Detailed information for compound 952109

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 293.36 | Formula: C19H19NO2
  • H donors: 1 H acceptors: 2 LogP: 4.39 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1CC(C)(C)c2c3c1[nH]c1c3c(cc2)cc(c1=O)C(C)C
  • InChi: 1S/C19H19NO2/c1-9(2)11-7-10-5-6-12-15-14(10)17(18(11)22)20-16(15)13(21)8-19(12,3)4/h5-7,9,20H,8H2,1-4H3
  • InChiKey: NTCFZQOODYXOGM-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0041 0.0119 0.0464
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0092 0.0402 0.0972
Trypanosoma cruzi cysteine peptidase, putative 0.0138 0.0655 0.1966
Brugia malayi Pre-SET motif family protein 0.0625 0.334 0.3337
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0041 0.0119 0.1221
Echinococcus granulosus protein jagged 2 0.0042 0.0127 0.0124
Brugia malayi Protein kinase domain containing protein 0.0532 0.2829 0.2825
Loa Loa (eye worm) animal heme peroxidase 0.0328 0.1705 0.1701
Schistosoma mansoni septate junction protein 0.0042 0.0127 0.0118
Loa Loa (eye worm) hypothetical protein 0.0042 0.0127 0.0123
Schistosoma mansoni hypothetical protein 0.0042 0.0127 0.0118
Loa Loa (eye worm) hypothetical protein 0.0328 0.1705 0.1701
Trichomonas vaginalis glucosylceramidase, putative 0.0504 0.2677 0.6472
Echinococcus granulosus insulin receptor 0.0588 0.3137 0.3135
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0224 0.0221
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0081 0.0195
Plasmodium falciparum serine repeat antigen 5 0.0041 0.0119 0.1221
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0084 0.0358 0.099
Loa Loa (eye worm) TK/KIN16 protein kinase 0.032 0.1658 0.1655
Giardia lamblia Cathepsin L precursor 0.0041 0.0119 0.0643
Leishmania major heat shock protein 83-1 0.0045 0.0139 0.1161
Brugia malayi cathepsin L precursor 0.0041 0.0119 0.0115
Leishmania major heat shock protein 83-1 0.0045 0.0139 0.1161
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.0494 0.8759
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0092 0.0402 0.0972
Brugia malayi jmjC domain containing protein 0.0046 0.0148 0.0144
Brugia malayi CXXC zinc finger family protein 0.0085 0.0365 0.0361
Schistosoma mansoni nephrin 0.0024 0.0024 0.0015
Echinococcus multilocularis lamin 0.0026 0.0038 0.0035
Onchocerca volvulus 0.0092 0.0402 0.0807
Trypanosoma cruzi major cysteine proteinase, putative 0.0087 0.0372 0.1037
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0092 0.0402 0.0972
Trichomonas vaginalis glucosylceramidase, putative 0.0504 0.2677 0.6472
Plasmodium falciparum thioredoxin reductase 0.0048 0.0156 0.1688
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0092 0.0402 0.0972
Echinococcus granulosus twitchin 0.0024 0.0024 0.0021
Entamoeba histolytica cysteine protease, putative 0.0084 0.0358 0.1593
Echinococcus granulosus neural cadherin 0.0042 0.0127 0.0124
Echinococcus granulosus inositol monophosphatase 1 0.0073 0.0297 0.0294
Onchocerca volvulus 0.0042 0.0127 0.0225
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.0494 0.8759
Giardia lamblia Cathepsin B precursor 0.0208 0.1042 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0021 0.0017
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0021 0.0017
Echinococcus granulosus neurogenic locus notch protein 0.0042 0.0127 0.0124
Onchocerca volvulus Tyrosine kinase homolog 0.03 0.1547 0.3233
Echinococcus multilocularis methyl CpG binding domain protein 2 0.005 0.0171 0.0168
Schistosoma mansoni hypothetical protein 0.1171 0.6354 0.6351
Trichomonas vaginalis glucosylceramidase, putative 0.0769 0.4136 1
Loa Loa (eye worm) hypothetical protein 0.0328 0.1705 0.1701
Brugia malayi Matrixin family protein 0.0069 0.0272 0.0268
Onchocerca volvulus 0.0048 0.0159 0.0292
Plasmodium falciparum endoplasmin, putative 0.0032 0.0072 0.0634
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0021 0.0007
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0041 0.0119 0.0287
Schistosoma mansoni zinc finger protein 0.0045 0.0143 0.0134
Entamoeba histolytica transcription factor BTF3, putative 0.0034 0.0081 0.0284
Loa Loa (eye worm) hypothetical protein 0.0328 0.1705 0.1701
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0148 0.0711 0.0707
Schistosoma mansoni lamin 0.0026 0.0038 0.003
Loa Loa (eye worm) notch protein 0.0042 0.0127 0.0123
Schistosoma mansoni myelin transcription factor 1 myt1 0.0107 0.0483 0.0474
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0107 0.0483 0.0479
Leishmania major cathepsin L-like protease 0.0092 0.0402 0.3734
Trypanosoma brucei ISWI complex protein 0.0045 0.0143 0.1195
Loa Loa (eye worm) hypothetical protein 0.0042 0.0127 0.0123
Brugia malayi Cathepsin L-like precursor 0.0049 0.0163 0.0158
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0084 0.0358 0.035
Schistosoma mansoni sex comb on midleg homolog 0.0094 0.0411 0.0403
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0081 0.008
Plasmodium vivax heat shock protein, putative 0.0169 0.0826 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0091 0.0396 0.368
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0038 0.0104 0.01
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0208 0.1042 0.1034
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0042 0.0127 0.0118
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0092 0.0402 0.4736
Echinococcus granulosus roundabout 2 0.003 0.0058 0.0055
Echinococcus multilocularis heat shock protein 0.0045 0.0139 0.0136
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.008 0.0583
Echinococcus granulosus histone acetyltransferase MYST2 0.0107 0.0483 0.0479
Loa Loa (eye worm) TK/EGFR protein kinase 0.1831 1 1
Leishmania major trypanothione reductase 0.0048 0.0156 0.1331
Onchocerca volvulus 0.0091 0.0396 0.0796
Echinococcus multilocularis epidermal growth factor receptor 0.1831 1 1
Trypanosoma brucei heat shock protein, putative 0.0045 0.0139 0.1161
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0092 0.0402 0.0972
Echinococcus granulosus cpg binding protein 0.0096 0.0423 0.042
Loa Loa (eye worm) hypothetical protein 0.0042 0.0127 0.0123
Trypanosoma cruzi Heat shock protein 83, putative 0.0045 0.0139 0.0271
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0142 0.0675 0.0666
Brugia malayi beta-NAC-like protein 0.0034 0.0081 0.0077
Echinococcus multilocularis neural cadherin 0.0042 0.0127 0.0124
Brugia malayi Inositol-1 0.0073 0.0297 0.0293
Schistosoma mansoni hypothetical protein 0.0042 0.0127 0.0118
Entamoeba histolytica hypothetical protein 0.0036 0.0094 0.0344
Trichomonas vaginalis glucosylceramidase, putative 0.0769 0.4136 1
Loa Loa (eye worm) heat shock protein 75 0.003 0.0057 0.0052
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0041 0.0119 0.0287
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0166 0.1805
Plasmodium vivax SET domain protein, putative 0.0091 0.0396 0.4668
Giardia lamblia Cathepsin L-like protease 0.0041 0.0119 0.0643
Entamoeba histolytica hypothetical protein 0.0041 0.0119 0.0464
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0055 0.0433
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0055 0.0047
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0107 0.0483 0.0479
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0185 0.0913 0.091
Leishmania major heat shock protein 83-1 0.0045 0.0139 0.1161
Schistosoma mansoni tyrosine kinase 0.0986 0.5333 0.5329
Echinococcus multilocularis neurogenic locus protein delta 0.0042 0.0127 0.0124
Schistosoma mansoni hypothetical protein 0.0042 0.0127 0.0118
Mycobacterium ulcerans hypothetical protein 0.0023 0.0021 0.0007
Plasmodium vivax endoplasmin, putative 0.0045 0.0139 0.1473
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0042 0.0124 0.1013
Entamoeba histolytica cysteine protease, putative 0.0041 0.0119 0.0464
Loa Loa (eye worm) hypothetical protein 0.0042 0.0127 0.0123
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.025 0.1271 0.1268
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0048 0.0161 0.0388
Brugia malayi Animal haem peroxidase family protein 0.0328 0.1705 0.1701
Onchocerca volvulus 0.0092 0.0402 0.0807
Toxoplasma gondii NAC domain-containing protein 0.0034 0.0081 0.059
Echinococcus granulosus mixed lineage leukemia protein mll 0.0025 0.0028 0.0025
Entamoeba histolytica cysteine protease, putative 0.0084 0.0358 0.1593
Echinococcus multilocularis Protein lozenge 0.011 0.0501 0.0498
Loa Loa (eye worm) hypothetical protein 0.0069 0.0272 0.0268
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0048 0.0161 0.1371
Leishmania major cysteine peptidase A (CPA) 0.0092 0.0402 0.3734
Onchocerca volvulus 0.0097 0.043 0.0868
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0041 0.0119 0.1221
Schistosoma mansoni hypothetical protein 0.0029 0.0055 0.0047
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.0655 0.6217
Entamoeba histolytica cysteine proteinase, putative 0.0084 0.0358 0.1593
Loa Loa (eye worm) hypothetical protein 0.0328 0.1705 0.1701
Plasmodium falciparum serine repeat antigen 2 0.0041 0.0119 0.1221
Echinococcus multilocularis muscleblind protein 0.0145 0.0695 0.0692
Entamoeba histolytica 90 kDa heat shock protein, putative 0.003 0.0057 0.017
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0041 0.0119 0.0287
Schistosoma mansoni jumonji/arid domain-containing protein 0.0046 0.0148 0.0139
Schistosoma mansoni tyrosine kinase 0.0972 0.5255 0.5251
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.003 0.0057 0.0054
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0233 0.0225
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.003 0.0057 0.0076
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0092 0.0402 0.0972
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.0655 0.6217
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0092 0.0402 0.0972
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0041 0.0119 0.011
Schistosoma mansoni hypothetical protein 0.0097 0.043 0.0422
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0388 0.038
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0055 0.0052
Leishmania major heat shock protein 83-1 0.0045 0.0139 0.1161
Plasmodium falciparum serine repeat antigen 3 0.0041 0.0119 0.1221
Schistosoma mansoni cathepsin C 0.0041 0.0119 0.011
Echinococcus granulosus methyl CpG binding domain protein 2 0.005 0.0171 0.0168
Trypanosoma brucei transcription factor BTF3, putative 0.0034 0.0081 0.059
Loa Loa (eye worm) hypothetical protein 0.0041 0.0119 0.0115
Onchocerca volvulus 0.0711 0.3815 0.804
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0156 0.1688
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0092 0.0402 0.0972
Leishmania major heat shock protein 83-1 0.0045 0.0139 0.1161
Onchocerca volvulus Matrilysin homolog 0.0152 0.0734 0.151
Leishmania major hypothetical protein, conserved 0.0049 0.0166 0.1423
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.0166 0.1423
Brugia malayi GCC2 and GCC3 family protein 0.0042 0.0127 0.0123
Echinococcus granulosus fibropellin Ia 0.0042 0.0127 0.0124
Echinococcus multilocularis lamin dm0 0.0026 0.0038 0.0035
Onchocerca volvulus Peroxidase homolog 0.0328 0.1705 0.3568
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0092 0.0402 0.0972
Echinococcus multilocularis SAM and MBT domain containing protein 0.0094 0.0411 0.0408
Loa Loa (eye worm) hypothetical protein 0.0043 0.0132 0.0128
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0388 0.038
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0096 0.0425 0.0422
Trypanosoma cruzi cysteine peptidase, putative 0.0138 0.0655 0.1966
Schistosoma mansoni notch 0.0042 0.0127 0.0118
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0107 0.0483 0.0479
Brugia malayi Cathepsin L-like precursor 0.0092 0.0402 0.0398
Loa Loa (eye worm) hypothetical protein 0.0142 0.0675 0.0671
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.0655 0.6217
Trichomonas vaginalis heat shock protein, putative 0.0032 0.0072 0.0173
Loa Loa (eye worm) hypothetical protein 0.0042 0.0127 0.0123
Toxoplasma gondii cathepsin CPC2 0.0041 0.0119 0.0963
Plasmodium falciparum heat shock protein 90 0.0045 0.0139 0.1473
Echinococcus granulosus dnaJ subfamily B 0.1218 0.6613 0.6612
Schistosoma mansoni hypothetical protein 0.0047 0.0152 0.0143
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0082 0.0346 0.0342
Schistosoma mansoni cathepsin S (C01 family) 0.0041 0.0119 0.011
Schistosoma mansoni endoplasmin 0.0045 0.0139 0.013
Loa Loa (eye worm) hypothetical protein 0.0148 0.0711 0.0707
Trypanosoma brucei heat shock protein 84, putative 0.003 0.0057 0.0352
Brugia malayi Cathepsin L-like precursor 0.0092 0.0402 0.0398
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0092 0.0402 0.0398
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0025 0.0032 0.0028
Trypanosoma brucei cysteine peptidase C (CPC) 0.0208 0.1042 1
Plasmodium falciparum serine repeat antigen 4 0.0041 0.0119 0.1221
Schistosoma mansoni hypothetical protein 0.0101 0.0452 0.0444
Echinococcus multilocularis microtubule associated protein 2 0.136 0.7401 0.74
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0081 0.008
Brugia malayi Cathepsin L-like precursor 0.0043 0.0132 0.0128
Loa Loa (eye worm) hypothetical protein 0.0328 0.1705 0.1701
Leishmania major cathepsin L-like protease 0.0092 0.0402 0.3734
Loa Loa (eye worm) hypothetical protein 0.0041 0.0119 0.0115
Onchocerca volvulus 0.0092 0.0402 0.0807
Echinococcus multilocularis protein jagged 1 0.0042 0.0127 0.0124
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0185 0.0912 0.0904
Loa Loa (eye worm) TK/FAK protein kinase 0.0532 0.2829 0.2825
Echinococcus granulosus cathepsin L 0.0084 0.0358 0.0355
Loa Loa (eye worm) hypothetical protein 0.0042 0.0127 0.0123
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0041 0.0119 0.0643
Schistosoma mansoni heat shock protein 0.0045 0.0139 0.013
Echinococcus granulosus microtubule associated protein 2 0.136 0.7401 0.74
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0084 0.0358 0.0866
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0092 0.0402 0.0972
Loa Loa (eye worm) hypothetical protein 0.0407 0.2139 0.2135
Mycobacterium ulcerans hydrolase 0.0084 0.0355 1
Brugia malayi Cathepsin L-like precursor 0.0092 0.0402 0.0398
Plasmodium vivax unspecified product 0.0043 0.0132 0.1387
Onchocerca volvulus Neurogenic locus notch homolog 0.0042 0.0127 0.0225
Plasmodium falciparum heat shock protein 90, putative 0.0169 0.0826 1
Onchocerca volvulus Slit protein homolog 0.0042 0.0127 0.0225
Trichomonas vaginalis glucosylceramidase, putative 0.0769 0.4136 1
Toxoplasma gondii cathepsin CPC1 0.0041 0.0119 0.0963
Trypanosoma cruzi heat shock protein 90, putative 0.0045 0.0139 0.0271
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0073 0.0297 0.1306
Loa Loa (eye worm) hypothetical protein 0.0042 0.0127 0.0123
Brugia malayi Cathepsin L-like precursor 0.0092 0.0402 0.0398
Leishmania major heat shock protein 83-1 0.0045 0.0139 0.1161
Brugia malayi Matrixin family protein 0.0069 0.0272 0.0268
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0084 0.0355 0.6181
Echinococcus granulosus neurogenic locus notch protein 0.0042 0.0127 0.0124
Brugia malayi mbt repeat family protein 0.0094 0.0411 0.0407
Entamoeba histolytica hypothetical protein 0.0036 0.0094 0.0344
Echinococcus granulosus lamin dm0 0.0026 0.0038 0.0035
Schistosoma mansoni laminin gamma-3 chain 0.0042 0.0127 0.0118
Echinococcus granulosus cathepsin L cysteine protease 0.0084 0.0358 0.0355
Brugia malayi EGF-like domain containing protein 0.0042 0.0127 0.0123
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0233 0.0229
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0582 0.3102 0.3096
Echinococcus granulosus cysteine protease 0.0084 0.0358 0.0355
Schistosoma mansoni cpg binding protein 0.0096 0.0423 0.0414
Echinococcus multilocularis polycomb protein SCMH1 0.0094 0.0411 0.0408
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0163 0.0393
Echinococcus multilocularis protein tyrosine kinase 0.0526 0.2795 0.2792
Giardia lamblia Cathepsin L precursor 0.0041 0.0119 0.0643
Loa Loa (eye worm) hypothetical protein 0.0043 0.0132 0.0128
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0021 0.0017
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0041 0.0119 0.011
Brugia malayi hypothetical protein 0.0049 0.0166 0.0162
Loa Loa (eye worm) hypothetical protein 0.005 0.0172 0.0167
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.009 0.0086
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.0297 0.271
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0066 0.0255 0.4337
Toxoplasma gondii cathepsin CPL 0.0092 0.0402 0.3734
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0388 0.038
Onchocerca volvulus 0.0042 0.0127 0.0225
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0041 0.0119 0.1221
Brugia malayi TAR-binding protein 0.0062 0.0233 0.0229
Leishmania major heat shock protein 83-1 0.0045 0.0139 0.1161
Entamoeba histolytica cysteine protease, putative 0.0084 0.0358 0.1593
Onchocerca volvulus Chorion peroxidase homolog 0.0328 0.1705 0.3568
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0015 0.0012
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0091 0.0396 0.0388
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0041 0.0119 0.011
Schistosoma mansoni heat shock protein 0.0045 0.0139 0.013
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0095 0.0416 0.1181
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0139 0.0271
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0086 0.0368 0.0364
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0092 0.0402 0.0972
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0036 0.0087
Plasmodium falciparum cysteine proteinase falcipain 1 0.0084 0.0358 0.4192
Trypanosoma brucei heat shock protein, putative 0.0045 0.0139 0.1161
Toxoplasma gondii heat shock protein HSP90 0.0045 0.0139 0.1161
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0084 0.0358 0.035
Trypanosoma brucei heat shock protein, putative 0.0045 0.0139 0.1161
Plasmodium vivax vivapain-2 0.0092 0.0402 0.4736
Brugia malayi Cathepsin L-like precursor 0.0049 0.0163 0.0158
Schistosoma mansoni methyl-cpg binding protein mbd 0.005 0.0171 0.0163
Entamoeba histolytica hypothetical protein 0.0036 0.0094 0.0344
Brugia malayi Cadherin domain containing protein 0.0042 0.0127 0.0123
Echinococcus granulosus histone lysine methyltransferase setb 0.0142 0.0675 0.0671
Brugia malayi EGF-like domain containing protein 0.0042 0.0127 0.0123
Brugia malayi latrophilin 2 splice variant baaae 0.0101 0.0452 0.0448
Treponema pallidum heat shock protein 90 0.0042 0.0124 1
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0041 0.0119 0.1221
Loa Loa (eye worm) endoplasmin 0.0045 0.0139 0.0135
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0041 0.0119 0.0287
Schistosoma mansoni cpg binding protein 0.0085 0.0365 0.0356
Leishmania major hypothetical protein, conserved 0.0034 0.008 0.0583
Schistosoma mansoni hypothetical protein 0.0042 0.0127 0.0118
Echinococcus granulosus slit 2 protein 0.0042 0.0127 0.0124
Schistosoma mansoni cathepsin B (C01 family) 0.0041 0.0119 0.011
Plasmodium vivax vivapain-2 0.0092 0.0402 0.4736
Loa Loa (eye worm) fibroinase 0.0092 0.0402 0.0398
Toxoplasma gondii heat shock protein 90, putative 0.0045 0.0139 0.1161
Toxoplasma gondii heat shock protein 75, putative 0.003 0.0057 0.0352
Loa Loa (eye worm) hypothetical protein 0.0047 0.0152 0.0148
Loa Loa (eye worm) bromodomain containing protein 0.0056 0.02 0.0196
Trypanosoma brucei heat shock protein 90, putative 0.0045 0.0139 0.1161
Trypanosoma brucei heat shock protein, putative 0.0045 0.0139 0.1161
Brugia malayi Calcitonin receptor-like protein seb-1 0.0148 0.0711 0.0707
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0038 0.0034
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0021 0.0002
Trypanosoma cruzi cysteine peptidase, putative 0.0138 0.0655 0.1966
Schistosoma mansoni endoplasmin 0.0045 0.0139 0.013
Giardia lamblia Hypothetical protein 0.0041 0.0119 0.0643
Loa Loa (eye worm) hypothetical protein 0.0042 0.0127 0.0123
Loa Loa (eye worm) hypothetical protein 0.0124 0.0577 0.0573
Brugia malayi F/Y-rich N-terminus family protein 0.0045 0.014 0.0135
Loa Loa (eye worm) hypothetical protein 0.0042 0.0127 0.0123
Loa Loa (eye worm) hypothetical protein 0.0092 0.0402 0.0398
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0986 0.5333 0.5332
Echinococcus granulosus lysine specific demethylase 5A 0.0046 0.0148 0.0144
Loa Loa (eye worm) hypothetical protein 0.0328 0.1705 0.1701
Onchocerca volvulus 0.0878 0.474 1
Schistosoma mansoni tyrosine kinase 0.0588 0.3137 0.3131
Leishmania major cathepsin L-like protease 0.0092 0.0402 0.3734
Leishmania major heat shock protein 83-1 0.0045 0.0139 0.1161
Loa Loa (eye worm) hypothetical protein 0.0328 0.1705 0.1701
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0084 0.0355 0.0351
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0021 0.0007
Giardia lamblia Cysteine protease 0.0041 0.0119 0.0643
Giardia lamblia Cathepsin B precursor 0.0041 0.0119 0.0643
Echinococcus multilocularis fat cadherin tumor suppressor 0.0042 0.0127 0.0124
Onchocerca volvulus 0.0069 0.0272 0.0532
Giardia lamblia Cathepsin B precursor 0.0041 0.0119 0.0643
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0119 0.0287
Echinococcus granulosus epidermal growth factor receptor 0.1831 1 1
Brugia malayi Cadherin domain containing protein 0.0042 0.0127 0.0123
Schistosoma mansoni inositol monophosphatase 0.0073 0.0297 0.0289
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0041 0.0119 0.1221
Giardia lamblia Cathepsin L-like protease 0.0041 0.0119 0.0643
Brugia malayi cathepsin Z-like cysteine proteinase 0.0041 0.0119 0.0115
Brugia malayi cathepsin F-like cysteine proteinase 0.0043 0.0132 0.0128
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0106 0.0479 0.0476
Schistosoma mansoni cathepsin F (C01 family) 0.0092 0.0402 0.0393
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.0655 0.6217
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0185 0.0913 0.091
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0043 0.0132 0.0128
Loa Loa (eye worm) jmjC domain-containing protein 0.0046 0.0148 0.0144
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0041 0.0119 0.0115
Leishmania major basic transcription factor 3a, putative 0.0034 0.0081 0.059
Onchocerca volvulus 0.0085 0.0365 0.0729
Onchocerca volvulus 0.0042 0.0127 0.0225
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0066 0.0255 0.4337
Brugia malayi Papain family cysteine protease containing protein 0.0041 0.0119 0.0115
Loa Loa (eye worm) hypothetical protein 0.0042 0.0127 0.0123
Trypanosoma brucei heat shock protein, putative 0.0045 0.0139 0.1161
Schistosoma mansoni notch 0.0042 0.0127 0.0118
Trypanosoma brucei heat shock protein 90, putative 0.0045 0.0139 0.1161
Brugia malayi cathepsin F-like cysteine proteinase 0.0041 0.0119 0.0115
Loa Loa (eye worm) CXXC zinc finger family protein 0.0085 0.0365 0.0361
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0021 0.0001
Echinococcus granulosus muscleblind protein 0.0145 0.0695 0.0692
Echinococcus granulosus delta-like protein 1 0.0042 0.0127 0.0124
Schistosoma mansoni cathepsin F (C01 family) 0.0049 0.0163 0.0154
Loa Loa (eye worm) animal heme peroxidase 0.0328 0.1705 0.1701
Echinococcus granulosus neurogenic locus notch protein 4 0.0042 0.0127 0.0124
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0092 0.0402 0.0972
Loa Loa (eye worm) hypothetical protein 0.0049 0.0163 0.0158
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0233 0.0229
Echinococcus multilocularis transcription factor btf3 0.0034 0.0081 0.0077
Loa Loa (eye worm) matrixin family protein 0.0152 0.0734 0.073
Loa Loa (eye worm) hypothetical protein 0.0328 0.1705 0.1701
Echinococcus multilocularis protein jagged 2 0.0042 0.0127 0.0124
Leishmania major cathepsin L-like protease 0.0092 0.0402 0.3734
Onchocerca volvulus Dual oxidase homolog 0.0328 0.1705 0.3568
Echinococcus granulosus cathepsin l1 0.0092 0.0402 0.0398
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.0166 0.1805
Echinococcus granulosus GPCR family 2 0.0047 0.0152 0.0148
Loa Loa (eye worm) hypothetical protein 0.0049 0.0166 0.0162
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0588 0.3137 0.3135
Brugia malayi Papain family cysteine protease containing protein 0.0041 0.0119 0.0115
Leishmania major cathepsin L-like protease 0.0138 0.0655 0.6217
Schistosoma mansoni methyl-cpg binding protein mbd 0.005 0.0171 0.0163
Toxoplasma gondii preprocathepsin c precursor, putative 0.0041 0.0119 0.0963
Loa Loa (eye worm) hypothetical protein 0.0041 0.0119 0.0115
Giardia lamblia Cathepsin B precursor 0.0208 0.1042 1
Brugia malayi Calcium binding EGF domain containing protein 0.0042 0.0127 0.0123
Loa Loa (eye worm) MBCTL1 0.0107 0.0483 0.0479
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0208 0.1042 0.2518
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0233 0.0225
Brugia malayi Calcium binding EGF domain containing protein 0.0042 0.0127 0.0123
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0233 0.0225
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0224 0.6095
Loa Loa (eye worm) cysteine protease 0.0092 0.0402 0.0398
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0041 0.0119 0.0287
Loa Loa (eye worm) hypothetical protein 0.0049 0.0163 0.0158
Loa Loa (eye worm) hypothetical protein 0.0041 0.0119 0.0115
Entamoeba histolytica cysteine protease, putative 0.0084 0.0358 0.1593
Loa Loa (eye worm) hypothetical protein 0.0082 0.0346 0.0342
Echinococcus multilocularis GPCR, family 2 0.0047 0.0152 0.0148
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.008 0.0077
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.0655 0.6217
Schistosoma mansoni lamin 0.0026 0.0038 0.003
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0071 0.0288 0.0279
Loa Loa (eye worm) hypothetical protein 0.0121 0.0561 0.0557
Onchocerca volvulus Cathepsin F homolog 0.0092 0.0402 0.0807
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0142 0.0675 0.0666
Onchocerca volvulus Matrix metalloproteinase homolog 0.0152 0.0734 0.151
Echinococcus multilocularis cysteine protease 0.0092 0.0402 0.0398
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0148 0.0711 0.0707
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0103 0.1022
Schistosoma mansoni hypothetical protein 0.0047 0.0152 0.0143
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0021 0.0007
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0055 0.0342
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0073 0.0297 1
Entamoeba histolytica cysteine protease, putative 0.0084 0.0358 0.1593
Leishmania major heat shock protein 83-1 0.0045 0.0139 0.1161
Echinococcus granulosus heat shock protein 90 0.0045 0.0139 0.0136
Brugia malayi Pre-SET motif family protein 0.0091 0.0396 0.0392
Entamoeba histolytica cysteine protease, putative 0.0084 0.0358 0.1593
Echinococcus granulosus peregrin 0.004 0.0113 0.011
Schistosoma mansoni notch 0.0042 0.0127 0.0118
Plasmodium falciparum serine repeat antigen 7 0.0041 0.0119 0.1221
Trypanosoma cruzi ISWI complex protein 0.0045 0.0143 0.0283
Echinococcus granulosus protein tyrosine kinase 0.0526 0.2795 0.2792
Trypanosoma cruzi cysteine protease, putative 0.0084 0.0358 0.099
Schistosoma mansoni hypothetical protein 0.0042 0.0127 0.0118
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0208 0.1042 0.3234
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0152 0.0148
Entamoeba histolytica cysteine proteinase, putative 0.0084 0.0358 0.1593
Echinococcus granulosus lamin 0.0026 0.0038 0.0035
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0041 0.0119 0.0643
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.0388 0.0384
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0041 0.0119 0.0287
Brugia malayi hypothetical protein 0.0878 0.474 0.4738
Echinococcus granulosus cathepsin L cysteine proteinase 0.0092 0.0402 0.0398
Mycobacterium tuberculosis Probable reductase 0.0109 0.0494 0.8759
Echinococcus granulosus zinc finger protein 0.0066 0.0258 0.0255
Brugia malayi hypothetical protein 0.0032 0.0069 0.0065
Brugia malayi Animal haem peroxidase family protein 0.0333 0.1731 0.1728
Echinococcus multilocularis geminin 0.1171 0.6354 0.6353
Loa Loa (eye worm) hypothetical protein 0.0094 0.0411 0.0407
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0092 0.0402 0.4736
Onchocerca volvulus 0.0281 0.1441 0.301
Brugia malayi Protein kinase domain containing protein 0.0588 0.3137 0.3134
Plasmodium vivax serine-repeat antigen (SERA) 0.0041 0.0119 0.1221
Onchocerca volvulus 0.0042 0.0127 0.0225
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0119 0.0287
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0139 0.0271
Schistosoma mansoni peroxidasin 0.0328 0.1705 0.1697
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.0297 0.271
Brugia malayi Augmenter of liver regeneration 0.0034 0.008 0.0076
Brugia malayi acetyltransferase, GNAT family protein 0.0148 0.071 0.0706
Loa Loa (eye worm) hypothetical protein 0.0042 0.0127 0.0123
Giardia lamblia Cathepsin L precursor 0.0041 0.0119 0.0643
Trypanosoma cruzi cysteine peptidase, putative 0.0092 0.0402 0.1134
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.0388 0.0384
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0094 0.0085
Leishmania major heat shock protein 83-1 0.0045 0.0139 0.1161
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0152 0.0148
Loa Loa (eye worm) ICD-1 protein 0.0034 0.0081 0.0077
Brugia malayi heat shock protein 90 0.0045 0.0139 0.0135
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0073 0.0297 0.0719
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0388 0.0385
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0042 0.0124 0.3738
Giardia lamblia Grp94/Hsp90 0.0042 0.0124 0.0695
Leishmania major heat shock protein, putative 0.003 0.0057 0.0352
Brugia malayi glutathione reductase 0.0048 0.0156 0.0152
Trypanosoma brucei trypanothione reductase 0.0048 0.0156 0.1331
Trypanosoma brucei heat shock protein, putative 0.0045 0.0139 0.1161
Schistosoma mansoni cathepsin s 0.0043 0.0132 0.0124
Trichomonas vaginalis glucosylceramidase, putative 0.0769 0.4136 1
Onchocerca volvulus Matrilysin homolog 0.0069 0.0272 0.0532
Giardia lamblia Cathepsin L precursor 0.0041 0.0119 0.0643
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.0297 0.079
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0041 0.0119 0.0115
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0121 0.0561 1
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0042 0.0127 0.0123
Echinococcus multilocularis notch 0.0042 0.0127 0.0124
Plasmodium vivax unspecified product 0.0084 0.0358 0.4192
Brugia malayi mbt repeat family protein 0.0094 0.0411 0.0407
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0233 0.023
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0025 0.0028 0.0025
Schistosoma mansoni notch 0.0042 0.0127 0.0118
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0092 0.0402 0.0972
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0041 0.0119 0.1221
Leishmania major cathepsin L-like protease 0.0092 0.0402 0.3734
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0092 0.0402 0.0398
Schistosoma mansoni heat shock protein 0.003 0.0057 0.0048
Schistosoma mansoni sex comb on midleg homolog 0.0094 0.0411 0.0403
Echinococcus multilocularis cathepsin L cysteine protease 0.0092 0.0402 0.0398
Echinococcus multilocularis neurogenic locus notch protein 0.0042 0.0127 0.0124
Schistosoma mansoni tyrosine kinase 0.0588 0.3137 0.3131
Plasmodium vivax unspecified product 0.0041 0.0119 0.1221
Onchocerca volvulus 0.0082 0.0346 0.069
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0021 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0092 0.0402 0.0972
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0224 0.1994
Onchocerca volvulus 0.0328 0.1705 0.3568
Trypanosoma cruzi heat shock protein 85, putative 0.0038 0.0104 0.0154
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0038 0.0034
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0103 0.0481
Loa Loa (eye worm) hypothetical protein 0.0042 0.0127 0.0123
Echinococcus granulosus neurogenic locus protein delta 0.0042 0.0127 0.0124
Schistosoma mansoni tyrosine kinase 0.0025 0.0032 0.0023
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.008 0.0077
Leishmania major heat shock protein 83-1 0.0045 0.0139 0.1161
Giardia lamblia Hypothetical protein 0.0041 0.0119 0.0643
Schistosoma mansoni notch 0.0042 0.0127 0.0118
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0041 0.0119 0.0643
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0021 0.5
Loa Loa (eye worm) TK/INSR protein kinase 0.0588 0.3137 0.3134
Schistosoma mansoni jumonji/arid domain-containing protein 0.0046 0.0148 0.0139
Trypanosoma brucei heat shock protein, putative 0.0045 0.0139 0.1161
Echinococcus granulosus cathepsin b 0.0582 0.3102 0.31
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0121 0.0561 1
Echinococcus granulosus neuroglian 0.0024 0.0024 0.0021
Echinococcus granulosus tumor protein p63 0.0329 0.1708 0.1705
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0041 0.0119 0.011
Loa Loa (eye worm) runx1 0.011 0.0501 0.0497
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0092 0.0402 0.0972
Onchocerca volvulus Glucosylceramidase homolog 0.0504 0.2677 0.5628
Brugia malayi notch-like transmembrane receptor 0.0042 0.0127 0.0123
Onchocerca volvulus Alhambra homolog 0.0029 0.0055 0.0073
Loa Loa (eye worm) hypothetical protein 0.0023 0.0021 0.0017
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0021 0.0002
Echinococcus granulosus protein jagged 2 0.0042 0.0127 0.0124
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0042 0.0124 0.1914
Loa Loa (eye worm) hypothetical protein 0.0026 0.0036 0.0032
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0096 0.0425 0.0422
Loa Loa (eye worm) hypothetical protein 0.0328 0.1705 0.1701
Entamoeba histolytica cysteine proteinase 1, putative 0.0084 0.0358 0.1593
Brugia malayi Hemopexin family protein 0.0097 0.043 0.0426
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0407 0.2139 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.0297 0.079
Loa Loa (eye worm) heat shock protein 90 0.0045 0.0139 0.0135
Onchocerca volvulus Cathepsin L homolog 0.0092 0.0402 0.0807
Brugia malayi Animal haem peroxidase family protein 0.0328 0.1705 0.1701
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0119 0.0287
Loa Loa (eye worm) hypothetical protein 0.0025 0.0032 0.0027
Loa Loa (eye worm) hypothetical protein 0.0084 0.0355 0.0351
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0109 0.0494 0.8759
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0041 0.0119 0.011
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0015 0.0012
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0228 0.0224
Brugia malayi intermediate filament protein 0.0026 0.0038 0.0034
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.0655 0.6217
Echinococcus granulosus heat shock protein 90 0.0038 0.0104 0.01
Trichomonas vaginalis glucosylceramidase, putative 0.0769 0.4136 1
Brugia malayi Papain family cysteine protease containing protein 0.0092 0.0402 0.0398
Echinococcus granulosus histone acetyltransferase KAT2B 0.0048 0.0161 0.0157
Loa Loa (eye worm) hypothetical protein 0.0023 0.0021 0.0017
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0055 0.0051
Echinococcus multilocularis neurogenic locus protein delta 0.0042 0.0127 0.0124
Onchocerca volvulus 0.0094 0.0411 0.0827
Onchocerca volvulus Huntingtin homolog 0.0121 0.0561 0.1145
Trypanosoma cruzi cysteine proteinase, putative 0.0084 0.0358 0.099
Onchocerca volvulus 0.0328 0.1705 0.3568
Echinococcus multilocularis insulin receptor 0.0588 0.3137 0.3135
Brugia malayi Calcium binding EGF domain containing protein 0.0042 0.0127 0.0123
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0156 0.2515
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.008 0.0583
Trypanosoma cruzi cruzipain precursor, putative 0.0138 0.0655 0.1966
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0048 0.0161 0.1371
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0092 0.0402 0.0972
Brugia malayi Thioredoxin reductase 0.0048 0.0156 0.0152
Leishmania major hypothetical protein, conserved 0.0045 0.0143 0.1195
Echinococcus multilocularis cathepsin b 0.0582 0.3102 0.31
Schistosoma mansoni notch 0.0042 0.0127 0.0118
Plasmodium falciparum basic transcription factor 3b, putative 0.0034 0.0081 0.0748
Loa Loa (eye worm) hypothetical protein 0.0041 0.0119 0.0115
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0038 0.0034
Entamoeba histolytica hypothetical protein 0.0034 0.0081 0.0284
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0224 0.1994
Schistosoma mansoni tyrosine kinase 0.0526 0.2795 0.2789
Entamoeba histolytica cysteine proteinase, putative 0.0084 0.0358 0.1593
Plasmodium falciparum serine repeat antigen 6 0.0041 0.0119 0.1221
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0021 0.0004
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0091 0.0396 0.0388
Entamoeba histolytica cysteine proteinase, putative 0.0049 0.0163 0.0671
Echinococcus multilocularis muscleblind protein 1 0.0145 0.0695 0.0692
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0025 0.0028 0.0025
Onchocerca volvulus 0.0026 0.0038 0.0037
Schistosoma mansoni cell polarity protein 0.0042 0.0127 0.0118
Loa Loa (eye worm) PHD-finger family protein 0.0061 0.023 0.0225
Plasmodium vivax heat shock protein 86, putative 0.0045 0.0139 0.1473
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0041 0.0119 0.1221
Loa Loa (eye worm) hypothetical protein 0.0209 0.1047 0.1043
Toxoplasma gondii histone lysine methyltransferase SET1 0.0176 0.0863 0.8249
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0092 0.0402 0.0972
Trypanosoma brucei Heat shock protein 83, putative 0.0045 0.0139 0.1161
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0073 0.0297 0.271
Plasmodium falciparum cysteine proteinase falcipain 3 0.0092 0.0402 0.4736
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0041 0.0119 0.011
Echinococcus granulosus cathepsin l1 0.0049 0.0163 0.0159
Entamoeba histolytica cysteine proteinase 2 0.0084 0.0358 0.1593
Brugia malayi Muscleblind-like protein 0.0145 0.0695 0.0691
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0041 0.0119 0.0643
Giardia lamblia Cysteine protease 0.0041 0.0119 0.0643
Echinococcus granulosus tar DNA binding protein 0.0062 0.0233 0.023
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0166 0.0359
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0081 0.0195
Giardia lamblia Cysteine protease 0.0041 0.0119 0.0643
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0094 0.009
Echinococcus multilocularis peroxidasin 0.0339 0.1765 0.1762
Echinococcus multilocularis heat shock protein 90 0.0045 0.0139 0.0136
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0407 0.2139 1
Echinococcus granulosus heat shock protein 0.0045 0.0139 0.0136
Trichomonas vaginalis heat shock protein, putative 0.0038 0.0104 0.0251
Echinococcus multilocularis slit 2 protein 0.0042 0.0127 0.0124
Loa Loa (eye worm) hypothetical protein 0.0043 0.0132 0.0128
Trypanosoma cruzi cysteine proteinase, putative 0.0084 0.0358 0.099
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0041 0.0119 0.0287
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0224 0.0216
Giardia lamblia Encystation-specific protease 0.0041 0.0119 0.0643
Onchocerca volvulus Cathepsin L homolog 0.0041 0.0119 0.0208
Schistosoma mansoni hypothetical protein 0.0036 0.0094 0.0085
Echinococcus multilocularis protein jagged 1 0.0042 0.0127 0.0124
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.0655 0.6217
Onchocerca volvulus 0.0092 0.0402 0.0807
Brugia malayi Hsp90 protein 0.003 0.0057 0.0052
Brugia malayi Bromodomain containing protein 0.0117 0.0537 0.0533
Loa Loa (eye worm) hypothetical protein 0.0339 0.1765 0.1762
Brugia malayi cathepsin B-like cysteine proteinase 0.0582 0.3102 0.3099
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0071 0.0288 0.0284
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0152 0.0148
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0152 0.0148
Plasmodium vivax vivapain-3 0.0084 0.0358 0.4192
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0034 0.0082 0.0073
Toxoplasma gondii Hsp90 domain-containing protein 0.0169 0.0826 0.7885
Echinococcus multilocularis roundabout 2 0.003 0.0058 0.0055
Loa Loa (eye worm) hypothetical protein 0.0134 0.0635 0.0631
Brugia malayi Endoplasmin precursor 0.0045 0.0139 0.0135
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0073 0.0297 0.0719
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0081 0.0195
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0224 0.6095
Brugia malayi Muscle positioning protein 4 0.0042 0.0127 0.0123
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0233 0.0229
Brugia malayi Papain family cysteine protease containing protein 0.0084 0.0358 0.0354
Brugia malayi Delta serrate ligand family protein 0.0042 0.0127 0.0123
Giardia lamblia Cathepsin B precursor 0.0208 0.1042 1
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0156 0.0328
Echinococcus multilocularis heat shock protein 90 0.0038 0.0104 0.01
Brugia malayi EGF-like domain containing protein 0.0042 0.0127 0.0123
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0043 0.0132 0.0128
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0041 0.0119 0.011
Trichomonas vaginalis glucosylceramidase, putative 0.0504 0.2677 0.6472
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0119 0.0287
Trichomonas vaginalis glucosylceramidase, putative 0.0504 0.2677 0.6472
Echinococcus multilocularis histone acetyltransferase MYST2 0.0107 0.0483 0.0479
Echinococcus granulosus cathepsin l cysteine peptidase 0.0092 0.0402 0.0398
Onchocerca volvulus Putative cubilin 0.0042 0.0127 0.0225
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0092 0.0402 0.0972
Brugia malayi cathepsin L-like cysteine proteinase 0.0041 0.0119 0.0115
Schistosoma mansoni cpg binding protein 0.0096 0.0423 0.0414
Schistosoma mansoni slit 0.0042 0.0127 0.0118
Echinococcus multilocularis tumor protein p63 0.0329 0.1708 0.1705
Loa Loa (eye worm) hypothetical protein 0.0042 0.0127 0.0123
Echinococcus granulosus geminin 0.1171 0.6354 0.6353
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.0494 0.8759
Echinococcus granulosus peroxidasin 0.0339 0.1765 0.1762
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0156 0.0152
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0041 0.0119 0.1221
Loa Loa (eye worm) hypothetical protein 0.0582 0.3102 0.3099
Giardia lamblia Cathepsin B precursor 0.0041 0.0119 0.0643
Brugia malayi Peroxidasin 0.0339 0.1765 0.1762
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0092 0.0402 0.0972
Onchocerca volvulus 0.0328 0.1705 0.3568
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0142 0.0675 0.0671
Echinococcus multilocularis 0.0566 0.3015 0.3012
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0582 0.3102 1
Brugia malayi Matrixin family protein 0.0069 0.0272 0.0268
Loa Loa (eye worm) hypothetical protein 0.0113 0.0519 0.0515
Brugia malayi cathepsin L-like precursor 0.0049 0.0163 0.0158
Loa Loa (eye worm) blistered cuticle protein 3 0.0328 0.1705 0.1701
Trichomonas vaginalis glucosylceramidase, putative 0.0769 0.4136 1
Schistosoma mansoni cathepsin F (C01 family) 0.0092 0.0402 0.0393
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0021 0.0007
Schistosoma mansoni hypothetical protein 0.1218 0.6613 0.661
Loa Loa (eye worm) matrix metalloproteinase 0.0069 0.0272 0.0268
Loa Loa (eye worm) glutathione reductase 0.0048 0.0156 0.0152
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0082 0.0346 0.0338
Schistosoma mansoni tyrosine kinase 0.0986 0.5333 0.5329
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0041 0.0119 0.0115
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0159 0.015
Entamoeba histolytica cysteine protease, putative 0.0084 0.0358 0.1593
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.025 0.1271 0.1268
Trichomonas vaginalis glucosylceramidase, putative 0.0532 0.2827 0.6835
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.008 0.074
Schistosoma mansoni lozenge 0.011 0.0501 0.0493
Loa Loa (eye worm) histone methyltransferase 0.003 0.0057 0.0053
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0094 0.009
Toxoplasma gondii thioredoxin reductase 0.0048 0.0156 0.1331
Plasmodium falciparum serine repeat antigen 8 0.0041 0.0119 0.1221
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0148 0.071 0.0702
Entamoeba histolytica cysteine protease, putative 0.0041 0.0119 0.0464
Leishmania major heat shock protein 83-1 0.0045 0.0139 0.1161
Entamoeba histolytica cysteine protease, putative 0.0041 0.0119 0.0464
Echinococcus multilocularis peregrin 0.004 0.0113 0.011
Echinococcus granulosus cathepsin b 0.0582 0.3102 0.31
Echinococcus multilocularis dnaJ subfamily B 0.1218 0.6613 0.6612
Schistosoma mansoni hypothetical protein 0.0047 0.0152 0.0143
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0166 0.1805
Entamoeba histolytica cysteine protease, putative 0.0084 0.0358 0.1593
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0152 0.0148
Brugia malayi jmjC domain containing protein 0.0096 0.0425 0.0421
Entamoeba histolytica cysteine protease, putative 0.0092 0.0402 0.18
Loa Loa (eye worm) cathepsin B 0.0208 0.1042 0.1038
Loa Loa (eye worm) animal heme peroxidase 0.0328 0.1705 0.1701
Onchocerca volvulus 0.0092 0.0402 0.0807
Giardia lamblia Heat shock protein HSP 90-alpha 0.0038 0.0104 0.0488
Schistosoma mansoni hypothetical protein 0.0574 0.3063 0.3057
Loa Loa (eye worm) hypothetical protein 0.0026 0.0038 0.0034
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0041 0.0119 0.0115
Brugia malayi Matrixin family protein 0.0166 0.0809 0.0805
Loa Loa (eye worm) hypothetical protein 0.0042 0.0127 0.0123
Trichomonas vaginalis bromodomain-containing protein, putative 0.0048 0.0161 0.0388
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.0655 0.6217
Entamoeba histolytica heat shock protein 90, putative 0.0045 0.0139 0.056
Echinococcus multilocularis neuroglian 0.0024 0.0024 0.0021
Plasmodium falciparum glutathione reductase 0.0048 0.0156 0.1688
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0041 0.0119 0.1221
Loa Loa (eye worm) hypothetical protein 0.0101 0.0452 0.0448
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0119 0.0116
Echinococcus granulosus polycomb protein SCMH1 0.0094 0.0411 0.0408
Entamoeba histolytica heat shock protein 90, putative 0.0045 0.0139 0.056
Schistosoma mansoni tyrosine kinase 0.0972 0.5255 0.5251
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0048 0.0161 0.1739
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0092 0.0402 0.0398
Leishmania major heat shock protein 83-1 0.0045 0.0139 0.1161
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0582 0.3102 0.3096
Loa Loa (eye worm) hypothetical protein 0.0023 0.0021 0.0017
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.008 0.074
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.003 0.0057 0.0053
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0224 0.0221
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0005
Onchocerca volvulus Peroxidase homolog 0.0328 0.1705 0.3568
Brugia malayi RNA binding protein 0.0062 0.0233 0.0229
Echinococcus multilocularis zinc finger protein 0.0066 0.0258 0.0255
Loa Loa (eye worm) Notch2 0.0042 0.0127 0.0123
Giardia lamblia Heat shock protein HSP 90-alpha 0.0045 0.0139 0.0848
Leishmania major heat shock protein 83-1 0.0045 0.0139 0.1161
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.0494 0.8759
Loa Loa (eye worm) hypothetical protein 0.0328 0.1705 0.1701
Schistosoma mansoni intermediate filament proteins 0.0026 0.0038 0.003
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0388 0.0385
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0374 0.1955 0.1953
Trichomonas vaginalis glucosylceramidase, putative 0.0504 0.2677 0.6472
Brugia malayi cathepsin Z-like cysteine proteinase 0.0041 0.0119 0.0115
Toxoplasma gondii EGF family domain-containing protein 0.0042 0.0127 0.1044
Loa Loa (eye worm) hypothetical protein 0.0145 0.0695 0.0691
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0021 0.0004
Echinococcus multilocularis neurogenic locus notch protein 0.0042 0.0127 0.0124
Schistosoma mansoni hypothetical protein 0.0047 0.0152 0.0143
Trypanosoma cruzi ISWI complex protein 0.0045 0.0143 0.0283
Schistosoma mansoni bromodomain containing protein 0.0195 0.0971 0.0963
Brugia malayi EGF-like domain containing protein 0.0042 0.0127 0.0123
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0092 0.0402 0.0972
Loa Loa (eye worm) hypothetical protein 0.0042 0.0127 0.0123
Echinococcus multilocularis epidermal growth factor receptor 0.0986 0.5333 0.5332
Loa Loa (eye worm) hypothetical protein 0.0029 0.0055 0.0051
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0055 0.0342
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0534 0.053
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0106 0.0479 0.0476
Echinococcus multilocularis cathepsin L 0.0041 0.0119 0.0115
Leishmania major cathepsin L-like protease 0.0138 0.0655 0.6217
Echinococcus multilocularis inositol monophosphatase 1 0.0073 0.0297 0.0294
Trypanosoma cruzi cysteine peptidase, putative 0.0084 0.0358 0.099
Echinococcus granulosus protein jagged 1 0.0042 0.0127 0.0124
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.008 0.0583
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0121 0.0561 1
Entamoeba histolytica hypothetical protein 0.0036 0.0094 0.0344
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0119 0.0287
Brugia malayi Bromodomain containing protein 0.023 0.1162 0.1159
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0041 0.0119 0.0287
Entamoeba histolytica cysteine protease, putative 0.0041 0.0119 0.0464
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0021 0.0007
Loa Loa (eye worm) acetyltransferase 0.0148 0.071 0.0706
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.003 0.0057 0.0054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0041 0.0119 0.0287
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0021 0.0001
Echinococcus granulosus transcription factor btf3 0.0034 0.0081 0.0077
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0769 0.4136 0.4133
Plasmodium vivax vivapain-1 0.0084 0.0358 0.4192
Brugia malayi PHD-finger family protein 0.0029 0.0055 0.0051
Echinococcus multilocularis L aminoadipate semialdehyde 0.0082 0.0346 0.0343
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.008 0.0077
Loa Loa (eye worm) hypothetical protein 0.0042 0.0127 0.0123
Echinococcus multilocularis cpg binding protein 0.0096 0.0423 0.042
Schistosoma mansoni transcription factor btf3 0.0034 0.0081 0.0072
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0224 0.6095
Onchocerca volvulus Huntingtin homolog 0.0121 0.0561 0.1145
Plasmodium vivax basic transcription factor 3b, putative 0.0034 0.0081 0.0748
Echinococcus granulosus protein jagged 1 0.0042 0.0127 0.0124
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0807 0.4346 0.4344
Brugia malayi Immunoglobulin I-set domain containing protein 0.032 0.1658 0.1655
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0092 0.0402 0.0972
Trichomonas vaginalis endoplasmin, putative 0.0032 0.0072 0.0173
Trypanosoma cruzi heat shock protein 90, putative 0.0038 0.0104 0.0154
Giardia lamblia Cathepsin L precursor 0.0041 0.0119 0.0643
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0582 0.3102 0.3096
Loa Loa (eye worm) RNA binding protein 0.0062 0.0233 0.0229
Trichomonas vaginalis heat shock protein, putative 0.0042 0.0124 0.03
Echinococcus granulosus L aminoadipate semialdehyde 0.0082 0.0346 0.0343
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0041 0.0119 0.0464
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0021 0.0004
Echinococcus granulosus fetal alzheimer antigen falz 0.0071 0.0288 0.0284
Onchocerca volvulus Peroxidasin homolog 0.0333 0.1731 0.3624
Giardia lamblia High cysteine protein 0.0042 0.0127 0.0727
Giardia lamblia Cysteine protease 0.0041 0.0119 0.0643
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0769 0.4136 0.4133
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0103 0.0389
Trichomonas vaginalis glucosylceramidase, putative 0.0504 0.2677 0.6472
Brugia malayi EGF-like domain containing protein 0.0042 0.0127 0.0123
Echinococcus granulosus SAM and MBT domain containing protein 0.0094 0.0411 0.0408
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0388 0.0385
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0084 0.0358 0.3305
Loa Loa (eye worm) hypothetical protein 0.0049 0.0163 0.0158
Entamoeba histolytica cysteine protease, putative 0.0084 0.0358 0.1593
Trypanosoma cruzi cruzipain precursor, putative 0.0043 0.0132 0.0249
Brugia malayi Cathepsin L-like cysteine proteinase 0.0049 0.0163 0.0158
Plasmodium falciparum phd finger protein, putative 0.0029 0.0055 0.0433
Schistosoma mansoni hypothetical protein 0.0061 0.023 0.0221
Trypanosoma cruzi cysteine peptidase, putative 0.0043 0.0132 0.0249
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0042 0.0124 0.1914
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0041 0.0119 0.1221
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0021 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0041 0.0119 0.0287
Brugia malayi Blistered cuticle protein 3 0.0328 0.1705 0.1701
Loa Loa (eye worm) hypothetical protein 0.0107 0.0483 0.0479
Loa Loa (eye worm) hypothetical protein 0.0042 0.0127 0.0123
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.065 0.0646
Echinococcus multilocularis cathepsin b 0.0582 0.3102 0.31
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0625 0.334 0.3337
Loa Loa (eye worm) hypothetical protein 0.0042 0.0127 0.0123
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0092 0.0402 0.0972
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.0655 0.6217
Loa Loa (eye worm) hypothetical protein 0.0328 0.1705 0.1701
Schistosoma mansoni tyrosine kinase 0.0972 0.5255 0.5251
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0233 0.0225
Entamoeba histolytica cysteine proteinase, putative 0.0092 0.0402 0.18
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0021 0.0002
Schistosoma mansoni inositol monophosphatase 0.0073 0.0297 0.0289
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0094 0.0411 0.0403
Toxoplasma gondii cathepsin B 0.0208 0.1042 1
Echinococcus granulosus notch 0.0042 0.0127 0.0124
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0092 0.0402 0.0398
Brugia malayi EGF-like domain containing protein 0.0042 0.0127 0.0123
Entamoeba histolytica cysteine protease, putative 0.0041 0.0119 0.0464
Entamoeba histolytica cysteine protease, putative 0.0041 0.0119 0.0464
Schistosoma mansoni microtubule-associated protein tau 0.136 0.7401 0.7398
Trichomonas vaginalis heat shock protein, putative 0.0045 0.0139 0.0336
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0152 0.0148
Echinococcus granulosus intermediate filament protein 0.0026 0.0038 0.0035
Loa Loa (eye worm) hypothetical protein 0.0878 0.474 0.4738
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0534 0.053
Schistosoma mansoni zinc finger protein 0.0066 0.0258 0.025
Schistosoma mansoni hypothetical protein 0.0042 0.0127 0.0118
Brugia malayi hypothetical protein 0.0036 0.0094 0.0089
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0041 0.0119 0.011
Echinococcus granulosus epidermal growth factor receptor 0.0986 0.5333 0.5332
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.0494 0.8759
Brugia malayi hypothetical protein 0.0328 0.1705 0.1701
Giardia lamblia Cathepsin B precursor 0.0041 0.0119 0.0643
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0069 0.0272 0.0263
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0148 0.071 0.0707
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0152 0.0148
Loa Loa (eye worm) hypothetical protein 0.0145 0.0695 0.0691
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0092 0.0402 0.0972
Trichomonas vaginalis set domain proteins, putative 0.0711 0.3815 0.9225
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0139 0.0271
Entamoeba histolytica cysteine proteinase, putative 0.0092 0.0402 0.18
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0224 0.0216
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0041 0.0119 0.011
Loa Loa (eye worm) hypothetical protein 0.003 0.0058 0.0054
Loa Loa (eye worm) hypothetical protein 0.0042 0.0127 0.0123
Loa Loa (eye worm) hypothetical protein 0.0069 0.0272 0.0268
Brugia malayi Papain family cysteine protease containing protein 0.0041 0.0119 0.0115
Loa Loa (eye worm) hepatopoietin HPO2 0.0034 0.008 0.0076
Loa Loa (eye worm) animal heme peroxidase 0.0333 0.1731 0.1728
Loa Loa (eye worm) mbt repeat family protein 0.0094 0.0411 0.0407
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0119 0.0287
Echinococcus multilocularis endoplasmin 0.0042 0.0124 0.0121
Onchocerca volvulus Peroxidasin homolog 0.0333 0.1731 0.3624
Plasmodium falciparum serine repeat antigen 1 0.0041 0.0119 0.1221
Echinococcus multilocularis cathepsin L cysteine protease 0.0092 0.0402 0.0398
Brugia malayi Cathepsin L-like precursor 0.0092 0.0402 0.0398
Loa Loa (eye worm) hypothetical protein 0.0042 0.0127 0.0123
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0163 0.0393
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.0655 0.6217
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0233 0.0225
Trichomonas vaginalis glucosylceramidase, putative 0.0532 0.2827 0.6835
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0388 0.0385
Schistosoma mansoni hypothetical protein 0.1171 0.6354 0.6351
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0041 0.0119 0.1221
Giardia lamblia Cathepsin L precursor 0.0041 0.0119 0.0643
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0374 0.1955 0.1953
Loa Loa (eye worm) hypothetical protein 0.0328 0.1705 0.1701
Brugia malayi fibroinase precursor 0.0041 0.0119 0.0115
Plasmodium falciparum heat shock protein 90, putative 0.0026 0.0036 0.0193
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0021 0.0007
Trichomonas vaginalis inositol monophosphatase, putative 0.0073 0.0297 0.0719
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0021 0.0007
Loa Loa (eye worm) hypothetical protein 0.0069 0.0272 0.0268
Onchocerca volvulus 0.0049 0.0163 0.03
Leishmania major heat shock protein 83-1 0.0045 0.0139 0.1161
Echinococcus multilocularis cathepsin L 0.0084 0.0358 0.0355
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.0655 0.6217
Echinococcus granulosus cathepsin L 0.0041 0.0119 0.0115
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0041 0.0119 0.1221
Echinococcus multilocularis neurogenic locus notch protein 4 0.0042 0.0127 0.0124
Echinococcus multilocularis musashi 0.0026 0.0038 0.0035
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0025 0.0028 0.0025
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.0166 0.1423
Leishmania major cathepsin L-like protease 0.0138 0.0655 0.6217
Onchocerca volvulus Cathepsin L homolog 0.0092 0.0402 0.0807
Schistosoma mansoni hypothetical protein 0.0022 0.0015 0.0007
Plasmodium vivax serine-repeat antigen (SERA) 0.0041 0.0119 0.1221
Loa Loa (eye worm) hypothetical protein 0.0041 0.0119 0.0115
Brugia malayi Animal haem peroxidase family protein 0.0328 0.1705 0.1701
Schistosoma mansoni peroxidasin 0.0334 0.1739 0.1731
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0119 0.0287
Brugia malayi EGF-like domain containing protein 0.0042 0.0127 0.0123
Leishmania major heat shock protein 83-1 0.0045 0.0139 0.1161
Schistosoma mansoni jumonji domain containing protein 0.0077 0.0316 0.0307
Brugia malayi MH2 domain containing protein 0.0116 0.0534 0.053
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.003 0.0057 0.0053
Loa Loa (eye worm) hypothetical protein 0.003 0.0058 0.0054
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0041 0.0119 0.0287
Trypanosoma brucei heat shock protein, putative 0.0045 0.0139 0.1161
Entamoeba histolytica cysteine protease, putative 0.0084 0.0358 0.1593
Trichomonas vaginalis heat shock protein, putative 0.0042 0.0124 0.03
Plasmodium vivax heat shock protein 90, putative 0.003 0.0057 0.0447
Loa Loa (eye worm) hypothetical protein 0.0042 0.0127 0.0123
Loa Loa (eye worm) matrixin family protein 0.0166 0.0809 0.0805
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0084 0.0358 0.0866
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0084 0.0358 0.035
Loa Loa (eye worm) ctsf protein 0.0092 0.0402 0.0398
Mycobacterium leprae PROBABLE HYDROLASE 0.0084 0.0355 0.6181
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0163 0.0793 0.0785
Schistosoma mansoni hypothetical protein 0.0042 0.0127 0.0118
Onchocerca volvulus 0.0092 0.0402 0.0807
Entamoeba histolytica cysteine protease, putative 0.0084 0.0358 0.1593
Plasmodium falciparum serine repeat antigen 9 0.0041 0.0119 0.1221
Brugia malayi Matrixin family protein 0.0069 0.0272 0.0268
Brugia malayi PHD-finger family protein 0.0082 0.0345 0.0341
Entamoeba histolytica cysteine protease, putative 0.0084 0.0358 0.1593
Loa Loa (eye worm) hypothetical protein 0.0878 0.474 0.4738
Echinococcus granulosus endoplasmin 0.0042 0.0124 0.0121
Schistosoma mansoni hypothetical protein 0.0045 0.0143 0.0134
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0582 0.3102 0.3096
Brugia malayi Papain family cysteine protease containing protein 0.0084 0.0358 0.0354
Loa Loa (eye worm) hypothetical protein 0.0328 0.1705 0.1701
Loa Loa (eye worm) hypothetical protein 0.0042 0.0127 0.0123
Schistosoma mansoni tyrosine kinase 0.1831 1 1
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0119 0.0116
Entamoeba histolytica cysteine protease, putative 0.0084 0.0358 0.1593
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0041 0.0119 0.1221
Loa Loa (eye worm) hypothetical protein 0.0048 0.0159 0.0155
Onchocerca volvulus 0.0026 0.0038 0.0037
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0091 0.0396 0.0393
Mycobacterium ulcerans heat shock protein 90 0.0042 0.0124 0.3097
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0084 0.0358 0.3305
Brugia malayi Bromodomain containing protein 0.004 0.0113 0.0109
Schistosoma mansoni cell adhesion molecule 0.0025 0.0032 0.0023
Plasmodium vivax glutathione reductase, putative 0.0048 0.0156 0.1688
Brugia malayi Cathepsin L-like precursor 0.0092 0.0402 0.0398
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0094 0.0411 0.0827
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0156 0.0153
Onchocerca volvulus 0.0041 0.0119 0.0208
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0166 0.0359
Trypanosoma cruzi major cysteine proteinase, putative 0.0041 0.0119 0.0205
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0156 0.0153
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0034 0.008 0.0077
Brugia malayi hypothetical protein 0.0121 0.0561 0.0557
Onchocerca volvulus 0.0042 0.0127 0.0225
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0055 0.0052
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0034 0.008 0.0077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0092 0.0402 0.0972
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0119 0.0287
Leishmania major heat shock protein 83-1 0.0045 0.0139 0.1161
Onchocerca volvulus 0.0092 0.0402 0.0807
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0224 0.3768
Loa Loa (eye worm) hypothetical protein 0.0121 0.0561 0.0557
Echinococcus multilocularis fibropellin Ia 0.0042 0.0127 0.0124
Loa Loa (eye worm) inositol-1 0.0073 0.0297 0.0293
Trichomonas vaginalis glucosylceramidase, putative 0.0504 0.2677 0.6472
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0073 0.0297 0.8285
Mycobacterium tuberculosis Probable oxidoreductase 0.0121 0.0561 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0092 0.0402 0.0972
Entamoeba histolytica cysteine proteinase, putative 0.0084 0.0358 0.1593
Brugia malayi Animal haem peroxidase family protein 0.0328 0.1705 0.1701
Giardia lamblia Cathepsin B precursor 0.0041 0.0119 0.0643
Echinococcus multilocularis cysteine protease 0.0092 0.0402 0.0398
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0208 0.1042 1
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0042 0.0127 0.0225
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0588 0.3137 0.3135

Activities

Activity type Activity value Assay description Source Reference
CD50 (functional) = 137 uM Cytotoxicity against human HepG2 cells by MTT assay ChEMBL. 16038550
CD50 (functional) = 169 uM Cytotoxicity against human OVCAR-3 cells by MTT assay ChEMBL. 16038550
CD50 (functional) = 178 uM Cytotoxicity against human HeLa cells by MTT assay ChEMBL. 16038550

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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