Detailed information for compound 1340950

Basic information

Technical information
  • TDR Targets ID: 1340950
  • Name: 1-[4-(furan-2-carbonyl)piperazin-1-yl]-2-[(5- furan-2-yl-4-phenyl-1,2,4-triazol-3-yl)sulfan yl]ethanone
  • MW: 463.509 | Formula: C23H21N5O4S
  • H donors: 0 H acceptors: 4 LogP: 2.55 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCN(CC1)C(=O)c1ccco1)CSc1nnc(n1c1ccccc1)c1ccco1
  • InChi: 1S/C23H21N5O4S/c29-20(26-10-12-27(13-11-26)22(30)19-9-5-15-32-19)16-33-23-25-24-21(18-8-4-14-31-18)28(23)17-6-2-1-3-7-17/h1-9,14-15H,10-13,16H2
  • InChiKey: ZQHGSJJZXUJYTM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[4-(furan-2-carbonyl)piperazin-1-yl]-2-[[5-(2-furyl)-4-phenyl-1,2,4-triazol-3-yl]sulfanyl]ethanone
  • 1-[4-(2-furyl-oxomethyl)-1-piperazinyl]-2-[[5-(2-furyl)-4-phenyl-1,2,4-triazol-3-yl]thio]ethanone
  • 1-[4-(furan-2-carbonyl)piperazin-1-yl]-2-[[5-(2-furyl)-4-phenyl-1,2,4-triazol-3-yl]thio]ethanone
  • 1-(4-furan-2-ylcarbonylpiperazin-1-yl)-2-[(5-furan-2-yl-4-phenyl-1,2,4-triazol-3-yl)sulfanyl]ethanone
  • MLS000048836
  • SMR000062580
  • T0515-2634
  • MLS000881086
  • Oprea1_255336
  • ZINC03294844

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens glutaminase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Loa Loa (eye worm) glutaminase 2 Get druggable targets OG5_129245 All targets in OG5_129245
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Brugia malayi glutaminase DH11.1 Get druggable targets OG5_129245 All targets in OG5_129245
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium ulcerans glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis glutaminase, putative Get druggable targets OG5_129245 All targets in OG5_129245
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei protein kinase, putative 0.0101 0.0571 0.316
Plasmodium vivax amine transporter, putative 0.0025 0.0097 0.1727
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0061 0.0318 0.0539
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0143 0.0839 0.0998
Loa Loa (eye worm) hypothetical protein 0.0086 0.0481 0.0814
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0084 0.0388
Loa Loa (eye worm) hypothetical protein 0.0018 0.0051 0.0087
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0184 0.1098 0.184
Brugia malayi MH2 domain containing protein 0.0033 0.0144 0.0243
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0025 0.0097 0.0164
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0101 0.0571 0.316
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0257 0.7885
Echinococcus multilocularis tar DNA binding protein 0.0129 0.0749 0.0749
Trichomonas vaginalis glucosylceramidase, putative 0.0541 0.3344 0.5654
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.008 0.0485
Trichomonas vaginalis esterase, putative 0.0072 0.0388 0.0633
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0269 0.032
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.0028 0.0028
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.002 0.0008
Echinococcus granulosus tumor protein p63 0.0408 0.2508 0.2984
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0017
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.002 0.0008
Entamoeba histolytica hypothetical protein 0.0023 0.0081 0.0132
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.008 0.0485
Echinococcus granulosus TGF beta signal transducer SmadC 0.0033 0.0144 0.0171
Onchocerca volvulus 0.0025 0.0097 0.0164
Schistosoma mansoni chromatin regulatory protein sir2 0.002 0.006 0.0072
Trichomonas vaginalis glucosylceramidase, putative 0.0782 0.4864 0.8236
Trypanosoma cruzi hypothetical protein, conserved 0.0292 0.1776 1
Loa Loa (eye worm) nuclear factor I 0.0018 0.0051 0.0087
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.0388 0.0657
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0023 0.008 0.0109
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0388 0.2116
Loa Loa (eye worm) hypothetical protein 0.0025 0.0097 0.0164
Echinococcus multilocularis zinc finger protein 0.0041 0.0198 0.0198
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.0819 0.0974
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.008 0.0109
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0023 0.008 0.0109
Loa Loa (eye worm) RecQ helicase 0.0023 0.0084 0.0142
Leishmania major DNA polymerase eta, putative 0.0023 0.0084 0.0388
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.0035 0.011
Echinococcus granulosus dna polymerase eta 0.0023 0.0084 0.0099
Loa Loa (eye worm) hypothetical protein 0.0025 0.0097 0.0164
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.002 0.0008
Loa Loa (eye worm) hypothetical protein 0.0023 0.008 0.0135
Trichomonas vaginalis CMGC family protein kinase 0.0101 0.0571 0.0945
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.002 0.006 0.0072
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0947 0.5902 1
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0059 0.0307 0.0464
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0084 0.0388
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0307 0.0495
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0062 0.0325 0.1758
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.008 0.008
Schistosoma mansoni smad1 5 8 and 0.0033 0.0144 0.0171
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.008 0.0485
Schistosoma mansoni glutaminase 0.033 0.2017 0.24
Toxoplasma gondii GAF domain-containing protein 0.0059 0.0307 0.2954
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0025 0.0097 0.0097
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0257 0.1372
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0184 0.1098 0.184
Toxoplasma gondii ABC1 family protein 0.0072 0.0388 0.3832
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0388 0.0633
Trichomonas vaginalis glucosylceramidase, putative 0.0782 0.4864 0.8236
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0184 0.1098 0.6153
Schistosoma mansoni importin beta-1 0.0028 0.0115 0.0137
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0302 0.1838 0.3115
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0123 0.0714 0.0849
Trichomonas vaginalis glucosylceramidase, putative 0.0782 0.4864 0.8236
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.002 0.006 0.0257
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0023 0.008 0.1237
Trypanosoma brucei unspecified product 0.0016 0.0038 0.013
Toxoplasma gondii hypothetical protein 0.0025 0.0097 0.0673
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0066 0.1942
Echinococcus granulosus mothers against decapentaplegic 5 0.0033 0.0144 0.0171
Schistosoma mansoni hypothetical protein 0.052 0.3211 0.3822
Trypanosoma brucei Silent information regulator 2 related protein 1 0.002 0.006 0.0257
Brugia malayi Smad1 0.0033 0.0144 0.0243
Trichomonas vaginalis conserved hypothetical protein 0.0162 0.0956 0.1597
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0061 0.0318 0.1722
Trichomonas vaginalis CAMK family protein kinase 0.0058 0.0301 0.0486
Loa Loa (eye worm) glutaminase 2 0.033 0.2017 0.3417
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0023 0.008 0.0365
Loa Loa (eye worm) MH1 domain-containing protein 0.0033 0.0144 0.0243
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0023 0.008 0.0095
Trichomonas vaginalis helicase, putative 0.0013 0.002 0.0008
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0053 0.0063
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.015 0.088 0.1047
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0947 0.5902 1
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0023 0.008 0.1237
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0025 0.0097 0.0164
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0947 0.5902 1
Schistosoma mansoni eyes absent homolog 0.0088 0.0488 0.0581
Loa Loa (eye worm) hypothetical protein 0.0028 0.0115 0.0195
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0023 0.008 0.0135
Mycobacterium ulcerans NAD-dependent deacetylase 0.0062 0.0325 0.0494
Loa Loa (eye worm) TAR-binding protein 0.0129 0.0749 0.1269
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0023 0.008 0.0109
Brugia malayi hypothetical protein 0.0051 0.0257 0.0435
Echinococcus granulosus tar DNA binding protein 0.0129 0.0749 0.0891
Echinococcus multilocularis dna polymerase eta 0.0023 0.0084 0.0084
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0154 0.0183
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.002 0.006 0.006
Trichomonas vaginalis CAMK family protein kinase 0.0058 0.0301 0.0486
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.008 0.0485
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0115 0.0115
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0084 0.0142
Brugia malayi RNA recognition motif domain containing protein 0.0129 0.0749 0.1269
Schistosoma mansoni hypothetical protein 0.0143 0.0839 0.0998
Mycobacterium ulcerans glutaminase 0.033 0.2017 0.3378
Schistosoma mansoni hypothetical protein 0.0309 0.1886 0.2245
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0023 0.008 0.0095
Loa Loa (eye worm) CYP4Cod1 0.0016 0.0035 0.0059
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0084 0.0116
Schistosoma mansoni chromatin regulatory protein sir2 0.002 0.006 0.0072
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.002 0.0008
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0947 0.5902 1
Echinococcus multilocularis GPCR, family 2 0.0143 0.0839 0.0839
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0023 0.008 0.0365
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0023 0.008 0.008
Trypanosoma cruzi ISWI complex protein 0.003 0.0124 0.062
Brugia malayi PHD-finger family protein 0.0052 0.0263 0.0446
Schistosoma mansoni hypothetical protein 0.0023 0.008 0.0096
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0081 0.045 0.0535
Schistosoma mansoni Smad4 0.0015 0.0029 0.0035
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.0229 0.0229
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0084 0.0388
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.002 0.006 0.0077
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0025 0.0097 0.0115
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0084 0.0084
Onchocerca volvulus 0.0072 0.0388 0.0657
Echinococcus granulosus smad 0.0033 0.0144 0.0171
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0184 0.1098 0.1098
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0947 0.5902 1
Loa Loa (eye worm) hypothetical protein 0.015 0.088 0.149
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.002 0.0008
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0084 0.0116
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0062 0.0325 0.0526
Loa Loa (eye worm) transcriptional regulator 0.002 0.006 0.0102
Toxoplasma gondii hypothetical protein 0.0162 0.0956 1
Giardia lamblia Kinase, CMGC CLK 0.0061 0.0318 0.0441
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.002 0.006 0.0077
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0023 0.008 0.0095
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0184 0.1098 0.184
Schistosoma mansoni DNA polymerase eta 0.0023 0.0084 0.0099
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0084 0.0388
Mycobacterium tuberculosis Conserved protein 0.0072 0.0388 0.0764
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0038 0.013
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0126 0.0728 0.4051
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0184 0.1098 0.184
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0028 0.0033
Schistosoma mansoni cpg binding protein 0.0065 0.0347 0.0413
Trypanosoma brucei polo-like protein kinase 0.0115 0.0664 0.3685
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0115 0.0664 0.079
Loa Loa (eye worm) MH2 domain-containing protein 0.0015 0.0029 0.005
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0023 0.008 0.0365
Schistosoma mansoni tar DNA-binding protein 0.0129 0.0749 0.0891
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0081 0.045 0.045
Loa Loa (eye worm) hypothetical protein 0.0081 0.045 0.0762
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0084 0.0388
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.0664 0.1102
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0269 0.032
Echinococcus granulosus dual specificity protein kinase clk2 0.0061 0.0318 0.0379
Loa Loa (eye worm) solute carrier family 6 member 4 0.015 0.088 0.149
Loa Loa (eye worm) MH1 domain-containing protein 0.0015 0.0029 0.005
Echinococcus granulosus mothers against decapentaplegic 2 0.0015 0.0029 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0184 0.1098 0.184
Brugia malayi MH2 domain containing protein 0.0482 0.2974 0.5039
Schistosoma mansoni smad1 5 8 and 0.0033 0.0144 0.0171
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.012 0.069 0.069
Brugia malayi transcriptional regulator, Sir2 family protein 0.002 0.006 0.0102
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.0819 0.0974
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0184 0.1098 0.184
Echinococcus multilocularis cpg binding protein 0.0065 0.0347 0.0347
Loa Loa (eye worm) norepinephrine transporter 0.015 0.088 0.149
Brugia malayi beta-lactamase family protein 0.0072 0.0388 0.0657
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0184 0.1098 0.184
Schistosoma mansoni myst-related protein 0.0011 0.0003 0.0004
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0059 0.0307 0.0561
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0947 0.5902 1
Echinococcus granulosus hypothetical protein 0.0059 0.0307 0.0366
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0388 0.2116
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0184 0.1098 0.184
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0782 0.4864 0.8241
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0062 0.0325 1
Schistosoma mansoni hypothetical protein 0.0282 0.1711 0.2036
Loa Loa (eye worm) sirtuin 4 0.002 0.006 0.0102
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0084 0.0142
Echinococcus granulosus serotonin transporter 0.015 0.088 0.1047
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0025 0.0097 0.0673
Loa Loa (eye worm) hypothetical protein 0.0072 0.0388 0.0657
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.0664 0.1102
Leishmania major hypothetical protein, conserved 0.0072 0.0388 0.2116
Trichomonas vaginalis glucosylceramidase, putative 0.0513 0.317 0.5358
Trichomonas vaginalis CMGC family protein kinase 0.0101 0.0571 0.0945
Loa Loa (eye worm) hypothetical protein 0.0079 0.0436 0.0739
Brugia malayi Latrophilin receptor protein 2 0.0143 0.0839 0.1422
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0257 0.1372
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0184 0.1098 0.184
Onchocerca volvulus Glucosylceramidase homolog 0.0513 0.317 0.537
Schistosoma mansoni serine/threonine protein kinase 0.0061 0.0318 0.0379
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0115 0.0566
Schistosoma mansoni hypothetical protein 0.0828 0.5154 0.6133
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0947 0.5902 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0184 0.1098 0.6153
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0184 0.1098 0.184
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0081 0.0112
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.008 0.0485
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0184 0.1098 0.184
Schistosoma mansoni bromodomain containing protein 0.0126 0.0734 0.0873
Trichomonas vaginalis glucosylceramidase, putative 0.0513 0.317 0.5358
Leishmania major hypothetical protein, conserved 0.0292 0.1776 1
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0062 0.0325 0.1758
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.0819 0.0974
Onchocerca volvulus 0.0072 0.0388 0.0657
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0101 0.0571 0.316
Loa Loa (eye worm) transcriptional regulator 0.002 0.006 0.0102
Loa Loa (eye worm) hypothetical protein 0.0309 0.1886 0.3196
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0078 0.0428 0.0428
Schistosoma mansoni tar DNA-binding protein 0.0129 0.0749 0.0891
Schistosoma mansoni sodium/chloride dependent transporter 0.0025 0.0097 0.0115
Onchocerca volvulus 0.0058 0.0303 0.0513
Entamoeba histolytica serine/threonine protein kinase, putative 0.0115 0.0664 0.112
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0023 0.008 0.237
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0183 0.1087 0.1087
Entamoeba histolytica hypothetical protein 0.0097 0.0548 0.0923
Schistosoma mansoni myst-related protein 0.0011 0.0003 0.0004
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0947 0.5902 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0023 0.008 0.0135
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0035 0.0059
Mycobacterium ulcerans hypothetical protein 0.0072 0.0388 0.0602
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0062 0.0325 0.1758
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0655 0.4063 1
Giardia lamblia Hypothetical protein 0.0023 0.008 0.0033
Leishmania major cAMP-specific phosphodiesterase, putative 0.0023 0.008 0.0365
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0023 0.008 0.0109
Loa Loa (eye worm) hypothetical protein 0.015 0.088 0.149
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.002 0.006 0.0097
Schistosoma mansoni sodium/chloride dependent transporter 0.0027 0.0108 0.0128
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0084 0.0099
Trichomonas vaginalis CMGC family protein kinase 0.0101 0.0571 0.0945
Schistosoma mansoni transcription factor LCR-F1 0.0078 0.0428 0.051
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.0388 0.0602
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0038 0.013
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0115 0.0664 0.3685
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0025 0.0097 0.0673
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0183 0.1087 0.1293
Loa Loa (eye worm) hypothetical protein 0.0072 0.0388 0.0657
Mycobacterium tuberculosis Conserved protein 0.0072 0.0388 0.0764
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0025 0.0097 0.0164
Trichomonas vaginalis glucosylceramidase, putative 0.0782 0.4864 0.8236
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0023 0.008 0.0135
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0257 0.6276
Schistosoma mansoni smad 0.0015 0.0029 0.0035
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0081 0.045 0.0762
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0257 0.1372
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.0819 0.0974
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0062 0.0325 0.0545
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0023 0.008 0.0095
Echinococcus multilocularis microtubule associated protein 2 0.1344 0.8403 0.8403
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0028 0.0033
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.0229 0.0272
Trypanosoma cruzi polo-like protein kinase, putative 0.0115 0.0664 0.3685
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0154 0.0183
Plasmodium falciparum transcriptional regulatory protein sir2b 0.002 0.006 0.1776
Brugia malayi hypothetical protein 0.0025 0.0097 0.0164
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0184 0.1098 0.184
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0453 0.2788 0.4724
Brugia malayi CXXC zinc finger family protein 0.0058 0.0303 0.0513
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0023 0.008 0.0109
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.008 0.0365
Mycobacterium ulcerans Sir2-like regulatory protein 0.002 0.006 0.0044
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0269 0.0269
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0084 0.0388
Echinococcus granulosus fetal alzheimer antigen falz 0.0047 0.0234 0.0279
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0229 0.0272
Echinococcus granulosus snurportin 1 0.0302 0.1838 0.2188
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.008 0.0485
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0023 0.008 0.008
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0023 0.008 0.0095
Loa Loa (eye worm) serotonin transporter b 0.015 0.088 0.149
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0184 0.1098 0.184
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0184 0.1098 0.184
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0184 0.1098 0.184
Leishmania major protein kinase, putative 0.0061 0.0318 0.1722
Loa Loa (eye worm) transcription factor SMAD2 0.0482 0.2974 0.5039
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0023 0.008 0.0095
Echinococcus granulosus geminin 0.052 0.3211 0.3822
Brugia malayi MH2 domain containing protein 0.0033 0.0144 0.0243
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0025 0.0097 0.0115
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0023 0.008 0.237
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0101 0.0571 0.5828
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0025 0.0097 0.0673
Onchocerca volvulus 0.0046 0.0229 0.0387
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.008 0.0485
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0257 0.7885
Leishmania major hypothetical protein, conserved 0.0051 0.0257 0.1372
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.005 0.005
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0388 0.2116
Mycobacterium leprae Probable lipase LipE 0.0072 0.0388 1
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0313 0.0373
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.002 0.0008
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0059 0.0307 0.0561
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.002 0.006 0.006
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0084 0.0142
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0084 0.0099
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0081 0.0112
Trypanosoma brucei SIR2-like protein 4, putative 0.002 0.006 0.0257
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.008 0.0365
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0015 0.0029 0.005
Loa Loa (eye worm) hypothetical protein 0.0015 0.0029 0.005
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0084 0.0388
Loa Loa (eye worm) hypothetical protein 0.0072 0.0388 0.0657
Loa Loa (eye worm) hypothetical protein 0.0023 0.008 0.0135
Loa Loa (eye worm) hypothetical protein 0.0088 0.0488 0.0827
Loa Loa (eye worm) hypothetical protein 0.0023 0.008 0.0135
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0101 0.0571 0.316
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0023 0.008 0.0095
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0184 0.1098 0.184
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.008 0.0096
Echinococcus multilocularis serotonin transporter 0.015 0.088 0.088
Loa Loa (eye worm) MBCTL1 0.0053 0.0269 0.0456
Schistosoma mansoni kinase 0.0059 0.0311 0.037
Brugia malayi Cytochrome P450 family protein 0.0016 0.0035 0.0059
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0061 0.0318 0.1722
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0388 0.0633
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0084 0.0116
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0025 0.0097 0.0115
Loa Loa (eye worm) hypothetical protein 0.0072 0.0388 0.0657
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0184 0.1098 0.184
Echinococcus multilocularis dnaJ subfamily B 0.0828 0.5154 0.5154
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0457 0.2818 0.687
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.0388 0.0764
Trypanosoma brucei unspecified product 0.0016 0.0038 0.013
Brugia malayi Importin beta-1 subunit 0.0028 0.0115 0.0195
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0947 0.5902 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0023 0.008 0.008
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.002 0.0008
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0072 0.0122
Brugia malayi NAD-dependent deacetylase SIRT1 0.002 0.006 0.0102
Echinococcus multilocularis Smad4 0.0033 0.0144 0.0144
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0947 0.5902 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0081 0.045 0.0762
Toxoplasma gondii hypothetical protein 0.0059 0.0307 0.2954
Onchocerca volvulus Serine\/threonine kinase homolog 0.0115 0.0664 0.1125
Loa Loa (eye worm) hypothetical protein 0.0088 0.0488 0.0827
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0084 0.0084
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.0388 0.0388
Brugia malayi transcriptional regulator, Sir2 family protein 0.002 0.006 0.0102
Echinococcus multilocularis smad 0.0033 0.0144 0.0144
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.0388 0.0657
Mycobacterium ulcerans lipase LipD 0.0072 0.0388 0.0602
Schistosoma mansoni microtubule-associated protein tau 0.1344 0.8403 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0084 0.0388
Loa Loa (eye worm) hypothetical protein 0.0453 0.2788 0.4724
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0269 0.0269
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0025 0.0097 0.0115
Echinococcus multilocularis mothers against decapentaplegic 5 0.0033 0.0144 0.0144
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0081 0.0112
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0292 0.1776 0.299
Leishmania major hypothetical protein, conserved 0.0023 0.008 0.0365
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.0388 0.0461
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0101 0.0571 0.316
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0303 0.0513
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0084 0.0388
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0292 0.1776 1
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.002 0.006 0.0072
Brugia malayi beta-lactamase 0.0072 0.0388 0.0657
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.0819 0.0819
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.008 0.0485
Trypanosoma cruzi ISWI complex protein 0.003 0.0124 0.062
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0023 0.008 0.008
Echinococcus granulosus GPCR family 2 0.0143 0.0839 0.0998
Loa Loa (eye worm) MH2 domain-containing protein 0.0482 0.2974 0.5039
Plasmodium falciparum importin beta, putative 0.0028 0.0115 0.3469
Toxoplasma gondii histone deacetylase SIR2 0.0062 0.0325 0.3148
Trichomonas vaginalis glutaminase, putative 0.033 0.2017 0.34
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0388 0.0461
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.014 0.0819 0.1387
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.0229 0.0272
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0025 0.0097 0.0115
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.008 0.0365
Entamoeba histolytica hypothetical protein 0.0078 0.0428 0.072
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.0388 0.0764
Loa Loa (eye worm) histone methyltransferase 0.0018 0.005 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.002 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.002 0.0008
Trichomonas vaginalis glucosylceramidase, putative 0.0782 0.4864 0.8236
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0115 0.0566
Schistosoma mansoni hypothetical protein 0.0302 0.1838 0.2188
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0115 0.0869
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.008 0.0485
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0143 0.0839 0.0839
Entamoeba histolytica hypothetical protein, conserved 0.002 0.006 0.0097
Plasmodium falciparum phosphodiesterase delta, putative 0.0023 0.008 0.237
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0184 0.1098 0.184
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.0388 0.0764
Entamoeba histolytica recQ family helicase, putative 0.0012 0.0015 0.002
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0025 0.0097 0.0164
Loa Loa (eye worm) RNA binding protein 0.0129 0.0749 0.1269
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.0388 0.0764
Echinococcus multilocularis 0.0059 0.0307 0.0307
Loa Loa (eye worm) hypothetical protein 0.0138 0.0804 0.1362
Brugia malayi mothers against decapentaplegic homolog 3 0.0015 0.0029 0.005
Toxoplasma gondii histone lysine methyltransferase SET1 0.0115 0.066 0.6787
Plasmodium vivax NAD-dependent deacetylase, putative 0.0062 0.0325 0.8209
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0047 0.0234 0.0234
Giardia lamblia hypothetical protein 0.0023 0.008 0.0033
Loa Loa (eye worm) hypothetical protein 0.0059 0.0307 0.0521
Trichomonas vaginalis glucosylceramidase, putative 0.0513 0.317 0.5358
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0023 0.008 0.0365
Schistosoma mansoni chromatin regulatory protein sir2 0.002 0.006 0.0072
Schistosoma mansoni chromatin regulatory protein sir2 0.0062 0.0325 0.0386
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0081 0.0375
Leishmania major silent information regulator 2, putative 0.002 0.006 0.0257
Mycobacterium ulcerans beta-lactamase 0.0072 0.0388 0.0602
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0084 0.0099
Echinococcus granulosus dnaJ subfamily B 0.0828 0.5154 0.6133
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0184 0.1098 0.6153
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0101 0.0571 0.0968
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0023 0.008 0.0365
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0084 0.0388
Plasmodium vivax phosphodiesterase gamma, putative 0.0023 0.008 0.1237
Schistosoma mansoni hypothetical protein 0.0143 0.0839 0.0998
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0084 0.0388
Plasmodium falciparum amino acid transporter, putative 0.0025 0.0097 0.2907
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0101 0.0571 0.316
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0023 0.008 0.0095
Plasmodium vivax importin-beta 2, putative 0.0028 0.0115 0.2241
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0035 0.0059
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.0819 0.0974
Loa Loa (eye worm) hypothetical protein 0.0072 0.0388 0.0657
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0023 0.008 0.0033
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0154 0.0154
Echinococcus granulosus dna polymerase kappa 0.0023 0.0084 0.0099
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0084 0.0136
Brugia malayi MH1 domain containing protein 0.0018 0.0051 0.0087
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0947 0.5902 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0143 0.0839 0.1422
Plasmodium vivax serine/threonine kinase-1, putative 0.0061 0.0318 0.8027
Toxoplasma gondii hypothetical protein 0.0059 0.0307 0.2954
Schistosoma mansoni hypothetical protein 0.003 0.0124 0.0148
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.002 0.006 0.0077
Brugia malayi hypothetical protein 0.0088 0.0488 0.0827
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0257 0.241
Echinococcus granulosus cpg binding protein 0.0065 0.0347 0.0413
Loa Loa (eye worm) hypothetical protein 0.0059 0.0307 0.052
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.008 0.0485
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0084 0.0083
Schistosoma mansoni Smad4 0.0033 0.0144 0.0171
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.0664 0.1102
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0184 0.1098 0.184
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0061 0.0318 0.3078
Brugia malayi MH2 domain containing protein 0.0015 0.0029 0.005
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0033 0.0144 0.0171
Schistosoma mansoni sodium/chloride dependent transporter 0.015 0.088 0.1047
Echinococcus granulosus chromatin regulatory protein sir2 0.002 0.006 0.0072
Leishmania major sir2-family protein-like protein 0.002 0.006 0.0257
Brugia malayi hypothetical protein 0.0033 0.0143 0.0243
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.008 0.0365
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.0819 0.0819
Leishmania major hypothetical protein, conserved 0.003 0.0124 0.062
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0388 0.0633
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0023 0.008 0.0095
Schistosoma mansoni tar DNA-binding protein 0.0129 0.0749 0.0891
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0084 0.0388
Trichomonas vaginalis glucosylceramidase, putative 0.0541 0.3344 0.5654
Loa Loa (eye worm) hypothetical protein 0.002 0.006 0.0102
Leishmania major hypothetical protein, conserved 0.0023 0.008 0.0365
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.0229 0.0387
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.002 0.006 0.006
Plasmodium falciparum GAF domain-related protein, putative 0.0059 0.0307 0.9443
Giardia lamblia DINP protein human, muc B family 0.0023 0.0084 0.004
Echinococcus multilocularis mothers against decapentaplegic 6 0.0015 0.0029 0.0029
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.0229 0.0229
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.0229 0.0272
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0062 0.0325 0.0526
Schistosoma mansoni smad1 5 8 and 0.0033 0.0144 0.0171
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0084 0.0388
Brugia malayi MH1 domain containing protein 0.0018 0.0051 0.0087
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0184 0.1098 0.184
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0101 0.0571 0.316
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0033 0.0146 0.0146
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0061 0.0318 0.1722
Entamoeba histolytica hypothetical protein 0.0078 0.0428 0.072
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0023 0.008 0.0095
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0062 0.0325 0.0606
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0084 0.0388
Schistosoma mansoni hypothetical protein 0.052 0.3211 0.3822
Echinococcus granulosus Smad4 0.0033 0.0144 0.0171
Brugia malayi RNA binding protein 0.0129 0.0749 0.1269
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0038 0.013
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0028 0.0028
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0129 0.0749 0.1269
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.002 0.006 0.0077
Schistosoma mansoni sodium-dependent amino acid transporter 0.0025 0.0097 0.0115
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.0664 0.1102
Loa Loa (eye worm) PHD-finger family protein 0.004 0.019 0.0322
Loa Loa (eye worm) hypothetical protein 0.015 0.088 0.149
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.0388 0.0764
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0023 0.008 0.0095
Loa Loa (eye worm) hypothetical protein 0.006 0.0313 0.053
Brugia malayi serine/threonine-protein kinase plk-2 0.0115 0.0664 0.1125
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0061 0.0318 0.1722
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0023 0.008 0.1237
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.008 0.0485
Brugia malayi MH1 domain containing protein 0.0033 0.0144 0.0243
Loa Loa (eye worm) hypothetical protein 0.0072 0.0388 0.0657
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.0664 0.1102
Echinococcus granulosus sodium and chloride dependent glycine 0.0025 0.0097 0.0115
Schistosoma mansoni tar DNA-binding protein 0.0129 0.0749 0.0891
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0061 0.0318 0.1722
Echinococcus granulosus mitogen activated protein kinase 3 0.0101 0.0571 0.068
Schistosoma mansoni smad 0.0033 0.0144 0.0171
Entamoeba histolytica hypothetical protein 0.0078 0.0428 0.072
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.002 0.0008
Echinococcus granulosus zinc finger protein 0.0041 0.0198 0.0235
Echinococcus multilocularis sodium and chloride dependent glycine 0.0025 0.0097 0.0097
Brugia malayi Bromodomain containing protein 0.0075 0.0406 0.0689
Schistosoma mansoni zinc finger protein 0.003 0.0124 0.0148
Plasmodium vivax hypothetical protein, conserved 0.0059 0.0307 0.77
Loa Loa (eye worm) Smad1 0.0033 0.0144 0.0243
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.008 0.0485
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.002 0.0008
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0084 0.0084
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.008 0.0485
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.002 0.006 0.0097
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0269 0.0456
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.007 0.0377 0.0449
Schistosoma mansoni zinc finger protein 0.0041 0.0198 0.0235
Brugia malayi mbt repeat family protein 0.0046 0.0229 0.0387
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.005 0.006
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0388 0.0461
Brugia malayi RNA, U transporter 1 0.008 0.0443 0.0751
Onchocerca volvulus 0.0072 0.0388 0.0657
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0184 0.1098 0.184
Schistosoma mansoni cpg binding protein 0.0065 0.0347 0.0413
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0025 0.0097 0.5
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0084 0.0388
Loa Loa (eye worm) hypothetical protein 0.0075 0.0407 0.069
Echinococcus multilocularis tumor protein p63 0.0408 0.2508 0.2508
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0025 0.0097 0.0097
Schistosoma mansoni serine/threonine protein kinase 0.0061 0.0318 0.0379
Loa Loa (eye worm) transcriptional regulator 0.002 0.006 0.0102
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0184 0.1098 0.184
Brugia malayi transcriptional regulator, Sir2 family protein 0.002 0.006 0.0102
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0341 0.2084 0.3528
Trichomonas vaginalis glucosylceramidase, putative 0.0513 0.317 0.5358
Loa Loa (eye worm) hypothetical protein 0.0046 0.0229 0.0387
Brugia malayi Sodium:neurotransmitter symporter family protein 0.015 0.088 0.149
Leishmania major DNA polymerase kappa, putative 0.0023 0.0084 0.0388
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.002 0.0008
Mycobacterium leprae conserved hypothetical protein 0.0072 0.0388 1
Plasmodium falciparum transporter, putative 0.0025 0.0097 0.2907
Treponema pallidum sodium- and chloride- dependent transporter 0.015 0.088 0.5
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0081 0.045 0.0535
Trichomonas vaginalis conserved hypothetical protein 0.0162 0.0956 0.1597
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.008 0.0485
Trichomonas vaginalis glucosylceramidase, putative 0.0513 0.317 0.5358
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0184 0.1098 0.184
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0115 0.0664 0.0664
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.0664 0.1102
Echinococcus multilocularis chromatin regulatory protein sir2 0.002 0.006 0.006
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0061 0.0318 0.1722
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.008 0.0485
Loa Loa (eye worm) hypothetical protein 0.0051 0.0257 0.0435
Loa Loa (eye worm) hypothetical protein 0.0053 0.0269 0.0456
Trichomonas vaginalis glucosylceramidase, putative 0.0782 0.4864 0.8236
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0023 0.008 0.008
Onchocerca volvulus 0.0025 0.0097 0.0164
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0033 0.0144 0.0144
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0023 0.008 0.0135
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0101 0.0571 0.316
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0025 0.0097 0.0115
Trypanosoma brucei ISWI complex protein 0.003 0.0124 0.062
Loa Loa (eye worm) hypothetical protein 0.0117 0.0676 0.1145
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0184 0.1098 0.1307
Leishmania major importin beta-1 subunit, putative 0.0023 0.0081 0.0375
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.002 0.006 0.0072
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0046 0.0229 0.0387
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0084 0.0388
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0229 0.0272
Loa Loa (eye worm) hypothetical protein 0.0025 0.0097 0.0164
Loa Loa (eye worm) hypothetical protein 0.0143 0.0839 0.1422
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0292 0.1776 0.299
Brugia malayi hypothetical protein 0.0078 0.0428 0.0725
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0184 0.1098 0.1307
Echinococcus granulosus mothers against decapentaplegic 6 0.0015 0.0029 0.0035
Schistosoma mansoni chromatin regulatory protein sir2 0.002 0.006 0.0072
Echinococcus granulosus mitogen activated protein kinase 0.0101 0.0571 0.068
Plasmodium falciparum protein serine/threonine kinase-1 0.0061 0.0318 0.98
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0084 0.0388
Entamoeba histolytica hypothetical protein 0.0078 0.0428 0.072
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0078 0.0428 0.051
Schistosoma mansoni methyl-cpg binding protein mbd 0.0033 0.0146 0.0174
Giardia lamblia Kinase, PLK 0.0115 0.0664 0.1033
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0782 0.4864 0.8241
Loa Loa (eye worm) hypothetical protein 0.0025 0.0097 0.0164
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0126 0.0728 0.1211
Schistosoma mansoni cpg binding protein 0.0058 0.0303 0.0361
Trypanosoma brucei unspecified product 0.0023 0.0084 0.0388
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.012 0.069 0.0821
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0023 0.008 0.0095
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.0035 0.011
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0025 0.0097 0.0164
Onchocerca volvulus 0.0025 0.0097 0.0164
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0081 0.045 0.0738
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0025 0.0097 0.0115
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.002 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.002 0.0008
Loa Loa (eye worm) hypothetical protein 0.0034 0.0154 0.0261
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0023 0.008 0.0095
Onchocerca volvulus 0.006 0.0313 0.053
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0023 0.008 0.0109
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0023 0.008 0.0135
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0184 0.1098 0.184
Trichomonas vaginalis glucosylceramidase, putative 0.0513 0.317 0.5358
Trypanosoma brucei cytochrome P450, putative 0.0016 0.0035 0.011
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.002 0.006 0.006
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0388 0.0633
Echinococcus granulosus importin subunit beta 1 0.0028 0.0115 0.0137
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.007 0.0377 0.0377
Schistosoma mansoni hypothetical protein 0.0143 0.0839 0.0998
Loa Loa (eye worm) hypothetical protein 0.0025 0.0097 0.0164
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0084 0.0083
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0084 0.0388
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0025 0.0097 0.0115
Mycobacterium ulcerans putative regulatory protein 0.0059 0.0307 0.0464
Schistosoma mansoni serine/threonine protein kinase 0.0115 0.0664 0.079
Giardia lamblia Transcriptional regulator, Sir2 family 0.0062 0.0325 0.0452
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0023 0.008 0.237
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0023 0.008 0.237
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0184 0.1098 0.184
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.0388 0.0602
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.002 0.0008
Loa Loa (eye worm) PDE1B protein 0.0023 0.008 0.0135
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.0388 0.0764
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0143 0.0839 0.0839
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0184 0.1098 0.6153
Brugia malayi Cytochrome P450 family protein 0.0016 0.0035 0.0059
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0143 0.0839 0.0998
Plasmodium vivax hypothetical protein, conserved 0.0025 0.0097 0.1727
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0023 0.008 0.0365
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.0388 0.0764
Schistosoma mansoni hypothetical protein 0.0078 0.0428 0.051
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.0571 0.068
Plasmodium falciparum phosphodiesterase gamma, putative 0.0023 0.008 0.237
Brugia malayi TAR-binding protein 0.0129 0.0749 0.1269
Trichomonas vaginalis CMGC family protein kinase 0.0101 0.0571 0.0945
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0084 0.0142
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0453 0.2788 0.4724
Brugia malayi mbt repeat family protein 0.0046 0.0229 0.0387
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.0664 0.1102
Onchocerca volvulus 0.015 0.088 0.149
Brugia malayi Bromodomain containing protein 0.0149 0.0877 0.1487
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.008 0.0365
Schistosoma mansoni hypothetical protein 0.004 0.019 0.0226
Schistosoma mansoni Smad4 0.0015 0.0029 0.0035
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0084 0.0116
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0084 0.0388
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.008 0.0485
Giardia lamblia Kinase, CMGC MAPK 0.0101 0.0571 0.0875
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.002 0.006 0.0077
Brugia malayi MAP kinase sur-1 0.0101 0.0571 0.0968
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0184 0.1098 0.184
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0047 0.0234 0.0279
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0025 0.0097 0.0097
Brugia malayi Protein kinase domain containing protein 0.0061 0.0318 0.0539
Loa Loa (eye worm) bromodomain containing protein 0.0034 0.0153 0.026
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0025 0.0097 0.0115
Echinococcus granulosus sodium and chloride dependent glycine 0.0025 0.0097 0.0115
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0025 0.0097 0.0115
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.002 0.0008
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0023 0.008 0.0109
Loa Loa (eye worm) hypothetical protein 0.0023 0.0084 0.0142
Echinococcus multilocularis mothers against decapentaplegic 2 0.0015 0.0029 0.0029
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.014 0.0819 0.1387
Loa Loa (eye worm) hypothetical protein 0.0025 0.0097 0.0164
Leishmania major protein kinase, putative 0.0061 0.0318 0.1722
Schistosoma mansoni methyl-cpg binding protein mbd 0.0033 0.0146 0.0174
Onchocerca volvulus 0.0947 0.5902 1
Echinococcus multilocularis snurportin 1 0.0302 0.1838 0.1838
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0062 0.0325 0.0526
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0081 0.045 0.0738
Brugia malayi Calcitonin receptor-like protein seb-1 0.0453 0.2788 0.4724
Trichomonas vaginalis glucosylceramidase, putative 0.0513 0.317 0.5358
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0388 1
Mycobacterium tuberculosis Conserved protein 0.0072 0.0388 0.0764
Brugia malayi glutaminase DH11.1 0.033 0.2017 0.3417
Echinococcus multilocularis geminin 0.052 0.3211 0.3211
Echinococcus multilocularis mitogen activated protein kinase 3 0.0101 0.0571 0.0571
Echinococcus granulosus microtubule associated protein 2 0.1344 0.8403 1
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.0028 0.0033
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0388 0.0633
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0023 0.008 0.0109
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0023 0.008 0.0365
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0023 0.008 0.0095
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0025 0.0097 0.0115
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0025 0.0097 0.0115
Echinococcus multilocularis sodium and chloride dependent glycine 0.0025 0.0097 0.0097
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0023 0.008 0.0365
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0184 0.1098 0.184
Loa Loa (eye worm) MH2 domain-containing protein 0.0033 0.0144 0.0243
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0184 0.1098 0.184
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0154 0.0183
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0023 0.008 0.0109
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.0318 0.0515
Mycobacterium ulcerans putative regulatory protein 0.0059 0.0307 0.0464
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0097 0.0548 0.0923
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0023 0.008 0.008
Echinococcus granulosus methyl CpG binding domain protein 2 0.0033 0.0146 0.0174
Plasmodium vivax hypothetical protein, conserved 0.002 0.006 0.0694
Schistosoma mansoni hypothetical protein 0.0143 0.0839 0.0998
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.002 0.006 0.0097
Schistosoma mansoni chromatin regulatory protein sir2 0.002 0.006 0.0072
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.008 0.0485
Toxoplasma gondii hypothetical protein 0.0025 0.0097 0.0673
Brugia malayi latrophilin 2 splice variant baaae 0.0309 0.1886 0.3196
Schistosoma mansoni tar DNA-binding protein 0.0129 0.0749 0.0891
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.002 0.006 0.0077
Trypanosoma cruzi polo-like protein kinase, putative 0.0115 0.0664 0.3685
Giardia lamblia DNA repair protein RAD52 0.0341 0.2084 0.3464
Schistosoma mansoni chromatin regulatory protein sir2 0.002 0.006 0.0072
Loa Loa (eye worm) glutaminase 0.033 0.2017 0.3417
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.002 0.0008
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0269 0.032
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.002 0.006 0.0077
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.008 0.0365
Trichomonas vaginalis conserved hypothetical protein 0.0162 0.0956 0.1597
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0184 0.1098 0.6153
Leishmania major cytochrome p450-like protein 0.0016 0.0035 0.011
Loa Loa (eye worm) latrophilin receptor protein 2 0.0143 0.0839 0.1422
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0023 0.008 0.0109
Loa Loa (eye worm) hypothetical protein 0.0025 0.0097 0.0164
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0062 0.0325 0.1758
Schistosoma mansoni bromodomain containing protein 0.0012 0.001 0.0012
Brugia malayi MH1 domain containing protein 0.0033 0.0144 0.0243
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0023 0.008 0.0485
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0184 0.1098 0.184
Echinococcus granulosus bloom syndrome protein 0.0023 0.0084 0.01
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0081 0.045 0.0738
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0023 0.008 0.0095
Echinococcus multilocularis dual specificity protein kinase clk2 0.0061 0.0318 0.0318
Mycobacterium leprae conserved hypothetical protein 0.0059 0.0307 0.5668
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.002 0.006 0.0257
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0947 0.5902 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.002 0.006 0.0077
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.008 0.0109
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0023 0.008 0.0365
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0126 0.0728 0.1211
Brugia malayi beta-lactamase family protein 0.0072 0.0388 0.0657
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.008 0.0365
Trypanosoma cruzi hypothetical protein, conserved 0.0292 0.1776 1
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0025 0.0097 0.0164
Loa Loa (eye worm) beta-lactamase 0.0072 0.0388 0.0657
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.002 0.006 0.0072
Toxoplasma gondii histone deacetylase SIR2-like 0.002 0.006 0.0278
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0084 0.0388
Echinococcus multilocularis mitogen activated protein kinase 0.0101 0.0571 0.0571
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0115 0.0664 0.1125

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 3.9811 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 9.4662 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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