Detailed information for compound 82979

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 276.336 | Formula: C17H16N4
  • H donors: 2 H acceptors: 2 LogP: 3.05 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1ncc(c(n1)N)Cc1ccc(cc1)c1ccccc1
  • InChi: 1S/C17H16N4/c18-16-15(11-20-17(19)21-16)10-12-6-8-14(9-7-12)13-4-2-1-3-5-13/h1-9,11H,10H2,(H4,18,19,20,21)
  • InChiKey: UVFCOEHLSTZCHI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli Dihydrofolate reductase Starlite/ChEMBL References
Gallus gallus Dihydrofolate reductase Starlite/ChEMBL References
Salmonella enterica subsp. enterica serovar Typhi Dihydrofolate reductase Starlite/ChEMBL References
Lactobacillus casei Dihydrofolate reductase Starlite/ChEMBL References
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase Curated by TDR Targets References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Candida albicans dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Brugia malayi Dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Candida albicans Thymidylate synthase capable of functional substitution for S. cerevisiae CDC21 (YOR074C) Get druggable targets OG5_127385 All targets in OG5_127385
Brugia malayi dihydrofolate reductase family protein Get druggable targets OG5_128410 All targets in OG5_128410
Chlamydia trachomatis dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Leishmania major dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127385 All targets in OG5_127385
Schistosoma mansoni dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Trypanosoma brucei gambiense dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) Get druggable targets OG5_128410 All targets in OG5_128410
Echinococcus granulosus thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Schistosoma japonicum ko:K00287 dihydrofolate reductase [EC1.5.1.3], putative Get druggable targets OG5_128410 All targets in OG5_128410
Plasmodium knowlesi bifunctional dihydrofolate reductase-thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) Get druggable targets OG5_127385 All targets in OG5_127385
Loa Loa (eye worm) thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Neospora caninum Bifunctional dihydrofolate reductase-thymidylate synthase, related Get druggable targets OG5_127385 All targets in OG5_127385
Echinococcus multilocularis dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Leishmania mexicana dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Candida albicans Thymidylate synthase capable of functional substitution for S. cerevisiae CDC21 (YOR074C) Get druggable targets OG5_127385 All targets in OG5_127385
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) Get druggable targets OG5_127385 All targets in OG5_127385
Brugia malayi thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium berghei bifunctional dihydrofolate reductase-thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Cryptosporidium parvum dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Babesia bovis dihydrofolate reductase/thymidilate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Candida albicans hypothetical protein Get druggable targets OG5_128410 All targets in OG5_128410
Onchocerca volvulus Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Mycobacterium ulcerans thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Echinococcus granulosus dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Plasmodium yoelii thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Candida albicans dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Schistosoma japonicum ko:K00560 thymidylate synthase [EC2.1.1.45], putative Get druggable targets OG5_127385 All targets in OG5_127385
Mycobacterium ulcerans dihydrofolate reductase DfrA Get druggable targets OG5_128410 All targets in OG5_128410
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania braziliensis dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Theileria parva dihydrofolate reductase-thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania donovani dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Cryptosporidium hominis chain A, crystal structure of Dhfr Get druggable targets OG5_127385 All targets in OG5_127385
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) Get druggable targets OG5_128410 All targets in OG5_128410
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania infantum dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Echinococcus multilocularis thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Loa Loa (eye worm) dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Theileria parva dihydrofolate reductase-thymidylate synthase, putative Dihydrofolate reductase   189 aa 194 aa 31.4 %
Babesia bovis dihydrofolate reductase/thymidilate synthase Dihydrofolate reductase   189 aa 189 aa 31.7 %
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative Dihydrofolate reductase   189 aa 209 aa 28.2 %
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   189 aa 201 aa 29.4 %
Cryptosporidium parvum mannose-1-phosphate guanylyltransferase Dihydrofolate reductase   157 aa 139 aa 27.3 %
Candida albicans dihydrofolate reductase Dihydrofolate reductase   157 aa 149 aa 29.5 %
Cryptosporidium hominis GDP-mannose pyrophosphorylase (4N40) Dihydrofolate reductase   157 aa 139 aa 28.1 %
Leishmania major serine carboxypeptidase (CBP1), putative,serine peptidase, Clan SC, Family S10 Dihydrofolate reductase   157 aa 159 aa 21.4 %
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   189 aa 154 aa 33.8 %
Onchocerca volvulus Putative dihydrofolate reductase Dihydrofolate reductase   163 aa 173 aa 27.2 %
Leishmania infantum dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   189 aa 172 aa 34.3 %
Plasmodium vivax hypothetical protein, conserved Dihydrofolate reductase   157 aa 127 aa 26.8 %
Cryptosporidium parvum dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   159 aa 173 aa 30.6 %
Dictyostelium discoideum dihydrofolate reductase Dihydrofolate reductase   157 aa 146 aa 27.4 %
Candida albicans dihydrofolate reductase Dihydrofolate reductase   157 aa 149 aa 29.5 %
Echinococcus multilocularis EF hand calcium binding domain containing protein Dihydrofolate reductase   189 aa 155 aa 22.6 %
Plasmodium yoelii thymidylate synthase, putative Dihydrofolate reductase   163 aa 139 aa 21.6 %
Leishmania major dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   189 aa 172 aa 34.3 %
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   189 aa 185 aa 35.7 %
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   159 aa 130 aa 30.8 %
Plasmodium knowlesi bifunctional dihydrofolate reductase-thymidylate synthase, putative Dihydrofolate reductase   189 aa 209 aa 28.7 %
Schistosoma mansoni dihydrofolate reductase Dihydrofolate reductase   157 aa 147 aa 28.6 %
Neospora caninum Bifunctional dihydrofolate reductase-thymidylate synthase, related Dihydrofolate reductase   189 aa 180 aa 34.4 %
Chlamydia trachomatis dihydrofolate reductase Dihydrofolate reductase   157 aa 133 aa 24.8 %
Leishmania infantum serine carboxypeptidase (CBP1), putative,serine peptidase, Clan SC, Family S10 Dihydrofolate reductase   157 aa 159 aa 23.3 %
Trypanosoma cruzi ATP- dependent RNA helicase, putative Dihydrofolate reductase   157 aa 140 aa 22.9 %
Plasmodium falciparum dihydrofolate synthase/folylpolyglutamate synthase Dihydrofolate reductase   157 aa 127 aa 19.7 %
Leishmania mexicana dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   189 aa 172 aa 33.1 %
Plasmodium yoelii hypothetical protein Dihydrofolate reductase   157 aa 132 aa 24.2 %
Leishmania donovani dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   189 aa 172 aa 34.3 %
Onchocerca volvulus Germline survival defective-1 homolog Dihydrofolate reductase   159 aa 166 aa 26.5 %
Leishmania donovani serine carboxypeptidase (CBP1), putative Dihydrofolate reductase   157 aa 159 aa 23.3 %
Plasmodium berghei bifunctional dihydrofolate reductase-thymidylate synthase, putative Dihydrofolate reductase   189 aa 212 aa 29.2 %
Leishmania braziliensis dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   189 aa 172 aa 33.7 %
Candida albicans hypothetical protein Dihydrofolate reductase   157 aa 149 aa 29.5 %
Cryptosporidium hominis chain A, crystal structure of Dhfr Dihydrofolate reductase   159 aa 173 aa 31.8 %
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) Dihydrofolate reductase   157 aa 158 aa 29.1 %
Trypanosoma brucei gambiense dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   159 aa 130 aa 30.8 %
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) Dihydrofolate reductase   157 aa 160 aa 29.4 %
Mycobacterium ulcerans dihydrofolate reductase DfrA Dihydrofolate reductase   157 aa 159 aa 28.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0011 0.0004
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.0296 0.1072
Schistosoma mansoni dihydrofolate reductase 0.0755 0.2372 0.5151
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0034 0.0108
Entamoeba histolytica hypothetical protein 0.0146 0.0417 0.1199
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0378 0.0812
Trypanosoma brucei calpain-like protein, putative 0.002 0.0013 0.0018
Trypanosoma brucei telomerase reverse transcriptase 0.0855 0.2694 1
Plasmodium vivax importin-beta 2, putative 0.0028 0.0039 0.0146
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0055 0.016
Plasmodium vivax hypothetical protein, conserved 0.0046 0.0097 0.036
Schistosoma mansoni RAR-like nuclear receptor 0.0041 0.008 0.0165
Trypanosoma brucei exonuclease, putative 0.0022 0.0018 0.0038
Loa Loa (eye worm) flap endonuclease-1 0.0107 0.0293 0.1217
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0054 0.0123 0.042
Brugia malayi Latrophilin receptor protein 2 0.005 0.0109 0.0137
Echinococcus granulosus expressed protein 0.0372 0.1142 0.2468
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0115 0.0385
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0092 0.0362
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0041 0.008 0.0098
Toxoplasma gondii hypothetical protein 0.0097 0.0261 0.0932
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.0133 0.0539
Loa Loa (eye worm) mbt repeat family protein 0.01 0.027 0.1122
Echinococcus granulosus jun protein 0.0184 0.0539 0.1155
Trypanosoma brucei DNA polymerase kappa, putative 0.0163 0.0473 0.173
Onchocerca volvulus Alhambra homolog 0.0031 0.0046 0.0045
Schistosoma mansoni ap endonuclease 0.0057 0.0133 0.0279
Echinococcus granulosus FTZ F1 alpha 0.0041 0.008 0.0156
Brugia malayi orphan nuclear receptor NR2E1 0.0019 0.0011 0.0002
Schistosoma mansoni alzheimer's disease beta-amyloid related 0.0111 0.0305 0.0654
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0173 0.0504 0.2029
Brugia malayi hypothetical protein 0.002 0.0012 0.0004
Leishmania major hypothetical protein, conserved 0.002 0.0012 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0041 0.008 0.0098
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.0406 0.0865
Brugia malayi Associated with TFs and helicases family protein 0.007 0.0173 0.0226
Echinococcus granulosus histone acetyltransferase MYST2 0.0114 0.0315 0.0666
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.013 0.0365 0.1435
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0029 0.0086
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.009 0.0236 0.0503
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0134 0.0378 0.1577
Echinococcus multilocularis BRK domain containing protein 0.0024 0.0024 0.0034
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0041 0.008 0.0156
Loa Loa (eye worm) glutaminase 2 0.0546 0.1701 0.7166
Brugia malayi M-phase phosphoprotein, mpp8 0.0136 0.0384 0.0518
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0069 0.017 0.0352
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0042 0.0083 0.027
Schistosoma mansoni hypothetical protein 0.0032 0.005 0.0099
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0046 0.0097 0.0257
Brugia malayi Smad1 0.0025 0.0029 0.0028
Echinococcus granulosus calpain 5 0.002 0.0013 0.0009
Trypanosoma cruzi polo-like protein kinase, putative 0.0197 0.0579 0.2115
Echinococcus granulosus disco interacting protein 2 0.0039 0.0073 0.014
Entamoeba histolytica DNA-repair protein, putative 0.0022 0.0018 0.0025
Giardia lamblia Kinase, CMGC MAPK 0.0054 0.0123 0.0309
Brugia malayi steroid hormone receptor 0.0041 0.008 0.0098
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0073 0.0231
Loa Loa (eye worm) hypothetical protein 0.0158 0.0455 0.1903
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0085 0.0221 0.0792
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.0018 0.002
Loa Loa (eye worm) RecQ helicase 0.0138 0.0391 0.1631
Echinococcus granulosus ecdysone induced protein 78C 0.0041 0.008 0.0156
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0045 0.0092 0.0191
Brugia malayi hypothetical protein 0.002 0.0012 0.0004
Echinococcus granulosus exonuclease 1 0.0022 0.0018 0.0021
Schistosoma mansoni nuclear hormone receptor 0.0041 0.008 0.0165
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.005 0.0109 0.0218
Brugia malayi Inositol-1 0.0039 0.0073 0.0087
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0011 0.0002
Brugia malayi Muscleblind-like protein 0.0612 0.1913 0.2628
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0046 0.0097 0.0322
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0011 0.0004
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.0296 0.0634
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0046 0.0097 0.0257
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.002 0.0013 0.0018
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.0079 0.0201 0.0711
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0021 0.0015 0.0044
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0123 0.0498
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0296 0.1256
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0042 0.0143
Echinococcus multilocularis 6 phosphofructokinase 0.0108 0.0296 0.0626
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0083 0.0216 0.076
Schistosoma mansoni phosphoglycerate kinase 0.0173 0.0504 0.1087
Echinococcus multilocularis histone lysine N methyltransferase, H3 lysine 36 0.0027 0.0036 0.006
Echinococcus granulosus axis inhibition protein axin 0.0019 0.001 0.0002
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0073 0.0276
Brugia malayi Bromodomain containing protein 0.0163 0.0473 0.064
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0008 0.0031
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0017
Loa Loa (eye worm) jmjC domain-containing protein 0.0046 0.0096 0.0386
Loa Loa (eye worm) hypothetical protein 0.0047 0.01 0.0406
Brugia malayi nuclear receptor NHR-67 0.0019 0.0011 0.0002
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0013 0.0008
Schistosoma mansoni myelin transcription factor 1 myt1 0.0114 0.0315 0.0675
Schistosoma mansoni coup transcription factor 0.0041 0.008 0.0165
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0083 0.0264
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0018 0.0012
Leishmania major DNA polymerase kappa, putative 0.0042 0.0083 0.027
Brugia malayi nuclear receptor RXR 0.0022 0.0018 0.0012
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0085 0.0166
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0012 0.0011
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0054 0.0123 0.0415
Loa Loa (eye worm) hypothetical protein 0.0022 0.0018 0.0058
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0052 0.0114 0.0229
Entamoeba histolytica deoxycytidyl transferase, putative 0.0135 0.0382 0.1095
Brugia malayi phosphofructokinase 0.0108 0.0296 0.0396
Trichomonas vaginalis chromobox protein, putative 0.014 0.0398 0.1702
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0026
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0041 0.008 0.0079
Trypanosoma brucei unspecified product 0.0093 0.0247 0.0891
Loa Loa (eye worm) hypothetical protein 0.0052 0.0115 0.0468
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0033 0.0104
Echinococcus granulosus histone lysine methyltransferase setb 0.0131 0.0368 0.0783
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0107 0.0293 0.1051
Echinococcus granulosus calpain 0.002 0.0013 0.0009
Echinococcus multilocularis GPCR, family 2 0.005 0.0109 0.0218
Brugia malayi jmjC domain containing protein 0.01 0.0269 0.0359
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.005 0.0109 0.0137
Echinococcus multilocularis calpain 5 0.002 0.0013 0.0009
Brugia malayi hypothetical protein 0.0121 0.0338 0.0453
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0021 0.0015 0.0044
Trypanosoma brucei phosphoglycerate kinase 0.0064 0.0152 0.0537
Entamoeba histolytica DNA (cytosine-5)-methyltransferase, putative 0.0019 0.0011 0.0003
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0071 0.0176 0.0364
Entamoeba histolytica protein kinase, putative 0.0022 0.0018 0.0024
Trichomonas vaginalis helicase, putative 0.002 0.0012 0.0011
Entamoeba histolytica hypothetical protein 0.0046 0.0097 0.0257
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0026 0.0071
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0064 0.0155 0.0637
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0378 0.0812
Echinococcus multilocularis DNA methyltransferase 2, putative 0.0019 0.0011 0.0004
Loa Loa (eye worm) hypothetical protein 0.0041 0.008 0.032
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0107 0.0293 0.1051
Trypanosoma cruzi polo-like protein kinase, putative 0.0197 0.0579 0.2115
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.0011 0.0009
Trypanosoma cruzi DNA damage repair protein, putative 0.0042 0.0083 0.0264
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0071 0.0176 0.0373
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0042 0.0143
Echinococcus granulosus thymidylate synthase 0.013 0.0365 0.0776
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0132 0.0372 0.079
Plasmodium vivax hypothetical protein, conserved 0.0046 0.0097 0.036
Loa Loa (eye worm) CHromoDomain protein family member 0.0055 0.0126 0.0512
Schistosoma mansoni hypothetical protein 0.002 0.0012 0.0017
Onchocerca volvulus 0.0041 0.008 0.0079
Brugia malayi Flap endonuclease-1 0.0107 0.0293 0.0391
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0013 0.0003
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0115 0.0385
Loa Loa (eye worm) hypothetical protein 0.0022 0.0018 0.0058
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0285 0.0865 0.3184
Loa Loa (eye worm) dihydrofolate reductase 0.0755 0.2372 1
Schistosoma mansoni glutaminase 0.0546 0.1701 0.3692
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0012 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0097 0.0383
Schistosoma mansoni SET domain protein 0.0036 0.0065 0.0132
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0029 0.0105
Schistosoma mansoni exonuclease 0.0022 0.0018 0.003
Loa Loa (eye worm) XPG I-region family protein 0.0022 0.0018 0.0059
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.0079 0.0201 0.0832
Brugia malayi hypothetical protein 0.0019 0.001 0.0001
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0066 0.0161 0.0662
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0092 0.0362
Schistosoma mansoni DNA polymerase IV / kappa 0.0042 0.0083 0.0171
Brugia malayi hypothetical protein 0.0136 0.0384 0.0518
Echinococcus multilocularis PWWP domain containing protein 2A 0.002 0.0012 0.0007
Echinococcus multilocularis mitogen activated protein kinase 3 0.0054 0.0123 0.0249
Loa Loa (eye worm) phosphofructokinase 0.0108 0.0296 0.1231
Echinococcus multilocularis regulator of G protein signaling 7 0.0028 0.004 0.0068
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0041 0.008 0.032
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0022 0.0018 0.0029
Loa Loa (eye worm) hypothetical protein 0.0022 0.0018 0.0058
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0378 0.0812
Echinococcus granulosus beta-adrenergic receptor kinase 0.0021 0.0015 0.0013
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0034 0.0057 0.0224
Trichomonas vaginalis conserved hypothetical protein 0.0131 0.0368 0.1574
Echinococcus granulosus regulator of G protein signaling 7 0.0028 0.004 0.0068
Brugia malayi Dihydrofolate reductase 0.0755 0.2372 0.3261
Trypanosoma brucei DNA polymerase kappa, putative 0.0163 0.0473 0.173
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0008 0.0014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0041 0.008 0.032
Schistosoma mansoni smad1 5 8 and 0.0025 0.0029 0.0054
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0132 0.0372 0.079
Trypanosoma brucei polo-like protein kinase 0.0197 0.0579 0.2127
Trichomonas vaginalis STE family protein kinase 0.0079 0.0201 0.0841
Schistosoma mansoni hypothetical protein 0.0146 0.0417 0.0898
Entamoeba histolytica calpain large subunit domain III containing protein 0.002 0.0013 0.0009
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0197 0.0579 0.212
Echinococcus multilocularis lamin 0.0028 0.004 0.0067
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0013 0.0003
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.0055 0.0165
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.008 0.0098
Onchocerca volvulus Heterochromatin protein 1 homolog 0.014 0.0398 0.0396
Loa Loa (eye worm) hypothetical protein 0.0094 0.0249 0.1034
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.05 0.1554 0.5755
Trypanosoma brucei DNA polymerase kappa, putative 0.01 0.027 0.0975
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0071 0.0175 0.0363
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.0083 0.0279
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0027 0.0036 0.006
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.001 0.0001
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0046 0.0172
Schistosoma mansoni sex comb on midleg homolog 0.01 0.027 0.0578
Giardia lamblia DINP protein human, muc B family 0.0142 0.0404 0.1139
Onchocerca volvulus 0.0136 0.0384 0.0383
Echinococcus multilocularis BRK domain containing protein 0.0024 0.0024 0.0034
Brugia malayi F/Y-rich N-terminus family protein 0.0046 0.0097 0.0121
Mycobacterium ulcerans hypothetical protein 0.0025 0.0029 0.0086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0071 0.0269
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0108 0.0296 0.1229
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0046 0.0097 0.0121
Plasmodium vivax heterochromatin protein 1, putative 0.0046 0.0097 0.036
Brugia malayi Pre-SET motif family protein 0.0096 0.0255 0.0339
Echinococcus granulosus dnaJ subfamily B 0.1248 0.3954 0.8592
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0041 0.008 0.0165
Trypanosoma brucei phosphoglycerate kinase 0.0173 0.0504 0.1847
Brugia malayi 6-phosphofructokinase 0.0108 0.0296 0.0396
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0073 0.0276
Trypanosoma cruzi DNA polymerase eta, putative 0.0188 0.0552 0.2014
Echinococcus multilocularis dnaJ subfamily B 0.1248 0.3954 0.8592
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.0406 0.0865
Entamoeba histolytica hypothetical protein 0.0046 0.0097 0.0257
Loa Loa (eye worm) thymidylate synthase 0.013 0.0365 0.1523
Entamoeba histolytica recQ family DNA helicase 0.0035 0.0062 0.0153
Trichomonas vaginalis CAMK family protein kinase 0.0197 0.0579 0.25
Brugia malayi Valyl-tRNA synthetase 0.0046 0.0097 0.0121
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.001 0.0002
Brugia malayi hypothetical protein 0.0019 0.0011 0.0002
Echinococcus multilocularis SAM and MBT domain containing protein 0.01 0.027 0.0569
Onchocerca volvulus 0.0467 0.1446 0.1445
Echinococcus multilocularis jun protein 0.0184 0.0539 0.1155
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0019 0.0011 0.0002
Brugia malayi jmjC domain containing protein 0.0046 0.0096 0.0119
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.0296 0.0634
Mycobacterium ulcerans phosphoglycerate kinase 0.0173 0.0504 0.2097
Trypanosoma cruzi DNA polymerase kappa, putative 0.0163 0.0473 0.1718
Brugia malayi nuclear receptor NHR-88 0.0041 0.008 0.0098
Trypanosoma brucei DNA polymerase IV, putative 0.0163 0.0473 0.173
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0131 0.0533
Loa Loa (eye worm) hypothetical protein 0.0041 0.008 0.032
Schistosoma mansoni hypothetical protein 0.005 0.0109 0.0227
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0039 0.0107
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0041 0.008 0.0165
Echinococcus multilocularis cpg binding protein 0.0129 0.0364 0.0773
Brugia malayi PXA domain containing protein 0.0019 0.001 0.0001
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0108 0.0296 0.1141
Schistosoma mansoni phd finger protein 0.0028 0.0039 0.0076
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0042 0.0144
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0011 0.0004
Brugia malayi calpain 5 0.002 0.0013 0.0005
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0143 0.0406 0.0548
Echinococcus multilocularis chromobox protein 2 0.0046 0.0097 0.0192
Brugia malayi hypothetical protein 0.0052 0.0115 0.0146
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.001 0.0002
Brugia malayi TAR-binding protein 0.0134 0.0378 0.0509
Loa Loa (eye worm) nuclear hormone receptor 0.0019 0.0011 0.0026
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.01 0.027 0.0578
Loa Loa (eye worm) hypothetical protein 0.0022 0.0018 0.0058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0026 0.0072
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0029 0.0086
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0045 0.0092 0.0304
Echinococcus multilocularis zinc finger protein 0.0049 0.0106 0.0211
Schistosoma mansoni intermediate filament proteins 0.0028 0.004 0.0077
Schistosoma mansoni lozenge 0.0059 0.0136 0.0287
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0074 0.0186 0.0387
Trichomonas vaginalis exonuclease%2C+putative 0.0022 0.0018 0.0038
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0069 0.017 0.0352
Trichomonas vaginalis CAMK family protein kinase 0.0197 0.0579 0.25
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0063 0.0233
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0029 0.0054
Entamoeba histolytica hypothetical protein 0.0146 0.0417 0.1199
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0123 0.0415
Brugia malayi PHD-finger family protein 0.006 0.0141 0.0182
Echinococcus granulosus thyroid hormone receptor alpha 0.0019 0.0011 0.0004
Plasmodium vivax DNA repair protein RAD2, putative 0.0022 0.0018 0.0068
Trypanosoma cruzi DNA polymerase kappa, putative 0.0163 0.0473 0.1718
Echinococcus multilocularis muscleblind protein 1 0.0612 0.1913 0.4148
Echinococcus multilocularis disco interacting protein 2 0.0039 0.0073 0.014
Echinococcus granulosus chromobox protein 1 0.0225 0.0669 0.1438
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0046 0.0097 0.0201
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0041 0.008 0.0098
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0115 0.0398
Giardia lamblia GTOR 0.0045 0.0092 0.0218
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0755 0.2372 1
Schistosoma mansoni blooms syndrome DNA helicase 0.0035 0.0062 0.0124
Loa Loa (eye worm) hypothetical protein 0.0025 0.0029 0.0102
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0191 0.0563 0.1216
Loa Loa (eye worm) hypothetical protein 0.0046 0.0097 0.0391
Entamoeba histolytica recQ family helicase, putative 0.0034 0.0057 0.014
Loa Loa (eye worm) hypothetical protein 0.0028 0.004 0.0149
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0296 0.1256
Loa Loa (eye worm) hypothetical protein 0.0022 0.0018 0.0058
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0066 0.0161 0.0662
Echinococcus granulosus PWWP domain containing protein 2A 0.002 0.0012 0.0007
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0035 0.0062 0.019
Schistosoma mansoni tsg101-related 0.0048 0.0103 0.0214
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0023 0.0032
Brugia malayi thymidylate synthase 0.013 0.0365 0.0491
Schistosoma mansoni microtubule-associated protein tau 0.1449 0.4601 1
Schistosoma mansoni tsg101-related 0.0059 0.0138 0.029
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0054 0.0123 0.0415
Echinococcus granulosus global transcription activator snf2l2 0.0141 0.0403 0.0858
Brugia malayi RNA, U transporter 1 0.008 0.0207 0.0272
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0045 0.0092 0.0313
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0019 0.0011 0.0004
Schistosoma mansoni hypothetical protein 0.0166 0.0482 0.1039
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0066 0.0161 0.0662
Loa Loa (eye worm) helicase 0.0046 0.0097 0.0391
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0173 0.0504 0.2108
Loa Loa (eye worm) hypothetical protein 0.0031 0.0046 0.0177
Schistosoma mansoni hypothetical protein 0.002 0.0012 0.0017
Loa Loa (eye worm) histone methyltransferase 0.0033 0.0054 0.0208
Loa Loa (eye worm) hypothetical protein 0.0022 0.0018 0.0059
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0296 0.1256
Brugia malayi mbt repeat family protein 0.01 0.027 0.036
Loa Loa (eye worm) hypothetical protein 0.0079 0.0203 0.0837
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0026
Echinococcus granulosus flap endonuclease 1 0.0107 0.0293 0.0618
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0135 0.0382 0.0821
Leishmania major phosphoglycerate kinase B, cytosolic 0.0173 0.0504 0.1839
Brugia malayi calpain 7 0.002 0.0013 0.0005
Onchocerca volvulus 0.002 0.0012 0.0011
Chlamydia trachomatis dihydrofolate reductase 0.0755 0.2372 1
Echinococcus multilocularis BRK domain containing protein 0.0024 0.0024 0.0034
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.05 0.1554 0.5756
Loa Loa (eye worm) hypothetical protein 0.0052 0.0116 0.0473
Trypanosoma cruzi DNA repair protein RAD2, putative 0.0022 0.0018 0.0024
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.001 0.0002
Echinococcus multilocularis BRK domain containing protein 0.0024 0.0024 0.0034
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.001 0.0001
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0018 0.0012
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0015 0.0023
Leishmania major phosphoglycerate kinase C, glycosomal 0.0173 0.0504 0.1839
Loa Loa (eye worm) hypothetical protein 0.0028 0.0039 0.0147
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0041 0.008 0.032
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0097 0.0383
Trypanosoma cruzi DNA polymerase kappa, putative 0.0163 0.0473 0.1718
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0067 0.0165 0.0349
Schistosoma mansoni calpain (C02 family) 0.002 0.0013 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0026 0.0072
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0131 0.0368 0.0791
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.001 0.0002
Plasmodium falciparum flap endonuclease 1 0.0107 0.0293 0.1058
Echinococcus granulosus histone lysine N methyltransferase H3 lysine 36 0.0027 0.0036 0.006
Brugia malayi nuclear hormone receptor family member odr-7 0.0019 0.0011 0.0002
Echinococcus granulosus smad 0.0025 0.0029 0.0045
Entamoeba histolytica serine/threonine protein kinase, putative 0.0197 0.0579 0.1677
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0041 0.008 0.0156
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0063 0.0233
Brugia malayi SET domain containing protein 0.0054 0.0121 0.0155
Schistosoma mansoni jumonji domain containing protein 0.0079 0.0203 0.0433
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0066 0.0161 0.0662
Trichomonas vaginalis DNA helicase recq, putative 0.0083 0.0216 0.0905
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.008 0.0156
Trypanosoma brucei protein kinase, putative 0.0054 0.0123 0.0429
Schistosoma mansoni cpg binding protein 0.0129 0.0364 0.0782
Echinococcus granulosus expressed protein 0.0034 0.0057 0.0106
Schistosoma mansoni DNA helicase recq1 0.0069 0.017 0.0361
Loa Loa (eye worm) RNA binding protein 0.0134 0.0378 0.1577
Leishmania major hypothetical protein, conserved 0.0022 0.0018 0.0029
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0039 0.0073 0.0149
Echinococcus granulosus cpg binding protein 0.0129 0.0364 0.0773
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0045 0.0092 0.0313
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0097 0.0383
Schistosoma mansoni regulator of G protein signaling 0.0019 0.001 0.0012
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0042 0.0143
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0042 0.0096
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0022 0.0018 0.0029
Schistosoma mansoni jumonji/arid domain-containing protein 0.0046 0.0096 0.0199
Trichomonas vaginalis rotamase, putative 0.0033 0.0055 0.0198
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.01 0.027 0.0269
Echinococcus multilocularis DNA repair protein complementing XP G cells 0.0022 0.0018 0.0021
Echinococcus multilocularis calpain 0.002 0.0013 0.0009
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0057 0.0133 0.1393
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0114 0.0315 0.0666
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0041 0.008 0.0156
Schistosoma mansoni DNA (cytosine-5)-methyltransferase 0.0019 0.0011 0.0013
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0011 0.0013
Schistosoma mansoni axis inhibition protein axin 0.0019 0.001 0.0012
Echinococcus multilocularis flap endonuclease 1 0.0107 0.0293 0.0618
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.008 0.0156
Echinococcus multilocularis microtubule associated protein 2 0.1449 0.4601 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0046 0.0097 0.0383
Echinococcus granulosus lysine specific demethylase 5A 0.0046 0.0096 0.0189
Plasmodium vivax exonuclease I, putative 0.0022 0.0018 0.0068
Schistosoma mansoni regulator of G protein signaling 0.0019 0.001 0.0012
Loa Loa (eye worm) steroid hormone receptor 0.0041 0.008 0.032
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0022 0.0054
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0064 0.0152 0.0523
Mycobacterium ulcerans 6-phosphofructokinase 0.0108 0.0296 0.1217
Loa Loa (eye worm) hypothetical protein 0.01 0.027 0.1122
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0022 0.0054
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.001 0.0012
Schistosoma mansoni sex comb on midleg homolog 0.01 0.027 0.0578
Onchocerca volvulus 0.0025 0.0029 0.0027
Trypanosoma brucei DNA damage repair protein, putative 0.0042 0.0083 0.0279
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0163 0.0473 0.2032
Brugia malayi hypothetical protein 0.0144 0.0412 0.0556
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0013 0.0003
Trichomonas vaginalis CAMK family protein kinase 0.0197 0.0579 0.25
Echinococcus granulosus neuropeptide receptor A26 0.0488 0.1516 0.3283
Trypanosoma cruzi ISWI complex protein 0.0032 0.005 0.0141
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.004 0.0042
Mycobacterium ulcerans thymidylate synthase 0.013 0.0365 0.1509
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0026
Echinococcus multilocularis PWWP domain containing protein 2A 0.002 0.0012 0.0007
Schistosoma mansoni protein kinase 0.0079 0.0201 0.0429
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0029 0.0086
Schistosoma mansoni hypothetical protein 0.002 0.0012 0.0017
Trypanosoma brucei DNA damage repair protein, putative 0.0042 0.0083 0.0279
Loa Loa (eye worm) hypothetical protein 0.0097 0.0259 0.1073
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0018 0.0024
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0641 0.2006 0.8454
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0042 0.0143
Trichomonas vaginalis chromobox protein, putative 0.0046 0.0097 0.0383
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0046 0.0082
Echinococcus multilocularis regulator of G protein signaling 7 0.0028 0.004 0.0068
Trypanosoma brucei unspecified product 0.0156 0.045 0.1646
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0197 0.0579 0.2428
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0039 0.0116
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0042 0.0127
Plasmodium vivax DNA repair protein REV1, putative 0.0042 0.0083 0.0308
Leishmania major DNA polymerase eta, putative 0.0095 0.0253 0.0904
Loa Loa (eye worm) hypothetical protein 0.019 0.0559 0.2342
Schistosoma mansoni nuclear receptor nhr-48 0.0019 0.0011 0.0013
Schistosoma mansoni zinc finger protein 0.0032 0.005 0.0099
Trypanosoma brucei DNA polymerase IV, putative 0.0156 0.045 0.1646
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0013 0.0003
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0061 0.0124
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0029 0.0086
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0306 0.093 0.404
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0045 0.0092 0.0304
Trichomonas vaginalis chromobox protein, putative 0.0046 0.0097 0.0383
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0114 0.0315 0.0666
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0057 0.021
Echinococcus multilocularis histone acetyltransferase MYST2 0.0114 0.0315 0.0666
Loa Loa (eye worm) hypothetical protein 0.0467 0.1446 0.609
Trypanosoma brucei DNA polymerase kappa, putative 0.0163 0.0473 0.173
Chlamydia trachomatis phosphoglycerate kinase 0.0173 0.0504 0.2097
Echinococcus granulosus dual specificity mitogen activated protein 0.0079 0.0201 0.042
Brugia malayi SET domain containing protein 0.0021 0.0015 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0017
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0041 0.008 0.032
Onchocerca volvulus 0.012 0.0335 0.0334
Schistosoma mansoni jumonji/arid domain-containing protein 0.0046 0.0096 0.0199
Schistosoma mansoni importin beta-1 0.0028 0.0039 0.0076
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0073 0.0226
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0042 0.0143
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0306 0.093 0.404
Schistosoma mansoni axis inhibition protein axin 0.0019 0.001 0.0012
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0045 0.0092 0.0182
Schistosoma mansoni hypothetical protein 0.0149 0.0428 0.0922
Trypanosoma brucei transcription elongation factor s-II, putative 0.002 0.0012 0.0015
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0046 0.0133
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0011 0.0002
Trypanosoma brucei calpain-like protein, putative 0.002 0.0013 0.0018
Trypanosoma brucei DNA polymerase kappa, putative 0.0163 0.0473 0.173
Giardia lamblia Kinase, PLK 0.0197 0.0579 0.1656
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0378 0.0812
Echinococcus multilocularis muscleblind protein 0.0612 0.1913 0.4148
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0097 0.0383
Echinococcus granulosus calpain A 0.0071 0.0176 0.0364
Brugia malayi dihydrofolate reductase family protein 0.0755 0.2372 0.3261
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0026
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0083 0.0216 0.0765
Schistosoma mansoni hypothetical protein 0.1248 0.3954 0.8594
Echinococcus multilocularis mitogen activated protein kinase 0.0054 0.0123 0.0249
Brugia malayi CHD4 protein 0.0055 0.0126 0.0161
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0013 0.0003
Plasmodium falciparum DNA repair protein REV1, putative 0.0042 0.0083 0.0278
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0085 0.0166
Trichomonas vaginalis hypothetical protein 0.0034 0.0059 0.0216
Brugia malayi nuclear hormone receptor 0.0019 0.0011 0.0002
Brugia malayi N-terminal motif family protein 0.019 0.0559 0.0759
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.01 0.0269 0.0567
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0041 0.008 0.032
Plasmodium vivax telomerase reverse transcriptase, putative 0.0855 0.2694 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0026
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0022 0.0018 0.0029
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0055 0.016
Loa Loa (eye worm) bromodomain containing protein 0.004 0.0077 0.0307
Loa Loa (eye worm) runx1 0.0059 0.0136 0.0557
Giardia lamblia Kinase, STE STE20 0.0079 0.0201 0.054
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0135 0.0382 0.1594
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0013 0.0003
Trichomonas vaginalis chromobox protein, putative 0.0225 0.0669 0.2894
Trypanosoma brucei phosphoglycerate kinase, putative 0.0064 0.0152 0.0537
Schistosoma mansoni hypothetical protein 0.0302 0.0917 0.1986
Leishmania major telomerase reverse transcriptase, putative 0.0855 0.2694 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0146 0.0417 0.0889
Mycobacterium ulcerans glutaminase 0.0546 0.1701 0.7162
Loa Loa (eye worm) RGS-3 protein 0.0019 0.001 0.0022
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0016 0.0031
Loa Loa (eye worm) inositol-1 0.0039 0.0073 0.0288
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0055 0.02
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.008 0.0098
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0096 0.0255 0.0545
Trypanosoma brucei chrX additional, unordered contigs 0.0042 0.0083 0.0279
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0022 0.0018 0.0058
Loa Loa (eye worm) hypothetical protein 0.0071 0.0175 0.0722
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0034 0.0057 0.0213
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0019 0.0011 0.0013
Loa Loa (eye worm) hypothetical protein 0.0316 0.0963 0.4047
Echinococcus granulosus PWWP domain containing protein 2A 0.002 0.0012 0.0007
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.0406 0.0874
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0023 0.0032
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0045 0.0092 0.0299
Loa Loa (eye worm) hypothetical protein 0.0041 0.008 0.032
Loa Loa (eye worm) hypothetical protein 0.0316 0.0961 0.4042
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0055 0.0126 0.0264
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.008 0.0098
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0026
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0184 0.0539 0.1155
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0041 0.008 0.0165
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.008 0.0156
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0026
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.0406 0.0865
Giardia lamblia Telomerase catalytic subunit 0.0855 0.2694 0.7896
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0039 0.0066
Toxoplasma gondii hypothetical protein 0.002 0.0012 0.0005
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.05 0.1554 0.5769
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.0115 0.039
Brugia malayi latrophilin 2 splice variant baaae 0.0108 0.0295 0.0394
Brugia malayi nuclear receptor NHR-88 0.0019 0.0011 0.0002
Echinococcus multilocularis Chromo domain 0.007 0.0173 0.0357
Brugia malayi regulator of G-protein signaling egl-10 0.0028 0.004 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0097 0.0383
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0285 0.0865 0.318
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0029 0.0067
Entamoeba histolytica hypothetical protein 0.0146 0.0417 0.1199
Trypanosoma brucei phosphoglycerate kinase 0.0173 0.0504 0.1847
Echinococcus multilocularis neuropeptide receptor A26 0.0488 0.1516 0.3283
Toxoplasma gondii exonuclease III APE 0.0057 0.0133 0.0455
Schistosoma mansoni thyroid hormone receptor 0.0041 0.008 0.0165
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.0133 0.0463
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0041 0.008 0.0165
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0015 0.0023
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0046 0.0097 0.033
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0055 0.02
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0055 0.02
Trichomonas vaginalis chromobox protein, putative 0.014 0.0398 0.1702
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0057 0.0133 0.0362
Echinococcus granulosus SAM and MBT domain containing protein 0.01 0.027 0.0569
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0064 0.0152 0.0523
Plasmodium falciparum telomerase reverse transcriptase 0.0855 0.2694 1
Schistosoma mansoni chromobox protein 0.0225 0.0669 0.1446
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0013 0.0003
Brugia malayi CXXC zinc finger family protein 0.012 0.0335 0.045
Leishmania major hypothetical protein, conserved 0.0032 0.005 0.0146
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0036 0.0063 0.0204
Trichomonas vaginalis flap endonuclease-1, putative 0.0107 0.0293 0.1241
Brugia malayi ecdysteroid receptor 0.0041 0.008 0.0098
Loa Loa (eye worm) hypothetical protein 0.0173 0.0504 0.211
Schistosoma mansoni smad1 5 8 and 0.0025 0.0029 0.0054
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0011 0.0004
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0022
Loa Loa (eye worm) hypothetical protein 0.005 0.0109 0.044
Leishmania major importin beta-1 subunit, putative 0.0023 0.0022 0.0043
Trypanosoma brucei DNA polymerase kappa, putative 0.007 0.0174 0.0617
Brugia malayi hypothetical protein 0.0022 0.0018 0.0012
Schistosoma mansoni serine/threonine protein kinase 0.0197 0.0579 0.1251
Leishmania major mitochondrial DNA polymerase beta 0.0603 0.1885 0.6985
Schistosoma mansoni calpain-7 (C02 family) 0.002 0.0013 0.0018
Brugia malayi exodeoxyribonuclease III family protein 0.0057 0.0133 0.017
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0042 0.0127
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0151 0.0618
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0037 0.0068 0.0139
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0042 0.0157
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.05 0.1554 0.5752
Schistosoma mansoni hypothetical protein 0.0043 0.0085 0.0176
Echinococcus granulosus fetal alzheimer antigen falz 0.0052 0.0114 0.0229
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0062 0.0147 0.0502
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0069 0.017 0.0603
Echinococcus multilocularis expressed protein 0.0372 0.1142 0.2468
Entamoeba histolytica hypothetical protein 0.0306 0.0932 0.2716
Echinococcus multilocularis global transcription activator snf2l2 0.0141 0.0403 0.0858
Entamoeba histolytica Flap nuclease, putative 0.0107 0.0293 0.0832
Leishmania major hypothetical protein, conserved 0.0052 0.0115 0.039
Trichomonas vaginalis CAMK family protein kinase 0.0197 0.0579 0.25
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0131 0.0368 0.0367
Brugia malayi Bromodomain containing protein 0.0083 0.0214 0.0282
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0015 0.0023
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0603 0.1885 0.6988
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0055 0.0126 0.0254
Loa Loa (eye worm) hypothetical protein 0.0025 0.0029 0.0102
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0041 0.008 0.0156
Plasmodium vivax DNA (cytosine-5)-methyltransferase, putative 0.0019 0.0011 0.0039
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0027 0.0036 0.006
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0029 0.0086
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0045 0.0092 0.0182
Treponema pallidum fructose-bisphosphate aldolase 0.0306 0.093 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0019 0.0011 0.0013
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0083 0.0264
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.0011 0.0026
Brugia malayi conserved hypotetical protein 0.0019 0.0011 0.0002
Trichomonas vaginalis DNA polymerase eta, putative 0.0163 0.0473 0.2032
Plasmodium falciparum phosphoglycerate kinase 0.0173 0.0504 0.1846
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0013 0.0003
Trypanosoma cruzi kinesin, putative 0.002 0.0013 0.0003
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0069 0.017 0.0595
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.001 0.0002
Echinococcus multilocularis exonuclease 1 0.0022 0.0018 0.0021
Schistosoma mansoni z-protein (S1r protein) 0.0028 0.004 0.0077
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0057 0.0133 0.027
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0057 0.0133 0.027
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.0079 0.0201 0.0706
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0013 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0042 0.014
Schistosoma mansoni flap endonuclease-1 0.0097 0.0259 0.0555
Loa Loa (eye worm) calpain 0.002 0.0013 0.0036
Loa Loa (eye worm) latrophilin receptor protein 2 0.005 0.0109 0.044
Plasmodium falciparum DNA (cytosine-5)-methyltransferase 0.0019 0.0011 0.0008
Brugia malayi ecdysone receptor 0.0019 0.0011 0.0002
Brugia malayi Protein cec-1. 0.0046 0.0097 0.0121
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0046 0.0097 0.0201
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0022
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0069 0.017 0.0595
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.0115 0.0399
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0023 0.0021 0.0034
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0131 0.0368 0.0791
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.019 0.0559 0.0558
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0041 0.008 0.0156
Echinococcus granulosus hepatoma derived growth factor protein 0.002 0.0012 0.0007
Giardia lamblia Phosphoglycerate kinase 0.0173 0.0504 0.1433
Echinococcus multilocularis FTZ F1 alpha 0.0041 0.008 0.0156
Echinococcus multilocularis tar DNA binding protein 0.0134 0.0378 0.0804
Trypanosoma brucei antigen, putative 0.002 0.0013 0.0018
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.0007 0.0005
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0073 0.0272
Brugia malayi Importin beta-1 subunit 0.0028 0.0039 0.0041
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0071 0.0175 0.0363
Schistosoma mansoni hepatoma derived growth factor 0.002 0.0012 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0063 0.0233
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0035 0.0062 0.0185
Schistosoma mansoni inositol monophosphatase 0.0039 0.0073 0.0148
Loa Loa (eye worm) hypothetical protein 0.0108 0.0295 0.1226
Echinococcus granulosus calpain 7 C02 family 0.002 0.0013 0.0009
Onchocerca volvulus Serine\/threonine kinase homolog 0.0197 0.0579 0.0578
Brugia malayi Bloom's syndrome protein homolog 0.0138 0.0391 0.0527
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0306 0.093 0.404
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0074 0.0186 0.0387
Brugia malayi serine/threonine-protein kinase plk-2 0.0197 0.0579 0.0787
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.0115 0.0428
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0603 0.1885 0.6984
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0055 0.02
Onchocerca volvulus 0.0019 0.0011 0.0009
Schistosoma mansoni blooms syndrome DNA helicase 0.0103 0.0278 0.0594
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0296 0.0843
Onchocerca volvulus 0.0028 0.004 0.0038
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0085 0.0221 0.0778
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0063 0.0233
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.001 0.0001
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0088 0.0231 0.0484
Trypanosoma brucei DNA polymerase kappa, putative 0.01 0.027 0.0975
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0066 0.0161 0.0662
Mycobacterium tuberculosis Conserved hypothetical protein 0.0135 0.0382 0.1592
Mycobacterium ulcerans DNA polymerase IV 0.0163 0.0473 0.1965
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.0079 0.0201 0.0265
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0029 0.0067
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.001 0.0002
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0173 0.0504 0.1835
Loa Loa (eye worm) Smad1 0.0025 0.0029 0.0105
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0057 0.0133 0.0542
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0055 0.02
Treponema pallidum phosphoglycerate kinase 0.0173 0.0504 0.5199
Echinococcus multilocularis dna polymerase eta 0.0188 0.0552 0.1183
Schistosoma mansoni retinoic acid receptor RXR 0.0041 0.008 0.0165
Trichomonas vaginalis flap endonuclease-1, putative 0.0022 0.0018 0.0038
Echinococcus granulosus Chromo domain 0.007 0.0173 0.0357
Trypanosoma brucei DNA polymerase eta, putative 0.0188 0.0552 0.2025
Brugia malayi tailless protein 0.0019 0.0011 0.0002
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.001 0.0002
Brugia malayi nuclear hormone receptor 0.0041 0.008 0.0098
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0069 0.017 0.0222
Echinococcus granulosus DNA methyltransferase 2, putative 0.0019 0.0011 0.0004
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0034 0.0057 0.0067
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0097 0.0383
Loa Loa (eye worm) hypothetical protein 0.0028 0.0038 0.0142
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.003 0.0044 0.0124
Schistosoma mansoni Smad4 0.0025 0.0029 0.0054
Trypanosoma brucei ISWI complex protein 0.0032 0.005 0.0155
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0041 0.008 0.0098
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.001 0.0012
Schistosoma mansoni inositol monophosphatase 0.0039 0.0073 0.0148
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0046 0.0097 0.0192
Schistosoma mansoni smad 0.0025 0.0029 0.0054
Trypanosoma cruzi DNA repair protein RAD2, putative 0.0022 0.0018 0.0024
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.002 0.0013 0.0018
Echinococcus multilocularis calpain A 0.0071 0.0176 0.0364
Schistosoma mansoni kinase 0.01 0.0271 0.0579
Schistosoma mansoni terminal deoxycytidyl transferase 0.0135 0.0382 0.0821
Schistosoma mansoni cpg binding protein 0.012 0.0335 0.072
Brugia malayi RNA binding protein 0.0134 0.0378 0.0509
Schistosoma mansoni regulator of G protein signaling 0.0028 0.004 0.0077
Mycobacterium ulcerans hypothetical protein 0.0042 0.0083 0.0316
Echinococcus granulosus peregrin 0.0059 0.0137 0.028
Brugia malayi hypothetical protein 0.0062 0.0147 0.019
Plasmodium falciparum exonuclease I, putative 0.0022 0.0018 0.0037
Loa Loa (eye worm) BRM protein 0.0076 0.0191 0.0787
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0012 0.0011
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0073 0.0139
Brugia malayi Phosphoglycerate kinase 0.0173 0.0504 0.0683
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0042 0.0071
Echinococcus multilocularis nuclear receptor nhr 48 0.0019 0.0011 0.0004
Giardia lamblia PHD finger protein 15 0.0031 0.0046 0.0083
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0057 0.0133 0.0337
Schistosoma mansoni regulator of G protein signaling 0.0019 0.001 0.0012
Loa Loa (eye worm) hypothetical protein 0.0047 0.01 0.0406
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0049 0.0106 0.0354
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0054 0.0123 0.042
Entamoeba histolytica hypothetical protein 0.0046 0.0097 0.0257
Trypanosoma brucei DNA polymerase kappa, putative 0.0163 0.0473 0.173
Schistosoma mansoni hypothetical protein 0.005 0.0109 0.0227
Echinococcus multilocularis Smad4 0.0025 0.0029 0.0045
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.001 0.0002
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0055 0.0126 0.0254
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0808 0.2541 0.5515
Trypanosoma brucei DNA polymerase kappa, putative 0.0142 0.0404 0.1476
Schistosoma mansoni hypothetical protein 0.0166 0.0482 0.1039
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0107 0.0293 0.1046
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0045 0.0092 0.0243
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0046 0.0177
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.0055 0.0165
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0028 0.004 0.0149
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0041 0.008 0.0156
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.0133 0.0539
Giardia lamblia Sgs1 DNA helicase, putative 0.0069 0.017 0.0449
Schistosoma mansoni hypothetical protein 0.005 0.0109 0.0227
Echinococcus granulosus 6 phosphofructokinase 0.0108 0.0296 0.0626
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0052 0.0114 0.0238
Loa Loa (eye worm) CXXC zinc finger family protein 0.012 0.0335 0.1397
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.0092 0.037
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0046 0.0133
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0069 0.017 0.0352
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0066 0.0161 0.0662
Schistosoma mansoni SET domain protein 0.0073 0.0184 0.0392
Loa Loa (eye worm) hypothetical protein 0.0069 0.017 0.0701
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.0079 0.0201 0.072
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0046 0.0091
Echinococcus multilocularis ecdysone induced protein 78C 0.0041 0.008 0.0156
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.0296 0.1231
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0012 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0041 0.008 0.032
Loa Loa (eye worm) hypothetical protein 0.024 0.0719 0.3019
Brugia malayi mbt repeat family protein 0.01 0.027 0.036
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0123 0.0498
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0173 0.0504 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0097 0.0391
Trichomonas vaginalis CAMK family protein kinase 0.0197 0.0579 0.25
Trichomonas vaginalis glutaminase, putative 0.0546 0.1701 0.7423
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0057 0.0131 0.0533
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0066 0.0161 0.0662
Brugia malayi 6-phosphofructokinase 0.0108 0.0296 0.0396
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0302 0.0917 0.3855
Echinococcus multilocularis thyroid hormone receptor alpha 0.0041 0.008 0.0156
Brugia malayi calpain family protein 1 0.0067 0.0165 0.0215
Trypanosoma brucei DNA polymerase kappa, putative 0.0163 0.0473 0.173
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.008 0.0156
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.005 0.0109 0.0218
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0041 0.008 0.0098
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.005 0.0109 0.0218
Entamoeba histolytica phosphoglycerate kinase, putative 0.0173 0.0504 0.1455
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0029 0.0105
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0045 0.0092 0.0299
Loa Loa (eye worm) hypothetical protein 0.0067 0.0165 0.0678
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0064 0.0152 0.0528
Schistosoma mansoni xp-G/rad2 DNA repair endonuclease family member 0.0022 0.0018 0.003
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0184 0.0539 0.1155
Echinococcus granulosus dna polymerase kappa 0.0163 0.0473 0.101
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0143 0.0406 0.1697
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0046 0.0097 0.0322
Trichomonas vaginalis flap endonuclease-1, putative 0.0022 0.0018 0.0038
Trichomonas vaginalis lymphoid specific helicase, putative 0.003 0.0044 0.015
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0036 0.0063 0.0195
Loa Loa (eye worm) hypothetical protein 0.0046 0.0097 0.0391
Brugia malayi hypothetical protein 0.0071 0.0175 0.023
Echinococcus multilocularis BRK domain 0.0024 0.0024 0.0034
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0046 0.0097 0.0201
Trypanosoma brucei cytosine-specific DNA methylase, putative 0.0019 0.0011 0.0009
Schistosoma mansoni cpg binding protein 0.0129 0.0364 0.0782
Schistosoma mansoni nuclear receptor 0.0019 0.0011 0.0013
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0023 0.0021 0.0048
Brugia malayi nuclear receptor RXR 0.0019 0.0011 0.0002
Loa Loa (eye worm) helicase DNA-binding protein 0.0024 0.0024 0.0084
Trypanosoma cruzi target of rapamycin kinase 3 0.0036 0.0063 0.0189
Loa Loa (eye worm) heterochromatin protein 1 0.0225 0.0669 0.2808
Plasmodium vivax SET domain protein, putative 0.0096 0.0255 0.0947
Echinococcus granulosus microtubule associated protein 2 0.1449 0.4601 1
Schistosoma mansoni rotamase 0.0034 0.0057 0.0115
Treponema pallidum ATP-dependent DNA helicase 0.0035 0.0062 0.0216
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0041 0.008 0.0156
Loa Loa (eye worm) hypothetical protein 0.0038 0.007 0.0276
Trichomonas vaginalis rotamase, putative 0.0034 0.0057 0.021
Schistosoma mansoni steroid hormone receptor ad4bp 0.0041 0.008 0.0165
Toxoplasma gondii hypothetical protein 0.0083 0.0215 0.0761
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0022
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.001 0.0001
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0173 0.0504 0.1835
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0054 0.0123 0.042
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0197 0.0579 0.1243
Loa Loa (eye worm) hypothetical protein 0.0067 0.0165 0.0678
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0034 0.0108
Schistosoma mansoni hepatoma derived growth factor 0.002 0.0012 0.0017
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0026
Loa Loa (eye worm) hypothetical protein 0.0131 0.0368 0.1538
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0142 0.0404 0.0868
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0042 0.0118
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0069 0.017 0.0701
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0035 0.0062 0.0185
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0011 0.0004
Loa Loa (eye worm) hypothetical protein 0.0612 0.1913 0.8062
Schistosoma mansoni thyroid hormone receptor 0.0041 0.008 0.0165
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0057 0.0133 0.0464
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0021 0.0017 0.0023
Echinococcus granulosus importin subunit beta 1 0.0028 0.0039 0.0066
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0173 0.0504 0.2169
Schistosoma mansoni hypothetical protein 0.007 0.0173 0.0366
Echinococcus granulosus lamin 0.0028 0.004 0.0067
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0055 0.0126 0.0512
Onchocerca volvulus 0.0136 0.0384 0.0383
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0042 0.0118
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.013 0.0365 0.0785
Echinococcus multilocularis peregrin 0.0059 0.0137 0.028
Echinococcus granulosus polycomb protein SCMH1 0.01 0.027 0.0569
Brugia malayi hypothetical protein 0.0022 0.0018 0.0012
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0026
Trypanosoma brucei DNA polymerase kappa, putative 0.01 0.027 0.0975
Echinococcus multilocularis geminin 0.0166 0.0482 0.103
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0033 0.0054 0.0098
Leishmania major DNA polymerase kappa, putative 0.0142 0.0404 0.1468
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0026 0.0071
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0021 0.0015 0.0008
Echinococcus granulosus calpain A 0.002 0.0013 0.0009
Brugia malayi photoreceptor-specific nuclear receptor 0.0041 0.008 0.0098
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0406 0.1253 0.2709
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0012 0.0011
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0064 0.0152 0.0523
Echinococcus multilocularis calpain family protein 1, d 0.0047 0.01 0.02
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0306 0.093 0.271
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0131 0.0368 0.0783
Giardia lamblia Flap structure-specific endonuclease 0.0107 0.0293 0.0809
Brugia malayi MAP kinase sur-1 0.0054 0.0123 0.0157
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0085 0.0221 0.0778
Trichomonas vaginalis set domain proteins, putative 0.0729 0.2288 1
Echinococcus granulosus Chromobox protein 3 0.0046 0.0097 0.0192
Echinococcus multilocularis dual specificity mitogen activated protein 0.0079 0.0201 0.042
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0123 0.0498
Schistosoma mansoni chromobox protein 0.0046 0.0097 0.0201
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.002
Schistosoma mansoni hypothetical protein 0.0108 0.0295 0.0632
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0045 0.0154
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0046 0.0097 0.0383
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0063 0.0233
Onchocerca volvulus 0.0142 0.0404 0.0402
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0296 0.1256
Trypanosoma brucei calpain-like protein, putative 0.002 0.0013 0.0018
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.0406 0.0865
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0088 0.0232 0.0825
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.1077 0.3407 1
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0097 0.0383
Brugia malayi MH2 domain containing protein 0.0025 0.0029 0.0028
Schistosoma mansoni phosphoglycerate kinase 0.0173 0.0504 0.1087
Loa Loa (eye worm) calpain family protein 1 0.0047 0.01 0.0406
Echinococcus granulosus phosphoglycerate kinase 1 0.0173 0.0504 0.1079
Echinococcus multilocularis snurportin 1 0.0302 0.0917 0.1979
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.0406 0.0874
Brugia malayi MH1 domain containing protein 0.0025 0.0029 0.0028
Trypanosoma cruzi DNA damage repair protein, putative 0.0042 0.0083 0.0264
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0135 0.0382 0.0813
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0029 0.0045
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0197 0.0579 0.1243
Leishmania major DNA polymerase eta, putative 0.0188 0.0552 0.2018
Leishmania major DNA damage repair protein, putative 0.0042 0.0083 0.027
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.022 0.0923
Loa Loa (eye worm) hypothetical protein 0.0146 0.0417 0.1742
Schistosoma mansoni hypothetical protein 0.0621 0.1941 0.4212
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0855 0.2694 1
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0069 0.017 0.0352
Loa Loa (eye worm) hypothetical protein 0.0025 0.0029 0.0102
Brugia malayi hypothetical protein 0.0034 0.0056 0.0065
Echinococcus multilocularis chromobox protein 1 0.0225 0.0669 0.1438
Brugia malayi intermediate filament protein 0.0028 0.004 0.0042
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0054 0.0123 0.0502
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0011 0.0013
Trypanosoma cruzi DNA polymerase eta, putative 0.0095 0.0253 0.0899
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0073 0.0276
Brugia malayi MH2 domain containing protein 0.0025 0.0029 0.0028
Echinococcus granulosus tar DNA binding protein 0.0134 0.0378 0.0804
Plasmodium vivax flap endonuclease 1, putative 0.0107 0.0293 0.1086
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0054 0.0123 0.0429
Brugia malayi RNA recognition motif domain containing protein 0.0134 0.0378 0.0509
Loa Loa (eye worm) hypothetical protein 0.0041 0.008 0.032
Brugia malayi MH2 domain containing protein 0.037 0.1136 0.1555
Echinococcus multilocularis thymidylate synthase 0.013 0.0365 0.0776
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0107 0.0293 0.1059
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0135 0.0382 0.0813
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0055 0.02
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0022 0.0054
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0017
Giardia lamblia DNA damage repair protein 0.0042 0.0083 0.0191
Echinococcus multilocularis flap endonuclease GEN 1 0.0022 0.0018 0.0021
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0406 0.1253 0.2709
Mycobacterium ulcerans hypothetical protein 0.0318 0.0968 0.4062
Brugia malayi glutaminase DH11.1 0.0546 0.1701 0.2335
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0045 0.0092 0.0243
Brugia malayi Heterochromatin protein 1 0.0225 0.0669 0.0911
Schistosoma mansoni calpain-7 (C02 family) 0.002 0.0013 0.0018
Toxoplasma gondii histone lysine methyltransferase SET1 0.018 0.0527 0.1923
Trichomonas vaginalis chromobox protein, putative 0.0046 0.0097 0.0383
Loa Loa (eye worm) calpain 5 0.002 0.0013 0.0036
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.0083 0.0279
Echinococcus granulosus zinc finger protein 0.0049 0.0106 0.0211
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0147 0.0601
Trypanosoma cruzi kinesin, putative 0.002 0.0013 0.0003
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.001 0.0002
Echinococcus multilocularis dihydrofolate reductase 0.0755 0.2372 0.5147
Echinococcus multilocularis lamin dm0 0.0028 0.004 0.0067
Brugia malayi Disco-interacting protein 2 homolog 0.0038 0.007 0.0084
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.0406 0.0874
Loa Loa (eye worm) hypothetical protein 0.0028 0.004 0.0149
Brugia malayi Telomerase reverse transcriptase 0.2276 0.7255 1
Onchocerca volvulus 0.0144 0.0412 0.0411
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0042 0.0143
Entamoeba histolytica hypothetical protein 0.002 0.0012 0.0007
Echinococcus granulosus lamin dm0 0.0028 0.004 0.0067
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.005 0.0109 0.0218
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0296 0.0843
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.001 0.0002
Trichomonas vaginalis hypothetical protein 0.0046 0.0097 0.0383
Brugia malayi PHD-finger family protein 0.0031 0.0046 0.0051
Loa Loa (eye worm) PHD-finger family protein 0.0043 0.0085 0.0341
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0042 0.0118
Onchocerca volvulus 0.0094 0.0249 0.0248
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0019 0.0011 0.0026
Schistosoma mansoni bromodomain containing protein 0.0139 0.0395 0.085
Brugia malayi ImpB/MucB/SamB family protein 0.0135 0.0382 0.0514
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0041 0.008 0.0098
Brugia malayi bZIP transcription factor family protein 0.0184 0.0539 0.0731
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0096 0.0255 0.0537
Onchocerca volvulus 0.013 0.0365 0.0364
Trypanosoma brucei unspecified product 0.0093 0.0247 0.0891
Schistosoma mansoni hypothetical protein 0.0033 0.0053 0.0106
Plasmodium falciparum DEAD/DEAH box helicase, putative 0.0021 0.0017 0.0031
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0092 0.0115
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0041 0.008 0.0098
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.01 0.0269 0.0567
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.009 0.0236 0.0503
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0033 0.0055 0.0133
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0306 0.093 0.404
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0149 0.0428 0.1705
Schistosoma mansoni lamin 0.0028 0.004 0.0077
Loa Loa (eye worm) BRM protein 0.0087 0.0228 0.0946
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0123 0.0415
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.008 0.0165
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0073 0.0139
Echinococcus granulosus regulator of G protein signaling 7 0.0028 0.004 0.0068
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0017
Echinococcus multilocularis beta adrenergic receptor kinase 0.0021 0.0015 0.0013
Echinococcus multilocularis hypothetical protein 0.002 0.0013 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.008 0.0098
Loa Loa (eye worm) hypothetical protein 0.0046 0.0097 0.0391
Echinococcus granulosus GPCR family 2 0.005 0.0109 0.0218
Onchocerca volvulus 0.01 0.027 0.0269
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0029 0.0027
Trypanosoma brucei calpain-like protein, putative 0.002 0.0013 0.0018
Brugia malayi MH1 domain containing protein 0.0025 0.0029 0.0028
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0041 0.008 0.0156
Schistosoma mansoni regulator of G protein signaling 0.0019 0.001 0.0012
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0017
Entamoeba histolytica hypothetical protein 0.0023 0.0022 0.0036
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0073 0.0231
Trichomonas vaginalis CAMK family protein kinase 0.0197 0.0579 0.25
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0855 0.2694 1
Trypanosoma brucei kinesin, putative 0.002 0.0013 0.0018
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0306 0.0932 0.2716
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0041 0.008 0.032
Entamoeba histolytica exonuclease, putative 0.0022 0.0018 0.0025
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0262 0.1109
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0029 0.0056
Trypanosoma brucei DNA polymerase IV, putative 0.0163 0.0473 0.173
Brugia malayi XPG I-region family protein 0.0022 0.0018 0.0013
Echinococcus multilocularis dna polymerase kappa 0.0163 0.0473 0.101
Echinococcus multilocularis chromobox protein 1 0.0225 0.0669 0.1438
Echinococcus multilocularis polycomb protein SCMH1 0.01 0.027 0.0569
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0158 0.0455 0.0615
Mycobacterium tuberculosis Conserved hypothetical protein 0.0318 0.0968 0.407
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0085 0.0221 0.0778
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0083 0.0216 0.0774
Loa Loa (eye worm) hypothetical protein 0.0188 0.0552 0.2313
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0603 0.1885 0.6984
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.0296 0.1059
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.006 0.023
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0064 0.0152 0.0523
Echinococcus multilocularis chromodomain helicase DNA binding protein 7 0.0024 0.0024 0.0034
Mycobacterium ulcerans DNA polymerase IV 0.0163 0.0473 0.1965
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0018 0.0024
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.0133 0.0492
Loa Loa (eye worm) intermediate filament protein 0.0028 0.004 0.0149
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0026
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0029 0.0027
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0057 0.0133 0.045
Echinococcus multilocularis bloom syndrome protein 0.0138 0.0391 0.0832
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.009 0.0236 0.0877
Echinococcus granulosus chromobox protein 1 0.0225 0.0669 0.1438
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0108 0.0296 0.2856
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0033 0.0104
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0057 0.0133 0.0455
Trichomonas vaginalis DNA helicase recq1, putative 0.0138 0.0391 0.1672
Loa Loa (eye worm) PWWP domain-containing protein 0.002 0.0012 0.0032
Echinococcus multilocularis musashi 0.0028 0.004 0.0067
Loa Loa (eye worm) hypothetical protein 0.007 0.0174 0.0716
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0046 0.0097 0.0322
Brugia malayi calpain family protein 1 0.0067 0.0165 0.0215
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0041 0.008 0.0165
Plasmodium falciparum heterochromatin protein 1 0.0046 0.0097 0.033
Leishmania major dihydrofolate reductase-thymidylate synthase 0.05 0.1554 0.5752
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0046 0.0097 0.0192
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.006 0.0132
Brugia malayi Bromodomain containing protein 0.0039 0.0074 0.0089
Echinococcus granulosus nuclear receptor nhr 48 0.0019 0.0011 0.0004
Echinococcus granulosus Ankyrin repeat domain containing protein 0.009 0.0236 0.0494
Echinococcus granulosus methyl CpG binding domain protein 2 0.0035 0.0061 0.0115
Echinococcus granulosus chromobox protein 2 0.0046 0.0097 0.0192
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0071 0.0176 0.0364
Brugia malayi Amyloid A4 extracellular domain containing protein 0.0305 0.0927 0.1266
Entamoeba histolytica exonuclease, putative 0.0022 0.0018 0.0025
Brugia malayi Steroid receptor seven-up type 2 0.0041 0.008 0.0098
Loa Loa (eye worm) transcription factor SMAD2 0.037 0.1136 0.4779
Trypanosoma cruzi ISWI complex protein 0.0032 0.005 0.0141
Brugia malayi Pre-SET motif family protein 0.0641 0.2006 0.2756
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0073 0.0185
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0042 0.0144
Brugia malayi BRM protein 0.0141 0.0403 0.0543
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0026 0.0071
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.009 0.0236 0.0494
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0069 0.017 0.0222
Echinococcus multilocularis BRK domain containing protein 0.0024 0.0024 0.0034
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0755 0.2372 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.008 0.0098
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0073 0.024
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.0055 0.0174
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0012 0.0011
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0029 0.0056
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.004 0.0149
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0035 0.0061 0.0115
Plasmodium vivax phosphoglycerate kinase, putative 0.0173 0.0504 0.1871
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0026
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0064 0.0152 0.0523
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0019 0.0011 0.0004
Brugia malayi polk-prov protein 0.007 0.0174 0.0227
Treponema pallidum exodeoxyribonuclease (exoA) 0.0057 0.0133 0.1017
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0173 0.0504 0.1839
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0073 0.0226
Schistosoma mansoni DNA helicase recq5 0.0069 0.017 0.0361
Loa Loa (eye worm) hypothetical protein 0.0612 0.1913 0.8062
Echinococcus granulosus mitogen activated protein kinase 3 0.0054 0.0123 0.0249
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0378 0.0812
Loa Loa (eye worm) hypothetical protein 0.0136 0.0384 0.1604
Trichomonas vaginalis STE family protein kinase 0.0079 0.0201 0.0841
Onchocerca volvulus Bile acid receptor homolog 0.0041 0.008 0.0079
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0027 0.0036 0.006
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.0073 0.0184 0.0382
Echinococcus granulosus dihydrofolate reductase 0.0755 0.2372 0.5147
Toxoplasma gondii RNA-directed DNA polymerase 0.0855 0.2694 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0041 0.008 0.0156
Entamoeba histolytica hypothetical protein 0.0146 0.0417 0.1199
Trichomonas vaginalis CAMK family protein kinase 0.0197 0.0579 0.25
Plasmodium vivax calpain, putative 0.002 0.0013 0.0048
Loa Loa (eye worm) MBCTL1 0.0114 0.0315 0.131
Trypanosoma cruzi calpain cysteine peptidase, putative 0.002 0.0013 0.0003
Loa Loa (eye worm) hypothetical protein 0.0136 0.0384 0.1604
Echinococcus granulosus dna polymerase eta 0.0188 0.0552 0.1183
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0022
Echinococcus granulosus BRK domain containing protein 0.0024 0.0024 0.0034
Echinococcus multilocularis expressed protein 0.0034 0.0057 0.0106
Loa Loa (eye worm) hypothetical protein 0.0114 0.0315 0.131
Loa Loa (eye worm) hypothetical protein 0.0467 0.1446 0.609
Schistosoma mansoni tsg101-related 0.0059 0.0138 0.029
Schistosoma mansoni transcription factor LCR-F1 0.0146 0.0417 0.0898
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0019 0.0011 0.0004
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0042 0.0157
Brugia malayi PXA domain containing protein 0.0019 0.001 0.0001
Plasmodium falciparum phd finger protein, putative 0.0031 0.0046 0.0142
Schistosoma mansoni lamin 0.0028 0.004 0.0077
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0011 0.0004
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0173 0.0504 0.1839
Brugia malayi hypothetical protein 0.0019 0.001 0.0001
Loa Loa (eye worm) glutaminase 0.0546 0.1701 0.7166
Brugia malayi hypothetical protein 0.0467 0.1446 0.1984
Echinococcus multilocularis phosphoglycerate kinase 1 0.0173 0.0504 0.1079
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0285 0.0865 0.319
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0306 0.093 0.404
Trichomonas vaginalis flap endonuclease-1, putative 0.0022 0.0018 0.0038
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0149 0.0428 0.1776
Loa Loa (eye worm) hypothetical protein 0.0131 0.0368 0.1536
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0029 0.0056
Echinococcus granulosus muscleblind protein 0.0612 0.1913 0.4148
Loa Loa (eye worm) hypothetical protein 0.0088 0.023 0.0952
Echinococcus multilocularis Protein lozenge 0.0059 0.0136 0.0278
Giardia lamblia DNA repair protein RAD52 0.1077 0.3407 1
Trichomonas vaginalis STE family protein kinase 0.0079 0.0201 0.0841
Schistosoma mansoni nuclear receptor 0.0019 0.0011 0.0013
Trichomonas vaginalis Heterochromatin protein, putative 0.0046 0.0097 0.0383
Echinococcus granulosus flap endonuclease GEN 1 0.0022 0.0018 0.0021
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0306 0.093 0.404
Loa Loa (eye worm) hypothetical protein 0.0041 0.008 0.032
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0013 0.0008
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0057 0.0133 0.045
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.001 0.0022
Mycobacterium tuberculosis Hypothetical protein 0.0062 0.0147 0.0598
Brugia malayi ImpB/MucB/SamB family protein 0.0188 0.0552 0.0749
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0092 0.0362
Onchocerca volvulus 0.002 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0041 0.008 0.032
Brugia malayi nuclear hormone receptor family member nhr-6 0.0019 0.0011 0.0002
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0046 0.0097 0.033
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0046 0.0097 0.0257
Leishmania major ATP-dependent phosphofructokinase 0.0108 0.0296 0.1064
Schistosoma mansoni Mername-AA248 (C02 family) 0.002 0.0013 0.0018
Loa Loa (eye worm) MH2 domain-containing protein 0.037 0.1136 0.4779
Schistosoma mansoni helicase 0.0141 0.0403 0.0866
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0026
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.013 0.0365 0.1521
Onchocerca volvulus Protein ultraspiracle homolog 0.0041 0.008 0.0079
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.001 0.0012
Giardia lamblia Fructose-bisphosphate aldolase 0.0306 0.093 0.2692
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0046 0.0097 0.0383
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0123 0.0259
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0173 0.0504 0.2169
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0029 0.0045
Loa Loa (eye worm) hypothetical protein 0.0129 0.0363 0.1513
Brugia malayi hypothetical protein 0.0019 0.0011 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0097 0.0383
Trypanosoma cruzi DNA polymerase kappa, putative 0.0163 0.0473 0.1718
Entamoeba histolytica recQ family helicase, putative 0.0083 0.0216 0.0607
Schistosoma mansoni jun-related protein 0.0149 0.0428 0.0922
Onchocerca volvulus 0.0028 0.004 0.0038
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0029 0.0086
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0071 0.0176 0.0373
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.0073 0.0184 0.0382
Leishmania major hypothetical protein, conserved 0.0023 0.0021 0.0039
Trichomonas vaginalis chromobox protein, putative 0.0225 0.0669 0.2894
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0026 0.0072
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0039 0.0116
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.0296 0.1231
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0115 0.0398
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0123 0.0498
Loa Loa (eye worm) hypothetical protein 0.0041 0.008 0.032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0034 0.0108
Plasmodium vivax DEAD/DEAH helicase, putative 0.0021 0.0017 0.0062
Echinococcus granulosus Smad4 0.0025 0.0029 0.0045
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0048 0.0103 0.0274
Echinococcus granulosus geminin 0.0166 0.0482 0.103
Schistosoma mansoni chromobox protein 0.0046 0.0097 0.0201
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0142 0.0404 0.1687
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0755 0.2372 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0057 0.0133 0.0539
Echinococcus granulosus bloom syndrome protein 0.0138 0.0391 0.0832
Onchocerca volvulus 0.0019 0.0011 0.0009
Echinococcus multilocularis neuropeptide s receptor 0.0488 0.1516 0.3283
Echinococcus granulosus mitogen activated protein kinase 0.0054 0.0123 0.0249
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0057 0.0133 0.0526
Schistosoma mansoni DNA polymerase eta 0.0188 0.0552 0.1192
Trichomonas vaginalis flap endonuclease-1, putative 0.0022 0.0018 0.0038
Echinococcus multilocularis BRK domain containing protein 0.0024 0.0024 0.0034
Schistosoma mansoni zinc finger protein 0.0019 0.0011 0.0013
Brugia malayi chromobox protein homolog 3 0.0131 0.0368 0.0496
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.0011 0.0009
Brugia malayi PWWP domain containing protein 0.002 0.0012 0.0004
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0029 0.0067
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0066 0.0161 0.0662
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0296 0.0843
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0029 0.0086
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.0032
Schistosoma mansoni calpain C (C02 family) 0.002 0.0013 0.0018
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.008 0.0098
Echinococcus multilocularis calpain 7 (C02 family) 0.002 0.0013 0.0009
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0095 0.0253 0.0904
Brugia malayi Calcitonin receptor-like protein seb-1 0.0158 0.0455 0.0615
Trichomonas vaginalis conserved hypothetical protein 0.0131 0.0368 0.1574
Trypanosoma brucei DNA polymerase kappa, putative 0.0163 0.0473 0.173
Trypanosoma brucei DNA repair protein RAD2, putative 0.0022 0.0018 0.0038
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0029 0.0099
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0022 0.0037
Echinococcus multilocularis hepatoma derived growth factor protein 0.002 0.0012 0.0007
Plasmodium falciparum importin beta, putative 0.0028 0.0039 0.0115
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0142 0.0404 0.1468
Schistosoma mansoni chromobox protein 0.0225 0.0669 0.1446
Loa Loa (eye worm) hypothetical protein 0.0041 0.008 0.032
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0146 0.0417 0.0889
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0103 0.028 0.1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0013 0.0003
Schistosoma mansoni smad1 5 8 and 0.0025 0.0029 0.0054
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0061 0.0124
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0124 0.0345 0.1254
Trypanosoma brucei DNA polymerase kappa, putative 0.0163 0.0473 0.173
Onchocerca volvulus 0.0729 0.2288 0.2287
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0029 0.0027
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0033 0.0054 0.0098
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.0018 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.007 0.0174 0.0617
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0026 0.0072
Trichomonas vaginalis DNA helicase recq, putative 0.0138 0.0391 0.1672
Echinococcus granulosus axis inhibition protein axin 0.0019 0.001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0046 0.0097 0.0391
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0022 0.0018 0.003
Echinococcus granulosus mixed lineage leukemia protein mll 0.0027 0.0036 0.006
Schistosoma mansoni ap endonuclease 0.0057 0.0133 0.0279
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0029 0.0045
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.05 0.1554 0.575
Schistosoma mansoni zinc finger protein 0.0049 0.0106 0.022
Echinococcus granulosus snurportin 1 0.0302 0.0917 0.1979
Echinococcus granulosus DNA repair protein complementing XP G cells 0.0022 0.0018 0.0021
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0029 0.0045
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0158 0.0455 0.1903
Leishmania major kinesin, putative 0.002 0.0013 0.0008
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0018 0.003
Loa Loa (eye worm) TAR-binding protein 0.0134 0.0378 0.1577
Brugia malayi hypothetical protein 0.0146 0.0417 0.0563
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0029 0.0099
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.008 0.0098
Echinococcus multilocularis smad 0.0025 0.0029 0.0045
Plasmodium falciparum DNA repair protein RAD2, putative 0.0022 0.0018 0.0037
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0022
Echinococcus granulosus intermediate filament protein 0.0028 0.004 0.0067
Onchocerca volvulus 0.0047 0.01 0.0099
Schistosoma mansoni hypothetical protein 0.0023 0.0023 0.0041
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0042 0.0143
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0083 0.0215 0.0769
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0114 0.0315 0.0421
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0012 0.0011
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0149 0.0428 0.1787
Echinococcus granulosus neuropeptide s receptor 0.0488 0.1516 0.3283
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0306 0.093 0.404
Schistosoma mansoni hypothetical protein 0.005 0.0109 0.0227
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0306 0.093 0.271
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0306 0.093 0.404
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0012 0.0011
Onchocerca volvulus 0.0038 0.007 0.0068
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0046 0.0082
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0096 0.0255 0.0911
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0055 0.02
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0055 0.0167
Trypanosoma brucei DNA polymerase kappa, putative 0.0163 0.0473 0.173
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0022 0.0018 0.0029
Echinococcus multilocularis Chromobox protein 3 0.0046 0.0097 0.0192
Schistosoma mansoni hypothetical protein 0.0031 0.0046 0.0091
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0067 0.0127
Loa Loa (eye worm) hypothetical protein 0.0035 0.0062 0.0241
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.022 0.0923
Loa Loa (eye worm) hypothetical protein 0.0179 0.0523 0.2189
Loa Loa (eye worm) calpain family protein 1 0.0067 0.0165 0.0678
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0262 0.1109
Loa Loa (eye worm) hypothetical protein 0.0022 0.0018 0.0059
Schistosoma mansoni xp-G/rad2 DNA repair endonuclease family 0.0022 0.0018 0.003
Loa Loa (eye worm) DR-78 0.0019 0.0011 0.0026
Brugia malayi Phosphoglycerate kinase 0.0064 0.0152 0.0198

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) = 6.93 Inhibitory activity against dihydrofolate reductase ChEMBL. 11495588
Activity (binding) = 6.93 Activity against dihydrofolate reductase of Escherichia coli strain MB 1428 ChEMBL. 1507206
clogP = 3.479 Calculated partition coefficient (clogP) ChEMBL. 8941396
IC50 (binding) = 6.4 Compound was tested for inhibition of E. coli Dihydrofolate reductase. ChEMBL. 8941396
Ki (binding) = 5.26 Inhibitory activity against chicken liver dihydrofolate reductase ChEMBL. 2502631
Ki (binding) = 6.41 Inhibitory activity against Lactobacillus casei dihydrofolate reductase ChEMBL. 2502631
Ki (binding) = 6.93 Inhibitory activity against E. coli dihydrofolate reductase ChEMBL. 1899453
Log (binding) = 6.4 1/IC50 Compound was tested for inhibition of E. coli Dihydrofolate reductase. ChEMBL. 8941396
Log (binding) = 6.93 1/Ki Inhibitory activity against E. coli dihydrofolate reductase ChEMBL. 1899453
Log 1/Ki (binding) = 5.26 Inhibitory activity against chicken liver dihydrofolate reductase ChEMBL. 2502631
Log 1/Ki (binding) = 6.41 Inhibitory activity against Lactobacillus casei dihydrofolate reductase ChEMBL. 2502631
logD (ADMET) = 0.98 Partition coefficient (logD) (aqueous phase 0.1 N HCl) ChEMBL. 2502631

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

5 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.