Detailed information for compound 994570

Basic information

Technical information
  • TDR Targets ID: 994570
  • Name: 4,7-dimethoxyphenanthren-2-ol
  • MW: 254.281 | Formula: C16H14O3
  • H donors: 1 H acceptors: 1 LogP: 4.01 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(O)cc2c1c1ccc(cc1cc2)OC
  • InChi: 1S/C16H14O3/c1-18-13-5-6-14-10(8-13)3-4-11-7-12(17)9-15(19-2)16(11)14/h3-9,17H,1-2H3
  • InChiKey: BLEJCVUXRRNLMA-UHFFFAOYSA-N  

Network

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Synonyms

  • 4,7-dimethoxy-2-phenanthrenol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0726 0.4897 0.5528
Schistosoma mansoni microtubule-associated protein tau 0.1162 0.7873 1
Mycobacterium tuberculosis Probable NADPH quinone oxidoreductase FadB4 (NADPH:quinone reductase) (zeta-crystallin) 0.0048 0.0267 0.0283
Mycobacterium ulcerans polyketide synthase 0.0777 0.5246 0.6547
Loa Loa (eye worm) ctsf protein 0.0015 0.0037 0.0037
Mycobacterium ulcerans short-chain dehydrogenase 0.0052 0.029 0.003
Loa Loa (eye worm) hypothetical protein 0.0021 0.0081 0.0087
Trypanosoma cruzi cysteine peptidase, putative 0.0055 0.0316 0.2433
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0032 0.0157 0.0999
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0037 0.0214
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0032 0.0157 0.0153
Schistosoma mansoni [ACP] S-malonyltransferase 0.0049 0.0272 0.0346
Echinococcus granulosus mitochondrial trans 2 enoyl coenzyme A reductase 0.0048 0.0267 0.0339
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.005 0.0278 0.0014
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0032 0.0157 0.0999
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0065 0.0401
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0037 0.0214
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0204 0.136
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0044 0.024 0.1494
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0015 0.0037 0.0046
Trypanosoma cruzi cruzipain precursor, putative 0.0055 0.0316 0.2433
Brugia malayi Glycosyl hydrolases family 31 protein 0.0029 0.0138 0.0135
Leishmania major nuclear receptor binding factor-like protein 0.0048 0.0267 0.1672
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0044 0.024 0.1811
Onchocerca volvulus 0.0015 0.0037 0.0035
Plasmodium vivax acyl carrier protein, putative 0.0078 0.0473 0.3542
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0065 0.0069
Toxoplasma gondii 3-oxoacyl-acyl-carrier protein synthase I/II, putative 0.0195 0.127 0.2253
Echinococcus multilocularis serine protein kinase ATM 0.0026 0.0113 0.0144
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0037 0.0191 0.0243
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0037 0.0214
Schistosoma mansoni cpg binding protein 0.0026 0.0117 0.0149
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0157 0.0999
Wolbachia endosymbiont of Brugia malayi acyl carrier protein 0.0078 0.0473 0.2059
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0027 0.0119 0.0151
Mycobacterium tuberculosis Conserved hypothetical protein 0.0078 0.0473 0.0547
Brugia malayi N-terminal motif family protein 0.0181 0.1172 0.1168
Brugia malayi Glycosyl hydrolases family 31 protein 0.0133 0.0843 0.084
Echinococcus granulosus mitogen activated protein kinase 0.0044 0.024 0.0305
Schistosoma mansoni cathepsin F (C01 family) 0.0015 0.0037 0.0046
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0048 0.0267 0.2043
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0229 0.1557
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0055 0.0316 0.2417
Leishmania major cysteine peptidase A (CPA) 0.0015 0.0037 0.0161
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0045 0.0284
Loa Loa (eye worm) hypothetical protein 0.0032 0.0157 0.0173
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0504 0.3381 0.6051
Mycobacterium tuberculosis Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) 0.0048 0.0267 0.0283
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0029 0.0138 0.2863
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0065 0.0401
Schistosoma mansoni zinc binding dehydrogenase 0.0048 0.0267 0.0339
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0133 0.0843 0.0948
Chlamydia trachomatis 3-oxoacyl-ACP synthase 0.0195 0.127 1
Onchocerca volvulus Fatty acid synthase homolog 0.1401 0.9507 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0037 0.0191 0.0212
Onchocerca volvulus 0.0015 0.0037 0.0035
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0078 0.0473 0.0547
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0514 0.3448 0.4183
Onchocerca volvulus Cathepsin L homolog 0.0015 0.0037 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0065 0.0401
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0037 0.0191 0.0188
Brugia malayi Phosphopantetheine attachment site family protein 0.0078 0.0473 0.047
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0037 0.0214
Leishmania major cathepsin L-like protease 0.0015 0.0037 0.0161
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0229 0.038
Trichomonas vaginalis alpha-glucosidase, putative 0.0011 0.0012 0.0054
Mycobacterium ulcerans thioesterase TesA 0.0648 0.4361 0.5384
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.0138 0.0877
Echinococcus multilocularis Malonyl coenzyme A acyl carrier protein transacylase 0.0049 0.0272 0.0346
Schistosoma mansoni acyl carrier protein 0.0078 0.0473 0.0601
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0037 0.0214
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0048 0.0267 0.1717
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0045 0.007
Leishmania major cathepsin L-like protease 0.0055 0.0316 0.1994
Trypanosoma brucei beta-ketoacyl-ACP synthase 0.0195 0.127 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0027 0.0119 0.0115
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0037 0.0214
Toxoplasma gondii target of rapamycin (TOR), putative 0.0019 0.0065 0.0086
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0045 0.0218
Mycobacterium ulcerans polyketide synthase MbtC 0.0195 0.127 0.1319
Schistosoma mansoni hypothetical protein 0.0027 0.0119 0.0151
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0119 0.0751 0.0902
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0019 0.0065 0.0349
Echinococcus granulosus survival motor neuron protein 1 0.0206 0.1341 0.1704
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0777 0.5246 0.6547
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0055 0.0316 0.2417
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0019 0.0065 0.1309
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0009 0.0037
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0032 0.0157 0.0199
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0065 0.0401
Trypanosoma cruzi cysteine peptidase, putative 0.0055 0.0316 0.2433
Echinococcus multilocularis cysteine protease 0.0015 0.0037 0.0046
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0119 0.0751 0.0902
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0065 0.0401
Schistosoma mansoni hypothetical protein 0.0356 0.2366 0.3006
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0037 0.0191 0.0243
Echinococcus multilocularis mitogen activated protein kinase 0.0044 0.024 0.0305
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0037 0.0191 0.0243
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0267 0.1762 0.2194
Echinococcus granulosus cpg binding protein 0.0026 0.0117 0.0149
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0037
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0011 0.0012 0.0054
Trypanosoma cruzi Acyl carrier protein, mitochondrial, putative 0.0078 0.0473 0.3682
Loa Loa (eye worm) acyl carrier protein 0.0078 0.0473 0.0531
Trypanosoma cruzi oxidoreductase, putative 0.0048 0.0267 0.2043
Trypanosoma cruzi major cysteine proteinase, putative 0.0044 0.0235 0.179
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 0.0078 0.0473 0.0271
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0032 0.0157 0.0199
Brugia malayi Glycosyl hydrolases family 31 protein 0.0011 0.0012 0.0008
Leishmania major NADP-dependent alcohol dehydrogenase, putative 0.0048 0.0267 0.1672
Loa Loa (eye worm) alcohol dehydrogenase class III 0.0048 0.0267 0.0297
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0084 0.051 0.0507
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0195 0.127 0.1266
Trichomonas vaginalis CMGC family protein kinase 0.0044 0.024 0.154
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0037 0.0191 0.0243
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0055 0.0316 0.2417
Onchocerca volvulus 0.0077 0.0461 0.0481
Brugia malayi acyl carrier protein, mitochondrial precursor, putative 0.0078 0.0473 0.047
Leishmania major phosphatidylinositol kinase related protein, putative 0.0019 0.0065 0.035
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0032 0.0157 0.3259
Entamoeba histolytica cysteine proteinase, putative 0.0015 0.0037 0.07
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0027 0.0119 0.0151
Mycobacterium ulcerans polyketide synthase 0.0825 0.5576 0.6981
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0048 0.0267 0.5604
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0026 0.0113 0.0803
Loa Loa (eye worm) hypothetical protein 0.0021 0.0077 0.0083
Mycobacterium tuberculosis Possible dehydrogenase 0.0048 0.0267 0.0283
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0011 0.0012 0.0021
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative 0.0195 0.127 1
Schistosoma mansoni 3-oxoacyl-[ACP] synthase 0.0195 0.127 0.1613
Mycobacterium tuberculosis Probable polyketide synthase Pks17 0.019 0.1234 0.1519
Loa Loa (eye worm) acyl carrier protein 0.0357 0.2378 0.2683
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0045 0.0057
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0037 0.0214
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0825 0.5576 0.7067
Brugia malayi Cathepsin L-like precursor 0.0015 0.0037 0.0033
Trypanosoma brucei acyl transferase-like protein 0.0049 0.0272 0.2069
Echinococcus multilocularis geminin 0.0624 0.4203 0.5339
Schistosoma mansoni hypothetical protein 0.0027 0.0119 0.0151
Schistosoma mansoni lamin 0.0045 0.0247 0.0314
Onchocerca volvulus 0.0025 0.0108 0.0109
Echinococcus multilocularis dnaJ subfamily B 0.0356 0.2366 0.3006
Leishmania major hypothetical protein, conserved 0.0021 0.0077 0.0428
Echinococcus granulosus AMP dependent ligase 0.0078 0.0473 0.0601
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0065 0.0401
Echinococcus multilocularis AMP dependent ligase 0.0078 0.0473 0.0601
Echinococcus granulosus geminin 0.0624 0.4203 0.5339
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0009 0.0037
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0032 0.0157 0.1169
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0018 0.0091
Loa Loa (eye worm) hypothetical protein 0.0048 0.0267 0.0297
Schistosoma mansoni hypothetical protein 0.0078 0.0473 0.0601
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0055 0.0316 0.2417
Onchocerca volvulus Putative alcohol dehydrogenase 0.0048 0.0267 0.0277
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0229 0.1467
Mycobacterium ulcerans hypothetical protein 0.0078 0.0473 0.0271
Brugia malayi Calcitonin receptor-like protein seb-1 0.0084 0.051 0.0507
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0015 0.0037 0.0214
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0195 0.127 0.1319
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0204 0.0946
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0138 0.1022
Loa Loa (eye worm) hypothetical protein 0.0119 0.0751 0.0845
Onchocerca volvulus 0.0015 0.0037 0.0035
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0037 0.0214
Toxoplasma gondii acyl carrier protein ACP 0.0078 0.0473 0.082
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0044 0.024 0.1828
Brugia malayi CXXC zinc finger family protein 0.0025 0.0108 0.0104
Entamoeba histolytica cysteine proteinase, putative 0.0015 0.0037 0.07
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0048 0.0267 0.0263
Plasmodium falciparum ataxin-2 like protein, putative 0.0021 0.0077 0.033
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0011 0.0009 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0065 0.0401
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0037 0.0191 0.0243
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0825 0.5576 0.6981
Brugia malayi Papain family cysteine protease containing protein 0.0015 0.0037 0.0033
Echinococcus multilocularis mitochondrial trans 2 enoyl coenzyme A reductase 0.0048 0.0267 0.0339
Mycobacterium tuberculosis Possible dehydrogenase 0.0048 0.0267 0.0283
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0195 0.127 0.1319
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0037 0.0214
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0019 0.0065 0.0443
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0019 0.0065 0.0083
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0065 0.0401
Echinococcus granulosus 3 oxoacyl acyl carrier protein synthase 0.0195 0.127 0.1613
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0648 0.4361 0.5384
Schistosoma mansoni [ACP] S-malonyltransferase 0.0049 0.0272 0.0346
Leishmania major oxidoreductase, putative 0.0048 0.0267 0.1672
Mycobacterium tuberculosis Probable NADP-dependent alcohol dehydrogenase AdhC 0.0048 0.0267 0.0283
Brugia malayi Alcohol dehydrogenase class III 0.0048 0.0267 0.0263
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.0078 0.0473 0.0271
Loa Loa (eye worm) hypothetical protein 0.0022 0.0088 0.0096
Trichomonas vaginalis alpha-glucosidase, putative 0.0011 0.0012 0.0054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0037 0.0214
Mycobacterium leprae conserved hypothetical protein 0.0078 0.0473 0.0271
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0019 0.0065 0.0423
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0078 0.0473 0.0547
Mycobacterium leprae PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) 0.0244 0.1605 0.1759
Chlamydia trachomatis acyl carrier protein 0.0078 0.0473 0.2016
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.005 0.0278 0.0274
Loa Loa (eye worm) fibroinase 0.0015 0.0037 0.0037
Schistosoma mansoni alpha-glucosidase 0.0114 0.0717 0.0911
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0726 0.4897 0.62
Loa Loa (eye worm) acetyltransferase 0.0145 0.0928 0.1044
Echinococcus multilocularis 3 oxoacyl (acyl carrier protein) synthase 0.0195 0.127 0.1613
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0045 0.0057
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0635 0.4279 0.5409
Entamoeba histolytica cysteine protease, putative 0.0015 0.0037 0.07
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0019 0.0065 0.0083
Loa Loa (eye worm) hypothetical protein 0.0048 0.0267 0.0297
Brugia malayi Cathepsin L-like precursor 0.0015 0.0037 0.0033
Schistosoma mansoni hypothetical protein 0.0624 0.4203 0.5339
Echinococcus multilocularis NADH dehydrogenase 0.0078 0.0473 0.0601
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0027 0.0119 0.0151
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0065 0.0401
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0065 0.0401
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0012 0.0018 0.0044
Brugia malayi MH2 domain containing protein 0.0119 0.0754 0.075
Echinococcus multilocularis cpg binding protein 0.0026 0.0117 0.0149
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0019 0.0065 0.0423
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0029 0.0138 0.0877
Echinococcus granulosus ubiquitin specific protease 41 0.0032 0.0157 0.0199
Schistosoma mansoni cpg binding protein 0.0025 0.0108 0.0137
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.005 0.0278 0.0353
Mycobacterium tuberculosis Probable alcohol dehydrogenase AdhA 0.0048 0.0267 0.0283
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0514 0.3448 0.4183
Brugia malayi Cathepsin L-like precursor 0.0015 0.0037 0.0033
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0045 0.0264
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0055 0.0316 0.2417
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0558 0.3751 0.4735
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0113 0.0713
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0229 0.029
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0055 0.0316 0.2417
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0048 0.0267 0.2043
Brugia malayi AMP-binding enzyme family protein 0.0726 0.4897 0.4896
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0065 0.0401
Mycobacterium ulcerans acyl carrier protein 0.0078 0.0473 0.0271
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0032 0.0157 0.0622
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0011 0.0012 0.0054
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0011 0.0012 0.0177
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0019 0.0065 0.0423
Mycobacterium ulcerans malonyl CoA-acyl carrier protein transacylase FabD 0.0049 0.0272 0.0007
Brugia malayi latrophilin 2 splice variant baaae 0.0057 0.0329 0.0325
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0037 0.0214
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0019 0.0065 0.0083
Onchocerca volvulus 0.0015 0.0037 0.0035
Echinococcus granulosus serine protein kinase ATM 0.0026 0.0113 0.0144
Mycobacterium tuberculosis S-nitrosomycothiol reductase MscR 0.0048 0.0267 0.0283
Trichomonas vaginalis alpha-glucosidase, putative 0.0011 0.0012 0.0054
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0044 0.024 0.04
Mycobacterium ulcerans polyketide synthase Pks13 0.1161 0.7872 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0037 0.0214
Onchocerca volvulus 0.0042 0.0224 0.0231
Loa Loa (eye worm) hypothetical protein 0.0021 0.0081 0.0087
Trypanosoma cruzi acyl transferase-like protein 0.0049 0.0272 0.2086
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0011 0.0009 0.0012
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0314 0.2084 0.2605
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0037 0.0191 0.0243
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0011 0.0012 0.0021
Schistosoma mansoni survival motor neuron protein 0.0042 0.0224 0.0284
Trichomonas vaginalis CMGC family protein kinase 0.0044 0.024 0.154
Toxoplasma gondii Zn-containing alcohol dehydrogenase 0.0048 0.0267 0.0449
Echinococcus granulosus mitogen activated protein kinase 3 0.0044 0.024 0.0305
Leishmania major zinc binding dehydrogenase-like protein 0.0048 0.0267 0.1672
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0045 0.0264
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0065 0.0401
Loa Loa (eye worm) hypothetical protein 0.0012 0.0018 0.0016
Mycobacterium tuberculosis Probable acyl carrier protein AcpA (ACP) 0.0078 0.0473 0.0547
Brugia malayi Intermediate filament tail domain containing protein 0.0045 0.0247 0.0244
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0032 0.0157 0.0199
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0048 0.0267 0.5604
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0015 0.0037 0.0214
Echinococcus granulosus histone acetyltransferase KAT2B 0.0141 0.09 0.1144
Echinococcus multilocularis neutral alpha glucosidase AB 0.0029 0.0138 0.0176
Entamoeba histolytica protein kinase rad3, putative 0.0011 0.0009 0.012
Echinococcus granulosus microtubule associated protein 2 0.1162 0.7873 1
Leishmania major cathepsin L-like protease 0.0015 0.0037 0.0161
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0825 0.5576 0.7067
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0195 0.127 1
Mycobacterium ulcerans Type I modular polyketide synthase 0.0777 0.5246 0.6547
Mycobacterium leprae PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 0.0119 0.0751 0.0637
Toxoplasma gondii type I fatty acid synthase 0.0119 0.0751 0.132
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0006
Leishmania major zinc-binding dehydrogenase-like protein 0.0048 0.0267 0.1672
Echinococcus granulosus acyl carrier protein mitochondrial 0.0078 0.0473 0.0601
Onchocerca volvulus 0.0048 0.0267 0.0277
Mycobacterium ulcerans Type I modular polyketide synthase 0.0777 0.5246 0.6547
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0037 0.0214
Schistosoma mansoni hypothetical protein 0.0057 0.0329 0.0418
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0078 0.0473 0.0271
Loa Loa (eye worm) hypothetical protein 0.0027 0.0119 0.013
Brugia malayi hypothetical protein 0.0021 0.0077 0.0074
Trypanosoma cruzi target of rapamycin kinase 3 0.0019 0.0065 0.0443
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0065 0.0401
Loa Loa (eye worm) hypothetical protein 0.0045 0.0247 0.0275
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0065 0.0401
Plasmodium vivax malonyl CoA-acyl carrier protein transacylase precursor, putative 0.0049 0.0272 0.1911
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0777 0.5246 0.5244
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0065 0.0401
Trypanosoma cruzi PAB1-binding protein , putative 0.0021 0.0077 0.0539
Loa Loa (eye worm) hypothetical protein 0.0106 0.0665 0.0747
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0442 0.2955 0.3718
Plasmodium falciparum acyl carrier protein 0.0078 0.0473 0.3542
Loa Loa (eye worm) hypothetical protein 0.0057 0.0329 0.0367
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0055 0.0316 0.2417
Echinococcus granulosus GPCR family 2 0.0027 0.0119 0.0151
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0045 0.0057
Onchocerca volvulus Huntingtin homolog 0.0106 0.0665 0.0696
Schistosoma mansoni alpha-glucosidase 0.0114 0.0717 0.0911
Toxoplasma gondii type I fatty acid synthase, putative 0.0825 0.5576 1
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0138 0.1022
Brugia malayi Cathepsin L-like precursor 0.0015 0.0037 0.0033
Brugia malayi ADP-specific Phosphofructokinase/Glucokinase conserved region family protein 0.0049 0.0272 0.0269
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0044 0.024 0.1494
Entamoeba histolytica acyl-CoA synthetase, putative 0.0078 0.0473 1
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0045 0.0041
Loa Loa (eye worm) hypothetical protein 0.0106 0.0665 0.0747
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0032 0.0157 0.1151
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0825 0.5576 0.6981
Loa Loa (eye worm) hypothetical protein 0.0084 0.051 0.0572
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0037 0.0214
Loa Loa (eye worm) CXXC zinc finger family protein 0.0025 0.0108 0.0117
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0145 0.0928 0.1179
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0029 0.0138 0.0877
Leishmania major cathepsin L-like protease 0.0015 0.0037 0.0161
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0037 0.0214
Loa Loa (eye worm) hypothetical protein 0.0048 0.0267 0.0297
Trypanosoma brucei oxidoreductase, putative 0.0048 0.0267 0.2027
Plasmodium vivax hypothetical protein, conserved 0.0115 0.0721 0.5551
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.005 0.0278 0.0353
Trichomonas vaginalis CMGC family protein kinase 0.0044 0.024 0.154
Schistosoma mansoni hypothetical protein 0.0027 0.0119 0.0151
Schistosoma mansoni methyltransferase-related 0.0234 0.1536 0.1952
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0037 0.0214
Loa Loa (eye worm) latrophilin receptor protein 2 0.0027 0.0119 0.013
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0044 0.024 0.1828
Leishmania major oxidoreductase-like protein 0.0048 0.0267 0.1672
Echinococcus granulosus dnaJ subfamily B 0.0356 0.2366 0.3006
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0078 0.0473 0.0271
Brugia malayi hypothetical protein 0.0206 0.1341 0.1338
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0065 0.0062
Loa Loa (eye worm) fatty acid synthase 0.0767 0.5176 0.5842
Trichomonas vaginalis maltase-glucoamylase, putative 0.0029 0.0138 0.0877
Loa Loa (eye worm) hypothetical protein 0.0119 0.0751 0.0845
Entamoeba histolytica NADP-dependent alcohol dehydrogenase 0.0048 0.0267 0.5604
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0015 0.0037 0.0046
Onchocerca volvulus Cathepsin L homolog 0.0015 0.0037 0.0035
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0078 0.0473 0.0547
Mycobacterium ulcerans thioesterase 0.0648 0.4361 0.5384
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0777 0.5246 0.6645
Mycobacterium ulcerans polyketide synthase MbtD 0.0239 0.1569 0.1713
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0032 0.0157 0.0199
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0019 0.0065 0.0349
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0029 0.0138 0.0217
Mycobacterium ulcerans fatty acid synthase Fas 0.0244 0.1605 0.1759
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0078 0.0473 0.0271
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0065 0.0401
Brugia malayi Cathepsin L-like precursor 0.0015 0.0037 0.0033
Loa Loa (eye worm) hypothetical protein 0.0048 0.0267 0.0297
Entamoeba histolytica acyl-CoA synthetase, putative 0.0078 0.0473 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0065 0.0401
Trypanosoma cruzi cysteine peptidase, putative 0.0015 0.0037 0.0216
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0078 0.0473 0.0271
Schistosoma mansoni fkbp-rapamycin associated protein 0.0011 0.0009 0.0012
Plasmodium falciparum ataxin-2 like protein, putative 0.0021 0.0077 0.033
Trypanosoma cruzi acyl transferase-like protein, putative 0.0049 0.0272 0.2086
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0825 0.5576 0.7067
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks4 0.0119 0.0751 0.0902
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0065 0.0401
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0018 0.0091
Leishmania major cathepsin L-like protease 0.0055 0.0316 0.1994
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0022 0.0087 0.011
Mycobacterium tuberculosis Acyl carrier protein (ACP) MbtL 0.0078 0.0473 0.0547
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0032 0.0157 0.0199
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0181 0.1172 0.1229
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0065 0.0069
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0037 0.0214
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0045 0.0057
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0044 0.024 0.0267
Leishmania major hypothetical protein, conserved 0.0234 0.1536 1
Mycobacterium tuberculosis Probable quinone reductase Qor (NADPH:quinone reductase) (zeta-crystallin homolog protein) 0.0048 0.0267 0.0283
Toxoplasma gondii cathepsin CPL 0.0015 0.0037 0.0034
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0048 0.0267 0.0263
Echinococcus granulosus Malonyl coenzyme A acyl carrier protein transacylase 0.0049 0.0272 0.0346
Onchocerca volvulus 0.0015 0.0037 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0065 0.0401
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0045 0.007
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0195 0.127 1
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0019 0.0065 0.0083
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0009 0.0037
Brugia malayi hypothetical protein 0.0106 0.0665 0.0661
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0032 0.0157 0.0199
Onchocerca volvulus 0.0015 0.0037 0.0035
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0777 0.5246 0.6547
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks3 0.0119 0.0751 0.0902
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0044 0.024 0.1828
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0019 0.0065 0.0423
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0048 0.0267 0.1717
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.1161 0.7872 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0065 0.0401
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0009 0.0037
Giardia lamblia Kinase, CMGC MAPK 0.0044 0.024 0.1186
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0019 0.0065 0.0349
Loa Loa (eye worm) hypothetical protein 0.0045 0.0242 0.0269
Loa Loa (eye worm) hypothetical protein 0.0022 0.0087 0.0094
Mycobacterium tuberculosis Probable alcohol dehydrogenase Adh 0.0048 0.0267 0.0283
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0825 0.5576 0.6981
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0065 0.0401
Echinococcus multilocularis ubiquitin specific protease 41 0.0032 0.0157 0.0199
Schistosoma mansoni alcohol dehydrogenase 0.0048 0.0267 0.0339
Leishmania major cathepsin L-like protease 0.0055 0.0316 0.1994
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.0754 0.0847
Mycobacterium leprae Probable polyketide synthase Pks1 0.0825 0.5576 0.6981
Echinococcus granulosus cathepsin l1 0.0015 0.0037 0.0046
Plasmodium falciparum malonyl CoA-acyl carrier protein transacylase 0.0049 0.0272 0.1911
Mycobacterium tuberculosis Polyketide synthase Pks13 0.1161 0.7872 1
Mycobacterium ulcerans Type I modular polyketide synthase 0.0777 0.5246 0.6547
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0048 0.0267 0.2043
Echinococcus granulosus intermediate filament protein 0.0045 0.0247 0.0314
Loa Loa (eye worm) hypothetical protein 0.0206 0.1341 0.1511
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0048 0.0267 0.2043
Echinococcus granulosus cathepsin l1 0.001 0.0004 0.0005
Toxoplasma gondii LsmAD domain-containing protein 0.0021 0.0077 0.0107
Onchocerca volvulus Acyl carrier protein, mitochondrial homolog 0.0078 0.0473 0.0494
Mycobacterium tuberculosis Conserved protein 0.0234 0.1536 0.1905
Brugia malayi Cathepsin L-like precursor 0.0015 0.0037 0.0033
Echinococcus granulosus neutral alpha glucosidase AB 0.0029 0.0138 0.0176
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0032 0.0157 0.1169
Leishmania major alpha glucosidase II subunit, putative 0.0029 0.0138 0.0828
Loa Loa (eye worm) intermediate filament protein 0.0045 0.0247 0.0275
Echinococcus multilocularis cathepsin L cysteine protease 0.0015 0.0037 0.0046
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.0138 0.0877
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0045 0.0047
Entamoeba histolytica hypothetical protein 0.0026 0.0113 0.2328
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0026 0.0113 0.0823
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0777 0.5246 0.6645
Echinococcus multilocularis lysosomal alpha glucosidase 0.0133 0.0843 0.1071
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0055 0.0316 0.2417
Mycobacterium ulcerans polyketide synthase Pks9 0.0514 0.3448 0.4183
Onchocerca volvulus 0.1353 0.9178 0.9653
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0037 0.0214
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0204 0.4271
Trichomonas vaginalis CMGC family protein kinase 0.0044 0.024 0.154
Loa Loa (eye worm) hypothetical protein 0.0435 0.2912 0.3285
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0055 0.0316 0.2417
Toxoplasma gondii acyl transferase domain-containing protein 0.0049 0.0272 0.0458
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0019 0.0065 0.0083
Echinococcus multilocularis lamin dm0 0.0045 0.0247 0.0314
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0044 0.024 0.1828
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0009 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0009 0.0037
Echinococcus granulosus NADH dehydrogenase 0.0078 0.0473 0.0601
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0048 0.0267 0.2043
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0393 0.262 0.4682
Echinococcus granulosus lamin dm0 0.0045 0.0247 0.0314
Giardia lamblia Methyltransferase like 2 0.0234 0.1536 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.0019 0.0065 0.0349
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0239 0.1569 0.1947
Trichomonas vaginalis alpha-glucosidase, putative 0.0011 0.0012 0.0054
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0037 0.0191 0.0243
Plasmodium vivax ataxin-2 like protein, putative 0.0021 0.0077 0.033
Loa Loa (eye worm) hypothetical protein 0.0011 0.0012 0.0009
Trypanosoma brucei Trans-2-enoyl-ACP reductase 2, putative 0.0048 0.0267 0.2027
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0047 0.0255 0.0284
Schistosoma mansoni hypothetical protein 0.0027 0.0119 0.0151
Onchocerca volvulus 0.0015 0.0037 0.0035
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0055 0.0316 0.2417
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0029 0.0138 0.2863
Schistosoma mansoni alpha glucosidase 0.0029 0.0138 0.0176
Loa Loa (eye worm) hypothetical protein 0.0049 0.0272 0.0303
Mycobacterium ulcerans acyl-CoA synthetase 0.0078 0.0473 0.0271
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0019 0.0065 0.0443
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0048 0.0267 0.0263
Echinococcus multilocularis Acyl carrier protein, mitochondrial 0.0078 0.0473 0.0601
Onchocerca volvulus 0.0726 0.4897 0.5149
Brugia malayi AMP-binding enzyme family protein 0.0239 0.1569 0.1566
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0026 0.0113 0.0109
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0027 0.0119 0.0151
Leishmania major beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative 0.0195 0.127 0.825
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0777 0.5246 0.6645
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0011 0.0009 0.012
Trypanosoma brucei protein kinase, putative 0.0044 0.024 0.1811
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0705 0.4753 0.6037
Schistosoma mansoni [ACP] S-malonyltransferase 0.0049 0.0272 0.0346
Onchocerca volvulus 0.0048 0.0267 0.0277
Schistosoma mansoni cpg binding protein 0.0026 0.0117 0.0149
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0065 0.0401
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0037 0.0214
Echinococcus multilocularis microtubule associated protein 2 0.1162 0.7873 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0011 0.0012 0.0054
Leishmania major acyl carrier protein, putative 0.0078 0.0473 0.3026
Mycobacterium tuberculosis Hypothetical protein 0.0234 0.1536 0.1905
Echinococcus multilocularis cathepsin L cysteine protease 0.0015 0.0037 0.0046
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0029 0.0138 0.0152
Trypanosoma cruzi oxidoreductase, putative 0.0048 0.0267 0.2043
Mycobacterium tuberculosis Probable thioesterase TesA 0.0648 0.4361 0.5514
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0065 0.0401
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0032 0.0157 0.0949
Mycobacterium leprae Polyketide synthase Pks13 0.1161 0.7872 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0229 0.1467
Treponema pallidum acyl carrier protein 0.0078 0.0473 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0065 0.0401
Trypanosoma cruzi cysteine peptidase, putative 0.0055 0.0316 0.2433
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0625 0.4209 0.5183
Toxoplasma gondii quinone oxidoreductase, putative 0.0048 0.0267 0.0449
Mycobacterium tuberculosis Possible oxidoreductase FadB5 0.0048 0.0267 0.0283
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.0754 0.0847
Trypanosoma brucei glucosidase, putative 0.0029 0.0138 0.1003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0055 0.0316 0.2417
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0115 0.0721 0.5551
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0037 0.0214
Schistosoma mansoni cathepsin F (C01 family) 0.001 0.0004 0.0005
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0026 0.0113 0.0144
Plasmodium falciparum 3-oxoacyl-acyl-carrier protein synthase I/II 0.0195 0.127 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0037 0.0214
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0753 0.5083 0.6437
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0037 0.0214
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0045 0.005
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0045 0.0057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0009 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0234 0.1536 1
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0195 0.127 1
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0019 0.0065 0.0083
Echinococcus granulosus cathepsin L cysteine proteinase 0.0015 0.0037 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0065 0.0401
Trichomonas vaginalis sucrase-isomaltase, putative 0.0029 0.0138 0.0877
Brugia malayi MAP kinase sur-1 0.0044 0.024 0.0236
Brugia malayi isocitrate dehydrogenase 0.0016 0.0045 0.0041
Onchocerca volvulus 0.0045 0.0247 0.0256
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0053 0.0299 0.038
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.024 0.0305
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0015 0.0037 0.0037
Brugia malayi cytoplasmic intermediate filament protein 0.0024 0.0103 0.01
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0048 0.0267 0.1717
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0777 0.5246 0.6547
Schistosoma mansoni hypothetical protein 0.0042 0.0224 0.0284
Echinococcus multilocularis cysteine protease 0.0015 0.0037 0.0046
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0045 0.0057
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0019 0.0065 0.0443
Leishmania major cathepsin L-like protease 0.0015 0.0037 0.0161
Echinococcus granulosus lamin 0.0045 0.0247 0.0314
Echinococcus multilocularis lamin 0.0045 0.0247 0.0314
Trypanosoma cruzi oxidoreductase, putative 0.0048 0.0267 0.2043
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0625 0.4209 0.5183
Onchocerca volvulus 0.0082 0.0496 0.0518
Leishmania major cathepsin L-like protease 0.0015 0.0037 0.0161
Echinococcus multilocularis musashi 0.0045 0.0247 0.0314
Schistosoma mansoni cathepsin F (C01 family) 0.0015 0.0037 0.0046
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.005 0.0278 0.1744
Trypanosoma brucei Acyl carrier protein, mitochondrial 0.0078 0.0473 0.3668
Loa Loa (eye worm) phosphopantetheine attachment site family protein 0.0078 0.0473 0.0531
Schistosoma mansoni hypothetical protein 0.0624 0.4203 0.5339
Trypanosoma brucei oxidoreductase, putative 0.0048 0.0267 0.2027
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0084 0.051 0.0572
Loa Loa (eye worm) beta-ketoacyl synthase domain-containing protein 0.0195 0.127 0.143
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0625 0.4209 0.5183
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0065 0.0401
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0019 0.0065 0.0349
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0078 0.0473 0.0271
Loa Loa (eye worm) hypothetical protein 0.1305 0.8856 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0048 0.0267 0.0283
Brugia malayi Latrophilin receptor protein 2 0.0027 0.0119 0.0115
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0019 0.0065 0.1309
Loa Loa (eye worm) hypothetical protein 0.0181 0.1172 0.1319
Echinococcus multilocularis GPCR, family 2 0.0027 0.0119 0.0151
Schistosoma mansoni lamin 0.0045 0.0247 0.0314
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.005 0.0278 0.0297
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.0088 0.0627
Schistosoma mansoni intermediate filament proteins 0.0045 0.0247 0.0314
Brugia malayi acetyltransferase, GNAT family protein 0.0145 0.0928 0.0925
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0019 0.0065 0.0443
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0078 0.0473 0.047
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.0138 0.0877
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0078 0.0473 0.0547
Onchocerca volvulus 0.0045 0.0247 0.0256
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0042 0.0224 0.022
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0753 0.5083 0.6437
Brugia malayi Methyltransferase-like protein 4 0.0234 0.1536 0.1533
Echinococcus granulosus lysosomal alpha glucosidase 0.0133 0.0843 0.1071
Echinococcus multilocularis mitogen activated protein kinase 3 0.0044 0.024 0.0305
Mycobacterium ulcerans acyl carrier protein 0.0078 0.0473 0.0271
Brugia malayi intermediate filament protein 0.0045 0.0247 0.0244
Echinococcus multilocularis survival motor neuron protein 1 0.0206 0.1341 0.1704
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0045 0.0057
Brugia malayi hypothetical protein 0.0013 0.0028 0.0024
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.0138 0.0877
Mycobacterium tuberculosis Possible quinone oxidoreductase (NADPH:quinone oxidoreductase) (zeta-crystallin) 0.0048 0.0267 0.0283
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.0138 0.0877
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0244 0.1605 0.1993
Trichomonas vaginalis maltase-glucoamylase, putative 0.0011 0.0012 0.0054
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0019 0.0065 0.0423
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.005 0.0278 0.0353
Wolbachia endosymbiont of Brugia malayi ACP S-malonyltransferase 0.0049 0.0272 0.0053
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0065 0.0401
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0065 0.0401
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0011 0.0012 0.0009
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0045 0.005
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0051 0.0283 0.2172
Leishmania major quinone oxidoreductase, putative 0.0048 0.0267 0.1672
Loa Loa (eye worm) cysteine protease 0.0015 0.0037 0.0037
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0229 0.038
Trypanosoma brucei PAB1-binding protein , putative 0.0021 0.0077 0.0519
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0825 0.5576 0.6981
Onchocerca volvulus Cathepsin F homolog 0.0015 0.0037 0.0035
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0048 0.0267 0.2043
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0015 0.0037 0.0037
Toxoplasma gondii type I fatty acid synthase, putative 0.0553 0.3716 0.6654
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0145 0.0928 0.1179
Toxoplasma gondii histone lysine methyltransferase SET1 0.0051 0.0285 0.048
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.005 0.0278 0.0014
Leishmania major hypothetical protein, conserved 0.0049 0.0272 0.1707
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0019 0.0065 0.0445
Onchocerca volvulus Huntingtin homolog 0.0106 0.0665 0.0696
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0045 0.0247 0.0275
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0065 0.0062
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0078 0.0473 0.0271
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0078 0.0473 0.0547
Toxoplasma gondii FATC domain-containing protein 0.0026 0.0113 0.0172
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0024 0.0103 0.0112
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0011 0.0009 0.0006
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0045 0.0284
Trypanosoma cruzi PAB1-binding protein , putative 0.0021 0.0077 0.0539
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0065 0.0401
Leishmania major d-xylulose reductase, putative 0.0048 0.0267 0.1672
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0022 0.0087 0.011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0037 0.0214
Mycobacterium tuberculosis Meromycolate extension acyl carrier protein AcpM 0.0078 0.0473 0.0547
Echinococcus granulosus cathepsin l cysteine peptidase 0.0015 0.0037 0.0046
Echinococcus multilocularis lysosomal alpha glucosidase 0.0133 0.0843 0.1071

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 5 uM Cytotoxicity against human A549 cells after 96 hrs by MTT assay ChEMBL. 16792409
IC50 (functional) > 5 uM Cytotoxicity against human A2780 cells after 96 hrs by MTT assay ChEMBL. 16792409
IC50 (functional) > 5 uM Cytotoxicity against human Bel7402 cells after 96 hrs by MTT assay ChEMBL. 16792409
IC50 (functional) > 5 uM Cytotoxicity against human BGC823 cells after 96 hrs by MTT assay ChEMBL. 16792409
IC50 (functional) > 5 uM Cytotoxicity against human HCT8 cells after 96 hrs by MTT assay ChEMBL. 16792409
IC50 (functional) > 5 uM Cytotoxicity against human MCF7 cells after 96 hrs by MTT assay ChEMBL. 16792409
IC50 (functional) > 5 uM Cytotoxicity against human WISH cells after 96 hrs by MTT assay ChEMBL. 16792409

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 16792409

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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