Detailed information for compound 1355568

Basic information

Technical information
  • TDR Targets ID: 1355568
  • Name: 1-(4-thieno[3,2-e]pyrimidin-4-yloxyphenyl)eth anone
  • MW: 270.306 | Formula: C14H10N2O2S
  • H donors: 0 H acceptors: 3 LogP: 3.1 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)c1ccc(cc1)Oc1ncnc2c1ccs2
  • InChi: 1S/C14H10N2O2S/c1-9(17)10-2-4-11(5-3-10)18-13-12-6-7-19-14(12)16-8-15-13/h2-8H,1H3
  • InChiKey: CVDPZFCYGXBTPB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[4-(4-thieno[3,2-e]pyrimidinyloxy)phenyl]ethanone
  • SMR000343109
  • T5283402
  • MLS000517021
  • ZINC03361254

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens glutaminase Starlite/ChEMBL No references
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi glutaminase DH11.1 Get druggable targets OG5_129245 All targets in OG5_129245
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium ulcerans glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) glutaminase 2 Get druggable targets OG5_129245 All targets in OG5_129245
Loa Loa (eye worm) glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis glutaminase, putative Get druggable targets OG5_129245 All targets in OG5_129245
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.007 0.0267 0.0581
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0158 0.0693 0.1552
Echinococcus granulosus nuclear receptor nhr 48 0.0025 0.0047 0.0071
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0096 0.039 0.0652
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0017 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0052 0.018 0.0459
Brugia malayi Thioredoxin reductase 0.0079 0.031 0.08
Brugia malayi AMP-binding enzyme family protein 0.007 0.0267 0.0686
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0016 0.0075
Brugia malayi MH2 domain containing protein 0.0024 0.0046 0.0106
Brugia malayi Importin beta-1 subunit 0.0087 0.0351 0.0906
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0064 0.0239 0.0528
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0036 0.0038
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0052 0.018 0.0296
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0159 0.0695 0.1167
Loa Loa (eye worm) hypothetical protein 0.0022 0.0032 0.0062
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0052 0.018 0.0459
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0079 0.0125
Entamoeba histolytica hypothetical protein 0.0474 0.2221 1
Brugia malayi MH1 domain containing protein 0.0024 0.0046 0.0106
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.006 0.0218 0.0604
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0049 0.0094
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0096 0.0391 0.0653
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0079 0.031 0.0286
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.028 0.1282 0.3345
Schistosoma mansoni ap endonuclease 0.006 0.0218 0.0361
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0025 0.0052
Loa Loa (eye worm) acetyltransferase 0.0175 0.0774 0.1733
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0052 0.018 0.0395
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0023 0.0122
Brugia malayi Latrophilin receptor protein 2 0.0159 0.0695 0.1808
Schistosoma mansoni hypothetical protein 0.0049 0.0166 0.0272
Mycobacterium ulcerans fatty-acid-CoA ligase 0.007 0.0267 0.0649
Echinococcus multilocularis geminin 0.1182 0.5641 0.6945
Echinococcus multilocularis RUN 0.004 0.0123 0.0146
Echinococcus multilocularis mitogen activated protein kinase 0.0104 0.0433 0.0528
Giardia lamblia Kinase, PLK 0.0096 0.039 0.8986
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0071 0.0271 0.1752
Schistosoma mansoni alpha glucosidase 0.0035 0.0098 0.0157
Trichomonas vaginalis mercuric reductase, putative 0.0027 0.0061 0.0366
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0075 0.0293 0.0355
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0025 0.0047 0.028
Loa Loa (eye worm) acetylcholinesterase 1 0.0069 0.0261 0.0577
Loa Loa (eye worm) hypothetical protein 0.0052 0.018 0.0395
Brugia malayi hypothetical protein 0.004 0.0123 0.031
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.0267 0.0649
Loa Loa (eye worm) steroid hormone receptor 0.0052 0.018 0.0395
Echinococcus granulosus neuropeptide receptor A26 0.0476 0.223 0.3765
Schistosoma mansoni hypothetical protein 0.004 0.0123 0.02
Mycobacterium leprae Probable lipase LipE 0.0326 0.1505 0.4206
Leishmania major acetyl-CoA synthetase, putative 0.007 0.0267 0.0744
Trypanosoma brucei trypanothione reductase 0.0079 0.031 0.202
Schistosoma mansoni hypothetical protein 0.0049 0.0166 0.0272
Mycobacterium tuberculosis Conserved protein 0.0326 0.1505 0.1483
Echinococcus multilocularis protein dispatched 1 0.0058 0.021 0.0252
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0082 0.0213
Leishmania major pyruvate kinase 0.0033 0.009 0.0235
Mycobacterium ulcerans lipase LipD 0.0326 0.1505 0.3906
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.037 0.1716 0.2895
Brugia malayi beta-lactamase 0.0326 0.1505 0.3929
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0326 0.1505 0.1483
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0016 0.0075
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.009 0.0065
Schistosoma mansoni importin beta-1 0.0087 0.0351 0.0585
Echinococcus granulosus thyroid hormone receptor alpha 0.0025 0.0047 0.0071
Trypanosoma brucei hypothetical protein, conserved 0.0326 0.1505 1
Loa Loa (eye worm) glutathione reductase 0.0079 0.031 0.0688
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.007 0.0267 0.0242
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0084 0.0335 0.2227
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0023 0.0122
Onchocerca volvulus 0.0087 0.0349 0.2291
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.007 0.0267 0.1728
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0052 0.018 0.0296
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0061 0.0148
Echinococcus multilocularis ecdysone induced protein 78C 0.0052 0.018 0.0216
Loa Loa (eye worm) hypothetical protein 0.007 0.0267 0.059
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0061 0.0126
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0024 0.0046 0.005
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0025 0.0047 0.011
Echinococcus multilocularis dna polymerase kappa 0.002 0.0025 0.0025
Mycobacterium tuberculosis Probable esterase LipL 0.0326 0.1505 0.1483
Schistosoma mansoni transcription factor LCR-F1 0.0474 0.2221 0.3749
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0806 0.3821 0.8603
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.006 0.0218 0.0574
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.009 0.0546
Trichomonas vaginalis set domain proteins, putative 0.0234 0.1059 0.6942
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0201 0.0897 0.0874
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.0267 0.0649
Echinococcus granulosus mitogen activated protein kinase 3 0.0104 0.0433 0.0724
Loa Loa (eye worm) pyruvate kinase 0.0033 0.009 0.0191
Loa Loa (eye worm) hypothetical protein 0.0087 0.0351 0.078
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0023 0.0122
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0104 0.0433 0.0965
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0025 0.0132
Schistosoma mansoni hypothetical protein 0.0159 0.0695 0.1167
Loa Loa (eye worm) hypothetical protein 0.0326 0.1505 0.3381
Toxoplasma gondii HEAT repeat-containing protein 0.0087 0.0351 0.2291
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0082 0.0174
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.0816 0.5343
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0096 0.039 0.0869
Loa Loa (eye worm) hypothetical protein 0.007 0.0267 0.059
Loa Loa (eye worm) hypothetical protein 0.0025 0.0047 0.0095
Schistosoma mansoni pyruvate kinase 0.0033 0.009 0.0143
Brugia malayi MH1 domain containing protein 0.0024 0.0046 0.0106
Echinococcus multilocularis lipoxygenase domain containing protein 0.004 0.0123 0.0146
Loa Loa (eye worm) hypothetical protein 0.0051 0.0175 0.0383
Onchocerca volvulus 0.0075 0.0293 0.1919
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1695 0.8121 1
Trichomonas vaginalis CMGC family protein kinase 0.0104 0.0433 0.282
Echinococcus granulosus smad 0.0024 0.0046 0.0069
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0025 0.0113
Trichomonas vaginalis CMGC family protein kinase 0.0104 0.0433 0.282
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0025 0.0113
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0025 0.0049
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0027 0.0061 0.0351
Echinococcus granulosus neuropeptide s receptor 0.0476 0.223 0.3765
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0052 0.018 0.0459
Echinococcus granulosus pyruvate kinase 0.0033 0.009 0.0143
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0169 0.1074
Onchocerca volvulus 0.004 0.0123 0.079
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.018 0.08 0.0777
Brugia malayi orphan nuclear receptor NR2E1 0.0025 0.0047 0.011
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0223 0.037
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0082 0.0187
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0064 0.0239 0.0289
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0201 0.0897 0.0874
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.0816 0.5343
Loa Loa (eye worm) importin-beta domain-containing protein 0.0017 0.0008 0.0007
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0079 0.0125
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0052 0.018 0.0296
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0025 0.0013
Loa Loa (eye worm) nuclear receptor NHR-67 0.0025 0.0047 0.0095
Schistosoma mansoni hypothetical protein 0.0159 0.0695 0.1167
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.0774 0.1301
Loa Loa (eye worm) CXXC zinc finger family protein 0.0087 0.0349 0.0775
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0119 0.0501 0.1266
Onchocerca volvulus 0.007 0.0267 0.1745
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0023 0.0122
Brugia malayi AMP-binding enzyme family protein 0.007 0.0267 0.0686
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.0267 0.0649
Entamoeba histolytica exodeoxyribonuclease III, putative 0.006 0.0218 0.0962
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0027 0.0061 0.0069
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0049 0.0292
Trypanosoma cruzi importin beta-1 subunit, putative 0.0071 0.0271 0.0725
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.007 0.0267 0.0712
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0025 0.0025
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.0267 0.0649
Loa Loa (eye worm) hypothetical protein 0.0286 0.1308 0.2937
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.037 0.1716 0.2895
Onchocerca volvulus Protein ultraspiracle homolog 0.0052 0.018 0.1168
Onchocerca volvulus 0.0234 0.1059 0.7028
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0096 0.0391 0.0475
Trichomonas vaginalis esterase, putative 0.0326 0.1505 0.9877
Echinococcus multilocularis carboxylesterase 5A 0.0069 0.0261 0.0315
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0027 0.0061 0.0151
Echinococcus multilocularis pyruvate kinase 0.0026 0.0056 0.0063
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.007 0.0267 0.0242
Schistosoma mansoni kinase 0.0049 0.0165 0.0271
Schistosoma mansoni thyroid hormone receptor 0.0052 0.018 0.0296
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.0049 0.0055
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0061 0.0126
Toxoplasma gondii histone lysine methyltransferase SET1 0.017 0.0751 0.4961
Schistosoma mansoni smad1 5 8 and 0.0024 0.0046 0.0069
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0016 0.0075
Loa Loa (eye worm) hypothetical protein 0.0069 0.0261 0.0577
Brugia malayi nuclear receptor NHR-88 0.0052 0.018 0.0459
Brugia malayi ecdysteroid receptor 0.0052 0.018 0.0459
Schistosoma mansoni hypothetical protein 0.0022 0.0036 0.0053
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.009 0.0565
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0298 0.0495
Echinococcus multilocularis importin subunit beta 1 0.0087 0.0351 0.0426
Plasmodium vivax importin-beta 2, putative 0.0087 0.0351 0.2332
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0025 0.0132
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0016 0.0075
Brugia malayi AMP-binding enzyme family protein 0.007 0.0267 0.0686
Echinococcus granulosus GTP binding nuclear protein Ran 0.0064 0.0239 0.0396
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0098 0.0613
Brugia malayi hypothetical protein 0.0032 0.0084 0.0206
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0027 0.0061 0.0151
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0023 0.0122
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0025 0.0047 0.028
Loa Loa (eye worm) hypothetical protein 0.0025 0.0047 0.0095
Brugia malayi F/Y-rich N-terminus family protein 0.0037 0.0108 0.027
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0025 0.0113
Mycobacterium ulcerans esterase/lipase LipP 0.0326 0.1505 0.3906
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.007 0.0267 0.0712
Loa Loa (eye worm) hypothetical protein 0.0052 0.018 0.0395
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0069 0.0079
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.007 0.0267 0.0242
Echinococcus multilocularis acetylcholinesterase 0.0069 0.0261 0.0315
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.007 0.0267 0.0242
Loa Loa (eye worm) DR-78 0.0025 0.0047 0.0095
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.006 0.0218 0.1404
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0064 0.01
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.009 0.0546
Loa Loa (eye worm) hypothetical protein 0.0025 0.0047 0.0095
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.006 0.0218 0.0574
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.022 0.0484
Echinococcus granulosus tar DNA binding protein 0.0076 0.0298 0.0495
Onchocerca volvulus Bile acid receptor homolog 0.0052 0.018 0.1168
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0175 0.0287
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0075 0.0293 0.0355
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0052 0.018 0.0296
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.006 0.0218 0.0194
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0025 0.0113
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0028 0.0061 0.0095
Leishmania major pyruvate kinase 0.0033 0.009 0.0235
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0025 0.0047 0.0052
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.007 0.0267 0.0242
Schistosoma mansoni zinc finger protein 0.0025 0.0047 0.0071
Brugia malayi jmjC domain containing protein 0.0096 0.0391 0.1011
Brugia malayi Glycosyl hydrolases family 31 protein 0.0158 0.0693 0.1804
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0052 0.018 0.0296
Schistosoma mansoni FFA transport protein 0.0745 0.353 0.5964
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0175 0.1118
Loa Loa (eye worm) hypothetical protein 0.0119 0.0503 0.1122
Echinococcus granulosus lysine specific demethylase 5A 0.004 0.0123 0.02
Loa Loa (eye worm) CYP4Cod1 0.0019 0.002 0.0034
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0169 0.0434
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0052 0.018 0.0395
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0028 0.0063 0.0099
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0027 0.0061 0.0403
Toxoplasma gondii FATC domain-containing protein 0.0025 0.0049 0.0275
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.007 0.0267 0.0649
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0082 0.0095
Echinococcus granulosus dnaJ subfamily B 0.1239 0.5916 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0049 0.0116
Brugia malayi ecdysone receptor 0.0025 0.0047 0.011
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0016 0.003
Plasmodium falciparum thioredoxin reductase 0.0027 0.0061 0.1728
Mycobacterium tuberculosis Conserved protein 0.0326 0.1505 0.1483
Trichomonas vaginalis antibiotic synthetase, putative 0.007 0.0267 0.1724
Brugia malayi RNA binding protein 0.0076 0.0298 0.0767
Giardia lamblia GTOR 0.0018 0.0016 0.0124
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0098 0.0613
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0016 0.0019
Schistosoma mansoni polycystin 1-related 0.004 0.0123 0.02
Leishmania major GTP-binding protein, putative 0.0064 0.0239 0.0665
Onchocerca volvulus 0.0025 0.0047 0.028
Plasmodium falciparum glutathione reductase 0.0027 0.0061 0.1728
Brugia malayi kap beta 3 protein 0.0017 0.0008 0.0008
Onchocerca volvulus Glucosylceramidase homolog 0.0184 0.0816 0.5409
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0119 0.0501 0.0839
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0096 0.039 0.11
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0125 0.0148
Entamoeba histolytica HEAT repeat domain containing protein 0.0017 0.0008 0.0014
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.021 0.0536
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0099 0.0116
Schistosoma mansoni ap endonuclease 0.006 0.0218 0.0361
Schistosoma mansoni hypothetical protein 0.0159 0.0695 0.1167
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0045
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0175 0.0383
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0169 0.1074
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0082 0.0545
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0028 0.0061 0.0127
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.006 0.0218 0.574
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.0512 0.0857
Loa Loa (eye worm) hypothetical protein 0.0028 0.0061 0.0127
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.037 0.1716 0.2895
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.006 0.0218 0.0481
Schistosoma mansoni retinoic acid receptor RXR 0.0052 0.018 0.0296
Echinococcus granulosus sodium:myo inositol cotransporter 0.0075 0.0293 0.0487
Loa Loa (eye worm) hypothetical protein 0.0326 0.1505 0.3381
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0098 0.042
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.028 0.1282 0.2878
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.0774 0.0947
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.039 0.2538
Loa Loa (eye worm) thioredoxin reductase 0.0079 0.031 0.0688
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0075 0.0293 0.0487
Echinococcus granulosus lipoxygenase domain containing protein 0.004 0.0123 0.02
Leishmania major hypothetical protein, conserved 0.0326 0.1505 0.4307
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0029 0.0068 0.0283
Brugia malayi Cytochrome P450 family protein 0.0048 0.0159 0.0404
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0052 0.018 0.0459
Trichomonas vaginalis glucosylceramidase, putative 0.0194 0.0864 0.5658
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.009 0.0222
Toxoplasma gondii hypothetical protein 0.0029 0.0068 0.0403
Brugia malayi Nuclear hormone receptor-like 1 0.0052 0.018 0.0459
Echinococcus granulosus beta LACTamase domain containing family member 0.0326 0.1505 0.2537
Loa Loa (eye worm) hypothetical protein 0.004 0.0123 0.0267
Schistosoma mansoni importin-beta 2 0.0017 0.0008 0.0005
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.0267 0.0649
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0052 0.018 0.0459
Schistosoma mansoni hypothetical protein 0.0934 0.4441 0.7505
Echinococcus granulosus acetylcholinesterase 0.0069 0.0261 0.0433
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0025 0.0045
Plasmodium falciparum thioredoxin reductase 0.0079 0.031 0.8844
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0474 0.2221 0.3749
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0104 0.0433 0.1223
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.037 0.1716 0.2108
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0159 0.0695 0.085
Loa Loa (eye worm) hypothetical protein 0.0326 0.1505 0.3381
Loa Loa (eye worm) glutaminase 0.033 0.1523 0.3423
Echinococcus granulosus pyruvate kinase 0.0017 0.0011 0.001
Trichomonas vaginalis penicillin-binding protein, putative 0.0326 0.1505 0.9877
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.0749 0.1259
Loa Loa (eye worm) hypothetical protein 0.0025 0.0047 0.0095
Leishmania major pantothenate kinase subunit, putative 0.0022 0.0034 0.0074
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0104 0.0433 0.1186
Schistosoma mansoni Smad4 0.0024 0.0046 0.0069
Mycobacterium tuberculosis Probable lipase LipE 0.0326 0.1505 0.1483
Brugia malayi photoreceptor-specific nuclear receptor 0.0052 0.018 0.0459
Echinococcus granulosus pyruvate kinase 0.0017 0.0011 0.001
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0018 0.0016 0.0051
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0084 0.0335 0.0829
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0186 0.0825 0.1388
Schistosoma mansoni coup transcription factor 0.0052 0.018 0.0296
Trichomonas vaginalis glutaminase, putative 0.033 0.1523 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0052 0.018 0.0395
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0052 0.018 0.0459
Mycobacterium leprae possible long-chain acyl-CoA synthase 0.0736 0.3483 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0096 0.039 0.0475
Brugia malayi serine/threonine-protein kinase plk-2 0.0096 0.039 0.101
Loa Loa (eye worm) hypothetical protein 0.005 0.017 0.0373
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0023 0.0122
Echinococcus granulosus lysosomal alpha glucosidase 0.0158 0.0693 0.1165
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0123 0.02
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0028 0.0061 0.0095
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0025 0.0034
Plasmodium falciparum acetyl-CoA synthetase, putative 0.007 0.0267 0.76
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0052 0.018 0.0216
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0052 0.018 0.0395
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0064 0.0239 0.1545
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0016 0.0075
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0064 0.0239 0.0635
Mycobacterium tuberculosis Probable hydrolase 0.0326 0.1505 0.1483
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.0016 0.0024
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0025 0.0113
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.002 0.001
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0119 0.0501 0.0477
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.0267 0.0649
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0104 0.0433 0.1223
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0025 0.0025
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0098 0.0259
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0298 0.0495
Loa Loa (eye worm) hypothetical protein 0.004 0.0123 0.0267
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0052 0.018 0.0395
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.0016 0.0055
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0159 0.0695 0.1167
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0028 0.0063 0.0072
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0326 0.1505 0.2537
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0082 0.013
Giardia lamblia DINP protein human, muc B family 0.002 0.0025 0.0329
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0016 0.0075
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0016 0.0055
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0016 0.0014
Schistosoma mansoni peptidase Clp (S14 family) 0.0084 0.0335 0.0558
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0104 0.0433 0.1186
Loa Loa (eye worm) hypothetical protein 0.0326 0.1505 0.3381
Plasmodium vivax transportin, putative 0.0017 0.0008 0.0054
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0113 0.0475 0.0795
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0023 0.0122
Brugia malayi latrophilin 2 splice variant baaae 0.0343 0.1585 0.4139
Brugia malayi hypothetical protein 0.005 0.0169 0.0429
Onchocerca volvulus Serine\/threonine kinase homolog 0.0096 0.039 0.257
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0098 0.0613
Schistosoma mansoni steroid hormone receptor ad4bp 0.0052 0.018 0.0296
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.002 0.0025 0.0054
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0011 0.0318
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.0016 0.0055
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0298 0.0495
Echinococcus multilocularis neuropeptide s receptor 0.0476 0.223 0.2742
Brugia malayi hypothetical protein 0.0123 0.0524 0.136
Loa Loa (eye worm) hypothetical protein 0.0025 0.0047 0.0095
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0023 0.0122
Schistosoma mansoni pyruvate kinase 0.0017 0.0011 0.001
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.0016 0.0024
Loa Loa (eye worm) hypothetical protein 0.0062 0.023 0.0508
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.007 0.0267 0.0744
Brugia malayi hypothetical protein 0.0028 0.0061 0.0148
Giardia lamblia Kinase, CMGC MAPK 0.0104 0.0433 1
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0023 0.0122
Brugia malayi nuclear receptor NHR-88 0.0025 0.0047 0.011
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.039 0.0652
Mycobacterium ulcerans beta-lactamase 0.0326 0.1505 0.3906
Echinococcus multilocularis Smad4 0.0024 0.0046 0.005
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0025 0.009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0016 0.0075
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0016 0.0075
Plasmodium falciparum glutathione reductase 0.0079 0.031 0.8844
Loa Loa (eye worm) hypothetical protein 0.0123 0.0524 0.117
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0082 0.0494
Loa Loa (eye worm) hypothetical protein 0.007 0.0267 0.059
Schistosoma mansoni lipoxygenase 0.0113 0.0475 0.0795
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0023 0.0122
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.006 0.0218 0.4907
Leishmania major importin beta-1 subunit, putative 0.0071 0.0271 0.0756
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.002 0.0034
Echinococcus multilocularis peptidase Clp (S14 family) 0.0055 0.0195 0.0234
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0016 0.0014
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.006 0.0218 0.145
Schistosoma mansoni acetyl-CoA synthetase 0.007 0.0267 0.0443
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.0267 0.0649
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.018 0.08 0.0777
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0016 0.0075
Schistosoma mansoni alpha-glucosidase 0.0136 0.0587 0.0984
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0098 0.0613
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0025 0.0047 0.0052
Brugia malayi nuclear receptor RXR 0.0025 0.0047 0.011
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0027 0.0061 0.0094
Echinococcus granulosus Nuclear hormone receptor HR96 0.0025 0.0047 0.0071
Trichomonas vaginalis antibiotic synthetase, putative 0.007 0.0267 0.1724
Loa Loa (eye worm) hypothetical protein 0.0025 0.0047 0.0095
Mycobacterium leprae conserved hypothetical protein 0.0326 0.1505 0.4206
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0177 0.1132
Trichomonas vaginalis D-aminoacylase, putative 0.0326 0.1505 0.9877
Echinococcus multilocularis nuclear receptor nhr 48 0.0025 0.0047 0.0052
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0027 0.0061 0.0403
Brugia malayi glutaminase DH11.1 0.033 0.1523 0.3978
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0326 0.1505 0.2537
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0111 0.0463 0.1032
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0298 0.066
Schistosoma mansoni smad1 5 8 and 0.0024 0.0046 0.0069
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.007 0.0267 0.0649
Schistosoma mansoni hypothetical protein 0.0049 0.0166 0.0272
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0016 0.0075
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0025 0.0113
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.0693 0.0848
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0016 0.0075
Echinococcus granulosus transportin 1 0.0017 0.0008 0.0005
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.007 0.0267 0.0443
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0025 0.0113
Plasmodium vivax hypothetical protein, conserved 0.0326 0.1505 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0069 0.0109
Brugia malayi AMP-binding enzyme family protein 0.0806 0.3821 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0016 0.0075
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0027 0.0061 0.0151
Trichomonas vaginalis glucosylceramidase, putative 0.028 0.1282 0.8408
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0069 0.0409
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0023 0.0122
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0023 0.0122
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0098 0.0613
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0082 0.0202
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0175 0.0209
Toxoplasma gondii propionate-CoA ligase 0.007 0.0267 0.1728
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0061 0.0126
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0025 0.0113
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0104 0.0433 0.284
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0023 0.0038 0.004
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.007 0.0267 0.0649
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0052 0.018 0.0395
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0082 0.0095
Trichomonas vaginalis D-aminoacylase, putative 0.0326 0.1505 0.9877
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0025 0.0047 0.0071
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0082 0.0494
Brugia malayi AMP-binding enzyme family protein 0.007 0.0267 0.0686
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.007 0.0267 0.0649
Echinococcus granulosus serine protein kinase ATM 0.0025 0.0049 0.0075
Echinococcus granulosus peregrin 0.0034 0.009 0.0144
Onchocerca volvulus 0.0078 0.0305 0.2002
Loa Loa (eye worm) oxidoreductase 0.007 0.0267 0.059
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.007 0.0267 0.0649
Echinococcus granulosus dna polymerase eta 0.002 0.0025 0.0034
Echinococcus multilocularis high affinity choline transporter 1 0.0075 0.0293 0.0355
Brugia malayi steroid hormone receptor 0.0052 0.018 0.0459
Mycobacterium ulcerans hypothetical protein 0.0326 0.1505 0.3906
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.007 0.0267 0.0649
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0052 0.018 0.0459
Echinococcus granulosus cpg binding protein 0.0092 0.0373 0.0622
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0023 0.0122
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0025 0.0113
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0119 0.0501 0.1266
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0016 0.0075
Schistosoma mansoni nuclear hormone receptor 0.0052 0.018 0.0296
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0016 0.0019
Brugia malayi Nuclear hormone receptor E75 0.0025 0.0047 0.011
Onchocerca volvulus 0.0058 0.021 0.1365
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.037 0.1716 0.2895
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.0816 0.5343
Echinococcus granulosus sodium:glucose cotransporter 2 0.0075 0.0293 0.0487
Onchocerca volvulus 0.0326 0.1505 1
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.007 0.0267 0.1728
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.0503 0.0613
Trypanosoma cruzi hypothetical protein, conserved 0.0326 0.1505 0.4236
Mycobacterium ulcerans acetyl-CoA synthetase 0.007 0.0267 0.0649
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.007 0.0267 0.0649
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0119 0.0501 0.0611
Trypanosoma brucei unspecified product 0.002 0.0025 0.0113
Brugia malayi nuclear hormone receptor family member nhr-6 0.0025 0.0047 0.011
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0025 0.0113
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.0749 0.0917
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0027 0.0061 0.1728
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0025 0.0047 0.0071
Loa Loa (eye worm) hypothetical protein 0.0501 0.2351 0.5289
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.0082 0.0057
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0223 0.037
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0016 0.0019
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.039 0.2538
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.007 0.0267 0.0649
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0018 0.0016 0.0024
Loa Loa (eye worm) Smad1 0.0024 0.0046 0.0092
Trypanosoma cruzi hypothetical protein, conserved 0.0326 0.1505 0.4236
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0082 0.0095
Loa Loa (eye worm) hypothetical protein 0.0025 0.0047 0.0095
Echinococcus multilocularis neuropeptide receptor A26 0.0476 0.223 0.2742
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0027 0.0061 0.0126
Loa Loa (eye worm) beta-lactamase 0.0326 0.1505 0.3381
Echinococcus granulosus pyruvate kinase 0.0017 0.0011 0.001
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.0267 0.0649
Brugia malayi nuclear receptor NHR-67 0.0025 0.0047 0.011
Schistosoma mansoni loxhd1 0.004 0.0123 0.02
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0064 0.0239 0.1591
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0027 0.0061 0.0351
Loa Loa (eye worm) transcription factor SMAD2 0.0357 0.1651 0.3711
Schistosoma mansoni lipoxygenase 0.004 0.0123 0.02
Brugia malayi nuclear hormone receptor 0.0025 0.0047 0.011
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0079 0.0125
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0159 0.1016
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0025 0.0025
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0223 0.062
Brugia malayi exodeoxyribonuclease III family protein 0.006 0.0218 0.0559
Plasmodium falciparum LCCL domain-containing protein 0.004 0.0123 0.3518
Schistosoma mansoni cpg binding protein 0.0092 0.0373 0.0622
Schistosoma mansoni nuclear receptor 0.0025 0.0047 0.0071
Brugia malayi Sodium:solute symporter family protein 0.0075 0.0293 0.0754
Trypanosoma brucei importin beta-1 subunit, putative 0.0087 0.0351 0.2291
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.0816 0.5343
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0018 0.0014 0.004
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0075 0.0293 0.1902
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0104 0.0433 0.284
Brugia malayi RNA, U transporter 1 0.0249 0.113 0.2949
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0806 0.3821 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0061 0.0127
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0064 0.0239 0.682
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0501 0.2351 0.6147
Echinococcus granulosus dna polymerase kappa 0.002 0.0025 0.0034
Plasmodium falciparum importin beta, putative 0.0087 0.0351 1
Echinococcus granulosus acetylcholinesterase 0.0069 0.0261 0.0433
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0028 0.0061 0.0069
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0223 0.0269
Loa Loa (eye worm) hypothetical protein 0.0052 0.018 0.0395
Entamoeba histolytica hypothetical protein 0.0474 0.2221 1
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0084 0.0335 1
Schistosoma mansoni RAR-like nuclear receptor 0.0052 0.018 0.0296
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0027 0.0061 0.0351
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.075 0.1261
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0064 0.0239 0.5407
Schistosoma mansoni hypothetical protein 0.0058 0.021 0.0346
Schistosoma mansoni nuclear hormone receptor 0.0025 0.0047 0.0071
Onchocerca volvulus 0.0326 0.1505 1
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0025 0.0025
Echinococcus granulosus carboxylesterase 5A 0.0069 0.0261 0.0433
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0104 0.0433 0.1186
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0023 0.0122
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0084 0.0335 1
Onchocerca volvulus 0.0326 0.1505 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0069 0.0145
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.0693 0.0848
Echinococcus multilocularis thioredoxin glutathione reductase 0.008 0.0315 0.0383
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0036 0.0053
Leishmania major fatty acid transporter protein-like protein 0.0736 0.3483 1
Schistosoma mansoni nuclear receptor 0.0025 0.0047 0.0071
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0084 0.0335 0.0781
Brugia malayi nuclear receptor RXR 0.0028 0.0061 0.0148
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0016 0.0075
Echinococcus multilocularis pyruvate kinase 0.0017 0.0011 0.0008
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0052 0.018 0.0216
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.007 0.0267 0.0242
Leishmania major DNA polymerase kappa, putative 0.002 0.0025 0.0049
Echinococcus multilocularis cpg binding protein 0.0092 0.0373 0.0453
Echinococcus multilocularis pyruvate kinase 0.0033 0.009 0.0104
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.009 0.0209
Trichomonas vaginalis ap endonuclease, putative 0.006 0.0218 0.1404
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0298 0.0495
Loa Loa (eye worm) hypothetical protein 0.0075 0.0293 0.0649
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0023 0.0038 0.004
Schistosoma mansoni thyroid hormone receptor 0.0052 0.018 0.0296
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0029 0.0068 0.0455
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0177 0.1132
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0041 0.0162
Plasmodium vivax SET domain protein, putative 0.0031 0.0079 0.0523
Loa Loa (eye worm) hypothetical protein 0.0159 0.0695 0.1555
Echinococcus multilocularis solute carrier family 5 0.0075 0.0293 0.0355
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0119 0.0501 0.13
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0082 0.0187
Schistosoma mansoni alpha-glucosidase 0.0136 0.0587 0.0984
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.0156 0.3437
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0326 0.1505 0.1483
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.007 0.0267 0.1728
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.0816 0.5343
Echinococcus granulosus lipoxygenase domain containing protein 0.004 0.0123 0.02
Plasmodium vivax glutathione reductase, putative 0.0079 0.031 0.2063
Brugia malayi conserved hypotetical protein 0.0025 0.0047 0.011
Trichomonas vaginalis glucosylceramidase, putative 0.028 0.1282 0.8408
Loa Loa (eye worm) cytochrome P450 family protein 0.0048 0.0159 0.0348
Echinococcus granulosus geminin 0.1182 0.5641 0.9536
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.039 0.1064
Trypanosoma cruzi trypanothione reductase, putative 0.0027 0.0061 0.0126
Trichomonas vaginalis glucosylceramidase, putative 0.0194 0.0864 0.5658
Loa Loa (eye worm) hypothetical protein 0.0075 0.0293 0.0649
Loa Loa (eye worm) hypothetical protein 0.0031 0.0079 0.0166
Mycobacterium tuberculosis Probable reductase 0.018 0.08 0.0777
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0159 0.1016
Loa Loa (eye worm) doublecortin family protein 0.004 0.0123 0.0267
Schistosoma mansoni inositol transporter 0.0075 0.0293 0.0487
Entamoeba histolytica acyl-coA synthetase, putative 0.007 0.0267 0.1181
Schistosoma mansoni hypothetical protein 0.1182 0.5641 0.9536
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0018 0.0016 0.0051
Brugia malayi Cytochrome P450 family protein 0.0019 0.002 0.0039
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0156 0.4451
Toxoplasma gondii NADPH-glutathione reductase 0.0027 0.0061 0.0351
Entamoeba histolytica serine/threonine protein kinase, putative 0.0096 0.039 0.1739
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 0.0267 0.0686
Brugia malayi CXXC zinc finger family protein 0.0087 0.0349 0.09
Brugia malayi MH2 domain containing protein 0.0357 0.1651 0.4313
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.007 0.0267 0.0581
Schistosoma mansoni ran 0.0064 0.0239 0.0396
Echinococcus granulosus pyruvate kinase 0.0033 0.009 0.0143
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0025 0.0034
Loa Loa (eye worm) hypothetical protein 0.0025 0.0047 0.0095
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.039 0.2538
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0082 0.0494
Loa Loa (eye worm) AMP-binding enzyme family protein 0.007 0.0267 0.059
Brugia malayi jmjC domain containing protein 0.004 0.0123 0.0309
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0082 0.0095
Echinococcus multilocularis beta LACTamase domain containing family member 0.0326 0.1505 0.1848
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0027 0.0061 0.0146
Entamoeba histolytica hypothetical protein 0.0474 0.2221 1
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.0503 0.1304
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0052 0.018 0.0459
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0016 0.0026
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0023 0.0122
Echinococcus granulosus mitogen activated protein kinase 0.0104 0.0433 0.0724
Loa Loa (eye worm) hypothetical protein 0.0052 0.018 0.0395
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0027 0.0061 0.0107
Brugia malayi follicle stimulating hormone receptor 0.024 0.1089 0.2841
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.006 0.0218 0.6218
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0169 0.1122
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0041 0.0081
Brugia malayi nuclear hormone receptor 0.0052 0.018 0.0459
Echinococcus multilocularis acetylcholinesterase 0.0069 0.0261 0.0315
Trichomonas vaginalis hypothetical protein 0.0017 0.0008 0.0021
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.0016 0.0055
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.002 0.001
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0098 0.021
Brugia malayi acetyl-Coenzyme A synthetase 2 0.007 0.0267 0.0686
Echinococcus multilocularis translational activator gcn1 0.0017 0.0008 0.0004
Onchocerca volvulus 0.0052 0.018 0.1168
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0084 0.0335 0.9549
Trichomonas vaginalis CMGC family protein kinase 0.0104 0.0433 0.282
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0098 0.0613
Loa Loa (eye worm) MH2 domain-containing protein 0.0024 0.0046 0.0092
Loa Loa (eye worm) hypothetical protein 0.0025 0.0047 0.0095
Echinococcus multilocularis pyruvate kinase 0.0017 0.0011 0.0008
Entamoeba histolytica hypothetical protein 0.0071 0.0271 0.12
Mycobacterium tuberculosis Putative ferredoxin reductase 0.018 0.08 0.0777
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0025 0.0047 0.0052
Treponema pallidum exodeoxyribonuclease (exoA) 0.006 0.0218 0.574
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0098 0.0157
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0098 0.0613
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.007 0.0267 0.0242
Echinococcus multilocularis GPCR, family 2 0.0159 0.0695 0.085
Loa Loa (eye worm) hypothetical protein 0.0052 0.018 0.0395
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.039 0.2538
Trypanosoma cruzi trypanothione reductase, putative 0.0079 0.031 0.0837
Schistosoma mansoni hypothetical protein 0.1239 0.5916 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0052 0.018 0.0459
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0169 0.4811
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0016 0.0075
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0025 0.0049 0.0275
Trichomonas vaginalis importin beta-1, putative 0.0071 0.0271 0.1752
Echinococcus multilocularis transportin 1 0.0017 0.0008 0.0004
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.006 0.0218 0.0361
Brugia malayi hypothetical protein 0.0025 0.0047 0.011
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0025 0.0113
Brugia malayi Pre-SET motif family protein 0.0206 0.0923 0.2405
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0098 0.0613
Brugia malayi Nuclear hormone receptor E75 0.0025 0.0047 0.011
Echinococcus multilocularis dna polymerase eta 0.002 0.0025 0.0025
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.009 0.0209
Echinococcus granulosus long chain fatty acid transport protein 4 0.0745 0.353 0.5964
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0177 0.1128
Brugia malayi GH02984p 0.0075 0.0293 0.0754
Trichomonas vaginalis ran, putative 0.0064 0.0239 0.1543
Trypanosoma brucei polo-like protein kinase 0.0096 0.039 0.2554
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0082 0.2337
Schistosoma mansoni sodium/solute symporter 0.0075 0.0293 0.0487
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0159 0.0695 0.085
Loa Loa (eye worm) hypothetical protein 0.0123 0.0524 0.117
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0052 0.018 0.0296
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0025 0.0047 0.0052
Plasmodium falciparum phd finger protein, putative 0.0029 0.0069 0.1979
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.007 0.0267 0.0581
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0052 0.018 0.0296
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.0816 0.5343
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0082 0.0494
Entamoeba histolytica acyl-CoA synthetase, putative 0.007 0.0267 0.1181
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0326 0.1505 0.1483
Echinococcus multilocularis FTZ F1 alpha 0.0052 0.018 0.0216
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.009 0.0222
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0016 0.0075
Loa Loa (eye worm) hypothetical protein 0.0052 0.018 0.0395
Leishmania major acetyl-CoA synthetase, putative 0.007 0.0267 0.0744
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0175 0.0287
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0079 0.0472
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.0049 0.0075
Brugia malayi hypothetical protein 0.004 0.0123 0.031
Brugia malayi Probable ClpP-like protease 0.0084 0.0335 0.0865
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0934 0.4441 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0041 0.0081
Schistosoma mansoni serine/threonine protein kinase 0.0104 0.0433 0.0724
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0736 0.3483 0.3467
Echinococcus granulosus sodium:glucose cotransporter 0.0075 0.0293 0.0487
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0025 0.0052
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.0267 0.0649
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.007 0.0267 0.0242
Loa Loa (eye worm) MH1 domain-containing protein 0.0024 0.0046 0.0092
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0052 0.018 0.0216
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0071 0.0271 0.1752
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0075 0.0293 0.0355
Echinococcus granulosus Polycystic kidney disease protein 0.004 0.0123 0.02
Onchocerca volvulus 0.007 0.0267 0.1745
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0027 0.0061 0.0351
Schistosoma mansoni hypothetical protein 0.0474 0.2221 0.3749
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0125 0.0203
Leishmania major hypothetical protein, conserved 0.005 0.0169 0.0462
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0011 0.0074
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0082 0.0095
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0069 0.0409
Echinococcus multilocularis peregrin 0.0034 0.009 0.0105
Schistosoma mansoni cpg binding protein 0.0092 0.0373 0.0622
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0032 0.0084 0.0134
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0027 0.0061 0.0036
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0113 0.0475 0.0579
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.0267 0.0649
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0061 0.0126
Echinococcus granulosus translational activator gcn1 0.0017 0.0008 0.0005
Loa Loa (eye worm) hypothetical protein 0.0052 0.018 0.0395
Loa Loa (eye worm) pyruvate kinase 0.0033 0.009 0.0191
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0123 0.0266
Loa Loa (eye worm) hypothetical protein 0.0025 0.0047 0.0095
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0023 0.0122
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.1308 0.2204
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.006 0.022 0.0195
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.002 0.0034
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.007 0.0267 0.0649
Brugia malayi glutathione reductase 0.0079 0.031 0.08
Loa Loa (eye worm) histone methyltransferase 0.0028 0.0063 0.0132
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0016 0.0019
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.037 0.1716 0.3857
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0084 0.0335 0.0558
Onchocerca volvulus 0.0092 0.0371 0.2439
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.0016 0.0024
Entamoeba histolytica Ran family GTPase 0.0064 0.0239 0.1058
Echinococcus granulosus importin 5 0.0017 0.0008 0.0005
Echinococcus granulosus RUN 0.004 0.0123 0.02
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0298 0.0495
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.006 0.0218 0.0521
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0169 0.0434
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.007 0.0267 0.0712
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0177 0.0291
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.0267 0.0649
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.0177 0.1176
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0025 0.0034
Echinococcus granulosus thioredoxin glutathione reductase 0.008 0.0315 0.0525
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.007 0.0267 0.0242
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.039 0.2538
Loa Loa (eye worm) hypothetical protein 0.0028 0.0061 0.0127
Schistosoma mansoni patched 1 0.0051 0.0175 0.0287
Echinococcus granulosus importin subunit beta 1 0.0087 0.0351 0.0585
Echinococcus granulosus solute carrier family 5 0.0075 0.0293 0.0487
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0016 0.0075
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.009 0.0565
Loa Loa (eye worm) hypothetical protein 0.0052 0.018 0.0395
Loa Loa (eye worm) kap beta 3 protein 0.0017 0.0008 0.0007
Chlamydia trachomatis pyruvate kinase 0.0033 0.009 0.1062
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0079 0.0091
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0016 0.0075
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.009 0.0559
Loa Loa (eye worm) RNA binding protein 0.0076 0.0298 0.066
Loa Loa (eye worm) hypothetical protein 0.005 0.0169 0.0369
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0098 0.042
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0027 0.0061 0.0126
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0119 0.0501 0.0839
Schistosoma mansoni DNA polymerase eta 0.002 0.0025 0.0034
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0159 0.0695 0.1808
Loa Loa (eye worm) hypothetical protein 0.0069 0.0261 0.0577
Echinococcus multilocularis pyruvate kinase 0.0017 0.0011 0.0008
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0098 0.0244
Trichomonas vaginalis glutathione reductase, putative 0.0027 0.0061 0.0366
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0025 0.0013
Plasmodium falciparum transportin 0.0017 0.0008 0.0233
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0052 0.018 0.0216
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.037 0.1716 0.2895
Loa Loa (eye worm) hypothetical protein 0.0326 0.1505 0.3381
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0501 0.2351 0.5289
Loa Loa (eye worm) hypothetical protein 0.0028 0.0061 0.0127
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.007 0.0267 0.0242
Brugia malayi Doublecortin family protein 0.004 0.0123 0.031
Echinococcus granulosus ecdysone induced protein 78C 0.0052 0.018 0.0296
Loa Loa (eye worm) hypothetical protein 0.0084 0.0335 0.0744
Schistosoma mansoni smad 0.0024 0.0046 0.0069
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0064 0.0239 0.0635
Toxoplasma gondii thioredoxin reductase 0.0079 0.031 0.202
Brugia malayi hypothetical protein 0.0286 0.1308 0.3414
Loa Loa (eye worm) pyruvate kinase 0.0033 0.009 0.0191
Giardia lamblia PHD finger protein 15 0.0029 0.0069 0.1381
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.007 0.0267 0.0242
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0055 0.0195 0.0371
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0084 0.0335 0.2185
Brugia malayi Bromodomain containing protein 0.0034 0.009 0.0223
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0061 0.0148
Echinococcus multilocularis mitogen activated protein kinase 3 0.0104 0.0433 0.0528
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0016 0.0075
Brugia malayi hypothetical protein 0.0025 0.0047 0.011
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0326 0.1505 0.3929
Brugia malayi isocitrate dehydrogenase 0.0032 0.0082 0.0202
Loa Loa (eye worm) hypothetical protein 0.0025 0.0047 0.0095
Loa Loa (eye worm) hypothetical protein 0.007 0.0267 0.059
Echinococcus multilocularis importin 5 0.0017 0.0008 0.0004
Schistosoma mansoni ran 0.0064 0.0239 0.0396
Echinococcus multilocularis pyruvate kinase 0.0033 0.009 0.0104
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0061 0.0126
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.037 0.1716 0.2108
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0104 0.0433 0.1186
Echinococcus multilocularis snurportin 1 0.0934 0.4441 0.5466
Loa Loa (eye worm) hypothetical protein 0.0326 0.1505 0.3381
Mycobacterium tuberculosis Probable lipase LipD 0.0326 0.1505 0.1483
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.006 0.0218 0.0263
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0069 0.0261 0.0433
Trypanosoma brucei importin beta-1 subunit, putative 0.0087 0.0351 0.2291
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0025 0.0047 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0052 0.018 0.0459
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0027 0.0061 0.1728
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0011 0.002
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.0923 0.2069
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.007 0.0267 0.0581
Onchocerca volvulus Alhambra homolog 0.0029 0.0069 0.043
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.0745 0.353 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0047 0.0095
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0326 0.1505 0.3906
Schistosoma mansoni jumonji domain containing protein 0.0076 0.0296 0.0492
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.039 0.2538
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0052 0.018 0.0296
Brugia malayi AMP-binding enzyme family protein 0.007 0.0267 0.0686
Schistosoma mansoni survival motor neuron protein 0.0058 0.021 0.0346
Echinococcus granulosus snurportin 1 0.0934 0.4441 0.7505
Echinococcus granulosus Nuclear hormone receptor HR96 0.0025 0.0047 0.0071
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0025 0.0047 0.0071
Schistosoma mansoni hypothetical protein 0.0049 0.0166 0.0272
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0079 0.0125
Brugia malayi Steroid receptor seven-up type 2 0.0052 0.018 0.0459
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0079 0.0125
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0052 0.018 0.0459
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.018 0.08 0.2143
Loa Loa (eye worm) glutaminase 2 0.033 0.1523 0.3423
Trichomonas vaginalis helicase, putative 0.002 0.0023 0.0122
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0326 0.1505 0.3381
Brugia malayi MAP kinase sur-1 0.0104 0.0433 0.1122
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0098 0.0232
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0223 0.1439
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0023 0.0038 0.0056
Loa Loa (eye worm) hypothetical protein 0.0343 0.1585 0.3561
Echinococcus granulosus high affinity choline transporter 1 0.0075 0.0293 0.0487
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0052 0.018 0.1168
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0028 0.0061 0.0095
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.039 0.1064
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.0745 0.353 1
Leishmania major DNA polymerase eta, putative 0.002 0.0025 0.0049
Brugia malayi Pre-SET motif family protein 0.0031 0.0079 0.0193
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.0816 0.5343
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0052 0.018 0.0296
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0082 0.013
Brugia malayi beta-lactamase family protein 0.0326 0.1505 0.3929
Loa Loa (eye worm) hypothetical protein 0.0033 0.009 0.0191
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0025 0.0025
Brugia malayi Cytochrome P450 family protein 0.0019 0.002 0.0039
Plasmodium vivax pyruvate kinase, putative 0.0033 0.009 0.0597
Brugia malayi beta-lactamase family protein 0.0326 0.1505 0.3929
Onchocerca volvulus 0.0031 0.0079 0.0492
Echinococcus granulosus FTZ F1 alpha 0.0052 0.018 0.0296
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0474 0.2221 0.273
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0025 0.0025
Trichomonas vaginalis glucosylceramidase, putative 0.028 0.1282 0.8408
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0052 0.018 0.0216
Leishmania major trypanothione reductase 0.0079 0.031 0.087
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.007 0.0267 0.0649
Toxoplasma gondii ABC1 family protein 0.0326 0.1505 1
Leishmania major 4-coumarate:coa ligase-like protein 0.007 0.0267 0.0744
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.039 0.2538
Mycobacterium tuberculosis Conserved protein 0.0326 0.1505 0.1483
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0223 0.037
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0027 0.0061 0.0094
Brugia malayi MH2 domain containing protein 0.0024 0.0046 0.0106
Schistosoma mansoni hypothetical protein 0.0343 0.1585 0.2672
Brugia malayi CHE-14 protein 0.0051 0.0175 0.0445
Schistosoma mansoni pyruvate kinase 0.0033 0.009 0.0143
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0055 0.0195 0.017
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0052 0.018 0.0459
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0055 0.0195 0.017
Brugia malayi Smad1 0.0024 0.0046 0.0106
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0016 0.0075
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.1308 0.1606
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.037 0.1716 0.4483
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0169 0.4811
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0016 0.0075
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0223 0.0199
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.009 0.0565
Loa Loa (eye worm) latrophilin receptor protein 2 0.0159 0.0695 0.1555
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0023 0.0122
Giardia lamblia NADH oxidase lateral transfer candidate 0.0027 0.0061 0.1173
Leishmania major 4-coumarate:coa ligase-like protein 0.007 0.0267 0.0744
Echinococcus multilocularis mothers against decapentaplegic 5 0.0024 0.0046 0.005
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0064 0.0239 0.0614
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0027 0.0061 0.0107
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0061 0.0126
Schistosoma mansoni hypothetical protein 0.0159 0.0695 0.1167
Loa Loa (eye worm) hypothetical protein 0.0028 0.0061 0.0127
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0084 0.0335 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0052 0.018 0.0216
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0016 0.0075
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0084 0.0335 0.0829
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0201 0.0897 0.2427
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0079 0.0091
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0223 0.0535
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0156 0.0682
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0123 0.02
Echinococcus multilocularis protein patched 0.0051 0.0175 0.0209
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0024 0.0046 0.0069
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.007 0.0267 0.1181
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0052 0.018 0.0296
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0052 0.018 0.0296
Onchocerca volvulus 0.007 0.0267 0.1745
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0022 0.0034 0.005
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0223 0.0535
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.0503 0.2246
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.018 0.08 0.0777
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0029 0.0068 0.1949
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0052 0.018 0.0395
Trichomonas vaginalis ap endonuclease, putative 0.006 0.0218 0.1404
Brugia malayi Carboxylesterase family protein 0.0069 0.0261 0.067
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.007 0.0267 0.0322
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0025 0.0113
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.002 0.0025 0.0054
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0069 0.0461
Trichomonas vaginalis glucosylceramidase, putative 0.028 0.1282 0.8408
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0027 0.0061 0.0107
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.007 0.0267 0.0242
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.0016 0.0024
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0084 0.0335 0.0407
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0119 0.0501 0.1419
Toxoplasma gondii exonuclease III APE 0.006 0.0218 0.1404
Schistosoma mansoni hypothetical protein 0.0029 0.0069 0.0109
Onchocerca volvulus 0.004 0.0123 0.079
Mycobacterium tuberculosis Probable dehydrogenase 0.018 0.08 0.0777
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0025 0.0113
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0016 0.0075
Loa Loa (eye worm) MH2 domain-containing protein 0.0357 0.1651 0.3711
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0177 0.1128
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0016 0.0075
Toxoplasma gondii target of rapamycin (TOR), putative 0.0018 0.0016 0.0055
Brugia malayi Calcitonin receptor-like protein seb-1 0.0501 0.2351 0.6147
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0016 0.003
Loa Loa (eye worm) carboxylesterase 0.0069 0.0261 0.0577
Schistosoma mansoni cpg binding protein 0.0087 0.0349 0.0581
Trypanosoma brucei acetyl-CoA synthetase, putative 0.007 0.0267 0.1728
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.0774 0.2015
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.007 0.0267 0.0712
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0016 0.0026
Schistosoma mansoni rab6-interacting 0.004 0.0123 0.02
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0069 0.0145
Leishmania major 4-coumarate:coa ligase-like protein 0.007 0.0267 0.0744
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0069 0.0109
Echinococcus multilocularis dnaJ subfamily B 0.1239 0.5916 0.7283
Echinococcus multilocularis lipoxygenase domain containing protein 0.004 0.0123 0.0146
Brugia malayi PHD-finger family protein 0.0029 0.0069 0.0169
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0052 0.018 0.0459
Schistosoma mansoni inositol transporter 0.0075 0.0293 0.0487
Plasmodium vivax acetyl-CoA synthetase, putative 0.007 0.0267 0.1772
Entamoeba histolytica hypothetical protein 0.0025 0.0049 0.02
Schistosoma mansoni smad1 5 8 and 0.0024 0.0046 0.0069
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0016 0.0075
Plasmodium vivax multidomain scavenger receptor, putative 0.004 0.0123 0.0821
Echinococcus granulosus Smad4 0.0024 0.0046 0.0069
Trypanosoma brucei glucosidase, putative 0.0035 0.0098 0.06
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0016 0.0075
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0027 0.0061 0.0151
Brugia malayi TAR-binding protein 0.0076 0.0298 0.0767
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0098 0.0613
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0223 0.0535
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0084 0.0335 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0052 0.018 0.0296
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0298 0.0767
Brugia malayi tailless protein 0.0025 0.0047 0.011
Brugia malayi nuclear hormone receptor family member odr-7 0.0025 0.0047 0.011
Leishmania major cytochrome p450-like protein 0.0019 0.002 0.0034
Mycobacterium tuberculosis Probable oxidoreductase 0.0201 0.0897 0.0874
Loa Loa (eye worm) hypothetical protein 0.0025 0.0047 0.0095
Echinococcus granulosus expressed conserved protein 0.0112 0.0468 0.0783
Mycobacterium ulcerans pyruvate kinase 0.0033 0.009 0.0184
Onchocerca volvulus 0.0025 0.0047 0.028
Loa Loa (eye worm) hypothetical protein 0.007 0.0267 0.059
Loa Loa (eye worm) follicle stimulating hormone receptor 0.024 0.1089 0.2444
Echinococcus multilocularis smad 0.0024 0.0046 0.005
Echinococcus multilocularis expressed conserved protein 0.0112 0.0468 0.057
Echinococcus granulosus TGF beta signal transducer SmadC 0.0024 0.0046 0.0069
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0098 0.0232
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0025 0.0047 0.0052
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0025 0.0113
Entamoeba histolytica acyl-CoA synthetase, putative 0.007 0.0267 0.1181
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0016 0.0075
Brugia malayi hypothetical protein 0.0474 0.2221 0.5806
Giardia lamblia Pyruvate kinase 0.0033 0.009 0.1864
Onchocerca volvulus 0.007 0.0267 0.1745
Trypanosoma brucei cytochrome P450, putative 0.0019 0.002 0.0079
Schistosoma mansoni glutaminase 0.033 0.1523 0.2569
Loa Loa (eye worm) nuclear hormone receptor 0.0025 0.0047 0.0095
Echinococcus granulosus mixed lineage leukemia protein mll 0.0023 0.0038 0.0056
Plasmodium vivax thioredoxin reductase, putative 0.0079 0.031 0.2063
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.0503 0.0842
Trichomonas vaginalis CMGC family protein kinase 0.0104 0.0433 0.282
Trichomonas vaginalis glucosylceramidase, putative 0.028 0.1282 0.8408
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0016 0.0055
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.009 0.0559
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0016 0.0075
Brugia malayi AMP-binding enzyme family protein 0.007 0.0267 0.0686
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0016 0.0075
Echinococcus granulosus peptidase Clp S14 family 0.0055 0.0195 0.0321
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.007 0.0267 0.0242
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.007 0.0267 0.0581
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0052 0.018 0.0296
Schistosoma mansoni hypothetical protein 0.1182 0.5641 0.9536
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0052 0.018 0.0216
Trypanosoma brucei pyruvate kinase 1 0.0033 0.009 0.0546
Schistosoma mansoni nuclear hormone receptor 0.0025 0.0047 0.0071
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.009 0.0063
Mycobacterium ulcerans hypothetical protein 0.007 0.0267 0.0649
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0064 0.0239 0.1545
Echinococcus multilocularis long chain fatty acid transport protein 4 0.0745 0.353 0.4343
Onchocerca volvulus Huntingtin homolog 0.0123 0.0524 0.346
Trichomonas vaginalis glucosylceramidase, putative 0.028 0.1282 0.8408
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0084 0.0335 0.2185
Entamoeba histolytica hypothetical protein 0.0474 0.2221 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0098 0.06
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0025 0.0047 0.0095
Plasmodium falciparum pyruvate kinase 0.0033 0.009 0.2559
Trypanosoma brucei protein kinase, putative 0.0104 0.0433 0.284
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0027 0.0061 0.0351
Echinococcus granulosus mothers against decapentaplegic 5 0.0024 0.0046 0.0069
Trichomonas vaginalis penicillin-binding protein, putative 0.0326 0.1505 0.9877
Schistosoma mansoni rab6-interacting 0.004 0.0123 0.02
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.0032 0.0045
Brugia malayi hypothetical protein 0.0028 0.0061 0.0148
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0298 0.066
Echinococcus granulosus GPCR family 2 0.0159 0.0695 0.1167
Brugia malayi Carboxylesterase family protein 0.0069 0.0261 0.067
Mycobacterium ulcerans glutaminase 0.033 0.1523 0.3955
Onchocerca volvulus Huntingtin homolog 0.0123 0.0524 0.346
Echinococcus multilocularis Polycystic kidney disease protein 0.004 0.0123 0.0146
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0298 0.0361
Schistosoma mansoni nuclear receptor nhr-48 0.0025 0.0047 0.0071
Schistosoma mansoni high-affinity choline transporter 0.0075 0.0293 0.0487
Trichomonas vaginalis D-aminoacylase, putative 0.0326 0.1505 0.9877
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0098 0.0115

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 33.211 um PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Response HTS to Identify Activators of 5'UTR Stem-Loop Driven Prion Protein mRNA Translation in H4 Neuroglioblastoma Cells. (Class of assay: confirmatory) [Related pubchem assays: 1829 (Project Summary), 1814 (Primary HTS)] ChEMBL. No reference
Potency (functional) 0.7943 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) = 2.8184 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.8184 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.3225 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 12.99 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3535 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 21.3313 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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