Detailed information for compound 994570

Basic information

Technical information
  • TDR Targets ID: 994570
  • Name: 4,7-dimethoxyphenanthren-2-ol
  • MW: 254.281 | Formula: C16H14O3
  • H donors: 1 H acceptors: 1 LogP: 4.01 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(O)cc2c1c1ccc(cc1cc2)OC
  • InChi: 1S/C16H14O3/c1-18-13-5-6-14-10(8-13)3-4-11-7-12(17)9-15(19-2)16(11)14/h3-9,17H,1-2H3
  • InChiKey: BLEJCVUXRRNLMA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4,7-dimethoxy-2-phenanthrenol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.005 0.0278 0.0297
Brugia malayi Papain family cysteine protease containing protein 0.0015 0.0037 0.0033
Loa Loa (eye worm) hypothetical protein 0.0106 0.0665 0.0747
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0019 0.0065 0.0423
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0055 0.0316 0.2417
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0065 0.0401
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0048 0.0267 0.1717
Mycobacterium tuberculosis Possible dehydrogenase 0.0048 0.0267 0.0283
Entamoeba histolytica cysteine proteinase, putative 0.0015 0.0037 0.07
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0048 0.0267 0.2043
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.005 0.0278 0.0014
Mycobacterium leprae Polyketide synthase Pks13 0.1161 0.7872 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0019 0.0065 0.0083
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0044 0.024 0.1828
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0777 0.5246 0.6645
Echinococcus granulosus cathepsin l1 0.001 0.0004 0.0005
Schistosoma mansoni hypothetical protein 0.0027 0.0119 0.0151
Mycobacterium ulcerans acyl carrier protein 0.0078 0.0473 0.0271
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0019 0.0065 0.1309
Mycobacterium tuberculosis Conserved protein 0.0234 0.1536 0.1905
Onchocerca volvulus Fatty acid synthase homolog 0.1401 0.9507 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0037 0.0214
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.0138 0.0877
Trichomonas vaginalis maltase-glucoamylase, putative 0.0011 0.0012 0.0054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0037 0.0214
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0032 0.0157 0.0199
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0625 0.4209 0.5183
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0777 0.5246 0.6547
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0065 0.0401
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0015 0.0037 0.0037
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0048 0.0267 0.2043
Mycobacterium tuberculosis Possible oxidoreductase FadB5 0.0048 0.0267 0.0283
Echinococcus multilocularis lysosomal alpha glucosidase 0.0133 0.0843 0.1071
Schistosoma mansoni lamin 0.0045 0.0247 0.0314
Brugia malayi ADP-specific Phosphofructokinase/Glucokinase conserved region family protein 0.0049 0.0272 0.0269
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0157 0.0999
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.0078 0.0473 0.0271
Trichomonas vaginalis maltase-glucoamylase, putative 0.0029 0.0138 0.0877
Mycobacterium ulcerans polyketide synthase MbtC 0.0195 0.127 0.1319
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.1161 0.7872 1
Mycobacterium leprae Probable polyketide synthase Pks1 0.0825 0.5576 0.6981
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0195 0.127 0.1319
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0019 0.0065 0.0443
Echinococcus granulosus NADH dehydrogenase 0.0078 0.0473 0.0601
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0015 0.0037 0.0214
Trichomonas vaginalis conserved hypothetical protein 0.0234 0.1536 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0065 0.0401
Trypanosoma brucei Trans-2-enoyl-ACP reductase 2, putative 0.0048 0.0267 0.2027
Echinococcus granulosus AMP dependent ligase 0.0078 0.0473 0.0601
Mycobacterium tuberculosis Probable thioesterase TesA 0.0648 0.4361 0.5514
Brugia malayi Alcohol dehydrogenase class III 0.0048 0.0267 0.0263
Loa Loa (eye worm) hypothetical protein 0.0049 0.0272 0.0303
Toxoplasma gondii histone lysine methyltransferase SET1 0.0051 0.0285 0.048
Brugia malayi Cathepsin L-like precursor 0.0015 0.0037 0.0033
Mycobacterium leprae PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 0.0119 0.0751 0.0637
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0044 0.024 0.1828
Schistosoma mansoni alpha glucosidase 0.0029 0.0138 0.0176
Loa Loa (eye worm) hypothetical protein 0.0084 0.051 0.0572
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0726 0.4897 0.62
Loa Loa (eye worm) acetyltransferase 0.0145 0.0928 0.1044
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0019 0.0065 0.0349
Echinococcus multilocularis ubiquitin specific protease 41 0.0032 0.0157 0.0199
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0048 0.0267 0.2043
Mycobacterium leprae conserved hypothetical protein 0.0078 0.0473 0.0271
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0045 0.0284
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0078 0.0473 0.0547
Echinococcus multilocularis lysosomal alpha glucosidase 0.0133 0.0843 0.1071
Brugia malayi AMP-binding enzyme family protein 0.0239 0.1569 0.1566
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0648 0.4361 0.5384
Mycobacterium ulcerans short-chain dehydrogenase 0.0052 0.029 0.003
Onchocerca volvulus Putative alcohol dehydrogenase 0.0048 0.0267 0.0277
Echinococcus granulosus dnaJ subfamily B 0.0356 0.2366 0.3006
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0078 0.0473 0.0271
Onchocerca volvulus 0.0045 0.0247 0.0256
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0825 0.5576 0.7067
Echinococcus granulosus histone acetyltransferase KAT2B 0.0141 0.09 0.1144
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0065 0.0401
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0048 0.0267 0.5604
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0045 0.0057
Toxoplasma gondii type I fatty acid synthase, putative 0.0825 0.5576 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0019 0.0065 0.0445
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0625 0.4209 0.5183
Leishmania major zinc binding dehydrogenase-like protein 0.0048 0.0267 0.1672
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.0754 0.0847
Brugia malayi N-terminal motif family protein 0.0181 0.1172 0.1168
Leishmania major cathepsin L-like protease 0.0015 0.0037 0.0161
Mycobacterium tuberculosis Probable quinone reductase Qor (NADPH:quinone reductase) (zeta-crystallin homolog protein) 0.0048 0.0267 0.0283
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0011 0.0012 0.0009
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0044 0.024 0.04
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0032 0.0157 0.0199
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0229 0.1467
Mycobacterium tuberculosis Probable oxidoreductase 0.0048 0.0267 0.0283
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0048 0.0267 0.0263
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0065 0.0401
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0113 0.0713
Trichomonas vaginalis alpha-glucosidase, putative 0.0011 0.0012 0.0054
Schistosoma mansoni methyltransferase-related 0.0234 0.1536 0.1952
Onchocerca volvulus 0.1353 0.9178 0.9653
Loa Loa (eye worm) hypothetical protein 0.0032 0.0157 0.0173
Echinococcus granulosus geminin 0.0624 0.4203 0.5339
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0026 0.0113 0.0144
Loa Loa (eye worm) hypothetical protein 0.0045 0.0247 0.0275
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0045 0.005
Entamoeba histolytica hypothetical protein 0.0026 0.0113 0.2328
Schistosoma mansoni [ACP] S-malonyltransferase 0.0049 0.0272 0.0346
Mycobacterium ulcerans polyketide synthase 0.0825 0.5576 0.6981
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.005 0.0278 0.0353
Leishmania major acyl carrier protein, putative 0.0078 0.0473 0.3026
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0037 0.0191 0.0243
Brugia malayi Glycosyl hydrolases family 31 protein 0.0133 0.0843 0.084
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0195 0.127 0.1266
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0195 0.127 1
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0119 0.0751 0.0902
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0065 0.0401
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0065 0.0401
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0009 0.0037
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.005 0.0278 0.1744
Onchocerca volvulus 0.0015 0.0037 0.0035
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0635 0.4279 0.5409
Echinococcus multilocularis mitogen activated protein kinase 3 0.0044 0.024 0.0305
Schistosoma mansoni cpg binding protein 0.0026 0.0117 0.0149
Loa Loa (eye worm) fatty acid synthase 0.0767 0.5176 0.5842
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0009 0.0037
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.0138 0.0877
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0032 0.0157 0.0999
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0045 0.0284
Echinococcus multilocularis cathepsin L cysteine protease 0.0015 0.0037 0.0046
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0037 0.0214
Echinococcus granulosus neutral alpha glucosidase AB 0.0029 0.0138 0.0176
Schistosoma mansoni hypothetical protein 0.0356 0.2366 0.3006
Leishmania major cathepsin L-like protease 0.0015 0.0037 0.0161
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0045 0.0047
Schistosoma mansoni cathepsin F (C01 family) 0.0015 0.0037 0.0046
Onchocerca volvulus 0.0015 0.0037 0.0035
Onchocerca volvulus Cathepsin F homolog 0.0015 0.0037 0.0035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0037 0.0214
Trypanosoma cruzi cruzipain precursor, putative 0.0055 0.0316 0.2433
Trypanosoma brucei oxidoreductase, putative 0.0048 0.0267 0.2027
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0045 0.005
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0015 0.0037 0.0046
Schistosoma mansoni [ACP] S-malonyltransferase 0.0049 0.0272 0.0346
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0029 0.0138 0.0217
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0029 0.0138 0.0152
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0037 0.0214
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0229 0.1467
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0037 0.0191 0.0243
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.0138 0.0877
Mycobacterium tuberculosis Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) 0.0048 0.0267 0.0283
Loa Loa (eye worm) hypothetical protein 0.0048 0.0267 0.0297
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0195 0.127 1
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0047 0.0255 0.0284
Loa Loa (eye worm) hypothetical protein 0.0435 0.2912 0.3285
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0065 0.0401
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0037 0.0191 0.0188
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.0138 0.0877
Mycobacterium ulcerans polyketide synthase 0.0777 0.5246 0.6547
Echinococcus multilocularis NADH dehydrogenase 0.0078 0.0473 0.0601
Brugia malayi Cathepsin L-like precursor 0.0015 0.0037 0.0033
Echinococcus granulosus lysosomal alpha glucosidase 0.0133 0.0843 0.1071
Loa Loa (eye worm) hypothetical protein 0.0048 0.0267 0.0297
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0777 0.5246 0.6645
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0244 0.1605 0.1993
Trypanosoma cruzi PAB1-binding protein , putative 0.0021 0.0077 0.0539
Onchocerca volvulus 0.0042 0.0224 0.0231
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0037 0.0191 0.0243
Trichomonas vaginalis alpha-glucosidase, putative 0.0011 0.0012 0.0054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0037 0.0214
Echinococcus granulosus lamin 0.0045 0.0247 0.0314
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.0088 0.0627
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0045 0.0041
Schistosoma mansoni alpha-glucosidase 0.0114 0.0717 0.0911
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0065 0.0401
Brugia malayi hypothetical protein 0.0021 0.0077 0.0074
Echinococcus granulosus microtubule associated protein 2 0.1162 0.7873 1
Plasmodium falciparum malonyl CoA-acyl carrier protein transacylase 0.0049 0.0272 0.1911
Echinococcus multilocularis microtubule associated protein 2 0.1162 0.7873 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0037 0.0214
Echinococcus granulosus serine protein kinase ATM 0.0026 0.0113 0.0144
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0065 0.0401
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0753 0.5083 0.6437
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0022 0.0087 0.011
Entamoeba histolytica protein kinase rad3, putative 0.0011 0.0009 0.012
Onchocerca volvulus 0.0025 0.0108 0.0109
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0012 0.0018 0.0044
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0032 0.0157 0.1151
Echinococcus granulosus mitogen activated protein kinase 3 0.0044 0.024 0.0305
Brugia malayi MH2 domain containing protein 0.0119 0.0754 0.075
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0442 0.2955 0.3718
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0032 0.0157 0.0949
Schistosoma mansoni hypothetical protein 0.0624 0.4203 0.5339
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0777 0.5246 0.5244
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0037 0.0214
Leishmania major d-xylulose reductase, putative 0.0048 0.0267 0.1672
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0022 0.0087 0.011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0037 0.0214
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0019 0.0065 0.0349
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0011 0.0012 0.0054
Mycobacterium tuberculosis Probable acyl carrier protein AcpA (ACP) 0.0078 0.0473 0.0547
Echinococcus granulosus Malonyl coenzyme A acyl carrier protein transacylase 0.0049 0.0272 0.0346
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0018 0.0091
Trichomonas vaginalis CMGC family protein kinase 0.0044 0.024 0.154
Trypanosoma cruzi cysteine peptidase, putative 0.0055 0.0316 0.2433
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0065 0.0401
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0032 0.0157 0.0199
Mycobacterium ulcerans acyl carrier protein 0.0078 0.0473 0.0271
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0053 0.0299 0.038
Leishmania major beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative 0.0195 0.127 0.825
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0026 0.0113 0.0109
Leishmania major phosphatidylinositol kinase related protein, putative 0.0019 0.0065 0.035
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0825 0.5576 0.6981
Echinococcus granulosus cathepsin l cysteine peptidase 0.0015 0.0037 0.0046
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0055 0.0316 0.2417
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0045 0.007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0065 0.0401
Loa Loa (eye worm) alcohol dehydrogenase class III 0.0048 0.0267 0.0297
Toxoplasma gondii quinone oxidoreductase, putative 0.0048 0.0267 0.0449
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0011 0.0012 0.0054
Mycobacterium ulcerans Type I modular polyketide synthase 0.0777 0.5246 0.6547
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0239 0.1569 0.1947
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0065 0.0401
Brugia malayi Latrophilin receptor protein 2 0.0027 0.0119 0.0115
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0037 0.0214
Loa Loa (eye worm) hypothetical protein 0.0011 0.0012 0.0009
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0078 0.0473 0.0271
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0011 0.0012 0.0021
Mycobacterium tuberculosis Conserved hypothetical protein 0.0078 0.0473 0.0547
Schistosoma mansoni intermediate filament proteins 0.0045 0.0247 0.0314
Loa Loa (eye worm) phosphopantetheine attachment site family protein 0.0078 0.0473 0.0531
Onchocerca volvulus Cathepsin L homolog 0.0015 0.0037 0.0035
Wolbachia endosymbiont of Brugia malayi acyl carrier protein 0.0078 0.0473 0.2059
Echinococcus multilocularis Malonyl coenzyme A acyl carrier protein transacylase 0.0049 0.0272 0.0346
Trypanosoma cruzi acyl transferase-like protein, putative 0.0049 0.0272 0.2086
Leishmania major cathepsin L-like protease 0.0015 0.0037 0.0161
Schistosoma mansoni lamin 0.0045 0.0247 0.0314
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0011 0.0012 0.0021
Schistosoma mansoni alpha-glucosidase 0.0114 0.0717 0.0911
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0044 0.024 0.1494
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0133 0.0843 0.0948
Brugia malayi hypothetical protein 0.0206 0.1341 0.1338
Echinococcus multilocularis Acyl carrier protein, mitochondrial 0.0078 0.0473 0.0601
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0011 0.0009 0.0006
Entamoeba histolytica NADP-dependent alcohol dehydrogenase 0.0048 0.0267 0.5604
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0145 0.0928 0.1179
Schistosoma mansoni cathepsin F (C01 family) 0.0015 0.0037 0.0046
Mycobacterium tuberculosis Probable NADP-dependent alcohol dehydrogenase AdhC 0.0048 0.0267 0.0283
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0825 0.5576 0.6981
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0042 0.0224 0.022
Leishmania major hypothetical protein, conserved 0.0234 0.1536 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0037 0.0191 0.0243
Echinococcus multilocularis lamin 0.0045 0.0247 0.0314
Brugia malayi Methyltransferase-like protein 4 0.0234 0.1536 0.1533
Mycobacterium ulcerans Type I modular polyketide synthase 0.0777 0.5246 0.6547
Echinococcus granulosus survival motor neuron protein 1 0.0206 0.1341 0.1704
Echinococcus multilocularis survival motor neuron protein 1 0.0206 0.1341 0.1704
Mycobacterium ulcerans thioesterase TesA 0.0648 0.4361 0.5384
Echinococcus granulosus mitogen activated protein kinase 0.0044 0.024 0.0305
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0032 0.0157 0.1169
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0055 0.0316 0.2417
Loa Loa (eye worm) hypothetical protein 0.0119 0.0751 0.0845
Echinococcus multilocularis musashi 0.0045 0.0247 0.0314
Leishmania major oxidoreductase, putative 0.0048 0.0267 0.1672
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0119 0.0751 0.0902
Loa Loa (eye worm) hypothetical protein 0.0022 0.0088 0.0096
Plasmodium falciparum acyl carrier protein 0.0078 0.0473 0.3542
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0078 0.0473 0.0271
Toxoplasma gondii 3-oxoacyl-acyl-carrier protein synthase I/II, putative 0.0195 0.127 0.2253
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0037 0.0214
Echinococcus multilocularis cathepsin L cysteine protease 0.0015 0.0037 0.0046
Chlamydia trachomatis acyl carrier protein 0.0078 0.0473 0.2016
Plasmodium falciparum ataxin-2 like protein, putative 0.0021 0.0077 0.033
Echinococcus multilocularis dnaJ subfamily B 0.0356 0.2366 0.3006
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0514 0.3448 0.4183
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0078 0.0473 0.0547
Brugia malayi Phosphopantetheine attachment site family protein 0.0078 0.0473 0.047
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0045 0.0057
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0044 0.024 0.1828
Loa Loa (eye worm) latrophilin receptor protein 2 0.0027 0.0119 0.013
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0032 0.0157 0.1169
Entamoeba histolytica acyl-CoA synthetase, putative 0.0078 0.0473 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0045 0.0057
Echinococcus multilocularis neutral alpha glucosidase AB 0.0029 0.0138 0.0176
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0045 0.0218
Schistosoma mansoni hypothetical protein 0.0027 0.0119 0.0151
Trypanosoma cruzi acyl transferase-like protein 0.0049 0.0272 0.2086
Loa Loa (eye worm) hypothetical protein 0.0021 0.0077 0.0083
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0037 0.0214
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0032 0.0157 0.0622
Echinococcus multilocularis mitochondrial trans 2 enoyl coenzyme A reductase 0.0048 0.0267 0.0339
Schistosoma mansoni microtubule-associated protein tau 0.1162 0.7873 1
Loa Loa (eye worm) hypothetical protein 0.0206 0.1341 0.1511
Loa Loa (eye worm) hypothetical protein 0.0022 0.0087 0.0094
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0045 0.0057
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0065 0.0062
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0045 0.0057
Onchocerca volvulus 0.0015 0.0037 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0065 0.0401
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0825 0.5576 0.6981
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0078 0.0473 0.0547
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0065 0.0401
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0204 0.4271
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0045 0.0057
Brugia malayi hypothetical protein 0.0013 0.0028 0.0024
Loa Loa (eye worm) hypothetical protein 0.0048 0.0267 0.0297
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0145 0.0928 0.1179
Schistosoma mansoni cathepsin F (C01 family) 0.001 0.0004 0.0005
Trichomonas vaginalis CMGC family protein kinase 0.0044 0.024 0.154
Leishmania major cathepsin L-like protease 0.0055 0.0316 0.1994
Schistosoma mansoni zinc binding dehydrogenase 0.0048 0.0267 0.0339
Plasmodium falciparum ataxin-2 like protein, putative 0.0021 0.0077 0.033
Leishmania major cathepsin L-like protease 0.0015 0.0037 0.0161
Chlamydia trachomatis 3-oxoacyl-ACP synthase 0.0195 0.127 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0229 0.038
Mycobacterium ulcerans thioesterase 0.0648 0.4361 0.5384
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0019 0.0065 0.0083
Echinococcus granulosus intermediate filament protein 0.0045 0.0247 0.0314
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0084 0.051 0.0572
Onchocerca volvulus Huntingtin homolog 0.0106 0.0665 0.0696
Onchocerca volvulus 0.0015 0.0037 0.0035
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks4 0.0119 0.0751 0.0902
Leishmania major cathepsin L-like protease 0.0055 0.0316 0.1994
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0029 0.0138 0.2863
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0037 0.0214
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.005 0.0278 0.0353
Mycobacterium ulcerans acyl-CoA synthetase 0.0078 0.0473 0.0271
Echinococcus multilocularis geminin 0.0624 0.4203 0.5339
Echinococcus granulosus cathepsin l1 0.0015 0.0037 0.0046
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0037
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.005 0.0278 0.0014
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0027 0.0119 0.0115
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0009 0.0037
Mycobacterium tuberculosis Probable alcohol dehydrogenase Adh 0.0048 0.0267 0.0283
Onchocerca volvulus Huntingtin homolog 0.0106 0.0665 0.0696
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0045 0.0057
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0181 0.1172 0.1229
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0055 0.0316 0.2417
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0037 0.0214
Leishmania major oxidoreductase-like protein 0.0048 0.0267 0.1672
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0065 0.0401
Brugia malayi Calcitonin receptor-like protein seb-1 0.0084 0.051 0.0507
Trypanosoma cruzi oxidoreductase, putative 0.0048 0.0267 0.2043
Entamoeba histolytica cysteine proteinase, putative 0.0015 0.0037 0.07
Echinococcus multilocularis 3 oxoacyl (acyl carrier protein) synthase 0.0195 0.127 0.1613
Onchocerca volvulus Acyl carrier protein, mitochondrial homolog 0.0078 0.0473 0.0494
Toxoplasma gondii LsmAD domain-containing protein 0.0021 0.0077 0.0107
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0055 0.0316 0.2417
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0065 0.0069
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0029 0.0138 0.0877
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0029 0.0138 0.2863
Giardia lamblia Kinase, CMGC MAPK 0.0044 0.024 0.1186
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0037 0.0214
Trypanosoma brucei Acyl carrier protein, mitochondrial 0.0078 0.0473 0.3668
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0078 0.0473 0.0271
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0027 0.0119 0.0151
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0032 0.0157 0.0199
Echinococcus granulosus ubiquitin specific protease 41 0.0032 0.0157 0.0199
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0019 0.0065 0.0083
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0825 0.5576 0.7067
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0065 0.0401
Schistosoma mansoni acyl carrier protein 0.0078 0.0473 0.0601
Onchocerca volvulus 0.0015 0.0037 0.0035
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0045 0.0264
Leishmania major phosphatidylinositol 3-kinase, putative 0.0019 0.0065 0.0349
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0065 0.0401
Toxoplasma gondii acyl transferase domain-containing protein 0.0049 0.0272 0.0458
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0065 0.0401
Loa Loa (eye worm) fibroinase 0.0015 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0027 0.0119 0.013
Trypanosoma cruzi oxidoreductase, putative 0.0048 0.0267 0.2043
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0019 0.0065 0.0423
Mycobacterium ulcerans fatty acid synthase Fas 0.0244 0.1605 0.1759
Loa Loa (eye worm) acyl carrier protein 0.0078 0.0473 0.0531
Trypanosoma brucei PAB1-binding protein , putative 0.0021 0.0077 0.0519
Onchocerca volvulus 0.0077 0.0461 0.0481
Toxoplasma gondii target of rapamycin (TOR), putative 0.0019 0.0065 0.0086
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0032 0.0157 0.0999
Mycobacterium ulcerans Type I modular polyketide synthase 0.0777 0.5246 0.6547
Echinococcus multilocularis AMP dependent ligase 0.0078 0.0473 0.0601
Loa Loa (eye worm) beta-ketoacyl synthase domain-containing protein 0.0195 0.127 0.143
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0009 0.0037
Echinococcus multilocularis mitogen activated protein kinase 0.0044 0.024 0.0305
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0051 0.0283 0.2172
Leishmania major hypothetical protein, conserved 0.0049 0.0272 0.1707
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0048 0.0267 0.1717
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0009 0.0037
Toxoplasma gondii type I fatty acid synthase 0.0119 0.0751 0.132
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0504 0.3381 0.6051
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0514 0.3448 0.4183
Loa Loa (eye worm) hypothetical protein 0.0057 0.0329 0.0367
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0032 0.0157 0.3259
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0011 0.0009 0.012
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0084 0.051 0.0507
Brugia malayi Intermediate filament tail domain containing protein 0.0045 0.0247 0.0244
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0065 0.0401
Loa Loa (eye worm) hypothetical protein 0.0181 0.1172 0.1319
Brugia malayi hypothetical protein 0.0106 0.0665 0.0661
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0045 0.0264
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0024 0.0103 0.0112
Loa Loa (eye worm) acyl carrier protein 0.0357 0.2378 0.2683
Entamoeba histolytica acyl-CoA synthetase, putative 0.0078 0.0473 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0037 0.0214
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0065 0.0401
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0065 0.0401
Toxoplasma gondii Zn-containing alcohol dehydrogenase 0.0048 0.0267 0.0449
Mycobacterium ulcerans polyketide synthase MbtD 0.0239 0.1569 0.1713
Schistosoma mansoni hypothetical protein 0.0057 0.0329 0.0418
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0055 0.0316 0.2417
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0011 0.0009 0.0012
Echinococcus granulosus cathepsin L cysteine proteinase 0.0015 0.0037 0.0046
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0044 0.024 0.1828
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0204 0.0946
Mycobacterium tuberculosis Polyketide synthase Pks13 0.1161 0.7872 1
Toxoplasma gondii FATC domain-containing protein 0.0026 0.0113 0.0172
Onchocerca volvulus 0.0015 0.0037 0.0035
Trypanosoma brucei beta-ketoacyl-ACP synthase 0.0195 0.127 1
Mycobacterium ulcerans malonyl CoA-acyl carrier protein transacylase FabD 0.0049 0.0272 0.0007
Onchocerca volvulus Cathepsin L homolog 0.0015 0.0037 0.0035
Echinococcus multilocularis cysteine protease 0.0015 0.0037 0.0046
Trichomonas vaginalis alpha-glucosidase, putative 0.0011 0.0012 0.0054
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0009 0.0037
Loa Loa (eye worm) hypothetical protein 0.0048 0.0267 0.0297
Schistosoma mansoni hypothetical protein 0.0078 0.0473 0.0601
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0065 0.0401
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0078 0.0473 0.0547
Loa Loa (eye worm) hypothetical protein 0.0012 0.0018 0.0016
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0019 0.0065 0.1309
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0314 0.2084 0.2605
Echinococcus granulosus cpg binding protein 0.0026 0.0117 0.0149
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.024 0.0305
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0825 0.5576 0.7067
Brugia malayi Glycosyl hydrolases family 31 protein 0.0029 0.0138 0.0135
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0019 0.0065 0.0423
Plasmodium falciparum 3-oxoacyl-acyl-carrier protein synthase I/II 0.0195 0.127 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0055 0.0316 0.2417
Echinococcus multilocularis GPCR, family 2 0.0027 0.0119 0.0151
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0065 0.0069
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0019 0.0065 0.0443
Trypanosoma cruzi major cysteine proteinase, putative 0.0044 0.0235 0.179
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0019 0.0065 0.0423
Onchocerca volvulus 0.0015 0.0037 0.0035
Loa Loa (eye worm) CXXC zinc finger family protein 0.0025 0.0108 0.0117
Schistosoma mansoni 3-oxoacyl-[ACP] synthase 0.0195 0.127 0.1613
Leishmania major cathepsin L-like protease 0.0015 0.0037 0.0161
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0065 0.0401
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0037 0.0214
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0065 0.0401
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0019 0.0065 0.0423
Trichomonas vaginalis CMGC family protein kinase 0.0044 0.024 0.154
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.005 0.0278 0.0353
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0037 0.0191 0.0243
Echinococcus granulosus 3 oxoacyl acyl carrier protein synthase 0.0195 0.127 0.1613
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0011 0.0009 0.0012
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0027 0.0119 0.0151
Schistosoma mansoni alcohol dehydrogenase 0.0048 0.0267 0.0339
Onchocerca volvulus 0.0726 0.4897 0.5149
Schistosoma mansoni hypothetical protein 0.0624 0.4203 0.5339
Mycobacterium tuberculosis Possible dehydrogenase 0.0048 0.0267 0.0283
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0045 0.0247 0.0275
Trypanosoma brucei acyl transferase-like protein 0.0049 0.0272 0.2069
Trypanosoma cruzi cysteine peptidase, putative 0.0055 0.0316 0.2433
Loa Loa (eye worm) hypothetical protein 0.1305 0.8856 1
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0753 0.5083 0.6437
Trichomonas vaginalis alpha-glucosidase, putative 0.0011 0.0012 0.0054
Mycobacterium tuberculosis Probable NADPH quinone oxidoreductase FadB4 (NADPH:quinone reductase) (zeta-crystallin) 0.0048 0.0267 0.0283
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0393 0.262 0.4682
Toxoplasma gondii cathepsin CPL 0.0015 0.0037 0.0034
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0825 0.5576 0.6981
Trypanosoma cruzi oxidoreductase, putative 0.0048 0.0267 0.2043
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0018 0.0091
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0078 0.0473 0.0271
Trypanosoma cruzi cysteine peptidase, putative 0.0055 0.0316 0.2433
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0019 0.0065 0.0349
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0055 0.0316 0.2417
Brugia malayi acetyltransferase, GNAT family protein 0.0145 0.0928 0.0925
Trypanosoma cruzi cysteine peptidase, putative 0.0015 0.0037 0.0216
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0045 0.007
Brugia malayi intermediate filament protein 0.0045 0.0247 0.0244
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0138 0.1022
Schistosoma mansoni survival motor neuron protein 0.0042 0.0224 0.0284
Leishmania major zinc-binding dehydrogenase-like protein 0.0048 0.0267 0.1672
Brugia malayi acyl carrier protein, mitochondrial precursor, putative 0.0078 0.0473 0.047
Toxoplasma gondii acyl carrier protein ACP 0.0078 0.0473 0.082
Loa Loa (eye worm) intermediate filament protein 0.0045 0.0247 0.0275
Leishmania major cysteine peptidase A (CPA) 0.0015 0.0037 0.0161
Brugia malayi Glycosyl hydrolases family 31 protein 0.0011 0.0012 0.0008
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0204 0.136
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0705 0.4753 0.6037
Loa Loa (eye worm) hypothetical protein 0.0106 0.0665 0.0747
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0037 0.0191 0.0243
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0229 0.1557
Mycobacterium ulcerans polyketide synthase Pks13 0.1161 0.7872 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0015 0.0037 0.0046
Loa Loa (eye worm) hypothetical protein 0.0021 0.0081 0.0087
Schistosoma mansoni hypothetical protein 0.0027 0.0119 0.0151
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0037 0.0214
Brugia malayi isocitrate dehydrogenase 0.0016 0.0045 0.0041
Brugia malayi cytoplasmic intermediate filament protein 0.0024 0.0103 0.01
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0037 0.0191 0.0212
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0032 0.0157 0.0199
Onchocerca volvulus 0.0045 0.0247 0.0256
Schistosoma mansoni [ACP] S-malonyltransferase 0.0049 0.0272 0.0346
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0015 0.0037 0.0037
Entamoeba histolytica cysteine protease, putative 0.0015 0.0037 0.07
Mycobacterium tuberculosis Possible quinone oxidoreductase (NADPH:quinone oxidoreductase) (zeta-crystallin) 0.0048 0.0267 0.0283
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0078 0.0473 0.047
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0065 0.0062
Mycobacterium ulcerans polyketide synthase Pks9 0.0514 0.3448 0.4183
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0078 0.0473 0.0271
Leishmania major NADP-dependent alcohol dehydrogenase, putative 0.0048 0.0267 0.1672
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0037 0.0214
Mycobacterium ulcerans hypothetical protein 0.0078 0.0473 0.0271
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0625 0.4209 0.5183
Trypanosoma cruzi target of rapamycin kinase 3 0.0019 0.0065 0.0443
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0044 0.024 0.1811
Trypanosoma brucei glucosidase, putative 0.0029 0.0138 0.1003
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0019 0.0065 0.0443
Echinococcus granulosus mitochondrial trans 2 enoyl coenzyme A reductase 0.0048 0.0267 0.0339
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0048 0.0267 0.0263
Trichomonas vaginalis alpha-glucosidase, putative 0.0011 0.0012 0.0054
Mycobacterium leprae PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) 0.0244 0.1605 0.1759
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0032 0.0157 0.0199
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.005 0.0278 0.0274
Trypanosoma cruzi PAB1-binding protein , putative 0.0021 0.0077 0.0539
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0015 0.0037 0.0214
Mycobacterium tuberculosis Acyl carrier protein (ACP) MbtL 0.0078 0.0473 0.0547
Giardia lamblia Methyltransferase like 2 0.0234 0.1536 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0065 0.0401
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 0.0078 0.0473 0.0271
Onchocerca volvulus 0.0048 0.0267 0.0277
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0777 0.5246 0.6547
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0048 0.0267 0.2043
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0048 0.0267 0.0263
Loa Loa (eye worm) ctsf protein 0.0015 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0021 0.0081 0.0087
Onchocerca volvulus 0.0082 0.0496 0.0518
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0267 0.1762 0.2194
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0019 0.0065 0.0443
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0019 0.0065 0.0083
Echinococcus granulosus lamin dm0 0.0045 0.0247 0.0314
Brugia malayi Cathepsin L-like precursor 0.0015 0.0037 0.0033
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0032 0.0157 0.0153
Echinococcus multilocularis serine protein kinase ATM 0.0026 0.0113 0.0144
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0048 0.0267 0.5604
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0065 0.0401
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0027 0.0119 0.0151
Brugia malayi CXXC zinc finger family protein 0.0025 0.0108 0.0104
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0037 0.0214
Schistosoma mansoni hypothetical protein 0.0042 0.0224 0.0284
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0048 0.0267 0.2043
Leishmania major hypothetical protein, conserved 0.0021 0.0077 0.0428
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0019 0.0065 0.0083
Brugia malayi latrophilin 2 splice variant baaae 0.0057 0.0329 0.0325
Schistosoma mansoni cpg binding protein 0.0025 0.0108 0.0137
Trichomonas vaginalis CMGC family protein kinase 0.0044 0.024 0.154
Leishmania major cathepsin L-like protease 0.0055 0.0316 0.1994
Mycobacterium tuberculosis Meromycolate extension acyl carrier protein AcpM 0.0078 0.0473 0.0547
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0048 0.0267 0.2043
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks3 0.0119 0.0751 0.0902
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0029 0.0138 0.0877
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0726 0.4897 0.5528
Toxoplasma gondii type I fatty acid synthase, putative 0.0553 0.3716 0.6654
Mycobacterium tuberculosis S-nitrosomycothiol reductase MscR 0.0048 0.0267 0.0283
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0065 0.0401
Mycobacterium tuberculosis Hypothetical protein 0.0234 0.1536 0.1905
Plasmodium vivax malonyl CoA-acyl carrier protein transacylase precursor, putative 0.0049 0.0272 0.1911
Loa Loa (eye worm) hypothetical protein 0.0119 0.0751 0.0845
Mycobacterium tuberculosis Probable polyketide synthase Pks17 0.019 0.1234 0.1519
Brugia malayi AMP-binding enzyme family protein 0.0726 0.4897 0.4896
Brugia malayi Cathepsin L-like precursor 0.0015 0.0037 0.0033
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0115 0.0721 0.5551
Wolbachia endosymbiont of Brugia malayi ACP S-malonyltransferase 0.0049 0.0272 0.0053
Onchocerca volvulus 0.0048 0.0267 0.0277
Mycobacterium tuberculosis Probable alcohol dehydrogenase AdhA 0.0048 0.0267 0.0283
Echinococcus multilocularis lamin dm0 0.0045 0.0247 0.0314
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0065 0.0401
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative 0.0195 0.127 1
Leishmania major alpha glucosidase II subunit, putative 0.0029 0.0138 0.0828
Echinococcus granulosus GPCR family 2 0.0027 0.0119 0.0151
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0558 0.3751 0.4735
Trypanosoma brucei protein kinase, putative 0.0044 0.024 0.1811
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0019 0.0065 0.0349
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0037 0.0214
Leishmania major quinone oxidoreductase, putative 0.0048 0.0267 0.1672
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0037 0.0191 0.0243
Trichomonas vaginalis sucrase-isomaltase, putative 0.0029 0.0138 0.0877
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.0138 0.0877
Brugia malayi MAP kinase sur-1 0.0044 0.024 0.0236
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0011 0.0012 0.0177
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0138 0.1022
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0195 0.127 0.1319
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0009 0.0037
Echinococcus multilocularis cpg binding protein 0.0026 0.0117 0.0149
Schistosoma mansoni cpg binding protein 0.0026 0.0117 0.0149
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0044 0.024 0.0267
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0027 0.0119 0.0151
Plasmodium vivax hypothetical protein, conserved 0.0115 0.0721 0.5551
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0195 0.127 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0055 0.0316 0.2417
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0777 0.5246 0.6645
Echinococcus multilocularis cysteine protease 0.0015 0.0037 0.0046
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0078 0.0473 0.0547
Trypanosoma brucei oxidoreductase, putative 0.0048 0.0267 0.2027
Plasmodium vivax acyl carrier protein, putative 0.0078 0.0473 0.3542
Plasmodium vivax ataxin-2 like protein, putative 0.0021 0.0077 0.033
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0037 0.0214
Schistosoma mansoni fkbp-rapamycin associated protein 0.0011 0.0009 0.0012
Treponema pallidum acyl carrier protein 0.0078 0.0473 0.5
Trypanosoma cruzi Acyl carrier protein, mitochondrial, putative 0.0078 0.0473 0.3682
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0019 0.0065 0.0083
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0026 0.0113 0.0823
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0777 0.5246 0.6547
Brugia malayi Cathepsin L-like precursor 0.0015 0.0037 0.0033
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0229 0.038
Echinococcus granulosus acyl carrier protein mitochondrial 0.0078 0.0473 0.0601
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.0754 0.0847
Leishmania major nuclear receptor binding factor-like protein 0.0048 0.0267 0.1672
Schistosoma mansoni hypothetical protein 0.0027 0.0119 0.0151
Brugia malayi Cathepsin L-like precursor 0.0015 0.0037 0.0033
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0229 0.029
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0037 0.0214
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0055 0.0316 0.2417
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0048 0.0267 0.1717
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0026 0.0113 0.0803
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0055 0.0316 0.2417
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0044 0.024 0.1494
Loa Loa (eye worm) hypothetical protein 0.0045 0.0242 0.0269
Loa Loa (eye worm) cysteine protease 0.0015 0.0037 0.0037

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 5 uM Cytotoxicity against human A549 cells after 96 hrs by MTT assay ChEMBL. 16792409
IC50 (functional) > 5 uM Cytotoxicity against human A2780 cells after 96 hrs by MTT assay ChEMBL. 16792409
IC50 (functional) > 5 uM Cytotoxicity against human Bel7402 cells after 96 hrs by MTT assay ChEMBL. 16792409
IC50 (functional) > 5 uM Cytotoxicity against human BGC823 cells after 96 hrs by MTT assay ChEMBL. 16792409
IC50 (functional) > 5 uM Cytotoxicity against human HCT8 cells after 96 hrs by MTT assay ChEMBL. 16792409
IC50 (functional) > 5 uM Cytotoxicity against human MCF7 cells after 96 hrs by MTT assay ChEMBL. 16792409
IC50 (functional) > 5 uM Cytotoxicity against human WISH cells after 96 hrs by MTT assay ChEMBL. 16792409

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 16792409

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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