Detailed information for compound 653213

Basic information

Technical information
  • TDR Targets ID: 653213
  • Name: 1-[3-(3-fluorophenyl)-8-methoxy-3,3a,4,5-tetr ahydrobenzo[g]indazol-2-yl]propan-1-one
  • MW: 352.402 | Formula: C21H21FN2O2
  • H donors: 0 H acceptors: 1 LogP: 3.67 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1)C1=NN(C(C1CC2)c1cccc(c1)F)C(=O)CC
  • InChi: 1S/C21H21FN2O2/c1-3-19(25)24-21(14-5-4-6-15(22)11-14)17-10-8-13-7-9-16(26-2)12-18(13)20(17)23-24/h4-7,9,11-12,17,21H,3,8,10H2,1-2H3
  • InChiKey: DFEJTKMRGYGWSZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • Oprea1_048555

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0328 0.0328
Echinococcus granulosus lysine specific demethylase 6a 0.0019 0.005 0.005
Trypanosoma cruzi hypothetical protein, conserved 0.0147 0.0832 1
Mycobacterium tuberculosis Probable hydrolase 0.0147 0.0832 0.1448
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0038 0.0139
Loa Loa (eye worm) isocitrate dehydrogenase 0.0031 0.0127 0.0485
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0013 0.0015 0.0096
Echinococcus multilocularis cysteine protease 0.0017 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0019 0.005 0.0192
Plasmodium falciparum glutathione reductase 0.014 0.0789 1
Loa Loa (eye worm) thioredoxin reductase 0.014 0.0789 0.3023
Plasmodium vivax vivapain-2 0.0017 0.0038 0.0281
Onchocerca volvulus 0.0116 0.0643 0.246
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0052 0.0367
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0013 0.0015 0.0015
Onchocerca volvulus 0.002 0.0058 0.0218
Schistosoma mansoni zinc finger protein 0.0015 0.0029 0.0029
Brugia malayi Bloom's syndrome protein homolog 0.0042 0.019 0.0728
Brugia malayi nuclear hormone receptor 0.002 0.006 0.0231
Loa Loa (eye worm) hypothetical protein 0.0024 0.0085 0.0326
Loa Loa (eye worm) hypothetical protein 0.0018 0.0044 0.0167
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.0675 0.2588
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0016
Brugia malayi Doublecortin family protein 0.002 0.0058 0.0224
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0052 0.0367
Onchocerca volvulus 0.002 0.006 0.0225
Toxoplasma gondii PHD-finger domain-containing protein 0.0019 0.0052 0.0325
Echinococcus granulosus beta LACTamase domain containing family member 0.0147 0.0832 0.0832
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0014 0.0023 0.0023
Schistosoma mansoni jumonji/arid domain-containing protein 0.0079 0.0414 0.0414
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0017 0.0041 0.0157
Mycobacterium ulcerans lipase LipD 0.0147 0.0832 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0049 0.0232 0.2694
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.006 0.0231
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0014 0.0023 0.0023
Trypanosoma cruzi ISWI complex protein 0.0012 0.0011 0.0109
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0013 0.0015 0.0015
Trypanosoma cruzi target of rapamycin kinase 3 0.0019 0.0052 0.0607
Echinococcus granulosus jumonji domain containing 1A 0.0019 0.005 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0052 0.0367
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0328 0.0328
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0323 0.3813
Onchocerca volvulus 0.0011 0.0004 0.001
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0038 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0097 0.0692
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0058 0.0534
Trypanosoma cruzi NADH dehydrogenase, putative 0.0013 0.0015 0.0159
Mycobacterium ulcerans beta-lactamase 0.0147 0.0832 1
Echinococcus multilocularis Protein lozenge 0.0055 0.0272 0.0272
Loa Loa (eye worm) hypothetical protein 0.002 0.006 0.0231
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0153 0.0153
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.006 0.0231
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0002 0.0002
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0825 0.4949 0.4949
Onchocerca volvulus 0.0032 0.0131 0.0496
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0002 0.0002
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0019 0.0052 0.0607
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0038 0.0436
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0052 0.0367
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0019 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.007 0.0363 0.1392
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0049 0.0232 0.2773
Schistosoma mansoni hypothetical protein 0.002 0.0061 0.0061
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0038 0.0264
Onchocerca volvulus Bile acid receptor homolog 0.002 0.006 0.0225
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0052 0.0367
Onchocerca volvulus 0.0017 0.0038 0.0139
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0515 0.0515
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.006 0.006
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0026 0.0095 0.103
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0136 0.0136
Leishmania major hypothetical protein, conserved 0.0015 0.0029 0.022
Schistosoma mansoni hypothetical protein 0.0676 0.4042 0.4042
Brugia malayi beta-lactamase family protein 0.0147 0.0832 0.3188
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0038 0.0145
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0323 0.3868
Onchocerca volvulus 0.0147 0.0832 0.3184
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0013 0.0015 0.0015
Plasmodium vivax importin-beta 2, putative 0.0028 0.0109 0.1159
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0072 0.0846
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0136 0.0521
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0077 0.0548
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.008 0.0844
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0097 0.0692
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0072 0.0512
Leishmania major cathepsin L-like protease 0.0017 0.0038 0.0331
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.006 0.006
Echinococcus granulosus hyperpolarization activated cyclic 0.0014 0.0023 0.0023
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.006 0.006
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0072 0.0763
Echinococcus multilocularis RUN 0.002 0.0058 0.0058
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0064 0.0749
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.006 0.006
Trypanosoma brucei hypothetical protein, conserved 0.0147 0.0832 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0011 0.0041
Trichomonas vaginalis helicase, putative 0.0026 0.0097 0.0692
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0147 0.0832 0.3188
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0097 0.0692
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0019 0.0052 0.0052
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0013 0.0015 0.0015
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0038 0.0041
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0037 0.0162 0.0162
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0127 0.0127
Toxoplasma gondii PHD-finger domain-containing protein 0.0058 0.0288 0.2136
Loa Loa (eye worm) hypothetical protein 0.0044 0.0204 0.0781
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0056 0.0278 0.0278
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0011 0.0109
Loa Loa (eye worm) hypothetical protein 0.0147 0.0832 0.3188
Toxoplasma gondii histone lysine methyltransferase SET1 0.0227 0.1317 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0049 0.0232 0.2773
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0049 0.0232 0.2694
Echinococcus multilocularis voltage gated potassium channel 0.0014 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0147 0.0832 0.3188
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0248 0.1442 0.1442
Leishmania major cathepsin L-like protease 0.0064 0.0323 0.38
Echinococcus multilocularis microtubule associated protein 2 0.136 0.8197 0.8197
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0038 0.0264
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0232 0.2773
Leishmania major phosphatidylinositol 3-kinase, putative 0.0019 0.0052 0.0503
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.006 0.006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0052 0.0367
Schistosoma mansoni ran 0.0021 0.0064 0.0064
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0131 0.0131
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0323 0.3813
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0037 0.0162 0.0162
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0052 0.0367
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0019 0.0052 0.0503
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0013 0.0015 0.0776
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0234 0.0234
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0013 0.0015 0.0015
Loa Loa (eye worm) glutathione reductase 0.014 0.0789 0.3023
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0014 0.0023 0.0023
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0038 0.0041
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0136 0.0521
Schistosoma mansoni rab6-interacting 0.002 0.0058 0.0058
Mycobacterium ulcerans hypothetical protein 0.0147 0.0832 1
Leishmania major hypothetical protein, conserved 0.0019 0.005 0.048
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0182 0.1044 0.4004
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.0089
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0038 0.0038
Toxoplasma gondii target of rapamycin (TOR), putative 0.0019 0.0052 0.0328
Trichomonas vaginalis glutathione reductase, putative 0.0049 0.0232 0.1678
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0014 0.0023 0.0089
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.008 0.0115
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0013 0.0015 0.0044
Loa Loa (eye worm) CXXC zinc finger family protein 0.0116 0.0643 0.2465
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.0208 0.1504
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0002 0.0002
Echinococcus multilocularis FTZ F1 alpha 0.002 0.006 0.006
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0011 0.0066
Loa Loa (eye worm) PHD-finger family protein 0.0058 0.0288 0.1106
Brugia malayi RNA, U transporter 1 0.0081 0.0428 0.1643
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.005 0.0192
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0013 0.0015 0.0096
Schistosoma mansoni jumonji domain containing protein 0.0151 0.0852 0.0852
Brugia malayi PHD-finger family protein 0.0027 0.0103 0.0396
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0013 0.0015 0.0015
Toxoplasma gondii aldehyde dehydrogenase 0.0126 0.0704 0.5308
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0323 0.3813
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.0675 0.2588
Schistosoma mansoni nuclear hormone receptor 0.002 0.006 0.006
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0013 0.0015 0.0057
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0013 0.0015 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0097 0.0692
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0038 0.0264
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0019 0.0052 0.0522
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0052 0.0199
Brugia malayi ecdysteroid receptor 0.002 0.006 0.0231
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0058 0.0288 0.0288
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0038 0.0264
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.006 0.006
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0049 0.0232 0.2803
Brugia malayi MH2 domain containing protein 0.0122 0.0675 0.2588
Echinococcus granulosus histone acetyltransferase KAT2B 0.014 0.0786 0.0786
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.006 0.0225
Brugia malayi CXXC zinc finger family protein 0.0116 0.0643 0.2465
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0019 0.0052 0.0052
Loa Loa (eye worm) fibroinase 0.0017 0.0038 0.0145
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0049 0.0232 0.1702
Loa Loa (eye worm) hypothetical protein 0.0053 0.0257 0.0984
Echinococcus granulosus peregrin 0.0064 0.0324 0.0324
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0052 0.0367
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0024 0.008 0.0307
Trypanosoma cruzi cruzipain precursor, putative 0.0064 0.0323 0.3868
Loa Loa (eye worm) hypothetical protein 0.002 0.006 0.0231
Echinococcus multilocularis peregrin 0.0064 0.0324 0.0324
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0146 0.0825 0.0825
Leishmania major cathepsin L-like protease 0.0017 0.0038 0.0331
Giardia lamblia Sgs1 DNA helicase, putative 0.0017 0.0041 0.0958
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0019 0.005 0.0499
Brugia malayi Cathepsin L-like cysteine proteinase 0.0011 0.0004 0.0016
Loa Loa (eye worm) hypothetical protein 0.0018 0.0044 0.0167
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0028 0.0108 0.1138
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.005 0.005
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0109 0.1221
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0323 0.3813
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0328 0.0328
Brugia malayi PHD-finger family protein 0.0035 0.0148 0.0569
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0013 0.0015 0.0015
Echinococcus granulosus JmjC domain containing protein 4 0.0019 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0016
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0052 0.0199
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0007
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.003 0.0119 0.0119
Echinococcus multilocularis zinc finger protein 0.003 0.0116 0.0116
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0356 0.2097 0.3692
Loa Loa (eye worm) hypothetical protein 0.002 0.006 0.0231
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0014 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0024 0.008 0.0307
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0097 0.0692
Loa Loa (eye worm) hypothetical protein 0.002 0.0058 0.0224
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0013 0.0015 0.0057
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0069 0.0358 0.0358
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.006 0.006
Schistosoma mansoni bromodomain containing protein 0.0014 0.0024 0.0024
Echinococcus multilocularis cysteine protease 0.0017 0.0038 0.0038
Mycobacterium ulcerans ferredoxin reductase 0.0013 0.0015 0.0051
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0064 0.0749
Echinococcus granulosus intermediate filament protein 0.0053 0.0257 0.0257
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0064 0.0418
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.0073 0.0859
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0013 0.0015 0.0096
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0013 0.0015 0.0159
Entamoeba histolytica thioredoxin reductase, putative 0.0013 0.0015 0.0776
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0038 0.0297
Onchocerca volvulus 0.0017 0.0038 0.0139
Echinococcus multilocularis lysine specific demethylase 6a 0.0019 0.005 0.005
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0097 0.0692
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0072 0.0745
Loa Loa (eye worm) hypothetical protein 0.0104 0.0567 0.2172
Mycobacterium tuberculosis Conserved protein 0.0147 0.0832 0.1448
Schistosoma mansoni lamin 0.0053 0.0257 0.0257
Leishmania major hypothetical protein, conserved 0.0147 0.0832 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0038 0.0264
Plasmodium vivax hypothetical protein, conserved 0.0058 0.0288 0.335
Echinococcus multilocularis lamin dm0 0.0053 0.0257 0.0257
Echinococcus multilocularis JmjC domain containing protein 4 0.0019 0.005 0.005
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0136 0.0136
Brugia malayi intermediate filament protein 0.0053 0.0257 0.0984
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0052 0.0367
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.008 0.4595
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0323 0.3813
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.032 0.1881 0.3308
Schistosoma mansoni hypothetical protein 0.0071 0.0367 0.0367
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0031 0.0127 0.1506
Echinococcus multilocularis hyperpolarization activated cyclic 0.0014 0.0023 0.0023
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0064 0.0245
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0013 0.0015 0.0159
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0023 0.0023
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0038 0.0264
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.006 0.0231
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0058 0.0058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0052 0.0367
Schistosoma mansoni SET domain protein 0.0012 0.001 0.001
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0014 0.0023 0.0023
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0127 0.1412
Schistosoma mansoni glutamate synthase 0.0013 0.0015 0.0015
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0013 0.0015 0.0096
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0049 0.0232 0.0889
Loa Loa (eye worm) CYP4Cod1 0.0012 0.0011 0.0041
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0097 0.0692
Loa Loa (eye worm) hypothetical protein 0.0049 0.0234 0.0897
Schistosoma mansoni glutamate synthase 0.0013 0.0015 0.0015
Loa Loa (eye worm) RNA binding protein 0.0064 0.0328 0.1258
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0077 0.0905
Echinococcus multilocularis jumonji domain containing protein 0.0081 0.0426 0.0426
Onchocerca volvulus 0.0053 0.0257 0.0978
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0323 0.3868
Onchocerca volvulus 0.0017 0.0038 0.0139
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0025 0.0091 0.0091
Echinococcus granulosus GPCR family 2 0.0033 0.0136 0.0136
Entamoeba histolytica Ran family GTPase 0.0021 0.0064 0.3646
Echinococcus multilocularis serine protein kinase ATM 0.0026 0.0095 0.0095
Brugia malayi Pre-SET motif family protein 0.0032 0.0131 0.0502
Echinococcus granulosus lamin 0.0053 0.0257 0.0257
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.008 0.0844
Echinococcus multilocularis phd:f box containing protein 0.0019 0.005 0.005
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0025 0.0091 0.0091
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0044 0.133
Trichomonas vaginalis D-aminoacylase, putative 0.0147 0.0832 0.6051
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0019 0.0052 0.0607
Onchocerca volvulus 0.0237 0.1373 0.5262
Loa Loa (eye worm) beta-lactamase 0.0147 0.0832 0.3188
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0027 0.0102 0.0102
Mycobacterium ulcerans aldehyde dehydrogenase 0.0126 0.0704 0.8441
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0019 0.0052 0.0503
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0038 0.0264
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0049 0.0232 0.2708
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0064 0.0064
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0002 0.0002
Onchocerca volvulus 0.0017 0.0038 0.0139
Echinococcus multilocularis cpg binding protein 0.0125 0.0695 0.0695
Schistosoma mansoni aldehyde dehydrogenase 0.0126 0.0704 0.0704
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0056 0.0278 0.0278
Brugia malayi hypothetical protein 0.0011 0.0002 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.006 0.0231
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0208 0.1201 0.4603
Echinococcus multilocularis thioredoxin glutathione reductase 0.014 0.0789 0.0789
Plasmodium falciparum importin beta, putative 0.0028 0.0109 0.1223
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0026 0.0095 0.0095
Brugia malayi Cathepsin L-like precursor 0.0017 0.0038 0.0145
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0022 0.0151
Echinococcus granulosus lamin dm0 0.0053 0.0257 0.0257
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0049 0.0232 0.2773
Treponema pallidum NADH oxidase 0.0049 0.0232 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.0208 0.152
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0064 0.1789
Onchocerca volvulus 0.0147 0.0832 0.3184
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.006 0.0231
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0015 0.0159
Onchocerca volvulus 0.0053 0.0257 0.0978
Loa Loa (eye worm) hypothetical protein 0.0147 0.0832 0.3188
Entamoeba histolytica hypothetical protein 0.0023 0.0077 0.4406
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0153 0.0153
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0052 0.0367
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0106 0.0739
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0038 0.2123
Trichomonas vaginalis hypothetical protein 0.0014 0.0022 0.0151
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0127 0.0898
Giardia lamblia GTOR 0.0019 0.0052 0.1357
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0019 0.005 0.0314
Plasmodium vivax vivapain-2 0.0017 0.0038 0.0281
Loa Loa (eye worm) histone methyltransferase 0.0037 0.0162 0.062
Brugia malayi cytoplasmic intermediate filament protein 0.0028 0.0108 0.0414
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0109 0.1221
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0097 0.0692
Toxoplasma gondii selenide, water dikinase 0.0013 0.0015 0.0044
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0019 0.0052 0.0522
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0041 0.0245
Trypanosoma brucei NADH dehydrogenase 0.0013 0.0015 0.007
Loa Loa (eye worm) acetyltransferase 0.0146 0.0825 0.3163
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0014 0.0023 0.0089
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0013 0.0015 0.007
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0146 0.0825 0.0825
Leishmania major cathepsin L-like protease 0.0064 0.0323 0.38
Schistosoma mansoni hypothetical protein 0.0033 0.0136 0.0136
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0038 0.0264
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0026 0.0095 0.1127
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.0044 0.0044
Mycobacterium ulcerans aldehyde dehydrogenase 0.0126 0.0704 0.8441
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0022 0.0151
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0019 0.0052 0.0325
Brugia malayi Cathepsin L-like precursor 0.0011 0.0004 0.0016
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0097 0.0692
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0049 0.0232 0.2694
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0092 0.0494 0.5887
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.006 0.006
Onchocerca volvulus 0.0024 0.008 0.0301
Schistosoma mansoni polycystin 1-related 0.0075 0.0392 0.0392
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0052 0.0367
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0052 0.0367
Trichomonas vaginalis glutamate synthase, putative 0.0013 0.0015 0.0096
Loa Loa (eye worm) hypothetical protein 0.0018 0.0044 0.0167
Echinococcus multilocularis snurportin 1 0.0304 0.1784 0.1784
Plasmodium falciparum zinc finger protein, putative 0.0016 0.0031 0.0213
Echinococcus granulosus hyperpolarization activated cyclic 0.0014 0.0023 0.0023
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0013 0.0015 0.0096
Echinococcus granulosus snurportin 1 0.0304 0.1784 0.1784
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0097 0.0692
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0039 0.0039
Schistosoma mansoni jumonji/arid domain-containing protein 0.0079 0.0414 0.0414
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0038 0.0264
Loa Loa (eye worm) jmjC domain-containing protein 0.0079 0.0414 0.1588
Schistosoma mansoni ran 0.0021 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0017 0.0041 0.0157
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0323 0.3813
Trichomonas vaginalis mercuric reductase, putative 0.0049 0.0232 0.1678
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0126 0.0704 0.1221
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0097 0.0692
Echinococcus multilocularis GPCR, family 2 0.0033 0.0136 0.0136
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0323 0.3813
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.006 0.006
Schistosoma mansoni coup transcription factor 0.002 0.006 0.006
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0136 0.0521
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.006 0.0231
Leishmania major cathepsin L-like protease 0.0064 0.0323 0.38
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0097 0.0692
Mycobacterium ulcerans dehydrogenase 0.0013 0.0015 0.0051
Loa Loa (eye worm) hypothetical protein 0.0033 0.0139 0.0531
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0013 0.0015 0.0015
Echinococcus multilocularis lamin 0.0053 0.0257 0.0257
Trichomonas vaginalis DNA helicase recq1, putative 0.0042 0.019 0.1372
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.006 0.006
Plasmodium vivax JmjC domain containing protein 0.0019 0.005 0.0431
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0013 0.0015 0.0057
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.005 0.005
Mycobacterium ulcerans monoxygenase 0.0013 0.0015 0.0051
Loa Loa (eye worm) hypothetical protein 0.0052 0.0251 0.0961
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0052 0.0367
Brugia malayi Cathepsin L-like precursor 0.0011 0.0004 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0004 0.002
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0356 0.2097 0.3692
Toxoplasma gondii thioredoxin reductase 0.014 0.0789 0.5959
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0011 0.0041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0052 0.0367
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0328 0.1258
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0014 0.0023 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.006 0.0231
Brugia malayi hypothetical protein 0.002 0.0058 0.0224
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0104 0.0567 0.2172
Loa Loa (eye worm) hypothetical protein 0.0014 0.0024 0.0092
Echinococcus multilocularis jumonji domain containing 1A 0.0019 0.005 0.005
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0014 0.0023 0.0157
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0077 0.0548
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0328 0.0328
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0049 0.0232 0.2694
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0131 0.0932
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0038 0.0139
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0092 0.0494 0.0494
Brugia malayi TAR-binding protein 0.0064 0.0328 0.1258
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0109 0.0109
Trichomonas vaginalis DNA helicase recq, putative 0.0042 0.019 0.1372
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0052 0.0199
Schistosoma mansoni myst-related protein 0.0016 0.0031 0.0031
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.019 0.1089 0.1089
Plasmodium vivax SET domain protein, putative 0.0032 0.0131 0.1423
Trypanosoma brucei ISWI complex protein 0.0015 0.0029 0.024
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0039 0.0039
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0052 0.0516
Echinococcus granulosus bloom syndrome protein 0.0042 0.019 0.019
Schistosoma mansoni thyroid hormone receptor 0.002 0.006 0.006
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0061 0.0234
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0097 0.0692
Leishmania major hypothetical protein, conserved 0.0013 0.0015 0.0051
Loa Loa (eye worm) ctsf protein 0.0017 0.0038 0.0145
Echinococcus granulosus geminin 0.0676 0.4042 0.4042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0052 0.0367
Loa Loa (eye worm) hypothetical protein 0.0033 0.0136 0.0521
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0031 0.0127 0.1429
Brugia malayi hypothetical protein 0.0121 0.0671 0.2572
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.008 0.0313
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0023 0.0023
Brugia malayi isocitrate dehydrogenase 0.0031 0.0127 0.0485
Toxoplasma gondii PHD-finger domain-containing protein 0.0058 0.0288 0.2136
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.0208 0.1504
Loa Loa (eye worm) hypothetical protein 0.0018 0.0044 0.0167
Schistosoma mansoni zinc finger protein 0.003 0.0116 0.0116
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0011 0.0066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0038 0.0264
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.006 0.0231
Loa Loa (eye worm) hypothetical protein 0.0025 0.0091 0.0349
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.006 0.0231
Brugia malayi Cytochrome P450 family protein 0.0012 0.0011 0.0041
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.006 0.006
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0011 0.0066
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.008 0.0313
Leishmania major NADH dehydrogenase, putative 0.0013 0.0015 0.0051
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0041 0.0157
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0049 0.0232 0.2773
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0019 0.0052 0.0503
Onchocerca volvulus 0.0017 0.0038 0.0139
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0095 0.0515 0.1974
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0013 0.0015 0.0096
Brugia malayi hypothetical protein 0.002 0.0058 0.0224
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0013 0.0015 0.0051
Brugia malayi Calcitonin receptor-like protein seb-1 0.0104 0.0567 0.2172
Loa Loa (eye worm) hypothetical protein 0.0024 0.008 0.0307
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0176 0.1008 0.3861
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0172 1
Mycobacterium tuberculosis Conserved protein 0.0147 0.0832 0.1448
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0011 0.0109
Echinococcus granulosus cathepsin l1 0.0017 0.0038 0.0038
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0049 0.0232 0.2656
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0515 0.0515
Trypanosoma brucei ISWI complex protein 0.0012 0.0011 0.0019
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0027 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0035
Brugia malayi AMP-binding enzyme family protein 0.0024 0.008 0.0307
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.0015 0.007
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0019 0.0052 0.0607
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0013 0.0015 0.0044
Brugia malayi jmjC domain containing protein 0.0019 0.005 0.0192
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0049 0.0232 0.2708
Schistosoma mansoni hypothetical protein 0.0013 0.0015 0.0015
Brugia malayi PHD-finger family protein 0.0058 0.0288 0.1106
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0147 0.0832 0.1448
Echinococcus multilocularis isocitrate dehydrogenase 0.0031 0.0127 0.0127
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0019 0.0052 0.2953
Brugia malayi Cathepsin L-like precursor 0.0017 0.0038 0.0145
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0049 0.0234 0.0234
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0009 0.0054
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0006
Loa Loa (eye worm) hypothetical protein 0.0014 0.0023 0.0089
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0515 0.0515
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.005 0.0192
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.008 0.0844
Echinococcus multilocularis hyperpolarization activated cyclic 0.0014 0.0023 0.0023
Trypanosoma brucei cytochrome P450, putative 0.0012 0.0011 0.002
Loa Loa (eye worm) cysteine protease 0.0017 0.0038 0.0145
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0019 0.0052 0.2953
Mycobacterium ulcerans esterase/lipase LipP 0.0147 0.0832 1
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0013 0.0015 0.0776
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.024 0.2872
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0058 0.0564
Echinococcus granulosus sodium channel protein 0.0092 0.0494 0.0494
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0038 0.0264
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0053 0.0257 0.0984
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0049 0.0232 0.0584
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0014 0.0023 0.0023
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0038 0.0145
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0038 0.0264
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0038 0.0264
Schistosoma mansoni fkbp-rapamycin associated protein 0.0011 0.0002 0.0002
Mycobacterium tuberculosis Putative ferredoxin reductase 0.032 0.1881 0.3308
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0013 0.0015 0.0051
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0013 0.0015 0.0044
Mycobacterium ulcerans hypothetical protein 0.0024 0.008 0.0844
Mycobacterium tuberculosis Conserved protein 0.0147 0.0832 0.1448
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.008 0.0844
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.006 0.006
Schistosoma mansoni cpg binding protein 0.0116 0.0643 0.0643
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0064 0.0599
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0049 0.0232 0.2803
Brugia malayi Thioredoxin reductase 0.014 0.0789 0.3023
Schistosoma mansoni sulfide quinone reductase 0.0013 0.0015 0.0015
Mycobacterium tuberculosis Probable oxidoreductase 0.0356 0.2097 0.3692
Schistosoma mansoni hypothetical protein 0.0015 0.0029 0.0029
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0049 0.0232 0.2694
Loa Loa (eye worm) hypothetical protein 0.0176 0.1008 0.3865
Brugia malayi Cathepsin L-like precursor 0.0017 0.0038 0.0145
Brugia malayi hypothetical protein 0.044 0.2609 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0058 0.0224
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.008 0.0844
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0038 0.0264
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0014 0.0023 0.0023
Trypanosoma cruzi trypanothione reductase, putative 0.014 0.0789 0.9484
Brugia malayi Cytochrome P450 family protein 0.0012 0.0011 0.0041
Echinococcus granulosus FTZ F1 alpha 0.002 0.006 0.006
Brugia malayi SET domain containing protein 0.0012 0.001 0.0039
Mycobacterium ulcerans hypothetical protein 0.0013 0.0015 0.0051
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0126 0.0704 0.0704
Brugia malayi nuclear receptor RXR 0.0011 0.0002 0.0007
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0031 0.0127 0.0127
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0136 0.0136
Brugia malayi Cathepsin L-like precursor 0.0017 0.0038 0.0145
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0036 0.0153 0.0588
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0049 0.0234 0.0234
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0052 0.0367
Schistosoma mansoni glutamate synthase 0.0013 0.0015 0.0015
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0049 0.0232 0.2773
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0049 0.0232 0.2708
Schistosoma mansoni hypothetical protein 0.1657 1 1
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0127 0.0898
Leishmania major phosphatidylinositol kinase related protein, putative 0.0019 0.0052 0.0506
Trichomonas vaginalis esterase, putative 0.0147 0.0832 0.6051
Plasmodium vivax hypothetical protein, conserved 0.0026 0.0095 0.0976
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0064 0.0064
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0019 0.0052 0.0503
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0147 0.0832 0.1448
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.005 0.0584
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0016
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0019 0.0052 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0095 0.0682
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0007
Leishmania major cathepsin L-like protease 0.0017 0.0038 0.0331
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0014 0.0023 0.0023
Onchocerca volvulus 0.044 0.2609 1
Schistosoma mansoni lozenge 0.0055 0.0272 0.0272
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0127 0.0127
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0323 0.3813
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0058 0.0289 0.3464
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.006 0.006
Giardia lamblia NADH oxidase lateral transfer candidate 0.0049 0.0232 0.7928
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0019 0.0052 0.061
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0097 0.0692
Schistosoma mansoni aldehyde dehydrogenase 0.0126 0.0704 0.0704
Mycobacterium ulcerans NADH dehydrogenase 0.0013 0.0015 0.0051
Trichomonas vaginalis D-aminoacylase, putative 0.0147 0.0832 0.6051
Leishmania major trypanothione reductase 0.014 0.0789 0.9478
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0038 0.0038
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0147 0.0832 0.0832
Schistosoma mansoni hypothetical protein 0.0033 0.0136 0.0136
Brugia malayi N-terminal motif family protein 0.0176 0.1008 0.3865
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.006 0.006
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0013 0.0015 0.0096
Schistosoma mansoni hypothetical protein 0.0304 0.1784 0.1784
Echinococcus granulosus serine protein kinase ATM 0.0026 0.0095 0.0095
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0064 0.0247
Schistosoma mansoni hypothetical protein 0.0058 0.0288 0.0288
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0019 0.0052 0.0052
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0064 0.0633
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0044 0.0373
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.003 0.0119 0.0119
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0052 0.0367
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0013 0.0015 0.0159
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0007
Schistosoma mansoni importin beta-1 0.0028 0.0109 0.0109
Mycobacterium tuberculosis Probable esterase LipL 0.0147 0.0832 0.1448
Loa Loa (eye worm) hypothetical protein 0.0019 0.005 0.0192
Schistosoma mansoni loxhd1 0.002 0.0058 0.0058
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0014 0.0023 0.0023
Mycobacterium ulcerans glutamate synthase subunit beta 0.0013 0.0015 0.0051
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0013 0.0015 0.0015
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0038 0.0264
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0052 0.0367
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.006 0.0231
Entamoeba histolytica disulphide oxidoreductase, putative 0.0013 0.0015 0.0776
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.006 0.0231
Schistosoma mansoni rab6-interacting 0.002 0.0058 0.0058
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0013 0.0015 0.0057
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0019 0.0052 0.0052
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0017 0.0038 0.0145
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.006 0.0231
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0038 0.0038
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0014 0.0023 0.0089
Entamoeba histolytica cysteine proteinase, putative 0.0011 0.0004 0.0158
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0013 0.0015 0.0096
Plasmodium falciparum glutathione reductase 0.0049 0.0232 0.2803
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.006 0.0231
Loa Loa (eye worm) hypothetical protein 0.0058 0.0288 0.1106
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.006 0.0231
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0328 0.1258
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0058 0.0058
Schistosoma mansoni disulfide oxidoreductase 0.0013 0.0015 0.0015
Onchocerca volvulus 0.0012 0.001 0.0033
Brugia malayi Importin beta-1 subunit 0.0028 0.0109 0.042
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0014 0.0023 0.0157
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.006 0.0231
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0013 0.0015 0.0776
Echinococcus granulosus fetal alzheimer antigen falz 0.0029 0.0113 0.0113
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0013 0.0015 0.0051
Echinococcus granulosus importin subunit beta 1 0.0028 0.0109 0.0109
Toxoplasma gondii cathepsin CPL 0.0017 0.0038 0.022
Echinococcus granulosus histone lysine methyltransferase setb 0.0049 0.0234 0.0234
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0049 0.0232 0.0584
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0136 0.0136
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0031 0.0127 0.0198
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0038 0.0264
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0019 0.005 0.0314
Echinococcus granulosus phd:f box containing protein 0.0019 0.005 0.005
Echinococcus granulosus cpg binding protein 0.0125 0.0695 0.0695
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0014 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0024 0.0085 0.0326
Echinococcus multilocularis glutamate synthase 0.0013 0.0015 0.0015
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.006 0.006
Onchocerca volvulus Alhambra homolog 0.0058 0.0288 0.11
Schistosoma mansoni intermediate filament proteins 0.0053 0.0257 0.0257
Loa Loa (eye worm) programmed cell death 8 0.0013 0.0015 0.0057
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0049 0.0232 1
Brugia malayi Cathepsin L-like precursor 0.0017 0.0038 0.0145
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0328 0.0328
Brugia malayi glutamate synthase 0.0013 0.0015 0.0057
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0058 0.0058
Echinococcus multilocularis PHD finger protein rhinoceros 0.0058 0.0288 0.0288
Trypanosoma cruzi ISWI complex protein 0.0015 0.0029 0.0327
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0002 0.0007
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0038 0.0331
Echinococcus multilocularis geminin 0.0676 0.4042 0.4042
Brugia malayi Steroid receptor seven-up type 2 0.002 0.006 0.0231
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0041 0.0157
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0049 0.0232 0.2694
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0172 0.575
Leishmania major cathepsin L-like protease 0.0017 0.0038 0.0331
Loa Loa (eye worm) hypothetical protein 0.0315 0.185 0.7093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0052 0.0367
Brugia malayi jmjC domain containing protein 0.0019 0.005 0.0192
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0058 0.0058
Loa Loa (eye worm) doublecortin family protein 0.002 0.0058 0.0224
Echinococcus multilocularis dnaJ subfamily B 0.1657 1 1
Echinococcus granulosus cathepsin l1 0.0011 0.0004 0.0004
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0038 0.0264
Loa Loa (eye worm) hypothetical protein 0.0027 0.0103 0.0396
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0323 0.3813
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.005 0.0584
Toxoplasma gondii FATC domain-containing protein 0.0026 0.0095 0.0658
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0038 0.0038
Leishmania major GTP-binding protein, putative 0.0021 0.0064 0.0647
Toxoplasma gondii ABC1 family protein 0.0147 0.0832 0.6287
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0023 0.0023
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0031 0.0127 0.0127
Trichomonas vaginalis conserved hypothetical protein 0.0172 0.0981 0.7139
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0013 0.0015 0.0044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0052 0.0367
Loa Loa (eye worm) hypothetical protein 0.002 0.006 0.0231
Leishmania major hypothetical protein, conserved 0.0013 0.0015 0.0051
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0049 0.0232 0.2773
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0004 0.002
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.014 0.0789 0.1372
Entamoeba histolytica cysteine protease, putative 0.0017 0.0038 0.2123
Plasmodium falciparum thioredoxin reductase 0.0049 0.0232 0.2803
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0064 0.0245
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.032 0.1881 0.8958
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.006 0.0231
Brugia malayi cathepsin L-like precursor 0.0011 0.0004 0.0016
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0029 0.0113 0.0113
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0038 0.0038
Schistosoma mansoni lipoxygenase 0.0056 0.0278 0.0278
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0029 0.0113 0.0113
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0095 0.0515 0.1974
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0172 0.2033
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0038 0.2123
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0013 0.0015 0.0015
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0013 0.0015 0.007
Brugia malayi AMP-binding enzyme family protein 0.0024 0.008 0.0307
Trypanosoma cruzi NADH dehydrogenase, putative 0.0013 0.0015 0.0159
Schistosoma mansoni hypothetical protein 0.0676 0.4042 0.4042
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0356 0.2097 1
Onchocerca volvulus 0.0147 0.0832 0.3184
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.0004 0.0004
Mycobacterium leprae conserved hypothetical protein 0.0147 0.0832 0.3922
Brugia malayi jmjC domain containing protein 0.0019 0.005 0.0192
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0013 0.0015 0.0776
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.006 0.006
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0147 0.0832 0.0832
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.0367 0.1408
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.006 0.006
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0019 0.0052 0.0522
Mycobacterium ulcerans aldehyde dehydrogenase 0.0126 0.0704 0.8441
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.006 0.0225
Brugia malayi Bromodomain containing protein 0.0064 0.0324 0.1243
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0049 0.0232 0.2694
Onchocerca volvulus 0.0017 0.0038 0.0139
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0049 0.0232 0.0232
Brugia malayi Intermediate filament tail domain containing protein 0.0053 0.0257 0.0984
Brugia malayi jmjC domain containing protein 0.019 0.1089 0.4176
Plasmodium falciparum phd finger protein, putative 0.0058 0.0288 0.3536
Loa Loa (eye worm) jmjC domain-containing protein 0.012 0.0663 0.2543
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0109 0.0768
Brugia malayi glutathione reductase 0.014 0.0789 0.3023
Brugia malayi Pre-SET motif family protein 0.0208 0.1201 0.4603
Schistosoma mansoni hypothetical protein 0.0033 0.0136 0.0136
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0013 0.0015 0.0015
Echinococcus multilocularis musashi 0.0053 0.0257 0.0257
Brugia malayi jmjC domain containing protein 0.0079 0.0414 0.1588
Leishmania major importin beta-1 subunit, putative 0.0023 0.0077 0.0805
Trichomonas vaginalis apoptosis inducing factor, putative 0.0013 0.0015 0.0096
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0127 0.0127
Schistosoma mansoni thyroid hormone receptor 0.002 0.006 0.006
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0328 0.0328
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0013 0.0015 0.0051
Plasmodium falciparum thioredoxin reductase 0.014 0.0789 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.019 0.1089 0.1089
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0147 0.0832 0.3188
Entamoeba histolytica hypothetical protein 0.0016 0.0031 0.1743
Loa Loa (eye worm) RecQ helicase 0.0042 0.019 0.0728
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0515 0.0515
Loa Loa (eye worm) hypothetical protein 0.0053 0.0255 0.0979
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0017 0.0041 0.0041
Giardia lamblia PHD finger protein 15 0.0058 0.0288 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0044 0.0051
Brugia malayi beta-lactamase family protein 0.0147 0.0832 0.3188
Leishmania major cathepsin L-like protease 0.0017 0.0038 0.0331
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0011 0.0002 0.0002
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0013 0.0015 0.0096
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.0208 0.152
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0328 0.1258
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0039 0.0039
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.006 0.006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0323 0.3813
Brugia malayi Bromodomain containing protein 0.0085 0.0451 0.1727
Trichomonas vaginalis glutamate synthase, putative 0.0013 0.0015 0.0096
Loa Loa (eye worm) intermediate filament protein 0.0053 0.0257 0.0984
Schistosoma mansoni lamin 0.0053 0.0257 0.0257
Schistosoma mansoni jumonji domain containing protein 0.0019 0.005 0.005
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0038 0.0041
Schistosoma mansoni cpg binding protein 0.0125 0.0695 0.0695
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0002 0.0007
Echinococcus multilocularis bloom syndrome protein 0.0042 0.019 0.019
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0052 0.0516
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0038 0.0139
Schistosoma mansoni DNA helicase recq5 0.0017 0.0041 0.0041
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0037 0.0159 0.1864
Echinococcus granulosus thioredoxin glutathione reductase 0.014 0.0789 0.0789
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0044 0.0402
Loa Loa (eye worm) hypothetical protein 0.002 0.006 0.0231
Plasmodium vivax thioredoxin reductase, putative 0.014 0.0789 0.9475
Echinococcus granulosus RUN 0.002 0.0058 0.0058
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0019 0.0052 0.0522
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0049 0.0232 0.2656
Schistosoma mansoni DNA helicase recq1 0.0017 0.0041 0.0041
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0038 0.0264
Trichomonas vaginalis penicillin-binding protein, putative 0.0147 0.0832 0.6051
Loa Loa (eye worm) hypothetical protein 0.0071 0.0367 0.1408
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0038 0.0038
Trichomonas vaginalis penicillin-binding protein, putative 0.0147 0.0832 0.6051
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0014 0.0023 0.0023
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0031 0.0127 0.0127
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0131 0.0131
Wolbachia endosymbiont of Brugia malayi extracellular metallopeptidase 0.0624 0.3728 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0049 0.0232 0.0232
Loa Loa (eye worm) hypothetical protein 0.0147 0.0832 0.3188
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.032 0.1881 0.3308
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0014 0.0023 0.0023
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.0208 0.2364
Mycobacterium tuberculosis Probable lipase LipE 0.0147 0.0832 0.1448
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0013 0.0015 0.0096
Brugia malayi RNA binding protein 0.0064 0.0328 0.1258
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0031 0.0127 0.1368
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0036 0.0153 0.0588
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0126 0.0704 0.8441
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0038 0.0264
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0038 0.0264
Loa Loa (eye worm) hypothetical protein 0.0182 0.1044 0.4004
Plasmodium vivax hypothetical protein, conserved 0.0147 0.0832 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.008 0.4595
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0069 0.0358 0.0358
Brugia malayi jmjC domain containing protein 0.0019 0.005 0.0192
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0515 0.0515
Loa Loa (eye worm) hypothetical protein 0.0147 0.0832 0.3188
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.0208 0.0208
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0013 0.0015 0.0044
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0126 0.0704 0.0704
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0234 0.0234
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0017 0.0041 0.0041
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.006 0.0231
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.008 0.0844
Echinococcus granulosus lysine specific demethylase 5A 0.0079 0.0414 0.0414
Brugia malayi steroid hormone receptor 0.002 0.006 0.0231
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0013 0.0015 0.0051
Trypanosoma cruzi hypothetical protein, conserved 0.0147 0.0832 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.054 0.207
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0014 0.0023 0.0023
Echinococcus multilocularis beta LACTamase domain containing family member 0.0147 0.0832 0.0832
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0038 0.0168 0.0644
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0011 0.0002 0.0002
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0014 0.0023 0.0089
Echinococcus multilocularis sodium channel protein 0.0092 0.0494 0.0494
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0028 0.0108 0.0414
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.006 0.0231
Schistosoma mansoni bromodomain containing protein 0.0073 0.038 0.038
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0013 0.0015 0.007
Brugia malayi nuclear receptor NHR-88 0.002 0.006 0.0231
Entamoeba histolytica hypothetical protein 0.0026 0.0095 0.5483
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0019 0.0052 0.0607
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0023 0.0023
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0127 0.1506
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.008 0.0844
Echinococcus granulosus zinc finger protein 0.003 0.0116 0.0116
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0052 0.0367
Echinococcus granulosus voltage gated potassium channel 0.0014 0.0023 0.0023
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0038 0.0297
Loa Loa (eye worm) runx1 0.0055 0.0272 0.1041
Schistosoma mansoni phd/f-box containing protein 0.0019 0.005 0.005
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0097 0.0692
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0011 0.0002 0.0006
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0044 0.0353
Loa Loa (eye worm) hypothetical protein 0.0022 0.0073 0.0279
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.006 0.006
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0049 0.0232 0.0385
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0013 0.0015 0.0776
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0147 0.0832 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.008 0.0844
Echinococcus granulosus microtubule associated protein 2 0.136 0.8197 0.8197
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0013 0.0015 0.0051
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.006 0.0231
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0038 0.0038
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0015 0.0159
Brugia malayi Cyclic-nucleotide gated cation channel 0.0014 0.0023 0.0089
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.006 0.0231
Onchocerca volvulus 0.0017 0.0038 0.0139
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0052 0.0367
Loa Loa (eye worm) hypothetical protein 0.044 0.2609 1
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0013 0.0015 0.0051
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0019 0.0052 0.0522
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0104 0.0567 0.2172
Schistosoma mansoni myst-related protein 0.0016 0.0031 0.0031
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.002 0.006 0.0231
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0031 0.0127 0.1444
Loa Loa (eye worm) hypothetical protein 0.0147 0.0832 0.3188
Loa Loa (eye worm) hypothetical protein 0.0028 0.0109 0.042
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0049 0.0232 0.2708
Brugia malayi acetyltransferase, GNAT family protein 0.0146 0.0825 0.3163
Plasmodium vivax glutathione reductase, putative 0.014 0.0789 0.9475
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0049 0.0232 0.2773
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0009 0.0054
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.032 0.1881 0.3308
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.008 0.0115
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0147 0.0832 0.1448
Echinococcus multilocularis lysine specific demethylase 5A 0.007 0.0363 0.0363
Mycobacterium tuberculosis Probable dehydrogenase 0.032 0.1881 0.3308
Schistosoma mansoni hypothetical protein 0.0019 0.0052 0.0052
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.006 0.006
Brugia malayi Isocitrate dehydrogenase 0.0031 0.0127 0.0485
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0052 0.0367
Schistosoma mansoni sulfide quinone reductase 0.0013 0.0015 0.0015
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0131 0.0131
Brugia malayi Bromodomain containing protein 0.0042 0.0189 0.0724
Schistosoma mansoni hypothetical protein 0.002 0.0058 0.0058
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.008 0.0844
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0017 0.0041 0.0041
Onchocerca volvulus 0.0013 0.0015 0.0051
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0013 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.002 0.006 0.0231
Brugia malayi hypothetical protein 0.0011 0.0002 0.0007
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0038 0.0264
Schistosoma mansoni cpg binding protein 0.0125 0.0695 0.0695
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0942 0.5655 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.006 0.0231
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0014 0.0023 0.0023
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0064 0.0666
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0007
Echinococcus granulosus PHD finger protein rhinoceros 0.0058 0.0288 0.0288
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0013 0.0015 0.0159
Schistosoma mansoni microtubule-associated protein tau 0.136 0.8197 0.8197
Brugia malayi AMP-binding enzyme family protein 0.0024 0.008 0.0307
Brugia malayi Cathepsin L-like precursor 0.0017 0.0038 0.0145
Loa Loa (eye worm) hypothetical protein 0.002 0.006 0.0231
Schistosoma mansoni protein phosphatase 2C 0.0019 0.005 0.005
Trichomonas vaginalis set domain proteins, putative 0.0237 0.1373 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.008 0.4595
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0052 0.0367
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0026 0.0095 0.0365
Echinococcus granulosus glutamate synthase 0.0013 0.0015 0.0015
Leishmania major hypothetical protein, conserved 0.0013 0.0015 0.0051
Trypanosoma brucei trypanothione reductase 0.014 0.0789 0.9479
Schistosoma mansoni blooms syndrome DNA helicase 0.0033 0.0137 0.0137
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0127 0.1429
Brugia malayi beta-lactamase 0.0147 0.0832 0.3188
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0052 0.0367
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0026 0.0095 0.1047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0052 0.0367
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0038 0.0264
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0013 0.0015 0.007
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0304 0.1784 0.6837
Loa Loa (eye worm) steroid hormone receptor 0.002 0.006 0.0231
Toxoplasma gondii NADPH-glutathione reductase 0.0049 0.0232 0.1702
Echinococcus multilocularis mixed lineage leukemia protein mll 0.003 0.0119 0.0119
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0017 0.0041 0.0339
Mycobacterium leprae Probable lipase LipE 0.0147 0.0832 0.3922
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0038 0.0297
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0038 0.0264
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0038 0.0264
Brugia malayi AF-10 protein 0.0019 0.0052 0.0197
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0058 0.0058
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.008 0.0844
Entamoeba histolytica recQ family helicase, putative 0.0022 0.0072 0.4116
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0017 0.0041 0.0041
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0323 0.3868
Trichomonas vaginalis ran, putative 0.0021 0.0064 0.0453
Schistosoma mansoni hypothetical protein 0.0033 0.0136 0.0136
Trypanosoma cruzi ISWI complex protein 0.0015 0.0029 0.0327
Brugia malayi F/Y-rich N-terminus family protein 0.0057 0.0285 0.1094
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0052 0.0367
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0039 0.0039
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0515 0.0515
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0014 0.0023 0.0089
Trichomonas vaginalis D-aminoacylase, putative 0.0147 0.0832 0.6051
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0077 0.0548
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0097 0.0692
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0002 0.0007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0323 0.3813
Echinococcus granulosus jumonji domain containing protein 0.0081 0.0426 0.0426
Echinococcus granulosus mixed lineage leukemia protein mll 0.003 0.0119 0.0119
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0052 0.0199
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0038 0.0145
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0038 0.0041
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0013 0.0015 0.0051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.006 0.0231
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0038 0.0264
Onchocerca volvulus 0.002 0.0058 0.0218
Echinococcus granulosus tar DNA binding protein 0.0064 0.0328 0.0328
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0018 0.0044 0.0167
Loa Loa (eye worm) hypothetical protein 0.044 0.2609 1
Mycobacterium tuberculosis Probable reductase 0.032 0.1881 0.3308
Loa Loa (eye worm) hypothetical protein 0.0013 0.0015 0.0057
Mycobacterium tuberculosis Probable lipase LipD 0.0147 0.0832 0.1448
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0014 0.0023 0.0023
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0041 0.0245
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0049 0.0232 0.0232
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0052 0.0367
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0049 0.0232 0.2773
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0013 0.0015 0.0159
Schistosoma mansoni voltage-gated potassium channel 0.0014 0.0023 0.0023
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.006 0.006
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0097 0.0692
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0515 0.0515
Plasmodium falciparum JmjC domain-containing protein, putative 0.0019 0.005 0.0455
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.005 0.0192
Schistosoma mansoni lipoxygenase 0.002 0.0058 0.0058

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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