Detailed information for compound 1345368

Basic information

Technical information
  • TDR Targets ID: 1345368
  • Name: N-(3-chloro-4-methylphenyl)-3-(3,5-dimethyl-4 -piperidin-1-ylsulfonylpyrazol-1-yl)propanami de
  • MW: 438.971 | Formula: C20H27ClN4O3S
  • H donors: 1 H acceptors: 4 LogP: 2.76 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(c(c1)Cl)C)CCn1nc(c(c1C)S(=O)(=O)N1CCCCC1)C
  • InChi: 1S/C20H27ClN4O3S/c1-14-7-8-17(13-18(14)21)22-19(26)9-12-25-16(3)20(15(2)23-25)29(27,28)24-10-5-4-6-11-24/h7-8,13H,4-6,9-12H2,1-3H3,(H,22,26)
  • InChiKey: UCHHMNOFZZCGQS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3-chloro-4-methyl-phenyl)-3-[3,5-dimethyl-4-(1-piperidylsulfonyl)pyrazol-1-yl]propanamide
  • N-(3-chloro-4-methylphenyl)-3-[3,5-dimethyl-4-(1-piperidylsulfonyl)-1-pyrazolyl]propanamide
  • N-(3-chloro-4-methyl-phenyl)-3-(3,5-dimethyl-4-piperidinosulfonyl-pyrazol-1-yl)propionamide
  • N-(3-chloro-4-methyl-phenyl)-3-(3,5-dimethyl-4-piperidin-1-ylsulfonyl-pyrazol-1-yl)propanamide
  • G402-0889
  • NCGC00130841-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0032 0.1677
Schistosoma mansoni ferritin light chain 0.001 0.0001 0.0003
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0006 0.0006
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0038 0.0095 0.0218
Echinococcus multilocularis beta adrenergic receptor kinase 0.0058 0.0163 0.0163
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0015 0.0017 0.004
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0101 0.2787
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.0048
Leishmania major hypothetical protein, conserved 0.0022 0.0041 0.04
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0038 0.0095 0.0476
Mycobacterium leprae PROBABLE GAMMA-GLUTAMYL PHOSPHATE REDUCTASE PROTEIN PROA (GPR) (GLUTAMATE-5-SEMIALDEHYDE DEHYDROGENASE) (GLUTAMYL-GAMMA-SEMIALDE 0.0017 0.0024 0.062
Brugia malayi conserved hypotetical protein 0.0018 0.0027 0.0137
Echinococcus multilocularis musashi 0.0112 0.0346 0.0346
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0013 0.001 0.001
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0253 0.0821 0.0821
Toxoplasma gondii PAN domain-containing protein 0.0014 0.0015 0.0141
Loa Loa (eye worm) TATA binding protein associated factor 0.0012 0.0008 0.004
Loa Loa (eye worm) aminopeptidase N 0.0012 0.0008 0.004
Echinococcus multilocularis FTZ F1 alpha 0.0038 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0099 0.0301 0.1513
Schistosoma mansoni nAChR subunit 0.0013 0.001 0.0022
Echinococcus granulosus glycine receptor subunit alpha 1 0.0013 0.001 0.001
Plasmodium vivax thrombospondin-related anonymous protein 0.0055 0.0153 0.8681
Treponema pallidum gamma-glutamyl phosphate reductase 0.0017 0.0024 0.0034
Loa Loa (eye worm) hypothetical protein 0.0038 0.0095 0.0476
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0017 0.0024 0.0641
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.002 0.0034 0.0034
Brugia malayi ecdysteroid receptor 0.0038 0.0095 0.0476
Echinococcus granulosus RUN 0.0019 0.0032 0.0032
Leishmania major aldehyde dehydrogenase, putative 0.0017 0.0024 0.0232
Echinococcus granulosus collagen alpha 1VII chain 0.0055 0.0153 0.0153
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0017 0.0024 0.0024
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0015 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.002 0.0034 0.0173
Schistosoma mansoni aldehyde dehydrogenase 0.0017 0.0024 0.0055
Brugia malayi regulator of G-protein signaling rgs-7 0.0058 0.0163 0.0818
Loa Loa (eye worm) hypothetical protein 0.0054 0.015 0.0754
Loa Loa (eye worm) hypothetical protein 0.0055 0.0153 0.0771
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0032 0.0032
Brugia malayi PXA domain containing protein 0.0058 0.0163 0.0818
Loa Loa (eye worm) hypothetical protein 0.0052 0.0143 0.0719
Loa Loa (eye worm) hypothetical protein 0.0099 0.0301 0.1513
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0073
Mycobacterium tuberculosis Probable aldehyde dehydrogenase NAD dependent AldA (aldehyde dehydrogenase [NAD+]) 0.0017 0.0024 0.0224
Brugia malayi hypothetical protein 0.0018 0.0027 0.0137
Loa Loa (eye worm) hypothetical protein 0.0055 0.0153 0.0771
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0012 0.0008 0.004
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0074 1
Toxoplasma gondii PAN/Apple domain-containing protein 0.0014 0.0015 0.0141
Mycobacterium ulcerans gamma-glutamyl phosphate reductase 0.0017 0.0024 0.0224
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0055 0.0153 0.0771
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0074 0.0447
Schistosoma mansoni regulator of G protein signaling 0.0058 0.0163 0.0374
Schistosoma mansoni hypothetical protein 0.0012 0.0006 0.0014
Schistosoma mansoni nuclear receptor nhr-48 0.0018 0.0027 0.0063
Loa Loa (eye worm) hypothetical protein 0.0058 0.0163 0.0818
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0012 0.0008 0.0073
Loa Loa (eye worm) RGS-3 protein 0.0058 0.0163 0.0818
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.0055 0.0153 0.0771
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 0.0017 0.0024 0.0224
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0012 0.0008 0.0427
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0229 0.0739 0.0739
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.0075 0.0747
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.009 0.0892
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.009 0.0133
Echinococcus granulosus dnaJ subfamily B 0.0402 0.1323 0.1323
Echinococcus multilocularis RUN 0.0019 0.0032 0.0032
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0013 0.001 0.0048
Loa Loa (eye worm) hypothetical protein 0.002 0.0034 0.0173
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0038 0.0095 0.0476
Brugia malayi hypothetical protein 0.0015 0.0017 0.0088
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.0048
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0017 0.0024 0.0646
Echinococcus multilocularis regulator of G protein signaling 7 0.0058 0.0163 0.0163
Schistosoma mansoni axis inhibition protein axin 0.0058 0.0163 0.0374
Schistosoma mansoni aldehyde dehydrogenase 0.0017 0.0024 0.0055
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.0074 0.0732
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0015 0.0017 0.0088
Schistosoma mansoni rotamase 0.0033 0.0078 0.0179
Schistosoma mansoni nAChR subunit 0.0013 0.001 0.0022
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0013 0.001 0.0022
Echinococcus granulosus aldehyde dehydrogenase family 3 member B1 0.0017 0.0024 0.0024
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0018 0.0027 0.0027
Schistosoma mansoni rab6-interacting 0.0019 0.0032 0.0074
Schistosoma mansoni hypothetical protein 0.0022 0.0041 0.0093
Treponema pallidum 76K protein 0.0055 0.0153 0.0225
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0058 0.0163 0.0818
Loa Loa (eye worm) hypothetical protein 0.011 0.0339 0.1705
Plasmodium falciparum cysteine repeat modular protein 1 0.0022 0.0041 0.2245
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0155 0.1546
Echinococcus granulosus tumor protein p63 0.0348 0.1138 0.1138
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.002 0.0034 0.0173
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0013 0.001 0.001
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0058 0.0163 0.0818
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.009 0.0892
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0112 0.0346 0.174
Brugia malayi PAN domain containing protein 0.0014 0.0015 0.0073
Loa Loa (eye worm) serotonin transporter b 0.0015 0.0017 0.0088
Leishmania major pyrroline-5-carboxylate synthetase-like protein 0.0017 0.0024 0.0232
Brugia malayi nuclear receptor NHR-88 0.0038 0.0095 0.0476
Brugia malayi von Willebrand Factor 0.0055 0.0153 0.0771
Onchocerca volvulus 0.0055 0.0153 0.0904
Onchocerca volvulus 0.0055 0.0153 0.0904
Brugia malayi von Willebrand factor type A domain containing protein 0.0055 0.0153 0.0771
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.0163 0.0374
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0362 0.2234
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0033 0.0164
Brugia malayi hypothetical protein 0.002 0.0034 0.0173
Brugia malayi hypothetical protein 0.0055 0.0153 0.0771
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0033 0.0193
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0033 0.0322
Trypanosoma brucei Aminopeptidase M1, putative 0.0012 0.0008 0.0203
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0012 0.0008 0.0208
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0008 0.0008
Toxoplasma gondii hypothetical protein 0.0014 0.0015 0.0141
Brugia malayi PAN domain containing protein 0.0014 0.0015 0.0073
Mycobacterium ulcerans NAD-dependent aldehyde dehydrogenase AldA 0.0017 0.0024 0.0224
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0074 0.0447
Loa Loa (eye worm) PAN domain-containing protein 0.0014 0.0015 0.0073
Echinococcus multilocularis ferritin 0.001 0.0001 0.0001
Brugia malayi Peptidase family M1 containing protein 0.0012 0.0008 0.004
Schistosoma mansoni axis inhibition protein axin 0.0058 0.0163 0.0374
Brugia malayi nuclear hormone receptor family member nhr-6 0.0018 0.0027 0.0137
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.0048
Brugia malayi Nuclear hormone receptor E75 0.0018 0.0027 0.0137
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0013 0.001 0.001
Echinococcus granulosus 6 phosphofructokinase 0.0117 0.0362 0.0362
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.0163 0.0374
Onchocerca volvulus 0.0015 0.0017 0.0059
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0033 0.0033
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0017 0.0024 0.0646
Plasmodium vivax amine transporter, putative 0.0015 0.0017 0.0967
Plasmodium vivax hypothetical protein, conserved 0.0015 0.0017 0.0967
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0015 0.0017 0.017
Echinococcus granulosus regulator of G protein signaling 3 0.0058 0.0163 0.0163
Brugia malayi nuclear receptor NHR-67 0.0018 0.0027 0.0137
Loa Loa (eye worm) hypothetical protein 0.0026 0.0054 0.0273
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0058 0.0163 0.0374
Mycobacterium ulcerans bifunctional acetaldehyde-CoA/alcohol dehydrogenase 0.0017 0.0024 0.0224
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0033 0.0164
Brugia malayi hypothetical protein 0.0012 0.0008 0.004
Loa Loa (eye worm) hypothetical protein 0.0038 0.0095 0.0476
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0013 0.001 0.0048
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0099 0.0301 0.0301
Loa Loa (eye worm) hypothetical protein 0.0015 0.0017 0.0088
Toxoplasma gondii aminopeptidase N protein 0.0012 0.0008 0.0075
Leishmania major delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0017 0.0024 0.0232
Plasmodium falciparum amino acid transporter, putative 0.0015 0.0017 0.0654
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0176 0.0406
Plasmodium vivax hypothetical protein, conserved 0.0055 0.0153 0.8681
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0015 0.0017 0.0088
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0453 0.2279
Brugia malayi hypothetical protein 0.012 0.0371 0.1865
Toxoplasma gondii microneme protein MIC17B 0.0014 0.0015 0.0141
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.009 0.0552
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0137
Loa Loa (eye worm) norepinephrine transporter 0.0015 0.0017 0.0088
Leishmania major aldehyde dehydrogenase, putative 0.0017 0.0024 0.0232
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0017 0.0024 0.0646
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0058 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0038 0.0095 0.0476
Echinococcus multilocularis ecdysone induced protein 78C 0.0038 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0137
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0015 0.0017 0.0088
Brugia malayi Steroid receptor seven-up type 2 0.0038 0.0095 0.0476
Echinococcus granulosus expressed protein 0.113 0.3776 0.3776
Toxoplasma gondii hypothetical protein 0.0014 0.0015 0.0141
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0075 0.2065
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0137
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0013 0.001 0.0048
Loa Loa (eye worm) hypothetical protein 0.0112 0.0346 0.174
Brugia malayi von Willebrand factor type A domain containing protein 0.0055 0.0153 0.0771
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0137
Treponema pallidum hypothetical protein 0.0055 0.0153 0.0225
Toxoplasma gondii microneme protein MIC2 0.0055 0.0153 0.1529
Loa Loa (eye worm) solute carrier family 6 member 4 0.0015 0.0017 0.0088
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0013 0.001 0.001
Schistosoma mansoni sodium/chloride dependent transporter 0.0015 0.0017 0.004
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase [NADP+] dependent, GabD1 0.0017 0.0024 0.0224
Schistosoma mansoni polycystin 1-related 0.0019 0.0032 0.0074
Loa Loa (eye worm) hypothetical protein 0.0038 0.0095 0.0476
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.0048
Leishmania major ATP-dependent phosphofructokinase 0.0117 0.0362 0.3615
Brugia malayi Nuclear hormone receptor-like 1 0.0038 0.0095 0.0476
Brugia malayi nuclear receptor RXR 0.002 0.0034 0.0173
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0074 0.4159
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0034 0.0173
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0013 0.001 0.001
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0033 0.17
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0078 0.0391
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.004
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0034 0.0173
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0015 0.0017 0.017
Entamoeba histolytica hypothetical protein, conserved 0.0055 0.0153 0.4228
Loa Loa (eye worm) intermediate filament protein 0.0112 0.0346 0.174
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0117 0.0362 1
Onchocerca volvulus 0.0028 0.0062 0.0337
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0038 0.0095 0.0218
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0013 0.001 0.001
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0655 0.2173 0.5003
Toxoplasma gondii PAN domain-containing protein 0.0014 0.0015 0.0141
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0163 0.0998
Brugia malayi hypothetical protein 0.0019 0.0032 0.0162
Onchocerca volvulus 0.0014 0.0015 0.0041
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0017 0.0024 0.0646
Schistosoma mansoni loxhd1 0.0019 0.0032 0.0074
Toxoplasma gondii aldehyde dehydrogenase 0.0307 0.1 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0153 0.0771
Echinococcus granulosus voltage dependent calcium channel subunit 0.1354 0.453 0.453
Onchocerca volvulus 0.0014 0.0015 0.0041
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.004 0.0101 0.051
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0017 0.0024 0.0646
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.0048
Loa Loa (eye worm) phosphofructokinase 0.0117 0.0362 0.1821
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0229 0.0739 0.1701
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0101 0.0619
Schistosoma mansoni thyroid hormone receptor 0.0291 0.0949 0.2184
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0101 0.2791
Loa Loa (eye worm) steroid hormone receptor 0.0038 0.0095 0.0476
Loa Loa (eye worm) hypothetical protein 0.0055 0.0153 0.0771
Onchocerca volvulus 0.0013 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0038 0.0095 0.0476
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0038 0.0095 0.0476
Loa Loa (eye worm) hypothetical protein 0.0055 0.0153 0.0771
Brugia malayi Intermediate filament tail domain containing protein 0.0112 0.0346 0.174
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0074 0.0447
Mycobacterium ulcerans piperideine-6-carboxilic acid dehydrogenase Pcd 0.0017 0.0024 0.0224
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0012 0.0008 0.0008
Loa Loa (eye worm) nuclear receptor NHR-67 0.0018 0.0027 0.0137
Echinococcus granulosus intermediate filament protein 0.0112 0.0346 0.0346
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.001 0.0001 0.0005
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0054 0.0272
Brugia malayi Nuclear hormone receptor E75 0.0018 0.0027 0.0137
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.0048
Loa Loa (eye worm) hypothetical protein 0.002 0.0034 0.0173
Schistosoma mansoni rab6-interacting 0.0019 0.0032 0.0074
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0027 0.0027
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0033 0.0887
Toxoplasma gondii hypothetical protein 0.0015 0.0017 0.017
Mycobacterium ulcerans gamma-aminobutyraldehyde dehydrogenase 0.0017 0.0024 0.0224
Schistosoma mansoni nuclear receptor 0.0018 0.0027 0.0063
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0038 0.0095 0.0095
Onchocerca volvulus Putative nachr subunit 0.0013 0.001 0.001
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0013 0.001 0.001
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0038 0.0095 0.0476
Brugia malayi hypothetical protein 0.0255 0.0826 0.4158
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0038 0.0095 0.0095
Trichomonas vaginalis rotamase, putative 0.0033 0.0078 0.0473
Entamoeba histolytica aldehyde dehydrogenase 1, putative 0.0017 0.0024 0.0646
Onchocerca volvulus 0.0052 0.0142 0.0835
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0038 0.0095 0.0476
Echinococcus granulosus regulator of G protein signaling 3 0.0058 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0073
Loa Loa (eye worm) PXA domain-containing protein 0.0058 0.0163 0.0818
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0013 0.001 0.0048
Brugia malayi Regulator of G protein signaling domain containing protein 0.0058 0.0163 0.0818
Mycobacterium ulcerans aldehyde dehydrogenase 0.0017 0.0024 0.0224
Echinococcus granulosus nAChR subunit 0.0013 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.002 0.0034 0.0173
Loa Loa (eye worm) hypothetical protein 0.0055 0.0153 0.0771
Onchocerca volvulus 0.0062 0.0176 0.1049
Schistosoma mansoni ferritin 0.001 0.0001 0.0003
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0017 0.0024 0.0646
Loa Loa (eye worm) hypothetical protein 0.0055 0.0153 0.0771
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0013 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0137
Echinococcus multilocularis nuclear receptor nhr 48 0.0018 0.0027 0.0027
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0017 0.0024 0.0024
Schistosoma mansoni hypothetical protein 0.0402 0.1323 0.3047
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0015 0.0018 0.0042
Schistosoma mansoni lipoxygenase 0.0054 0.015 0.0345
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0012 0.0008 0.0008
Toxoplasma gondii PAN domain-containing protein 0.0014 0.0015 0.0141
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0101 0.0619
Echinococcus multilocularis nAChR subunit 0.0013 0.001 0.001
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0017 0.0024 0.0646
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0058 0.0163 0.0818
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0012 0.0008 0.0203
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0033 0.0891
Entamoeba histolytica aminopeptidase, putative 0.0012 0.0008 0.0208
Schistosoma mansoni ferritin light chain 0.001 0.0001 0.0003
Echinococcus granulosus Nuclear hormone receptor HR96 0.0018 0.0027 0.0027
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0032 0.0032
Brugia malayi hypothetical protein 0.0026 0.0054 0.0273
Echinococcus granulosus sodium and chloride dependent glycine 0.0015 0.0017 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0038 0.0095 0.0476
Loa Loa (eye worm) hypothetical protein 0.0055 0.0153 0.0771
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0038 0.0095 0.0476
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.009 0.2492
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.001 0.0001 0.0092
Echinococcus multilocularis glycine receptor subunit beta 0.0013 0.001 0.001
Mycobacterium tuberculosis Probable gamma-glutamyl phosphate reductase protein ProA (GPR) (glutamate-5-semialdehyde dehydrogenase) (glutamyl-gamma-semialde 0.0017 0.0024 0.0224
Mycobacterium ulcerans aldehyde dehydrogenase (NAD+) dependent 0.0017 0.0024 0.0224
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0015 0.0017 0.0088
Schistosoma mansoni serine-rich repeat protein 0.0699 0.2324 0.5349
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0038 0.0095 0.0476
Echinococcus granulosus beta-adrenergic receptor kinase 0.0058 0.0163 0.0163
Brugia malayi photoreceptor-specific nuclear receptor 0.0038 0.0095 0.0476
Toxoplasma gondii kringle domain-containing protein 0.0022 0.0041 0.0401
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0013 0.001 0.0048
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0027 0.0063
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0032 0.0074 0.0108
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.0048
Loa Loa (eye worm) TK/ROR protein kinase 0.0022 0.0041 0.0204
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0013 0.001 0.0048
Loa Loa (eye worm) ACC-1 protein 0.0013 0.001 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0163 0.0998
Mycobacterium ulcerans NAD-dependent aldehyde dehydrogenase AldA 0.0017 0.0024 0.0224
Echinococcus granulosus serotonin transporter 0.0015 0.0017 0.0017
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0 0.0001
Onchocerca volvulus 0.0051 0.0138 0.0812
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0012 0.0008 0.0073
Brugia malayi Aldehyde dehydrogenase protein 4 0.0017 0.0024 0.012
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0012 0.0008 0.0208
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0101 0.2791
Loa Loa (eye worm) hypothetical protein 0.0055 0.0153 0.0771
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0362 0.2234
Schistosoma mansoni aldehyde dehydrogenase 0.0017 0.0024 0.0055
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.009 0.09
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0074 0.4159
Trichomonas vaginalis succinate semialdehyde dehydrogenase, putative 0.0017 0.0024 0.0138
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0033 0.0164
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0013 0.001 0.0048
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0453 0.2279
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0163 0.0998
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0013 0.001 0.001
Echinococcus multilocularis ubiquitin specific protease 41 0.004 0.0101 0.0101
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.001 0.0001 0.0002
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0012 0.0008 0.0008
Entamoeba histolytica hypothetical protein 0.0058 0.0163 0.4485
Onchocerca volvulus 0.0018 0.0027 0.012
Brugia malayi follicle stimulating hormone receptor 0.0252 0.0816 0.4109
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0038 0.0095 0.0218
Loa Loa (eye worm) hypothetical protein 0.002 0.0034 0.0173
Brugia malayi Kringle domain containing protein 0.0022 0.0041 0.0204
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0137
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0163 0.0998
Brugia malayi Peptidase family M1 containing protein 0.0012 0.0008 0.004
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.0048
Brugia malayi Protein kinase domain containing protein 0.0022 0.0041 0.0204
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.0362 1
Loa Loa (eye worm) PAN domain-containing protein 0.0014 0.0015 0.0073
Loa Loa (eye worm) PAN domain-containing protein 0.0014 0.0015 0.0073
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0307 0.1 1
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.004 0.0101 0.0233
Brugia malayi von Willebrand factor type A domain containing protein 0.0055 0.0153 0.0771
Brugia malayi Cation transporter family protein 0.0013 0.001 0.0048
Schistosoma mansoni sodium/chloride dependent transporter 0.0015 0.0017 0.004
Onchocerca volvulus 0.0014 0.0015 0.0041
Brugia malayi Doublecortin family protein 0.0019 0.0032 0.0162
Echinococcus multilocularis regulator of G protein signaling 3 0.0058 0.0163 0.0163
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0054 0.015 0.015
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0013 0.001 0.0048
Brugia malayi 6-phosphofructokinase 0.0117 0.0362 0.1821
Loa Loa (eye worm) hypothetical protein 0.001 0 0.0002
Onchocerca volvulus 0.0015 0.0017 0.0059
Schistosoma mansoni aldehyde dehydrogenase 0.0017 0.0024 0.0055
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0032 0.0074 0.6431
Loa Loa (eye worm) RecQ helicase 0.002 0.0033 0.0164
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0038 0.0095 0.0476
Entamoeba histolytica elongation factor-2 kinase, putative 0.0055 0.0153 0.4228
Echinococcus granulosus tissue type plasminogen activator 0.0022 0.0041 0.0041
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0054 0.1491
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0017 0.0024 0.0646
Entamoeba histolytica hypothetical protein 0.0055 0.0153 0.4228
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0008 0.0008
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0033 0.0033
Onchocerca volvulus 0.0055 0.0153 0.0904
Loa Loa (eye worm) PAN domain-containing protein 0.0014 0.0015 0.0073
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0058 0.0163 0.0374
Schistosoma mansoni hypothetical protein 0.0055 0.0153 0.0353
Schistosoma mansoni RAR-like nuclear receptor 0.0038 0.0095 0.0218
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0054 0.0539
Echinococcus granulosus cpg binding protein 0.003 0.0068 0.0068
Schistosoma mansoni survival motor neuron protein 0.0052 0.0142 0.0327
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0038 0.0095 0.0218
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0017 0.0024 0.0646
Treponema pallidum bacterioferrin (TpF1) 0.001 0.0001 0.0001
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0015 0.0017 0.004
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.0048
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.009 0.009
Schistosoma mansoni apoferritin-2 0.001 0.0001 0.0003
Schistosoma mansoni ferritin 0.001 0.0001 0.0003
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0013 0.001 0.001
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0013 0.001 0.0048
Onchocerca volvulus 0.0014 0.0015 0.0041
Schistosoma mansoni hypothetical protein 0.0019 0.0032 0.0074
Echinococcus granulosus geminin 0.0167 0.0529 0.0529
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0033 0.17
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0038 0.0095 0.0095
Brugia malayi tailless protein 0.0018 0.0027 0.0137
Entamoeba histolytica hypothetical protein, conserved 0.0055 0.0153 0.4228
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0012 0.0008 0.0018
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0038 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.0048
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0038 0.0095 0.0095
Onchocerca volvulus 0.0055 0.0153 0.0904
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0033 0.0193
Onchocerca volvulus 0.0112 0.0346 0.2102
Onchocerca volvulus Protein ultraspiracle homolog 0.0038 0.0095 0.054
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0078 0.0473
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0074 1
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0015 0.0017 0.0088
Loa Loa (eye worm) hypothetical protein 0.0055 0.0153 0.0771
Loa Loa (eye worm) hypothetical protein 0.0062 0.0176 0.0888
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0018 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0255 0.0826 0.4158
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0099 0.0301 0.0692
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0013 0.001 0.0022
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0058 0.0163 0.0374
Schistosoma mansoni hypothetical protein 0.0167 0.0529 0.1217
Echinococcus multilocularis thyroid hormone receptor alpha 0.0291 0.0949 0.0949
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0075 0.2065
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0058 0.0163 0.0998
Brugia malayi PAN domain containing protein 0.0014 0.0015 0.0073
Mycobacterium leprae PROBABLE ALDEHYDE DEHYDROGENASE (NAD+) DEPENDENT 0.0017 0.0024 0.062
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.004 0.0101 0.0101
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0033 0.1144
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0015 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0015 0.0017 0.0088
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0117 0.0362 1
Toxoplasma gondii aminopeptidase n, putative 0.0012 0.0008 0.0075
Mycobacterium ulcerans aldehyde dehydrogenase 0.0307 0.1 1
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0015 0.0017 0.004
Onchocerca volvulus 0.0013 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.0048
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0038 0.0095 0.0218
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0022 0.0041 0.2279
Loa Loa (eye worm) hypothetical protein 0.0058 0.0163 0.0818
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0018 0.0027 0.012
Brugia malayi A-kinase anchor protein 10, precursor 0.0058 0.0163 0.0818
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.012
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0017 0.0024 0.0641
Brugia malayi PAN domain containing protein 0.0014 0.0015 0.0073
Schistosoma mansoni nuclear hormone receptor 0.0038 0.0095 0.0218
Brugia malayi Cytochrome P450 family protein 0.0026 0.0054 0.0272
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.0048
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0015 0.0017 0.0017
Schistosoma mansoni aldehyde dehydrogenase 0.0017 0.0024 0.0055
Schistosoma mansoni regulator of G protein signaling 0.0058 0.0163 0.0374
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.0074 0.2025
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0013 0.001 0.001
Trypanosoma cruzi aminopeptidase, putative 0.0012 0.0008 0.0208
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.0055 0.0153 0.8681
Schistosoma mansoni intermediate filament proteins 0.0112 0.0346 0.0796
Brugia malayi hypothetical protein 0.0105 0.0322 0.162
Schistosoma mansoni cpg binding protein 0.0028 0.0062 0.0143
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0012 0.0008 0.0208
Brugia malayi hypothetical protein 0.0017 0.0023 0.0117
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0015 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.004
Schistosoma mansoni hypothetical protein 0.0037 0.0092 0.0211
Loa Loa (eye worm) hypothetical protein 0.0015 0.0017 0.0088
Toxoplasma gondii aldehyde dehydrogenase (NAD) family protein 0.0017 0.0024 0.0234
Toxoplasma gondii subtilisin SUB12 0.0014 0.0015 0.0141
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0074 0.0447
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0038 0.0095 0.0095
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0078 0.0391
Toxoplasma gondii methylmalonate-semialdehyde dehydrogenase [acylating], putative 0.0017 0.0024 0.0234
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.0074 0.0732
Schistosoma mansoni nAChR subunit 0.0013 0.001 0.0022
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.0048
Brugia malayi Succinate semialdehyde dehydrogenase, mitochondrial precursor 0.0017 0.0024 0.012
Loa Loa (eye worm) hypothetical protein 0.001 0 0.0002
Brugia malayi Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor 0.0017 0.0024 0.012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0038 0.0095 0.0476
Onchocerca volvulus 0.0055 0.0153 0.0904
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.0055 0.0153 0.0771
Echinococcus multilocularis cpg binding protein 0.003 0.0068 0.0068
Echinococcus multilocularis expressed protein 0.001 0.0001 0.0001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0038 0.0095 0.0476
Schistosoma mansoni apoferritin-2 0.001 0.0001 0.0003
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.0074 0.0732
Echinococcus granulosus histone lysine methyltransferase setb 0.0062 0.0176 0.0176
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.004 0.0101 0.0101
Echinococcus granulosus Nuclear hormone receptor HR96 0.0018 0.0027 0.0027
Echinococcus multilocularis regulator of G protein signaling 7 0.0058 0.0163 0.0163
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0038 0.0095 0.0476
Brugia malayi nuclear hormone receptor 0.0038 0.0095 0.0476
Mycobacterium tuberculosis Probable methylmalonate-semialdehyde dehydrogenase MmsA (methylmalonic acid semialdehyde dehydrogenase) (MMSDH) 0.0017 0.0024 0.0224
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0017 0.0024 0.0646
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.0055 0.0153 0.8681
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0058 0.0163 0.0163
Onchocerca volvulus 0.0015 0.0017 0.0059
Echinococcus granulosus regulator of G protein signaling 7 0.0058 0.0163 0.0163
Brugia malayi PAN domain containing protein 0.0014 0.0015 0.0073
Schistosoma mansoni DNA helicase recq1 0.002 0.0033 0.0075
Onchocerca volvulus 0.0015 0.0017 0.0059
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0008 0.0008
Mycobacterium ulcerans aldehyde dehydrogenase 0.0307 0.1 1
Brugia malayi CXXC zinc finger family protein 0.0028 0.0062 0.0313
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0032 0.0032
Schistosoma mansoni retinoic acid receptor RXR 0.0038 0.0095 0.0218
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0013 0.001 0.001
Mycobacterium ulcerans aldehyde dehydrogenase 0.0307 0.1 1
Brugia malayi aldehyde dehydrogenase 0.0017 0.0024 0.012
Mycobacterium leprae PROBABLE SUCCINATE-SEMIALDEHYDE DEHYDROGENASE [NADP+] DEPENDENT (SSDH) GABD 0.0017 0.0024 0.062
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0018 0.0027 0.0063
Loa Loa (eye worm) hypothetical protein 0.0015 0.0017 0.0088
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.004 0.0101 0.1007
Onchocerca volvulus 0.0013 0.001 0.001
Brugia malayi Immunoglobulin I-set domain containing protein 0.0055 0.0153 0.0771
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0013 0.001 0.0022
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0798 0.2656 0.2656
Schistosoma mansoni hypothetical protein 0.0055 0.0153 0.0353
Brugia malayi hypothetical protein 0.0019 0.0032 0.0162
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0004 0.002
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0055 0.0153 0.0941
Schistosoma mansoni ferritin 0.001 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.004 0.0101 0.051
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0073
Loa Loa (eye worm) DR-78 0.0018 0.0027 0.0137
Loa Loa (eye worm) CUTiclin family member 0.0055 0.0153 0.0771
Brugia malayi hypothetical protein 0.0058 0.0163 0.0818
Treponema pallidum sodium- and chloride- dependent transporter 0.0015 0.0017 0.0025
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.0048
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0033 0.0164
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0012 0.0008 0.0427
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0038 0.0095 0.0095
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0004 0.0004
Echinococcus multilocularis glycine receptor subunit beta 0.0013 0.001 0.001
Entamoeba histolytica hypothetical protein 0.0037 0.0092 0.2524
Toxoplasma gondii PAN domain-containing protein 0.0014 0.0015 0.0141
Brugia malayi von Willebrand factor type A domain containing protein 0.0055 0.0153 0.0771
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.009 0.2492
Brugia malayi hypothetical protein 0.0058 0.0163 0.0818
Entamoeba histolytica recQ family helicase, putative 0.002 0.0033 0.0891
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0307 0.1 0.1
Mycobacterium ulcerans pyrroline-5-carboxylate dehydrogenase, RocA 0.0017 0.0024 0.0224
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0062 0.0176 0.0176
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.004 0.0101 0.0101
Schistosoma mansoni nAChR subunit 0.0013 0.001 0.0022
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0012 0.0008 0.004
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0054 0.015 0.015
Echinococcus multilocularis aldehyde dehydrogenase family 3 member B1 0.0017 0.0024 0.0024
Onchocerca volvulus 0.0018 0.0027 0.012
Brugia malayi Cation transporter family protein 0.0013 0.001 0.0048
Brugia malayi hypothetical protein 0.0037 0.0092 0.0461
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0229 0.0739 0.3719
Toxoplasma gondii aminopeptidase N, putative 0.0012 0.0008 0.0075
Echinococcus multilocularis axis inhibition protein axin 0.0058 0.0163 0.0163
Echinococcus granulosus succinate semialdehyde dehydrogenase 0.0017 0.0024 0.0024
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0074 0.0447
Onchocerca volvulus 0.0013 0.001 0.001
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0033 0.0033
Schistosoma mansoni 6-phosphofructokinase 0.0117 0.0362 0.0833
Echinococcus granulosus thyroid hormone receptor alpha 0.0018 0.0027 0.0027
Echinococcus multilocularis voltage dependent calcium channel subunit 0.2977 1 1
Onchocerca volvulus 0.0014 0.0015 0.0041
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0075 0.2065
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0038 0.0095 0.0476
Entamoeba histolytica hypothetical protein 0.0058 0.0163 0.4485
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0092 0.0092
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0062 0.0176 0.0176
Echinococcus granulosus survival motor neuron protein 1 0.0255 0.0826 0.0826
Loa Loa (eye worm) hypothetical protein 0.0038 0.0095 0.0476
Echinococcus multilocularis regulator of G protein signaling 3 0.0058 0.0163 0.0163
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0032 0.0032
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0013 0.001 0.0022
Echinococcus multilocularis survival motor neuron protein 1 0.0255 0.0826 0.0826
Onchocerca volvulus 0.0055 0.0153 0.0904
Brugia malayi von Willebrand factor type A domain containing protein 0.0055 0.0153 0.0771
Onchocerca volvulus 0.0038 0.0095 0.054
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0015 0.0017 0.004
Brugia malayi orphan nuclear receptor NR2E1 0.0018 0.0027 0.0137
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0167 0.0167
Echinococcus granulosus Regulator of G protein signaling 20 0.0058 0.0163 0.0163
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0013 0.001 0.0048
Mycobacterium tuberculosis Possible succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD2 0.0017 0.0024 0.0224
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.0362 1
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0013 0.001 0.0048
Schistosoma mansoni hypothetical protein 0.0699 0.2324 0.5349
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.043 0.1415 0.7124
Brugia malayi intermediate filament protein 0.0112 0.0346 0.174
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0017 0.0024 0.0646
Echinococcus granulosus lamin dm0 0.0112 0.0346 0.0346
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.004
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0033 0.0033
Onchocerca volvulus 0.0055 0.0153 0.0904
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0013 0.001 0.0022
Echinococcus multilocularis collagen alpha 1(VII) chain 0.0055 0.0153 0.0153
Toxoplasma gondii hypothetical protein 0.0015 0.0017 0.017
Mycobacterium ulcerans 6-phosphofructokinase 0.0117 0.0362 0.3609
Schistosoma mansoni nAChR subunit 0.0013 0.001 0.0022
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0038 0.0095 0.0218
Echinococcus multilocularis Regulator of G protein signaling 20 0.0058 0.0163 0.0163
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0362 0.2234
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0013 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0253 0.0821 0.189
Loa Loa (eye worm) nuclear hormone receptor 0.0018 0.0027 0.0137
Loa Loa (eye worm) hypothetical protein 0.0058 0.0163 0.0818
Trypanosoma brucei Aminopeptidase M1, putative 0.0012 0.0008 0.0203
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0062 0.0176 0.1761
Echinococcus granulosus bloom syndrome protein 0.002 0.0033 0.0033
Trypanosoma cruzi Aminopeptidase M1, putative 0.0012 0.0008 0.0208
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.009 0.861
Brugia malayi Zona pellucida-like domain containing protein 0.0055 0.0153 0.0771
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0013 0.001 0.0048
Schistosoma mansoni regulator of G protein signaling 0.0058 0.0163 0.0374
Toxoplasma gondii microneme protein, putative 0.0014 0.0015 0.0141
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0038 0.0095 0.0095
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0017 0.0024 0.0646
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0038 0.0095 0.0095
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.009 0.0552
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0038 0.0095 0.0476
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.006 0.017 0.0855
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0012 0.0008 0.0073
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0013 0.001 0.0048
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0099 0.0301 0.0692
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0137
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0073
Onchocerca volvulus 0.0019 0.0032 0.0152
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.002 0.0034 0.0079
Trichomonas vaginalis set domain proteins, putative 0.0489 0.1615 1
Brugia malayi PAN domain containing protein 0.0014 0.0015 0.0073
Loa Loa (eye worm) hypothetical protein 0.0052 0.0143 0.0719
Echinococcus granulosus leukotriene A 4 hydrolase 0.0229 0.0739 0.0739
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0004 0.0018
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0176 0.0406
Echinococcus multilocularis dnaJ subfamily B 0.0402 0.1323 0.1323
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.0048
Loa Loa (eye worm) hypothetical protein 0.002 0.0033 0.0164
Loa Loa (eye worm) hypothetical protein 0.0051 0.0138 0.0696
Onchocerca volvulus Bile acid receptor homolog 0.0038 0.0095 0.054
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0137
Echinococcus multilocularis sodium and chloride dependent glycine 0.0015 0.0017 0.0017
Schistosoma mansoni cpg binding protein 0.003 0.0068 0.0156
Onchocerca volvulus 0.0489 0.1615 1
Plasmodium falciparum von Willebrand factor A domain-related protein 0.0055 0.0153 1
Echinococcus granulosus regulator of G protein signaling 7 0.0058 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0055 0.0153 0.0771
Entamoeba histolytica hypothetical protein 0.0037 0.0092 0.2524
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0013 0.001 0.0022
Brugia malayi excitatory GABA receptor EXP-1A 0.0013 0.001 0.0048
Schistosoma mansoni hypothetical protein 0.0017 0.0024 0.0055
Toxoplasma gondii NADP-dependent succinate-semialdehyde dehydrogenase 0.0017 0.0024 0.0234
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0074 0.4521
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0034 0.0079
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0062 0.0313
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0117 0.0362 0.0533
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0017 0.0024 0.0641
Treponema pallidum methyl-accepting chemotaxis protein (mcp2-1) 0.2024 0.6787 1
Entamoeba histolytica hypothetical protein 0.0037 0.0092 0.2524
Schistosoma mansoni hypothetical protein 0.0167 0.0529 0.1217
Echinococcus granulosus Fatty aldehyde dehydrogenase 0.0017 0.0024 0.0024
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.015 0.015
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0008 0.0008
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0101 0.0619
Mycobacterium tuberculosis Probable aldehyde dehydrogenase AldC 0.0017 0.0024 0.0224
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0018 0.0027 0.0063
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0013 0.001 0.0048
Echinococcus granulosus aminopeptidase N 0.0012 0.0008 0.0008
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0008 0.0008
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0017 0.0024 0.0224
Onchocerca volvulus 0.0013 0.001 0.001
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.0074 0.0447
Loa Loa (eye worm) 6-phosphofructokinase 0.0117 0.0362 0.1821
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0012 0.0008 0.0018
Echinococcus multilocularis betaine aldehyde dehydrogenase 0.0017 0.0024 0.0024
Echinococcus granulosus expressed protein 0.0033 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0015 0.0017 0.0088
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.009 0.009
Echinococcus multilocularis bloom syndrome protein 0.002 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0055 0.0153 0.0771
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase 0.0017 0.0024 0.0224
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0033 0.0193
Echinococcus granulosus ecdysone induced protein 78C 0.0038 0.0095 0.0095
Mycobacterium ulcerans aminopeptidase N PepN 0.0012 0.0008 0.0065
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0252 0.0816 0.4109
Brugia malayi hypothetical protein 0.0018 0.0027 0.0137
Schistosoma mansoni aldehyde dehydrogenase 0.0307 0.1 0.2302
Schistosoma mansoni cpg binding protein 0.003 0.0068 0.0156
Echinococcus multilocularis lamin 0.0112 0.0346 0.0346
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0062 0.0176 0.0406
Echinococcus granulosus lamin 0.0112 0.0346 0.0346
Onchocerca volvulus 0.0013 0.001 0.001
Echinococcus granulosus axis inhibition protein axin 0.0058 0.0163 0.0163
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0012 0.0008 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0038 0.0095 0.0476
Onchocerca volvulus 0.0014 0.0015 0.0041
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.009 0.5118
Loa Loa (eye worm) delta-1-pyrroline-5-carboxylate dehydrogenase 0.0017 0.0024 0.012
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.009 0.0455
Schistosoma mansoni sodium/chloride dependent transporter 0.0015 0.0017 0.004
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.004 0.0101 1
Echinococcus granulosus ubiquitin specific protease 41 0.004 0.0101 0.0101
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0092 0.0211
Echinococcus multilocularis aminopeptidase N 0.0012 0.0008 0.0008
Echinococcus multilocularis expressed protein 0.0033 0.0078 0.0078
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0013 0.001 0.0048
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0006 0.0006
Mycobacterium tuberculosis Probable pyrroline-5-carboxylate dehydrogenase RocA 0.0017 0.0024 0.0224
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.0055 0.0153 0.8681
Loa Loa (eye worm) aldehyde dehydrogenase 4 0.0017 0.0024 0.012
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0013 0.001 0.0048
Echinococcus granulosus ferritin 0.001 0.0001 0.0001
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0013 0.001 0.001
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0038 0.0095 0.0095
Loa Loa (eye worm) ACC-1 protein 0.0013 0.001 0.0048
Brugia malayi nuclear hormone receptor family member odr-7 0.0018 0.0027 0.0137
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0018 0.0027 0.012
Loa Loa (eye worm) hypothetical protein 0.0055 0.0153 0.0771
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0018 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0073
Toxoplasma gondii microneme protein MIC17C 0.0014 0.0015 0.0141
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0018 0.0027 0.0137
Loa Loa (eye worm) peptidase family M1 containing protein 0.0012 0.0008 0.004
Brugia malayi nuclear receptor RXR 0.0018 0.0027 0.0137
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0137
Brugia malayi nuclear hormone receptor 0.0018 0.0027 0.0137
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0012 0.0008 0.0008
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0015 0.0017 0.004
Echinococcus granulosus glycine receptor subunit beta 0.0013 0.001 0.001
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.001 0.0001 0.0005
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0012 0.0008 0.0008
Mycobacterium tuberculosis Probable aldehyde dehydrogenase (NAD+) dependent 0.0017 0.0024 0.0224
Echinococcus granulosus FTZ F1 alpha 0.0038 0.0095 0.0095
Schistosoma mansoni zinc finger protein 0.0018 0.0027 0.0063
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0054 0.3191
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0038 0.0095 0.0476
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0017 0.0024 0.0646
Toxoplasma gondii exonuclease III APE 0.0037 0.009 0.0901
Schistosoma mansoni aminopeptidase A (M01 family) 0.0012 0.0008 0.0018
Loa Loa (eye worm) hypothetical protein 0.0058 0.0163 0.0818
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0307 0.1 0.1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0017 0.0088
Mycobacterium ulcerans methylmalonate semialdehyde dehydrogenase, MmsA 0.0017 0.0024 0.0224
Plasmodium vivax SET domain protein, putative 0.0062 0.0176 1
Echinococcus multilocularis tumor protein p63 0.0348 0.1138 0.1138
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.004 0.0101 0.0233
Echinococcus granulosus expressed protein 0.001 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0022 0.0041 0.0204
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0117 0.0362 0.3609
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0099 0.0301 0.0692
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0038 0.0095 0.0095
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0362 0.2234
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.0162
Schistosoma mansoni ap endonuclease 0.0037 0.009 0.0208
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.009 0.0455
Trypanosoma brucei delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0017 0.0024 0.0641
Echinococcus multilocularis Fatty aldehyde dehydrogenase 0.0017 0.0024 0.0024
Toxoplasma gondii microneme protein MIC17A 0.0014 0.0015 0.0141
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0054 0.1491
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0038 0.0095 0.0476
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0177 0.0406
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0092 0.0092
Loa Loa (eye worm) 6-phosphofructokinase 0.0117 0.0362 0.1821
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0015 0.0017 0.004
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.0075 0.2061
Echinococcus granulosus glycine receptor subunit alpha 1 0.0013 0.001 0.001
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0012 0.0008 0.0208
Toxoplasma gondii microneme protein MIC4 0.0014 0.0015 0.0141
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.0162
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.012
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0054 0.3061
Schistosoma mansoni thyroid hormone receptor 0.0291 0.0949 0.2184
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0033 0.0321
Echinococcus multilocularis voltage dependent calcium channel subunit 0.1354 0.453 0.453
Brugia malayi von Willebrand factor type A domain containing protein 0.0055 0.0153 0.0771
Echinococcus granulosus glycine receptor subunit alpha 1 0.0013 0.001 0.001
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0041 0.111
Echinococcus multilocularis expressed protein 0.113 0.3776 0.3776
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0027 0.0027
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0013 0.001 0.0048
Brugia malayi regulator of G-protein signaling egl-10 0.0058 0.0163 0.0818
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0015 0.0017 0.017
Brugia malayi von Willebrand factor type A domain containing protein 0.0055 0.0153 0.0771
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.009 0.2492
Brugia malayi PXA domain containing protein 0.0058 0.0163 0.0818
Echinococcus multilocularis lamin dm0 0.0112 0.0346 0.0346
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0074 0.0447
Brugia malayi hypothetical protein 0.002 0.0034 0.0173
Schistosoma mansoni nAChR subunit 0.0013 0.001 0.0022
Entamoeba histolytica hypothetical protein 0.0058 0.0163 0.4485
Leishmania major aldehyde dehydrogenase, putative 0.0017 0.0024 0.0232
Loa Loa (eye worm) hypothetical protein 0.0055 0.0153 0.0771
Schistosoma mansoni sodium-dependent amino acid transporter 0.0015 0.0017 0.004
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0013 0.001 0.0048
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0033 0.0322
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.0055 0.0153 0.1529
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0038 0.0095 0.0476
Echinococcus granulosus nuclear receptor nhr 48 0.0018 0.0027 0.0027
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0054 0.3191
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.002 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0015 0.0017 0.0088
Brugia malayi PAN domain containing protein 0.0014 0.0015 0.0073
Echinococcus granulosus betaine aldehyde dehydrogenase 0.0017 0.0024 0.0024
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.009 0.5684
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0073
Echinococcus multilocularis geminin 0.0167 0.0529 0.0529
Loa Loa (eye worm) PAN domain-containing protein 0.0014 0.0015 0.0073
Brugia malayi PAN domain containing protein 0.0014 0.0015 0.0073
Schistosoma mansoni ferritin 0.001 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0137
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0307 0.1 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0142 0.0715
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.0048
Schistosoma mansoni lipoxygenase 0.0019 0.0032 0.0074
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.0075 0.0745
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0163 0.0998
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0017 0.0024 0.0646
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase 0.0017 0.0024 0.0224
Brugia malayi nuclear receptor NHR-88 0.0018 0.0027 0.0137
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0013 0.001 0.0048
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.004 0.0101 0.2791
Loa Loa (eye worm) aldehyde dehydrogenase 0.0017 0.0024 0.012
Loa Loa (eye worm) hypothetical protein 0.0038 0.0095 0.0476
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0012 0.0008 0.0073
Schistosoma mansoni aldehyde dehydrogenase 0.0307 0.1 0.2302
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0013 0.001 0.0048
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0117 0.0362 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0015 0.0017 0.0088
Plasmodium falciparum transporter, putative 0.0015 0.0017 0.0654
Brugia malayi Pre-SET motif family protein 0.043 0.1415 0.7124
Mycobacterium ulcerans aminopeptidase N PepN 0.0012 0.0008 0.0065
Brugia malayi ecdysone receptor 0.0018 0.0027 0.0137
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0032 0.0162
Onchocerca volvulus 0.0014 0.0015 0.0041
Loa Loa (eye worm) CUTiclin-Like family member 0.0055 0.0153 0.0771
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0032 0.0032
Toxoplasma gondii PAN domain-containing protein 0.0014 0.0015 0.0141
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0013 0.001 0.001
Toxoplasma gondii gamma-glutamyl phosphate reductase, putative 0.0017 0.0024 0.0234
Loa Loa (eye worm) hypothetical protein 0.0014 0.0015 0.0073
Schistosoma mansoni regulator of G protein signaling 0.0058 0.0163 0.0374
Brugia malayi phosphofructokinase 0.0117 0.0362 0.1821
Onchocerca volvulus 0.0014 0.0015 0.0041
Onchocerca volvulus Aldehyde dehydrogenase homolog 0.0017 0.0024 0.0099
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0099 0.0301 0.0301
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase [NADP+] dependent, PutA_2 0.0017 0.0024 0.0224
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0138 0.0319
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0137
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0013 0.001 0.001
Echinococcus multilocularis axis inhibition protein axin 0.0058 0.0163 0.0163
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0017 0.0024 0.0641
Echinococcus granulosus sodium and chloride dependent glycine 0.0015 0.0017 0.0017
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0038 0.0095 0.0095
Onchocerca volvulus 0.0014 0.0015 0.0041
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0038 0.0095 0.0476
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0176 0.0406
Echinococcus multilocularis serotonin transporter 0.0015 0.0017 0.0017
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0004 0.0004
Plasmodium falciparum thrombospondin-related anonymous protein 0.0055 0.0153 1
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.0055 0.0153 1
Schistosoma mansoni succinate semialdehyde dehydrogenase 0.0017 0.0024 0.0055
Loa Loa (eye worm) hypothetical protein 0.0038 0.0095 0.0476
Loa Loa (eye worm) hypothetical protein 0.0058 0.0163 0.0818
Loa Loa (eye worm) hypothetical protein 0.0058 0.0163 0.0818
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0137
Toxoplasma gondii PAN domain-containing protein 0.0014 0.0015 0.0141
Echinococcus granulosus axis inhibition protein axin 0.0058 0.0163 0.0163
Brugia malayi Peptidase family M1 containing protein 0.0012 0.0008 0.004
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0038 0.0095 0.054
Brugia malayi TATA binding protein associated factor 0.0012 0.0008 0.004
Brugia malayi Pre-SET motif family protein 0.0062 0.0176 0.0888
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.015 0.015
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0013 0.001 0.001
Echinococcus multilocularis regulator of G protein signaling 0.0058 0.0163 0.0163
Leishmania major hypothetical protein, conserved 0.0026 0.0054 0.0537
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0015 0.0017 0.0088
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0163 0.0998
Schistosoma mansoni lamin 0.0112 0.0346 0.0796
Onchocerca volvulus 0.0014 0.0015 0.0041
Brugia malayi PAN domain containing protein 0.0014 0.0015 0.0073
Onchocerca volvulus 0.0112 0.0346 0.2102
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0253 0.0821 0.0821
Brugia malayi von Willebrand factor type A domain containing protein 0.0055 0.0153 0.0771
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.009 0.2489
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0038 0.0095 0.0476
Brugia malayi cytoplasmic intermediate filament protein 0.006 0.017 0.0855
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0038 0.0095 0.0095
Brugia malayi 6-phosphofructokinase 0.0117 0.0362 0.1821
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0012 0.0008 0.004
Schistosoma mansoni lamin 0.0112 0.0346 0.0796
Loa Loa (eye worm) hypothetical protein 0.0312 0.1019 0.5128
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.0048
Loa Loa (eye worm) hypothetical protein 0.0599 0.1987 1
Brugia malayi steroid hormone receptor 0.0038 0.0095 0.0476
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.004 0.0101 0.0101
Echinococcus multilocularis 6 phosphofructokinase 0.0117 0.0362 0.0362
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0013 0.001 0.001
Schistosoma mansoni steroid hormone receptor ad4bp 0.0038 0.0095 0.0218
Loa Loa (eye worm) LGC-31 protein 0.0013 0.001 0.0048
Trichomonas vaginalis rotamase, putative 0.0032 0.0075 0.0456
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0015 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.0048
Entamoeba histolytica hypothetical protein 0.0037 0.0092 0.2524
Schistosoma mansoni ap endonuclease 0.0037 0.009 0.0208
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0032 0.0032
Schistosoma mansoni z-protein (S1r protein) 0.0058 0.0163 0.0374
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0018 0.0027 0.0027
Trypanosoma brucei aminopeptidase, putative 0.0012 0.0008 0.0203
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0013 0.001 0.0048
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.0163 0.0374
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0032 0.1811
Schistosoma mansoni coup transcription factor 0.0038 0.0095 0.0218
Schistosoma mansoni 6-phosphofructokinase 0.0117 0.0362 0.0833
Schistosoma mansoni regulator of G protein signaling 0.0058 0.0163 0.0374
Brugia malayi MH2 domain containing protein 0.0144 0.0453 0.2279
Brugia malayi Cation transporter family protein 0.0013 0.001 0.0048
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0012 0.0008 0.0208
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0018 0.0027 0.0137
Onchocerca volvulus 0.0022 0.0041 0.0203
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0137
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0058 0.0163 0.0818
Schistosoma mansoni nAChR subunit 0.0013 0.001 0.0022
Onchocerca volvulus 0.0019 0.0032 0.0152
Brugia malayi Cache domain containing protein 0.0599 0.1987 1
Trypanosoma cruzi aminopeptidase, putative 0.0012 0.0008 0.0208
Brugia malayi Regulator of G protein signaling domain containing protein 0.0058 0.0163 0.0818
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0017 0.0024 0.0646
Echinococcus granulosus glycine receptor subunit beta 0.0013 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.0048
Schistosoma mansoni nuclear receptor 0.0018 0.0027 0.0063
Echinococcus multilocularis sodium and chloride dependent glycine 0.0015 0.0017 0.0017
Onchocerca volvulus 0.0014 0.0015 0.0041
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0008 0.0008
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0018 0.0027 0.0027
Brugia malayi PAN domain containing protein 0.0014 0.0015 0.0073
Schistosoma mansoni hypothetical protein 0.0052 0.0142 0.0327
Brugia malayi hypothetical protein 0.0012 0.0008 0.004
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0054 0.1487
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.0362 1
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.1299 0.4344 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0017 0.0088
Schistosoma mansoni DNA helicase recq5 0.002 0.0033 0.0075
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0027 0.0063
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0013 0.001 0.0048
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0074 0.4521
Brugia malayi Zona pellucida-like domain containing protein 0.0055 0.0153 0.0771
Schistosoma mansoni delta 1-pyrroline-5-carboxylate synthetase 0.0017 0.0024 0.0055
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0014 0.0015 0.0141
Echinococcus multilocularis tissue type plasminogen activator 0.0022 0.0041 0.0041
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.009 1
Wolbachia endosymbiont of Brugia malayi bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase 0.0017 0.0024 0.2577

Activities

Activity type Activity value Assay description Source Reference
Potency (binding) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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