependent protein kinase 4 Get druggable targets OG5_126600 All targets in OG5_126600
Theileria parva prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania infantum prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Echinococcus granulosus solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Echinococcus multilocularis solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma brucei gambiense hexose transporter,glucose transporter 1B Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium berghei mitogen-activated protein kinase 2 Get druggable targets OG5_138034 All targets in OG5_138034
Plasmodium yoelii Plasmodium falciparum CDPK2 protein Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania donovani protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Candida albicans almost identical to C terminus of CaP19.2425 Get druggable targets OG5_127135 All targets in OG5_127135
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type II beta chain, putative Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis calcium dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei THT1 - hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania infantum glucose transporter/membrane transporter D2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania major glucose transporter, lmgt1 Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania donovani glucose transporter/membrane transporter D2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium vivax CDK-related protein kinase 6, putative Get druggable targets OG5_155179 All targets in OG5_155179
Plasmodium falciparum protein kinase 7 Get druggable targets OG5_145294 All targets in OG5_145294
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain Get druggable targets OG5_126600 All targets in OG5_126600
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma mansoni protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi calcium-dependent protein kinase 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium vivax calcium-dependent protein kinase 3, putative Get druggable targets OG5_126600 All targets in OG5_126600
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative Get druggable targets OG5_138034 All targets in OG5_138034
Trichomonas vaginalis glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127154 All targets in OG5_127154
Neospora caninum hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma cruzi hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Theileria parva mitogen-activated protein kinase 2, putative Get druggable targets OG5_138034 All targets in OG5_138034
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma congolense glucose transporter 2A, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Brugia malayi Cam kinase protein 1 Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Cryptosporidium hominis CDPK2 Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Babesia bovis mitogen-activated protein kinase, putative Get druggable targets OG5_138034 All targets in OG5_138034
Plasmodium yoelii mitogen-activated protein kinase 2 Get druggable targets OG5_138034 All targets in OG5_138034
Toxoplasma gondii calcium-dependent protein kinase CDPK3 Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium hominis calcium-dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Theileria parva serine/threonine protein kinase, putative Get druggable targets OG5_145294 All targets in OG5_145294
Candida albicans almost identical to C terminus of CaP19.2425 Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei THT1 - hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma mansoni lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium yoelii calcium-dependent protein kinase-3 Get druggable targets OG5_126600 All targets in OG5_126600
Trichomonas vaginalis prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania braziliensis prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Neospora caninum hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania major glucose transporter, lmgt2 Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium falciparum calcium-dependent protein kinase 3 Get druggable targets OG5_126600 All targets in OG5_126600
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127135 All targets in OG5_127135
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) Get druggable targets OG5_127154 All targets in OG5_127154
Schistosoma japonicum ko:K04567 lysyl-tRNA synthetase, class II, putative Get druggable targets OG5_126972 All targets in OG5_126972
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum ko:K04515 calcium/calmodulin-dependent protein kinase (CaM kinase) II, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum calcium-dependent protein kinase 2 Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium yoelii cdk-related protein kinase 6-related Get druggable targets OG5_155179 All targets in OG5_155179
Echinococcus granulosus General substrate transporter Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium berghei protein kinase 7 Get druggable targets OG5_145294 All targets in OG5_145294
Cryptosporidium hominis aminoacyl-tRNA synthetase Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania major protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum Solute carrier family 2, facilitated glucose transporter member 4, putative Get druggable targets OG5_127135 All targets in OG5_127135
Toxoplasma gondii calcium-dependent protein kinase CDPK2A Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium hominis mitogen-activated protein kinase 2 Get druggable targets OG5_138034 All targets in OG5_138034
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium vivax mitogen-activated protein kinase 2, putative Get druggable targets OG5_138034 All targets in OG5_138034
Leishmania infantum glucose transporter, lmgt2 Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type II alpha chain, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium yoelii putative sugar transporter Get druggable targets OG5_127135 All targets in OG5_127135
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania major lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Toxoplasma gondii lysine-tRNA ligase Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania mexicana glucose transporter/membrane transporter D2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium falciparum mitogen-activated protein kinase 2 Get druggable targets OG5_138034 All targets in OG5_138034
Candida albicans hypothetical protein Get druggable targets OG5_127154 All targets in OG5_127154
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania braziliensis lmgt2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trichomonas vaginalis lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium berghei calcium-dependent protein kinase 4 Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania mexicana protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi hexose transporter, putative Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma brucei gambiense hexose transporter,glucose transporter 1B, putative Get druggable targets OG5_129633 All targets in OG5_129633
Candida albicans lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania braziliensis glucose transporter/membrane transporter D2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Giardia lamblia Lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium knowlesi calcium-dependent protein kinase 4, putative Get druggable targets OG5_126600 All targets in OG5_126600
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania donovani glucose transporter 1 Get druggable targets OG5_129633 All targets in OG5_129633
Neospora caninum protein kinase, PfPK7 homolog, putative Get druggable targets OG5_145294 All targets in OG5_145294
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium knowlesi proline--tRNA ligase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma congolense glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium parvum proline-tRNA synthetase; class II aaRS (ybak RNA binding domain plus tRNA synthetase) Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma congolense lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Brugia malayi bifunctional aminoacyl-tRNA synthetase Get druggable targets OG5_127154 All targets in OG5_127154
Candida albicans Serine-threonine protein kinase similar to S. cerevisiae CMK2 (YOL016C) calcium/calmodulin-dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Giardia lamblia Prolyl-tRNA synthetase Get druggable targets OG5_127154 All targets in OG5_127154
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) Get druggable targets OG5_127154 All targets in OG5_127154
Schistosoma mansoni glucose transport protein Get druggable targets OG5_127135 All targets in OG5_127135
Echinococcus granulosus lysyl tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Echinococcus multilocularis lysyl tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic Get druggable targets OG5_127154 All targets in OG5_127154
Brugia malayi Sugar transporter family protein Get druggable targets OG5_127135 All targets in OG5_127135
Babesia bovis prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma brucei gambiense glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126972 All targets in OG5_126972
Candida albicans Serine-threonine protein kinase similar to S. cerevisiae CMK2 (YOL016C) calcium/calmodulin-dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum Solute carrier family 2, facilitated glucose transporter member 1, putative Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium parvum calcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum hexose transporter Get druggable targets OG5_127135 All targets in OG5_127135
Toxoplasma gondii calcium-dependent protein kinase CDPK2B Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium parvum lysyl-tRNA synthetase (NOB+tRNA synthetase) Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma japonicum ko:K08794 calcium/calmodulin-dependent protein kinase I, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium falciparum protein kinase 6 Get druggable targets OG5_155179 All targets in OG5_155179
Chlamydia trachomatis lysine--tRNA ligase Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania major glucose transporter/membrane transporter D2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania mexicana glucose transporter, lmgt1 Get druggable targets OG5_129633 All targets in OG5_129633
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania mexicana glucose transporter, lmgt2 Get druggable targets OG5_129633 All targets in OG5_129633
Cryptosporidium parvum calcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands Get druggable targets OG5_126600 All targets in OG5_126600
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania mexicana lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania infantum glucose transporter, lmgt3 Get druggable targets OG5_129633 All targets in OG5_129633
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX Get druggable targets OG5_126972 All targets in OG5_126972
Trypanosoma brucei THT1 - hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium yoelii calcium-dept. protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania mexicana prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Echinococcus granulosus calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Brugia malayi Bifunctional aminoacyl-tRNA synthetase Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma congolense glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Candida albicans similar to S. cerevisiae YHR020W Get druggable targets OG5_127154 All targets in OG5_127154
Candida albicans C terminus is almost identical to CaP19.2865 Get druggable targets OG5_127135 All targets in OG5_127135
Mycobacterium ulcerans lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi calcium-dependent protein kinase 5, putative Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum Calcium-dependent protein kinase 2, related Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma japonicum IPR000924,Glutamyl-tRNA synthetase, class Ic;IPR001412,Aminoacyl-tRNA synthetase, class I,domain-containing Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma cruzi lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Theileria parva calmodulin-domain protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trichomonas vaginalis sugar transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania infantum prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium knowlesi calcium-dependent protein kinase 3, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium berghei hexose transporter Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma congolense prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium vivax lysine--tRNA ligase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium vivax hexose transporter Get druggable targets OG5_127135 All targets in OG5_127135
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Echinococcus multilocularis solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Mycobacterium leprae Probable prolyl tRNA synthetase ProS Get druggable targets OG5_127154 All targets in OG5_127154
Echinococcus multilocularis solute carrier family 2, facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Schistosoma japonicum ko:K01881 prolyl-tRNA synthetase [EC6.1.1.15], putative Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma brucei lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium yoelii lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Theileria parva lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium yoelii prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium berghei calcium-dependent protein kinase 1 Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei gambiense prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma brucei gambiense glucose transporter,glucose transporter 2A, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma brucei gambiense glucose transporter Get druggable targets OG5_129633 All targets in OG5_129633
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum Glucose transporter 1A, related Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma cruzi hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Cryptosporidium parvum mitogen-activated protein kinase 2, putative Get druggable targets OG5_138034 All targets in OG5_138034
Trichomonas vaginalis sugar transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma cruzi prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Schistosoma japonicum expressed protein Get druggable targets OG5_127154 All targets in OG5_127154
Schistosoma mansoni lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Echinococcus granulosus calcium dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum Calmodulin-like domain protein kinase isoenzyme gamma, related Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei glucose transporter 1E Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Mycobacterium ulcerans lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma mansoni protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania braziliensis lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma mansoni glucose transport protein Get druggable targets OG5_127135 All targets in OG5_127135
Trichomonas vaginalis sugar transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium falciparum lysine--tRNA ligase Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium knowlesi CDK-related protein kinase 6, putative Get druggable targets OG5_155179 All targets in OG5_155179
Schistosoma japonicum ko:K07299 MFS transporter, SP family, solute carrier family 2 (facilitated, putative Get druggable targets OG5_127135 All targets in OG5_127135
Candida albicans similar to S. cerevisiae YHR020W Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania infantum protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania infantum glucose transporter, lmgt1 Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium vivax proline--tRNA ligase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma brucei glucose transporter 2A Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium knowlesi protein kinase 7, putative Get druggable targets OG5_145294 All targets in OG5_145294
Entamoeba histolytica prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium yoelii calmodulin-domain protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma mansoni hypothetical protein Get druggable targets OG5_127135 All targets in OG5_127135
Toxoplasma gondii facilitative glucose transporter GT1 Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma cruzi hexose transporter Get druggable targets OG5_129633 All targets in OG5_129633
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium berghei proline--tRNA ligase Get druggable targets OG5_127154 All targets in OG5_127154
Neospora caninum lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium berghei calcium-dependent protein kinase 3 Get druggable targets OG5_126600 All targets in OG5_126600
Trichomonas vaginalis lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Loa Loa (eye worm) sugar transporter Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma brucei gambiense lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium falciparum calcium-dependent protein kinase 4 Get druggable targets OG5_126600 All targets in OG5_126600
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma japonicum IPR005828,General substrate transporter,domain-containing Get druggable targets OG5_127135 All targets in OG5_127135
Leishmania mexicana prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Loa Loa (eye worm) CAMK/CAMK2 protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative Calcium-dependent protein kinase 4   528 aa 489 aa 28.8 %
Trypanosoma brucei glucose transporter, putative hexose transporter 504 aa 426 aa 22.3 %
Leishmania donovani protein kinase, putative Calcium-dependent protein kinase 4   528 aa 486 aa 27.4 %
Trypanosoma brucei protein kinase, putative Calcium-dependent protein kinase 4   528 aa 524 aa 26.7 %
Trypanosoma brucei gambiense protein kinase, putative Calcium-dependent protein kinase 4   528 aa 524 aa 26.7 %
Neospora caninum CAM kinase, CDPK family, putative Calcium-dependent protein kinase 4   528 aa 463 aa 32.0 %
Trypanosoma congolense protein kinase, putative Calcium-dependent protein kinase 4   528 aa 499 aa 29.3 %
Trypanosoma brucei mitogen-activated protein kinase 5 protein kinase 6 305 aa 338 aa 27.2 %
Entamoeba histolytica protein kinase, putative Calcium-dependent protein kinase 4   528 aa 429 aa 26.3 %
Cryptosporidium parvum hypothetical protein Calcium-dependent protein kinase 4   528 aa 463 aa 34.1 %
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative Calcium-dependent protein kinase 4   528 aa 527 aa 25.6 %
Leishmania mexicana protein kinase, putative Calcium-dependent protein kinase 4   528 aa 486 aa 27.2 %
Leishmania infantum protein kinase, putative Calcium-dependent protein kinase 4   528 aa 486 aa 27.4 %
Toxoplasma gondii calcium-dependent protein kinase CDPK6 Calcium-dependent protein kinase 4   528 aa 453 aa 34.0 %
Toxoplasma gondii calcium-dependent protein kinase CDPK9 Calcium-dependent protein kinase 4   528 aa 500 aa 34.2 %
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative Calcium-dependent protein kinase 4   528 aa 489 aa 29.0 %
Cryptosporidium hominis calmodulin-domain protein kinase 2 Calcium-dependent protein kinase 4   528 aa 468 aa 36.1 %
Leishmania braziliensis protein kinase, putative Calcium-dependent protein kinase 4   528 aa 490 aa 27.3 %
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative Calcium-dependent protein kinase 4   528 aa 522 aa 25.5 %
Neospora caninum Calcium-dependent protein kinase, related Calcium-dependent protein kinase 4   528 aa 516 aa 35.5 %
Cryptosporidium parvum calcium/calmodulin-dependent protein kinase with a kinase domain and 4 calmodulin like EF hands Calcium-dependent protein kinase 4   528 aa 468 aa 35.9 %
Trypanosoma brucei protein lipid droplet kinase (LDK) protein kinase 7 343 aa 310 aa 25.2 %
Cryptosporidium hominis hypothetical protein Calcium-dependent protein kinase 4   528 aa 463 aa 34.1 %
Babesia bovis mitogen-activated protein kinase, putative Calcium-dependent protein kinase 4   528 aa 427 aa 23.4 %
Giardia lamblia Kinase, NEK Calcium-dependent protein kinase 4   528 aa 509 aa 19.8 %
Trypanosoma brucei glucose transporter, putative solute carrier family 2 (facilitated glucose transporter), member 1 492 aa 395 aa 23.5 %
Theileria parva calmodulin-domain protein kinase, putative Calcium-dependent protein kinase 4   528 aa 454 aa 31.9 %
Toxoplasma gondii calcium-dependent protein kinase CDPK2 Calcium-dependent protein kinase 4   528 aa 480 aa 36.9 %
Trypanosoma congolense protein kinase, putative Calcium-dependent protein kinase 4   528 aa 517 aa 27.9 %
Babesia bovis calcium-dependent protein kinase, putative Calcium-dependent protein kinase 4   528 aa 450 aa 30.2 %
Trypanosoma congolense protein kinase, putative Calcium-dependent protein kinase 4   528 aa 509 aa 25.5 %
Theileria parva protein kinase, putative Calcium-dependent protein kinase 4   528 aa 507 aa 27.4 %
Cryptosporidium parvum calcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands Calcium-dependent protein kinase 4   528 aa 501 aa 28.9 %
Leishmania major protein kinase, putative Calcium-dependent protein kinase 4   528 aa 488 aa 27.5 %
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative Calcium-dependent protein kinase 4   528 aa 524 aa 26.7 %
Cryptosporidium hominis calcium-dependent protein kinase Calcium-dependent protein kinase 4   528 aa 502 aa 29.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0018 0.0157 0.0392
Echinococcus multilocularis son of sevenless 1 0.0007 0.0015 0.0001
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.002 0.0007
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0014 0.0106 0.0265
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0169 0.0422
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0126 0.1536 0.1525
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0095 0.0222
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0007 0.0021 0.0041
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0014 0.0106 0.0265
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0038 0.0413 0.0437
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0956
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0039 0.0423 0.0627
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0302 0.3766 0.9408
Plasmodium falciparum calcium-dependent protein kinase 4 0.0039 0.0423 0.0621
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0048 0.0038
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0956
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0014 0.0106 0.0116
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0168 0.042
Brugia malayi N-terminal motif family protein 0.0007 0.0015 0.0036
Trypanosoma cruzi hypothetical protein 0.0007 0.0015 0.0036
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.014 0.02
Echinococcus granulosus solute carrier family 22 0.0018 0.0157 0.0157
Brugia malayi TAR-binding protein 0.0065 0.0754 0.1884
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0056 0.0141
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0056 0.0183
Leishmania major hypothetical protein, conserved 0.0006 0.0011 0.0015
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0008 0.0038 0.0084
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0018 0.0157 0.0697
Schistosoma mansoni hypothetical protein 0.0401 0.5027 0.549
Onchocerca volvulus 0.0014 0.0106 0.0398
Echinococcus granulosus dna polymerase kappa 0.0019 0.0168 0.017
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0006 0.0013 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0056 0.0141
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0014 0.0106 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0429 0.274
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0399 0.0972
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0007 0.0021 0.0053
Echinococcus granulosus solute carrier family 22 0.0018 0.0157 0.0157
Chlamydia trachomatis proline--tRNA ligase 0.0013 0.0101 0.2978
Echinococcus granulosus geminin 0.0516 0.6489 0.7083
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0429 0.1057
Onchocerca volvulus 0.0018 0.0157 0.0619
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0169 0.1036
Leishmania major DNA polymerase kappa, putative 0.0019 0.0168 0.0403
Entamoeba histolytica hypothetical protein 0.0023 0.0222 0.256
Entamoeba histolytica cysteine proteinase 1, putative 0.0008 0.0038 0.0295
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0012 0.0008
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.002 0.0007
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0056 0.0043
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0168 0.0403
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0039 0.0423 0.0448
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.014 0.0138
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0046 0.052 0.0554
Loa Loa (eye worm) hypothetical protein 0.0011 0.0071 0.0177
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0289 0.0722
Echinococcus multilocularis glycyl tRNA synthetase 0.0007 0.0021 0.0008
Trypanosoma cruzi sugar transporter, putative 0.0018 0.0157 0.0386
Schistosoma mansoni cpg binding protein 0.0028 0.0289 0.0315
Entamoeba histolytica hypothetical protein 0.0028 0.0289 0.3385
Brugia malayi steroid hormone receptor 0.001 0.0056 0.0141
Plasmodium falciparum proline--tRNA ligase 0.0044 0.0492 0.0724
Plasmodium vivax vivapain-1 0.0008 0.0038 0.0057
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0168 0.0403
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0126 0.1536 0.1525
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0168 0.1893
Loa Loa (eye worm) hypothetical protein 0.0038 0.0413 0.1031
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.014 0.0845
Schistosoma mansoni hypothetical protein 0.007 0.0826 0.0902
Brugia malayi Cathepsin L-like precursor 0.0016 0.014 0.0349
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0056 0.0141
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.09 0.2219
Brugia malayi hypothetical protein 0.0009 0.0048 0.012
Leishmania major hypothetical protein, conserved 0.0076 0.09 0.221
Echinococcus granulosus tar DNA binding protein 0.0065 0.0754 0.0811
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0014 0.0106 0.0093
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0168 0.0403
Trichomonas vaginalis guanine nucleotide exchange factor, putative 0.0007 0.0015 0.0024
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.014 0.0152
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0956
Onchocerca volvulus Cathepsin F homolog 0.0016 0.014 0.0545
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0014 0.0106 0.0265
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.014 0.0138
Entamoeba histolytica cysteine proteinase, putative 0.0008 0.0038 0.0295
Loa Loa (eye worm) AGC/PKG protein kinase 0.0006 0.0013 0.0033
Schistosoma mansoni survival motor neuron protein 0.0047 0.0532 0.0581
Loa Loa (eye worm) hypothetical protein 0.001 0.0056 0.0141
Echinococcus granulosus snurportin 1 0.0302 0.3766 0.4104
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0038 0.0413 0.0451
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0956
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.09 0.2219
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0056 0.0043
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.007 0.0826 0.0889
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0423 0.0461
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.032 0.4003 0.3995
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.014 0.0845
Plasmodium falciparum threonine--tRNA ligase 0.0007 0.0021 0.0025
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0399 0.0386
Toxoplasma gondii glycyl-tRNA synthetase 0.0007 0.0021 0.0037
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0726 0.1779
Entamoeba histolytica protein kinase, putative 0.0039 0.0423 0.5026
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0195 0.4677
Schistosoma mansoni GTP-binding protein alpha subunit 0.0014 0.0106 0.0116
Onchocerca volvulus 0.0018 0.0157 0.0619
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0168 0.1031
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0195 0.0488
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0012 0.0008
Schistosoma mansoni serine/threonine protein kinase 0.0006 0.0013 0.0014
Leishmania major cathepsin L-like protease 0.0016 0.014 0.0333
Brugia malayi Papain family cysteine protease containing protein 0.0008 0.0038 0.0096
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0048 0.012
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.014 0.1712 0.1869
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0056 0.0141
Echinococcus granulosus cpg binding protein 0.003 0.0309 0.0324
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0014 0.0106 0.0265
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0056 0.0141
Schistosoma mansoni hypothetical protein 0.0034 0.0366 0.04
Toxoplasma gondii sugar transporter ST2 0.0018 0.0157 0.0341
Trichomonas vaginalis conserved hypothetical protein 0.0126 0.1536 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0012 0.0008
Echinococcus multilocularis solute carrier family 22 0.0018 0.0157 0.0144
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0056 0.0043
Giardia lamblia Sugar-proton symporter 0.0018 0.0157 0.3728
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0726 0.1789
Echinococcus multilocularis solute carrier family 22 0.0018 0.0157 0.0144
Entamoeba histolytica protein kinase, putative 0.0039 0.0423 0.5026
Brugia malayi hypothetical protein 0.0018 0.0157 0.0392
Trypanosoma brucei unspecified product 0.0019 0.0168 0.0403
Schistosoma mansoni cpg binding protein 0.003 0.0309 0.0338
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0168 0.0403
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.007 0.0826 0.0814
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0014 0.0106 0.0093
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0726 0.1779
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0039 0.0423 0.1031
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0048 0.0035
Trypanosoma cruzi hypothetical protein, conserved 0.0006 0.0011 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0012 0.0008
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0169 0.0422
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0007 0.0021 0.0053
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0056 0.0141
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.032 0.4003 0.4372
Echinococcus granulosus GPCR family 2 0.0046 0.052 0.0554
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0726 0.1789
Entamoeba histolytica cysteine protease, putative 0.0008 0.0038 0.0295
Echinococcus granulosus dna polymerase eta 0.0019 0.0168 0.017
Loa Loa (eye worm) ctsf protein 0.0016 0.014 0.0349
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.014 0.0845
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0056 0.0141
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0014 0.0106 0.0116
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0046 0.0511 0.126
Loa Loa (eye worm) hypothetical protein 0.0018 0.0157 0.0392
Brugia malayi hypothetical protein 0.0018 0.0157 0.0392
Trichomonas vaginalis glucose transporter, putative 0.0039 0.0429 0.274
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.014 0.0127
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0007 0.0021 0.0053
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.032 0.4003 0.4372
Trypanosoma cruzi cysteine proteinase, putative 0.0008 0.0038 0.0095
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0028 0.0289 0.1355
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0046 0.0511 0.125
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0956
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0399 0.4734
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.0007 0.0015 0.0001
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0014 0.0106 0.0116
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0056 0.0062
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0056 0.0141
Echinococcus multilocularis snurportin 1 0.0302 0.3766 0.3758
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.1536 0.1666
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0014 0.0106 0.0102
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0048 0.0035
Loa Loa (eye worm) RasGEF domain-containing protein 0.0007 0.0015 0.0036
Schistosoma mansoni microtubule-associated protein tau 0.0725 0.9157 1
Plasmodium vivax glycine--tRNA ligase, putative 0.0007 0.0021 0.0032
Trichomonas vaginalis CAMK family protein kinase 0.0039 0.0423 0.2699
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0157 0.0956
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0411 0.0603
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0014 0.0106 0.0265
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0956
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.014 0.0845
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0187 0.231 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0071 0.0392
Loa Loa (eye worm) hypothetical protein 0.0018 0.0157 0.0392
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0008 0.0038 0.0181
Loa Loa (eye worm) hypothetical protein 0.0014 0.0106 0.0265
Leishmania major cathepsin L-like protease 0.0016 0.014 0.0333
Brugia malayi major facilitator superfamily protein 0.0018 0.0157 0.0392
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0039 0.0423 0.041
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0404 0.0986
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0056 0.0183
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0014 0.0106 0.0116
Trypanosoma cruzi hexose transporter, putative 0.0021 0.0203 0.0501
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0056 0.0141
Loa Loa (eye worm) hypothetical protein 0.0011 0.0071 0.0177
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0018 0.0157 0.0226
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0014 0.0106 0.0116
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.014 0.02
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.002 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0056 0.0141
Schistosoma mansoni glucose transporter 0.0018 0.0157 0.0171
Plasmodium vivax importin-beta 2, putative 0.0028 0.029 0.043
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0007 0.0021 0.0053
Loa Loa (eye worm) hypothetical protein 0.0187 0.231 0.5772
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.09 0.1329
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0222 0.1387
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.014 0.0845
Entamoeba histolytica cysteine protease, putative 0.0016 0.014 0.1541
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0012 0.0008
Loa Loa (eye worm) hypothetical protein 0.0018 0.0157 0.0392
Mycobacterium ulcerans sugar transporter 0.0018 0.0157 0.0724
Loa Loa (eye worm) fibroinase 0.0016 0.014 0.0349
Leishmania major glucose transporter, lmgt3 0.0039 0.0429 0.1047
Onchocerca volvulus 0.0016 0.014 0.0545
Onchocerca volvulus 0.0016 0.014 0.0545
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0024 0.0235 0.5587
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.0511 0.126
Leishmania major threonyl-tRNA synthetase, putative 0.0007 0.0021 0.0041
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0399 0.2543
Loa Loa (eye worm) hypothetical protein 0.0007 0.0021 0.0053
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0324 0.4058 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0056 0.0638 0.1573
Brugia malayi RasGEF domain containing protein 0.0007 0.0015 0.0036
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0056 0.0141
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0956
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0355 0.8563
Plasmodium falciparum mitogen-activated protein kinase 2 0.0204 0.2525 0.374
Mycobacterium ulcerans integral membrane transport protein 0.0018 0.0157 0.0724
Plasmodium falciparum lysine--tRNA ligase 0.0028 0.0289 0.0422
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0012 0.0008
Trichomonas vaginalis ras GTP exchange factor, putative 0.0007 0.0015 0.0024
Loa Loa (eye worm) hypothetical protein 0.0009 0.0048 0.012
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0726 0.1779
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0168 0.0403
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0056 0.0141
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0399 0.0422
Loa Loa (eye worm) hypothetical protein 0.001 0.0056 0.0141
Brugia malayi major facilitator superfamily protein 0.0018 0.0157 0.0392
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0056 0.0183
Brugia malayi Cathepsin L-like precursor 0.0016 0.014 0.0349
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0169 0.025
Brugia malayi hypothetical protein 0.007 0.0826 0.2064
Schistosoma mansoni thyroid hormone receptor 0.001 0.0056 0.0062
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0009 0.0048 0.0146
Toxoplasma gondii sugar transporter ST1 0.0018 0.0157 0.0341
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0048 0.012
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0039 0.0423 0.0627
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0038 0.0413 0.0451
Mycobacterium ulcerans hypothetical protein 0.0171 0.2105 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0039 0.0423 0.0937
Echinococcus multilocularis lysyl tRNA synthetase 0.0028 0.0289 0.0277
Loa Loa (eye worm) hypothetical protein 0.0038 0.0413 0.1031
Brugia malayi Sugar transporter family protein 0.0126 0.1536 0.3837
Leishmania major cathepsin L-like protease 0.0062 0.0726 0.1779
Brugia malayi nuclear hormone receptor 0.001 0.0056 0.0141
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0071 0.0392
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0056 0.0047
Plasmodium falciparum importin beta, putative 0.0028 0.029 0.0424
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0726 0.1779
Echinococcus granulosus Threonyl tRNA synthetase C 0.0007 0.0021 0.0009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0726 0.1779
Loa Loa (eye worm) hypothetical protein 0.0018 0.0157 0.0392
Loa Loa (eye worm) RasGEF domain-containing protein 0.0007 0.0015 0.0036
Schistosoma mansoni lysyl-tRNA synthetase 0.0028 0.0289 0.0316
Onchocerca volvulus 0.0018 0.0157 0.0619
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0006 0.0011 0.0027
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.2877 0.2868
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.014 0.0127
Echinococcus granulosus cathepsin L 0.0008 0.0038 0.0028
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0956
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0056 0.0062
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0404 0.1904
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0014 0.0106 0.0265
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0015 0.0016
Plasmodium falciparum cysteine proteinase falcipain 1 0.0008 0.0038 0.005
Echinococcus multilocularis Protein son of sevenless 0.0007 0.0015 0.0001
Trypanosoma brucei glucose transporter, putative 0.0039 0.0429 0.1047
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0038 0.0413 0.1031
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0126 0.1536 0.1525
Onchocerca volvulus 0.0018 0.0157 0.0619
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0014 0.0106 0.0102
Echinococcus granulosus ras GTP exchange factor 0.0007 0.0015 0.0002
Trypanosoma cruzi cysteine protease, putative 0.0008 0.0038 0.0095
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0056 0.0062
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0399 0.0435
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0013 0.0101 0.0459
Loa Loa (eye worm) acetyltransferase 0.014 0.1712 0.4276
Trypanosoma brucei glucose transporter, putative 0.0039 0.0429 0.1047
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0399 0.9661
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0018 0.0157 0.0375
Brugia malayi hypothetical protein 0.0014 0.0106 0.0265
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0018 0.0157 0.3534
Loa Loa (eye worm) hypothetical protein 0.0018 0.0157 0.0392
Loa Loa (eye worm) hypothetical protein 0.0076 0.09 0.225
Leishmania major glucose transporter/membrane transporter D2, putative 0.0039 0.0429 0.1047
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0024 0.0235 0.1072
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0044 0.0492 0.1203
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0044 0.0492 0.1213
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0399 0.2543
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0048 0.0053
Loa Loa (eye worm) sugar transporter 0.0018 0.0157 0.0392
Schistosoma mansoni thyroid hormone receptor 0.001 0.0056 0.0062
Brugia malayi acetyltransferase, GNAT family protein 0.014 0.1712 0.4276
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0007 0.0021 0.0053
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0014 0.0106 0.0624
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0168 0.0414
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.032 0.4003 0.3995
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0007 0.0021 0.0262
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0168 0.0184
Trichomonas vaginalis glucose transporter, putative 0.0018 0.0157 0.0956
Onchocerca volvulus 0.0016 0.014 0.0545
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0048 0.0035
Entamoeba histolytica glycyl-tRNA synthetase, putative 0.0007 0.0021 0.0084
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0355 0.1643
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0056 0.0043
Onchocerca volvulus 0.0018 0.0157 0.0619
Brugia malayi RNA binding protein 0.0065 0.0754 0.1884
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0056 0.0043
Trypanosoma brucei glucose transporter, putative 0.0039 0.0429 0.1047
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0956
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0168 0.0414
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0018 0.0157 0.0171
Onchocerca volvulus Cathepsin L homolog 0.0016 0.014 0.0545
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0007 0.0021 0.0041
Loa Loa (eye worm) hypothetical protein 0.0014 0.0106 0.0265
Brugia malayi RasGEF domain containing protein 0.0007 0.0015 0.0036
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0056 0.0062
Entamoeba histolytica cysteine proteinase, putative 0.0008 0.0038 0.0295
Trichomonas vaginalis helicase, putative 0.0006 0.0012 0.0008
Loa Loa (eye worm) hypothetical protein 0.001 0.0056 0.0141
Leishmania major glucose transporter, lmgt1 0.0039 0.0429 0.1047
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0056 0.0062
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0404 1
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0048 0.012
Plasmodium vivax vivapain-2 0.0016 0.014 0.0207
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0157 0.0956
Schistosoma mansoni importin beta-1 0.0028 0.029 0.0317
Echinococcus granulosus importin subunit beta 1 0.0028 0.029 0.0303
Leishmania major cysteine peptidase A (CPA) 0.0016 0.014 0.0333
Onchocerca volvulus 0.0009 0.0048 0.0146
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0455 0.1009
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0404 0.0986
Brugia malayi Importin beta-1 subunit 0.0028 0.029 0.0725
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0046 0.052 0.0508
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0399 0.0996
Schistosoma mansoni hypothetical protein 0.0126 0.1536 0.1678
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0399 0.0983
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0754 0.0824
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0039 0.0423 0.0448
Onchocerca volvulus 0.0016 0.014 0.0545
Brugia malayi RasGEF domain containing protein 0.0007 0.0015 0.0036
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0956
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0157 0.0386
Trypanosoma brucei glucose transporter, putative 0.0039 0.0429 0.1047
Loa Loa (eye worm) hypothetical protein 0.0018 0.0157 0.0392
Schistosoma mansoni protein kinase 0.0039 0.0423 0.0461
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0956
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0056 0.0043
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0028 0.0289 0.1826
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0169 0.0416
Entamoeba histolytica cysteine protease, putative 0.0008 0.0038 0.0295
Entamoeba histolytica cysteine protease, putative 0.0008 0.0038 0.0295
Schistosoma mansoni dishevelled 0.0009 0.0048 0.0053
Leishmania major mitochondrial DNA polymerase beta 0.0324 0.4058 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0157 0.0392
Plasmodium vivax ataxin-2 like protein, putative 0.0076 0.09 0.1335
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0095 0.0222
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.014 0.0845
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0044 0.0492 0.1203
Loa Loa (eye worm) hypothetical protein 0.001 0.0056 0.0141
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0754 0.1884
Loa Loa (eye worm) hypothetical protein 0.0018 0.0157 0.0392
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.1536 0.1666
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0014 0.0106 0.0116
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0014 0.0106 0.0102
Onchocerca volvulus Cathepsin L homolog 0.0016 0.014 0.0545
Schistosoma mansoni GTP-binding protein alpha subunit 0.0014 0.0106 0.0116
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0532 0.1329
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0048 0.0053
Brugia malayi CXXC zinc finger family protein 0.0028 0.0289 0.0722
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.0007 0.0015 0.0002
Brugia malayi Sugar transporter family protein 0.0018 0.0157 0.0392
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0018 0.0157 0.0724
Schistosoma mansoni DNA polymerase IV / kappa 0.0006 0.0005 0.0005
Leishmania major protein kinase, putative 0.0006 0.0013 0.0021
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0039 0.0423 0.041
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0056 0.0047
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0399 0.0972
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0204 0.2525 0.5649
Echinococcus granulosus cathepsin l1 0.0011 0.0071 0.0063
Schistosoma mansoni inositol monophosphatase 0.0037 0.0404 0.0442
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0195 0.0471
Giardia lamblia Glycyl-tRNA synthetase 0.0007 0.0021 0.041
Echinococcus granulosus histone acetyltransferase KAT2B 0.0136 0.1662 0.1803
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0154 0.1884 0.4637
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0018 0.0157 0.0724
Schistosoma mansoni hypothetical protein 0.0516 0.6489 0.7087
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0056 0.0047
Echinococcus multilocularis microtubule associated protein 2 0.0725 0.9157 0.9156
Loa Loa (eye worm) hypothetical protein 0.0146 0.1792 0.4478
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0039 0.0423 0.041
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0024 0.0235 0.1072
Echinococcus multilocularis cathepsin L 0.0008 0.0038 0.0025
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.002 0.0007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0056 0.0141
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0012 0.0008
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.014 0.0845
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0168 0.0403
Onchocerca volvulus 0.0018 0.0157 0.0619
Schistosoma mansoni glucose transport protein 0.0126 0.1536 0.1678
Trypanosoma brucei unspecified product 0.0013 0.0095 0.0222
Loa Loa (eye worm) hypothetical protein 0.0046 0.052 0.1299
Entamoeba histolytica cysteine proteinase 2 0.0008 0.0038 0.0295
Entamoeba histolytica cysteine proteinase, putative 0.0008 0.0038 0.0295
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0038 0.0413 0.1031
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.0429 0.1047
Entamoeba histolytica cysteine protease, putative 0.0008 0.0038 0.0295
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0956
Schistosoma mansoni hypothetical protein 0.01 0.1204 0.1314
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0956
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0653 0.1452
Echinococcus multilocularis solute carrier family 22 0.0018 0.0157 0.0144
Trichomonas vaginalis sugar transporter, putative 0.0039 0.0429 0.274
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0048 0.0053
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.1536 0.1666
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0429 0.1057
Trichomonas vaginalis sugar transport protein, putative 0.0018 0.0157 0.0956
Toxoplasma gondii exonuclease III APE 0.0019 0.0169 0.0368
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0956
Brugia malayi Cathepsin L-like cysteine proteinase 0.0011 0.0071 0.0177
Brugia malayi Sugar transporter family protein 0.0018 0.0157 0.0392
Schistosoma mansoni hypothetical protein 0.0046 0.052 0.0568
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0056 0.0062
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0956
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0146 0.1792 0.4478
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0044 0.0492 0.1213
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0726 0.1779
Echinococcus granulosus cathepsin L cysteine protease 0.0008 0.0038 0.0028
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.029 0.064
Schistosoma mansoni lysyl-tRNA synthetase 0.0028 0.0289 0.0316
Schistosoma mansoni cpg binding protein 0.003 0.0309 0.0338
Onchocerca volvulus 0.0016 0.014 0.0545
Leishmania major cathepsin L-like protease 0.0016 0.014 0.0333
Onchocerca volvulus 0.0028 0.0289 0.1195
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.004 0.0101
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0411 0.9964
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0168 0.042
Trypanosoma cruzi hypothetical protein, conserved 0.0006 0.0005 0.0011
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0404 0.0997
Entamoeba histolytica G protein alpha subunit, putative 0.0014 0.0106 0.1126
Plasmodium vivax calcium-dependent protein kinase, putative 0.0039 0.0423 0.0627
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0056 0.0047
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0014 0.0106 0.0093
Echinococcus granulosus FTZ F1 alpha 0.001 0.0056 0.0047
Echinococcus granulosus glycyl tRNA synthetase 0.0007 0.0021 0.0009
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0411 0.4886
Onchocerca volvulus 0.0014 0.0106 0.0398
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.014 0.1541
Entamoeba histolytica cysteine proteinase, putative 0.0011 0.0071 0.0692
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0157 0.0956
Plasmodium falciparum cGMP-dependent protein kinase 0.0006 0.0013 0.0013
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0956
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0195 0.0482
Trichomonas vaginalis ran, putative 0.0021 0.0195 0.121
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0014 0.0106 0.0116
Plasmodium vivax vivapain-3 0.0008 0.0038 0.0057
Echinococcus multilocularis geminin 0.0516 0.6489 0.6485
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0014 0.0106 0.0624
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0154 0.1884 0.4643
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0014 0.0106 0.0265
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0754 0.1884
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.014 0.0152
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0048 0.0035
Loa Loa (eye worm) hypothetical protein 0.0014 0.0106 0.0265
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0042 0.0104
Brugia malayi ecdysteroid receptor 0.001 0.0056 0.0141
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0168 0.0414
Entamoeba histolytica hypothetical protein 0.007 0.0826 1
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0014 0.0106 0.0116
Onchocerca volvulus 0.0018 0.0157 0.0619
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0028 0.0289 0.0713
Echinococcus granulosus cysteine protease 0.0008 0.0038 0.0028
Plasmodium vivax hexose transporter 0.0126 0.1536 0.2278
Schistosoma mansoni hypothetical protein 0.0302 0.3766 0.4113
Leishmania major cathepsin L-like protease 0.0062 0.0726 0.1779
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0956
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.014 0.0845
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0038 0.0413 0.2634
Onchocerca volvulus 0.0018 0.0157 0.0619
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0195 0.0488
Brugia malayi Latrophilin receptor protein 2 0.0046 0.052 0.1299
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0006 0.001 0.0011
Trypanosoma cruzi guanine nucleotide releasing protein, putative 0.0007 0.0015 0.0036
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.2877 0.3132
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0012 0.0008
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0195 0.0428
Mycobacterium ulcerans hypothetical protein 0.0006 0.0011 0.003
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.014 0.0349
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.09 0.1329
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0126 0.1536 0.1525
Brugia malayi lysyl-tRNA synthetase 0.0028 0.0289 0.0723
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.032 0.4003 0.4364
Trichomonas vaginalis sugar transporter, putative 0.0039 0.0429 0.274
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.014 0.0845
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.032 0.4003 0.4364
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0168 0.0779
Trypanosoma cruzi hexose transporter 0.0039 0.0429 0.1057
Echinococcus granulosus dnaJ subfamily B 0.0401 0.5027 0.5483
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0034 0.0366 0.0386
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0056 0.0062
Trypanosoma brucei glucose transporter, putative 0.0039 0.0429 0.1047
Echinococcus granulosus microtubule associated protein 2 0.0725 0.9157 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0157 0.0392
Schistosoma mansoni DNA polymerase eta 0.0019 0.0168 0.0184
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0008 0.0038 0.0095
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.014 0.0349
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0007 0.0021 0.0069
Brugia malayi hypothetical protein 0.0009 0.0048 0.012
Onchocerca volvulus 0.0018 0.0157 0.0619
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0726 0.1779
Echinococcus granulosus son of sevenless 1 0.0007 0.0015 0.0002
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.002 0.0022
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0012 0.0008
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0048 0.0038
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0195 0.0183
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0038 0.0413 0.4904
Giardia lamblia Prolyl-tRNA synthetase 0.0038 0.0413 1
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.014 0.0344
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0195 0.0482
Giardia lamblia Hexose transporter 0.0018 0.0157 0.3728
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0404 0.0392
Loa Loa (eye worm) hypothetical protein 0.0009 0.0048 0.012
Loa Loa (eye worm) hypothetical protein 0.001 0.0056 0.0141
Brugia malayi polk-prov protein 0.0006 0.0005 0.0012
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0014 0.0106 0.0265
Schistosoma mansoni hypothetical protein 0.0046 0.052 0.0568
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0956
Entamoeba histolytica Ran family GTPase 0.0021 0.0195 0.2229
Plasmodium falciparum calcium-dependent protein kinase 5 0.0039 0.0423 0.0621
Entamoeba histolytica cysteine protease, putative 0.0008 0.0038 0.0295
Plasmodium falciparum calcium-dependent protein kinase 3 0.0039 0.0423 0.0621
Onchocerca volvulus 0.0018 0.0157 0.0619
Entamoeba histolytica cysteine protease, putative 0.0008 0.0038 0.0295
Giardia lamblia Lysyl-tRNA synthetase 0.0028 0.0289 0.6978
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0044 0.0492 0.1093
Loa Loa (eye worm) cysteine protease 0.0016 0.014 0.0349
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0324 0.4058 1
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0028 0.0289 0.6932
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0039 0.0423 0.1056
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0157 0.0392
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0056 0.0141
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0038 0.0413 1
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0956
Loa Loa (eye worm) hypothetical protein 0.001 0.0056 0.0141
Loa Loa (eye worm) hypothetical protein 0.01 0.1204 0.3007
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0006 0.0011 0.0027
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0056 0.0043
Schistosoma mansoni ras GTP exchange factor 0.0007 0.0015 0.0016
Onchocerca volvulus 0.0011 0.0071 0.0245
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0014 0.0106 0.0116
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0404 0.2581
Schistosoma mansoni ran 0.0021 0.0195 0.0213
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.014 0.0845
Trypanosoma brucei PAB1-binding protein , putative 0.0076 0.09 0.221
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0056 0.0047
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0039 0.0423 0.0937
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.014 0.0845
Echinococcus multilocularis cpg binding protein 0.003 0.0309 0.0297
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0056 0.0141
Loa Loa (eye worm) hypothetical protein 0.001 0.0056 0.0141
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0012 0.0008
Trichomonas vaginalis glucose transporter, putative 0.0039 0.0429 0.274
Schistosoma mansoni transcription factor LCR-F1 0.007 0.0826 0.0902
Brugia malayi cathepsin L-like precursor 0.0011 0.0071 0.0177
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0014 0.0106 0.0624
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0056 0.0141
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0956
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.014 0.0845
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0048 0.0038
Entamoeba histolytica cysteine protease, putative 0.0008 0.0038 0.0295
Giardia lamblia DINP protein human, muc B family 0.0019 0.0168 0.4008
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0169 0.4027
Loa Loa (eye worm) hypothetical protein 0.0014 0.0106 0.0265
Brugia malayi Inositol-1 0.0037 0.0404 0.101
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0455 0.291
Onchocerca volvulus 0.0016 0.014 0.0545
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0012 0.0008
Brugia malayi Cam kinase protein 1 0.0039 0.0423 0.1056
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0169 0.1036
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0014 0.0106 0.0265
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.0429 0.1047
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0014 0.0106 0.0116
Trypanosoma brucei glucose transporter, putative 0.0039 0.0429 0.1047
Onchocerca volvulus 0.001 0.0056 0.0183
Echinococcus multilocularis importin subunit beta 1 0.0028 0.029 0.0278
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0036
Onchocerca volvulus 0.0018 0.0157 0.0619
Schistosoma mansoni hypothetical protein 0.0047 0.0532 0.0581
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0169 0.1902
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.0071 0.0077
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0008 0.0038 0.0042
Entamoeba histolytica cysteine protease, putative 0.0008 0.0038 0.0295
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0016 0.0129 0.0321
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0455 0.0483
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0146 0.1792 0.4478
Schistosoma mansoni glycyl-tRNA synthetase 0.0007 0.0021 0.0023
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0039 0.0423 0.0448
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0168 0.0155
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.014 0.0845
Entamoeba histolytica cysteine proteinase, putative 0.0008 0.0038 0.0295
Schistosoma mansoni hypothetical protein 0.0046 0.052 0.0568
Trypanosoma brucei glucose transporter, putative 0.0039 0.0429 0.1047
Loa Loa (eye worm) sugar transporter 0.0126 0.1536 0.3837
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0012 0.0008
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.014 0.0845
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0956
Leishmania major protein kinase, putative 0.0039 0.0423 0.1031
Echinococcus granulosus Protein son of sevenless 0.0007 0.0015 0.0002
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0455 0.1009
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0014 0.0106 0.0624
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0169 0.0405
Echinococcus granulosus lysyl tRNA synthetase 0.0028 0.0289 0.0302
Echinococcus granulosus synaptic vesicle 2 protein 0.0018 0.0157 0.0157
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.014 0.0845
Echinococcus multilocularis dna polymerase eta 0.0019 0.0168 0.0155
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0039 0.0423 0.0937
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0169 0.0244
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0168 0.0751
Trichomonas vaginalis myo-inositol transporter, putative 0.0018 0.0157 0.0956
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0039 0.0423 0.041
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0168 0.042
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.029 0.0705
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0008 0.0038 0.0181
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.069 0.0753
Echinococcus multilocularis ras GTP exchange factor 0.0007 0.0015 0.0001
Echinococcus multilocularis dnaJ subfamily B 0.0401 0.5027 0.502
Entamoeba histolytica cysteine protease, putative 0.0008 0.0038 0.0295
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.014 0.0127
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0056 0.0141
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0044 0.0492 0.1203
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0039 0.0423 0.1056
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0056 0.0141
Entamoeba histolytica hypothetical protein 0.007 0.0826 1
Plasmodium falciparum protein kinase 6 0.0536 0.6743 1
Leishmania major lysyl-tRNA synthetase, putative 0.0028 0.0289 0.0702
Schistosoma mansoni dishevelled 0.0009 0.0048 0.0053
Loa Loa (eye worm) G protein alpha subunit 3 0.0014 0.0106 0.0265
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0956
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0056 0.0047
Brugia malayi hypothetical protein 0.0076 0.09 0.225
Onchocerca volvulus 0.0014 0.0106 0.0398
Leishmania major importin beta-1 subunit, putative 0.0023 0.0222 0.0537
Leishmania major GTP-binding protein, putative 0.0021 0.0195 0.0471
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0956
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.014 0.0845
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0012 0.0008
Plasmodium vivax DNA repair protein REV1, putative 0.0006 0.0005 0.0007
Loa Loa (eye worm) latrophilin receptor protein 2 0.0046 0.052 0.1299
Loa Loa (eye worm) hypothetical protein 0.0018 0.0157 0.0392
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0012 0.0008
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0014 0.0106 0.0093
Onchocerca volvulus 0.0018 0.0157 0.0619
Echinococcus granulosus expressed protein 0.0014 0.0106 0.0102
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0048 0.0035
Echinococcus multilocularis General substrate transporter 0.0108 0.131 0.1299
Loa Loa (eye worm) major facilitator superfamily transporter 0.0018 0.0157 0.0392
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0222 0.1387
Leishmania major protein kinase, putative 0.0006 0.0013 0.0021
Brugia malayi G-protein alpha subunit 0.0014 0.0106 0.0265
Loa Loa (eye worm) hypothetical protein 0.0009 0.0048 0.012
Leishmania major cathepsin L-like protease 0.0016 0.014 0.0333
Echinococcus multilocularis expressed protein 0.0014 0.0106 0.0093
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0169 1
Treponema pallidum prolyl-tRNA synthetase 0.0013 0.0101 0.5407
Trypanosoma cruzi hypothetical protein, conserved 0.0006 0.0005 0.0011
Leishmania major hypothetical protein, conserved 0.0018 0.0157 0.0375
Echinococcus multilocularis cysteine protease 0.0016 0.014 0.0127
Brugia malayi Calcitonin receptor-like protein seb-1 0.0146 0.1792 0.4478
Trypanosoma cruzi glucose transporter, putative 0.0018 0.0157 0.0386
Plasmodium vivax unspecified product 0.0008 0.0038 0.0057
Brugia malayi glycyl-tRNA synthetase 0.0007 0.0021 0.0053
Trypanosoma brucei glucose transporter 1E 0.0039 0.0429 0.1047
Plasmodium vivax CDK-related protein kinase 6, putative 0.0536 0.6743 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0455 0.0674
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0956
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0056 0.0047
Echinococcus granulosus General substrate transporter 0.0108 0.131 0.1419
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0168 0.0414
Trypanosoma cruzi cysteine proteinase, putative 0.0008 0.0038 0.0095
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0404 0.0896
Schistosoma mansoni sugar transporter 0.0018 0.0157 0.0171
Brugia malayi Cathepsin L-like precursor 0.0016 0.014 0.0349
Onchocerca volvulus 0.0047 0.0532 0.2254
Brugia malayi latrophilin 2 splice variant baaae 0.01 0.1204 0.3007
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0056 0.0141
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0014 0.0106 0.0624
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0404 0.2581
Loa Loa (eye worm) hypothetical protein 0.0018 0.0157 0.0392
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0956
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0404 0.4804
Schistosoma mansoni ran 0.0021 0.0195 0.0213
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0014 0.0106 0.0624
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.014 0.1541
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0014 0.0106 0.0265
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0168 0.0184
Plasmodium vivax sugar transporter, putative 0.0018 0.0157 0.0232
Brugia malayi Cathepsin L-like precursor 0.0011 0.0071 0.0177
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.014 0.0845
Trypanosoma brucei Aminoacyl-tRNA editing domain containing protein, putative 0.0006 0.0011 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0012 0.0008
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0204 0.2525 0.3744
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0014 0.0106 0.0265
Schistosoma mansoni glucose transport protein 0.0126 0.1536 0.1678
Echinococcus multilocularis synaptic vesicle 2 protein 0.0018 0.0157 0.0144
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0726 0.1779
Giardia lamblia Threonyl-tRNA synthetase 0.0007 0.0021 0.041
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0168 0.0779
Brugia malayi hypothetical protein 0.0232 0.2877 0.7187
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.0007 0.0021 0.0084
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0399 0.0983
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.014 0.0845
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0195 0.0283
Plasmodium vivax vivapain-2 0.0016 0.014 0.0207
Toxoplasma gondii YbaK/proline-tRNA ligase associated domain-containing protein 0.0006 0.0011 0.0014
Plasmodium vivax proline--tRNA ligase, putative 0.0044 0.0492 0.073
Toxoplasma gondii hypothetical protein 0.0009 0.0048 0.0098
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0007 0.0021 0.008
Loa Loa (eye worm) hypothetical protein 0.001 0.0056 0.0141
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0168 0.1031
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0455 0.291
Onchocerca volvulus Putative transporter 0.0018 0.0157 0.0619
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.014 0.0845
Onchocerca volvulus 0.0018 0.0157 0.0619
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0168 0.0403
Loa Loa (eye worm) major facilitator superfamily transporter 0.0018 0.0157 0.0392
Trypanosoma brucei unspecified product 0.0013 0.0095 0.0222
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0399 0.0422
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0726 0.1789
Schistosoma mansoni protein kinase 0.0039 0.0423 0.0461
Schistosoma mansoni sugar transporter 0.0018 0.0157 0.0171
Schistosoma mansoni protein kinase 0.0039 0.0423 0.0461
Schistosoma mansoni glucose transport protein 0.0126 0.1536 0.1678
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.0007 0.0015 0.0002
Schistosoma mansoni coup transcription factor 0.001 0.0056 0.0062
Loa Loa (eye worm) hypothetical protein 0.0014 0.0106 0.0265
Loa Loa (eye worm) hypothetical protein 0.0031 0.0322 0.0805
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0404 0.0428
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0168 0.0414
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0008 0.0038 0.0042
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0429 0.1057
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0404 0.2581
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0036
Echinococcus granulosus cathepsin l1 0.0016 0.014 0.0138
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0012 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0157 0.0956
Loa Loa (eye worm) hypothetical protein 0.0028 0.0289 0.0723
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0429 0.274
Echinococcus granulosus calcium dependent protein kinase 0.0036 0.0392 0.0415
Plasmodium vivax threonine--tRNA ligase, putative 0.0007 0.0021 0.0032
Trypanosoma brucei sugar transporter, putative 0.0018 0.0157 0.0375
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0169 0.0416
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0014 0.0106 0.0116
Brugia malayi Cathepsin L-like precursor 0.0016 0.014 0.0349
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0018 0.0157 0.0144
Onchocerca volvulus 0.0016 0.014 0.0545
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0056 0.0043
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0399 0.0386
Loa Loa (eye worm) hypothetical protein 0.0018 0.0157 0.0392
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0399 0.0435
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.0657 0.1619
Brugia malayi hypothetical protein 0.0049 0.0557 0.1391
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0046 0.052 0.0554
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0956
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0056 0.0141
Trichomonas vaginalis sugar transporter, putative 0.0039 0.0429 0.274
Leishmania major cathepsin L-like protease 0.0062 0.0726 0.1779
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.029 0.0705
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0056 0.0062
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.014 0.1712 0.1701
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0039 0.0423 0.1056
Brugia malayi DIX domain containing protein 0.0009 0.0048 0.012
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.014 0.0845
Mycobacterium tuberculosis Conserved hypothetical protein 0.0171 0.2105 1
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0956
Loa Loa (eye worm) hypothetical protein 0.0011 0.0071 0.0177
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.0048 0.012
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0046 0.052 0.0508
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0726 0.1779
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0168 0.0751
Leishmania major cathepsin L-like protease 0.0016 0.014 0.0333
Trypanosoma cruzi DNA polymerase eta, putative 0.0006 0.0005 0.0011
Brugia malayi Egg laying defective protein 4 0.0006 0.0013 0.0033
Schistosoma mansoni ap endonuclease 0.0019 0.0169 0.0184
Entamoeba histolytica hypothetical protein 0.007 0.0826 1
Brugia malayi Cathepsin L-like precursor 0.0016 0.014 0.0349
Trichomonas vaginalis ras GTP exchange factor, son of sevenless, putative 0.0007 0.0015 0.0024
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0726 0.1779
Toxoplasma gondii hypothetical protein 0.0052 0.0597 0.1327
Onchocerca volvulus 0.0018 0.0157 0.0619
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0015 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.014 0.0845
Echinococcus multilocularis solute carrier family 22 0.0018 0.0157 0.0144
Plasmodium vivax lysine--tRNA ligase, putative 0.0028 0.0289 0.0429
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0168 0.017
Trypanosoma cruzi DNA damage repair protein, putative 0.0006 0.0005 0.0011
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0056 0.0141
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0754 0.0824
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0048 0.012
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0556 0.1369
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0154 0.1884 0.4637
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0007 0.0021 0.0053
Toxoplasma gondii lysine-tRNA ligase 0.0028 0.0289 0.0638
Schistosoma mansoni dep domain containing protein 0.0009 0.0048 0.0053
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0168 0.0403
Onchocerca volvulus 0.0018 0.0157 0.0619
Echinococcus granulosus Sugar transporter ERD6 protein 0.0018 0.0157 0.0157
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0014 0.0106 0.0265
Trypanosoma cruzi DNA damage repair protein, putative 0.0006 0.0005 0.0011
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0008 0.003 0.0062
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0168 0.0403
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0018 0.0157 0.0697
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.014 0.02
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0956
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0168 0.0403
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.014 0.0127
Echinococcus multilocularis GPCR, family 2 0.0046 0.052 0.0508
Plasmodium falciparum calcium-dependent protein kinase 1 0.0039 0.0423 0.0621
Schistosoma mansoni hypothetical protein 0.0046 0.052 0.0568
Loa Loa (eye worm) hypothetical protein 0.0039 0.0423 0.1056
Leishmania major myo-inositol/proton symporter (MIT) 0.0018 0.0157 0.0375
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0168 0.0403
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0007 0.0021 0.0037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0056 0.0141
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0754 0.1884
Loa Loa (eye worm) hypothetical protein 0.0028 0.029 0.0725
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0056 0.0043
Loa Loa (eye worm) RasGEF domain-containing protein 0.0007 0.0015 0.0036
Schistosoma mansoni sugar transporter 0.0018 0.0157 0.0171
Schistosoma mansoni sugar transporter 0.0018 0.0157 0.0171
Schistosoma mansoni nuclear hormone receptor 0.001 0.0056 0.0062
Brugia malayi Cathepsin L-like precursor 0.0016 0.014 0.0349
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0056 0.0062
Toxoplasma gondii LsmAD domain-containing protein 0.0076 0.09 0.2008
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0038 0.0413 0.04
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0956
Brugia malayi Cathepsin L-like precursor 0.0011 0.0071 0.0177
Toxoplasma gondii protein kinase, putative 0.0357 0.4466 1
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0056 0.0141
Leishmania major hypothetical protein, conserved 0.0006 0.0011 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0056 0.0141
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0195 0.0199
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.014 0.0845
Loa Loa (eye worm) inositol-1 0.0037 0.0404 0.101
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0169 0.3852
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0095 0.0222
Leishmania major glucose transporter, lmgt2 0.0039 0.0429 0.1047
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0399 0.0422
Echinococcus multilocularis cysteine protease 0.0016 0.014 0.0127
Loa Loa (eye worm) hypothetical protein 0.0018 0.0157 0.0392
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0169 0.017
Loa Loa (eye worm) hypothetical protein 0.0232 0.2877 0.7187
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0014 0.0106 0.0265
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0404 0.0997
Onchocerca volvulus 0.0018 0.0157 0.0619
Trypanosoma brucei glucose transporter 2A 0.0039 0.0429 0.1047
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0956
Chlamydia trachomatis lysine--tRNA ligase 0.0028 0.0289 1
Brugia malayi N-terminal motif family protein 0.0187 0.231 0.5772
Toxoplasma gondii facilitative glucose transporter GT1 0.0126 0.1536 0.3433
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0028 0.0289 0.0702
Schistosoma mansoni hypothetical protein 0.0516 0.6489 0.7087
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.032 0.4003 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0222 0.0548
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0157 0.0956
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0007 0.0021 0.0008
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0025 0.0245 0.1536
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0956
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0048 0.0038
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0042 0.0029
Plasmodium falciparum calcium-dependent protein kinase 2 0.0039 0.0423 0.0621
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0008 0.0038 0.0042
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0014 0.0106 0.0624
Trichomonas vaginalis ras GTP exchange factor, putative 0.0007 0.0015 0.0024
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0028 0.0289 0.1355
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0157 0.0392
Plasmodium falciparum protein kinase 7 0.0357 0.4466 0.662
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.1536 0.1666
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0726 0.1779
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.014 0.0845
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.0429 0.1047
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.0511 0.126
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.014 0.0845
Loa Loa (eye worm) hypothetical protein 0.0019 0.0168 0.042
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0034 0.0366 0.0353
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0015 0.0016
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0014 0.0106 0.0624
Leishmania major DNA polymerase eta, putative 0.0019 0.0168 0.0403
Entamoeba histolytica cysteine protease, putative 0.0008 0.0038 0.0295
Schistosoma mansoni serine/threonine protein kinase 0.0006 0.0013 0.0014
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0046 0.052 0.1299
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0324 0.4058 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0168 0.0403
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0169 0.0782
Loa Loa (eye worm) hypothetical protein 0.0037 0.0399 0.0996
Schistosoma mansoni serine/threonine protein kinase 0.0006 0.0013 0.0014
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0754 0.0824
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0157 0.0392
Trypanosoma cruzi hypothetical protein, conserved 0.0006 0.0011 0.0027
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.0007 0.0015 0.0001
Plasmodium falciparum hexose transporter 0.0126 0.1536 0.2273
Brugia malayi Papain family cysteine protease containing protein 0.0008 0.0038 0.0096
Toxoplasma gondii sugar transporter ST3 0.0018 0.0157 0.0341
Schistosoma mansoni ap endonuclease 0.0019 0.0169 0.0184
Schistosoma mansoni inositol monophosphatase 0.0037 0.0404 0.0442
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.032 0.4003 1
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0014 0.0106 0.0102
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0007 0.0021 0.005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.032 0.4003 0.4372
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0169 0.0405
Toxoplasma gondii cathepsin CPL 0.0016 0.014 0.0303
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0222 0.1387
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0169 0.0755
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0726 0.1789
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0056 0.0047
Loa Loa (eye worm) RNA binding protein 0.0065 0.0754 0.1884
Echinococcus granulosus solute carrier family 22 0.0018 0.0157 0.0157
Entamoeba histolytica cysteine protease, putative 0.0008 0.0038 0.0295
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0399 0.0386
Entamoeba histolytica cysteine protease, putative 0.0008 0.0038 0.0295
Loa Loa (eye worm) hypothetical protein 0.0016 0.014 0.0349
Trypanosoma brucei glucose transporter, putative 0.0039 0.0429 0.1047
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0168 0.0403
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0042 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0399 0.2543
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0008 0.0038 0.0084
Echinococcus granulosus solute carrier family 22 0.0018 0.0157 0.0157
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0754 0.0742
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0007 0.0021 0.008
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0012 0.0008
Entamoeba histolytica cysteine protease, putative 0.0008 0.0038 0.0295
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.014 0.0845
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0014 0.0106 0.0093
Brugia malayi hypothetical protein 0.0018 0.0157 0.0392
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0754 0.0824
Brugia malayi N-terminal motif family protein 0.0007 0.0015 0.0036
Trypanosoma cruzi cysteine peptidase, putative 0.0008 0.0038 0.0095
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0048 0.0038
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0157 0.0956
Brugia malayi RNA, U transporter 1 0.008 0.0953 0.238
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0754 0.0824
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0039 0.0423 0.0448
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0007 0.0015 0.0016
Loa Loa (eye worm) hypothetical protein 0.0018 0.0157 0.0392
Trypanosoma cruzi hypothetical protein 0.0007 0.0015 0.0036
Echinococcus multilocularis calcium dependent protein kinase 0.0036 0.0392 0.038
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0039 0.0423 0.0627
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0195 0.029
Loa Loa (eye worm) hypothetical protein 0.0006 0.0005 0.0012
Brugia malayi nuclear receptor NHR-88 0.001 0.0056 0.0141
Entamoeba histolytica hypothetical protein 0.007 0.0826 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0168 0.0403
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0169 0.0156
Toxoplasma gondii transporter, major facilitator family protein 0.0018 0.0157 0.0341
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0168 0.0403
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.014 0.0349
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0168 0.0155

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 1030 nM MMV: Inhibition of Plasmodium falciparum 3D7 (EC50). ChEMBL. No reference
Growth Inhibition (functional) = 16.818 % MMV: Measure of pLDH activity as indication of parasite viability. Gametocytogenesis of 3D7 Plasmodium falciparum strain was induced in vitro and asexual parasites were depleted with N-acetylglucosamine. Gametocytes were treated with dihydroartemisinin, epoxomicin, methylene blue, primaquine, puromycin or chloroquine in 96-well plates and the pLDH activity was evaluated using a modified Makler protocol. Mosquito infectivity was measured by the standard membrane feeding assay. ChEMBL. No reference
IC50 (functional) > 12000 nM ST_JUDE_LEISH: Cytotoxicity against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
IC50 (functional) > 12000 nM ST_JUDE_LEISH: Cytotoxicity against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
IC50 (functional) > 12000 nM ST_JUDE_LEISH: Cytotoxicity against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro ChEMBL. No reference
IC50 (functional) > 1 uM MMV: PK7 Protein kinase inhibition assay using recombinant PfPK7, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. Final concentrations were 1 uM ATP, 2 mM DTT, 20 mM MgCl2, 2 mM MnCl2, 0.01% BSA, and 6 ug/ml PK7, in a buffer of 20 mM Tris-HCl (pH 7.5). The enzyme itself was the only substrate present (since autophosphorylation occurs); 100 uM 1NA-PP1 was used as a control inhibitor. Incubation time was 3 hours. ChEMBL. No reference
IC50 (functional) > 1 uM MMV: MAP2K Protein kinase inhibition assay using recombinant PfMAP2K, protein substrate, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. Final concentrations were 1 uM ATP, 0.5 mM DTT, 1 mM MgCl2, 0.5 mg/mL BSA, and 10 ug/ml MAP2 in a buffer of 50 mM HEPES (pH 7.0). 0.5 mg/mL histone III-S served as the substrate (13); 100 uM AMP-PNP, an ATP analog, was used as a control inhibitor. Incubation time was 4 hours. ChEMBL. No reference
IC50 (functional) > 1 uM MMV: PK6 Protein kinase inhibition assay using recombinant PfPK6, Myelin Basic Protein (MBP) substrate, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. Final concentrations were 1.5 uM ATP, 5 mM MnCl2, and 15 ug/ml PK6 in a buffer of 100 mM Tris-HCl (pH 7.5). 50 ug/mL MBP was provided as the substrate; 10 uM staurosporine was used as a control inhibitor. Incubation time was 3 hours and 40 minutes.The catalytic activity of each kinase was considered proportional to ATP consumed, as determined from measurements of residual [ATP] with the luciferase-based reagent Kinase-Glo (Promega) following incubation. Luminescence (proportional to residual [ATP]) was measured on the plate readers FLx800 (BioTek Instruments, Winooski, VT, USA) and MicroBeta2. ChEMBL. No reference
IC50 (functional) > 1 uM MMV: CDPK1 Protein kinase inhibition assay using recombinant PfCDPK1, syntide 2 peptide substrate, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. ChEMBL. No reference
IC50 (functional) > 1 uM MMV: CDPK4 Protein kinase inhibition assay using recombinant PfCDPK4, syntide2 peptide substrate, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. ChEMBL. No reference
IC50 (functional) > 2.5 uM MMV: ProRS recombinant Plasmodium falciparum Prolyl-tRNA-synthetase, assay with yeast tRNA, ATP, and proline and 3 uM MMV malaria box compound, assay read out with kinase glo as % inhibition. ChEMBL. No reference
IC50 (functional) > 2.5 uM MMV: KRS recombinant Plasmodium falciparum Lysyl-tRNA-synthetase, assay with yeast tRNA, ATP, and lysine and 3 uM MMV malaria box compound, assay read out with kinase glo as % inhibition. ChEMBL. No reference
IC50 (functional) = 10.314962387085 uM MMV: Inhibition of Trypanosoma brucei rhodesiense (STIB 900) (HAT in vitro). ChEMBL. No reference
IC50 (functional) = 10.46 uM MMV: A total of 100ul of inoculum was added to each well (parasite/cell ratio, ~10:1; final volume, 200 ul). Six hours after inoculation, nonadherent parasites were removed, and 100 ul of complete DMEM (1% penicillin-streptomycin, 3% FBS) supplemented with inhibitors at different concentrations (2-fold serial dilutions starting from 30 uM) was added to all except the negative-control wells. Positive controls, consisting of pyrimethamine (PYR) and sulfadiazine (SDZ) (20-mg/ml stocks in DMSO), were tested at a 2mg/ml final concentration. Each test was performed in triplicate. ChEMBL. No reference
IC50 (functional) = 15.441253662109375 uM MMV: Inhibition of Trypanosoma cruzi (Tulahuen C4 LacZ) (Chagas in vitro). ChEMBL. No reference
IC50 (functional) = 15.4412536621094 uM MMV: Inhibition of Trypanosoma cruzi (Tulahuen C4 LacZ) (Chagas in vitro). ChEMBL. No reference
IC50 (functional) = 15.4923963546753 uM MMV: Inhibition of Trypanosoma brucei brucei (Squib 427) (HAT in vitro). ChEMBL. No reference
IC50 (functional) > 30 uM MMV: Primary screening was performed with each compound at a 30 uM final concentration and in triplicate in sealed 96-well polystyrene microtiter plates. Parasite inocula (100 ul) comprising 20000 parasites/ml were added to each well and grown at 37 degrees C in a humidified atmosphere of 5% CO2 for 72 h. Positive controls consisted of metronidazole at 1 mg/ml. The growth of E. histolytica trophozoites in each well was determined microscopically by measuring the diameters of the confluent cells in drug-containing wells relative to those in the nega- tive-control wells. ChEMBL. No reference
IC50 (functional) > 32 uM MMV: Inhibition of Leishmania infantum (MHOM/MA/BE/67) in vitro. ChEMBL. No reference
IC50 > 32 uM MMV: Cytotoxicity against human fibroblasts (MRC-5) cells. ChEMBL. No reference
Inhibition (functional) = -13.9973203343981 % MMV: P. falciparum NF54 functionally mature Stage V gametocytes were incubated for 24 hr in the presence of the test compounds. Gamete formation was then triggered by addition of 2uM xantheurenic acid and temperature decrease to ~20C. Female gamete formation was recorded 24 hr later by automated microscopy detection of surface labelling of female gametes with a Cy3-conjugated antibody reactive to Pfs25. All compounds were tested in 4 independent experiments and data presented here is the mean. ChEMBL. No reference
Inhibition (functional) = -4 % MMV: Malaria Box compounds were tested for inhibition of the human ether a go-go related gene (hERG), Kv11.1 channel, using IonWorks 384-well patch clamp electrophysiology at 1.1uM (3 independent assay plates up to 12 cells per concentration). ChEMBL. No reference
Inhibition (functional) = -0.638 % MMV: Screen against Mtb, single point, non replicating, at 25uM ChEMBL. No reference
Inhibition (functional) = 0 % GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. ChEMBL. 20485427
Inhibition (functional) = 1 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 2.74 % MMV: Screen against Mtb, single point, replicating, at 25uM ChEMBL. No reference
Inhibition (functional) = 7.25 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 10 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 11.34 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 19.150255243832255 % MMV: Cryptosporidium parvum oocysts (Iowa Strain) were prepared for use by treatment with 10 mM HCl (37 degrees C, 10 min) followed by 2 mM sodium taurocholate in phosphate-buffered saline (PBS) with Ca2+ and Mg2+ (16 degrees C, 10 min) in order to stimulate excystation. The high-throughput screen was carried out by inoculating >90% confluent human ileocecal adenocarcinoma (HCT-8) cells (ATCC) with ~5.5 x 10^3 primed oocysts per well. Experimental compounds or DMSO (vehicle) were added three hours after infection, and cells were incubated for 48 hours. ChEMBL. No reference
Inhibition (functional) = 19.1502552438323 % MMV: Cryptosporidium parvum oocysts (Iowa Strain) were prepared for use by treatment with 10 mM HCl (37 degrees C, 10 min) followed by 2 mM sodium taurocholate in phosphate-buffered saline (PBS) with Ca2+ and Mg2+ (16 degrees C, 10 min) in order to stimulate excystation. The high-throughput screen was carried out by inoculating >90% confluent human ileocecal adenocarcinoma (HCT-8) cells (ATCC) with ~5.5 x 10^3 primed oocysts per well. Experimental compounds or DMSO (vehicle) were added three hours after infection, and cells were incubated for 48 hours. ChEMBL. No reference
Inhibition (functional) = 25.6293098906826 % MMV: P. falciparum NF54 functionally mature Stage V gametocytes were incubated for 24 hr in the presence of the test compounds. Gamete formation was then triggered by addition of 2uM xantheurenic acid and temperature decrease to ~20C. Male gamete exflagellation was recorded and analysed by automated microscopy after 20 min. All compounds were tested in 4 independent experiments and data presented here is the mean. ChEMBL. No reference
Inhibition (functional) = 55 % MMV: Malaria Box compounds were tested for inhibition of the human ether a go-go related gene (hERG), Kv11.1 channel, using IonWorks 384-well patch clamp electrophysiology at 11.1uM (3 independent assay plates up to 12 cells per concentration). ChEMBL. No reference
Inhibition (functional) = 73.2150208843903 % MMV: P. berghei-infected blood was withdrawn from mice by cardiac pucture before being immediately added to ookinete culture medium containing test compounds. 26 hr later, GFP-positive ookinetes were identified and counted by automated microscopy. All compounds were tested in 4 independent experiments and data presented here is the mean. ChEMBL. No reference
Inhibition (functional) = 83 % GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 87 % MMV: Inhibition of Plasmodium falciparum 3D7 at 5uM compound concentration. ChEMBL. No reference
Inhibition (functional) = 92 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition frequency index (IFI) (functional) = 3 Inhibition Frequency Index (IFI) GSK. 20485427
Percent growth inhibition (functional) = -1 % Percent inhibition of HepG2 growth (at 10 uM) GSK. 20485427
Percent growth inhibition (functional) = 1 % Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 83 % Percent inhibition of P. falciparum Dd2 growth (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 92 % Percent inhibition of P. falciparum 3D7 growth (at 2 uM) GSK. 20485427
Ratio (functional) = 1 MMV: Compounds (1uM) were screened in a 72hr growth assay monitored by flow cytometry both in the presence and absence of supplemental isopentenyl pyrophosphate (IPP) 200uM. Compounds which fail to show anti-malarial activity when chemically rescued by IPP are therefore specific to the apicoplast. The values are expressed as the ratio of the corresponding activity with and without IPP, respectively. ChEMBL. No reference
Relative Growth (functional) = 0.0184 MMV: Growth assays were conducted using the prototrophic S. cerevisiae strain JHY222. Each MMV compound (0.1 mM) was tested in minimal media containing ethanol and glycerol as carbon sources (Yeast Nitrogen Base, Ethanol, Glycerol; YNBEG). The growth rate in the presence of each MMV compound was calculated as follows: (i) the first 10 OD readings were averaged and subtracted from all OD readings of the corresponding curve to set the baseline of the growth curve to zero, and (ii) the area under the curve (AUC) was then calculated as the sum of all OD readings. AUC was calculated following 180 OD readings, corresponding to roughly 45 h of growth. A relative growth value was calculated as follows: AUC(DRUG) - AUC(DMSO)/AUC(DMSO); where AUC(DMSO) represents growth measured in a DMSO control well that was on the same microtiter plate of the drug-treated culture. A relative growth value near zero means the compound had little or no effect on growth, whereas a value near -1 means the compound strongly or completely inhibited growth. ChEMBL. No reference
Relative Growth (functional) = 0.0426 MMV: Growth assays were conducted using the prototrophic S. cerevisiae strain JHY222. Each MMV compound (0.1 mM) was tested in rich media containing dextrose as a carbon source (Yeast Extract, Peptone, Dextrose; YPD). The growth rate in the presence of each MMV compound was calculated as follows: (i) the first 10 OD readings were averaged and subtracted from all OD readings of the corresponding curve to set the baseline of the growth curve to zero, and (ii) the area under the curve (AUC) was then calculated as the sum of all OD readings. AUC was calculated following 80 OD readings corresponding to roughly 20 h of growth. A relative growth value was calculated as follows: AUC(DRUG) - AUC(DMSO)/AUC(DMSO); where AUC(DMSO) represents growth measured in a DMSO control well that was on the same microtiter plate of the drug-treated culture. A relative growth value near zero means the compound had little or no effect on growth, whereas a value near -1 means the compound strongly or completely inhibited growth. ChEMBL. No reference
Relative Growth (functional) = 0.1664 MMV: Growth assays were conducted using the prototrophic S. cerevisiae strain JHY222. Each MMV compound (0.1 mM) was tested in minimal media containing dextrose as a carbon source (Yeast Nitrogen Base, Dextrose; YNBD). The growth rate in the presence of each MMV compound was calculated as follows: (i) the first 10 OD readings were averaged and subtracted from all OD readings of the corresponding curve to set the baseline of the growth curve to zero, and (ii) the area under the curve (AUC) was then calculated as the sum of all OD readings. AUC was calculated following 80 OD readings, corresponding to roughly 20 h of growth. A relative growth value was calculated as follows: AUC(DRUG) - AUC(DMSO)/AUC(DMSO); where AUC(DMSO) represents growth measured in a DMSO control well that was on the same microtiter plate of the drug-treated culture. A relative growth value near zero means the compound had little or no effect on growth, whereas a value near -1 means the compound strongly or completely inhibited growth. ChEMBL. No reference
Toxicity (functional) = 0 MMV: Toxicity @ 2.5 uM to newly transformed Schistosoma mansoni somules after 48 h on a scale of 0 (none) - 4 (most) as judged visually: includes short descriptors of effects (PMID:19597541). Caffrey group UCSF. ChEMBL. No reference
Toxicity (functional) = 0 MMV: Toxicity @ 2.5 uM to newly transformed Schistosoma mansoni somules after 72 h on a scale of 0 (none) - 4 (most) as judged visually: includes short descriptors of effects (PMID:19597541). Caffrey group UCSF. ChEMBL. No reference
Toxicity (functional) = 0 MMV: Toxicity @ 2.5 uM to newly transformed Schistosoma mansoni somules after 24 h on a scale of 0 (none) - 4 (most) as judged visually: includes short descriptors of effects (PMID:19597541). Caffrey group UCSF. ChEMBL. No reference
XC50 (functional) = 6.11 XC50 determination of P. falciparum 3D7 growth GSK. 20485427
XC50 (functional) = 0.77431 uM GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. ChEMBL. 20485427

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Trypanosoma brucei gambiense
Toxoplasma gondii ChEMBL23
Plasmodium falciparum ChEMBL23
Trypanosoma cruzi ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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