Detailed information for compound 108431

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 700.731 | Formula: C37H38F2N6O6
  • H donors: 2 H acceptors: 6 LogP: 3.02 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: Fc1cc2c(=O)c(cn(c2cc1N1CCN(CC1)C/C=C/N1CCN(CC1)c1cc2n(cc(c(=O)c2cc1F)C(=O)O)C1CC1)C1CC1)C(=O)O
  • InChi: 1S/C37H38F2N6O6/c38-28-16-24-30(44(22-2-3-22)20-26(34(24)46)36(48)49)18-32(28)42-12-8-40(9-13-42)6-1-7-41-10-14-43(15-11-41)33-19-31-25(17-29(33)39)35(47)27(37(50)51)21-45(31)23-4-5-23/h1,6,16-23H,2-5,7-15H2,(H,48,49)(H,50,51)/b6-1+
  • InChiKey: SCOHDUANFDOJDY-LZCJLJQNSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0743 0.614 1
Entamoeba histolytica hypothetical protein 0.011 0.0831 0.29
Trypanosoma cruzi DNA polymerase kappa, putative 0.0014 0.003 0.0139
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0019 0.0068 0.0185
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0074 0.0178
Onchocerca volvulus 0.0023 0.0101 0.0283
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.007 0.05 0.2295
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0067 0.006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0019 0.0074 0.0151
Schistosoma mansoni hypothetical protein 0.011 0.0831 0.0831
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0019 0.0068 0.0573
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0013 0.0019 0.0046
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0058 0.0058
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0018 0.0067 0.0067
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0016 0.0044 0.0044
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0019 0.0068 0.0185
Entamoeba histolytica cysteine proteinase, putative 0.0012 0.0015 0.0051
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0018 0.0067 0.0307
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0081 0.0589 0.4955
Loa Loa (eye worm) hypothetical protein 0.0099 0.0738 0.1514
Trichomonas vaginalis glucosylceramidase, putative 0.0451 0.3687 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0423 0.0423
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0148 0.1156 0.1156
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.003 0.0139
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0063 0.044 0.3699
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0019 0.0068 0.0313
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0019 0.0068 0.027
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.003 0.0139
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.015 0.0687
Onchocerca volvulus Protein cereblon homolog 0.0353 0.2866 0.8029
Echinococcus granulosus beta LACTamase domain containing family member 0.0116 0.0887 0.0887
Loa Loa (eye worm) hypothetical protein 0.0437 0.357 0.7323
Loa Loa (eye worm) hypothetical protein 0.0018 0.0067 0.0137
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0019 0.0068 0.0068
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0177 0.0479
Loa Loa (eye worm) hypothetical protein 0.0213 0.1697 0.348
Brugia malayi prolyl oligopeptidase family protein 0.0028 0.015 0.0361
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0068 0.0313
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0101 0.076 0.076
Loa Loa (eye worm) hypothetical protein 0.0072 0.0518 0.1062
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0078 0.0564 0.0564
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0019 0.0068 0.0238
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0013 0.0019 0.0019
Toxoplasma gondii prolyl endopeptidase 0.0271 0.218 1
Schistosoma mansoni peroxidasin 0.0437 0.357 0.357
Schistosoma mansoni chromosome transmission fidelity factor 0.0011 0.00000023581 0.00000023581
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.006 0.0418 0.0635
Loa Loa (eye worm) hypothetical protein 0.0047 0.0306 0.0628
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0013 0.0019 0.0019
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.2526 0.685
Schistosoma mansoni hypothetical protein 0.0592 0.4875 0.4875
Loa Loa (eye worm) hypothetical protein 0.0013 0.0019 0.0039
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0074 0.0074
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0013 0.0019 0.0019
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.2526 0.685
Echinococcus granulosus acylamino acid releasing enzyme 0.0028 0.015 0.015
Onchocerca volvulus 0.0019 0.0074 0.0207
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0012 0.0015 0.004
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0071 0.0192
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.007 0.05 0.2295
Echinococcus granulosus muscleblind protein 0.0145 0.1128 0.1128
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0044 0.012
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0071 0.0325
Mycobacterium tuberculosis Probable lipase LipE 0.0116 0.0887 0.1402
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0045 0.0289 0.0784
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0008 0.0008
Brugia malayi beta-lactamase family protein 0.0116 0.0887 0.2135
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0034 0.0197 0.0273
Brugia malayi Cathepsin L-like precursor 0.0012 0.0015 0.0035
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0013 0.0019 0.0039
Plasmodium falciparum peptidase, putative 0.0028 0.015 0.0931
Trypanosoma brucei prolyl endopeptidase 0.0271 0.218 1
Brugia malayi TAR-binding protein 0.0065 0.0459 0.1106
Entamoeba histolytica acyl-coA synthetase, putative 0.0063 0.044 0.1534
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0078 0.0564 0.0564
Loa Loa (eye worm) hypothetical protein 0.0013 0.0019 0.0039
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0703 0.0703
Brugia malayi Cathepsin L-like precursor 0.0012 0.0015 0.0035
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0271 0.218 0.218
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0506 0.4152 0.8518
Loa Loa (eye worm) hypothetical protein 0.0437 0.357 0.7323
Echinococcus granulosus geminin 0.0552 0.4535 0.4535
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0019 0.0074 0.0178
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0019 0.0068 0.0062
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0019 0.0068 0.0062
Loa Loa (eye worm) hypothetical protein 0.0019 0.0074 0.0151
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0063 0.044 0.067
Mycobacterium leprae conserved hypothetical protein 0.0116 0.0887 0.7459
Entamoeba histolytica hypothetical protein 0.011 0.0831 0.29
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0047 0.0307 0.1407
Mycobacterium tuberculosis Probable oxidoreductase 0.007 0.05 0.0769
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0019 0.0068 0.0313
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0081 0.0589 1
Loa Loa (eye worm) hypothetical protein 0.0437 0.357 0.7323
Loa Loa (eye worm) hypothetical protein 0.0063 0.044 0.0902
Entamoeba histolytica hypothetical protein, conserved 0.0353 0.2866 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0303 0.1392
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0071 0.0325
Echinococcus multilocularis cathepsin L cysteine protease 0.0012 0.0015 0.0015
Mycobacterium ulcerans acyl-CoA synthetase 0.0063 0.044 0.3699
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0418 0.0418
Brugia malayi MH2 domain containing protein 0.0016 0.0048 0.0116
Trichomonas vaginalis glutamate synthase, putative 0.0019 0.0068 0.0185
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0018 0.0067 0.0563
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0206 0.0558
Chlamydia trachomatis thioredoxin reductase 0.0019 0.0068 0.1157
Brugia malayi Cation transporter family protein 0.0013 0.0019 0.0046
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0203 0.161 0.2586
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0071 0.0281
Loa Loa (eye worm) hypothetical protein 0.0271 0.218 0.4473
Brugia malayi Animal haem peroxidase family protein 0.0437 0.357 0.8598
Plasmodium falciparum glutathione reductase 0.007 0.05 0.3108
Loa Loa (eye worm) hypothetical protein 0.0437 0.357 0.7323
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.011 0.0831 0.0831
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0041 0.0254 0.1165
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0041 0.0254 0.0612
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0018 0.0067 0.0161
Toxoplasma gondii hypothetical protein 0.0028 0.0145 0.0666
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0018 0.0048
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0019 0.0074 0.0151
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0018 0.0067 0.0563
Onchocerca volvulus 0.0063 0.044 0.1232
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0081 0.0589 0.0589
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0019 0.0074 0.0178
Plasmodium vivax vivapain-2 0.0012 0.0015 0.0091
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0063 0.044 0.067
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0459 0.1106
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0019 0.0068 0.0062
Echinococcus multilocularis dna polymerase eta 0.0033 0.0187 0.0187
Leishmania major acetyl-CoA synthetase, putative 0.0018 0.0067 0.0241
Toxoplasma gondii target of rapamycin (TOR), putative 0.0035 0.0206 0.0943
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.011 0.0831 0.0831
Loa Loa (eye worm) hypothetical protein 0.0019 0.0074 0.0151
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0058 0.0058
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0116 0.0887 0.7459
Entamoeba histolytica hypothetical protein, conserved 0.0028 0.015 0.0523
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0013 0.0019 0.0019
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0018 0.0067 0.0563
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0028 0.0145 0.1222
Echinococcus granulosus glycine receptor subunit alpha 1 0.0013 0.0019 0.0019
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.007 0.05 0.2295
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0018 0.0067 0.0416
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0028 0.015 0.015
Onchocerca volvulus 0.0012 0.0015 0.0041
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0074 0.0074
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0015 0.004
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0423 0.0423
Entamoeba histolytica Ran family GTPase 0.0041 0.0254 0.0887
Leishmania major 4-coumarate:coa ligase-like protein 0.0063 0.044 0.1962
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.007 0.05 0.3108
Schistosoma mansoni nAChR subunit 0.0013 0.0019 0.0019
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0047 0.0306 0.52
Echinococcus granulosus prolyl endopeptidase 0.0271 0.218 0.218
Trypanosoma cruzi hypothetical protein, conserved 0.0116 0.0887 0.4067
Trichomonas vaginalis glucosylceramidase, putative 0.0451 0.3687 1
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0019 0.0068 0.0062
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0047 0.0307 0.1407
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0018 0.0067 0.0161
Trichomonas vaginalis glutathione reductase, putative 0.007 0.05 0.1357
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0047 0.0307 0.1407
Loa Loa (eye worm) hypothetical protein 0.0028 0.015 0.0307
Schistosoma mansoni ap endonuclease 0.0019 0.0071 0.0071
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0048 0.0048
Loa Loa (eye worm) fibroinase 0.0012 0.0015 0.003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0015 0.004
Brugia malayi glutathione reductase 0.0203 0.161 0.3878
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0012 0.0015 0.004
Echinococcus multilocularis glutamate synthase 0.0019 0.0068 0.0068
Mycobacterium tuberculosis Probable peptidase 0.0108 0.0814 0.1283
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0013 0.0019 0.0019
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0014 0.003 0.003
Echinococcus multilocularis protein patched 0.0043 0.027 0.027
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0048 0.0099
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0013 0.0019 0.0019
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0041 0.0254 0.1165
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.007 0.05 0.8496
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0028 0.015 0.015
Trypanosoma brucei prolyl oligopeptidase, putative 0.0108 0.0814 0.3734
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0019 0.0068 0.0573
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0019 0.0068 0.0185
Onchocerca volvulus 0.0012 0.0015 0.0041
Entamoeba histolytica hypothetical protein 0.0045 0.0289 0.1008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0015 0.004
Mycobacterium tuberculosis Probable esterase LipL 0.0116 0.0887 0.1402
Mycobacterium ulcerans hypothetical protein 0.0063 0.044 0.3699
Brugia malayi hypothetical protein 0.0131 0.1011 0.2434
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0703 0.0703
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0013 0.0019 0.0046
Brugia malayi Animal haem peroxidase family protein 0.0437 0.357 0.8598
Schistosoma mansoni steroid hormone receptor ad4bp 0.0019 0.0074 0.0074
Echinococcus granulosus FTZ F1 alpha 0.0019 0.0074 0.0074
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0063 0.044 0.3699
Schistosoma mansoni coup transcription factor 0.0019 0.0074 0.0074
Brugia malayi glutamate synthase 0.0019 0.0068 0.0164
Loa Loa (eye worm) hypothetical protein 0.0013 0.0019 0.0039
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0047 0.0307 0.1407
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0018 0.0067 0.0137
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.0123 0.0333
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0078 0.0564 0.2588
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0078 0.0564 0.2537
Onchocerca volvulus 0.0146 0.1135 0.318
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0125 0.0338
Brugia malayi Bloom's syndrome protein homolog 0.0025 0.0123 0.0296
Schistosoma mansoni ferritin 0.0034 0.0197 0.0197
Brugia malayi Bromodomain containing protein 0.0039 0.024 0.0578
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0012 0.0015 0.004
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0019 0.0068 0.0573
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0019 0.0068 0.0238
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0041 0.0254 0.1006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0226 0.0613
Echinococcus granulosus expressed protein 0.0034 0.0197 0.0197
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0019 0.0068 0.0313
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.003 0.0139
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0019 0.0068 0.0313
Trypanosoma cruzi trypanothione reductase, putative 0.0203 0.161 0.7384
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0044 0.012
Trypanosoma cruzi trypanothione reductase, putative 0.007 0.05 0.2295
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0125 0.0338
Schistosoma mansoni ferritin light chain 0.0034 0.0197 0.0197
Trypanosoma cruzi prolyl endopeptidase 0.0271 0.218 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0703 0.0703
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0125 0.0339
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0013 0.0019 0.0046
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0312 0.2526 0.8811
Mycobacterium tuberculosis Conserved protein 0.0116 0.0887 0.1402
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0019 0.0074 0.0178
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0013 0.0019 0.0046
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0116 0.0887 0.0887
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0019 0.0068 0.0313
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.003 0.0139
Giardia lamblia DINP protein human, muc B family 0.0014 0.003 0.012
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0108 0.0814 0.3734
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0014 0.003 0.0072
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0015 0.004
Entamoeba histolytica acyl-CoA synthetase, putative 0.0063 0.044 0.1534
Loa Loa (eye worm) hypothetical protein 0.0116 0.0887 0.1819
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0015 0.004
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0013 0.0019 0.0019
Schistosoma mansoni ap endonuclease 0.0019 0.0071 0.0071
Trypanosoma brucei NADH dehydrogenase 0.0019 0.0068 0.0313
Trypanosoma cruzi cysteine peptidase, putative 0.0047 0.0303 0.1392
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0018 0.0067 0.0563
Loa Loa (eye worm) transcription factor SMAD2 0.0238 0.191 0.3918
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0099 0.0738 0.0738
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.007 0.05 0.2243
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0459 0.0942
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0019 0.0068 0.0068
Echinococcus multilocularis protein cereblon 0.0353 0.2866 0.2866
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0459 0.0459
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0081 0.0589 0.2701
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0071 0.0597
Trichomonas vaginalis glucosylceramidase, putative 0.0451 0.3687 1
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0018 0.0067 0.0307
Loa Loa (eye worm) hypothetical protein 0.0353 0.2866 0.588
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0226 0.0613
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0044 0.012
Brugia malayi hypothetical protein 0.0144 0.1115 0.2685
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0034 0.0197 0.3345
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0226 0.0613
Mycobacterium tuberculosis Conserved protein 0.0116 0.0887 0.1402
Entamoeba histolytica acyl-CoA synthetase, putative 0.0063 0.044 0.1534
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0019 0.0068 0.0313
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0307 0.0832
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0028 0.015 0.0687
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0013 0.0019 0.0046
Brugia malayi Cation transporter family protein 0.0013 0.0019 0.0046
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0013 0.0019 0.0046
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0019 0.0068 0.0573
Trichomonas vaginalis antibiotic synthetase, putative 0.0018 0.0067 0.0181
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0019 0.0068 0.0313
Onchocerca volvulus 0.0013 0.0019 0.0053
Schistosoma mansoni glutamate synthase 0.0019 0.0068 0.0068
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0019 0.0068 0.0185
Echinococcus multilocularis FTZ F1 alpha 0.0019 0.0074 0.0074
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0206 0.0558
Brugia malayi RNA, U transporter 1 0.0158 0.1234 0.2972
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0038 0.0226 0.0977
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0063 0.044 0.3699
Plasmodium vivax acyl-CoA synthetase, putative 0.0047 0.0306 0.1902
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0044 0.0285 0.0416
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0206 0.0558
Brugia malayi Cathepsin L-like precursor 0.0012 0.0015 0.0035
Echinococcus multilocularis neuropeptide s receptor 0.096 0.7953 0.7953
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0703 0.0703
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0018 0.0067 0.0307
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0019 0.0074 0.0151
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.002 0.0076 0.0348
Mycobacterium ulcerans bacterioferritin BfrB 0.0034 0.0197 0.1657
Brugia malayi Probable ClpP-like protease 0.0081 0.0589 0.1418
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.007 0.05 0.2295
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0013 0.0019 0.0039
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0016 0.0045 0.0025
Trypanosoma brucei DNA polymerase IV, putative 0.0014 0.003 0.0139
Entamoeba histolytica cysteine protease, putative 0.0012 0.0015 0.0051
Loa Loa (eye worm) hypothetical protein 0.0028 0.015 0.0307
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0226 0.0613
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0013 0.0019 0.0046
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0459 0.0459
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0015 0.004
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0023 0.0105 0.0482
Loa Loa (eye worm) hypothetical protein 0.0116 0.0887 0.1819
Mycobacterium ulcerans monoxygenase 0.0019 0.0068 0.0573
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0013 0.0019 0.0019
Entamoeba histolytica thioredoxin reductase, putative 0.0019 0.0068 0.0238
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0018 0.0067 0.006
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0018 0.0067 0.0307
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0078 0.0564 0.2588
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0025 0.0046
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0271 0.218 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.022 0.022
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0019 0.0068 0.0164
Loa Loa (eye worm) hypothetical protein 0.002 0.008 0.0164
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0146 0.0395
Mycobacterium ulcerans lipase LipD 0.0116 0.0887 0.7459
Mycobacterium ulcerans acyl-CoA synthetase 0.0018 0.0067 0.0563
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0013 0.0019 0.0019
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0018 0.0067 0.0563
Echinococcus granulosus importin subunit beta 1 0.0055 0.0377 0.0377
Trichomonas vaginalis esterase, putative 0.0116 0.0887 0.2405
Echinococcus granulosus ferritin 0.0034 0.0197 0.0197
Toxoplasma gondii thioredoxin reductase 0.0203 0.161 0.7384
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0125 0.0338
Leishmania major acetyl-CoA synthetase, putative 0.0018 0.0067 0.0241
Brugia malayi hypothetical protein 0.011 0.0831 0.2002
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0028 0.015 0.0687
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0148 0.0401
Toxoplasma gondii ABC1 family protein 0.0116 0.0887 0.4067
Trichomonas vaginalis penicillin-binding protein, putative 0.0116 0.0887 0.2405
Giardia lamblia Alanyl dipeptidyl peptidase 0.0028 0.015 0.0593
Schistosoma mansoni zinc finger protein 0.0016 0.0043 0.0043
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0019 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0475 0.3894 0.7988
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0063 0.044 0.3699
Plasmodium falciparum acyl-CoA synthetase 0.0047 0.0306 0.1902
Schistosoma mansoni nAChR subunit 0.0013 0.0019 0.0019
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0071 0.044
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0019 0.0068 0.0068
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0019 0.0068 0.0313
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0418 0.0418
Echinococcus multilocularis zinc finger protein 0.002 0.008 0.008
Echinococcus granulosus glycine receptor subunit alpha 1 0.0013 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0013 0.0019 0.0039
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0099 0.0738 0.1777
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0028 0.015 0.042
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0019 0.0068 0.0247
Loa Loa (eye worm) hypothetical protein 0.0013 0.0019 0.0039
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0451 0.3687 0.888
Trichomonas vaginalis D-aminoacylase, putative 0.0116 0.0887 0.2405
Trypanosoma cruzi cysteine peptidase, putative 0.0047 0.0303 0.1392
Echinococcus multilocularis ferritin 0.0034 0.0197 0.0197
Loa Loa (eye worm) hypothetical protein 0.0019 0.0074 0.0151
Onchocerca volvulus 0.0018 0.0067 0.0187
Schistosoma mansoni nAChR subunit 0.0013 0.0019 0.0019
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0019 0.0068 0.0573
Schistosoma mansoni disulfide oxidoreductase 0.0019 0.0068 0.0068
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0331 0.0331
Schistosoma mansoni nAChR subunit 0.0013 0.0019 0.0019
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0041 0.0254 0.1165
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.027 0.0555
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0018 0.0067 0.006
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0063 0.013
Leishmania major cathepsin L-like protease 0.0047 0.0303 0.1333
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0034 0.0197 0.0273
Plasmodium vivax thioredoxin reductase, putative 0.0203 0.161 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0048 0.0099
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0019 0.0068 0.1157
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0071 0.026
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0019 0.0068 0.0247
Echinococcus granulosus glycine receptor subunit beta 0.0013 0.0019 0.0019
Leishmania major hypothetical protein, conserved 0.0019 0.0068 0.0247
Loa Loa (eye worm) hypothetical protein 0.0437 0.357 0.7323
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0262 0.2109 0.2109
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0014 0.003 0.0082
Brugia malayi steroid hormone receptor 0.0019 0.0074 0.0178
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0067 0.006
Schistosoma mansoni thyroid hormone receptor 0.0168 0.1318 0.1318
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0125 0.0776
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.2526 0.685
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0047 0.0306 0.0452
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0071 0.0325
Echinococcus granulosus tar DNA binding protein 0.0065 0.0459 0.0459
Schistosoma mansoni smad1 5 8 and 0.0016 0.0048 0.0048
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0078 0.0564 0.0564
Leishmania major hypothetical protein, conserved 0.0116 0.0887 0.4026
Leishmania major hypothetical protein, conserved 0.0025 0.0125 0.0509
Schistosoma mansoni ferritin 0.0034 0.0197 0.0197
Brugia malayi hypothetical protein 0.0353 0.2866 0.6903
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0013 0.0019 0.0046
Brugia malayi PHD-finger family protein 0.0025 0.0125 0.0302
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0011 0.00000023581 0.00000063951
Onchocerca volvulus Protein ultraspiracle homolog 0.0019 0.0074 0.0207
Trypanosoma cruzi NADH dehydrogenase, putative 0.0019 0.0068 0.0313
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.003 0.0139
Leishmania major NADH dehydrogenase, putative 0.0019 0.0068 0.0247
Mycobacterium ulcerans esterase/lipase LipP 0.0116 0.0887 0.7459
Trichomonas vaginalis penicillin-binding protein, putative 0.0116 0.0887 0.2405
Echinococcus granulosus cathepsin L cysteine proteinase 0.0012 0.0015 0.0015
Mycobacterium ulcerans beta-lactamase 0.0116 0.0887 0.7459
Trichomonas vaginalis glucosylceramidase, putative 0.0296 0.2389 0.6479
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0019 0.0068 0.1157
Brugia malayi AMP-binding enzyme family protein 0.0018 0.0067 0.0161
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0011 0.00000023581 0.00000082267
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.007 0.05 0.421
Leishmania major importin beta-1 subunit, putative 0.0045 0.0289 0.1266
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0015 0.004
Trypanosoma cruzi target of rapamycin kinase 3 0.0038 0.0226 0.1038
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0013 0.0019 0.0019
Schistosoma mansoni RAR-like nuclear receptor 0.0019 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0146 0.1135 0.2329
Schistosoma mansoni ran 0.0041 0.0254 0.0254
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0019 0.0068 0.0185
Trichomonas vaginalis mercuric reductase, putative 0.007 0.05 0.1357
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0015 0.004
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0025 0.0086
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0081 0.0589 0.2701
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0016 0.0044 0.0203
Brugia malayi Peroxidasin 0.0437 0.357 0.8598
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0081 0.0589 1
Schistosoma mansoni glutamate synthase 0.0019 0.0068 0.0068
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0125 0.0776
Loa Loa (eye worm) hypothetical protein 0.0033 0.0187 0.0383
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0249 0.0675
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.027 0.0733
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0028 0.015 0.0687
Trypanosoma brucei DNA polymerase IV, putative 0.0014 0.003 0.0139
Trichomonas vaginalis glucosylceramidase, putative 0.0296 0.2389 0.6479
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0067 0.006
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.2526 0.685
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0703 0.0703
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0459 0.0459
Schistosoma mansoni nAChR subunit 0.0013 0.0019 0.0019
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.007 0.05 0.2295
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0019 0.0068 0.0185
Echinococcus granulosus peroxidasin 0.0437 0.357 0.357
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.003 0.0139
Trichomonas vaginalis apoptosis inducing factor, putative 0.0019 0.0068 0.0185
Echinococcus multilocularis acylamino acid releasing enzyme 0.0028 0.015 0.015
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0019 0.0068 0.0164
Schistosoma mansoni DNA polymerase eta 0.0033 0.0187 0.0187
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.007 0.05 0.2295
Echinococcus granulosus GPCR family 2 0.0099 0.0738 0.0738
Plasmodium vivax acetyl-CoA synthetase, putative 0.0018 0.0067 0.0416
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0013 0.0019 0.0019
Onchocerca volvulus Putative nachr subunit 0.0013 0.0019 0.0053
Trichomonas vaginalis DNA polymerase eta, putative 0.0014 0.003 0.0082
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0475 0.3894 0.9378
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0028 0.0145 0.0902
Schistosoma mansoni smad 0.0016 0.0048 0.0048
Echinococcus multilocularis ecdysone induced protein 78C 0.0019 0.0074 0.0074
Leishmania major phosphatidylinositol 3-kinase, putative 0.0016 0.0044 0.0137
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0271 0.218 0.218
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0125 0.0573
Echinococcus multilocularis beta LACTamase domain containing family member 0.0116 0.0887 0.0887
Mycobacterium tuberculosis Probable lipase LipD 0.0116 0.0887 0.1402
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0015 0.004
Loa Loa (eye worm) prolyl oligopeptidase 0.0028 0.015 0.0307
Mycobacterium ulcerans NADH dehydrogenase 0.0019 0.0068 0.0573
Loa Loa (eye worm) ctsf protein 0.0012 0.0015 0.003
Loa Loa (eye worm) hypothetical protein 0.0047 0.0306 0.0628
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0018 0.0067 0.006
Onchocerca volvulus 0.0012 0.0015 0.0041
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0071 0.0281
Loa Loa (eye worm) hypothetical protein 0.0081 0.0589 0.1208
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0018 0.0067 0.0563
Onchocerca volvulus 0.0012 0.0015 0.0041
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0019 0.0068 0.0573
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0052 0.0344 0.0829
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0047 0.0307 0.0739
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0074 0.0178
Mycobacterium ulcerans DNA polymerase IV 0.0014 0.003 0.0256
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.007 0.05 0.0769
Echinococcus granulosus thioredoxin glutathione reductase 0.0203 0.161 0.161
Schistosoma mansoni nAChR subunit 0.0013 0.0019 0.0019
Entamoeba histolytica disulphide oxidoreductase, putative 0.0019 0.0068 0.0238
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.007 0.05 0.2295
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0019 0.0068 0.1157
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0226 0.0613
Leishmania major cathepsin L-like protease 0.0047 0.0303 0.1333
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.003
Schistosoma mansoni transcription factor LCR-F1 0.011 0.0831 0.0831
Plasmodium falciparum ferrodoxin reductase-like protein 0.0019 0.0068 0.0423
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0081 0.0589 0.4955
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.0703 0.1442
Loa Loa (eye worm) hypothetical protein 0.0017 0.0058 0.0119
Trypanosoma cruzi cysteine peptidase, putative 0.0012 0.0015 0.0067
Brugia malayi nuclear hormone receptor 0.0019 0.0074 0.0178
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0028 0.015 0.0406
Loa Loa (eye worm) hypothetical protein 0.0019 0.0074 0.0151
Loa Loa (eye worm) hypothetical protein 0.0437 0.357 0.7323
Loa Loa (eye worm) hypothetical protein 0.0047 0.0306 0.0628
Brugia malayi Muscleblind-like protein 0.0145 0.1128 0.2716
Trypanosoma brucei ISWI complex protein 0.0016 0.0043 0.0197
Trypanosoma cruzi ISWI complex protein 0.0016 0.0043 0.0197
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0019 0.0074 0.0207
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0081 0.0589 0.3658
Brugia malayi MH1 domain containing protein 0.0016 0.0048 0.0116
Schistosoma mansoni retinoic acid receptor RXR 0.0019 0.0074 0.0074
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0019 0.0074 0.0074
Echinococcus granulosus dna polymerase kappa 0.0014 0.003 0.003
Onchocerca volvulus 0.0013 0.0019 0.0053
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0105 0.0105
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0019 0.0068 0.0068
Brugia malayi Calcitonin receptor-like protein seb-1 0.0312 0.2523 0.6076
Echinococcus multilocularis dna polymerase kappa 0.0014 0.003 0.003
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0016 0.0044 0.0137
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0303 0.1392
Loa Loa (eye worm) hypothetical protein 0.0131 0.1011 0.2073
Trichomonas vaginalis D-aminoacylase, putative 0.0116 0.0887 0.2405
Mycobacterium ulcerans acyl-CoA synthetase 0.0018 0.0067 0.0563
Trypanosoma cruzi importin beta-1 subunit, putative 0.0045 0.0289 0.1325
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0459 0.0459
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0047 0.0307 0.107
Schistosoma mansoni hypothetical protein 0.0099 0.0738 0.0738
Echinococcus granulosus peptidase Clp S14 family 0.0053 0.0356 0.0356
Schistosoma mansoni sulfide quinone reductase 0.0019 0.0068 0.0068
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0038 0.0226 0.1038
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0028 0.015 0.015
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0013 0.0019 0.0019
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.007 0.05 0.0769
Loa Loa (eye worm) hypothetical protein 0.0013 0.0019 0.0039
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0019 0.0074 0.0178
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0013 0.0019 0.0019
Echinococcus multilocularis peptidase Clp (S14 family) 0.0053 0.0356 0.0356
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.007 0.05 0.2295
Loa Loa (eye worm) hypothetical protein 0.0043 0.027 0.0555
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0108 0.0814 0.1283
Brugia malayi Bromodomain containing protein 0.0077 0.0554 0.1334
Loa Loa (eye worm) hypothetical protein 0.0019 0.0074 0.0151
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0067 0.006
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0013 0.0019 0.0046
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0028 0.015 0.0687
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0013 0.0019 0.0019
Loa Loa (eye worm) animal heme peroxidase 0.0437 0.357 0.7323
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0012 0.0015 0.004
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0012 0.0015 0.0091
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0019 0.0068 0.0313
Trypanosoma cruzi NADH dehydrogenase, putative 0.0019 0.0068 0.0313
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0022 0.0099 0.0452
Schistosoma mansoni peptidase Clp (S14 family) 0.0081 0.0589 0.0589
Loa Loa (eye worm) hypothetical protein 0.0437 0.357 0.7323
Trypanosoma brucei importin beta-1 subunit, putative 0.0055 0.0377 0.1728
Leishmania major trypanothione reductase 0.0203 0.161 0.7367
Schistosoma mansoni peroxidasin 0.0437 0.357 0.357
Brugia malayi AMP-binding enzyme family protein 0.0018 0.0067 0.0161
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0019 0.0074 0.0074
Echinococcus granulosus glycine receptor subunit beta 0.0013 0.0019 0.0019
Trypanosoma brucei trypanothione reductase 0.0203 0.161 0.7384
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.007 0.05 0.05
Plasmodium vivax ferrodoxin reductase, putative 0.0019 0.0068 0.0423
Brugia malayi hypothetical protein 0.0025 0.0125 0.0301
Loa Loa (eye worm) hypothetical protein 0.0145 0.1128 0.2313
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0047 0.0307 0.0307
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0015 0.004
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0019 0.0068 0.0185
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0068 0.0313
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0018 0.0067 0.0563
Brugia malayi Importin beta-1 subunit 0.0055 0.0377 0.0908
Loa Loa (eye worm) hypothetical protein 0.0025 0.0125 0.0256
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0384 0.0788
Trypanosoma brucei importin beta-1 subunit, putative 0.0055 0.0377 0.1728
Leishmania major 4-coumarate:coa ligase-like protein 0.0063 0.044 0.1962
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0012 0.0015 0.003
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0074 0.0178
Schistosoma mansoni acetyl-CoA synthetase 0.0018 0.0067 0.0067
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0013 0.0019 0.0039
Trichomonas vaginalis glucosylceramidase, putative 0.0296 0.2389 0.6479
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0017 0.0055 0.0339
Mycobacterium tuberculosis Probable hydrolase 0.0116 0.0887 0.1402
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0058 0.0058
Echinococcus multilocularis Niemann Pick C1 protein 0.01 0.0747 0.0747
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0013 0.0019 0.0039
Brugia malayi Blistered cuticle protein 3 0.0437 0.357 0.8598
Loa Loa (eye worm) hypothetical protein 0.0018 0.0067 0.0137
Brugia malayi CHE-14 protein 0.0043 0.027 0.0651
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0074 0.0178
Onchocerca volvulus Huntingtin homolog 0.0131 0.1011 0.2831
Loa Loa (eye worm) hypothetical protein 0.0131 0.1011 0.2073
Schistosoma mansoni sulfide quinone reductase 0.0019 0.0068 0.0068
Loa Loa (eye worm) beta-lactamase 0.0116 0.0887 0.1819
Echinococcus granulosus nAChR subunit 0.0013 0.0019 0.0019
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0012 0.0015 0.004
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.007 0.05 0.421
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0145 0.0575
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0028 0.015 0.0687
Loa Loa (eye worm) MH2 domain-containing protein 0.0238 0.191 0.3918
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0053 0.0356 0.0533
Onchocerca volvulus Cathepsin L homolog 0.0012 0.0015 0.0041
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0019 0.0068 0.0068
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0044 0.012
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0081 0.0589 0.3658
Echinococcus multilocularis expressed protein 0.0034 0.0197 0.0197
Leishmania major DNA polymerase eta, putative 0.0023 0.0105 0.0417
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0451 0.3687 0.7564
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0019 0.0068 0.0185
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0013 0.0019 0.0019
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0012 0.0015 0.0091
Trypanosoma cruzi major cysteine proteinase, putative 0.0037 0.022 0.1007
Loa Loa (eye worm) hypothetical protein 0.0047 0.0306 0.0628
Trypanosoma cruzi DNA polymerase kappa, putative 0.0014 0.003 0.0139
Brugia malayi Thioredoxin reductase 0.0203 0.161 0.3878
Leishmania major hypothetical protein, conserved 0.0019 0.0068 0.0247
Brugia malayi prolyl oligopeptidase family protein 0.0028 0.015 0.0361
Echinococcus multilocularis nAChR subunit 0.0013 0.0019 0.0019
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0081 0.0589 0.0589
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.01 0.0747 0.2606
Toxoplasma gondii cathepsin CPL 0.0012 0.0015 0.0067
Schistosoma mansoni hypothetical protein 0.0041 0.0257 0.0257
Loa Loa (eye worm) hypothetical protein 0.0116 0.0887 0.1819
Onchocerca volvulus 0.0013 0.0019 0.0053
Echinococcus multilocularis prolyl endopeptidase 0.0271 0.218 0.218
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0028 0.015 0.0523
Leishmania major GTP-binding protein, putative 0.0041 0.0254 0.1105
Brugia malayi Cation transporter family protein 0.0013 0.0019 0.0046
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0015 0.004
Echinococcus multilocularis smad 0.0016 0.0048 0.0048
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0013 0.0019 0.0046
Leishmania major oligopeptidase b 0.0108 0.0814 0.3691
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0018 0.0067 0.006
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.007 0.05 0.2295
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0019 0.0074 0.0074
Schistosoma mansoni importin beta-1 0.0055 0.0377 0.0377
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0025 0.0113
Schistosoma mansoni microtubule-associated protein tau 0.1204 1 1
Treponema pallidum oxidoreductase 0.0019 0.0068 0.027
Brugia malayi Cathepsin L-like precursor 0.0012 0.0015 0.0035
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.027 0.027
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0019 0.0068 0.0062
Onchocerca volvulus 0.005 0.0331 0.0928
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0063 0.044 0.3699
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0125 0.0573
Trypanosoma cruzi DNA polymerase kappa, putative 0.0014 0.003 0.0139
Loa Loa (eye worm) hypothetical protein 0.0437 0.357 0.7323
Onchocerca volvulus 0.0116 0.0887 0.2484
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0116 0.0887 0.0887
Schistosoma mansoni hypothetical protein 0.0041 0.0257 0.0257
Loa Loa (eye worm) glutathione reductase 0.0203 0.161 0.3303
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.003 0.0139
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.007 0.05 0.421
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0018 0.0067 0.006
Schistosoma mansoni smad1 5 8 and 0.0016 0.0048 0.0048
Echinococcus granulosus zinc finger protein 0.002 0.008 0.008
Brugia malayi follicle stimulating hormone receptor 0.0506 0.4152 1
Echinococcus multilocularis tumor protein p63 0.0342 0.2778 0.2778
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0116 0.0887 0.1402
Loa Loa (eye worm) animal heme peroxidase 0.0437 0.357 0.7323
Echinococcus granulosus protein cereblon 0.0353 0.2866 0.2866
Echinococcus multilocularis glycine receptor subunit beta 0.0013 0.0019 0.0019
Onchocerca volvulus Peroxidase homolog 0.0437 0.357 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0019 0.0074 0.0074
Treponema pallidum thioredoxin reductase (trxB) 0.0019 0.0068 0.027
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0099 0.0738 0.0738
Onchocerca volvulus 0.0116 0.0887 0.2484
Onchocerca volvulus Bile acid receptor homolog 0.0019 0.0074 0.0207
Loa Loa (eye worm) hypothetical protein 0.01 0.0747 0.1532
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0018 0.0067 0.0067
Brugia malayi AMP-binding enzyme family protein 0.0063 0.044 0.1059
Onchocerca volvulus Prolyl endopeptidase homolog 0.0271 0.218 0.6107
Mycobacterium ulcerans acyl-CoA synthetase 0.0018 0.0067 0.0563
Loa Loa (eye worm) hypothetical protein 0.0013 0.0019 0.0039
Mycobacterium ulcerans hypothetical protein 0.0019 0.0068 0.0573
Brugia malayi Cathepsin L-like precursor 0.0012 0.0015 0.0035
Trypanosoma cruzi ISWI complex protein 0.0016 0.0043 0.0197
Echinococcus granulosus Smad4 0.0016 0.0048 0.0048
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0018 0.0067 0.0307
Schistosoma mansoni hypothetical protein 0.0213 0.1697 0.1697
Brugia malayi hypothetical protein 0.0016 0.005 0.0119
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.007 0.05 0.05
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0125 0.0776
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0071 0.0171
Loa Loa (eye worm) hypothetical protein 0.0042 0.0261 0.0535
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0071 0.0192
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0018 0.0067 0.006
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0703 0.0703
Loa Loa (eye worm) hypothetical protein 0.0047 0.0306 0.0628
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.022 0.022
Schistosoma mansoni glutamate synthase 0.0019 0.0068 0.0068
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0303 0.1392
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0048 0.0048
Echinococcus granulosus smad 0.0016 0.0048 0.0048
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0013 0.0019 0.0046
Brugia malayi ImpB/MucB/SamB family protein 0.0014 0.003 0.0073
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0019 0.0068 0.0068
Schistosoma mansoni hypothetical protein 0.0552 0.4535 0.4535
Trypanosoma cruzi oligopeptidase b 0.0108 0.0814 0.3734
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0034 0.0197 0.1657
Loa Loa (eye worm) hypothetical protein 0.0013 0.0019 0.0039
Mycobacterium ulcerans acyl-CoA synthetase 0.0018 0.0067 0.0563
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.0703 0.1692
Schistosoma mansoni zinc finger protein 0.002 0.008 0.008
Echinococcus multilocularis microtubule associated protein 2 0.1204 1 1
Echinococcus granulosus bloom syndrome protein 0.0025 0.0123 0.0123
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0041 0.0254 0.1578
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0018 0.0067 0.0307
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0015 0.004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0125 0.0339
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0013 0.0019 0.0039
Onchocerca volvulus Peroxidasin homolog 0.0437 0.357 1
Toxoplasma gondii HEAT repeat-containing protein 0.0055 0.0377 0.1728
Brugia malayi Cathepsin L-like precursor 0.0012 0.0015 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0148 0.0401
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0148 0.0401
Mycobacterium ulcerans acyl-CoA synthetase 0.0018 0.0067 0.0563
Entamoeba histolytica cysteine proteinase, putative 0.0012 0.0015 0.0051
Brugia malayi AMP-binding enzyme family protein 0.0018 0.0067 0.0161
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.2526 0.685
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.2522 0.6841
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0303 0.1392
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0028 0.015 0.0624
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0018 0.0067 0.0233
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0125 0.0339
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0418 0.3518
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0081 0.0589 0.2332
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0013 0.0019 0.0019
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.006 0.0418 0.1863
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0071 0.0071
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0019 0.0068 0.0062
Schistosoma mansoni ferritin 0.0034 0.0197 0.0197
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0018 0.0067 0.0563
Trypanosoma cruzi DNA polymerase eta, putative 0.0033 0.0187 0.0856
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0019 0.0068 0.0313
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0019 0.0068 0.0313
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0145 0.0902
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0014 0.003 0.0062
Schistosoma mansoni apoferritin-2 0.0034 0.0197 0.0197
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0206 0.0558
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0078 0.0564 0.1359
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0019 0.0068 0.0068
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0048 0.0048
Mycobacterium tuberculosis Probable dehydrogenase 0.0019 0.0068 0.0062
Echinococcus multilocularis cysteine protease 0.0012 0.0015 0.0015
Leishmania major 4-coumarate:coa ligase-like protein 0.0063 0.044 0.1962
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0459 0.0459
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0206 0.0558
Trypanosoma cruzi cruzipain precursor, putative 0.0047 0.0303 0.1392
Onchocerca volvulus 0.0018 0.0067 0.0187
Echinococcus multilocularis peroxidasin 0.0437 0.357 0.357
Trichomonas vaginalis glucosylceramidase, putative 0.0296 0.2389 0.6479
Onchocerca volvulus Peroxidase homolog 0.0437 0.357 1
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0016 0.0044 0.0203
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0078 0.0564 0.2588
Trichomonas vaginalis glucosylceramidase, putative 0.0451 0.3687 1
Trypanosoma brucei hypothetical protein, conserved 0.0019 0.0068 0.0313
Echinococcus granulosus Dipeptidyl peptidase 9 0.0028 0.015 0.015
Brugia malayi Animal haem peroxidase family protein 0.0437 0.357 0.8598
Brugia malayi Steroid receptor seven-up type 2 0.0019 0.0074 0.0178
Schistosoma mansoni ran 0.0041 0.0254 0.0254
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0019 0.0074 0.0074
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0019 0.0068 0.0062
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0303 0.1392
Loa Loa (eye worm) hypothetical protein 0.0437 0.357 0.7323
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0242 0.1943 0.313
Brugia malayi AMP-binding enzyme family protein 0.0063 0.044 0.1059
Trichomonas vaginalis DNA helicase recq1, putative 0.0025 0.0123 0.0333
Schistosoma mansoni cathepsin F (C01 family) 0.0012 0.0015 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0074 0.0178
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0013 0.0019 0.0046
Echinococcus multilocularis neuropeptide receptor A26 0.096 0.7953 0.7953
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0028 0.015 0.0687
Loa Loa (eye worm) programmed cell death 8 0.0019 0.0068 0.014
Onchocerca volvulus 0.0013 0.0019 0.0053
Echinococcus granulosus neuropeptide receptor A26 0.096 0.7953 0.7953
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0307 0.0832
Loa Loa (eye worm) hypothetical protein 0.0116 0.0887 0.1819
Onchocerca volvulus 0.0013 0.0019 0.0053
Schistosoma mansoni hypothetical protein 0.0148 0.1156 0.1156
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0019 0.0068 0.0164
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0011 0.00000023581 0.00000063951
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0303 0.1392
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.2522 0.6841
Loa Loa (eye worm) hypothetical protein 0.0013 0.0019 0.0039
Trypanosoma brucei unspecified product 0.0014 0.003 0.0139
Schistosoma mansoni Smad4 0.0016 0.0048 0.0048
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0058 0.0058
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0028 0.015 0.015
Loa Loa (eye worm) animal heme peroxidase 0.0437 0.357 0.7323
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0019 0.0074 0.0074
Loa Loa (eye worm) RecQ helicase 0.0025 0.0123 0.0252
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0043 0.0269 0.1236
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0012 0.0015 0.004
Brugia malayi prolyl oligopeptidase family protein 0.0028 0.015 0.0361
Mycobacterium ulcerans glutamate synthase subunit beta 0.0019 0.0068 0.0573
Schistosoma mansoni hypothetical protein 0.0353 0.2866 0.2866
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0019 0.0074 0.0178
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0013 0.0019 0.0019
Trichomonas vaginalis glucosylceramidase, putative 0.0451 0.3687 1
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0013 0.0019 0.0019
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0071 0.0071
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0019 0.0068 0.0068
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0053 0.0356 0.2993
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0019 0.0068 0.0423
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0019 0.0068 0.0068
Mycobacterium tuberculosis Conserved protein 0.0116 0.0887 0.1402
Toxoplasma gondii propionate-CoA ligase 0.0018 0.0067 0.0307
Echinococcus multilocularis geminin 0.0552 0.4535 0.4535
Toxoplasma gondii NADPH-glutathione reductase 0.007 0.05 0.2295
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0262 0.2109 0.2109
Giardia lamblia Glutamate synthase 0.0019 0.0068 0.027
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0019 0.0074 0.0074
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0074 0.0178
Schistosoma mansoni cathepsin F (C01 family) 0.0012 0.0015 0.0015
Entamoeba histolytica prolyl oligopeptidase family protein 0.0028 0.015 0.0523
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.0074 0.0074
Mycobacterium ulcerans acyl-CoA synthetase 0.0018 0.0067 0.0563
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0168 0.0456
Echinococcus granulosus Niemann Pick C1 protein 0.0142 0.1105 0.1105
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0013 0.0019 0.0046
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.007 0.05 0.2295
Plasmodium vivax hypothetical protein, conserved 0.0116 0.0887 0.5507
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0108 0.0814 0.6848
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0013 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.0021 0.0089 0.0089
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0008 0.0008
Mycobacterium ulcerans acyl-CoA synthetase 0.0018 0.0067 0.0563
Trypanosoma brucei DNA polymerase IV, putative 0.0014 0.003 0.0139
Brugia malayi latrophilin 2 splice variant baaae 0.0213 0.1697 0.4086
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.007 0.05 0.3108
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0019 0.0068 0.0423
Loa Loa (eye worm) hypothetical protein 0.0013 0.0019 0.0039
Giardia lamblia Fructose-bisphosphate aldolase 0.0312 0.2526 1
Loa Loa (eye worm) hypothetical protein 0.0437 0.357 0.7323
Loa Loa (eye worm) cysteine protease 0.0012 0.0015 0.003
Brugia malayi hypothetical protein 0.0146 0.1135 0.2734
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.2526 0.685
Trypanosoma cruzi hypothetical protein, conserved 0.0116 0.0887 0.4067
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0012 0.0015 0.004
Echinococcus granulosus glutamate synthase 0.0019 0.0068 0.0068
Mycobacterium ulcerans ferredoxin reductase 0.0019 0.0068 0.0573
Echinococcus multilocularis snurportin 1 0.0592 0.4875 0.4875
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0012 0.0015 0.0015
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0312 0.2526 0.8811
Echinococcus granulosus cathepsin l cysteine peptidase 0.0012 0.0015 0.0015
Leishmania major acetoin dehydrogenase e3 component-like protein 0.007 0.05 0.2243
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.007 0.05 0.8496
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0019 0.0068 0.0573
Mycobacterium ulcerans acyl-CoA synthetase 0.0018 0.0067 0.0563
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.0418 0.1007
Loa Loa (eye worm) hypothetical protein 0.0019 0.0074 0.0151
Loa Loa (eye worm) hypothetical protein 0.005 0.0331 0.068
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0116 0.0887 0.1402
Schistosoma mansoni ferritin 0.0034 0.0197 0.0197
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0018 0.0067 0.0563
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0013 0.0019 0.0046
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0019 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0437 0.357 0.7323
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0152 0.1189 1
Loa Loa (eye worm) ACC-1 protein 0.0013 0.0019 0.0039
Onchocerca volvulus Chorion peroxidase homolog 0.0437 0.357 1
Trypanosoma brucei DNA polymerase eta, putative 0.0033 0.0187 0.0856
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.003 0.0139
Echinococcus granulosus cathepsin l1 0.0012 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0013 0.0019 0.0039
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0018 0.0067 0.0563
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0078 0.0078
Schistosoma mansoni hypothetical protein 0.0552 0.4535 0.4535
Trypanosoma cruzi DNA polymerase kappa, putative 0.0014 0.003 0.0139
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0019 0.0068 0.0185
Entamoeba histolytica prolyl oligopeptidase family protein 0.0028 0.015 0.0523
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0015 0.004
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0071 0.044
Trypanosoma cruzi oligopeptidase b 0.0108 0.0814 0.3734
Echinococcus multilocularis importin subunit beta 1 0.0055 0.0377 0.0377
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0019 0.0068 0.0423
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0019 0.0068 0.0573
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0048 0.0048
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0071 0.1204
Trypanosoma cruzi cysteine peptidase, putative 0.0047 0.0303 0.1392
Treponema pallidum fructose-bisphosphate aldolase 0.0312 0.2526 1
Loa Loa (eye worm) animal heme peroxidase 0.0437 0.357 0.7323
Toxoplasma gondii selenide, water dikinase 0.0019 0.0068 0.0313
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.007 0.05 0.0769
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.2526 0.685
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0307 0.0832
Mycobacterium tuberculosis Probable reductase 0.0019 0.0068 0.0062
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0019 0.0068 0.0573
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0013 0.0019 0.0019
Loa Loa (eye worm) thioredoxin reductase 0.0203 0.161 0.3303
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0016 0.0044 0.0044
Trichomonas vaginalis antibiotic synthetase, putative 0.0018 0.0067 0.0181
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0041 0.0254 0.0254
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0041 0.0254 0.1165
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0105 0.0482
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0012 0.0015 0.004
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.007 0.05 0.1205
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0013 0.0019 0.0046
Brugia malayi prolyl oligopeptidase family protein 0.0271 0.218 0.5251
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0019 0.0074 0.0074
Plasmodium vivax glutathione reductase, putative 0.0203 0.161 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0703 0.0703
Echinococcus granulosus Niemann Pick C1 protein 0.01 0.0747 0.0747
Echinococcus multilocularis thioredoxin glutathione reductase 0.0203 0.161 0.161
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0041 0.0254 0.1578
Echinococcus multilocularis GPCR, family 2 0.0099 0.0738 0.0738
Loa Loa (eye worm) blistered cuticle protein 3 0.0437 0.357 0.7323
Entamoeba histolytica hypothetical protein 0.011 0.0831 0.29
Echinococcus multilocularis Niemann Pick C1 protein 0.0142 0.1105 0.1105
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0028 0.015 0.0523
Onchocerca volvulus 0.0012 0.0015 0.0041
Plasmodium falciparum glutathione reductase 0.0203 0.161 1
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0018 0.0067 0.0241
Toxoplasma gondii exonuclease III APE 0.0019 0.0071 0.0325
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0053 0.0356 0.0533
Echinococcus multilocularis glycine receptor subunit beta 0.0013 0.0019 0.0019
Onchocerca volvulus Cathepsin L homolog 0.0012 0.0015 0.0041
Echinococcus multilocularis cathepsin L cysteine protease 0.0012 0.0015 0.0015
Schistosoma mansoni hypothetical protein 0.0016 0.0043 0.0043
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0019 0.0068 0.0062
Treponema pallidum NADH oxidase 0.007 0.05 0.1981
Loa Loa (eye worm) hypothetical protein 0.0039 0.024 0.0493
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0019 0.0074 0.0151
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0047 0.0307 0.0307
Mycobacterium ulcerans acyl-CoA synthetase 0.0063 0.044 0.3699
Trichomonas vaginalis ran, putative 0.0041 0.0254 0.0689
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0116 0.0887 0.1819
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0047 0.0307 0.107
Trichomonas vaginalis glucosylceramidase, putative 0.0296 0.2389 0.6479
Brugia malayi beta-lactamase family protein 0.0116 0.0887 0.2135
Mycobacterium ulcerans bacterioferritin BfrA 0.0034 0.0197 0.1657
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0019 0.0068 0.0238
Brugia malayi MH1 domain containing protein 0.0016 0.0048 0.0116
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0013 0.0019 0.0019
Plasmodium vivax importin-beta 2, putative 0.0055 0.0377 0.2341
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0013 0.0019 0.0046
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0152 0.1189 0.1896
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0044 0.0285 0.0416
Loa Loa (eye worm) hypothetical protein 0.0374 0.3047 0.625
Schistosoma mansoni hypothetical protein 0.0099 0.0738 0.0738
Brugia malayi Niemann-Pick C1 protein precursor 0.01 0.0747 0.1799
Mycobacterium ulcerans flavoprotein disulfide reductase 0.007 0.05 0.421
Onchocerca volvulus 0.0116 0.0887 0.2484
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0312 0.2523 0.5175
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0074 0.0074
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0025 0.0113
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0063 0.044 0.3699
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0071 0.0145
Trypanosoma brucei hypothetical protein, conserved 0.0116 0.0887 0.4067
Schistosoma mansoni patched 1 0.0043 0.027 0.027
Mycobacterium ulcerans DNA polymerase IV 0.0014 0.003 0.0256
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0206 0.0558
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0018 0.0067 0.0307
Brugia malayi beta-lactamase 0.0116 0.0887 0.2135
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0013 0.0019 0.0019
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0019 0.0074 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.015 0.0406
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0108 0.0814 0.6848
Brugia malayi AMP-binding enzyme family protein 0.0018 0.0067 0.0161
Loa Loa (eye worm) hypothetical protein 0.0013 0.0019 0.0039
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0044 0.0285 0.0416
Loa Loa (eye worm) hypothetical protein 0.0013 0.0019 0.0039
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0028 0.015 0.015
Schistosoma mansoni hypothetical protein 0.0041 0.0257 0.0257
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.003 0.0139
Onchocerca volvulus Huntingtin homolog 0.0131 0.1011 0.2831
Brugia malayi photoreceptor-specific nuclear receptor 0.0019 0.0074 0.0178
Onchocerca volvulus 0.0437 0.357 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0074 0.0151
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0063 0.044 0.0902
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0013 0.0019 0.0039
Trichomonas vaginalis D-aminoacylase, putative 0.0116 0.0887 0.2405
Loa Loa (eye worm) hypothetical protein 0.0437 0.357 0.7323
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0018 0.0067 0.0137
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0125 0.0573
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0074 0.0178
Onchocerca volvulus Glucosylceramidase homolog 0.0296 0.2389 0.6692
Schistosoma mansoni hypothetical protein 0.0041 0.0257 0.0257
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0019 0.0068 0.0185
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.007 0.05 0.2295
Trichomonas vaginalis ferritin, putative 0.0034 0.0197 0.0534
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0019 0.0074 0.0074
Brugia malayi ImpB/MucB/SamB family protein 0.0033 0.0187 0.045
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0108 0.0814 0.3734
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0019 0.0074 0.0074
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0044 0.012
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0821 0.679 0.679
Leishmania major DNA polymerase eta, putative 0.0033 0.0187 0.0794
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.007 0.05 0.05
Schistosoma mansoni hypothetical protein 0.0011 0.0008 0.0008
Brugia malayi ecdysteroid receptor 0.0019 0.0074 0.0178
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0125 0.0573
Schistosoma mansoni terminal deoxycytidyl transferase 0.0014 0.003 0.003
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0012 0.0015 0.003
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0019 0.0068 0.014
Loa Loa (eye worm) hypothetical protein 0.0013 0.0019 0.0039
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0041 0.0254 0.0521
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0078 0.0564 0.1157
Brugia malayi Smad1 0.0016 0.0048 0.0116
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0016 0.0044 0.0044
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0025 0.0067
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0044 0.0285 0.0416
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.006 0.0418 0.0418
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0019 0.0068 0.0238
Echinococcus multilocularis transcription factor Dp 1 0.0045 0.029 0.029
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0013 0.0019 0.0019
Echinococcus granulosus glycine receptor subunit alpha 1 0.0013 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0052 0.0351 0.072
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0045 0.0289 0.0784
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0014 0.003 0.003
Loa Loa (eye worm) prolyl oligopeptidase 0.0028 0.015 0.0307
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0019 0.0068 0.0423
Toxoplasma gondii ATPase, AAA family protein 0.0011 0.00000023581 0.0000010815
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0592 0.4875 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0303 0.1392
Echinococcus granulosus replication factor c subunit 1 0.0011 0.00000023581 0.00000023581
Onchocerca volvulus 0.0437 0.357 1
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0108 0.0814 0.3691
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0014 0.003 0.003
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0013 0.0019 0.0019
Leishmania major dihydrolipoamide dehydrogenase, putative 0.007 0.05 0.2243
Loa Loa (eye worm) hypothetical protein 0.0437 0.357 0.7323
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0081 0.0589 0.4955
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.003 0.0139
Onchocerca volvulus Dual oxidase homolog 0.0437 0.357 1
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0019 0.0068 0.0573
Brugia malayi Animal haem peroxidase family protein 0.0437 0.357 0.8598
Echinococcus granulosus neuropeptide s receptor 0.096 0.7953 0.7953
Mycobacterium ulcerans hypothetical protein 0.0116 0.0887 0.7459
Trichomonas vaginalis glutamate synthase, putative 0.0019 0.0068 0.0185
Loa Loa (eye worm) hypothetical protein 0.0044 0.0277 0.0568
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0015 0.004
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0016 0.0044 0.0203
Leishmania major cathepsin L-like protease 0.0047 0.0303 0.1333
Schistosoma mansoni apoferritin-2 0.0034 0.0197 0.0197
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0052 0.0344 0.0829
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0028 0.015 0.015
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0459 0.0459
Entamoeba histolytica hypothetical protein 0.011 0.0831 0.29
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.007 0.05 0.2295
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0019 0.0068 0.0068
Echinococcus multilocularis muscleblind protein 0.0145 0.1128 0.1128
Schistosoma mansoni hypothetical protein 0.0019 0.0068 0.0068
Mycobacterium leprae Probable lipase LipE 0.0116 0.0887 0.7459
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0097 0.0604
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0418 0.3518
Echinococcus multilocularis replication factor c subunit 1 0.0011 0.00000023581 0.00000023581
Schistosoma mansoni bromodomain containing protein 0.0065 0.0454 0.0454
Echinococcus multilocularis cysteine protease 0.0012 0.0015 0.0015
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0071 0.0066
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0012 0.0015 0.004
Onchocerca volvulus 0.0012 0.0015 0.0041
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0048 0.0048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0206 0.0558
Plasmodium vivax hypothetical protein, conserved 0.0028 0.015 0.0931
Echinococcus granulosus transcription factor Dp 1 0.0045 0.029 0.029
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0019 0.0068 0.0573
Echinococcus multilocularis thyroid hormone receptor alpha 0.0168 0.1318 0.1318
Onchocerca volvulus 0.0013 0.0019 0.0053
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0028 0.015 0.0687
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0016 0.0044 0.0203
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0058 0.0058
Plasmodium vivax vivapain-2 0.0012 0.0015 0.0091
Loa Loa (eye worm) LGC-31 protein 0.0013 0.0019 0.0039
Loa Loa (eye worm) hypothetical protein 0.0145 0.1128 0.2313
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0105 0.0105
Treponema pallidum bacterioferrin (TpF1) 0.0034 0.0197 0.078
Onchocerca volvulus 0.0019 0.0068 0.0191
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0019 0.0074 0.0151
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0146 0.0395
Echinococcus granulosus snurportin 1 0.0592 0.4875 0.4875
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0459 0.0942
Toxoplasma gondii hypothetical protein 0.0028 0.015 0.0687
Mycobacterium ulcerans acyl-CoA synthetase 0.0063 0.044 0.3699
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0108 0.0814 0.3734
Loa Loa (eye worm) RNA binding protein 0.0065 0.0459 0.0942
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0058 0.0058
Onchocerca volvulus Peroxidasin homolog 0.0437 0.357 1
Brugia malayi AMP-binding enzyme family protein 0.0063 0.044 0.1059
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0018 0.0067 0.0563
Echinococcus multilocularis bloom syndrome protein 0.0025 0.0123 0.0123
Loa Loa (eye worm) oxidoreductase 0.0018 0.0067 0.0137
Schistosoma mansoni smad1 5 8 and 0.0016 0.0048 0.0048
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0148 0.1156 0.1156
Onchocerca volvulus 0.0012 0.0015 0.0041
Loa Loa (eye worm) hypothetical protein 0.0019 0.0074 0.0151
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0047 0.0307 0.0307
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.007 0.05 0.2295
Schistosoma mansoni ferritin light chain 0.0034 0.0197 0.0197
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0152 0.1189 1
Mycobacterium ulcerans acetyl-CoA synthetase 0.0018 0.0067 0.0563
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0081 0.0589 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0071 0.0247
Loa Loa (eye worm) hypothetical protein 0.0437 0.357 0.7323
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0306 0.2577
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0019 0.0068 0.0062
Loa Loa (eye worm) hypothetical protein 0.0055 0.0377 0.0773
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0016 0.0044 0.0107
Brugia malayi nuclear receptor NHR-88 0.0019 0.0074 0.0178
Loa Loa (eye worm) hypothetical protein 0.0013 0.0019 0.0039
Schistosoma mansoni hypothetical protein 0.0099 0.0738 0.0738
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0019 0.0068 0.0573
Trichomonas vaginalis glucosylceramidase, putative 0.0451 0.3687 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0019 0.0074 0.0074
Loa Loa (eye worm) phosphatidylinositol 3 0.0047 0.0307 0.0629
Onchocerca volvulus 0.0437 0.357 1
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0018 0.0067 0.0307
Schistosoma mansoni nAChR subunit 0.0013 0.0019 0.0019
Schistosoma mansoni thyroid hormone receptor 0.0168 0.1318 0.1318
Giardia lamblia GTOR 0.0047 0.0307 0.1215
Brugia malayi prolyl oligopeptidase family protein 0.0028 0.015 0.0361
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0058 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0019 0.0074 0.0178
Brugia malayi excitatory GABA receptor EXP-1A 0.0013 0.0019 0.0046
Loa Loa (eye worm) latrophilin receptor protein 2 0.0099 0.0738 0.1514
Echinococcus granulosus GTP binding nuclear protein Ran 0.0041 0.0254 0.0254
Echinococcus granulosus ecdysone induced protein 78C 0.0019 0.0074 0.0074
Echinococcus multilocularis muscleblind protein 1 0.0145 0.1128 0.1128
Echinococcus granulosus expressed conserved protein 0.0094 0.0696 0.0696
Plasmodium falciparum cysteine proteinase falcipain 3 0.0012 0.0015 0.0091
Trichomonas vaginalis replication factor C large subunit, putative 0.0011 0.00000023581 0.00000063951
Brugia malayi Latrophilin receptor protein 2 0.0099 0.0738 0.1777
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0019 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0116 0.0887 0.1819
Giardia lamblia NADH oxidase lateral transfer candidate 0.007 0.05 0.1981
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0047 0.0307 0.1348
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0047 0.0307 0.1348
Giardia lamblia Alanyl dipeptidyl peptidase 0.0028 0.015 0.0593
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.027 0.027
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0019 0.0068 0.014
Loa Loa (eye worm) hypothetical protein 0.0063 0.044 0.0902
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0053 0.0242
Onchocerca volvulus 0.0018 0.0067 0.0187
Leishmania major hypothetical protein, conserved 0.0016 0.0043 0.013
Mycobacterium ulcerans dehydrogenase 0.0019 0.0068 0.0573
Leishmania major hypothetical protein, conserved 0.0019 0.0068 0.0247
Plasmodium falciparum importin beta, putative 0.0055 0.0377 0.2341
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0312 0.2526 0.685
Brugia malayi MH2 domain containing protein 0.0016 0.0048 0.0116
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.007 0.05 0.3108
Schistosoma mansoni hypothetical protein 0.0099 0.0738 0.0738
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0012 0.0015 0.0015
Trichomonas vaginalis importin beta-1, putative 0.0045 0.0289 0.0784
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.007 0.05 0.3108
Echinococcus granulosus tumor protein p63 0.0342 0.2778 0.2778
Onchocerca volvulus Cathepsin F homolog 0.0012 0.0015 0.0041
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0019 0.0074 0.0074
Echinococcus granulosus Protein patched homolog 1 0.0043 0.027 0.027
Loa Loa (eye worm) Smad1 0.0016 0.0048 0.0099
Brugia malayi Animal haem peroxidase family protein 0.0437 0.357 0.8598
Plasmodium falciparum thioredoxin reductase 0.0203 0.161 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0019 0.0039
Loa Loa (eye worm) hypothetical protein 0.0013 0.0019 0.0039
Giardia lamblia Thioredoxin reductase 0.0019 0.0068 0.027
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0028 0.015 0.015
Trichomonas vaginalis glucosylceramidase, putative 0.0296 0.2389 0.6479
Brugia malayi MH2 domain containing protein 0.0238 0.191 0.46
Trypanosoma brucei oligopeptidase b 0.0108 0.0814 0.3734
Loa Loa (eye worm) phosphatidylinositol 3 0.0016 0.0044 0.0091
Trichomonas vaginalis glucosylceramidase, putative 0.0296 0.2389 0.6479
Loa Loa (eye worm) hypothetical protein 0.0116 0.0887 0.1819
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0019 0.0068 0.0062
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0019 0.0068 0.0313
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0019 0.0074 0.0151
Echinococcus multilocularis protein dispatched 1 0.0049 0.0321 0.0321
Echinococcus multilocularis Smad4 0.0016 0.0048 0.0048
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0303 0.1392
Leishmania major DNA polymerase kappa, putative 0.0014 0.003 0.0072
Echinococcus granulosus dna polymerase eta 0.0033 0.0187 0.0187
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0078 0.0564 0.1968
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0116 0.0887 0.1402
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0028 0.015 0.0406
Brugia malayi Papain family cysteine protease containing protein 0.0012 0.0015 0.0035
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0019 0.0074 0.0151
Brugia malayi hypothetical protein 0.0437 0.357 0.8598
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0012 0.0015 0.004
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0019 0.0068 0.0238
Loa Loa (eye worm) steroid hormone receptor 0.0019 0.0074 0.0151
Loa Loa (eye worm) hypothetical protein 0.0013 0.0019 0.0039
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0019 0.0068 0.0313
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.007 0.05 0.8496
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0105 0.0105
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0019 0.0068 0.0313
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0018 0.0067 0.006
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0012 0.0015 0.004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0303 0.1392
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0125 0.0339
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0013 0.0019 0.0039
Plasmodium falciparum thioredoxin reductase 0.007 0.05 0.3108
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0303 0.1392
Leishmania major dihydrolipoamide dehydrogenase, putative 0.007 0.05 0.2243
Entamoeba histolytica prolyl oligopeptidase family protein 0.0028 0.015 0.0523
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0089 0.0182
Loa Loa (eye worm) ACC-1 protein 0.0013 0.0019 0.0039
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0303 0.1392
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0019 0.0074 0.0178
Entamoeba histolytica deoxycytidyl transferase, putative 0.0014 0.003 0.0106
Echinococcus multilocularis expressed conserved protein 0.0094 0.0696 0.0696
Brugia malayi RNA binding protein 0.0065 0.0459 0.1106
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0116 0.0887 0.2135
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.015 0.0687

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 0.03 Minimum inhibitory concentration required against S. aureus SA-1199, wild-type isolate ChEMBL. 12798315
MIC (functional) = 0.03 Minimum inhibitory concentration required against S. aureus SA 1199B, constitutively overexpresses norA and harbors a topoisomerase IV A subunit substitution (A116E) ChEMBL. 12798315
MIC (functional) = 0.06 Minimum inhibitory concentration required against S. aureus SA 1199-3, laboratory-derived mutant of SA 1199 that inducibly overexpresses norA, no gyrase or topoisomerase IV mutations ChEMBL. 12798315
MIC (functional) = 0.125 Minimum inhibitory concentration required against S. aureus MRSA 494, methicillin resistant SA isolate ChEMBL. 12798315
MIC (functional) > 16 Minimum inhibitory concentration required against S. aureus GISA 992, vancomycin-insensitive SA. ChEMBL. 12798315

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.