Detailed information for compound 1009763

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 474.681 | Formula: C30H42N4O
  • H donors: 1 H acceptors: 1 LogP: 5.35 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(NCCN1CN(C2(C1=O)CCN(CC2)C1CCC(c2c1cccc2)(C)C)c1ccccc1)C
  • InChi: 1S/C30H42N4O/c1-23(2)31-18-21-33-22-34(24-10-6-5-7-11-24)30(28(33)35)16-19-32(20-17-30)27-14-15-29(3,4)26-13-9-8-12-25(26)27/h5-13,23,27,31H,14-22H2,1-4H3
  • InChiKey: DBUJJGVEYVDIRQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens opioid receptor, mu 1 Starlite/ChEMBL References
Homo sapiens opiate receptor-like 1 Starlite/ChEMBL References
Homo sapiens opioid receptor, delta 1 Starlite/ChEMBL References
Homo sapiens opioid receptor, kappa 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily Get druggable targets OG5_139759 All targets in OG5_139759
Echinococcus granulosus tm gpcr rhodopsin Get druggable targets OG5_139759 All targets in OG5_139759
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis growth hormone secretagogue receptor type 1 opiate receptor-like 1 370 aa 349 aa 22.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0047 0.009 0.0117
Schistosoma mansoni lipoxygenase 0.0078 0.0202 0.0265
Loa Loa (eye worm) CXXC zinc finger family protein 0.0064 0.0153 0.0495
Schistosoma mansoni hypothetical protein 0.0076 0.0197 0.0258
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0134 0.0175
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0046 0.0086 0.0113
Loa Loa (eye worm) hypothetical protein 0.0247 0.0817 0.2646
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0047 0.009 0.0117
Loa Loa (eye worm) ICD-1 protein 0.0034 0.0043 0.0138
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0031 0.0031 0.0043
Schistosoma mansoni smad 0.0025 0.0009 0.0012
Plasmodium vivax vivapain-2 0.0024 0.0008 0.0025
Mycobacterium ulcerans DNA polymerase IV 0.0084 0.0225 0.0836
Echinococcus multilocularis beta adrenergic receptor kinase 0.0031 0.0031 0.004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0093 0.0257 0.0956
Trichomonas vaginalis Heterochromatin protein, putative 0.0026 0.0014 0.0014
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0143 0.0439 0.0575
Giardia lamblia Heat shock protein HSP 90-alpha 0.0068 0.0168 0.0348
Echinococcus multilocularis beta LACTamase domain containing family member 0.0054 0.0118 0.0154
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0047 0.0092 0.012
Brugia malayi Metabotropic glutamate receptor precursor. 0.0034 0.0043 0.0059
Echinococcus multilocularis DNA topoisomerase 1 0.02 0.0647 0.0848
Loa Loa (eye worm) hypothetical protein 0.003 0.0029 0.0095
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0027 0.0017 0.0056
Schistosoma mansoni smad1 5 8 and 0.0025 0.0009 0.0012
Leishmania major hypothetical protein, conserved 0.003 0.0029 0.0103
Plasmodium vivax JmjC domain containing protein 0.003 0.0029 0.0103
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0057 0.0127 0.0167
Schistosoma mansoni serine/threonine protein kinase 0.0624 0.2187 0.2865
Leishmania major CYC2-like cyclin, putative 0.003 0.003 0.0106
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0025 0.001 0.0013
Echinococcus granulosus dnaJ subfamily B 0.0913 0.3237 0.4239
Echinococcus granulosus Chromobox protein 3 0.0026 0.0014 0.0019
Plasmodium falciparum heat shock protein 90, putative 0.0196 0.0633 0.2365
Loa Loa (eye worm) hypothetical protein 0.0106 0.0305 0.0989
Entamoeba histolytica hypothetical protein 0.0083 0.0222 0.0498
Loa Loa (eye worm) hypothetical protein 0.0022 0.0002 0.0005
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0072 0.0183 0.0391
Leishmania major heat shock protein 83-1 0.0082 0.0219 0.0812
Loa Loa (eye worm) hypothetical protein 0.0047 0.009 0.029
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0024 0.0008 0.0025
Trichomonas vaginalis D-aminoacylase, putative 0.0054 0.0118 0.0255
Echinococcus multilocularis phd:f box containing protein 0.003 0.0029 0.0038
Mycobacterium ulcerans beta-lactamase 0.0054 0.0118 0.0295
Brugia malayi Telomerase reverse transcriptase 0.2017 0.7247 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0047 0.009 0.0117
Plasmodium falciparum heat shock protein 90 0.0082 0.0219 0.0813
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0024 0.0008 0.0025
Brugia malayi Cathepsin L-like precursor 0.0024 0.0008 0.0012
Brugia malayi Cathepsin L-like precursor 0.0024 0.0008 0.0012
Echinococcus granulosus FTZ F1 alpha 0.0047 0.009 0.0117
Trichomonas vaginalis rheb, putative 0.0061 0.0141 0.031
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0092 0.0253 0.1003
Brugia malayi MH1 domain containing protein 0.0025 0.0009 0.0013
Loa Loa (eye worm) hypothetical protein 0.0028 0.002 0.0064
Trypanosoma cruzi heat shock protein 85, putative 0.0082 0.0219 0.0812
Loa Loa (eye worm) hypothetical protein 0.0042 0.0071 0.0231
Schistosoma mansoni lipoxygenase 0.0054 0.0117 0.0154
Echinococcus multilocularis JmjC domain containing protein 4 0.003 0.0029 0.0038
Brugia malayi bHLH-PAS transcription factor 0.0038 0.0059 0.0081
Trypanosoma brucei unspecified product 0.0038 0.0059 0.0216
Leishmania major cysteine peptidase A (CPA) 0.0024 0.0008 0.0025
Mycobacterium tuberculosis Probable hydrolase 0.0054 0.0118 0.0328
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0051 0.0105 0.0138
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0258 0.0337
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0046 0.0086 0.0317
Schistosoma mansoni jumonji domain containing protein 0.003 0.0029 0.0038
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0093 0.0257 0.0956
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0069 0.0172 0.0556
Schistosoma mansoni hypothetical protein 0.0093 0.0259 0.0339
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0046 0.0086 0.0113
Trypanosoma cruzi cdc2-related kinase 1 0.0059 0.0134 0.0494
Giardia lamblia Kinase, AGC PKA 0.0046 0.0086 0.0156
Echinococcus granulosus beta-adrenergic receptor kinase 0.0031 0.0031 0.004
Schistosoma mansoni chromobox protein 0.0026 0.0014 0.0019
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0126 0.0379 0.1412
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0041 0.0067 0.0137
Brugia malayi RNA recognition motif domain containing protein 0.0206 0.0669 0.0923
Leishmania major cathepsin L-like protease 0.0024 0.0008 0.0025
Schistosoma mansoni endoplasmin 0.0082 0.0219 0.0287
Loa Loa (eye worm) glutathione reductase 0.004 0.0066 0.0213
Echinococcus multilocularis polycomb protein SCMH1 0.005 0.0102 0.0134
Loa Loa (eye worm) hypothetical protein 0.0038 0.0059 0.0192
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0217 0.0706 0.0975
Plasmodium vivax SET domain protein, putative 0.0126 0.0379 0.1412
Schistosoma mansoni transcription factor btf3 0.0034 0.0043 0.0056
Brugia malayi Thioredoxin reductase 0.004 0.0066 0.0091
Mycobacterium tuberculosis Probable esterase LipL 0.0054 0.0118 0.0328
Trypanosoma brucei unspecified product 0.0038 0.0059 0.0216
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0758 0.2673 1
Echinococcus granulosus lysine specific demethylase 6a 0.003 0.0029 0.0038
Toxoplasma gondii heat shock protein HSP90 0.0082 0.0219 0.0813
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0102 0.0134
Entamoeba histolytica hypothetical protein 0.0026 0.0014 0.0014
Echinococcus granulosus defective proboscis extension response 0.0031 0.0034 0.0045
Loa Loa (eye worm) ctsf protein 0.0024 0.0008 0.0027
Brugia malayi Bromodomain containing protein 0.0076 0.0196 0.0271
Brugia malayi nuclear receptor RXR 0.0025 0.001 0.0013
Toxoplasma gondii PHD-finger domain-containing protein 0.0093 0.0259 0.0962
Brugia malayi Bromodomain containing protein 0.0037 0.0054 0.0075
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0041 0.0067 0.0137
Echinococcus granulosus casein kinase I delta 0.0624 0.2187 0.2865
Schistosoma mansoni jumonji domain containing protein 0.0243 0.0801 0.1049
Entamoeba histolytica phosphofructokinase, putative 0.0121 0.0361 0.0824
Plasmodium vivax hypothetical protein, conserved 0.0026 0.0014 0.0048
Echinococcus multilocularis rho associated protein kinase 0.0143 0.0439 0.0575
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.005 0.0102 0.0134
Echinococcus multilocularis Immunoglobulin 0.0031 0.0034 0.0045
Brugia malayi Cathepsin L-like precursor 0.0024 0.0008 0.0012
Leishmania major heat shock protein 83-1 0.0082 0.0219 0.0812
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.003 0.0029 0.0103
Trichomonas vaginalis DNA polymerase eta, putative 0.0084 0.0225 0.0507
Leishmania major heat shock protein 83-1 0.0082 0.0219 0.0812
Schistosoma mansoni kinase 0.0062 0.0147 0.0192
Toxoplasma gondii cyclin, N-terminal domain-containing protein 0.003 0.003 0.0107
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0084 0.0306
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0031
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0047 0.0092 0.0201
Trypanosoma cruzi DNA topoisomerase type IB small subunit, putative 0.005 0.0103 0.0378
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0026 0.0014 0.0019
Onchocerca volvulus 0.0061 0.0141 0.0141
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0134 0.0293
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1635 0.586 0.7675
Brugia malayi ImpB/MucB/SamB family protein 0.008 0.0212 0.0292
Echinococcus multilocularis neuropeptide s receptor 0.1131 0.4029 0.5277
Echinococcus multilocularis cpg binding protein 0.007 0.0173 0.0226
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0642 0.2253 0.2951
Onchocerca volvulus 0.0054 0.0118 0.0118
Onchocerca volvulus 0.0095 0.0265 0.0265
Schistosoma mansoni hypothetical protein 0.0148 0.0458 0.0599
Loa Loa (eye worm) hypothetical protein 0.0247 0.0817 0.2646
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0026 0.0014 0.0019
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0031
Plasmodium falciparum glutathione reductase 0.004 0.0066 0.024
Echinococcus granulosus Chromo domain 0.0026 0.0014 0.0019
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0121 0.0361 0.1544
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0051 0.0107 0.024
Trypanosoma cruzi cysteine peptidase, putative 0.0024 0.0008 0.0025
Onchocerca volvulus 0.0428 0.1474 0.1474
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0038 0.0059 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0047 0.009 0.009
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0036 0.0049 0.0064
Echinococcus granulosus beta LACTamase domain containing family member 0.0054 0.0118 0.0154
Echinococcus multilocularis PHD finger protein rhinoceros 0.0093 0.0259 0.0339
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0047 0.009 0.029
Onchocerca volvulus Cathepsin F homolog 0.0024 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0026 0.0014 0.0047
Schistosoma mansoni survival motor neuron protein 0.0076 0.0197 0.0258
Echinococcus multilocularis ribosomal protein L19 0.0028 0.002 0.0026
Trichomonas vaginalis chromobox protein, putative 0.0159 0.0497 0.1143
Loa Loa (eye worm) hypothetical protein 0.0148 0.0458 0.1481
Entamoeba histolytica casein kinase, putative 0.0624 0.2187 0.509
Mycobacterium tuberculosis Probable reductase 0.0092 0.0253 0.1003
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0045 0.0084 0.0306
Onchocerca volvulus Alhambra homolog 0.0093 0.0259 0.0259
Mycobacterium ulcerans lipase LipD 0.0054 0.0118 0.0295
Brugia malayi Protein kinase domain containing protein 0.0426 0.1466 0.2023
Entamoeba histolytica acyl-CoA synthetase, putative 0.0051 0.0107 0.0229
Loa Loa (eye worm) hypothetical protein 0.0047 0.009 0.029
Loa Loa (eye worm) hypothetical protein 0.0051 0.0107 0.0345
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.003 0.0029 0.0038
Trichomonas vaginalis phosphofructokinase, putative 0.0121 0.0361 0.0824
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0014 0.0014
Echinococcus multilocularis casein kinase i 0.0624 0.2187 0.2865
Brugia malayi Cathepsin L-like precursor 0.0024 0.0008 0.0012
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0046 0.0086 0.0113
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0069 0.0172 0.0637
Echinococcus granulosus ribosomal protein L19 0.0028 0.002 0.0026
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.005 0.0102 0.0102
Schistosoma mansoni heat shock protein 0.0082 0.0219 0.0287
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0047 0.009 0.0124
Loa Loa (eye worm) hypothetical protein 0.0042 0.0071 0.0229
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0046 0.0086 0.0316
Echinococcus multilocularis sterol regulatory element binding protein 0.0027 0.0017 0.0023
Toxoplasma gondii casein kinase I 0.0624 0.2187 0.8182
Onchocerca volvulus 0.0024 0.0008 0.0008
Brugia malayi 6-phosphofructokinase 0.0121 0.0361 0.0498
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1203 0.4289 1
Echinococcus multilocularis expressed protein 0.0417 0.1434 0.1879
Leishmania major DNA polymerase kappa, putative 0.0063 0.0148 0.0547
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0321 0.1084 0.4052
Schistosoma mansoni hypothetical protein 0.0026 0.0014 0.0019
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0102 0.029 0.094
Onchocerca volvulus 0.0076 0.0197 0.0197
Echinococcus granulosus lamin 0.0061 0.0141 0.0185
Echinococcus multilocularis FTZ F1 alpha 0.0047 0.009 0.0117
Echinococcus granulosus twitchin 0.0044 0.0079 0.0104
Trypanosoma brucei 60S ribosomal protein L19, putative 0.0028 0.002 0.0068
Onchocerca volvulus Cathepsin L homolog 0.0024 0.0008 0.0008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0047 0.009 0.029
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1203 0.4289 1
Leishmania major heat shock protein 83-1 0.0082 0.0219 0.0812
Brugia malayi RNA binding protein 0.0206 0.0669 0.0923
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0041 0.0067 0.0137
Loa Loa (eye worm) PHD-finger family protein 0.0093 0.0259 0.0837
Plasmodium vivax hypothetical protein, conserved 0.0026 0.0014 0.0048
Loa Loa (eye worm) transcription factor SMAD2 0.0362 0.1233 0.3993
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1203 0.4289 1
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0149 0.0329
Loa Loa (eye worm) hypothetical protein 0.0061 0.0141 0.0457
Leishmania major heat shock protein 83-1 0.0082 0.0219 0.0812
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.0335 0.0439
Echinococcus granulosus metabotropic glutamate receptor 5 0.0042 0.0071 0.0093
Trichomonas vaginalis heat shock protein, putative 0.0042 0.0072 0.015
Trypanosoma brucei hypothetical protein, conserved 0.0054 0.0118 0.0434
Echinococcus granulosus Protein patched homolog 1 0.0027 0.0017 0.0023
Schistosoma mansoni retinoic acid receptor RXR 0.0047 0.009 0.0117
Echinococcus granulosus intermediate filament protein 0.0061 0.0141 0.0185
Trichomonas vaginalis rap1 and, putative 0.0061 0.0141 0.031
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0047 0.009 0.0117
Echinococcus granulosus casein kinase I delta 0.0624 0.2187 0.2865
Loa Loa (eye worm) DNA topoisomerase I 0.02 0.0647 0.2095
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0121 0.0361 0.1306
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0039 0.0072
Echinococcus multilocularis survival motor neuron protein 1 0.0374 0.128 0.1676
Onchocerca volvulus 0.0054 0.0118 0.0118
Onchocerca volvulus 0.0038 0.0059 0.0059
Schistosoma mansoni hypothetical protein 0.0069 0.0169 0.0221
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0012 0.0016
Echinococcus multilocularis cyclin dependent kinase 1 0.0059 0.0134 0.0175
Trichomonas vaginalis conserved hypothetical protein 0.0089 0.0244 0.055
Echinococcus granulosus casein kinase I alpha 0.0624 0.2187 0.2865
Trichomonas vaginalis chromobox protein, putative 0.0026 0.0014 0.0014
Entamoeba histolytica transcription factor BTF3, putative 0.0034 0.0043 0.008
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1203 0.4289 1
Mycobacterium ulcerans 6-phosphofructokinase 0.0121 0.0361 0.1515
Echinococcus multilocularis zinc finger protein 0.0023 0.0002 0.0002
Mycobacterium ulcerans aldehyde dehydrogenase 0.0047 0.0092 0.0167
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0047 0.009 0.0117
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0201 0.0648 0.0849
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0047 0.009 0.0124
Echinococcus granulosus importin subunit beta 1 0.0022 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.006 0.0137 0.0444
Echinococcus multilocularis casein kinase I delta 0.0624 0.2187 0.2865
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0009 0.0012
Echinococcus multilocularis cysteine protease 0.0024 0.0008 0.0011
Loa Loa (eye worm) mbt repeat family protein 0.005 0.0102 0.033
Brugia malayi Papain family cysteine protease containing protein 0.0024 0.0008 0.0012
Onchocerca volvulus 0.0624 0.2187 0.2187
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0043 0.008
Onchocerca volvulus 0.0051 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0031 0.0034 0.0111
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0025 0.001 0.0013
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0047 0.009 0.0117
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0031 0.004
Plasmodium falciparum protein kinase 5 0.0059 0.0134 0.0495
Leishmania major casein kinase, putative 0.0624 0.2187 0.8182
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0017 0.0021
Echinococcus granulosus dna polymerase eta 0.008 0.0212 0.0277
Trypanosoma cruzi cysteine peptidase, putative 0.0093 0.0257 0.0955
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0059 0.0134 0.0433
Schistosoma mansoni hypothetical protein 0.024 0.0792 0.1037
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.0335 0.0462
Entamoeba histolytica hypothetical protein 0.0083 0.0222 0.0498
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0588 0.2054 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0069 0.0169 0.0221
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0624 0.2187 0.7081
Echinococcus multilocularis Niemann Pick C1 protein 0.0062 0.0147 0.0192
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0057 0.0127 0.0175
Trypanosoma brucei DNA topoisomerase type IB small subunit 0.005 0.0103 0.0378
Echinococcus granulosus casein kinase I alpha 0.0624 0.2187 0.2865
Plasmodium falciparum acyl-CoA synthetase 0.0038 0.0059 0.0216
Toxoplasma gondii heat shock protein 75, putative 0.0046 0.0087 0.0319
Loa Loa (eye worm) thioredoxin reductase 0.004 0.0066 0.0213
Loa Loa (eye worm) hypothetical protein 0.0062 0.0147 0.0475
Trichomonas vaginalis dexras1, putative 0.0061 0.0141 0.031
Trichomonas vaginalis chromobox protein, putative 0.0026 0.0014 0.0014
Echinococcus granulosus phd:f box containing protein 0.003 0.0029 0.0038
Trypanosoma cruzi casein kinase, putative 0.0624 0.2187 0.8182
Echinococcus multilocularis geminin 0.0278 0.093 0.1219
Schistosoma mansoni hypothetical protein 0.0069 0.0169 0.0221
Brugia malayi AF-10 protein 0.003 0.0031 0.0042
Trichomonas vaginalis heat shock protein, putative 0.0056 0.0123 0.0268
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0024 0.0008 0.0011
Brugia malayi SET domain containing protein 0.0032 0.0036 0.005
Trichomonas vaginalis chromobox protein, putative 0.0159 0.0497 0.1143
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0047 0.009 0.0124
Entamoeba histolytica hypothetical protein 0.0083 0.0222 0.0498
Plasmodium vivax heat shock protein 90, putative 0.0046 0.0087 0.0319
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0046 0.0087 0.0114
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.007 0.0174 0.0562
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0038 0.0059 0.0003
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0046 0.0086 0.0316
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0093 0.0257 0.0956
Echinococcus multilocularis Chromobox protein 3 0.0026 0.0014 0.0019
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0047 0.009 0.0117
Schistosoma mansoni chromobox protein 0.0159 0.0497 0.0652
Schistosoma mansoni coup transcription factor 0.0047 0.009 0.0117
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0014 0.0014
Brugia malayi TAR-binding protein 0.0206 0.0669 0.0923
Brugia malayi jmjC domain containing protein 0.003 0.0029 0.004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0093 0.0257 0.0956
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0059 0.0134 0.0433
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0069 0.0172 0.0382
Onchocerca volvulus 0.0024 0.0008 0.0008
Trichomonas vaginalis penicillin-binding protein, putative 0.0054 0.0118 0.0255
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0054 0.0118 0.0162
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0009 0.0012
Schistosoma mansoni Smad4 0.0025 0.0009 0.0012
Entamoeba histolytica deoxycytidyl transferase, putative 0.0056 0.0122 0.0266
Onchocerca volvulus 0.0026 0.0014 0.0014
Brugia malayi heat shock protein 90 0.0082 0.0219 0.0302
Echinococcus granulosus single minded 2 0.0038 0.0059 0.0077
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0026 0.0014 0.0048
Trypanosoma brucei unspecified product 0.0077 0.02 0.0742
Onchocerca volvulus 0.0061 0.0141 0.0141
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0061 0.0141 0.0457
Schistosoma mansoni nephrin 0.0035 0.0046 0.0061
Loa Loa (eye worm) hypothetical protein 0.0028 0.0023 0.0073
Echinococcus granulosus GPCR family 2 0.0069 0.0169 0.0221
Schistosoma mansoni hypothetical protein 0.0026 0.0014 0.0018
Schistosoma mansoni hypothetical protein 0.0026 0.0014 0.0018
Plasmodium vivax topoisomerase I, putative 0.02 0.0647 0.2417
Onchocerca volvulus 0.0143 0.0439 0.0439
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0092 0.0253 0.1003
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0069 0.0169 0.0233
Loa Loa (eye worm) phosphofructokinase 0.0121 0.0361 0.1168
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0047 0.009 0.0124
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0014 0.0014
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0026 0.0014 0.0048
Echinococcus multilocularis chromobox protein 1 0.0159 0.0497 0.0652
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0092 0.0253 0.0749
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0031
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0047 0.009 0.0117
Trichomonas vaginalis ras-dva small GTPase, putative 0.0061 0.0141 0.031
Toxoplasma gondii thioredoxin reductase 0.004 0.0066 0.024
Brugia malayi latrophilin 2 splice variant baaae 0.0148 0.0458 0.0631
Echinococcus multilocularis tar DNA binding protein 0.0206 0.0669 0.0876
Loa Loa (eye worm) hypothetical protein 0.0061 0.0141 0.0457
Leishmania major heat shock protein 83-1 0.0082 0.0219 0.0812
Brugia malayi Endoplasmin precursor 0.0082 0.0219 0.0302
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0047 0.009 0.0124
Mycobacterium ulcerans hypothetical protein 0.0051 0.0107 0.024
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0059 0.0134 0.0433
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0624 0.2187 0.7081
Loa Loa (eye worm) MBCTL1 0.0057 0.0127 0.0412
Trypanosoma cruzi cdc2-related kinase 3 0.0059 0.0134 0.0494
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0083 0.0222 0.029
Schistosoma mansoni phd/f-box containing protein 0.003 0.0029 0.0038
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0047 0.009 0.0117
Loa Loa (eye worm) hypothetical protein 0.0045 0.0083 0.0268
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0054 0.0118 0.0154
Loa Loa (eye worm) hypothetical protein 0.0037 0.0055 0.0177
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1203 0.4289 1
Brugia malayi hypothetical protein 0.0026 0.0014 0.002
Trichomonas vaginalis chromobox protein, putative 0.0096 0.0268 0.0607
Schistosoma mansoni 6-phosphofructokinase 0.0121 0.0361 0.0473
Echinococcus multilocularis transcription factor btf3 0.0034 0.0043 0.0056
Brugia malayi chromobox protein homolog 3 0.0089 0.0244 0.0336
Onchocerca volvulus 0.0993 0.3526 0.3526
Schistosoma mansoni cathepsin F (C01 family) 0.0024 0.0008 0.0011
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.0225 0.0838
Schistosoma mansoni DNA polymerase eta 0.008 0.0212 0.0277
Loa Loa (eye worm) hypothetical protein 0.0038 0.0059 0.0192
Trypanosoma cruzi DNA polymerase kappa, putative 0.0084 0.0225 0.0837
Giardia lamblia Kinase, CMGC CDK 0.0059 0.0134 0.0267
Trypanosoma brucei DNA polymerase IV, putative 0.0077 0.02 0.0742
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0026 0.0014 0.0048
Loa Loa (eye worm) hypothetical protein 0.0054 0.0118 0.038
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0026 0.0014 0.002
Trypanosoma brucei DNA polymerase IV, putative 0.0084 0.0225 0.0838
Mycobacterium leprae conserved hypothetical protein 0.0054 0.0118 0.0056
Toxoplasma gondii RNA-directed DNA polymerase 0.0758 0.2673 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0025 0.001 0.0013
Onchocerca volvulus Bile acid receptor homolog 0.0047 0.009 0.009
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0056 0.0122 0.0395
Schistosoma mansoni nuclear hormone receptor 0.0047 0.009 0.0117
Trypanosoma brucei 60S ribosomal protein L19, putative 0.0028 0.002 0.0068
Loa Loa (eye worm) hypothetical protein 0.0051 0.0107 0.0345
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0014 0.0014
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0047 0.009 0.0117
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0028 0.0023 0.003
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0335 0.0763
Trichomonas vaginalis heat shock protein, putative 0.0082 0.0219 0.0492
Brugia malayi Pre-SET motif family protein 0.0126 0.0379 0.0523
Onchocerca volvulus 0.0047 0.009 0.009
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0047 0.009 0.0124
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0059 0.0134 0.0175
Trypanosoma cruzi 60S ribosomal protein L19, putative 0.0028 0.002 0.0068
Leishmania major protein kinase A catalytic subunit isoform 2 0.0046 0.0086 0.0316
Trichomonas vaginalis chromobox protein, putative 0.0026 0.0014 0.0014
Schistosoma mansoni hypothetical protein 0.0278 0.093 0.1219
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0039 0.0072
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0041 0.0067 0.0137
Loa Loa (eye worm) hypothetical protein 0.0054 0.0118 0.038
Echinococcus multilocularis SAM and MBT domain containing protein 0.005 0.0102 0.0134
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0069 0.0169 0.0221
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.0335 0.1085
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0093 0.0257 0.0956
Brugia malayi casein kinase 1, delta 0.0624 0.2187 0.3018
Echinococcus multilocularis ecdysone induced protein 78C 0.0047 0.009 0.0117
Trypanosoma cruzi CYC2-like cyclin 6, putative 0.003 0.003 0.0106
Trypanosoma cruzi cysteine peptidase, putative 0.0093 0.0257 0.0955
Trypanosoma brucei heat shock protein, putative 0.0082 0.0219 0.0813
Loa Loa (eye worm) hypothetical protein 0.0031 0.0034 0.0111
Plasmodium falciparum JmjC domain-containing protein, putative 0.003 0.0029 0.0103
Loa Loa (eye worm) hypothetical protein 0.0054 0.0118 0.038
Trypanosoma cruzi 60S ribosomal protein L19, putative 0.0028 0.002 0.0068
Loa Loa (eye worm) helicase 0.0026 0.0014 0.0047
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0172 0.0637
Loa Loa (eye worm) hypothetical protein 0.0024 0.0008 0.0027
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0063 0.0148 0.0547
Echinococcus multilocularis protein patched 0.0027 0.0017 0.0023
Giardia lamblia PHD finger protein 15 0.0093 0.0259 0.0559
Brugia malayi Nuclear hormone receptor-like 1 0.0025 0.001 0.0013
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0057 0.0127 0.0167
Leishmania major heat shock protein 83-1 0.0082 0.0219 0.0812
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0056 0.0122 0.016
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0014 0.0014
Echinococcus multilocularis dna polymerase kappa 0.0084 0.0225 0.0295
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0093 0.0257 0.0956
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0039 0.014
Trypanosoma brucei heat shock protein, putative 0.0082 0.0219 0.0813
Echinococcus granulosus histone acetyltransferase MYST2 0.0057 0.0127 0.0167
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0047 0.009 0.0117
Onchocerca volvulus 0.0024 0.0008 0.0008
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.0335 0.0439
Loa Loa (eye worm) hypothetical protein 0.0089 0.0244 0.0789
Loa Loa (eye worm) hypothetical protein 0.0057 0.0127 0.0412
Mycobacterium tuberculosis Probable oxidoreductase 0.0102 0.029 0.1188
Echinococcus granulosus ribosomal protein L19 0.0028 0.002 0.0026
Brugia malayi cell division control protein 2 homolog 0.0059 0.0134 0.0185
Echinococcus multilocularis Chromo domain 0.0026 0.0014 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0047 0.009 0.0124
Loa Loa (eye worm) hypothetical protein 0.003 0.0029 0.0095
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0102 0.0134
Trichomonas vaginalis conserved hypothetical protein 0.003 0.003 0.0051
Echinococcus granulosus SAM and MBT domain containing protein 0.005 0.0102 0.0134
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0047 0.009 0.0117
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0258 0.0337
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0026 0.0014 0.0048
Schistosoma mansoni single-minded 0.0052 0.0107 0.0141
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0054 0.0118 0.0328
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0025 0.001 0.0013
Onchocerca volvulus Cathepsin L homolog 0.0024 0.0008 0.0008
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0009 0.0012
Loa Loa (eye worm) hypothetical protein 0.0143 0.0439 0.142
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0024 0.0008 0.0027
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0046 0.0086 0.0316
Loa Loa (eye worm) hypoxia-induced factor 1 0.016 0.05 0.162
Brugia malayi cytoplasmic intermediate filament protein 0.0033 0.0038 0.0053
Trichomonas vaginalis 60S ribosomal protein L19, putative 0.0028 0.002 0.0027
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0072 0.0183 0.5
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0029 0.0027 0.0035
Schistosoma mansoni vesicular amine transporter 0.0031 0.0034 0.0045
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0086 0.0113
Onchocerca volvulus 0.0054 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0026 0.0014 0.0047
Trypanosoma cruzi casein kinase, putative 0.0624 0.2187 0.8182
Echinococcus multilocularis dnaJ subfamily B 0.0913 0.3237 0.4239
Loa Loa (eye worm) hypothetical protein 0.0374 0.128 0.4143
Trichomonas vaginalis 60S ribosomal protein L19, putative 0.0028 0.002 0.0027
Echinococcus multilocularis cyclin dependent kinase 0.0059 0.0134 0.0175
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0026 0.0014 0.0019
Schistosoma mansoni transcription factor LCR-F1 0.0083 0.0222 0.029
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0047 0.0092 0.012
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0014 0.0014
Plasmodium vivax hypothetical protein, conserved 0.0054 0.0118 0.0434
Trypanosoma brucei cdc2-related kinase 1 0.0059 0.0134 0.0495
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0093 0.0257 0.0956
Brugia malayi PHD-finger family protein 0.0093 0.0259 0.0357
Echinococcus granulosus cpg binding protein 0.007 0.0173 0.0226
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0038 0.0059 0.0077
Loa Loa (eye worm) hypothetical protein 0.005 0.0101 0.0326
Schistosoma mansoni hypothetical protein 0.0278 0.093 0.1219
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0047 0.009 0.029
Schistosoma mansoni hypothetical protein 0.0083 0.0222 0.029
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0096 0.0268 0.0268
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0062 0.0147 0.0323
Echinococcus granulosus cathepsin l cysteine peptidase 0.0024 0.0008 0.0011
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0085 0.0312
Schistosoma mansoni hypothetical protein 0.0026 0.0014 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0043 0.008
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0288 0.0966 0.1265
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0014 0.0014
Brugia malayi 6-phosphofructokinase 0.0121 0.0361 0.0498
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0072 0.0183 0.0654
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0305 0.1029 0.1348
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0093 0.0257 0.0956
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0033 0.0038 0.0124
Loa Loa (eye worm) hypothetical protein 0.0047 0.009 0.029
Schistosoma mansoni smad1 5 8 and 0.0025 0.0009 0.0012
Onchocerca volvulus 0.0152 0.0473 0.0473
Echinococcus multilocularis neuropeptide receptor A26 0.1131 0.4029 0.5277
Echinococcus granulosus neuroglian 0.0035 0.0046 0.0061
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0093 0.0257 0.0956
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0084 0.0306
Loa Loa (eye worm) hypothetical protein 0.0027 0.0017 0.0056
Echinococcus multilocularis peregrin 0.0096 0.0267 0.0349
Trichomonas vaginalis 60S ribosomal protein L19, putative 0.0028 0.002 0.0027
Loa Loa (eye worm) jmjC domain-containing protein 0.003 0.0029 0.0095
Loa Loa (eye worm) hypothetical protein 0.0047 0.009 0.029
Entamoeba histolytica hypothetical protein 0.0034 0.0043 0.008
Trypanosoma cruzi DNA polymerase kappa, putative 0.0084 0.0225 0.0837
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0134 0.0293
Brugia malayi hypothetical protein 0.0025 0.001 0.0013
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0335 0.0763
Onchocerca volvulus 0.005 0.0102 0.0102
Mycobacterium ulcerans acyl-CoA synthetase 0.0051 0.0107 0.024
Onchocerca volvulus 0.0064 0.0153 0.0153
Echinococcus granulosus Smad4 0.0025 0.0009 0.0012
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0036 0.0049 0.0064
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0009 0.0012
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0258 0.0337
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0085 0.0228 0.0846
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0037 0.0053 0.007
Schistosoma mansoni RAR-like nuclear receptor 0.0047 0.009 0.0117
Brugia malayi ImpB/MucB/SamB family protein 0.0056 0.0122 0.0169
Loa Loa (eye worm) hypothetical protein 0.0047 0.009 0.029
Echinococcus multilocularis ras gtpase 0.0061 0.0141 0.0185
Leishmania major DNA topoisomerase IB, large subunit 0.015 0.0464 0.1732
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0047 0.009 0.0124
Echinococcus granulosus histone lysine methyltransferase setb 0.0143 0.0439 0.0575
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.0225 0.0838
Loa Loa (eye worm) heterochromatin protein 1 0.0159 0.0497 0.161
Brugia malayi beta-lactamase family protein 0.0054 0.0118 0.0162
Loa Loa (eye worm) Smad1 0.0025 0.0009 0.003
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0201 0.0648 0.0849
Trichomonas vaginalis CK1 family protein kinase 0.0624 0.2187 0.509
Leishmania major heat shock protein 83-1 0.0082 0.0219 0.0812
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0009 0.0012
Schistosoma mansoni cathepsin F (C01 family) 0.0024 0.0008 0.0011
Brugia malayi beta-lactamase 0.0054 0.0118 0.0162
Loa Loa (eye worm) AGC/PKA protein kinase 0.0046 0.0086 0.0279
Onchocerca volvulus Huntingtin homolog 0.0247 0.0817 0.0817
Toxoplasma gondii PHD-finger domain-containing protein 0.0093 0.0259 0.0962
Loa Loa (eye worm) hypothetical protein 0.0054 0.0118 0.038
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1203 0.4289 1
Echinococcus multilocularis 6 phosphofructokinase 0.0121 0.0361 0.0473
Schistosoma mansoni tar DNA-binding protein 0.0206 0.0669 0.0876
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0046 0.0086 0.0316
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0089 0.0244 0.0244
Echinococcus granulosus DNA topoisomerase 1 0.02 0.0647 0.0848
Schistosoma mansoni thyroid hormone receptor 0.0047 0.009 0.0117
Treponema pallidum fructose-bisphosphate aldolase 0.1203 0.4289 1
Toxoplasma gondii heat shock protein 90, putative 0.0082 0.0219 0.0813
Trypanosoma cruzi hypothetical protein, conserved 0.0054 0.0118 0.0433
Loa Loa (eye worm) runx1 0.0054 0.0115 0.0372
Mycobacterium tuberculosis Probable dehydrogenase 0.0092 0.0253 0.1003
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0046 0.0086 0.0119
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0031 0.0031 0.01
Brugia malayi beta-lactamase family protein 0.0054 0.0118 0.0162
Trypanosoma cruzi CYC2-like cyclin, putative 0.003 0.003 0.0106
Echinococcus multilocularis lysine specific demethylase 5A 0.0113 0.033 0.0432
Leishmania major heat shock protein 83-1 0.0082 0.0219 0.0812
Loa Loa (eye worm) jmjC domain-containing protein 0.0118 0.035 0.1132
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0033 0.0039 0.014
Plasmodium falciparum thioredoxin reductase 0.004 0.0066 0.024
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0012 0.0016
Brugia malayi mbt repeat family protein 0.005 0.0102 0.0141
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0172 0.0637
Leishmania major heat shock protein 83-1 0.0082 0.0219 0.0812
Plasmodium vivax casein kinase 1, putative 0.0624 0.2187 0.8182
Trypanosoma brucei heat shock protein 90, putative 0.0082 0.0219 0.0813
Brugia malayi photoreceptor-specific nuclear receptor 0.0047 0.009 0.0124
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.0335 0.0763
Toxoplasma gondii aldehyde dehydrogenase 0.0047 0.0092 0.0338
Schistosoma mansoni lozenge 0.0054 0.0115 0.015
Leishmania major mitochondrial DNA polymerase beta 0.0321 0.1084 0.4052
Brugia malayi polk-prov protein 0.0046 0.0086 0.0119
Trypanosoma brucei casein kinase I, isoform 2 0.0624 0.2187 0.8182
Echinococcus granulosus rho-associated protein kinase 1 0.0143 0.0439 0.0575
Echinococcus multilocularis lysine specific demethylase 6a 0.003 0.0029 0.0038
Loa Loa (eye worm) cysteine protease 0.0024 0.0008 0.0027
Brugia malayi Intermediate filament tail domain containing protein 0.0061 0.0141 0.0195
Brugia malayi Protein kinase domain containing protein 0.0059 0.0134 0.0185
Echinococcus granulosus 6 phosphofructokinase 0.0121 0.0361 0.0473
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0032 0.0034 0.0045
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0086 0.0113
Echinococcus multilocularis snurportin 1 0.024 0.0792 0.1037
Loa Loa (eye worm) hypothetical protein 0.0069 0.0169 0.0546
Schistosoma mansoni metabotropic glutamate receptor 0.0028 0.0023 0.003
Giardia lamblia Grp94/Hsp90 0.0072 0.0183 0.0382
Schistosoma mansoni lamin 0.0061 0.0141 0.0185
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0037 0.0053 0.007
Loa Loa (eye worm) hypothetical protein 0.0055 0.0121 0.039
Entamoeba histolytica acyl-CoA synthetase, putative 0.0051 0.0107 0.0229
Echinococcus granulosus Immunoglobulin 0.0031 0.0034 0.0045
Echinococcus multilocularis protein dispatched 1 0.0031 0.0031 0.0041
Entamoeba histolytica 60S ribosomal protein L19, putative 0.0028 0.002 0.0027
Leishmania major heat shock protein 83-1 0.0082 0.0219 0.0812
Echinococcus granulosus peregrin 0.0096 0.0267 0.0349
Onchocerca volvulus 0.0024 0.0008 0.0008
Echinococcus multilocularis cyclin dependent kinase 5 0.0059 0.0134 0.0175
Trichomonas vaginalis phosphofructokinase, putative 0.0121 0.0361 0.0824
Leishmania major 4-coumarate:coa ligase-like protein 0.0051 0.0107 0.0392
Echinococcus granulosus chromobox protein 2 0.0026 0.0014 0.0019
Loa Loa (eye worm) hypothetical protein 0.0038 0.0059 0.0192
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.0225 0.0838
Echinococcus multilocularis roundabout 2 0.0042 0.0071 0.0093
Entamoeba histolytica 60S ribosomal protein L19, putative 0.0028 0.002 0.0027
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0014 0.0014
Brugia malayi glutathione reductase 0.004 0.0066 0.0091
Schistosoma mansoni DNA topoisomerase type I 0.02 0.0647 0.0848
Toxoplasma gondii hypothetical protein 0.0052 0.0108 0.0397
Brugia malayi CXXC zinc finger family protein 0.0064 0.0153 0.0211
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0152 0.0471 0.1757
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0078 0.0202 0.0265
Loa Loa (eye worm) histone methyltransferase 0.0024 0.0009 0.0028
Brugia malayi AMP-binding enzyme family protein 0.0051 0.0107 0.0147
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.0335 0.1248
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0059 0.0134 0.0495
Schistosoma mansoni intermediate filament proteins 0.0061 0.0141 0.0185
Echinococcus granulosus microtubule associated protein 2 0.2124 0.7635 1
Trypanosoma cruzi cruzipain precursor, putative 0.0093 0.0257 0.0955
Toxoplasma gondii histone lysine demethylase JMJD6a 0.003 0.0029 0.0103
Onchocerca volvulus 0.0055 0.0121 0.0121
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0046 0.0087 0.0183
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0014 0.0014
Schistosoma mansoni bromodomain containing protein 0.0065 0.0155 0.0203
Echinococcus granulosus metabotropic glutamate receptor 2 0.0028 0.0023 0.003
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.0225 0.0838
Toxoplasma gondii NAC domain-containing protein 0.0034 0.0043 0.0153
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0046 0.0087 0.0087
Leishmania major 4-coumarate:coa ligase-like protein 0.0051 0.0107 0.0392
Loa Loa (eye worm) hypothetical protein 0.0217 0.0706 0.2287
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0031 0.0034 0.0045
Entamoeba histolytica PH domain containing protein kinase, putative 0.0046 0.0086 0.0182
Echinococcus granulosus neuropeptide receptor A26 0.1131 0.4029 0.5277
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0051 0.0107 0.024
Schistosoma mansoni myelin transcription factor 1 myt1 0.0057 0.0127 0.0167
Loa Loa (eye worm) jmjC domain-containing protein 0.003 0.0029 0.0095
Trypanosoma brucei DNA topoisomerase IB, large subunit 0.015 0.0464 0.1733
Brugia malayi hypothetical protein 0.0031 0.0034 0.0047
Brugia malayi PHD-finger family protein 0.0028 0.0021 0.0028
Trypanosoma cruzi heat shock protein 85, putative 0.0082 0.0219 0.0812
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0047 0.009 0.029
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0588 0.2054 1
Brugia malayi Valyl-tRNA synthetase 0.0026 0.0014 0.002
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1203 0.4289 1
Trypanosoma brucei heat shock protein 84, putative 0.0046 0.0087 0.0319
Onchocerca volvulus Huntingtin homolog 0.0247 0.0817 0.0817
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0031 0.0109
Leishmania major cathepsin L-like protease 0.0024 0.0008 0.0025
Echinococcus granulosus ecdysone induced protein 78C 0.0047 0.009 0.0117
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0039 0.0072
Plasmodium falciparum heterochromatin protein 1 0.0026 0.0014 0.0048
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0033 0.0039 0.4946
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0056 0.0122 0.016
Trypanosoma cruzi Heat shock protein 83, putative 0.0082 0.0219 0.0812
Leishmania major 4-coumarate:coa ligase-like protein 0.0051 0.0107 0.0392
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0047 0.009 0.0124
Brugia malayi MH1 domain containing protein 0.0025 0.0009 0.0013
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0026 0.0014 0.0048
Onchocerca volvulus 0.0024 0.0008 0.0008
Plasmodium falciparum basic transcription factor 3b, putative 0.0034 0.0043 0.0153
Leishmania major protein kinase A catalytic subunit isoform 1 0.0046 0.0086 0.0316
Schistosoma mansoni steroid hormone receptor ad4bp 0.0047 0.009 0.0117
Trypanosoma cruzi cdc2-related kinase 1 0.0059 0.0134 0.0494
Giardia lamblia Heat shock protein HSP 90-alpha 0.0082 0.0219 0.0466
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0126 0.0379 0.0496
Brugia malayi PHD-finger family protein 0.0036 0.0051 0.007
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0042 0.0072 0.0264
Loa Loa (eye worm) hypothetical protein 0.0428 0.1474 0.4772
Trypanosoma brucei heat shock protein, putative 0.0082 0.0219 0.0813
Leishmania major heat shock protein 83-1 0.0082 0.0219 0.0812
Brugia malayi nuclear hormone receptor 0.0047 0.009 0.0124
Loa Loa (eye worm) hypothetical protein 0.0051 0.0107 0.0345
Echinococcus multilocularis ribosomal protein L19 0.0028 0.002 0.0026
Trypanosoma cruzi DNA polymerase eta, putative 0.0042 0.0072 0.0263
Trypanosoma brucei heat shock protein, putative 0.0082 0.0219 0.0813
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0258 0.0337
Schistosoma mansoni heat shock protein 0.0082 0.0219 0.0287
Entamoeba histolytica ras-1, putative 0.0061 0.0141 0.031
Toxoplasma gondii 6-phosphofructokinase 0.0033 0.0039 0.014
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.0225 0.0838
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0321 0.1084 0.4052
Trypanosoma brucei heat shock protein, putative 0.0082 0.0219 0.0813
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0335 0.0763
Trichomonas vaginalis CAMK family protein kinase 0.0061 0.0142 0.0311
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0033 0.0039 0.4946
Echinococcus multilocularis cysteine protease 0.0024 0.0008 0.0011
Plasmodium vivax basic transcription factor 3b, putative 0.0034 0.0043 0.0153
Trichomonas vaginalis CAMK family protein kinase 0.0061 0.0142 0.0311
Echinococcus granulosus JmjC domain containing protein 4 0.003 0.0029 0.0038
Brugia malayi Immunoglobulin I-set domain containing protein 0.0136 0.0415 0.0572
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.003 0.0029 0.0103
Brugia malayi Niemann-Pick C1 protein precursor 0.0062 0.0147 0.0203
Loa Loa (eye worm) AGC/PKA protein kinase 0.0046 0.0086 0.0279
Trichomonas vaginalis conserved hypothetical protein 0.0089 0.0244 0.055
Trypanosoma cruzi casein kinase, putative 0.0624 0.2187 0.8182
Loa Loa (eye worm) TAR-binding protein 0.0206 0.0669 0.2164
Echinococcus multilocularis casein kinase I delta 0.0624 0.2187 0.2865
Trypanosoma cruzi DNA polymerase eta, putative 0.008 0.0212 0.0785
Echinococcus multilocularis heat shock protein 90 0.0082 0.0219 0.0287
Echinococcus granulosus jumonji domain containing protein 0.013 0.0391 0.0512
Trypanosoma cruzi heat shock protein 90, putative 0.0082 0.0219 0.0812
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0305 0.1029 0.1348
Onchocerca volvulus 0.0134 0.0406 0.0406
Mycobacterium ulcerans hypothetical protein 0.0169 0.0533 0.2377
Loa Loa (eye worm) fibroinase 0.0024 0.0008 0.0027
Loa Loa (eye worm) heat shock protein 75 0.0046 0.0087 0.0281
Brugia malayi beta-NAC-like protein 0.0034 0.0043 0.0059
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0031 0.0031 0.0043
Loa Loa (eye worm) hypothetical protein 0.0026 0.0014 0.0047
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0085 0.0312
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0047 0.009 0.0117
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0047 0.009 0.0124
Brugia malayi Pre-SET motif family protein 0.0872 0.3089 0.4263
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.003 0.0029 0.0103
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0069 0.0172 0.0225
Echinococcus granulosus heat shock protein 90 0.0082 0.0219 0.0287
Trypanosoma brucei cyclin 2 0.003 0.003 0.0107
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.0335 0.1248
Loa Loa (eye worm) hypothetical protein 0.0038 0.0059 0.0192
Leishmania major telomerase reverse transcriptase, putative 0.0758 0.2673 1
Leishmania major protein kinase A catalytic subunit 0.0046 0.0086 0.0316
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0041 0.0067 0.0137
Echinococcus multilocularis casein kinase I alpha 0.0624 0.2187 0.2865
Schistosoma mansoni aldehyde dehydrogenase 0.0047 0.0092 0.012
Trypanosoma cruzi 60S ribosomal protein L19, putative 0.0028 0.002 0.0068
Echinococcus granulosus expressed protein 0.0417 0.1434 0.1879
Onchocerca volvulus 0.007 0.0174 0.0174
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0086 0.0316
Trypanosoma brucei heat shock protein, putative 0.0082 0.0219 0.0813
Trichomonas vaginalis penicillin-binding protein, putative 0.0054 0.0118 0.0255
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0024 0.0009 0.0011
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0046 0.0086 0.0317
Loa Loa (eye worm) hypothetical protein 0.0046 0.0086 0.0278
Trichomonas vaginalis esterase, putative 0.0054 0.0118 0.0255
Schistosoma mansoni protein kinase 0.0624 0.2187 0.2865
Trypanosoma cruzi hypothetical protein, conserved 0.0054 0.0118 0.0433
Schistosoma mansoni thyroid hormone receptor 0.0047 0.009 0.0117
Toxoplasma gondii ABC1 family protein 0.0054 0.0118 0.0434
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0068 0.0168 0.022
Brugia malayi hypothetical protein 0.0025 0.001 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0043 0.008
Schistosoma mansoni hypothetical protein 0.0069 0.0169 0.0221
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0335 0.0763
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0092 0.0253 0.1003
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0085 0.0312
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0024 0.0008 0.0011
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0031 0.0034 0.0045
Echinococcus granulosus tar DNA binding protein 0.0206 0.0669 0.0876
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.0335 0.0335
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0026 0.0014 0.0019
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0092 0.0253 0.1003
Entamoeba histolytica hypothetical protein 0.0026 0.0014 0.0014
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.024 0.0792 0.2564
Schistosoma mansoni 6-phosphofructokinase 0.0121 0.0361 0.0473
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0047 0.009 0.0117
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1203 0.4289 1
Schistosoma mansoni hypothetical protein 0.0913 0.3237 0.4239
Mycobacterium ulcerans heat shock protein 90 0.0072 0.0183 0.0622
Toxoplasma gondii phosphofructokinase PFKII 0.0033 0.0039 0.014
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0072 0.0183 0.0678
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0047 0.009 0.0117
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.0335 0.0439
Trichomonas vaginalis chromobox protein, putative 0.0096 0.0268 0.0607
Echinococcus granulosus cyclin dependent kinase 5 0.0059 0.0134 0.0175
Echinococcus granulosus tm gpcr rhodopsin 0.0642 0.2253 0.2951
Loa Loa (eye worm) latrophilin receptor protein 2 0.0069 0.0169 0.0546
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0047 0.009 0.009
Mycobacterium tuberculosis Conserved hypothetical protein 0.0169 0.0533 0.2404
Loa Loa (eye worm) Ras protein let-60 0.0061 0.0141 0.0457
Brugia malayi Latrophilin receptor protein 2 0.0069 0.0169 0.0233
Giardia lamblia DINP protein human, muc B family 0.0063 0.0148 0.03
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0093 0.0259 0.0339
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0024 0.0009 0.0011
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.0335 0.1248
Echinococcus multilocularis casein kinase I alpha 0.0624 0.2187 0.2865
Entamoeba histolytica hypothetical protein 0.0026 0.0014 0.0014
Echinococcus granulosus Niemann Pick C1 protein 0.0089 0.0244 0.032
Loa Loa (eye worm) hypothetical protein 0.0054 0.0118 0.038
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0009 0.003
Leishmania major hypothetical protein, conserved 0.0054 0.0118 0.0433
Loa Loa (eye worm) hypothetical protein 0.0047 0.009 0.029
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0012 0.0016
Mycobacterium ulcerans acyl-CoA synthetase 0.0051 0.0107 0.024
Schistosoma mansoni tar DNA-binding protein 0.0206 0.0669 0.0876
Brugia malayi Ras-related protein R-Ras2 0.0061 0.0141 0.0195
Onchocerca volvulus 0.0024 0.0008 0.0008
Trichomonas vaginalis GTP-binding protein rit, putative 0.0061 0.0141 0.031
Brugia malayi Associated with TFs and helicases family protein 0.0026 0.0014 0.002
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0047 0.009 0.0117
Echinococcus multilocularis protection of telomeres protein 1 0.0538 0.1873 0.2454
Trypanosoma cruzi 60S ribosomal protein L19, putative 0.0028 0.002 0.0068
Mycobacterium ulcerans esterase/lipase LipP 0.0054 0.0118 0.0295
Giardia lamblia Fructose-bisphosphate aldolase 0.1203 0.4289 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0073 0.0185 0.0685
Leishmania major cathepsin L-like protease 0.0024 0.0008 0.0025
Echinococcus granulosus lamin dm0 0.0061 0.0141 0.0185
Entamoeba histolytica heat shock protein 90, putative 0.0082 0.0219 0.0492
Plasmodium vivax telomerase reverse transcriptase, putative 0.0758 0.2673 1
Brugia malayi Fibronectin type III domain containing protein 0.0031 0.0034 0.0047
Leishmania major cathepsin L-like protease 0.0093 0.0257 0.0955
Leishmania major ATP-dependent phosphofructokinase 0.0121 0.0361 0.1345
Toxoplasma gondii ribosomal protein RPL19 0.0028 0.002 0.0068
Brugia malayi hypothetical protein 0.0428 0.1474 0.2034
Echinococcus granulosus survival motor neuron protein 1 0.0374 0.128 0.1676
Echinococcus multilocularis chromobox protein 1 0.0159 0.0497 0.0652
Entamoeba histolytica casein kinase 1, putative 0.0624 0.2187 0.509
Brugia malayi casein kinase I 0.0624 0.2187 0.3018
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0025 0.001 0.0031
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0024 0.0008 0.0027
Loa Loa (eye worm) hypothetical protein 0.0173 0.0549 0.1777
Loa Loa (eye worm) hypothetical protein 0.0036 0.0051 0.0164
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0041 0.0067 0.0137
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0031
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0038 0.0059 0.0038
Brugia malayi phosphofructokinase 0.0121 0.0361 0.0498
Schistosoma mansoni lamin 0.0061 0.0141 0.0185
Giardia lamblia Kinase, CK1 Casein kinase 0.0624 0.2187 0.5077
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0093 0.0257 0.0956
Brugia malayi Cathepsin L-like precursor 0.0024 0.0008 0.0012
Brugia malayi jmjC domain containing protein 0.003 0.0029 0.004
Brugia malayi 60S ribosomal protein L19 0.0028 0.002 0.0027
Schistosoma mansoni tar DNA-binding protein 0.0206 0.0669 0.0876
Echinococcus multilocularis musashi 0.0061 0.0141 0.0185
Echinococcus granulosus cyclin dependent kinase 0.0059 0.0134 0.0175
Echinococcus granulosus casein kinase I alpha 0.0624 0.2187 0.2865
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0335 0.0763
Trichomonas vaginalis set domain proteins, putative 0.0993 0.3526 0.8217
Entamoeba histolytica Ras family GTPase 0.0061 0.0141 0.031
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.012 0.0357 0.0468
Trichomonas vaginalis D-aminoacylase, putative 0.0054 0.0118 0.0255
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0152 0.0471 0.1756
Mycobacterium tuberculosis Probable lipase LipE 0.0054 0.0118 0.0328
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0032 0.0034 0.0045
Echinococcus granulosus sterol regulatory element binding protein 0.0027 0.0017 0.0023
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0039 0.014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0047 0.009 0.029
Echinococcus granulosus expressed conserved protein 0.0059 0.0133 0.0174
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0134 0.0293
Trypanosoma cruzi DNA polymerase kappa, putative 0.0084 0.0225 0.0837
Leishmania major basic transcription factor 3a, putative 0.0034 0.0043 0.0153
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0321 0.1084 0.4052
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.003 0.0031 0.0109
Echinococcus multilocularis endoplasmin 0.0072 0.0183 0.0239
Schistosoma mansoni cpg binding protein 0.007 0.0173 0.0226
Toxoplasma gondii cyclin2 related protein 0.003 0.003 0.0107
Loa Loa (eye worm) hypothetical protein 0.0031 0.0034 0.0111
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0034 0.0043 0.008
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0121 0.0361 0.1345
Echinococcus multilocularis dna polymerase eta 0.008 0.0212 0.0277
Schistosoma mansoni serine/threonine protein kinase 0.0143 0.0439 0.0575
Echinococcus multilocularis Smad4 0.0025 0.0009 0.0012
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0258 0.0337
Mycobacterium tuberculosis Conserved protein 0.0054 0.0118 0.0328
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0031 0.0031 0.01
Echinococcus granulosus chromobox protein 1 0.0159 0.0497 0.0652
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0054 0.0118 0.038
Echinococcus granulosus cyclin dependent kinase 1 0.0059 0.0134 0.0175
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0588 0.2054 1
Brugia malayi Cathepsin L-like precursor 0.0024 0.0008 0.0012
Echinococcus multilocularis thyroid hormone receptor alpha 0.0047 0.009 0.0117
Schistosoma mansoni phosphatidylserine receptor 0.003 0.0029 0.0038
Loa Loa (eye worm) hypothetical protein 0.0031 0.0034 0.0111
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0033 0.0039 0.0072
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0047 0.009 0.0124
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0121 0.0361 0.1345
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0093 0.0257 0.0956
Echinococcus multilocularis jumonji domain containing 1A 0.003 0.0029 0.0038
Brugia malayi Protein cec-1. 0.0026 0.0014 0.002
Loa Loa (eye worm) CHromoDomain protein family member 0.0032 0.0034 0.0111
Leishmania major 60S ribosomal protein L19, putative 0.0028 0.002 0.0068
Toxoplasma gondii histone lysine methyltransferase SET1 0.0128 0.0386 0.1439
Echinococcus granulosus tumor protein p63 0.0377 0.1291 0.1691
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0055 0.0119 0.044
Plasmodium falciparum casein kinase 1 0.0624 0.2187 0.8182
Loa Loa (eye worm) hypothetical protein 0.0029 0.0027 0.0086
Trichomonas vaginalis ral, putative 0.0061 0.0141 0.031
Echinococcus multilocularis Immunoglobulin 0.0031 0.0034 0.0045
Loa Loa (eye worm) glutamate receptor 0.0034 0.0043 0.0139
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0051 0.0107 0.0274
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0024 0.0008 0.0025
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0335 0.0763
Plasmodium falciparum cyclin, putative 0.003 0.003 0.0107
Schistosoma mansoni hypothetical protein 0.0069 0.0169 0.0221
Leishmania major 60S ribosomal protein L19, putative 0.0028 0.002 0.0068
Schistosoma mansoni DNA topoisomerase type I 0.015 0.0464 0.0608
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0039 0.0072
Trypanosoma brucei telomerase reverse transcriptase 0.0758 0.2673 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0041 0.0068 0.0089
Echinococcus granulosus PHD finger protein rhinoceros 0.0093 0.0259 0.0339
Trichomonas vaginalis AGC family protein kinase 0.0046 0.0086 0.0182
Brugia malayi CHD4 protein 0.0032 0.0034 0.0047
Entamoeba histolytica phosphofructokinase, putative 0.0121 0.0361 0.0824
Schistosoma mansoni chromobox protein 0.0026 0.0014 0.0019
Trypanosoma brucei heat shock protein 90, putative 0.0082 0.0219 0.0813
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0047 0.009 0.029
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0348 0.1183 0.5647
Schistosoma mansoni jumonji/arid domain-containing protein 0.0118 0.035 0.0458
Loa Loa (eye worm) hypothetical protein 0.0038 0.0059 0.0191
Brugia malayi MH2 domain containing protein 0.0025 0.0009 0.0013
Brugia malayi jmjC domain containing protein 0.003 0.0029 0.004
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0039 0.014
Schistosoma mansoni protein phosphatase 2C 0.003 0.0029 0.0038
Schistosoma mansoni DNA topoisomerase type I 0.015 0.0464 0.0608
Leishmania major cathepsin L-like protease 0.0093 0.0257 0.0955
Echinococcus multilocularis jumonji domain containing protein 0.013 0.0391 0.0512
Trypanosoma brucei heat shock protein, putative 0.0082 0.0219 0.0813
Brugia malayi MH2 domain containing protein 0.0025 0.0009 0.0013
Trichomonas vaginalis hypothetical protein 0.0026 0.0014 0.0014
Brugia malayi steroid hormone receptor 0.0047 0.009 0.0124
Onchocerca volvulus 0.0026 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0031 0.0034 0.0111
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.0225 0.0838
Schistosoma mansoni cpg binding protein 0.0064 0.0153 0.02
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0033 0.0039 0.0045
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0026 0.0014 0.0019
Echinococcus granulosus Niemann Pick C1 protein 0.0062 0.0147 0.0192
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0029 0.0027 0.0035
Trichomonas vaginalis 60S ribosomal protein L19, putative 0.0028 0.002 0.0027
Trichomonas vaginalis heat shock protein, putative 0.0068 0.0168 0.0374
Trypanosoma cruzi heat shock protein 85, putative 0.0082 0.0219 0.0812
Toxoplasma gondii DNA topoisomerase I, putative 0.02 0.0647 0.2417
Echinococcus multilocularis heat shock protein 0.0082 0.0219 0.0287
Loa Loa (eye worm) hypothetical protein 0.0046 0.0086 0.0279
Toxoplasma gondii AGC kinase 0.0046 0.0086 0.0317
Trypanosoma brucei trypanothione reductase 0.004 0.0066 0.024
Brugia malayi AMP-binding enzyme family protein 0.0051 0.0107 0.0147
Trypanosoma cruzi DNA topoisomerase IB, large subunit, putative 0.015 0.0464 0.1732
Loa Loa (eye worm) jmjC domain-containing protein 0.003 0.0029 0.0095
Leishmania major DNA polymerase eta, putative 0.0042 0.0072 0.0263
Loa Loa (eye worm) cytochrome P450 family protein 0.0042 0.0073 0.0236
Plasmodium vivax endoplasmin, putative 0.0082 0.0219 0.0813
Toxoplasma gondii AGC kinase 0.0046 0.0086 0.0317
Leishmania major trypanothione reductase 0.004 0.0066 0.0239
Echinococcus multilocularis chromobox protein 2 0.0026 0.0014 0.0019
Loa Loa (eye worm) hypothetical protein 0.0428 0.1474 0.4772
Plasmodium falciparum endoplasmin, putative 0.0056 0.0123 0.0454
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0615 0.2154 0.8058
Echinococcus granulosus protection of telomeres protein 1 0.0538 0.1873 0.2454
Echinococcus granulosus casein kinase i 0.0624 0.2187 0.2865
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0126 0.0379 0.0496
Loa Loa (eye worm) hypothetical protein 0.0026 0.0014 0.0047
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0258 0.0337
Leishmania major DNA polymerase eta, putative 0.008 0.0212 0.0785
Schistosoma mansoni cell adhesion molecule 0.0038 0.0059 0.0077
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.003 0.0031 0.0109
Mycobacterium tuberculosis Conserved protein 0.0054 0.0118 0.0328
Trypanosoma brucei transcription factor BTF3, putative 0.0034 0.0043 0.0153
Echinococcus multilocularis cathepsin L cysteine protease 0.0024 0.0008 0.0011
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0069 0.0169 0.0221
Echinococcus granulosus cathepsin l1 0.0024 0.0008 0.0011
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0046 0.0087 0.0114
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0047 0.009 0.0124
Echinococcus multilocularis smad 0.0025 0.0009 0.0012
Schistosoma mansoni tar DNA-binding protein 0.0206 0.0669 0.0876
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0069 0.0172 0.0225
Schistosoma mansoni 60S ribosomal protein L19 0.0028 0.002 0.0026
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0047 0.009 0.0117
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0206 0.0669 0.2164
Brugia malayi Heterochromatin protein 1 0.0159 0.0497 0.0687
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0042 0.0071 0.0093
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0031 0.004
Echinococcus multilocularis lamin 0.0061 0.0141 0.0185
Toxoplasma gondii Hsp90 domain-containing protein 0.0196 0.0633 0.2365
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0033 0.0039 0.0072
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0076 0.0197 0.0272
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0136 0.0415 0.1342
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0102 0.029 0.1188
Brugia malayi RNA, U transporter 1 0.0064 0.0152 0.021
Entamoeba histolytica heat shock protein 90, putative 0.0082 0.0219 0.0492
Leishmania major heat shock protein 83-1 0.0082 0.0219 0.0812
Loa Loa (eye worm) hypothetical protein 0.0025 0.001 0.0031
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0046 0.0086 0.0113
Echinococcus granulosus zinc finger protein 0.0023 0.0002 0.0002
Loa Loa (eye worm) endoplasmin 0.0082 0.0219 0.0708
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0043 0.008
Trypanosoma brucei Heat shock protein 83, putative 0.0082 0.0219 0.0813
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.0225 0.0838
Loa Loa (eye worm) hypothetical protein 0.0042 0.0071 0.0229
Echinococcus multilocularis expressed conserved protein 0.0059 0.0133 0.0174
Trypanosoma cruzi casein kinase, putative 0.0624 0.2187 0.8182
Echinococcus granulosus geminin 0.0278 0.093 0.1219
Trichomonas vaginalis heat shock protein, putative 0.0072 0.0183 0.0407
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0426 0.1466 0.4746
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0335 0.0763
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0217 0.0706 0.2287
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0014 0.0014
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0084 0.0225 0.0507
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0046 0.0086 0.0317
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0046 0.0086 0.0113
Mycobacterium tuberculosis Conserved protein 0.0054 0.0118 0.0328
Toxoplasma gondii cathepsin CPL 0.0024 0.0008 0.0025
Loa Loa (eye worm) intermediate filament protein 0.0061 0.0141 0.0457
Trypanosoma cruzi heat shock protein 90, putative 0.004 0.0066 0.0242
Plasmodium vivax acyl-CoA synthetase, putative 0.0038 0.0059 0.0216
Brugia malayi hypothetical protein 0.0173 0.0549 0.0758
Trypanosoma cruzi heat shock protein, putative 0.0046 0.0087 0.0319
Loa Loa (eye worm) hypothetical protein 0.0026 0.0014 0.0047
Treponema pallidum heat shock protein 90 0.0072 0.0183 0.0338
Schistosoma mansoni hypothetical protein 0.003 0.0031 0.004
Brugia malayi intermediate filament protein 0.0061 0.0141 0.0195
Echinococcus granulosus ras gtpase 0.0061 0.0141 0.0185
Brugia malayi ecdysteroid receptor 0.0047 0.009 0.0124
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0046 0.006
Onchocerca volvulus Tyrosine kinase homolog 0.0101 0.0287 0.0287
Loa Loa (eye worm) hypothetical protein 0.0093 0.0259 0.0837
Schistosoma mansoni hypothetical protein 0.0106 0.0305 0.04
Leishmania major heat shock protein 83-1 0.0082 0.0219 0.0812
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0172 0.0637
Brugia malayi M-phase phosphoprotein, mpp8 0.0026 0.0014 0.002
Echinococcus granulosus jumonji domain containing 1A 0.003 0.0029 0.0038
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0032 0.0034 0.0045
Brugia malayi AMP-binding enzyme family protein 0.0051 0.0107 0.0147
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0046 0.0086 0.0317
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0047 0.009 0.0124
Leishmania major cathepsin L-like protease 0.0024 0.0008 0.0025
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0041 0.0067 0.0137
Plasmodium vivax glutathione reductase, putative 0.004 0.0066 0.024
Loa Loa (eye worm) hypothetical protein 0.0033 0.0039 0.0127
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0043 0.0153
Mycobacterium tuberculosis Probable lipase LipD 0.0054 0.0118 0.0328
Entamoeba histolytica cell division protein kinase 2, putative 0.0059 0.0134 0.0293
Leishmania major heat shock protein 83-1 0.0082 0.0219 0.0812
Brugia malayi MH2 domain containing protein 0.0362 0.1233 0.1702
Loa Loa (eye worm) steroid hormone receptor 0.0047 0.009 0.029
Loa Loa (eye worm) hypothetical protein 0.0026 0.0014 0.0047
Echinococcus granulosus dna polymerase kappa 0.0084 0.0225 0.0295
Loa Loa (eye worm) hypothetical protein 0.0047 0.009 0.029
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0069 0.0172 0.0225
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.004 0.0066 0.007
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0078 0.0202 0.0265
Trichomonas vaginalis heat shock protein, putative 0.0072 0.0183 0.0407
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0148 0.0547
Trypanosoma cruzi heat shock protein 90, putative 0.0068 0.0168 0.0623
Echinococcus multilocularis thioredoxin glutathione reductase 0.0041 0.0068 0.0089
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0051 0.0107 0.024
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.0258 0.0834
Echinococcus multilocularis cyclin dependent kinase 1 0.0059 0.0134 0.0175
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.0225 0.0838
Echinococcus multilocularis histone acetyltransferase MYST2 0.0057 0.0127 0.0167
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0069 0.0169 0.0221
Echinococcus multilocularis lamin dm0 0.0061 0.0141 0.0185
Loa Loa (eye worm) hypothetical protein 0.0047 0.009 0.029
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0043 0.0153
Plasmodium falciparum heat shock protein 90, putative 0.0042 0.0072 0.0265
Trypanosoma cruzi trypanothione reductase, putative 0.004 0.0066 0.0239
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0051 0.0107 0.024
Brugia malayi hypothetical protein 0.0083 0.0222 0.0306
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0152 0.0471 0.1756
Brugia malayi jmjC domain containing protein 0.0118 0.035 0.0483
Echinococcus granulosus neuropeptide s receptor 0.1131 0.4029 0.5277
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0059 0.0134 0.0494
Loa Loa (eye worm) hypothetical protein 0.0031 0.0034 0.0111
Loa Loa (eye worm) hypothetical protein 0.0054 0.0118 0.038
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0141 0.0431 0.0564
Brugia malayi F/Y-rich N-terminus family protein 0.0056 0.0125 0.0173
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0134 0.0175
Mycobacterium tuberculosis Conserved hypothetical protein 0.0056 0.0122 0.0351
Schistosoma mansoni aldehyde dehydrogenase 0.0047 0.0092 0.012
Loa Loa (eye worm) hypothetical protein 0.008 0.0212 0.0685
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0045 0.0084 0.0307
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0046 0.0086 0.0317
Mycobacterium ulcerans aldehyde dehydrogenase 0.0047 0.0092 0.0167
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0086 0.0316
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0046 0.0086 0.0113
Echinococcus multilocularis microtubule associated protein 2 0.2124 0.7635 1
Plasmodium vivax heat shock protein 86, putative 0.0082 0.0219 0.0813
Schistosoma mansoni hypothetical protein 0.0308 0.1038 0.1359
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.003 0.0029 0.0103
Schistosoma mansoni heat shock protein 0.0046 0.0087 0.0114
Echinococcus granulosus smad 0.0025 0.0009 0.0012
Brugia malayi jmjC domain containing protein 0.003 0.0029 0.004
Leishmania major cathepsin L-like protease 0.0024 0.0008 0.0025
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0258 0.0337
Schistosoma mansoni smad1 5 8 and 0.0025 0.0009 0.0012
Trypanosoma cruzi CYC2-like cyclin 4, putative 0.003 0.003 0.0106
Schistosoma mansoni cpg binding protein 0.007 0.0173 0.0226
Trichomonas vaginalis D-aminoacylase, putative 0.0054 0.0118 0.0255
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0107 0.0274
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0046 0.0086 0.0317
Echinococcus granulosus transcription factor Dp 1 0.004 0.0066 0.0086
Plasmodium vivax 60S ribosomal protein L19, putative 0.0028 0.002 0.0068
Mycobacterium leprae Probable lipase LipE 0.0054 0.0118 0.0056
Loa Loa (eye worm) 6-phosphofructokinase 0.0121 0.0361 0.1168
Plasmodium falciparum 60S ribosomal protein L19 0.0028 0.002 0.0068
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0143 0.0439 0.0575
Plasmodium falciparum topoisomerase I 0.02 0.0647 0.2417
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0063 0.015 0.0197
Echinococcus multilocularis heat shock protein 90 0.0068 0.0168 0.022
Entamoeba histolytica acyl-coA synthetase, putative 0.0051 0.0107 0.0229
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0031 0.0034 0.0045
Schistosoma mansoni chromobox protein 0.0159 0.0497 0.0652
Brugia malayi Nuclear hormone receptor-like 1 0.0047 0.009 0.0124
Trichomonas vaginalis endoplasmin, putative 0.0056 0.0123 0.0268
Schistosoma mansoni terminal deoxycytidyl transferase 0.0056 0.0122 0.016
Mycobacterium ulcerans aldehyde dehydrogenase 0.0047 0.0092 0.0167
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0143 0.0439 0.0575
Echinococcus granulosus heat shock protein 90 0.0068 0.0168 0.022
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0047 0.009 0.0117
Echinococcus multilocularis tumor protein p63 0.0377 0.1291 0.1691
Echinococcus multilocularis Niemann Pick C1 protein 0.0089 0.0244 0.032
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0143 0.0187
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0063 0.0148 0.0479
Trypanosoma cruzi casein kinase, putative 0.0624 0.2187 0.8182
Echinococcus granulosus snurportin 1 0.024 0.0792 0.1037
Schistosoma mansoni aryl hydrocarbon receptor 0.0052 0.0107 0.0141
Loa Loa (eye worm) jmjC domain-containing protein 0.0192 0.0619 0.2004
Brugia malayi Cytochrome P450 family protein 0.0042 0.0073 0.0101
Schistosoma mansoni jumonji/arid domain-containing protein 0.0118 0.035 0.0458
Trypanosoma brucei CYC2-like cyclin, putative 0.003 0.003 0.0107
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0152 0.0473 0.062
Leishmania major heat shock protein 83-1 0.0082 0.0219 0.0812
Schistosoma mansoni importin beta-1 0.0022 0.0002 0.0002
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.003 0.0031 0.0109
Leishmania major heat shock protein 83-1 0.0082 0.0219 0.0812
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0143 0.0187
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.0258 0.0355
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0039 0.006 0.0078
Brugia malayi hypothetical protein 0.0106 0.0305 0.0422
Trypanosoma brucei cdc2-related kinase 3 0.0059 0.0134 0.0495
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0046 0.006
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0069 0.0172 0.0237
Echinococcus multilocularis neuroglian 0.0035 0.0046 0.0061
Echinococcus granulosus chromobox protein 1 0.0159 0.0497 0.0652
Schistosoma mansoni patched 1 0.0027 0.0017 0.0023
Entamoeba histolytica Ras family GTPase 0.0061 0.0141 0.031
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0047 0.009 0.0117
Giardia lamblia Telomerase catalytic subunit 0.0758 0.2673 0.6214
Echinococcus granulosus cathepsin L cysteine proteinase 0.0024 0.0008 0.0011
Entamoeba histolytica PH domain containing protein kinase, putative 0.0046 0.0086 0.0182
Echinococcus multilocularis GPCR, family 2 0.0069 0.0169 0.0221
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0066 0.0086
Echinococcus granulosus lysine specific demethylase 5A 0.0118 0.035 0.0458
Leishmania major cathepsin L-like protease 0.0093 0.0257 0.0955
Schistosoma mansoni zinc finger protein 0.0023 0.0002 0.0002
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0068 0.0168 0.0544
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0039 0.014
Brugia malayi hypothetical protein 0.0247 0.0817 0.1128
Trypanosoma cruzi cdc2-related kinase 3 0.0059 0.0134 0.0494
Plasmodium vivax heat shock protein, putative 0.0196 0.0633 0.2365
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0009 0.003
Echinococcus multilocularis cathepsin L cysteine protease 0.0024 0.0008 0.0011
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0054 0.0118 0.0328
Brugia malayi hypoxia-induced factor 1 0.016 0.05 0.069
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0039 0.0072
Mycobacterium ulcerans hypothetical protein 0.0054 0.0118 0.0295
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1203 0.4289 1
Echinococcus granulosus heat shock protein 0.0082 0.0219 0.0287
Loa Loa (eye worm) 6-phosphofructokinase 0.0121 0.0361 0.1168
Brugia malayi Nuclear hormone receptor-like 1 0.0025 0.001 0.0013
Trypanosoma cruzi DNA polymerase kappa, putative 0.0084 0.0225 0.0837
Trypanosoma brucei polo-like protein kinase 0.0114 0.0335 0.1248
Brugia malayi PAS domain containing protein 0.0052 0.0107 0.0148
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0086 0.0113
Plasmodium vivax thioredoxin reductase, putative 0.004 0.0066 0.024
Trypanosoma brucei DNA polymerase IV, putative 0.0084 0.0225 0.0838
Brugia malayi Importin beta-1 subunit 0.0022 0.0002 0.0002
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0054 0.0118 0.0154
Entamoeba histolytica cell division protein kinase 2, putative 0.0059 0.0134 0.0293
Echinococcus granulosus endoplasmin 0.0072 0.0183 0.0239
Loa Loa (eye worm) beta-lactamase 0.0054 0.0118 0.038
Plasmodium falciparum telomerase reverse transcriptase 0.0758 0.2673 1
Plasmodium vivax protein kinase Crk2 0.0059 0.0134 0.0495
Loa Loa (eye worm) heat shock protein 90 0.0082 0.0219 0.0708
Entamoeba histolytica hypothetical protein 0.0083 0.0222 0.0498
Trypanosoma cruzi cysteine peptidase, putative 0.0093 0.0257 0.0955
Onchocerca volvulus 0.0615 0.2154 0.2154
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0054 0.0118 0.0328
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0149 0.0329
Loa Loa (eye worm) hypothetical protein 0.0026 0.0014 0.0047
Trichomonas vaginalis CK1 family protein kinase 0.0624 0.2187 0.509
Brugia malayi nuclear receptor NHR-88 0.0047 0.009 0.0124
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0014 0.0014
Brugia malayi CHE-14 protein 0.0027 0.0017 0.0024
Loa Loa (eye worm) MH2 domain-containing protein 0.0362 0.1233 0.3993
Mycobacterium ulcerans acyl-CoA synthetase 0.0051 0.0107 0.024
Echinococcus multilocularis casein kinase I alpha 0.0624 0.2187 0.2865
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0624 0.2187 0.8182
Trichomonas vaginalis CK1 family protein kinase 0.0624 0.2187 0.509
Loa Loa (eye worm) hypothetical protein 0.0028 0.0023 0.0073
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0047 0.0092 0.0337
Onchocerca volvulus 0.0024 0.0008 0.0008
Plasmodium vivax cyclin, putative 0.003 0.003 0.0107
Echinococcus granulosus roundabout 2 0.0042 0.0071 0.0093
Loa Loa (eye worm) hypothetical protein 0.0106 0.0305 0.0989
Mycobacterium ulcerans DNA polymerase IV 0.0084 0.0225 0.0836
Plasmodium vivax hypothetical protein, conserved 0.0093 0.0259 0.0962
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0624 0.2187 0.7081
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0047 0.009 0.029
Brugia malayi Bromodomain containing protein 0.0096 0.0267 0.0368
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0083 0.0222 0.029
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0059 0.0134 0.0494
Plasmodium falciparum phd finger protein, putative 0.0093 0.0259 0.0962
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0039 0.0072
Leishmania major heat shock protein, putative 0.0046 0.0087 0.0319
Schistosoma mansoni endoplasmin 0.0082 0.0219 0.0287
Plasmodium falciparum cysteine proteinase falcipain 3 0.0024 0.0008 0.0025
Giardia lamblia Kinase, CMGC CDK 0.0059 0.0134 0.0267
Echinococcus multilocularis transfer RNA-Lys 0.0038 0.0059 0.0077
Brugia malayi jmjC domain containing protein 0.0305 0.1029 0.142
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0046 0.0086 0.0113
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0031 0.004
Trypanosoma cruzi heat shock protein 85, putative 0.0068 0.0168 0.0623
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1203 0.4289 1
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0758 0.2673 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0121 0.0361 0.0757
Trypanosoma brucei DNA polymerase eta, putative 0.008 0.0212 0.0786
Echinococcus granulosus polycomb protein SCMH1 0.005 0.0102 0.0134
Schistosoma mansoni tar DNA-binding protein 0.0206 0.0669 0.0876
Brugia malayi Calcitonin receptor-like protein seb-1 0.0217 0.0706 0.0975
Brugia malayi Immunoglobulin I-set domain containing protein 0.0031 0.0034 0.0047
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0102 0.029 0.1188
Loa Loa (eye worm) hypothetical protein 0.005 0.0102 0.033
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0039 0.0071
Trichomonas vaginalis phosphofructokinase, putative 0.0121 0.0361 0.0824
Brugia malayi hypothetical protein 0.0374 0.128 0.1766
Loa Loa (eye worm) hypothetical protein 0.016 0.05 0.162
Loa Loa (eye worm) RNA binding protein 0.0206 0.0669 0.2164
Brugia malayi Steroid receptor seven-up type 2 0.0047 0.009 0.0124
Brugia malayi hypothetical protein 0.0106 0.0305 0.0422
Giardia lamblia Kinase, PLK 0.0114 0.0335 0.0738
Echinococcus multilocularis importin subunit beta 1 0.0022 0.0002 0.0002
Trypanosoma brucei heat shock protein, putative 0.0082 0.0219 0.0813
Loa Loa (eye worm) hypothetical protein 0.0039 0.0063 0.0203
Leishmania major DNA topoisomerase type IB small subunit 0.005 0.0103 0.0378
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0041 0.0067 0.0137
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0054 0.0118 0.0295
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.0225 0.0838
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0056 0.0122 0.016
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0034 0.0045 0.0162
Entamoeba histolytica phosphofructokinase, putative 0.0121 0.0361 0.0824
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0038 0.0059 0.0192
Schistosoma mansoni microtubule-associated protein tau 0.2124 0.7635 1
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0045 0.0162
Trichomonas vaginalis phosphofructokinase, putative 0.0121 0.0361 0.0824
Brugia malayi Hsp90 protein 0.0046 0.0087 0.012
Echinococcus granulosus transcription factor btf3 0.0034 0.0043 0.0056
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0872 0.3089 1
Schistosoma mansoni hypothetical protein 0.0026 0.0014 0.0018
Plasmodium vivax vivapain-2 0.0024 0.0008 0.0025
Brugia malayi Ras protein let-60 0.0061 0.0141 0.0195
Schistosoma mansoni cellular tumor antigen P53 0.0055 0.0121 0.0158
Brugia malayi mbt repeat family protein 0.005 0.0102 0.0141
Brugia malayi Smad1 0.0025 0.0009 0.0013
Echinococcus multilocularis Protein lozenge 0.0054 0.0115 0.015
Brugia malayi DNA topoisomerase I 0.02 0.0647 0.0893
Plasmodium vivax heterochromatin protein 1, putative 0.0026 0.0014 0.0048

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 1.4 nM Displacement of [125I]nociceptin from human NOP expressed in CHO cells ChEMBL. 19147350
Ki (binding) = 68 nM Displacement of [125I]diprenorphine from human KOP expressed in CHO cells ChEMBL. 19147350
Ki (binding) = 69 nM Displacement of [125I]diprenorphine from human MOP expressed in CHO cells ChEMBL. 19147350
Ki (binding) = 5016 nM Displacement of [125I]diprenorphine from human DOP expressed in CHO cells ChEMBL. 19147350

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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