Detailed information for compound 805949

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 298.312 | Formula: C17H15FN2O2
  • H donors: 1 H acceptors: 1 LogP: 2.96 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1cccc(c1)N1C(=O)NC2CC1(C)Oc1c2cccc1
  • InChi: 1S/C17H15FN2O2/c1-17-10-14(13-7-2-3-8-15(13)22-17)19-16(21)20(17)12-6-4-5-11(18)9-12/h2-9,14H,10H2,1H3,(H,19,21)
  • InChiKey: BQOHJBOIUGENCN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0305 0.0401 1
Echinococcus multilocularis 0.5562 0.8006 1
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0081 0.0077 0.1798
Brugia malayi transcriptional regulator, Sir2 family protein 0.045 0.0611 0.0602
Brugia malayi proprotein convertase 2 0.4382 0.63 0.6297
Plasmodium falciparum plasmepsin IX 0.0035 0.001 0.0112
Trypanosoma cruzi subtilisin peptidase 0.0305 0.0401 0.6388
Schistosoma mansoni hypothetical protein 0.0069 0.006 0.0056
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0131 0.0149 0.0145
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0053 0.0037 0.0702
Toxoplasma gondii subtilisin SUB11 0.0305 0.0401 0.8492
Mycobacterium ulcerans polyketide synthase Pks13 0.0081 0.0077 0.1727
Echinococcus multilocularis discoidin domain receptor 0.0042 0.0021 0.0021
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0052 0.0036 0.0752
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0057 0.0042 0.0831
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0057 0.0042 0.0831
Schistosoma mansoni dock 0.0042 0.0021 0.0017
Plasmodium vivax aspartyl proteinase, putative 0.0035 0.001 0.0112
Trichomonas vaginalis WD repeat domain, putative 0.0139 0.0161 0.0257
Mycobacterium leprae Probable polyketide synthase Pks1 0.0057 0.0042 0.0831
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0021 0.0028
Onchocerca volvulus 0.0035 0.001 0.0005
Brugia malayi hypothetical protein 0.0048 0.003 0.0021
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0622 0.086 0.086
Trypanosoma brucei SIR2-like protein 4, putative 0.0066 0.0056 0.0465
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0035 0.001 0.001
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0054 0.0039 0.0824
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0305 0.0401 0.0651
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0021 0.0028
Echinococcus multilocularis Coagulation factor 5 8 type, C terminal 0.0042 0.0021 0.0021
Onchocerca volvulus 0.0036 0.0013 0.0042
Schistosoma mansoni serine protease inhibitors serpins 0.0048 0.003 0.0026
Mycobacterium ulcerans thioesterase 0.0047 0.0027 0.0462
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0034 0.001 0.0006
Mycobacterium ulcerans NAD-dependent deacetylase 0.0066 0.0056 0.119
Loa Loa (eye worm) hypothetical protein 0.0494 0.0674 0.0674
Mycobacterium ulcerans Sir2-like regulatory protein 0.0066 0.0056 0.119
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0066 0.0056 0.0085
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0066 0.0056 0.0603
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0038 0.0015 0.0011
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0035 0.001 0.001
Brugia malayi SWIRM domain containing protein 0.0535 0.0735 0.0726
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.0042 0.002 0.0016
Schistosoma mansoni amine oxidase 0.01 0.0105 0.0101
Mycobacterium tuberculosis Conserved hypothetical protein 0.01 0.0105 0.251
Loa Loa (eye worm) hypothetical protein 0.0048 0.003 0.003
Schistosoma mansoni hypothetical protein 0.0055 0.0039 0.0035
Loa Loa (eye worm) hypothetical protein 0.0648 0.0897 0.0897
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0305 0.0401 0.0651
Mycobacterium tuberculosis Possible arabinofuranosyltransferase AftD 0.0042 0.0021 0.0379
Loa Loa (eye worm) hypothetical protein 0.0035 0.001 0.001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0305 0.0401 0.0651
Echinococcus multilocularis 0.01 0.0105 0.0126
Loa Loa (eye worm) hypothetical protein 0.0038 0.0015 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.1378 0.1954 0.3202
Echinococcus granulosus fibrillin 1 0.0127 0.0144 0.014
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0042 0.0021 0.0028
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.694 1 1
Loa Loa (eye worm) hypothetical protein 0.0305 0.0401 0.0401
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0305 0.0401 0.6388
Loa Loa (eye worm) apoptosis regulator protein 0.0055 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0048 0.0029 0.0029
Brugia malayi hypothetical protein 0.01 0.0105 0.0096
Loa Loa (eye worm) proprotein convertase 2 0.1683 0.2395 0.2395
Schistosoma mansoni c4b-binding protein beta chain 0.0035 0.001 0.0006
Schistosoma mansoni chromatin regulatory protein sir2 0.0066 0.0056 0.0052
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0035 0.001 0.019
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0042 0.0021 0.0297
Loa Loa (eye worm) serpin 0.0048 0.003 0.003
Echinococcus granulosus membrane bound transcription factor site 1 0.0305 0.0401 0.0397
Toxoplasma gondii aspartyl protease 0.0035 0.001 0.019
Trichomonas vaginalis conserved hypothetical protein 0.1378 0.1954 0.3202
Echinococcus multilocularis integrin alpha ps 0.0814 0.1138 0.1417
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0066 0.0056 0.0465
Schistosoma mansoni chromatin regulatory protein sir2 0.0066 0.0056 0.0052
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.001 0.0006
Brugia malayi hypothetical protein 0.0117 0.013 0.0121
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0048 0.0029 0.0144
Mycobacterium ulcerans monoamine oxidase 0.01 0.0105 0.2446
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0113 0.0124 0.0114
Onchocerca volvulus 0.0035 0.001 0.0007
Toxoplasma gondii subtilisin SUB2 0.0305 0.0401 0.8492
Brugia malayi serpin 0.0048 0.003 0.0021
Echinococcus granulosus subfamily M12B unassigned peptidase 0.009 0.009 0.0086
Brugia malayi hypothetical protein 0.0048 0.0029 0.0019
Giardia lamblia Neurogenic locus Notch protein precursor 0.0125 0.0141 0.0332
Loa Loa (eye worm) integrin beta-2 0.425 0.6108 0.6108
Mycobacterium ulcerans Type I modular polyketide synthase 0.0053 0.0037 0.0702
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0305 0.0401 0.0651
Toxoplasma gondii F5/8 type C domain-containing protein 0.0042 0.0021 0.0426
Echinococcus granulosus furin 0.694 1 1
Onchocerca volvulus 0.0139 0.0161 0.2088
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1683 0.2395 0.3925
Plasmodium falciparum plasmepsin I 0.0035 0.001 0.0112
Onchocerca volvulus 0.0535 0.0735 1
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.01 0.0105 0.0101
Giardia lamblia Transcriptional regulator, Sir2 family 0.0066 0.0056 0.0098
Toxoplasma gondii subtilisin SUB10 0.0305 0.0401 0.8492
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0035 0.001 0.001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.424 0.6095 1
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0066 0.0056 0.0856
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0021 0.0028
Brugia malayi EGF-like domain containing protein 0.0125 0.0141 0.0132
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0021 0.0028
Loa Loa (eye worm) hypothetical protein 0.0125 0.0141 0.0141
Schistosoma mansoni chromatin regulatory protein sir2 0.0066 0.0056 0.0052
Loa Loa (eye worm) hypothetical protein 0.0125 0.0141 0.0141
Loa Loa (eye worm) transcriptional regulator 0.0066 0.0056 0.0056
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0305 0.0401 1
Schistosoma mansoni serine protease inhibitors serpins 0.0048 0.003 0.0026
Onchocerca volvulus 0.0048 0.003 0.0284
Schistosoma mansoni serine protease inhibitors serpins 0.0048 0.003 0.0026
Toxoplasma gondii subtilisin SUB9 0.0305 0.0401 0.8492
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0305 0.0401 1
Schistosoma mansoni memapsin-2 (A01 family) 0.0035 0.001 0.0006
Toxoplasma gondii subtilisin SUB5 0.0305 0.0401 0.8492
Leishmania major UDP-galactopyranose mutase 0.01 0.0105 0.1665
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0126 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.0065 0.0054 0.0054
Echinococcus multilocularis serine protease inhibitor 0.0048 0.003 0.0033
Toxoplasma gondii protease inhibitor PI1 0.0048 0.003 0.0619
Plasmodium falciparum plasmepsin III 0.0035 0.001 0.0112
Brugia malayi serpin precursor 0.0048 0.003 0.0021
Brugia malayi Sex muscle abnormal protein 5 0.0126 0.0143 0.0133
Leishmania major silent information regulator 2, putative 0.045 0.0611 1
Plasmodium falciparum plasmepsin IV 0.0035 0.001 0.0112
Loa Loa (eye worm) transcriptional regulator 0.045 0.0611 0.0611
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0036 0.0013 0.0003
Plasmodium falciparum subtilisin-like protease 2 0.0305 0.0401 0.7663
Echinococcus granulosus protein kinase c epsilon type 0.0089 0.0089 0.0085
Onchocerca volvulus 0.0035 0.001 0.0007
Loa Loa (eye worm) hypothetical protein 0.0719 0.1001 0.1001
Giardia lamblia High cysteine protein 0.0125 0.0141 0.0332
Loa Loa (eye worm) hypothetical protein 0.0048 0.003 0.003
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0305 0.0401 0.0651
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.1378 0.1954 0.3202
Echinococcus granulosus C type lectin domian containing protein 0.0035 0.001 0.0006
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0305 0.0401 1
Loa Loa (eye worm) fatty acid synthase 0.0055 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0035 0.001 0.001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0305 0.0401 0.0651
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0305 0.0401 0.0651
Echinococcus granulosus adam 0.0243 0.0311 0.0307
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0066 0.0056 0.0085
Brugia malayi EGF-like domain containing protein 0.0125 0.0141 0.0132
Onchocerca volvulus 0.0048 0.003 0.0284
Plasmodium vivax subtilisin-like serine protease, putative 0.0305 0.0401 0.7663
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0052 0.0036 0.0036
Brugia malayi BmSERPIN, truncated 0.0048 0.003 0.0021
Brugia malayi serpin (BmSERPIN) 0.0048 0.003 0.0021
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0066 0.0056 0.0603
Echinococcus multilocularis protein will die slowly 0.0139 0.0161 0.0196
Echinococcus multilocularis integrin alpha ps 0.0749 0.1044 0.13
Loa Loa (eye worm) hypothetical protein 0.0069 0.006 0.006
Giardia lamblia Furin precursor putative serine protease 0.1378 0.1954 0.5313
Loa Loa (eye worm) hypothetical protein 0.27 0.3865 0.3865
Echinococcus granulosus neuroendocrine convertase 2 0.4382 0.63 0.6299
Loa Loa (eye worm) hypothetical protein 0.0048 0.003 0.003
Echinococcus multilocularis MAM 0.0069 0.006 0.0069
Loa Loa (eye worm) hypothetical protein 0.0066 0.0056 0.0056
Entamoeba histolytica serine protease inhibitor, putative 0.0048 0.003 0.0164
Onchocerca volvulus 0.0035 0.001 0.0007
Brugia malayi Integrin alpha pat-2 precursor 0.1469 0.2085 0.2077
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0057 0.0042 0.0909
Giardia lamblia hypothetical protein 0.0125 0.0141 0.0332
Plasmodium vivax protoporphyrinogen oxidase, putative 0.01 0.0105 0.1952
Schistosoma mansoni discoidin domain receptor 0.0042 0.0021 0.0017
Mycobacterium ulcerans protoporphyrinogen oxidase 0.01 0.0105 0.2446
Loa Loa (eye worm) hypothetical protein 0.0029 0.0001 0.0001
Toxoplasma gondii serpin (serine proteinase inhibitor) superfamily protein 0.0048 0.003 0.0619
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0305 0.0401 0.0651
Giardia lamblia Sirtuin type 2 0.0066 0.0056 0.0098
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0036 0.0013 0.0247
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.424 0.6095 0.6093
Brugia malayi ADAMTS-like protease 0.0052 0.0036 0.0026
Onchocerca volvulus Fatty acid synthase homolog 0.0101 0.0106 0.1332
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0053 0.0037 0.0782
Chlamydia trachomatis protoporphyrinogen oxidase 0.01 0.0105 0.5
Loa Loa (eye worm) hypothetical protein 0.0052 0.0036 0.0036
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0762 0.1062 0.1322
Schistosoma mansoni apoptosis regulator bax 0.0055 0.0039 0.0035
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.004 0.0018 0.0308
Schistosoma mansoni chromatin regulatory protein sir2 0.045 0.0611 0.0607
Mycobacterium leprae PROBABLE CONSERVED TRANSMEMBRANE PROTEIN 0.0042 0.0021 0.0295
Mycobacterium ulcerans polyketide synthase 0.0053 0.0037 0.0702
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.424 0.6095 0.7611
Trichomonas vaginalis conserved hypothetical protein 0.0305 0.0401 0.0651
Plasmodium falciparum plasmepsin VI 0.0035 0.001 0.0112
Giardia lamblia High cysteine protein 0.0125 0.0141 0.0332
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.033 0.0437 0.7009
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0089 0.0089 0.0089
Toxoplasma gondii aspartyl protease ASP3 0.0035 0.001 0.019
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0305 0.0401 1
Schistosoma mansoni septate junction protein 0.0051 0.0034 0.003
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0038 0.0015 0.0015
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0066 0.0056 0.1003
Schistosoma mansoni integrin alpha-ps 0.0749 0.1044 0.104
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.424 0.6095 1
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.01 0.0105 0.2446
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0038 0.0016 0.0012
Giardia lamblia Hypothetical protein 0.045 0.0611 0.1622
Onchocerca volvulus 0.0098 0.0101 0.1263
Loa Loa (eye worm) hypothetical protein 0.0035 0.001 0.001
Echinococcus multilocularis Estrogen regulated protein EP45 0.0048 0.003 0.0033
Toxoplasma gondii subtilisin SUB1 0.0305 0.0401 0.8492
Loa Loa (eye worm) hypothetical protein 0.0055 0.0039 0.0039
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.001 0.0006
Loa Loa (eye worm) sirtuin 4 0.0066 0.0056 0.0056
Schistosoma mansoni hypothetical protein 0.0055 0.0039 0.0035
Echinococcus granulosus disintegrin and metalloproteinase 0.0037 0.0014 0.001
Loa Loa (eye worm) TK/EGFR protein kinase 0.0403 0.0543 0.0543
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0305 0.0401 0.0651
Schistosoma mansoni furin-1 (S08 family) 0.3004 0.4306 0.4304
Schistosoma mansoni integrin beta subunit 0.2498 0.3573 0.3571
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.009 0.009 0.0086
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0021 0.0028
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0055 0.0039 0.003
Echinococcus granulosus chromatin regulatory protein sir2 0.045 0.0611 0.0607
Schistosoma mansoni serine protease inhibitors serpins 0.0048 0.003 0.0026
Toxoplasma gondii type I fatty acid synthase, putative 0.0057 0.0042 0.0871
Brugia malayi angiogenesis inhibito 0.0052 0.0036 0.0026
Toxoplasma gondii rhoptry neck protein RON9 0.0035 0.001 0.0192
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0021 0.0028
Toxoplasma gondii subtilisin SUB12 0.0305 0.0401 0.8492
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.009 0.009 0.0086
Echinococcus multilocularis growth factor receptor bound protein 2 0.0126 0.0143 0.0173
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0066 0.0056 0.0465
Loa Loa (eye worm) hypothetical protein 0.0535 0.0735 0.0735
Schistosoma mansoni chromatin regulatory protein sir2 0.045 0.0611 0.0607
Echinococcus granulosus discoidin domain receptor 0.0042 0.0021 0.0017
Schistosoma mansoni cathepsin D (A01 family) 0.0035 0.001 0.0006
Echinococcus multilocularis epidermal growth factor receptor 0.0403 0.0543 0.0673
Echinococcus granulosus discoidin domain containing receptor 2 0.0042 0.0021 0.0017
Toxoplasma gondii histone lysine-specific demethylase 0.01 0.0105 0.2213
Brugia malayi EGF-like domain containing protein 0.0125 0.0141 0.0132
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0021 0.0028
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0035 0.001 0.019
Schistosoma mansoni amine oxidase 0.01 0.0105 0.0101
Toxoplasma gondii histone arginine methyltransferase PRMT1 0.003 0.0004 0.0067
Brugia malayi protein kinase C II. 0.0089 0.0089 0.008
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0057 0.0042 0.0909
Brugia malayi Stress-activated protein kinase jnk-1 0.0762 0.1062 0.1053
Echinococcus multilocularis fibrillin 1 0.014 0.0163 0.0198
Toxoplasma gondii PA14 domain-containing protein 0.0042 0.0021 0.0426
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.01 0.0105 0.1952
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0053 0.0037 0.0027
Plasmodium falciparum plasmepsin X 0.0035 0.001 0.0112
Onchocerca volvulus 0.0048 0.003 0.0284
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0037 0.0014 0.0012
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0305 0.0401 0.0651
Echinococcus granulosus protein will die slowly 0.0139 0.0161 0.0157
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0305 0.0401 1
Echinococcus multilocularis integrin alpha ps 0.0359 0.048 0.0594
Schistosoma mansoni hypothetical protein 0.0069 0.006 0.0056
Loa Loa (eye worm) hypothetical protein 0.111 0.1565 0.1565
Trichomonas vaginalis conserved hypothetical protein 0.1378 0.1954 0.3202
Loa Loa (eye worm) hypothetical protein 0.0037 0.0014 0.0014
Loa Loa (eye worm) serpin 0.0048 0.003 0.003
Plasmodium vivax subtilisin-like protease 2, putative 0.0305 0.0401 0.7663
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0305 0.0401 1
Schistosoma mansoni protein kinase 0.0131 0.0149 0.0145
Echinococcus granulosus lysine specific histone demethylase 1A 0.01 0.0105 0.0101
Echinococcus multilocularis protoporphyrinogen oxidase 0.01 0.0105 0.0126
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0305 0.0401 0.0651
Echinococcus granulosus Coagulation factor 5 8 type C terminal 0.0042 0.0021 0.0017
Loa Loa (eye worm) hypothetical protein 0.0048 0.003 0.003
Schistosoma mansoni serine protease inhibitors serpins 0.0048 0.003 0.0026
Schistosoma mansoni protein kinase 0.0131 0.0149 0.0145
Brugia malayi hypothetical protein 0.0069 0.006 0.005
Loa Loa (eye worm) hypothetical protein 0.009 0.009 0.009
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0035 0.001 0.0007
Schistosoma mansoni hypothetical protein 0.0042 0.0021 0.0017
Onchocerca volvulus 0.0035 0.001 0.0007
Loa Loa (eye worm) hypothetical protein 0.0424 0.0574 0.0574
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0305 0.0401 0.0651
Mycobacterium leprae Possible secreted protease 0.0305 0.0401 1
Onchocerca volvulus 0.0305 0.0401 0.5394
Brugia malayi hypothetical protein 0.0048 0.003 0.0021
Mycobacterium ulcerans Type I modular polyketide synthase 0.0053 0.0037 0.0702
Toxoplasma gondii aspartyl protease ASP1 0.0035 0.001 0.019
Brugia malayi serpin 0.0048 0.003 0.0021
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0066 0.0056 0.0085
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0054 0.0039 0.0824
Onchocerca volvulus 0.0035 0.001 0.0007
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.045 0.0611 0.0758
Loa Loa (eye worm) hypothetical protein 0.0035 0.001 0.001
Brugia malayi AMP-binding enzyme family protein 0.0052 0.0036 0.0026
Trichomonas vaginalis beta-hexosaminidase B, putative 0.0042 0.0021 0.0028
Plasmodium falciparum plasmepsin V 0.0388 0.0521 1
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0305 0.0401 0.0397
Echinococcus multilocularis Tolloid protein 1 0.0038 0.0015 0.0014
Echinococcus granulosus adam 17 protease 0.0037 0.0014 0.001
Toxoplasma gondii rhoptry neck protein RON1 0.0035 0.001 0.0192
Giardia lamblia Tenascin-like 0.0125 0.0141 0.0332
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0021 0.0028
Schistosoma mansoni integrin alpha-ps 0.0455 0.0619 0.0615
Echinococcus granulosus serine protease inhibitor 0.0048 0.003 0.0026
Loa Loa (eye worm) serpin 0.0048 0.003 0.003
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0305 0.0401 1
Toxoplasma gondii hypothetical protein 0.0125 0.0141 0.2983
Plasmodium falciparum subtilisin-like protease 3 0.0305 0.0401 0.7663
Trichomonas vaginalis conserved hypothetical protein 0.0305 0.0401 0.0651
Echinococcus granulosus serine:threonine protein kinase N2 0.0073 0.0066 0.0062
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.045 0.0611 1
Echinococcus granulosus Estrogen regulated protein EP45 0.0048 0.003 0.0026
Plasmodium falciparum LCCL domain-containing protein 0.0042 0.0021 0.0327
Schistosoma mansoni serine protease inhibitors serpins 0.0048 0.003 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0021 0.0028
Onchocerca volvulus 0.0035 0.001 0.0005
Plasmodium falciparum apical sushi protein 0.0035 0.001 0.0114
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0021 0.0028
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0053 0.0037 0.0782
Trichomonas vaginalis conserved hypothetical protein 0.1378 0.1954 0.3202
Loa Loa (eye worm) serpin 0.0048 0.003 0.003
Plasmodium vivax hypothetical protein, conserved 0.0066 0.0056 0.1003
Trypanosoma cruzi UDP-galactopyranose mutase 0.01 0.0105 0.1309
Brugia malayi Kelch motif family protein 0.0673 0.0933 0.0924
Echinococcus multilocularis Furin 1 0.1683 0.2395 0.2987
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0305 0.0401 0.0496
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0038 0.0016 0.0012
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0305 0.0401 0.0651
Brugia malayi NAD-dependent deacetylase SIRT1 0.0066 0.0056 0.0047
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0042 0.0021 0.0028
Plasmodium vivax aspartyl protease, putative 0.0035 0.001 0.0112
Echinococcus granulosus Furin 1 0.1683 0.2395 0.2392
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0035 0.001 0.0006
Onchocerca volvulus 0.0035 0.001 0.0007
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0305 0.0401 0.0651
Echinococcus multilocularis serine protease inhibitor 0.0048 0.003 0.0033
Brugia malayi serpin 0.0048 0.003 0.0021
Loa Loa (eye worm) hypothetical protein 0.0034 0.0009 0.0009
Brugia malayi Subtilase family protein 0.0305 0.0401 0.0391
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0055 0.0039 0.0044
Onchocerca volvulus 0.0125 0.0141 0.1818
Plasmodium vivax subtilisin-like protease 1 0.0305 0.0401 0.7663
Giardia lamblia High cysteine membrane protein Group 2 0.2557 0.366 1
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0066 0.0056 0.0052
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0066 0.0056 0.0065
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0021 0.0028
Plasmodium vivax LCCL domain-containing protein 0.0042 0.0021 0.0327
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.001 0.0006
Echinococcus multilocularis disintegrin and metalloproteinase 0.0037 0.0014 0.0012
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.001 0.0006
Toxoplasma gondii F5/8 type C domain-containing protein 0.0042 0.0021 0.0426
Trichomonas vaginalis conserved hypothetical protein 0.0305 0.0401 0.0651
Trypanosoma cruzi UDP-galactopyranose mutase 0.01 0.0105 0.1309
Onchocerca volvulus 0.0048 0.003 0.0284
Onchocerca volvulus 0.0109 0.0118 0.1494
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0305 0.0401 0.0651
Echinococcus granulosus serine protease inhibitor 0.0048 0.003 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.1378 0.1954 0.3202
Brugia malayi SWIRM domain containing protein 0.0042 0.002 0.0011
Loa Loa (eye worm) hypothetical protein 0.0036 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.694 1 1
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0305 0.0401 0.0391
Plasmodium falciparum protoporphyrinogen oxidase 0.01 0.0105 0.1952
Echinococcus granulosus integrin beta 2 0.3145 0.451 0.4508
Loa Loa (eye worm) hypothetical protein 0.0125 0.0141 0.0141
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.001 0.0006
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.001 0.0006
Onchocerca volvulus 0.0042 0.0021 0.0159
Brugia malayi Serpin protein 6 0.0048 0.003 0.0021
Echinococcus granulosus c4b binding protein beta chain 0.0035 0.001 0.0006
Brugia malayi transcriptional regulator, Sir2 family protein 0.0066 0.0056 0.0047
Loa Loa (eye worm) hypothetical protein 0.0035 0.001 0.001
Plasmodium vivax apical sushi protein, putative 0.0035 0.001 0.0114
Loa Loa (eye worm) hypothetical protein 0.0455 0.0619 0.0619
Trichomonas vaginalis conserved hypothetical protein 0.1378 0.1954 0.3202
Brugia malayi transcriptional regulator, Sir2 family protein 0.0066 0.0056 0.0047
Schistosoma mansoni btb and poz domain-containing protein 0.0042 0.0021 0.0017
Schistosoma mansoni growth factor receptor-bound protein 0.0126 0.0143 0.0139
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0021 0.0028
Loa Loa (eye worm) hypothetical protein 0.0091 0.0092 0.0092
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.045 0.0611 0.0996
Loa Loa (eye worm) hypothetical protein 0.0035 0.001 0.001
Brugia malayi Reprolysin 0.0053 0.0036 0.0027
Loa Loa (eye worm) transcriptional regulator 0.0066 0.0056 0.0056
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0057 0.0042 0.0831
Echinococcus multilocularis membrane bound transcription factor site 1 0.0305 0.0401 0.0496
Schistosoma mansoni serine/threonine protein kinase 0.0089 0.0089 0.0085
Echinococcus multilocularis nuclear receptor 2C2 associated protein 0.0042 0.0021 0.0021
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0305 0.0401 0.0397
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.1378 0.1954 0.3202
Toxoplasma gondii F5/8 type C domain-containing protein 0.0042 0.0021 0.0426
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0055 0.0039 0.0035
Brugia malayi Integrin beta pat-3 precursor 0.425 0.6108 0.6105
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0131 0.0149 0.0181
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.01 0.0105 0.1952
Plasmodium vivax plasmepsin IV, putative 0.0035 0.001 0.0112
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0053 0.0037 0.0782
Mycobacterium tuberculosis Probable thioesterase TesA 0.0047 0.0027 0.0544
Schistosoma mansoni tyrosine kinase 0.0403 0.0543 0.0539
Toxoplasma gondii SWIRM domain-containing protein 0.0042 0.002 0.0413
Brugia malayi Disintegrin family protein 0.0037 0.0014 0.0004
Loa Loa (eye worm) hypothetical protein 0.0042 0.0021 0.0021
Echinococcus multilocularis fibrillin 2 0.0125 0.0141 0.0172
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.1683 0.2395 0.2392
Schistosoma mansoni protein kinase 0.0131 0.0149 0.0145
Giardia lamblia Tenascin-X 0.0125 0.0141 0.0332
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0047 0.0027 0.0462
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0053 0.0037 0.0702
Loa Loa (eye worm) hypothetical protein 0.1017 0.1431 0.1431
Trypanosoma brucei subtilisin peptidase 0.0305 0.0401 0.6388
Onchocerca volvulus 0.0069 0.006 0.0691
Onchocerca volvulus 0.0069 0.006 0.0691
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.045 0.0611 1
Echinococcus granulosus lysine specific histone demethylase 1A 0.0494 0.0674 0.067
Loa Loa (eye worm) hypothetical protein 0.0035 0.001 0.001
Brugia malayi ADAM-TS Spacer 1 family protein 0.0052 0.0036 0.0026
Loa Loa (eye worm) hypothetical protein 0.0115 0.0126 0.0126
Schistosoma mansoni hypothetical protein 0.0055 0.0039 0.0035
Plasmodium vivax aspartyl protease, putative 0.0035 0.001 0.0112
Brugia malayi Integrin alpha cytoplasmic region family protein 0.1017 0.1431 0.1423
Leishmania major sir2-family protein-like protein 0.0066 0.0056 0.0856
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0042 0.0021 0.0297
Onchocerca volvulus 0.0052 0.0036 0.0361
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0066 0.0056 0.0465
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0066 0.0056 0.0065
Loa Loa (eye worm) hypothetical protein 0.0035 0.001 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0305 0.0401 0.0651
Loa Loa (eye worm) WD40 repeat protein 0.0139 0.0161 0.0161
Brugia malayi serpin 0.0048 0.003 0.0021
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0066 0.0056 0.0052
Echinococcus granulosus discoidin domain containing receptor 2 0.0042 0.0021 0.0017
Brugia malayi celfurPC protein 0.5562 0.8006 0.8004
Trichomonas vaginalis hypothetical protein 0.0125 0.0141 0.0225
Onchocerca volvulus 0.0048 0.003 0.0284
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0494 0.0674 0.067
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0117 0.013 0.0126
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1683 0.2395 0.3925
Plasmodium falciparum plasmepsin II 0.0035 0.001 0.0112
Loa Loa (eye worm) reprolysin 0.009 0.009 0.009
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.045 0.0611 1
Echinococcus multilocularis adam 0.0243 0.0311 0.0384
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1683 0.2395 0.3925
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0305 0.0401 0.0651
Loa Loa (eye worm) hypothetical protein 0.0035 0.001 0.001
Echinococcus multilocularis discoidin domain containing receptor 2 0.0042 0.0021 0.0021
Onchocerca volvulus 0.0035 0.001 0.0007
Plasmodium vivax plasmepsin V, putative 0.0388 0.0521 1
Trypanosoma brucei Silent information regulator 2 related protein 1 0.045 0.0611 1
Onchocerca volvulus 0.0035 0.001 0.0007
Loa Loa (eye worm) hypothetical protein 0.0052 0.0036 0.0036
Mycobacterium ulcerans Type I modular polyketide synthase 0.0053 0.0037 0.0702
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0081 0.0077 0.1798
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.045 0.0611 1
Echinococcus granulosus integrin alpha ps 0.0359 0.048 0.0476
Toxoplasma gondii subtilisin SUB7 0.0305 0.0401 0.8492
Echinococcus multilocularis Estrogen regulated protein EP45 0.0048 0.003 0.0033
Loa Loa (eye worm) hypothetical protein 0.0048 0.003 0.003
Brugia malayi Protein kinase domain containing protein 0.0042 0.0021 0.0012
Brugia malayi serpin 0.0048 0.003 0.0021
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0235 0.03 0.0296
Toxoplasma gondii type I fatty acid synthase, putative 0.004 0.0018 0.0356
Echinococcus multilocularis serine:threonine protein kinase N2 0.0082 0.0078 0.0093
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.1378 0.1954 0.3202
Echinococcus granulosus integrin alpha ps 0.0814 0.1138 0.1135
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.009 0.009 0.0107
Schistosoma mansoni SWI/SNF complex-related 0.0042 0.002 0.0016
Schistosoma mansoni hypothetical protein 0.0359 0.048 0.0476
Loa Loa (eye worm) hypothetical protein 0.0142 0.0165 0.0165
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0066 0.0056 0.0085
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.001 0.0006
Schistosoma mansoni serpin 0.0048 0.003 0.0026
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0057 0.0042 0.0831
Schistosoma mansoni chromatin regulatory protein sir2 0.0066 0.0056 0.0052
Loa Loa (eye worm) endoprotease bli-4 0.694 1 1
Brugia malayi neuroendocrine convertase 1 precursor 0.4382 0.63 0.6297
Trichomonas vaginalis hypothetical protein 0.1378 0.1954 0.3202
Echinococcus granulosus integrin alpha 3 0.1079 0.152 0.1517
Schistosoma mansoni hypothetical protein 0.1378 0.1954 0.1951
Entamoeba histolytica hypothetical protein 0.0048 0.0029 0.0144
Brugia malayi Will die slowly protein 0.0139 0.0161 0.0152
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0066 0.0056 0.1265
Toxoplasma gondii subtilisin SUB8 0.0305 0.0401 0.8492
Trichomonas vaginalis conserved hypothetical protein 0.1378 0.1954 0.3202
Mycobacterium ulcerans dehydrogenase 0.01 0.0105 0.2446
Loa Loa (eye worm) hypothetical protein 0.01 0.0105 0.0105
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0066 0.0056 0.0098
Schistosoma mansoni site-1 peptidase (S08 family) 0.0305 0.0401 0.0397
Trichomonas vaginalis hypothetical protein 0.0042 0.0021 0.0028
Echinococcus granulosus Tolloid protein 1 0.0038 0.0015 0.0011
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0066 0.0056 0.0085
Echinococcus granulosus c-Jun N-terminal kinases 0.0762 0.1062 0.1058
Echinococcus granulosus epidermal growth factor receptor 0.0403 0.0543 0.0539
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0043 0.0022 0.0407
Echinococcus multilocularis C type lectin domian containing protein 0.0035 0.001 0.0007
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0305 0.0401 0.0651
Loa Loa (eye worm) hypothetical protein 0.0048 0.003 0.003
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0305 0.0401 0.0651
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0042 0.0021 0.0297
Giardia lamblia Neurogenic locus notch-like protein 0.0125 0.0141 0.0332
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0686 0.0952 0.1184
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0305 0.0401 0.0651
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0037 0.0014 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.002 0.0027
Brugia malayi serpin (BmSERPIN) 0.0048 0.003 0.0021
Mycobacterium ulcerans thioesterase TesA 0.0047 0.0027 0.0462
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0305 0.0401 0.0651
Echinococcus granulosus fibrillin 2 0.0125 0.0141 0.0137
Brugia malayi Angiotensin-converting enzyme family protein 0.0622 0.086 0.0852
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0021 0.0028
Schistosoma mansoni growth factor receptor-bound protein 0.0126 0.0143 0.0139
Loa Loa (eye worm) hypothetical protein 0.0042 0.0021 0.0021
Echinococcus granulosus serine protease inhibitor 0.0048 0.003 0.0026
Loa Loa (eye worm) hypothetical protein 0.0048 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0036 0.0013 0.0013
Brugia malayi hypothetical protein 0.0648 0.0897 0.0888
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0021 0.0028
Echinococcus multilocularis neuroendocrine convertase 2 0.4382 0.63 0.7868
Trichomonas vaginalis conserved hypothetical protein 0.1378 0.1954 0.3202
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0066 0.0056 0.0085
Loa Loa (eye worm) hypothetical protein 0.0042 0.002 0.002
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0066 0.0056 0.0052
Echinococcus multilocularis c4b binding protein beta chain 0.0035 0.001 0.0007
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0113 0.0124 0.0124
Mycobacterium tuberculosis Possible oxidoreductase 0.01 0.0105 0.251
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0305 0.0401 0.0651
Echinococcus granulosus Estrogen regulated protein EP45 0.0048 0.003 0.0026
Echinococcus multilocularis protein jagged 2 0.0125 0.0141 0.0172
Toxoplasma gondii histone deacetylase SIR2-like 0.0066 0.0056 0.1169
Trichomonas vaginalis conserved hypothetical protein 0.1378 0.1954 0.3202
Plasmodium falciparum subtilisin-like protease 1 0.0305 0.0401 0.7663
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.033 0.0437 0.7009
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0066 0.0056 0.0085
Loa Loa (eye worm) TK/ALK protein kinase 0.0069 0.006 0.006
Plasmodium vivax aspartyl proteinase, putative 0.0035 0.001 0.0112
Mycobacterium leprae Polyketide synthase Pks13 0.0081 0.0077 0.1727
Loa Loa (eye worm) hypothetical protein 0.0035 0.001 0.001
Onchocerca volvulus 0.0035 0.001 0.0007
Echinococcus multilocularis chromatin regulatory protein sir2 0.045 0.0611 0.0758
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0066 0.0056 0.1003
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0686 0.0952 0.0948
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0066 0.0056 0.0085
Loa Loa (eye worm) integrin alpha pat-2 0.2061 0.2942 0.2942
Brugia malayi serpin 0.0048 0.003 0.0021
Entamoeba histolytica hypothetical protein, conserved 0.0066 0.0056 0.0603
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0305 0.0401 0.0397
Giardia lamblia Tenascin-37 0.0125 0.0141 0.0332
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1683 0.2395 0.3925
Giardia lamblia Serpin 1 0.0048 0.003 0.0027
Loa Loa (eye worm) hypothetical protein 0.0069 0.006 0.006
Toxoplasma gondii aspartyl protease ASP5 0.0354 0.0472 1
Schistosoma mansoni serpin 0.0048 0.003 0.0026
Plasmodium falciparum plasmepsin VIII, putative 0.0035 0.001 0.0112
Schistosoma mansoni serine/threonine protein kinase 0.0762 0.1062 0.1058
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1683 0.2395 0.3925
Schistosoma mansoni chromatin regulatory protein sir2 0.045 0.0611 0.0607
Plasmodium vivax aspartyl protease, putative 0.0035 0.001 0.0112
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0055 0.0039 0.0035
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.045 0.0611 0.0607
Onchocerca volvulus 0.0035 0.001 0.0007
Schistosoma mansoni integrin alpha 0.1469 0.2085 0.2082
Schistosoma mansoni site-1 peptidase (S08 family) 0.0305 0.0401 0.0397
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0066 0.0056 0.0085
Echinococcus granulosus MAM 0.0069 0.006 0.0056
Loa Loa (eye worm) serpin protein 6 0.0048 0.003 0.003
Onchocerca volvulus 0.0042 0.0021 0.0159
Toxoplasma gondii subtilisin SUB4 0.0305 0.0401 0.8492
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0673 0.0933 0.0933
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.033 0.0437 0.7009
Loa Loa (eye worm) hypothetical protein 0.0125 0.0141 0.0141
Plasmodium vivax NAD-dependent deacetylase, putative 0.0066 0.0056 0.1003
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0103 0.0109 0.01
Trichomonas vaginalis conserved hypothetical protein 0.1378 0.1954 0.3202
Trichomonas vaginalis conserved hypothetical protein 0.0305 0.0401 0.0651
Trichomonas vaginalis conserved hypothetical protein 0.1378 0.1954 0.3202
Mycobacterium ulcerans polyketide synthase 0.0057 0.0042 0.0831
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1683 0.2395 0.3925
Leishmania major subtilisin-like serine peptidase 0.0305 0.0401 0.6536
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0066 0.0056 0.0065
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0305 0.0401 1
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.01 0.0105 0.2446
Giardia lamblia Tenascin precursor 0.0125 0.0141 0.0332
Loa Loa (eye worm) hypothetical protein 0.0494 0.0674 0.0674
Loa Loa (eye worm) hypothetical protein 0.0048 0.003 0.003
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1291 0.1828 0.1825
Loa Loa (eye worm) hypothetical protein 0.01 0.0105 0.0105
Schistosoma mansoni dihydroceramide desaturase 0.0037 0.0014 0.001
Schistosoma mansoni discoidin domain receptor 0.0042 0.0021 0.0017
Loa Loa (eye worm) hypothetical protein 0.0044 0.0023 0.0023
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.01 0.0105 0.2213
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0305 0.0401 0.0651
Plasmodium vivax hypothetical protein, conserved 0.01 0.0105 0.1952
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.002 0.0027
Brugia malayi EGF-like domain containing protein 0.0125 0.0141 0.0132
Echinococcus multilocularis integrin alpha 3 0.1079 0.152 0.1895
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0305 0.0401 0.0651
Onchocerca volvulus 0.0048 0.003 0.0284
Plasmodium vivax hypothetical protein, conserved 0.01 0.0105 0.1952
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0125 0.0141 0.0225
Loa Loa (eye worm) hypothetical protein 0.0069 0.006 0.006
Loa Loa (eye worm) aspartyl protease 6 0.0035 0.001 0.001
Brugia malayi Protein kinase domain containing protein 0.0069 0.006 0.005
Brugia malayi BmSERPIN 0.0048 0.003 0.0021
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.001 0.0006
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0057 0.0042 0.0909
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0035 0.001 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0021 0.0028
Echinococcus multilocularis protein kinase c epsilon type 0.0089 0.0089 0.0106
Echinococcus granulosus plasminogen activator inhibitor 2 0.0048 0.003 0.0026
Brugia malayi Furin-like cysteine rich region family protein 0.0403 0.0543 0.0534
Toxoplasma gondii subtilisin SUB6 0.0305 0.0401 0.8492
Echinococcus multilocularis discoidin domain containing receptor 2 0.0042 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0048 0.003 0.003
Plasmodium vivax LCCL domain-containing protein 0.0042 0.0021 0.0327
Schistosoma mansoni cathepsin D (A01 family) 0.0035 0.001 0.0006
Entamoeba histolytica PH domain containing protein kinase, putative 0.0073 0.0066 0.0767
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0053 0.0037 0.0702
Plasmodium falciparum plasmepsin VII 0.0035 0.001 0.0112
Loa Loa (eye worm) subtilase 0.0305 0.0401 0.0401
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0494 0.0674 0.0837
Echinococcus multilocularis integrin beta 2 0.3145 0.451 0.5631
Brugia malayi GCC2 and GCC3 family protein 0.0044 0.0023 0.0014
Plasmodium falciparum LCCL domain-containing protein 0.0042 0.0021 0.0327
Schistosoma mansoni hypothetical protein 0.0139 0.0161 0.0157
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.0042 0.002 0.002
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.045 0.0611 0.0996
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.01 0.0105 0.2446
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.001 0.0006
Echinococcus granulosus discoidin domain containing receptor 2 0.0042 0.0021 0.0017
Echinococcus multilocularis discoidin domain containing receptor 2 0.0042 0.0021 0.0021
Echinococcus granulosus growth factor receptor bound protein 2 0.0126 0.0143 0.0139
Brugia malayi amine oxidase, flavin-containing family protein 0.0142 0.0165 0.0156
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.01 0.0105 0.1952
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0305 0.0401 0.0391
Mycobacterium ulcerans oxidoreductase 0.01 0.0105 0.2446
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0762 0.1062 0.1062
Toxoplasma gondii histone deacetylase SIR2 0.0066 0.0056 0.1169
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0305 0.0401 0.0651

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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