Detailed view for GL50803_14566

Basic information

TDR Targets ID: 811653
Giardia lamblia, Dipeptidyl-peptidase I precursor
Source Database / ID:  GiardiaDB  

pI: 5.9714 | Length (AA): 541 | MW (Da): 59977 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00112   Papain family cysteine protease
PF08773   Cathepsin C exclusion domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0008234   cysteine-type peptidase activity  
GO:0006508   proteolysis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
14 489 3pdf (A) 1 438 33.00 0 1 0.786352 1.09
232 482 2c0y (A) 88 312 32.00 0 1 0.733056 -0.61
432 485 4yyw (A) 161 217 37.00 0.34 0.99 0.439215 0.22
432 470 2wbf (X) 761 803 49.00 0.00029 0.84 0.439189 0.95

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130494)

Species Accession Gene Product
Babesia bovis BBOV_I000540   preprocathepsin c precursor, putative
Babesia bovis BBOV_II000170   cathepsin C precursor, putative
Caenorhabditis elegans CELE_F36D3.9   Protein CPR-2
Cryptosporidium hominis Chro.40239   preprocathepsin c precursor
Cryptosporidium parvum cgd4_2110   preprocathepsin c precursor, putative
Dictyostelium discoideum DDB_G0292462   hypothetical protein
Giardia lamblia GL50803_14566   Dipeptidyl-peptidase I precursor
Homo sapiens ENSG00000109861   cathepsin C
Mus musculus ENSMUSG00000030560   cathepsin C
Neospora caninum NCLIV_041870   hypothetical protein
Plasmodium berghei PBANKA_1460700   dipeptidyl aminopeptidase 2
Plasmodium berghei PBANKA_0931300   dipeptidyl aminopeptidase 1, putative
Plasmodium falciparum PF3D7_1116700   dipeptidyl aminopeptidase 1
Plasmodium falciparum PF3D7_1247800   dipeptidyl aminopeptidase 2
Plasmodium knowlesi PKNH_1467500   dipeptidyl aminopeptidase 2, putative
Plasmodium knowlesi PKNH_0914400   dipeptidyl aminopeptidase 1, putative
Plasmodium vivax PVX_091465   dipeptidyl aminopeptidase 1, putative
Plasmodium vivax PVX_101280   dipeptidyl aminopeptidase 2, putative
Plasmodium yoelii PY02150   Homo sapiens P3ECSL-related
Plasmodium yoelii PY05365   cathepsin c precursor
Schistosoma japonicum Sjp_0207730   Cathepsin C precursor, putative
Schistosoma japonicum Sjp_0207740   ko:K01275 cathepsin C [EC3.4.14.1], putative
Schistosoma mansoni Smp_019030   dipeptidyl-peptidase I (C01 family)
Schmidtea mediterranea mk4.002926.00   Dipeptidyl peptidase 1
Schmidtea mediterranea mk4.002926.03   Dipeptidyl peptidase 1
Toxoplasma gondii TGME49_289620   cathepsin CPC1
Toxoplasma gondii TGME49_267490   preprocathepsin c precursor, putative
Theileria parva TP02_0883   cathepsin C, putative
Theileria parva TP03_0357   cathepsin C, putative
Trichomonas vaginalis TVAG_159150   Clan CA, family C1, cathepsin B-like cysteine peptidase

Essentiality

GL50803_14566 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_0931300 Plasmodium berghei Essential plasmo
PBANKA_1460700 Plasmodium berghei Dispensable plasmo
TGME49_289620 Toxoplasma gondii Probably non-essential sidik
TGME49_267490 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Mus musculus cathepsin C Compounds References
Homo sapiens cathepsin C Compounds References
Infectious bronchitis virus 3C-like protease Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Carica papaya Papain 345 aa 29.6% 280 aa Compounds References
Bos taurus Cathepsin L 334 aa 23.9% 272 aa Compounds References
Dermatophagoides pteronyssinus Peptidase 1 320 aa 24.2% 264 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0234 0.2802 1
0.0268 0.9201 0.9061
0.0282 0.595 0.8843
0.023 0.6946 0.6202
0.0134 0.3666 1
0.0247 0.2559 1
0.0117 0.3307 1
0.023 0.2803 1
3.5082 0.3846 1
0.2521 0.339 1
2.3572 0.3518 1
0.2209 0.7675 1
0.0496 0.7015 1
0.3172 0.983 0.5
0.0789 0.9465 1
0.0591 0.3201 1
0.0137 0.3398 1
0.0156 0.4995 0.4995
0.0817 0.2656 1
0.023 0.3502 1
0.012 0.4212 1
0.023 0.2679 1
0.023 0.2683 1
0.023 0.3232 0.6079
0.0218 0.5645 0.534
0.0243 0.4311 0.5
0.023 0.4868 1
0.023 0.7075 1
3.6841 0.3323 1
0.0327 0.3149 1
0.2521 0.339 1
0.0357 0.3132 0.7416
0.0633 0.3274 1
0.0399 0.5089 1
0.947 0.396 1
0.0238 0.2881 1
0.3172 0.983 0.5
0.0369 0.2826 1
0.0389 0.2741 1
0.0327 0.3149 1
0.0817 0.2656 1
3.2138 0.4305 1
0.0233 0.8001 1
0.2521 0.339 1
0.5569 0.9239 1
0.0143 0.3059 1
0.0584 0.7917 1
0.0241 0.2868 1
0.0131 0.4533 1
0.0275 0.3614 1
0.0143 0.7001 0.5
0.0235 0.8673 1
0.023 0.253 1
0.222 0.9209 1
0.0156 0.4995 0.4995
0.037 0.2801 0.5908
0.0235 0.2705 0.6351
0.0232 0.4179 1
0.0118 0.4166 1
0.0111 0.6672 0.5
0.382 0.3066 1
0.0244 0.6305 1
0.1076 0.4197 1
0.0438 0.4732 1
0.0514 0.3144 1
0.3015 0.7275 1
0.2521 0.339 1
0.1975 0.3004 1
0.0248 0.2682 0.8113
0.0833 0.8054 1
0.023 0.2679 1
0.0206 0.8835 1
0.023 0.2708 1
0.0245 0.5825 0.4997
0.4734 0.4615 0.5302
0.0657 0.3596 1
0.022 0.4811 1
0.0206 0.2617 1
0.0237 0.834 0.5
0.2809 0.3348 1
0.023 0.8254 1
0.1076 0.4197 1
0.1668 0.2538 1
2.9942 0.426 1
0.0248 0.2562 0.5
0.023 0.9247 0.5
0.023 0.2902 1
0.023 0.2558 1
0.0368 0.6181 1
0.2809 0.3348 1
0.1668 0.2538 1
0.012 0.4565 0.5
0.0254 0.6272 1
0.1668 0.2538 1
0.0788 0.9428 1
0.0237 0.2705 1
0.0255 0.3629 1
0.0205 0.2899 0.8749
0.021 0.5992 1
0.023 0.7056 1
0.0393 0.661 1
0.0417 0.3568 1
0.023 0.617 1
3.2346 0.5716 1
0.0611 0.4097 1
0.1482 0.356 1
0.0324 0.3378 1
0.0272 0.2927 1
0.0686 0.8155 1
0.0357 0.3132 0.7416
0.023 0.7733 1
0.0614 0.5286 1
0.0248 0.2854 1
0.2244 0.9224 1
0.0443 0.3302 0.5
0.0143 0.5587 1
0.1938 0.4513 1
0.025 0.5666 0.5526
0.0237 0.5293 1
0.0437 0.5008 1
0.1333 0.3433 1
0.1668 0.2538 1
0.1074 0.2867 1
0.0248 0.2562 0.5
0.023 0.6906 0.6906
0.023 0.8894 1
0.1975 0.3004 1
0.0437 0.5008 1
3.2338 0.3659 1
0.0341 0.3034 0.9249
2.9561 0.4648 1
0.0156 0.4995 0.4995
0.0462 0.6783 1
0.2536 0.8813 1
0.2521 0.339 1
0.3516 0.9749 1
0.0127 0.3283 1
0.947 0.396 1
0.0247 0.4345 0.5
0.038 0.408 1
0.031203 1 1
0.0143 0.4761 0.5
0.0156 0.4995 0.4995
0.023 0.512 1
0.0255 0.3398 1
0.0258 0.2962 1
0.0239 0.2887 1
0.0247 0.287 1
0.023 0.2565 1
0.3516 0.9749 1
0.3584 0.6489 1
0.03 0.3614 1
0.0601 0.3184 1
0.0244 0.255 1
0.0142 0.3589 1
0.023 0.2902 1
0.2209 0.7675 1
0.2809 0.3348 1
0.3584 0.6489 1
0.0143 0.3294 1
0.0427 0.3116 0.5
0.5569 0.9239 1
0.0303 0.3359 0.865
0.0235 0.2705 0.6351
0.0332 0.3236 1
0.0657 0.3596 1
0.00441349 0.95319 0
0.5388 0.5622 1
0.0441 0.2829 1
0.026 0.306 1
0.1074 0.2867 1
0.0143 0.7759 0.5
0.023 0.7784 1
0.3584 0.6489 1
3.2346 0.5716 1
0.0389 0.2741 1
0.2705 0.9985 1
0.023 0.5856 1
0.1076 0.4197 1
0.0417 0.5784 0.5
0.0236 0.2802 1
0.029 0.3429 1
0.0528 0.2548 0.8386
0.023 0.2558 1
0.0363 0.3734 1
0.4609 0.6331 1
0.2521 0.339 1
0.222 0.9209 1
0.023 0.9373 1
0.023 0.8402 1
0.2705 0.9985 1
0.0238 0.4279 1
0.023 0.2687 1
3.2346 0.5716 1
0.023 0.2687 1
0.4716 0.6579 1
0.3525 0.6531 1
0.0143 0.8028 0.5
0.1333 0.3433 1
0.0324 0.3378 1
0.0279 0.3059 1
3.3175 0.63 1
0.0493 0.2507 0.8379
0.0197 0.2644 1
0.1668 0.2538 1
0.1536 0.8947 1
0.0373 0.4466 1
3.2346 0.5716 1
0.0385 0.5087 1
0.0379 0.4073 1
0.0611 0.8952 1
0.0183 0.4958 0.6166
0.2466 0.4782 1
0.1166 0.3866 0.4095
0.0493 0.2507 0.8379
0.0373 0.4466 1
0.023 0.7733 1
0.0128 0.3532 1
0.0303 0.3359 0.865
0.4716 0.6579 1
0.0401 0.2502 1
0.0405 0.2734 0.5
0.0213 0.4208 1
0.0363 0.3734 1
0.023 0.3502 1
0.023 0.2616 0.5
0.023 0.6361 1
0.0405 0.2734 0.5
0.0507 0.2519 0.846
0.0324 0.3378 1
0.023 0.2558 1
0.0469 0.3505 1
0.1668 0.2538 1
0.2809 0.3348 1
0.0286 0.3614 1
0.0238 0.3244 1
0.0233 0.3128 1
0.0437 0.5008 1
0.0496 0.499 0.9249
0.2521 0.339 1
0.0637 0.7565 1
0.382 0.3066 1
0.0443 0.3294 0.5
5.9868 0.2974 1
2.3572 0.3518 1
0.0143 0.3565 1
0.023 0.2773 1
0.0264 0.2618 0.9335
0.2809 0.3348 1
0.2536 0.8813 1
0.0245 0.8215 1
0.0704 0.3975 0.8118
0.0377 0.6482 1
0.0373 0.4466 1
0.0153 0.3408 0.4995
0.2244 0.9224 1
0.023 0.2914 1
0.2209 0.7675 1
0.0924296 0.309096 0.602518
0.0654 0.4154 0.5
0.023 0.5081 1
0.2707 0.2951 1
0.023 0.4654 1
0.0124 0.3253 1
0.947 0.396 1
2.3572 0.3518 1
0.0809 0.8534 0.5
0.2511 0.9217 1
0.0118 0.3305 1
0.0628 0.4036 1
0.1938 0.4513 1
0.1482 0.356 1
0.0129 0.3625 0.3747
0.0272 0.2862 0.5
0.2209 0.7675 1
0.222 0.9209 1
0.023 0.8709 0.5
0.023 0.4467 0.6905
0.0296 0.2882 1
0.023 0.7253 1
0.0248 0.2562 0.5
0.1536 0.8947 1
0.0299 0.2799 1
0.1076 0.4197 1
0.0165 0.3007 0.4995
0.022 0.4811 1
0.0138 0.3675 1
0.2705 0.9985 1
0.0375 0.9969 1
0.0143 0.679 1
0.0389 0.2741 1
0.023 0.46 1
0.3015 0.7275 1
0.0645 0.3994 1
0.5388 0.5622 1
0.2466 0.4782 1
0.023 0.2846 0.5
0.0197 0.2644 1
0.947 0.396 1
0.024 0.2865 1
0.0591 0.3201 1
0.0382 0.4157 1
0.0789 0.9465 1
0.024 0.2535 1
0.0247 0.2559 1
3.5082 0.3846 1
0.2244 0.9224 1
0.0268 0.7531 0.9249
0.0272 0.2927 1
0.0235 0.3659 0.3637
0.0461 0.505 0.9249
0.0285 0.3263 1
0.0238 0.2547 0.8843
0.0238 0.2547 0.8843
0.382 0.3066 1
0.078 0.7951 1
0.3015 0.7275 1
0.0245 0.4131 1
0.0246 0.5819 0.8843
0.024 0.2535 1
0.023 0.2623 0.5
0.023 0.4654 1
0.0238 0.2846 0.6597
0.0156 0.4995 0.4995
0.0162 0.3209 0.6519
0.022 0.7645 1
0.1668 0.2538 1
0.0266 0.6858 0.9249
0.0118 0.2787 1
0.2705 0.9985 1
0.3568 0.4479 1
0.1076 0.4197 1
0.0226 0.6945 0.9249
0.038 0.408 1
0.0819 0.8322 1
0.0371 0.3349 1
0.023 0.3658 1
0.2809 0.3348 1
0.118 0.3571 1
0.0304 0.786 1
0.3778 0.8068 1
0.0417 0.3568 1
0.0443 0.3302 0.5
0.0114 0.4212 1
0.0264 0.2618 0.9335
0.0222 0.3329 0.3302
0.0111 0.6672 0.5
2.5479 0.3858 1
0.023 0.4654 1
0.44 0.6244 1
0.0212 0.6136 1
0.1668 0.2538 1
0.0959 0.6423 1
0.44 0.6244 1
0.0122 0.2527 1
0.0143 0.3405 0.5
0.0236 0.287 1
0.0972 0.6928 1
0.0263 0.6358 1
0.024 0.2535 1
0.0534 0.2785 1
0.023 0.8532 1
0.382 0.3066 1
0.0245 0.5825 0.4997
0.0245 0.5715 0.4883
0.0173 0.8016 1
0.2521 0.339 1
0.0488 0.2933 1
0.0246 0.8152 1
0.0813 0.9286 1
0.0233 0.2841 0.5
0.0894 0.5926 1
0.0788 0.8317 1
0.0134 0.3704 1
0.1074 0.2867 1
0.0789 0.9465 1
3.2332 0.3663 1
0.0293 0.2992 1
0.0507 0.2519 0.846
0.0492 0.2607 0.9249
2.5479 0.3858 1
0.0143 0.7732 0.5
0.023 0.3502 1
0.0375 0.6357 1
0.1025 0.3055 1
0.0441 0.2829 1
0.0253 0.2811 1
0.0245 0.5715 0.4883
0.023 0.279 1
0.2521 0.339 1
0.0375 0.4091 1
0.023 0.5408 1
0.2705 0.9985 1
0.0441 0.2829 1
0.0156 0.4995 0.4995
0.4751 0.3081 1
0.023 0.7695 1
0.2809 0.3348 1
0.0143 0.4647 0.5
0.0162 0.3209 0.6519
0.023 0.2866 1
0.0809 0.8534 0.5
0.023 0.515 1
0.023 0.3452 1
3.3664 0.6372 1
0.2521 0.339 1
0.1076 0.4197 1
0.0464 0.4963 1
0.0421 0.8435 1
0.0233 0.2874 1
0.0148 0.6166 0.6166
3.3664 0.6372 1
0.0327 0.3149 1
0.1166 0.3866 0.4095
0.0119 0.4304 1
0.023 0.3196 1
0.023 0.6552 1
0.0234 0.2802 1
0.0657 0.3596 1
0.0252 0.3063 1
0.023 0.3196 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier GL50803_14566 (Giardia lamblia), Dipeptidyl-peptidase I precursor
Title for this comment
Comment