Detailed information for compound 831372

Basic information

Technical information
  • TDR Targets ID: 831372
  • Name: N-(4-acetylphenyl)-2-[[4-(4-fluorophenyl)-5-[ (1-methylpyrrol-2-yl)methyl]-1,2,4-triazol-3- yl]sulfanyl]acetamide
  • MW: 463.527 | Formula: C24H22FN5O2S
  • H donors: 1 H acceptors: 4 LogP: 3.35 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(cc1)C(=O)C)CSc1nnc(n1c1ccc(cc1)F)Cc1cccn1C
  • InChi: 1S/C24H22FN5O2S/c1-16(31)17-5-9-19(10-6-17)26-23(32)15-33-24-28-27-22(14-21-4-3-13-29(21)2)30(24)20-11-7-18(25)8-12-20/h3-13H,14-15H2,1-2H3,(H,26,32)
  • InChiKey: ATBQWDYKYNCFOG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(4-acetylphenyl)-2-[[4-(4-fluorophenyl)-5-[(1-methyl-2-pyrrolyl)methyl]-1,2,4-triazol-3-yl]thio]acetamide
  • N-(4-acetylphenyl)-2-[[4-(4-fluorophenyl)-5-[(1-methylpyrrol-2-yl)methyl]-1,2,4-triazol-3-yl]thio]acetamide
  • N-(4-ethanoylphenyl)-2-[[4-(4-fluorophenyl)-5-[(1-methylpyrrol-2-yl)methyl]-1,2,4-triazol-3-yl]sulfanyl]ethanamide
  • MLS000118744
  • SMR000095684
  • MLS000878615

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Schistosoma mansoni Thioredoxin glutathione reductase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Thioredoxin glutathione reductase   598 aa 533 aa 50.8 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin glutathione reductase   598 aa 513 aa 25.0 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin glutathione reductase   598 aa 512 aa 28.3 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 518 aa 22.0 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Neospora caninum hypothetical protein Thioredoxin glutathione reductase   598 aa 485 aa 30.5 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin glutathione reductase   598 aa 537 aa 24.2 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin glutathione reductase   598 aa 555 aa 33.5 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 538 aa 25.3 %
Neospora caninum glutathione reductase, putative Thioredoxin glutathione reductase   598 aa 532 aa 34.6 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 521 aa 21.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0027 0.0016 0.0095
Echinococcus granulosus caspase 2 0.0031 0.0021 0.0048
Trypanosoma cruzi histone deacetylase, putative 0.0044 0.004 0.0095
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0034 0.0026 0.006
Loa Loa (eye worm) hypothetical protein 0.0243 0.0313 0.08
Plasmodium falciparum ataxin-2 like protein, putative 0.0075 0.0081 0.0839
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0027 0.0016 0.0033
Schistosoma mansoni cathepsin C 0.0243 0.0313 0.0799
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0108 0.0127 0.0322
Brugia malayi beta-lactamase family protein 0.0026 0.0014 0.0031
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0027 0.0015 0.0023
Brugia malayi cathepsin Z-like cysteine proteinase 0.0243 0.0313 0.0799
Leishmania major importin beta-1 subunit, putative 0.0051 0.0049 0.0326
Loa Loa (eye worm) hypothetical protein 0.0051 0.0048 0.012
Trichomonas vaginalis glutathione reductase, putative 0.0027 0.0016 0.0115
Trichomonas vaginalis glucosylceramidase, putative 0.0128 0.0155 0.1089
Entamoeba histolytica cysteine protease, putative 0.0294 0.0382 0.3915
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0721 0.097 0.2492
Plasmodium vivax unspecified product 0.0243 0.0313 0.3224
Brugia malayi nuclear receptor NHR-88 0.0033 0.0023 0.0055
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0039 0.0032 0.0077
Toxoplasma gondii exonuclease III APE 0.0027 0.0015 0.0087
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0034 0.0026 0.006
Loa Loa (eye worm) cysteine protease 0.0721 0.097 0.2492
Echinococcus multilocularis survival motor neuron protein 1 0.1252 0.1699 0.302
Onchocerca volvulus 0.0037 0.003 0.0265
Entamoeba histolytica hypothetical protein 0.0243 0.0313 0.3191
Schistosoma mansoni chromobox protein 0.0039 0.0032 0.0076
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0047 0.0043 0.0072
Mycobacterium tuberculosis Conserved protein 0.0026 0.0014 0.001
Brugia malayi Niemann-Pick C1 protein precursor 0.0306 0.0399 0.1022
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2844 0.3886 1
Schistosoma mansoni transcription factor LCR-F1 0.0139 0.017 0.0431
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0243 0.0313 0.2204
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0057 0.0057 0.0141
Brugia malayi Pax transcription activation domain interacting protein 0.0052 0.005 0.0122
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0243 0.0313 0.2204
Schistosoma mansoni hypothetical protein 0.0565 0.0756 0.194
Brugia malayi hypothetical protein 0.0048 0.0045 0.011
Brugia malayi Patched protein homolog 1 0.0019 0.0004 0.0005
Echinococcus granulosus pyruvate kinase 0.0026 0.0014 0.003
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0037 0.003 0.0069
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0034 0.0025 0.004
Schistosoma mansoni jumonji/arid domain-containing protein 0.0051 0.0048 0.0119
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0181 0.0227 0.061
Entamoeba histolytica acyl-coA synthetase, putative 0.0127 0.0153 0.1534
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0856 0.1154 0.2965
Mycobacterium ulcerans aldehyde dehydrogenase 0.0139 0.017 0.2302
Brugia malayi Pyruvate kinase, M2 isozyme 0.005 0.0047 0.0116
Brugia malayi fibroinase precursor 0.0243 0.0313 0.0799
Brugia malayi CXXC zinc finger family protein 0.0041 0.0035 0.0085
Brugia malayi Protein kinase domain containing protein 0.0018 0.0003 0.0002
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0057 0.0057 0.0141
Schistosoma mansoni thyroid hormone receptor 0.0033 0.0023 0.0055
Loa Loa (eye worm) hypothetical protein 0.0033 0.0023 0.0056
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0195 0.0247 0.063
Plasmodium falciparum serine repeat antigen 4 0.0243 0.0313 0.3224
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0243 0.0313 0.3224
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0306 0.0399 0.4086
Schistosoma mansoni pyruvate kinase 0.005 0.0047 0.0116
Trypanosoma cruzi cysteine peptidase, putative 0.0294 0.0382 0.0977
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0243 0.0313 0.2204
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0343 0.045 0.4271
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0057 0.0057 0.0141
Schistosoma mansoni calpain-7 (C02 family) 0.0026 0.0014 0.0031
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0037 0.003 0.0049
Giardia lamblia Cysteine protease 0.0243 0.0313 0.2179
Brugia malayi beta-lactamase 0.0026 0.0014 0.0031
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0243 0.0313 0.2204
Echinococcus multilocularis pyruvate kinase 0.005 0.0047 0.008
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0037 0.003 0.0348
Schistosoma mansoni hypothetical protein 0.0063 0.0064 0.016
Trichomonas vaginalis ran, putative 0.0047 0.0043 0.0299
Schistosoma mansoni intermediate filament proteins 0.0081 0.009 0.0226
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.2844 0.3886 1
Schistosoma mansoni survival motor neuron protein 0.0255 0.033 0.0843
Echinococcus multilocularis snurportin 1 0.0675 0.0906 0.1608
Brugia malayi Bromodomain containing protein 0.0043 0.0037 0.009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.067 0.09 0.6347
Leishmania major cathepsin L-like protease 0.0721 0.097 0.6833
Loa Loa (eye worm) hypothetical protein 0.0161 0.02 0.0509
Trichomonas vaginalis penicillin-binding protein, putative 0.0026 0.0014 0.0101
Mycobacterium tuberculosis Conserved protein 0.0026 0.0014 0.001
Echinococcus granulosus calpain A 0.0057 0.0057 0.0141
Giardia lamblia Cathepsin B precursor 0.0243 0.0313 0.2179
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.004 0.0034 0.0081
Echinococcus multilocularis cysteine protease 0.0721 0.097 0.1722
Brugia malayi hypothetical protein 0.0052 0.005 0.0122
Loa Loa (eye worm) hypothetical protein 0.0052 0.005 0.0123
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0033 0.0023 0.0055
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0033 0.0023 0.0055
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0027 0.0016 0.0092
Trichomonas vaginalis glucosylceramidase, putative 0.0195 0.0247 0.174
Leishmania major 4-coumarate:coa ligase-like protein 0.0127 0.0153 0.1059
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0027 0.0016 0.0082
Trypanosoma brucei recA bacterial DNA recombination protein, putative 0.0097 0.0112 0.076
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0037 0.003 0.0348
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0063 0.0064 0.0111
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0027 0.0016 0.0035
Loa Loa (eye worm) calpain 0.0021 0.0007 0.0013
Mycobacterium ulcerans acyl-CoA synthetase 0.0037 0.003 0.0348
Onchocerca volvulus Protein patched homolog 0.0019 0.0004 0.0021
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0243 0.0313 0.0799
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0007 0.001
Plasmodium vivax patched family protein, putative 0.0019 0.0004 0.0042
Plasmodium vivax ataxin-2 like protein, putative 0.0075 0.0081 0.0839
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0007 0.0015
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0052 0.005 0.0351
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0294 0.0382 0.2697
Echinococcus multilocularis peregrin 0.0043 0.0037 0.0062
Trypanosoma cruzi cysteine protease, putative 0.0294 0.0382 0.0977
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0907 0.1224 0.8631
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0006
Loa Loa (eye worm) pyruvate kinase 0.005 0.0047 0.0117
Echinococcus granulosus jumonji domain containing protein 0.0056 0.0055 0.0136
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0721 0.097 0.684
Onchocerca volvulus 0.0721 0.097 0.9236
Loa Loa (eye worm) CXXC zinc finger family protein 0.0041 0.0035 0.0086
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.014 0.0354
Echinococcus multilocularis caspase 2 0.0031 0.0021 0.0033
Schistosoma mansoni lozenge 0.0098 0.0113 0.0285
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0011 0.0074
Echinococcus multilocularis thioredoxin glutathione reductase 0.008 0.0088 0.0153
Entamoeba histolytica cysteine protease, putative 0.0294 0.0382 0.3915
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0033 0.0023 0.0055
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0027 0.0016 0.0082
Loa Loa (eye worm) hypothetical protein 0.0113 0.0134 0.0341
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0243 0.0313 0.08
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0018 0.0003 0.003
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0034 0.0026 0.0058
Echinococcus multilocularis calpain family protein 1, d 0.004 0.0034 0.0056
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0006
Onchocerca volvulus 0.0041 0.0035 0.0317
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0027 0.0016 0.0116
Echinococcus granulosus survival motor neuron protein 1 0.1252 0.1699 0.4369
Onchocerca volvulus 0.0052 0.005 0.0457
Toxoplasma gondii hypothetical protein 0.0067 0.0071 0.0483
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.005 0.0351
Schistosoma mansoni hypothetical protein 0.0018 0.0003 0.0002
Onchocerca volvulus 0.0721 0.097 0.9236
Schistosoma mansoni RAR-like nuclear receptor 0.0033 0.0023 0.0055
Plasmodium falciparum phd finger protein, putative 0.004 0.0034 0.0346
Treponema pallidum NADH oxidase 0.0027 0.0016 0.0015
Brugia malayi AMP-binding enzyme family protein 0.0037 0.003 0.0071
Schistosoma mansoni hypothetical protein 0.0565 0.0756 0.194
Giardia lamblia Replication factor C, subunit 1 0.0052 0.005 0.0319
Loa Loa (eye worm) hypothetical protein 0.0113 0.0134 0.0341
Onchocerca volvulus 0.0019 0.0004 0.0021
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0243 0.0313 0.08
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.003 0.0025
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0027 0.0016 0.0079
Loa Loa (eye worm) runx1 0.0098 0.0113 0.0286
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.4107 0.5621 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0243 0.0313 0.2179
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0033 0.0023 0.0038
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0063 0.0064 0.0111
Treponema pallidum recombinase A 0.0316 0.0412 0.561
Loa Loa (eye worm) hypothetical protein 0.0131 0.0159 0.0404
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.005 0.0351
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0023 0.0011 0.0021
Plasmodium falciparum serine repeat antigen 9 0.0243 0.0313 0.3224
Plasmodium falciparum glutathione reductase 0.0079 0.0087 0.0902
Trypanosoma cruzi cruzipain precursor, putative 0.0051 0.0048 0.0117
Brugia malayi Patched family protein 0.0019 0.0004 0.0005
Brugia malayi hypothetical protein 0.0075 0.0081 0.0204
Brugia malayi Cathepsin L-like precursor 0.0721 0.097 0.2491
Brugia malayi Calcitonin receptor-like protein seb-1 0.0198 0.025 0.0638
Brugia malayi Latrophilin receptor protein 2 0.0063 0.0064 0.016
Onchocerca volvulus 0.0081 0.009 0.084
Onchocerca volvulus Bile acid receptor homolog 0.0033 0.0023 0.0206
Entamoeba histolytica cysteine proteinase, putative 0.067 0.09 0.9276
Loa Loa (eye worm) patched family protein 0.0019 0.0004 0.0006
Brugia malayi RNA, U transporter 1 0.018 0.0226 0.0575
Brugia malayi intermediate filament protein 0.0081 0.009 0.0226
Toxoplasma gondii aldehyde dehydrogenase 0.0139 0.017 0.1181
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.005 0.0047 0.0116
Entamoeba histolytica cysteine proteinase 1, putative 0.0294 0.0382 0.3915
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0034 0.0026 0.018
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.1047 0.1418 1
Trichomonas vaginalis conserved hypothetical protein 0.0243 0.0313 0.2204
Mycobacterium tuberculosis Probable hydrolase 0.0026 0.0014 0.001
Onchocerca volvulus 0.0019 0.0004 0.0021
Trichomonas vaginalis chromobox protein, putative 0.0039 0.0032 0.0223
Echinococcus multilocularis pyruvate kinase 0.005 0.0047 0.008
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0057 0.0057 0.0097
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0037 0.003 0.0348
Loa Loa (eye worm) hypothetical protein 0.2844 0.3886 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0016 0.0034
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0243 0.0313 0.0799
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0001
Echinococcus multilocularis expressed conserved protein 0.0287 0.0374 0.0661
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.005 0.0047 0.0116
Giardia lamblia Cathepsin L-like protease 0.0243 0.0313 0.2179
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0127 0.0153 0.206
Echinococcus granulosus beta LACTamase domain containing family member 0.0026 0.0014 0.0031
Leishmania major GTP-binding protein, putative 0.0047 0.0043 0.028
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.009 0.0102 0.0097
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0037 0.003 0.0044
Echinococcus granulosus dnaJ subfamily B 0.0296 0.0385 0.0986
Brugia malayi prolyl oligopeptidase family protein 0.0027 0.0016 0.0035
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0027 0.0016 0.0035
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.0316 0.0412 0.1142
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0243 0.0313 0.2204
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0016 0.0034
Brugia malayi cathepsin L precursor 0.0243 0.0313 0.0799
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.0168 0.0296
Entamoeba histolytica cysteine protease, putative 0.0294 0.0382 0.3915
Echinococcus granulosus cpg binding protein 0.0044 0.0038 0.0093
Trichomonas vaginalis pyruvate kinase, putative 0.005 0.0047 0.0334
Schistosoma mansoni ap endonuclease 0.0027 0.0015 0.0033
Loa Loa (eye worm) hypothetical protein 0.0052 0.005 0.0123
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0047 0.0043 0.0102
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0005 0.0004
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0115 0.0137 0.0936
Toxoplasma gondii cathepsin CPC1 0.0243 0.0313 0.2189
Trypanosoma cruzi cysteine peptidase, putative 0.0907 0.1224 0.3145
Schistosoma mansoni histone deacetylase 4 5 0.0044 0.004 0.0096
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0033 0.0023 0.0056
Schistosoma mansoni cathepsin B (C01 family) 0.0243 0.0313 0.0799
Giardia lamblia Hypothetical protein 0.0243 0.0313 0.2179
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0033 0.0023 0.0055
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0138 0.0168 0.0428
Brugia malayi Thioredoxin reductase 0.0079 0.0087 0.0219
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0027 0.0016 0.0012
Echinococcus multilocularis histone deacetylase 7 0.0044 0.004 0.0067
Giardia lamblia Alanyl dipeptidyl peptidase 0.0027 0.0016 0.0079
Loa Loa (eye worm) hypothetical protein 0.0721 0.097 0.2492
Onchocerca volvulus 0.0034 0.0026 0.0226
Brugia malayi topoisomerase 0.0052 0.005 0.0122
Leishmania major acetyl-CoA synthetase, putative 0.0037 0.003 0.0189
Loa Loa (eye worm) jmjC domain-containing protein 0.0051 0.0048 0.012
Loa Loa (eye worm) hypothetical protein 0.0243 0.0313 0.08
Loa Loa (eye worm) glutathione reductase 0.0079 0.0087 0.022
Echinococcus multilocularis sterol regulatory element binding protein 0.0131 0.0159 0.0279
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0027 0.0016 0.0034
Trypanosoma cruzi hypothetical protein, conserved 0.0052 0.005 0.0121
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0016 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.0243 0.0313 0.2204
Echinococcus granulosus sterol regulatory element binding protein 0.0131 0.0159 0.0404
Onchocerca volvulus 0.0243 0.0313 0.2965
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0037 0.003 0.0348
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0006
Loa Loa (eye worm) pyruvate kinase 0.005 0.0047 0.0117
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0027 0.0016 0.0168
Echinococcus granulosus calpain 5 0.0021 0.0007 0.0012
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0057 0.0057 0.037
Leishmania major hypothetical protein, conserved 0.0026 0.0014 0.0081
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0907 0.1224 0.8631
Trypanosoma brucei histone deacetylase, putative 0.0044 0.004 0.0248
Echinococcus granulosus GPCR family 2 0.0063 0.0064 0.016
Trypanosoma brucei oligopeptidase b 0.0027 0.0016 0.0079
Loa Loa (eye worm) hypothetical protein 0.008 0.0088 0.0221
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.0027 0.0016 0.0036
Brugia malayi hypothetical protein 0.0031 0.0021 0.0048
Trypanosoma cruzi pyruvate kinase 2, putative 0.005 0.0047 0.0115
Echinococcus granulosus lysine specific demethylase 5A 0.0051 0.0048 0.0119
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0032 0.0022 0.0157
Trichomonas vaginalis importin beta-1, putative 0.0051 0.0049 0.0345
Loa Loa (eye worm) hypothetical protein 0.0048 0.0045 0.0111
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0243 0.0313 0.2204
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0005 0.0006
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0243 0.0313 0.3224
Brugia malayi Importin beta-1 subunit 0.0063 0.0065 0.0163
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0007 0.0015
Trichomonas vaginalis D-aminoacylase, putative 0.0026 0.0014 0.0101
Brugia malayi Papain family cysteine protease containing protein 0.0294 0.0382 0.0979
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0011 0.0074
Echinococcus multilocularis cpg binding protein 0.0044 0.0038 0.0064
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0001
Mycobacterium ulcerans aminopeptidase N PepN 0.0034 0.0026 0.029
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0418 0.0554 0.3884
Giardia lamblia Cathepsin L-like protease 0.0243 0.0313 0.2179
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0027 0.0016 0.0036
Echinococcus multilocularis GPCR, family 2 0.0063 0.0064 0.0111
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.005 0.0351
Brugia malayi F/Y-rich N-terminus family protein 0.0026 0.0014 0.003
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0022 0.0009 0.0016
Echinococcus granulosus histone acetyltransferase KAT2B 0.0105 0.0123 0.0311
Plasmodium falciparum cysteine repeat modular protein 1 0.0018 0.0003 0.003
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0016 0.0034
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0243 0.0313 0.2179
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0006
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0023 0.0055
Trypanosoma cruzi hypothetical protein, conserved 0.0052 0.005 0.0121
Mycobacterium tuberculosis Probable peptidase 0.0027 0.0016 0.0011
Loa Loa (eye worm) hypothetical protein 0.0127 0.0153 0.0388
Trichomonas vaginalis ap endonuclease, putative 0.0027 0.0015 0.0107
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0027 0.0015 0.0075
Mycobacterium ulcerans hypothetical protein 0.022 0.0281 0.3852
Entamoeba histolytica cysteine protease, putative 0.0243 0.0313 0.3191
Echinococcus multilocularis aminopeptidase N 0.0034 0.0026 0.0041
Trypanosoma brucei importin beta-1 subunit, putative 0.0063 0.0065 0.043
Mycobacterium ulcerans aldehyde dehydrogenase 0.0139 0.017 0.2302
Schistosoma mansoni histone deacetylase hda2 0.0044 0.004 0.0096
Brugia malayi Patched family protein 0.0019 0.0004 0.0005
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0007 0.0028
Brugia malayi Papain family cysteine protease containing protein 0.0243 0.0313 0.0799
Echinococcus multilocularis acylamino acid releasing enzyme 0.0027 0.0016 0.0024
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0006
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0063 0.0064 0.016
Trichomonas vaginalis glucosylceramidase, putative 0.0195 0.0247 0.174
Trypanosoma brucei importin beta-1 subunit, putative 0.0063 0.0065 0.043
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0201 0.0255 0.025
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0047 0.0043 0.0268
Giardia lamblia Cysteine protease 0.0243 0.0313 0.2179
Schistosoma mansoni hypothetical protein 0.0127 0.0153 0.0387
Loa Loa (eye worm) hypothetical protein 0.0037 0.003 0.0072
Loa Loa (eye worm) hypothetical protein 0.0051 0.0048 0.012
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.002 0.0006 0.001
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0721 0.097 0.2492
Onchocerca volvulus 0.0026 0.0014 0.0119
Schistosoma mansoni calpain (C02 family) 0.0021 0.0007 0.0012
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0243 0.0313 0.0799
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0006
Schistosoma mansoni tar DNA-binding protein 0.01 0.0116 0.0293
Plasmodium falciparum histone acetyltransferase GCN5 0.0029 0.0019 0.0192
Schistosoma mansoni steroid hormone receptor ad4bp 0.0033 0.0023 0.0055
Treponema pallidum DNA ligase (lig) 0.0052 0.005 0.0488
Echinococcus granulosus inhibitor of apoptosis protein 0.0041 0.0034 0.0082
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0016 0.0112
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1047 0.1418 0.3645
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0721 0.097 0.684
Leishmania major cathepsin L-like protease 0.0907 0.1224 0.8632
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0027 0.0016 0.0095
Toxoplasma gondii LsmAD domain-containing protein 0.0075 0.0081 0.0554
Toxoplasma gondii NADPH-glutathione reductase 0.0027 0.0016 0.0095
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0027 0.0016 0.0092
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0127 0.0153 0.0148
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0001
Echinococcus multilocularis calpain A 0.0057 0.0057 0.0097
Loa Loa (eye worm) hypothetical protein 0.0081 0.009 0.0227
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0005 0.0007
Toxoplasma gondii preprocathepsin c precursor, putative 0.0243 0.0313 0.2189
Loa Loa (eye worm) patched family protein 0.0019 0.0004 0.0006
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0201 0.0255 0.069
Schistosoma mansoni cpg binding protein 0.0044 0.0038 0.0093
Entamoeba histolytica prolyl oligopeptidase family protein 0.0027 0.0016 0.0116
Schistosoma mansoni jumonji domain containing protein 0.0104 0.0122 0.0307
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0721 0.097 0.684
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0027 0.0016 0.0092
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0243 0.0313 0.3224
Trichomonas vaginalis glucosylceramidase, putative 0.0128 0.0155 0.1089
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0007 0.0028
Echinococcus granulosus microtubule associated protein 2 0.2309 0.3151 0.8108
Brugia malayi Patched family protein 0.0019 0.0004 0.0005
Plasmodium falciparum histone deacetylase 2 0.0044 0.004 0.041
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0166 0.0207 0.0202
Onchocerca volvulus Cathepsin F homolog 0.0721 0.097 0.9236
Echinococcus granulosus histone deacetylase 6 0.0044 0.004 0.0096
Trypanosoma cruzi DNA repair protein, putative 0.0097 0.0112 0.0281
Trichomonas vaginalis chromobox protein, putative 0.0039 0.0032 0.0223
Giardia lamblia Histone acetyltransferase GCN5 0.0029 0.0019 0.0099
Plasmodium vivax vivapain-2 0.0721 0.097 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0034 0.0082
Mycobacterium ulcerans esterase/lipase LipP 0.0026 0.0014 0.0135
Entamoeba histolytica acyl-CoA synthetase, putative 0.0127 0.0153 0.1534
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0051 0.0048 0.012
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0027 0.0016 0.0082
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0139 0.017 0.0432
Echinococcus granulosus pyruvate kinase 0.005 0.0047 0.0116
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0037 0.003 0.0025
Trypanosoma cruzi histone deacetylase, putative 0.0044 0.004 0.0095
Loa Loa (eye worm) hypothetical protein 0.0052 0.005 0.0123
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0033 0.0023 0.0038
Echinococcus multilocularis cathepsin L 0.0294 0.0382 0.0677
Plasmodium falciparum thioredoxin reductase 0.0027 0.0016 0.0168
Entamoeba histolytica cysteine protease, putative 0.0294 0.0382 0.3915
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0721 0.097 0.684
Echinococcus multilocularis cathepsin b 0.2844 0.3886 0.6912
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0006
Brugia malayi Patched family protein 0.0019 0.0004 0.0005
Brugia malayi cytoplasmic intermediate filament protein 0.0043 0.0038 0.0093
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0016 0.0033
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0007 0.0028
Trypanosoma cruzi cysteine peptidase, putative 0.0907 0.1224 0.3145
Mycobacterium ulcerans acetyl-CoA synthetase 0.0037 0.003 0.0348
Mycobacterium ulcerans acyl-CoA synthetase 0.0127 0.0153 0.206
Brugia malayi beta-lactamase family protein 0.0026 0.0014 0.0031
Plasmodium falciparum ataxin-2 like protein, putative 0.0075 0.0081 0.0839
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0243 0.0313 0.2204
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0721 0.097 1
Entamoeba histolytica prolyl oligopeptidase family protein 0.0027 0.0016 0.0116
Entamoeba histolytica cysteine proteinase, putative 0.0294 0.0382 0.3915
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0034 0.0026 0.0041
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0721 0.097 0.684
Echinococcus granulosus nibrin 0.0052 0.005 0.0122
Chlamydia trachomatis pyruvate kinase 0.005 0.0047 0.044
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0007 0.001
Echinococcus granulosus intermediate filament protein 0.0081 0.009 0.0226
Plasmodium vivax vivapain-2 0.0721 0.097 1
Echinococcus multilocularis microtubule associated protein 2 0.2309 0.3151 0.5604
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0034 0.0026 0.006
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0007 0.001
Schistosoma mansoni hypothetical protein 0.0255 0.033 0.0843
Brugia malayi Histone deacetylase family protein 0.0044 0.004 0.0096
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.067 0.09 0.6347
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.005 0.0047 0.008
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0006
Echinococcus granulosus cathepsin b 0.2844 0.3886 1
Brugia malayi TAR-binding protein 0.01 0.0116 0.0293
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0087 0.0099 0.0248
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0181 0.0227 0.0222
Trypanosoma cruzi major cysteine proteinase, putative 0.0243 0.0313 0.0797
Loa Loa (eye worm) hypothetical protein 0.0038 0.003 0.0073
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0037 0.003 0.0306
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0037 0.003 0.0025
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0006
Giardia lamblia Cathepsin B precursor 0.0243 0.0313 0.2179
Brugia malayi Patched family protein 0.0019 0.0004 0.0005
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0027 0.0016 0.0004
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0721 0.097 0.684
Plasmodium vivax acyl-CoA synthetase, putative 0.0095 0.0109 0.1121
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.009 0.0102 0.0097
Mycobacterium leprae Probable pyruvate kinase PykA 0.005 0.0047 0.0095
Leishmania major cathepsin L-like protease 0.0721 0.097 0.6833
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0005 0.0032
Echinococcus granulosus geminin 0.0565 0.0756 0.194
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0057 0.0057 0.0381
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0027 0.0015 0.0032
Onchocerca volvulus Pyruvate kinase homolog 0.005 0.0047 0.0434
Plasmodium vivax acetyl-CoA synthetase, putative 0.0037 0.003 0.0306
Echinococcus granulosus tar DNA binding protein 0.01 0.0116 0.0293
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0095 0.0109 0.1448
Entamoeba histolytica hypothetical protein, conserved 0.0027 0.0016 0.0116
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0907 0.1224 0.8631
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0022 0.0157
Loa Loa (eye worm) ctsf protein 0.0721 0.097 0.2492
Brugia malayi Cathepsin L-like precursor 0.0721 0.097 0.2491
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0127 0.0153 0.206
Loa Loa (eye worm) TAR-binding protein 0.01 0.0116 0.0294
Brugia malayi Cathepsin L-like precursor 0.0051 0.0048 0.0119
Onchocerca volvulus 0.078 0.105 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.0073 0.0183
Trichomonas vaginalis antibiotic synthetase, putative 0.0037 0.003 0.0209
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0041 0.0034 0.0082
Echinococcus multilocularis calpain 0.0021 0.0007 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0033 0.0023 0.0055
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0343 0.045 0.0796
Trypanosoma cruzi pyruvate kinase 2, putative 0.005 0.0047 0.0115
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0198 0.025 0.0638
Schistosoma mansoni cpg binding protein 0.0041 0.0035 0.0085
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0005 0.0006
Mycobacterium ulcerans acyl-CoA synthetase 0.0127 0.0153 0.206
Loa Loa (eye worm) hypothetical protein 0.0033 0.0023 0.0056
Echinococcus granulosus importin subunit beta 1 0.0063 0.0065 0.0163
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0008 0.0058
Trichomonas vaginalis D-aminoacylase, putative 0.0026 0.0014 0.0101
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0047 0.0043 0.0439
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0033 0.0023 0.0055
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0907 0.1224 0.8631
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0081 0.009 0.0227
Loa Loa (eye worm) hypothetical protein 0.0022 0.0009 0.0018
Toxoplasma gondii pyruvate kinase PyKII 0.0026 0.0014 0.0078
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0051 0.0049 0.0345
Mycobacterium ulcerans hypothetical protein 0.0026 0.0014 0.0135
Toxoplasma gondii patched family protein 0.0019 0.0004 0.0008
Schistosoma mansoni cathepsin F (C01 family) 0.0721 0.097 0.2491
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0051 0.0048 0.0119
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0034 0.0026 0.006
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0033 0.0023 0.0055
Echinococcus granulosus Protein patched homolog 1 0.0131 0.0159 0.0404
Entamoeba histolytica cysteine protease, putative 0.0243 0.0313 0.3191
Onchocerca volvulus 0.0721 0.097 0.9236
Trypanosoma cruzi PAB1-binding protein , putative 0.0075 0.0081 0.0202
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0243 0.0313 0.3224
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0198 0.0251 0.1751
Brugia malayi Patched related family protein 12 0.0019 0.0004 0.0005
Echinococcus granulosus cathepsin l cysteine peptidase 0.0721 0.097 0.2491
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0027 0.0016 0.0034
Onchocerca volvulus 0.0037 0.003 0.0265
Toxoplasma gondii patched family protein 0.0019 0.0004 0.0008
Leishmania major oligopeptidase b 0.0027 0.0016 0.0092
Schistosoma mansoni aldehyde dehydrogenase 0.0139 0.017 0.0432
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0037 0.003 0.0072
Brugia malayi prolyl oligopeptidase family protein 0.0027 0.0016 0.0035
Echinococcus multilocularis protein patched 0.0131 0.0159 0.0279
Echinococcus granulosus lamin 0.0081 0.009 0.0226
Brugia malayi hypothetical protein 0.0088 0.01 0.0251
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0016 0.0164
Onchocerca volvulus 0.067 0.09 0.8569
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0027 0.0016 0.0168
Plasmodium vivax vivapain-3 0.0294 0.0382 0.3944
Echinococcus granulosus calpain 7 C02 family 0.0021 0.0007 0.0012
Loa Loa (eye worm) hypothetical protein 0.0119 0.0143 0.0363
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0006
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0027 0.0016 0.0156
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0243 0.0313 0.0799
Leishmania major DNA polymerase eta, putative 0.0019 0.0005 0.0012
Schistosoma mansoni histone deacetylase 4 5 0.0044 0.004 0.0096
Brugia malayi prolyl oligopeptidase family protein 0.0343 0.045 0.1152
Schistosoma mansoni hypothetical protein 0.0675 0.0906 0.2327
Echinococcus multilocularis lysine specific demethylase 5A 0.0048 0.0045 0.0076
Plasmodium falciparum glutathione reductase 0.0027 0.0016 0.0168
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0243 0.0313 0.3191
Loa Loa (eye worm) hypothetical protein 0.0033 0.0023 0.0056
Trypanosoma cruzi PAB1-binding protein , putative 0.0075 0.0081 0.0202
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0027 0.0016 0.0036
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0041 0.0034 0.0057
Schistosoma mansoni hypothetical protein 0.0127 0.0153 0.0387
Mycobacterium ulcerans acyl-CoA synthetase 0.0037 0.003 0.0348
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0006
Echinococcus granulosus peregrin 0.0043 0.0037 0.009
Brugia malayi calpain family protein 1 0.0055 0.0054 0.0132
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0057 0.0057 0.0141
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0026 0.0014 0.0031
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0026 0.0014 0.001
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0063 0.0064 0.016
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0027 0.0015 0.0147
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0119 0.0143 0.1344
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0021 0.0007 0.0015
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0014 0.0029
Trypanosoma cruzi Aminopeptidase M1, putative 0.0034 0.0026 0.0058
Echinococcus multilocularis geminin 0.0565 0.0756 0.1341
Schistosoma mansoni caspase-7 (C14 family) 0.0031 0.0021 0.0048
Trypanosoma cruzi oligopeptidase b 0.0027 0.0016 0.0033
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0542 0.0723 1
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0198 0.0251 0.1741
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0243 0.0313 0.3224
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0007 0.001
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0127 0.0153 0.0148
Trichomonas vaginalis glucosylceramidase, putative 0.0195 0.0247 0.174
Loa Loa (eye worm) steroid hormone receptor 0.0033 0.0023 0.0056
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0032 0.0022 0.0137
Schistosoma mansoni calpain C (C02 family) 0.0021 0.0007 0.0012
Plasmodium falciparum importin beta, putative 0.0063 0.0065 0.0675
Brugia malayi hypothetical protein 0.078 0.105 0.2697
Loa Loa (eye worm) hypothetical protein 0.0033 0.0023 0.0056
Brugia malayi Patched family protein 0.0019 0.0004 0.0005
Toxoplasma gondii cathepsin B 0.1047 0.1418 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0026 0.0014 0.001
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0027 0.0016 0.0036
Loa Loa (eye worm) hypothetical protein 0.0041 0.0034 0.0083
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0047 0.0043 0.028
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0721 0.097 0.1722
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0014 0.0029
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0034 0.0026 0.018
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0023 0.0055
Mycobacterium tuberculosis Probable lipase LipD 0.0026 0.0014 0.001
Onchocerca volvulus Cathepsin L homolog 0.0243 0.0313 0.2965
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0047 0.0043 0.0268
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0131 0.0159 0.0404
Brugia malayi acetyltransferase, GNAT family protein 0.0108 0.0127 0.0322
Trichomonas vaginalis glucosylceramidase, putative 0.0128 0.0155 0.1089
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0079 0.0087 0.0083
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0294 0.0382 0.0977
Echinococcus granulosus Dipeptidyl peptidase 9 0.0115 0.0137 0.0347
Schistosoma mansoni ran 0.0047 0.0043 0.0104
Schistosoma mansoni topbp1 0.0052 0.005 0.0122
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0033 0.0023 0.0055
Entamoeba histolytica cysteine protease, putative 0.0243 0.0313 0.3191
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0027 0.0015 0.0109
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.0026 0.0014 0.0032
Echinococcus multilocularis jumonji domain containing protein 0.0056 0.0055 0.0094
Loa Loa (eye worm) hypothetical protein 0.0031 0.0021 0.0049
Brugia malayi protein C24B5.3 0.0019 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0037 0.003 0.0072
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0037 0.003 0.0348
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0243 0.0313 0.0799
Brugia malayi MH2 domain containing protein 0.0117 0.014 0.0353
Giardia lamblia Cathepsin B precursor 0.0243 0.0313 0.2179
Echinococcus multilocularis pyruvate kinase 0.004 0.0033 0.0055
Echinococcus multilocularis musashi 0.0081 0.009 0.0156
Schistosoma mansoni DNA ligase IV 0.0052 0.005 0.0122
Chlamydia trachomatis DNA ligase 0.0052 0.005 0.0474
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0243 0.0313 0.2179
Echinococcus multilocularis histone deacetylase 6 0.0044 0.004 0.0067
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0032 0.0023 0.0018
Trichomonas vaginalis penicillin-binding protein, putative 0.0026 0.0014 0.0101
Mycobacterium ulcerans lipase LipD 0.0026 0.0014 0.0135
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0005 0.0004
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0047 0.0043 0.0105
Trichomonas vaginalis esterase, putative 0.0026 0.0014 0.0101
Plasmodium falciparum replication factor C subunit 1, putative 0.0052 0.005 0.0513
Loa Loa (eye worm) hypothetical protein 0.0031 0.0021 0.0049
Toxoplasma gondii ATPase, AAA family protein 0.0052 0.005 0.0331
Brugia malayi cathepsin B-like cysteine proteinase 0.2844 0.3886 1
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0047 0.0043 0.0439
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0198 0.025 0.0639
Plasmodium falciparum pyruvate kinase 2 0.0026 0.0014 0.0144
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0005 0.0004
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0027 0.0016 0.0095
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.003 0.0025
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0139 0.017 0.0165
Mycobacterium ulcerans beta-lactamase 0.0026 0.0014 0.0135
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0047 0.0043 0.0102
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0243 0.0313 0.2204
Loa Loa (eye worm) hypothetical protein 0.0095 0.0109 0.0275
Giardia lamblia Hypothetical protein 0.0243 0.0313 0.2179
Mycobacterium ulcerans acyl-CoA synthetase 0.0037 0.003 0.0348
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0037 0.003 0.0177
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0721 0.097 1
Schistosoma mansoni cathepsin s 0.0051 0.0048 0.0119
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0005 0.0004
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0027 0.0015 0.0033
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0033 0.0023 0.0055
Trichomonas vaginalis glucosylceramidase, putative 0.0128 0.0155 0.1089
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0022 0.0009 0.0017
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0027 0.0016 0.0011
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0026 0.0014 0.0032
Trichomonas vaginalis glucosylceramidase, putative 0.0195 0.0247 0.174
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0033 0.0023 0.0038
Echinococcus multilocularis cathepsin L 0.0243 0.0313 0.0552
Mycobacterium tuberculosis Probable dehydrogenase 0.0181 0.0227 0.0222
Schistosoma mansoni tar DNA-binding protein 0.01 0.0116 0.0293
Echinococcus multilocularis thyroid hormone receptor alpha 0.0033 0.0023 0.0038
Entamoeba histolytica cysteine proteinase, putative 0.0294 0.0382 0.3915
Echinococcus multilocularis cathepsin L cysteine protease 0.0721 0.097 0.1722
Brugia malayi exodeoxyribonuclease III family protein 0.0027 0.0015 0.0033
Plasmodium vivax vivapain-1 0.0294 0.0382 0.3944
Brugia malayi Patched family protein 0.0019 0.0004 0.0005
Plasmodium vivax unspecified product 0.0051 0.0048 0.05
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0033 0.0023 0.0055
Entamoeba histolytica hypothetical protein 0.0139 0.017 0.1711
Toxoplasma gondii propionate-CoA ligase 0.0037 0.003 0.0189
Loa Loa (eye worm) hypothetical protein 0.0051 0.0048 0.012
Schistosoma mansoni thyroid hormone receptor 0.0033 0.0023 0.0055
Brugia malayi PHD-finger family protein 0.004 0.0034 0.0081
Toxoplasma gondii prolyl endopeptidase 0.0027 0.0016 0.0092
Entamoeba histolytica cysteine protease, putative 0.0294 0.0382 0.3915
Leishmania major acetyl-CoA synthetase, putative 0.0037 0.003 0.0189
Onchocerca volvulus 0.0721 0.097 0.9236
Loa Loa (eye worm) hypothetical protein 0.0026 0.0014 0.0032
Brugia malayi Peptidase family M1 containing protein 0.0034 0.0026 0.006
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0037 0.003 0.0044
Mycobacterium ulcerans acyl-CoA synthetase 0.0037 0.003 0.0348
Echinococcus granulosus replication factor c subunit 1 0.0052 0.005 0.0122
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0907 0.1224 0.8631
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0032 0.0022 0.023
Schistosoma mansoni aldehyde dehydrogenase 0.0139 0.017 0.0432
Mycobacterium ulcerans acyl-CoA synthetase 0.0037 0.003 0.0348
Onchocerca volvulus Cathepsin L homolog 0.0721 0.097 0.9236
Entamoeba histolytica cysteine proteinase 2 0.0294 0.0382 0.3915
Giardia lamblia Encystation-specific protease 0.0243 0.0313 0.2179
Trypanosoma brucei histone deacetylase 4 0.0044 0.004 0.0248
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0007 0.001
Trypanosoma cruzi oligopeptidase b 0.0027 0.0016 0.0033
Loa Loa (eye worm) hypothetical protein 0.0027 0.0016 0.0036
Trichomonas vaginalis glucosylceramidase, putative 0.0128 0.0155 0.1089
Loa Loa (eye worm) prolyl oligopeptidase 0.0343 0.045 0.1152
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0721 0.097 0.684
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0037 0.003 0.0348
Plasmodium falciparum histone deacetylase, putative 0.0044 0.004 0.041
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0037 0.003 0.0025
Brugia malayi calpain family protein 1 0.0055 0.0054 0.0132
Schistosoma mansoni chromobox protein 0.0039 0.0032 0.0076
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0243 0.0313 0.2204
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0006
Giardia lamblia Cathepsin L precursor 0.0243 0.0313 0.2179
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0052 0.005 0.0122
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0721 0.097 0.684
Loa Loa (eye worm) hypothetical protein 0.0052 0.005 0.0123
Plasmodium falciparum cysteine proteinase falcipain 1 0.0294 0.0382 0.3944
Leishmania major cathepsin L-like protease 0.0721 0.097 0.6833
Loa Loa (eye worm) hypothetical protein 0.1252 0.1699 0.437
Schistosoma mansoni hypothetical protein 0.0127 0.0153 0.0387
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0907 0.1224 0.8631
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0052 0.005 0.0467
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0243 0.0313 0.0799
Echinococcus multilocularis cysteine protease 0.0721 0.097 0.1722
Echinococcus multilocularis dnaJ subfamily B 0.0296 0.0385 0.0681
Plasmodium falciparum pyruvate kinase 0.005 0.0047 0.0489
Brugia malayi jmjC domain containing protein 0.0051 0.0048 0.0119
Brugia malayi Heterochromatin protein 1 0.0039 0.0032 0.0076
Plasmodium vivax hypothetical protein, conserved 0.0026 0.0014 0.0148
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0027 0.0016 0.0168
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2844 0.3886 1
Echinococcus granulosus lamin dm0 0.0081 0.009 0.0226
Trypanosoma brucei PAB1-binding protein , putative 0.0075 0.0081 0.0543
Brugia malayi Patched family protein 0.0019 0.0004 0.0005
Schistosoma mansoni patched 1 0.0131 0.0159 0.0404
Plasmodium vivax calpain, putative 0.0021 0.0007 0.0071
Entamoeba histolytica cysteine protease, putative 0.0294 0.0382 0.3915
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0052 0.005 0.0628
Loa Loa (eye worm) hypothetical protein 0.0026 0.0014 0.0032
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0027 0.0016 0.0162
Echinococcus multilocularis tissue type plasminogen activator 0.0018 0.0003 0.0001
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0026 0.0014 0.0031
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0037 0.003 0.0069
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0027 0.0016 0.0035
Onchocerca volvulus 0.0026 0.0014 0.0119
Onchocerca volvulus Deterin homolog 0.0041 0.0034 0.0309
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0115 0.0137 0.0345
Schistosoma mansoni acetyl-CoA synthetase 0.0037 0.003 0.0071
Plasmodium falciparum serine repeat antigen 5 0.0243 0.0313 0.3224
Loa Loa (eye worm) hypothetical protein 0.0095 0.0109 0.0275
Brugia malayi Patched family protein 0.0019 0.0004 0.0005
Onchocerca volvulus Pyruvate kinase homolog 0.005 0.0047 0.0434
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0907 0.1224 0.8631
Brugia malayi Patched related family protein 10 0.0019 0.0004 0.0005
Onchocerca volvulus 0.0081 0.009 0.084
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0026 0.0014 0.0031
Schistosoma mansoni Replicative DNA helicase 0.0542 0.0723 0.1856
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0008 0.0058
Entamoeba histolytica cysteine protease, putative 0.0243 0.0313 0.3191
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0007 0.001
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0027 0.0016 0.0116
Loa Loa (eye worm) hypothetical protein 0.0034 0.0025 0.006
Brugia malayi Muscleblind-like protein 0.0113 0.0134 0.034
Echinococcus multilocularis cathepsin L cysteine protease 0.0721 0.097 0.1722
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.0007
Brugia malayi Cell death protein 3 precursor 0.0031 0.0021 0.0048
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0007 0.001
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0181 0.0227 0.0222
Plasmodium falciparum acyl-CoA synthetase 0.0095 0.0109 0.1121
Giardia lamblia Cathepsin L precursor 0.0243 0.0313 0.2179
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0037 0.003 0.0071
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0033 0.0023 0.0056
Plasmodium falciparum serine repeat antigen 6 0.0243 0.0313 0.3224
Echinococcus multilocularis chromobox protein 1 0.0039 0.0032 0.0052
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0311 0.0406 0.1038
Mycobacterium tuberculosis Probable reductase 0.0181 0.0227 0.0222
Loa Loa (eye worm) intermediate filament protein 0.0081 0.009 0.0227
Loa Loa (eye worm) hypothetical protein 0.0035 0.0027 0.0064
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0127 0.0153 0.206
Entamoeba histolytica pyruvate kinase, putative 0.0035 0.0027 0.0227
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0343 0.045 0.1152
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0006
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0016 0.0034
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0243 0.0313 0.3224
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0198 0.0251 0.0638
Entamoeba histolytica cysteine protease, putative 0.0243 0.0313 0.3191
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0006
Echinococcus granulosus cathepsin l1 0.0721 0.097 0.2491
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0059 0.0059 0.0145
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0057 0.0057 0.0097
Plasmodium vivax glutathione reductase, putative 0.0079 0.0087 0.0902
Leishmania major 4-coumarate:coa ligase-like protein 0.0127 0.0153 0.1059
Trypanosoma cruzi FHA domain containing protein, putative 0.0052 0.005 0.0121
Giardia lamblia Cathepsin B precursor 0.1047 0.1418 1
Brugia malayi latrophilin 2 splice variant baaae 0.0135 0.0164 0.0417
Plasmodium falciparum thioredoxin reductase 0.0079 0.0087 0.0902
Plasmodium vivax pyruvate kinase, putative 0.005 0.0047 0.0489
Giardia lamblia NADH oxidase lateral transfer candidate 0.0027 0.0016 0.0082
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0016 0.0033
Schistosoma mansoni tar DNA-binding protein 0.01 0.0116 0.0293
Brugia malayi Cathepsin L-like precursor 0.0721 0.097 0.2491
Trichomonas vaginalis ap endonuclease, putative 0.0027 0.0015 0.0107
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0026 0.0014 0.001
Echinococcus granulosus expressed conserved protein 0.0287 0.0374 0.0956
Loa Loa (eye worm) hypothetical protein 0.0243 0.0313 0.08
Plasmodium falciparum serine repeat antigen 3 0.0243 0.0313 0.3224
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0059 0.0059 0.0387
Trypanosoma cruzi major cysteine proteinase, putative 0.0428 0.0567 0.1453
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0023 0.0055
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0052 0.005 0.0331
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2844 0.3886 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.0168 0.0428
Entamoeba histolytica hypothetical protein 0.0052 0.005 0.0467
Loa Loa (eye worm) hypothetical protein 0.0041 0.0034 0.0083
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0037 0.003 0.0189
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0007 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0243 0.0313 0.2204
Loa Loa (eye worm) hypothetical protein 0.0135 0.0164 0.0418
Entamoeba histolytica cysteine protease, putative 0.0294 0.0382 0.3915
Onchocerca volvulus 0.0721 0.097 0.9236
Entamoeba histolytica hypothetical protein 0.0051 0.0049 0.046
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0675 0.0906 0.2328
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0243 0.0313 0.3224
Brugia malayi steroid hormone receptor 0.0033 0.0023 0.0055
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0051 0.0049 0.0345
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0721 0.097 0.684
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0033 0.0023 0.0055
Loa Loa (eye worm) calpain family protein 1 0.004 0.0034 0.0082
Brugia malayi prolyl oligopeptidase family protein 0.0115 0.0137 0.0347
Mycobacterium leprae Conserved hypothetical protein 0.2562 0.3499 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0907 0.1224 0.8631
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0721 0.097 0.684
Leishmania major mitochondrial DNA polymerase beta 0.0418 0.0554 0.3892
Onchocerca volvulus Protein patched homolog 0.0019 0.0004 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0023 0.0055
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0294 0.0382 0.2674
Leishmania major pyruvate kinase 0.005 0.0047 0.0314
Echinococcus multilocularis FTZ F1 alpha 0.0033 0.0023 0.0038
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0007 0.0015
Loa Loa (eye worm) hypothetical protein 0.0038 0.003 0.0073
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0243 0.0313 0.3224
Leishmania major cathepsin L-like protease 0.0907 0.1224 0.8632
Toxoplasma gondii cathepsin CPL 0.0721 0.097 0.6833
Echinococcus multilocularis replication factor c subunit 1 0.0052 0.005 0.0085
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0721 0.097 0.684
Trypanosoma cruzi cysteine peptidase, putative 0.0721 0.097 0.249
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0027 0.0016 0.0095
Trichomonas vaginalis D-aminoacylase, putative 0.0026 0.0014 0.0101
Echinococcus multilocularis histone deacetylase 0.0044 0.004 0.0067
Entamoeba histolytica hypothetical protein 0.0139 0.017 0.1711
Loa Loa (eye worm) thioredoxin reductase 0.0079 0.0087 0.022
Mycobacterium ulcerans acyl-CoA synthetase 0.0037 0.003 0.0348
Mycobacterium tuberculosis Conserved hypothetical protein 0.022 0.0281 0.0277
Brugia malayi Patched family protein 0.0019 0.0004 0.0005
Giardia lamblia Cathepsin L precursor 0.0243 0.0313 0.2179
Brugia malayi Cathepsin L-like precursor 0.0721 0.097 0.2491
Leishmania major histone deacetylase, putative 0.0044 0.004 0.026
Echinococcus multilocularis lamin 0.0081 0.009 0.0156
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0201 0.0255 0.025
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0243 0.0313 0.0799
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0033 0.0023 0.0055
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0243 0.0313 0.0799
Giardia lamblia Cathepsin B precursor 0.1047 0.1418 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0006
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0027 0.0016 0.0095
Echinococcus multilocularis beta LACTamase domain containing family member 0.0026 0.0014 0.0021
Brugia malayi hypothetical protein 0.0034 0.0026 0.006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0294 0.0382 0.2674
Onchocerca volvulus 0.0042 0.0036 0.0323
Schistosoma mansoni hypothetical protein 0.0034 0.0025 0.0058
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0027 0.0016 0.0162
Plasmodium vivax replication factor C subunit 1, putative 0.0052 0.005 0.0513
Loa Loa (eye worm) hypothetical protein 0.067 0.09 0.2312
Echinococcus granulosus prolyl endopeptidase 0.0027 0.0016 0.0035
Brugia malayi hypothetical protein 0.0019 0.0004 0.0005
Loa Loa (eye worm) RNA binding protein 0.01 0.0116 0.0294
Loa Loa (eye worm) hypothetical protein 0.0063 0.0064 0.0161
Schistosoma mansoni jumonji/arid domain-containing protein 0.0051 0.0048 0.0119
Brugia malayi cathepsin F-like cysteine proteinase 0.0243 0.0313 0.0799
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0021 0.0007 0.001
Mycobacterium ulcerans aldehyde dehydrogenase 0.0139 0.017 0.2302
Echinococcus granulosus cathepsin l1 0.067 0.09 0.2311
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.005 0.0047 0.0117
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0243 0.0313 0.3224
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0005 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0243 0.0313 0.2204
Schistosoma mansoni importin beta-1 0.0063 0.0065 0.0163
Trypanosoma brucei Aminopeptidase M1, putative 0.0034 0.0026 0.0148
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0001
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0037 0.003 0.0348
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0294 0.0382 0.2697
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0027 0.0016 0.0112
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.7067 0.9689 0.9689
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0037 0.003 0.0259
Brugia malayi cathepsin F-like cysteine proteinase 0.0051 0.0048 0.0119
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0037 0.003 0.0069
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0052 0.005 0.0102
Echinococcus multilocularis calpain 7 (C02 family) 0.0021 0.0007 0.0008
Echinococcus multilocularis inhibitor of apoptosis protein 0.0041 0.0034 0.0057
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0007 0.001
Echinococcus granulosus aminopeptidase N 0.0034 0.0026 0.006
Brugia malayi hypothetical protein 0.0019 0.0004 0.0005
Schistosoma mansoni hypothetical protein 0.0135 0.0164 0.0417
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0195 0.0247 0.0629
Loa Loa (eye worm) hypothetical protein 0.0243 0.0313 0.08
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.003 0.0025
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0005 0.0012
Echinococcus granulosus pyruvate kinase 0.0026 0.0014 0.003
Giardia lamblia Alanyl dipeptidyl peptidase 0.0027 0.0016 0.0079
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0243 0.0313 0.08
Onchocerca volvulus 0.0041 0.0034 0.0309
Loa Loa (eye worm) hypothetical protein 0.0044 0.004 0.0097
Loa Loa (eye worm) hypothetical protein 0.0075 0.0081 0.0205
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0907 0.1224 0.8631
Loa Loa (eye worm) fibroinase 0.0721 0.097 0.2492
Brugia malayi AMP-binding enzyme family protein 0.0127 0.0153 0.0387
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0721 0.097 0.684
Brugia malayi Papain family cysteine protease containing protein 0.0243 0.0313 0.0799
Onchocerca volvulus Cathepsin L homolog 0.0721 0.097 0.9236
Echinococcus granulosus snurportin 1 0.0675 0.0906 0.2327
Mycobacterium ulcerans acyl-CoA synthetase 0.0127 0.0153 0.206
Onchocerca volvulus Pyruvate kinase homolog 0.005 0.0047 0.0434
Trypanosoma brucei prolyl endopeptidase 0.0027 0.0016 0.0079
Schistosoma mansoni cathepsin F (C01 family) 0.067 0.09 0.2311
Echinococcus granulosus dna polymerase eta 0.0019 0.0005 0.0006
Brugia malayi N-terminal motif family protein 0.0119 0.0143 0.0362
Mycobacterium tuberculosis Probable esterase LipL 0.0026 0.0014 0.001
Loa Loa (eye worm) hypothetical protein 0.004 0.0034 0.0081
Schistosoma mansoni pyruvate kinase 0.005 0.0047 0.0116
Echinococcus multilocularis calpain 5 0.0021 0.0007 0.0008
Giardia lamblia Pyruvate kinase 0.0026 0.0014 0.0065
Onchocerca volvulus 0.0034 0.0026 0.0226
Trichomonas vaginalis glucosylceramidase, putative 0.0128 0.0155 0.1089
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0294 0.0382 0.0979
Plasmodium vivax serine-repeat antigen (SERA) 0.0243 0.0313 0.3224
Echinococcus multilocularis muscleblind protein 0.0113 0.0134 0.0235
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0181 0.0227 0.0222
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.0168 0.0428
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0418 0.0554 0.1418
Brugia malayi Kringle domain containing protein 0.0018 0.0003 0.0002
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0037 0.003 0.0025
Schistosoma mansoni lamin 0.0081 0.009 0.0226
Schistosoma mansoni nuclear hormone receptor 0.0033 0.0023 0.0055
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.0542 0.0723 0.2034
Trypanosoma brucei antigen, putative 0.0021 0.0007 0.0015
Loa Loa (eye worm) hypothetical protein 0.0127 0.0153 0.0388
Trichomonas vaginalis glucosylceramidase, putative 0.0195 0.0247 0.174
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0027 0.0016 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0023 0.0055
Echinococcus granulosus histone acetyltransferase KAT2B 0.0032 0.0022 0.0051
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0052 0.005 0.0351
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0243 0.0313 0.3224
Giardia lamblia Cysteine protease 0.0243 0.0313 0.2179
Brugia malayi protein C24B5.3 0.0019 0.0004 0.0005
Plasmodium vivax serine-repeat antigen (SERA) 0.0243 0.0313 0.3224
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0034 0.0026 0.016
Schistosoma mansoni topbp1 0.0052 0.005 0.0122
Loa Loa (eye worm) histone deacetylase 7A 0.0044 0.004 0.0097
Trypanosoma brucei pyruvate kinase 1 0.005 0.0047 0.0303
Loa Loa (eye worm) hypothetical protein 0.0026 0.0014 0.0032
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0005 0.0032
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0037 0.003 0.0025
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0037 0.003 0.0044
Brugia malayi nuclear hormone receptor 0.0033 0.0023 0.0055
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0037 0.003 0.0071
Echinococcus granulosus calpain 0.0021 0.0007 0.0012
Loa Loa (eye worm) oxidoreductase 0.0037 0.003 0.0072
Trichomonas vaginalis mercuric reductase, putative 0.0027 0.0016 0.0115
Chlamydia trachomatis replicative DNA helicase 0.0542 0.0723 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0043 0.0038 0.0094
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0059 0.0059 0.0145
Echinococcus multilocularis pyruvate kinase 0.0026 0.0014 0.0021
Loa Loa (eye worm) jmjC domain-containing protein 0.0083 0.0092 0.0232
Leishmania major pyruvate kinase 0.005 0.0047 0.0314
Onchocerca volvulus 0.0037 0.003 0.0265
Leishmania major 4-coumarate:coa ligase-like protein 0.0127 0.0153 0.1059
Onchocerca volvulus 0.0033 0.0023 0.0206
Trypanosoma cruzi DNA repair protein, putative 0.0097 0.0112 0.0281
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.01 0.0116 0.0294
Loa Loa (eye worm) hypothetical protein 0.0039 0.0032 0.0078
Echinococcus multilocularis nibrin 0.0052 0.005 0.0085
Brugia malayi AMP-binding enzyme family protein 0.0037 0.003 0.0071
Mycobacterium tuberculosis Probable oxidoreductase 0.0201 0.0255 0.025
Chlamydia trachomatis recombinase RecA 0.0316 0.0412 0.5603
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0243 0.0313 0.3224
Toxoplasma gondii histone lysine methyltransferase SET1 0.0081 0.0089 0.0611
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0115 0.0137 0.0947
Trypanosoma brucei histone deacetylase 3 0.0044 0.004 0.0248
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0006
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0034 0.0026 0.016
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0033 0.0023 0.0055
Echinococcus granulosus dna polymerase kappa 0.0019 0.0005 0.0006
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0052 0.005 0.0488
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0294 0.0382 0.0979
Schistosoma mansoni hypothetical protein 0.0063 0.0064 0.016
Trypanosoma brucei trypanothione reductase 0.0079 0.0087 0.0586
Onchocerca volvulus 0.0019 0.0004 0.0021
Loa Loa (eye worm) latrophilin receptor protein 2 0.0063 0.0064 0.0161
Brugia malayi hypothetical protein 0.1252 0.1699 0.4369
Echinococcus multilocularis lamin dm0 0.0081 0.009 0.0156
Echinococcus multilocularis hypothetical protein 0.0021 0.0007 0.0008
Loa Loa (eye worm) hypothetical protein 0.0243 0.0313 0.08
Onchocerca volvulus 0.0019 0.0004 0.0021
Brugia malayi Histone deacetylase family protein 0.0044 0.004 0.0096
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0115 0.0137 0.0345
Brugia malayi AMP-binding enzyme family protein 0.0037 0.003 0.0071
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0131 0.0159 0.0278
Brugia malayi AMP-binding enzyme family protein 0.0127 0.0153 0.0387
Plasmodium vivax thioredoxin reductase, putative 0.0079 0.0087 0.0902
Trichomonas vaginalis glucosylceramidase, putative 0.0195 0.0247 0.174
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0721 0.097 0.684
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0045 0.0041 0.0099
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0027 0.0016 0.0112
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0072 0.0077 0.0191
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0243 0.0313 0.2204
Toxoplasma gondii HEAT repeat-containing protein 0.0063 0.0065 0.0442
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0108 0.0127 0.0222
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0115 0.0137 0.0947
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0037 0.003 0.0069
Trypanosoma cruzi cysteine peptidase, putative 0.0051 0.0048 0.0117
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0243 0.0313 0.2179
Brugia malayi Steroid receptor seven-up type 2 0.0033 0.0023 0.0055
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0418 0.0554 0.1418
Trichomonas vaginalis pyruvate kinase, putative 0.005 0.0047 0.0334
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0063 0.0064 0.016
Schistosoma mansoni hypothetical protein 0.0063 0.0064 0.016
Brugia malayi RNA binding protein 0.01 0.0116 0.0293
Brugia malayi hypothetical protein 0.0019 0.0004 0.0005
Echinococcus granulosus muscleblind protein 0.0113 0.0134 0.034
Loa Loa (eye worm) hypothetical protein 0.0052 0.005 0.0123
Onchocerca volvulus 0.0721 0.097 0.9236
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.005 0.0351
Treponema pallidum replicative DNA helicase (dnaB) 0.0542 0.0723 1
Plasmodium vivax histone deacetylase 2, putative 0.0044 0.004 0.041
Trypanosoma cruzi cysteine proteinase, putative 0.0294 0.0382 0.0977
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0115 0.0137 0.0347
Plasmodium vivax histone deacetylase, putative 0.0044 0.004 0.041
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0721 0.097 0.684
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0005 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0243 0.0313 0.2204
Brugia malayi Intermediate filament tail domain containing protein 0.0081 0.009 0.0226
Loa Loa (eye worm) acetyltransferase 0.0108 0.0127 0.0323
Trypanosoma cruzi cysteine peptidase, putative 0.0907 0.1224 0.3145
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0721 0.097 0.684
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0139 0.017 0.0431
Loa Loa (eye worm) hypothetical protein 0.0033 0.0023 0.0056
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0041 0.0034 0.0082
Toxoplasma gondii ABC1 family protein 0.0026 0.0014 0.0081
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.0026 0.0014 0.0032
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0033 0.0023 0.0056
Giardia lamblia Cathepsin B precursor 0.0243 0.0313 0.2179
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.0014 0.0068
Loa Loa (eye worm) pyruvate kinase 0.005 0.0047 0.0117
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0131 0.0159 0.0403
Onchocerca volvulus Alhambra homolog 0.004 0.0034 0.0302
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0041 0.0034 0.0082
Toxoplasma gondii histone deacetylase HDAC1 0.0044 0.004 0.026
Plasmodium vivax hypothetical protein, conserved 0.004 0.0034 0.0346
Echinococcus multilocularis PHD finger protein rhinoceros 0.004 0.0034 0.0056
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.2844 0.3886 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0027 0.0015 0.0075
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0255 0.033 0.0843
Loa Loa (eye worm) hypothetical protein 0.0057 0.0057 0.0142
Entamoeba histolytica acetyltransferase, GNAT family 0.0029 0.0019 0.0145
Brugia malayi Papain family cysteine protease containing protein 0.0294 0.0382 0.0979
Loa Loa (eye worm) hypothetical protein 0.067 0.09 0.2312
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0033 0.0023 0.0056
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0127 0.0153 0.0397
Loa Loa (eye worm) calpain family protein 1 0.0055 0.0054 0.0133
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0052 0.005 0.0351
Schistosoma mansoni inhibitor of apoptosis protein 0.0041 0.0034 0.0082
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0037 0.003 0.0189
Entamoeba histolytica cysteine protease, putative 0.0294 0.0382 0.3915
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0721 0.097 0.684
Trypanosoma brucei prolyl oligopeptidase, putative 0.0027 0.0016 0.0079
Brugia malayi Patched family protein 0.0019 0.0004 0.0005
Leishmania major cysteine peptidase A (CPA) 0.0721 0.097 0.6833
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0721 0.097 0.684
Wolbachia endosymbiont of Brugia malayi recombinase A 0.0316 0.0412 0.561
Schistosoma mansoni calpain-7 (C02 family) 0.0026 0.0014 0.0031
Trypanosoma cruzi cruzipain precursor, putative 0.0907 0.1224 0.3145
Loa Loa (eye worm) hypothetical protein 0.0026 0.0014 0.0032
Trichomonas vaginalis glucosylceramidase, putative 0.0128 0.0155 0.1089
Echinococcus granulosus cathepsin b 0.2844 0.3886 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0095 0.0109 0.0104
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0138 0.0168 0.0429
Onchocerca volvulus 0.0019 0.0004 0.0021
Schistosoma mansoni DNA polymerase eta 0.0019 0.0005 0.0006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0907 0.1224 0.8631
Entamoeba histolytica cysteine protease, putative 0.0243 0.0313 0.3191
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0033 0.0023 0.0055
Trichomonas vaginalis antibiotic synthetase, putative 0.0037 0.003 0.0209
Toxoplasma gondii hypothetical protein 0.0019 0.0004 0.0008
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0005 0.0006
Brugia malayi hypothetical protein 0.0019 0.0004 0.0005
Entamoeba histolytica cysteine protease, putative 0.0294 0.0382 0.3915
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0007 0.0015
Echinococcus multilocularis Protein lozenge 0.0098 0.0113 0.0197
Leishmania major cathepsin L-like protease 0.0721 0.097 0.6833
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0542 0.0723 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0023 0.0011 0.0083
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0037 0.003 0.0025
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0037 0.003 0.0189
Schistosoma mansoni pyruvate kinase 0.0026 0.0014 0.003
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0057 0.0057 0.0141
Plasmodium vivax pyruvate kinase 2, putative 0.0026 0.0014 0.0144
Loa Loa (eye worm) patched family protein 0.0019 0.0004 0.0006
Entamoeba histolytica Ran family GTPase 0.0047 0.0043 0.0392
Mycobacterium tuberculosis Conserved protein 0.0026 0.0014 0.001
Trypanosoma cruzi importin beta-1 subunit, putative 0.0051 0.0049 0.0119
Brugia malayi Cathepsin L-like precursor 0.067 0.09 0.2311
Echinococcus multilocularis tar DNA binding protein 0.01 0.0116 0.0203
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.0022 0.0009 0.0018
Giardia lamblia Cathepsin L precursor 0.0243 0.0313 0.2179
Plasmodium falciparum serine repeat antigen 1 0.0243 0.0313 0.3224
Brugia malayi Cathepsin L-like precursor 0.0721 0.097 0.2491
Echinococcus granulosus acylamino acid releasing enzyme 0.0027 0.0016 0.0035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0243 0.0313 0.2204
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0052 0.005 0.0121
Entamoeba histolytica cysteine proteinase, putative 0.0721 0.097 1
Brugia malayi hypothetical protein 0.0052 0.005 0.0122
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0027 0.0016 0.0168
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0007 0.0015
Brugia malayi prolyl oligopeptidase family protein 0.0027 0.0016 0.0035
Loa Loa (eye worm) hypothetical protein 0.0095 0.0109 0.0275
Schistosoma mansoni ran 0.0047 0.0043 0.0104
Trypanosoma brucei Aminopeptidase M1, putative 0.0034 0.0026 0.0148
Loa Loa (eye worm) hypothetical protein 0.0033 0.0023 0.0056
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0721 0.097 0.684
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0023 0.0038
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0127 0.0153 0.0397
Schistosoma mansoni hypothetical protein 0.0127 0.0153 0.0387
Schistosoma mansoni retinoic acid receptor RXR 0.0033 0.0023 0.0055
Toxoplasma gondii thioredoxin reductase 0.0079 0.0087 0.0597
Leishmania major hypothetical protein, conserved 0.0075 0.0081 0.0554
Loa Loa (eye worm) hypothetical protein 0.0243 0.0313 0.08
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0006
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0023 0.0055
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0343 0.045 0.1152
Leishmania major trypanothione reductase 0.0079 0.0087 0.0597
Brugia malayi DKFZp564C0469 protein 0.0052 0.005 0.0122
Entamoeba histolytica cysteine proteinase, putative 0.0721 0.097 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0026 0.0014 0.0135
Echinococcus granulosus histone deacetylase 6 0.0044 0.004 0.0096
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0034 0.0025 0.0058
Entamoeba histolytica cysteine proteinase, putative 0.0294 0.0382 0.3915
Trichomonas vaginalis conserved hypothetical protein 0.0131 0.0159 0.1121
Trypanosoma cruzi cysteine proteinase, putative 0.0294 0.0382 0.0977
Giardia lamblia Cathepsin L precursor 0.0243 0.0313 0.2179
Schistosoma mansoni chromosome transmission fidelity factor 0.0052 0.005 0.0122
Echinococcus granulosus pyruvate kinase 0.0026 0.0014 0.003
Loa Loa (eye worm) patched family protein 0.0019 0.0004 0.0006
Schistosoma mansoni lamin 0.0081 0.009 0.0226
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0006
Trypanosoma cruzi trypanothione reductase, putative 0.0079 0.0087 0.0218
Leishmania major cathepsin L-like protease 0.0721 0.097 0.6833
Plasmodium falciparum lipid/sterol:H+ symporter 0.0019 0.0004 0.0042
Echinococcus granulosus cathepsin L 0.0243 0.0313 0.0799
Echinococcus multilocularis pyruvate kinase 0.0026 0.0014 0.0021
Loa Loa (eye worm) hypothetical protein 0.0033 0.0023 0.0056
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0027 0.0016 0.0079
Brugia malayi cathepsin L-like precursor 0.067 0.09 0.2311
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0055 0.0054 0.0132
Mycobacterium ulcerans recombinase A 0.0316 0.0412 0.5675
Echinococcus multilocularis importin subunit beta 1 0.0063 0.0065 0.0112
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0033 0.0023 0.0055
Trypanosoma cruzi prolyl endopeptidase 0.0027 0.0016 0.0033
Loa Loa (eye worm) aminopeptidase N 0.0034 0.0026 0.0061
Trypanosoma cruzi histone deacetylase, putative 0.0044 0.004 0.0095
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0243 0.0313 0.0799
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0005 0.0006
Trypanosoma brucei cysteine peptidase C (CPC) 0.1047 0.1418 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0095 0.0109 0.1307
Onchocerca volvulus 0.0255 0.033 0.3126
Schistosoma mansoni hypothetical protein 0.0296 0.0385 0.0986
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0243 0.0313 0.3191
Echinococcus granulosus cathepsin L 0.0294 0.0382 0.0979
Entamoeba histolytica hypothetical protein 0.0139 0.017 0.1711
Mycobacterium tuberculosis Probable lipase LipE 0.0026 0.0014 0.001
Entamoeba histolytica prolyl oligopeptidase family protein 0.0027 0.0016 0.0116
Giardia lamblia Pyruvate kinase 0.005 0.0047 0.0303
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0037 0.003 0.0348
Onchocerca volvulus Prolyl endopeptidase homolog 0.0027 0.0016 0.0134
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0033 0.0023 0.0038
Onchocerca volvulus Protein ultraspiracle homolog 0.0033 0.0023 0.0206
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0034 0.0026 0.0041
Schistosoma mansoni coup transcription factor 0.0033 0.0023 0.0055
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0243 0.0313 0.2204
Echinococcus multilocularis muscleblind protein 1 0.0113 0.0134 0.0235
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0034 0.0026 0.0041
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0027 0.0016 0.0035
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.002 0.0006 0.001
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0027 0.0016 0.0162
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0001
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0027 0.0015 0.0157
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0023 0.0055
Echinococcus granulosus cathepsin L cysteine protease 0.0294 0.0382 0.0979
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0721 0.097 0.684
Echinococcus granulosus tissue type plasminogen activator 0.0018 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0063 0.0065 0.0164
Loa Loa (eye worm) hypothetical protein 0.078 0.105 0.2698
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0033 0.0023 0.0206
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0033 0.0023 0.0055
Trypanosoma brucei pyruvate kinase 1, putative 0.005 0.0047 0.0303
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0034 0.0026 0.0041
Entamoeba histolytica cysteine protease, putative 0.0294 0.0382 0.3915
Schistosoma mansoni cathepsin S (C01 family) 0.0243 0.0313 0.0799
Echinococcus multilocularis apoptotic protease activating factor 1 0.0031 0.0021 0.0033
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0027 0.0016 0.0015
Brugia malayi Myosin head containing protein 0.0019 0.0004 0.0005
Toxoplasma gondii PHD-finger domain-containing protein 0.004 0.0034 0.0216
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0023 0.0055
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0027 0.0015 0.0157
Leishmania major histone deacetylase, putative 0.0044 0.004 0.026
Entamoeba histolytica cysteine protease, putative 0.0294 0.0382 0.3915
Loa Loa (eye worm) hypothetical protein 0.0198 0.025 0.0639
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0721 0.097 0.684
Plasmodium falciparum serine repeat antigen 7 0.0243 0.0313 0.3224
Entamoeba histolytica aminopeptidase, putative 0.0034 0.0026 0.0216
Onchocerca volvulus 0.0031 0.0021 0.0182
Echinococcus granulosus FTZ F1 alpha 0.0033 0.0023 0.0055
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.009 0.0102 0.0097
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0006
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0052 0.005 0.0351
Echinococcus multilocularis pyruvate kinase 0.0026 0.0014 0.0021
Brugia malayi cathepsin L-like cysteine proteinase 0.0243 0.0313 0.0799
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0127 0.0153 0.206
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0033 0.0023 0.0056
Plasmodium falciparum peptidase, putative 0.0027 0.0016 0.0164
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0037 0.003 0.0025
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.1047 0.1418 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0306 0.0399 0.0706
Brugia malayi ecdysteroid receptor 0.0033 0.0023 0.0055
Giardia lamblia Cathepsin L precursor 0.0243 0.0313 0.2179
Entamoeba histolytica cysteine protease, putative 0.0294 0.0382 0.3915
Loa Loa (eye worm) hypothetical protein 0.0027 0.0016 0.0036
Giardia lamblia Cysteine protease 0.0243 0.0313 0.2179
Brugia malayi Patched family protein 0.0019 0.0004 0.0005
Brugia malayi Patched related family protein 4 0.0019 0.0004 0.0005
Entamoeba histolytica cysteine protease, putative 0.0721 0.097 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0721 0.097 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0033 0.0023 0.0038
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0059 0.0059 0.0145
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0034 0.0026 0.0148
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0022 0.0009 0.0012
Brugia malayi jmjC domain containing protein 0.0131 0.0159 0.0403
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0037 0.003 0.0072
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0005 0.0004
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0027 0.0015 0.0087
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0115 0.0137 0.024
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0139 0.017 0.1181
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.067 0.09 0.2312
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0006
Trichomonas vaginalis glucosylceramidase, putative 0.0135 0.0164 0.1156
Schistosoma mansoni tar DNA-binding protein 0.01 0.0116 0.0293
Schistosoma mansoni Mername-AA248 (C02 family) 0.0021 0.0007 0.0012
Onchocerca volvulus Cell death protein 3 homolog 0.0031 0.0021 0.0182
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.003 0.0025
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0006
Schistosoma mansoni hypothetical protein 0.0139 0.017 0.0431
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0037 0.003 0.0071
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0041 0.0034 0.0082
Loa Loa (eye worm) prolyl oligopeptidase 0.0027 0.0016 0.0036
Brugia malayi Patched family protein 0.0019 0.0004 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0721 0.097 0.684
Schistosoma mansoni cathepsin F (C01 family) 0.0721 0.097 0.2491
Plasmodium vivax importin-beta 2, putative 0.0063 0.0065 0.0675
Schistosoma mansoni hypothetical protein 0.0041 0.0034 0.0082
Schistosoma mansoni hypothetical protein 0.004 0.0034 0.0081
Brugia malayi AMP-binding enzyme family protein 0.0037 0.003 0.0071
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.005 0.0351
Loa Loa (eye worm) hypothetical protein 0.0306 0.0399 0.1022
Echinococcus granulosus apoptotic protease activating factor 1 0.0031 0.0021 0.0048
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0006
Loa Loa (eye worm) heterochromatin protein 1 0.0039 0.0032 0.0077
Mycobacterium ulcerans pyruvate kinase 0.005 0.0047 0.0595
Echinococcus granulosus thioredoxin glutathione reductase 0.008 0.0088 0.0221
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.0168 0.0296
Mycobacterium ulcerans acyl-CoA synthetase 0.0037 0.003 0.0348
Entamoeba histolytica cysteine proteinase, putative 0.0294 0.0382 0.3915
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0721 0.097 0.684
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0039 0.0032 0.0053
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0005 0.0006
Echinococcus multilocularis protein dispatched 1 0.015 0.0185 0.0324
Schistosoma mansoni hypothetical protein 0.0063 0.0064 0.016
Trichomonas vaginalis replication factor C large subunit, putative 0.0052 0.005 0.0351
Echinococcus granulosus pyruvate kinase 0.005 0.0047 0.0116
Echinococcus multilocularis prolyl endopeptidase 0.0027 0.0016 0.0024
Trypanosoma cruzi trypanothione reductase, putative 0.0027 0.0016 0.0034
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0022 0.0008 0.0061
Loa Loa (eye worm) pyruvate kinase-PB 0.0035 0.0027 0.0064
Echinococcus multilocularis histone deacetylase 6 0.0044 0.004 0.0067
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.0052 0.005 0.0123
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0027 0.0016 0.0033
Echinococcus multilocularis chromobox protein 1 0.0039 0.0032 0.0052
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0139 0.017 0.0299
Giardia lamblia Cathepsin B precursor 0.0243 0.0313 0.2179
Entamoeba histolytica hypothetical protein 0.0139 0.017 0.1711
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.0168 0.0428
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0181 0.0227 0.0222
Toxoplasma gondii pyruvate kinase PyK1 0.005 0.0047 0.0314
Echinococcus granulosus GTP binding nuclear protein Ran 0.0047 0.0043 0.0104
Echinococcus granulosus cathepsin L cysteine proteinase 0.0721 0.097 0.2491
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0016 0.0034
Echinococcus multilocularis cathepsin b 0.2844 0.3886 0.6912
Echinococcus granulosus Niemann Pick C1 protein 0.0306 0.0399 0.1022
Schistosoma mansoni hypothetical protein 0.0031 0.0021 0.0048
Toxoplasma gondii patched family protein 0.0019 0.0004 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0023 0.0055
Brugia malayi hypothetical protein 0.0139 0.017 0.0431
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0027 0.0016 0.0082
Onchocerca volvulus 0.0034 0.0025 0.0223
Loa Loa (eye worm) patched family protein 0.0019 0.0004 0.0006
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0027 0.0015 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0033 0.0023 0.0055
Loa Loa (eye worm) histone deacetylase 0.0044 0.004 0.0097
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0721 0.097 0.1722
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0023 0.0038
Brugia malayi calpain 7 0.0021 0.0007 0.0012
Loa Loa (eye worm) beta-lactamase 0.0026 0.0014 0.0032
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0047 0.0043 0.0104
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0033 0.0023 0.0056
Schistosoma mansoni tar DNA-binding protein 0.01 0.0116 0.0293
Loa Loa (eye worm) PHD-finger family protein 0.004 0.0034 0.0081
Loa Loa (eye worm) hypothetical protein 0.0022 0.0009 0.0018
Brugia malayi Peptidase family M1 containing protein 0.0034 0.0026 0.006
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.009 0.0102 0.0097
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0006
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0032 0.0022 0.0137
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0294 0.0382 0.0979
Plasmodium vivax unspecified product 0.0294 0.0382 0.3944
Onchocerca volvulus 0.0018 0.0003 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0243 0.0313 0.2204
Leishmania major cathepsin L-like protease 0.0907 0.1224 0.8632
Brugia malayi Cathepsin L-like precursor 0.067 0.09 0.2311
Trichomonas vaginalis glucosylceramidase, putative 0.0135 0.0164 0.1156
Brugia malayi CHE-14 protein 0.0131 0.0159 0.0404
Brugia malayi Cathepsin L-like precursor 0.0721 0.097 0.2491
Echinococcus granulosus cysteine protease 0.0294 0.0382 0.0979
Loa Loa (eye worm) twinkle helicase 0.0155 0.0191 0.0488
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0721 0.097 0.684
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0721 0.097 0.684
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0139 0.017 0.0298
Loa Loa (eye worm) hypothetical protein 0.0095 0.0109 0.0275
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0034 0.0026 0.0041
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0243 0.0313 0.2204
Brugia malayi photoreceptor-specific nuclear receptor 0.0033 0.0023 0.0055
Brugia malayi Papain family cysteine protease containing protein 0.0243 0.0313 0.0799
Loa Loa (eye worm) hypothetical protein 0.0095 0.0109 0.0275
Entamoeba histolytica acyl-CoA synthetase, putative 0.0127 0.0153 0.1534
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.0168 0.0428
Toxoplasma gondii PHD-finger domain-containing protein 0.004 0.0034 0.0216
Loa Loa (eye worm) hypothetical protein 0.0055 0.0054 0.0133
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0006
Onchocerca volvulus 0.0026 0.0014 0.0119
Loa Loa (eye worm) hypothetical protein 0.0044 0.004 0.0097
Echinococcus multilocularis histone deacetylase 6 0.0044 0.004 0.0067
Loa Loa (eye worm) cathepsin B 0.1047 0.1418 0.3645
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0037 0.003 0.0177
Brugia malayi Papain family cysteine protease containing protein 0.0721 0.097 0.2491
Loa Loa (eye worm) hypothetical protein 0.005 0.0047 0.0117
Onchocerca volvulus 0.0019 0.0004 0.0021
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0027 0.0015 0.0011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0721 0.097 0.684
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0006
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0115 0.0137 0.0936
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0057 0.0057 0.0097
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0027 0.0016 0.0025
Mycobacterium ulcerans hypothetical protein 0.0127 0.0153 0.206
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0034 0.0026 0.006
Brugia malayi cathepsin Z-like cysteine proteinase 0.0243 0.0313 0.0799
Giardia lamblia PHD finger protein 15 0.004 0.0034 0.0204
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0052 0.005 0.0319
Loa Loa (eye worm) TK/ROR protein kinase 0.0018 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.078 0.105 0.2698
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0057 0.0057 0.0141
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.005 0.0047 0.0043
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0017 0.0002 0.0001
Brugia malayi chromobox protein homolog 3 0.0022 0.0008 0.0016
Echinococcus multilocularis Niemann Pick C1 protein 0.0437 0.0579 0.1027
Trypanosoma cruzi aminopeptidase, putative 0.0034 0.0026 0.0058
Echinococcus granulosus PHD finger protein rhinoceros 0.004 0.0034 0.0081
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0033 0.0023 0.0055
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0027 0.0015 0.0034
Echinococcus granulosus chromobox protein 1 0.0039 0.0032 0.0076
Echinococcus granulosus histone deacetylase 7 0.0044 0.004 0.0096
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.0168 0.0428
Brugia malayi Patched family protein 0.0019 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0033 0.0023 0.0056
Plasmodium falciparum serine repeat antigen 2 0.0243 0.0313 0.3224
Mycobacterium ulcerans acyl-CoA synthetase 0.0037 0.003 0.0348
Brugia malayi Pyruvate kinase, muscle isozyme 0.005 0.0047 0.0116
Giardia lamblia Cathepsin B precursor 0.1047 0.1418 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0033 0.0023 0.0056
Onchocerca volvulus 0.0127 0.0153 0.1439
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0243 0.0313 0.0799
Echinococcus multilocularis dna polymerase eta 0.0019 0.0005 0.0004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0907 0.1224 0.8631
Brugia malayi glutathione reductase 0.0079 0.0087 0.0219
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.014 0.0354
Echinococcus granulosus Niemann Pick C1 protein 0.0437 0.0579 0.1486
Echinococcus granulosus histone deacetylase 6 0.0044 0.004 0.0096
Loa Loa (eye worm) hypothetical protein 0.0088 0.01 0.0251
Echinococcus granulosus histone deacetylase 0.0044 0.004 0.0096
Onchocerca volvulus Glucosylceramidase homolog 0.0128 0.0155 0.1456
Toxoplasma gondii cathepsin CPC2 0.0243 0.0313 0.2189
Brugia malayi RNA recognition motif domain containing protein 0.01 0.0116 0.0293
Loa Loa (eye worm) hypothetical protein 0.0127 0.0153 0.0388
Toxoplasma gondii patched family protein 0.0019 0.0004 0.0008
Brugia malayi Patched family protein 0.0019 0.0004 0.0005
Echinococcus granulosus calpain A 0.0021 0.0007 0.0012
Schistosoma mansoni ap endonuclease 0.0027 0.0015 0.0033
Plasmodium falciparum serine repeat antigen 8 0.0243 0.0313 0.3224
Toxoplasma gondii hypothetical protein 0.0027 0.0016 0.0092
Onchocerca volvulus 0.0019 0.0004 0.0021
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0243 0.0313 0.3224
Echinococcus granulosus chromobox protein 1 0.0039 0.0032 0.0076
Echinococcus granulosus ecdysone induced protein 78C 0.0033 0.0023 0.0055
Loa Loa (eye worm) hypothetical protein 0.0022 0.0008 0.0017
Brugia malayi Cathepsin L-like cysteine proteinase 0.067 0.09 0.2311
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0243 0.0313 0.3224
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1047 0.1418 0.3644
Brugia malayi AMP-binding enzyme family protein 0.0127 0.0153 0.0387
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0034 0.0026 0.0041
Leishmania major DNA polymerase kappa, putative 0.0019 0.0005 0.0012
Onchocerca volvulus 0.0721 0.097 0.9236
Entamoeba histolytica cysteine protease, putative 0.0294 0.0382 0.3915
Schistosoma mansoni cpg binding protein 0.0044 0.0038 0.0093
Schistosoma mansoni microtubule-associated protein tau 0.2309 0.3151 0.8108

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 50 um PUBCHEM_BIOASSAY: Tumor Hsp90 Inhibitors Dose Response Confirmation. (Class of assay: confirmatory) [Related pubchem assays: 429 (Primary screen preceding this dose response confirmation assay.)] ChEMBL. No reference
Potency (functional) 5.2213 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (binding) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 63.0957 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) = 79.4328 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.