Detailed information for compound 1357784

Basic information

Technical information
  • TDR Targets ID: 1357784
  • Name: 4-[(4-acetylphenyl)sulfonyl-methylamino]-N-(1 ,3-benzodioxol-5-ylmethyl)butanamide
  • MW: 432.49 | Formula: C21H24N2O6S
  • H donors: 1 H acceptors: 4 LogP: 1.67 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NCc1ccc2c(c1)OCO2)CCCN(S(=O)(=O)c1ccc(cc1)C(=O)C)C
  • InChi: 1S/C21H24N2O6S/c1-15(24)17-6-8-18(9-7-17)30(26,27)23(2)11-3-4-21(25)22-13-16-5-10-19-20(12-16)29-14-28-19/h5-10,12H,3-4,11,13-14H2,1-2H3,(H,22,25)
  • InChiKey: ZCMNITNVBSVTLH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[(4-acetylphenyl)sulfonyl-methyl-amino]-N-(1,3-benzodioxol-5-ylmethyl)butanamide
  • 4-[(4-acetylphenyl)sulfonyl-methyl-amino]-N-(1,3-benzodioxol-5-ylmethyl)butyramide
  • N-(1,3-benzodioxol-5-ylmethyl)-4-[(4-ethanoylphenyl)sulfonyl-methyl-amino]butanamide
  • T5532612

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica protein kinase, putative 0.013 0.0269 0.1082
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0174 0.0494 0.0535
Schistosoma mansoni vesicular amine transporter 0.0149 0.0367 0.0774
Trichomonas vaginalis CAMK family protein kinase 0.0241 0.0835 0.3217
Schistosoma mansoni serine/threonine kinase 0.03 0.1135 0.2393
Onchocerca volvulus 0.0115 0.0193 0.044
Loa Loa (eye worm) hypothetical protein 0.0154 0.0391 0.0423
Entamoeba histolytica protein kinase 2, putative 0.0302 0.1146 0.4614
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0176 0.0504 0.0609
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.0889 0.0963
Loa Loa (eye worm) hypothetical protein 0.0281 0.1038 0.1124
Schistosoma mansoni tyrosine kinase 0.056 0.2462 0.519
Giardia lamblia Kinase, NEK 0.026 0.0935 0.368
Onchocerca volvulus 0.0304 0.1156 0.2689
Schistosoma mansoni adapter molecule crk 0.0134 0.029 0.0611
Trichomonas vaginalis STE family protein kinase 0.0156 0.0405 0.145
Brugia malayi Immunoglobulin I-set domain containing protein 0.0087 0.0053 0.0057
Trichomonas vaginalis AGC family protein kinase 0.0564 0.2485 1
Brugia malayi hypothetical protein 0.0078 0.0005 0.0005
Entamoeba histolytica protein kinase, putative 0.055 0.241 0.9701
Brugia malayi Protein kinase domain containing protein 0.0593 0.2632 0.285
Trichomonas vaginalis CMGC family protein kinase 0.0159 0.0419 0.1506
Trichomonas vaginalis CAMK family protein kinase 0.0532 0.2317 0.931
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.04 0.1647 0.1992
Trichomonas vaginalis CAMK family protein kinase 0.0532 0.2317 0.931
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0327 0.1272 0.1272
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0112 0.0177 0.0177
Loa Loa (eye worm) hypothetical protein 0.0157 0.0408 0.0442
Echinococcus multilocularis CDC7 cell division cycle 7 0.0109 0.0165 0.02
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0302 0.1146 1
Schistosoma mansoni serine/threonine protein kinase 0.047 0.2003 0.4223
Schistosoma mansoni tyrosine kinase 0.0477 0.2036 0.4293
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0159 0.0419 0.0507
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0328 0.128 0.1547
Entamoeba histolytica protein kinase, putative 0.0232 0.0792 0.3188
Brugia malayi map kinase activated protein kinase protein 2 0.0782 0.3593 0.3891
Schistosoma mansoni serine/threonine protein kinase 0.0642 0.2882 0.6076
Echinococcus granulosus serine:threonine protein kinase 0.0216 0.0708 0.0708
Echinococcus granulosus titin 0.0106 0.0148 0.0148
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0143 0.0339 0.0367
Echinococcus granulosus c-Jun N-terminal kinases 0.0519 0.2255 0.2255
Brugia malayi Protein kinase domain containing protein 0.1889 0.9235 1
Schistosoma mansoni serine/threonine protein kinase 0.0128 0.0263 0.0554
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0132 0.028 0.0338
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0078 0.0005 0.0006
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0328 0.128 0.1547
Brugia malayi protein-tyrosine kinase 0.0272 0.0995 0.1077
Echinococcus granulosus protein kinase 0.0173 0.0491 0.0491
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0167 0.0457 0.0495
Trichomonas vaginalis STE family protein kinase 0.0159 0.0419 0.1508
Brugia malayi putative serine/threonine kinase SADA gamma 0.0132 0.028 0.0303
Trichomonas vaginalis CAMK family protein kinase 0.0132 0.028 0.0934
Loa Loa (eye worm) hypothetical protein 0.024 0.0834 0.0903
Brugia malayi Protein kinase domain containing protein 0.0315 0.1213 0.1313
Echinococcus multilocularis mitogen activated protein kinase 11 0.0307 0.1172 0.1417
Echinococcus multilocularis N chimaerin 0.0155 0.0396 0.0479
Loa Loa (eye worm) TK/FER protein kinase 0.046 0.1953 0.2115
Loa Loa (eye worm) hypothetical protein 0.0078 0.0005 0.0005
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0459 0.1949 0.2357
Echinococcus multilocularis casein kinase I delta 0.0167 0.0457 0.0553
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0159 0.0419 0.0507
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0173 0.0491 0.0594
Echinococcus multilocularis tyrosine protein kinase HCK 0.0194 0.0598 0.0723
Echinococcus granulosus SH2 domain containing adapter protein F 0.0078 0.0005 0.0005
Schistosoma mansoni tyrosine kinase 0.0657 0.2956 0.6233
Echinococcus multilocularis Immunoglobulin 0.0149 0.0367 0.0444
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0124 0.024 0.0647
Schistosoma mansoni serine/threonine protein kinase 0.0327 0.1272 0.2682
Echinococcus multilocularis activin receptor type 0.0128 0.0259 0.0313
Schistosoma mansoni tensin 0.0078 0.0005 0.001
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0391 0.16 0.1935
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0128 0.0259 0.0732
Brugia malayi Homeodomain interacting protein kinase protein 1 0.0223 0.0746 0.0808
Loa Loa (eye worm) hypothetical protein 0.018 0.0528 0.0572
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0128 0.0259 0.1073
Echinococcus multilocularis mitogen activated protein kinase 14 0.0307 0.1172 0.1417
Trichomonas vaginalis CAMK family protein kinase 0.0132 0.028 0.0934
Schistosoma mansoni protein kinase 0.0188 0.0564 0.119
Echinococcus multilocularis 0.0287 0.1069 0.1293
Echinococcus multilocularis roundabout 2 0.0087 0.0053 0.0064
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0245 0.0858 0.181
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0381 0.1548 0.1548
Entamoeba histolytica protein kinase domain containing protein 0.0245 0.0858 0.3455
Brugia malayi Sex muscle abnormal protein 5 0.0134 0.029 0.0314
Onchocerca volvulus 0.0097 0.0105 0.0234
Loa Loa (eye worm) TK protein kinase 0.0318 0.1229 0.1331
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0174 0.0494 0.1543
Echinococcus granulosus serine:threonine protein kinase N2 0.0431 0.1804 0.1804
Loa Loa (eye worm) TK protein kinase 0.0512 0.2219 0.2403
Brugia malayi Protein kinase domain containing protein 0.0213 0.0696 0.0753
Loa Loa (eye worm) hypothetical protein 0.0124 0.024 0.0259
Loa Loa (eye worm) hypothetical protein 0.0078 0.0005 0.0005
Brugia malayi probable protein kinase 0.0297 0.1123 0.1216
Echinococcus multilocularis tyrosine protein kinase 0.0318 0.1229 0.1486
Trichomonas vaginalis CAMK family protein kinase 0.0132 0.028 0.0934
Echinococcus granulosus serine:threonine protein kinase 0.0216 0.0708 0.0708
Plasmodium vivax calcium-dependent protein kinase, putative 0.0143 0.0339 0.2296
Brugia malayi Protein kinase domain containing protein 0.0154 0.0391 0.0423
Onchocerca volvulus 0.0642 0.2882 0.672
Entamoeba histolytica casein kinase, putative 0.0188 0.0564 0.2271
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0278 0.1025 0.1025
Trichomonas vaginalis CAMK family protein kinase 0.0132 0.028 0.0934
Leishmania major protein kinase, putative 0.0143 0.0339 0.0951
Echinococcus multilocularis hypothetical protein 0.0165 0.0448 0.0542
Trypanosoma cruzi Protein kinase B 0.0316 0.1221 0.5064
Echinococcus multilocularis tyrosine protein kinase Blk 0.0272 0.0995 0.1203
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0327 0.1272 0.1538
Echinococcus granulosus epidermal growth factor receptor 0.1008 0.4743 0.4743
Loa Loa (eye worm) protein kinase domain-containing protein 0.0234 0.0801 0.0867
Echinococcus multilocularis casein kinase I alpha 0.0167 0.0457 0.0553
Loa Loa (eye worm) TK/ROR protein kinase 0.0112 0.0177 0.0192
Brugia malayi Doublecortin family protein 0.0171 0.048 0.0519
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.04 0.1647 0.1647
Schistosoma mansoni suppressor of cytokine signaling 0.0078 0.0005 0.001
Echinococcus multilocularis SHC transforming protein 3 0.0078 0.0005 0.0006
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0155 0.0396 0.0836
Trichomonas vaginalis AGC family protein kinase 0.0564 0.2485 1
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0078 0.0005 0.0006
Schistosoma mansoni nephrin 0.0203 0.0643 0.1355
Schistosoma mansoni vav2 0.0169 0.0471 0.0992
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0536 0.2341 0.2535
Schistosoma mansoni protein kinase 0.0297 0.1123 0.2367
Echinococcus granulosus nervana 2 0.025 0.0882 0.0882
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0232 0.0792 0.3135
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0174 0.0494 0.1793
Entamoeba histolytica casein kinase 1, putative 0.0167 0.0457 0.1841
Schistosoma mansoni tyrosine kinase 0.0657 0.2956 0.6233
Entamoeba histolytica p21-activated kinase 0.0174 0.0493 0.1986
Schistosoma mansoni serine/threonine protein kinase 0.0225 0.0757 0.1596
Plasmodium vivax casein kinase 1, putative 0.0167 0.0457 0.3428
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0278 0.1025 0.1239
Schistosoma mansoni serine/threonine protein kinase 0.0173 0.0491 0.1035
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0173 0.0491 0.1779
Schistosoma mansoni serine/threonine protein kinase 0.0279 0.1032 0.2175
Toxoplasma gondii histone kinase SNF1, putative 0.0132 0.028 0.116
Trichomonas vaginalis CMGC family protein kinase 0.0159 0.0419 0.1506
Echinococcus granulosus c src tyrosine kinase 0.0209 0.0676 0.0676
Trichomonas vaginalis CAMK family protein kinase 0.0216 0.0708 0.2698
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0225 0.0757 0.0757
Loa Loa (eye worm) TK/FER protein kinase 0.0154 0.0391 0.0423
Schistosoma mansoni serine/threonine protein kinase 0.0132 0.028 0.0589
Trypanosoma brucei cdc2-related kinase 3 0.0225 0.0757 0.2659
Brugia malayi Protein kinase domain containing protein 0.0216 0.0708 0.0767
Brugia malayi Temporarily assigned gene name protein 59 0.0261 0.0937 0.1015
Echinococcus multilocularis tensin 0.0078 0.0005 0.0006
Loa Loa (eye worm) TK/FER protein kinase 0.0154 0.0391 0.0423
Trichomonas vaginalis CAMK family protein kinase 0.0532 0.2317 0.931
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0245 0.0858 0.3328
Giardia lamblia Kinase, CMGC CLK 0.0174 0.0494 0.1662
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0173 0.0491 0.0532
Brugia malayi Protein kinase domain containing protein 0.0174 0.0494 0.0535
Schistosoma mansoni serine/threonine protein kinase 0.0173 0.0491 0.1035
Trichomonas vaginalis CK1 family protein kinase 0.0167 0.0457 0.1665
Schistosoma mansoni serine/threonine protein kinase 0.0351 0.1395 0.294
Plasmodium vivax serine/threonine protein kinase, putative 0.0103 0.0131 0.0314
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0782 0.3593 0.4344
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0176 0.0504 0.0504
Schistosoma mansoni serine/threonine protein kinase 0.0381 0.1548 0.3264
Echinococcus granulosus tyrosine protein kinase 0.0318 0.1229 0.1229
Giardia lamblia Kinase, CMGC DYRK 0.0159 0.0419 0.1316
Trichomonas vaginalis AGC family protein kinase 0.026 0.0935 0.3631
Entamoeba histolytica serine/threonine protein kinase, putative 0.0132 0.028 0.1125
Echinococcus multilocularis maternal embryonic leucine zipper kinase 0.0135 0.0296 0.0357
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0128 0.0263 0.0263
Loa Loa (eye worm) TK/ABL protein kinase 0.0154 0.0391 0.0423
Echinococcus multilocularis calcium activated potassium channel 0.0217 0.0712 0.0861
Schistosoma mansoni serine/threonine protein kinase 0.0184 0.0548 0.1155
Echinococcus granulosus Protein kinase C brain isozyme 0.0459 0.1949 0.1949
Echinococcus granulosus RNA directed DNA polymerase 0.008 0.0017 0.0017
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0356 0.142 0.1538
Loa Loa (eye worm) hypothetical protein 0.0079 0.0013 0.0014
Brugia malayi casein kinase 1, delta 0.0167 0.0457 0.0495
Trichomonas vaginalis AGC family protein kinase 0.0321 0.1242 0.489
Trichomonas vaginalis CAMK family protein kinase 0.0132 0.028 0.0934
Plasmodium falciparum calcium-dependent protein kinase 1 0.0143 0.0339 0.2131
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.0159 0.0419 0.0453
Brugia malayi Variant SH3 domain containing protein 0.0095 0.0092 0.01
Giardia lamblia Kinase, CMGC CDK 0.0225 0.0757 0.2863
Echinococcus granulosus casein kinase i 0.0167 0.0457 0.0457
Trypanosoma brucei aurora B kinase 0.0279 0.1032 0.3827
Brugia malayi Pleckstrin Homology Domain 0.0091 0.0074 0.0081
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.0096 0.0202
Plasmodium falciparum calcium-dependent protein kinase 3 0.0143 0.0339 0.2131
Schistosoma mansoni serine/threonine protein kinase 0.0519 0.2255 0.4754
Echinococcus granulosus serine:threonine protein kinase TAO1 0.0243 0.0847 0.0847
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0143 0.0339 0.0409
Echinococcus multilocularis death associated protein kinase 1 0.17 0.8271 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0143 0.0339 0.0339
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0149 0.0367 0.0444
Echinococcus multilocularis tyrosine kinase 0.0154 0.0391 0.0472
Loa Loa (eye worm) hypothetical protein 0.0227 0.0764 0.0828
Trypanosoma brucei protein kinase, putative 0.0154 0.0396 0.1125
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0139 0.0317 0.0343
Loa Loa (eye worm) AGC/PKN protein kinase 0.0431 0.1804 0.1954
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0159 0.0419 0.1453
Schistosoma mansoni protein kinase 0.048 0.2054 0.4331
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0209 0.0676 0.1425
Brugia malayi Protein kinase domain containing protein 0.0184 0.0548 0.0593
Onchocerca volvulus 0.0591 0.2618 0.6103
Giardia lamblia Kinase, PLK 0.0532 0.2317 1
Loa Loa (eye worm) AUR protein kinase 0.0279 0.1032 0.1117
Loa Loa (eye worm) hypothetical protein 0.0216 0.0708 0.0767
Echinococcus multilocularis mitogen activated protein kinase 0.0154 0.0396 0.0478
Brugia malayi Protein kinase domain containing protein 0.0369 0.1489 0.1613
Echinococcus multilocularis mitogen activated protein kinase 3 0.0154 0.0396 0.0478
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0173 0.0491 0.0491
Trichomonas vaginalis AGC family protein kinase 0.0173 0.0491 0.1804
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0155 0.0396 0.0429
Schistosoma mansoni serine/threonine protein kinase 0.0391 0.1601 0.3375
Brugia malayi protein unc-22 0.0106 0.0148 0.016
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0159 0.0419 0.0419
Schistosoma mansoni protein kinase 0.0213 0.0696 0.1467
Schistosoma mansoni ephrin receptor 0.0205 0.0654 0.1378
Loa Loa (eye worm) hypothetical protein 0.021 0.068 0.0737
Echinococcus multilocularis casein kinase I gamma 0.0234 0.0801 0.0968
Echinococcus granulosus protein kinase shaggy 0.0245 0.0858 0.0858
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0351 0.1395 0.1395
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0302 0.1146 0.1146
Schistosoma mansoni protein kinase 0.0115 0.0196 0.0412
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0225 0.0757 0.2863
Schistosoma mansoni serine/threonine protein kinase 0.0431 0.1804 0.3804
Echinococcus multilocularis growth factor receptor bound protein 2 0.0134 0.029 0.035
Loa Loa (eye worm) CAMK/PHK protein kinase 0.0184 0.0548 0.0593
Brugia malayi Immunoglobulin I-set domain containing protein 0.0106 0.0148 0.016
Brugia malayi Protein kinase domain containing protein 0.0391 0.1601 0.1734
Brugia malayi MAP kinase sur-1 0.0154 0.0396 0.0428
Echinococcus multilocularis unc 13 (munc13) 0.0079 0.0013 0.0016
Echinococcus granulosus tyrosine protein kinase Fps85D 0.046 0.1953 0.1953
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.0472 0.2013 0.218
Schistosoma mansoni serine/threonine protein kinase 0.0223 0.0746 0.1574
Schistosoma mansoni serine/threonine protein kinase 0.0155 0.0396 0.0835
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0143 0.0339 0.0367
Loa Loa (eye worm) hypothetical protein 0.0218 0.0719 0.0778
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0143 0.0339 0.1405
Plasmodium falciparum NIMA related kinase 1 0.026 0.0935 0.7944
Trichomonas vaginalis AGC family protein kinase 0.015 0.0372 0.1316
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0078 0.0005 0.0006
Loa Loa (eye worm) TK/ALK protein kinase 0.0315 0.1212 0.1313
Echinococcus granulosus fibroblast growth factor receptor 4 0.0477 0.2036 0.2036
Echinococcus granulosus cyclin dependent kinase 5 0.0225 0.0757 0.0757
Brugia malayi serine/threonine-protein kinase plk-2 0.0532 0.2317 0.2509
Echinococcus multilocularis STE20 serine:threonine protein kinase 0.0518 0.2249 0.2719
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0614 0.2736 0.2736
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0173 0.0491 0.1779
Echinococcus granulosus tyrosine kinase 0.0272 0.0995 0.0995
Echinococcus multilocularis nervana 2 0.025 0.0882 0.1066
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0134 0.029 0.0314
Brugia malayi Protein kinase domain containing protein 0.0232 0.0792 0.0858
Schistosoma mansoni vam6/vps39 related 0.0124 0.024 0.0505
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0143 0.0339 0.1405
Leishmania major protein kinase, putative 0.0128 0.0259 0.0584
Echinococcus multilocularis myosin iiia 0.0156 0.0405 0.049
Loa Loa (eye worm) TK protein kinase 0.0194 0.0598 0.0648
Toxoplasma gondii CMGC kinase, CK2 family 0.0188 0.0564 0.2341
Echinococcus granulosus cyclin dependent kinase 1 0.0225 0.0757 0.0757
Schistosoma mansoni cell adhesion molecule 0.0087 0.0053 0.0111
Trichomonas vaginalis CAMK family protein kinase 0.0132 0.028 0.0934
Echinococcus multilocularis 0.0078 0.0005 0.0006
Echinococcus multilocularis serine:threonine protein kinase N2 0.0431 0.1804 0.2181
Loa Loa (eye worm) hypothetical protein 0.0149 0.037 0.0401
Echinococcus granulosus serine:threonine kinase SAD 1 0.0132 0.028 0.028
Echinococcus granulosus neuroglian 0.0185 0.055 0.055
Loa Loa (eye worm) camk/dcamkl protein kinase 0.0171 0.048 0.0519
Echinococcus multilocularis casein kinase I delta 0.0167 0.0457 0.0553
Entamoeba histolytica protein kinase, putative 0.0128 0.0263 0.1058
Trichomonas vaginalis CAMK family protein kinase 0.0132 0.028 0.0934
Brugia malayi Protein kinase domain containing protein 0.0109 0.0165 0.0179
Plasmodium falciparum serine/threonine protein kinase KIN 0.0132 0.028 0.1554
Trichomonas vaginalis AGC family protein kinase 0.015 0.0372 0.1316
Echinococcus granulosus N chimaerin 0.0155 0.0396 0.0396
Schistosoma mansoni serine/threonine protein kinase 0.0159 0.0419 0.0882
Echinococcus granulosus neuroglian 0.0087 0.0053 0.0053
Trichomonas vaginalis CMGC family protein kinase 0.0109 0.0165 0.0464
Echinococcus multilocularis cyclin dependent kinase 0.0225 0.0757 0.0915
Brugia malayi intracellular kinase 0.0245 0.0858 0.093
Echinococcus granulosus SH2 motif 0.0078 0.0005 0.0005
Echinococcus multilocularis mitogen activated protein kinase 11 0.0307 0.1172 0.1417
Schistosoma mansoni protein kinase 0.0279 0.1032 0.2175
Echinococcus granulosus serine threonine protein kinase nrc 0.0302 0.1146 0.1146
Loa Loa (eye worm) hypothetical protein 0.0318 0.123 0.1332
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0532 0.2317 0.2509
Giardia lamblia Kinase, CDC7 0.0109 0.0165 0.0157
Echinococcus multilocularis nervana 2 0.025 0.0882 0.1066
Entamoeba histolytica SH2 domain containing protein 0.0078 0.0005 0.0019
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0328 0.128 0.1547
Loa Loa (eye worm) TK/FER protein kinase 0.0154 0.0391 0.0423
Schistosoma mansoni serine/threonine protein kinase 0.0143 0.0339 0.0714
Echinococcus multilocularis PAK box P21 Rho binding 0.0115 0.0196 0.0237
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0657 0.2956 0.2956
Loa Loa (eye worm) thyroid receptor interactor 0.0133 0.0284 0.0308
Brugia malayi protein kinase C II. 0.0379 0.1541 0.1669
Brugia malayi serine/threonine-protein kinase 6 0.0279 0.1032 0.1117
Plasmodium vivax tyrosine kinase-like protein, putative 0.01 0.012 0.0211
Echinococcus granulosus homeodomain interacting protein kinase 3 0.0223 0.0746 0.0746
Echinococcus multilocularis RNA directed DNA polymerase 0.008 0.0017 0.002
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0307 0.1172 0.4424
Entamoeba histolytica protein kinase, putative 0.0103 0.0131 0.0526
Schistosoma mansoni hypothetical protein 0.0124 0.024 0.0505
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0081 0.0019 0.0021
Trichomonas vaginalis CMGC family protein kinase 0.0188 0.0564 0.2105
Brugia malayi Protein kinase domain 0.0159 0.0419 0.0454
Loa Loa (eye worm) AGC/PKA protein kinase 0.0173 0.0491 0.0532
Loa Loa (eye worm) hypothetical protein 0.058 0.2566 0.2778
Loa Loa (eye worm) hypothetical protein 0.008 0.0015 0.0017
Trichomonas vaginalis CMGC family protein kinase 0.0109 0.0165 0.0464
Trichomonas vaginalis AGC family protein kinase 0.0335 0.1316 0.5196
Entamoeba histolytica serine/threonine protein kinase, putative 0.0532 0.2317 0.9325
Brugia malayi Immunoglobulin I-set domain containing protein 0.0081 0.0019 0.0021
Echinococcus granulosus expressed conserved protein 0.0078 0.0005 0.0005
Echinococcus granulosus tyrosine protein kinase Fyn 0.0328 0.128 0.128
Schistosoma mansoni serine/threonine protein kinase 0.03 0.1136 0.2396
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0155 0.0396 0.0479
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0121 0.0227 0.0227
Schistosoma mansoni serine/threonine protein kinase 0.0103 0.0131 0.0276
Schistosoma mansoni cell adhesion molecule 0.0087 0.0053 0.0111
Loa Loa (eye worm) STAT protein 0.0078 0.0005 0.0005
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0121 0.0227 0.0274
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0272 0.0995 0.0995
Toxoplasma gondii cell-cycle-associated protein kinase SRPK, putative 0.0103 0.0131 0.0543
Brugia malayi Tyrosine-protein kinase abl-1 0.0209 0.0676 0.0732
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0155 0.0396 0.0396
Loa Loa (eye worm) hypothetical protein 0.0078 0.0005 0.0005
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0337 0.1324 0.1433
Trichomonas vaginalis CAMK family protein kinase 0.0241 0.0835 0.3217
Echinococcus multilocularis serine:threonine protein kinase 38 0.03 0.1136 0.1374
Schistosoma mansoni serine/threonine protein kinase 0.0379 0.1541 0.3249
Loa Loa (eye worm) hypothetical protein 0.0091 0.0074 0.0081
Schistosoma mansoni nephrin 0.0087 0.0053 0.0111
Echinococcus multilocularis 0.0122 0.023 0.0278
Schistosoma mansoni serine/threonine protein kinase 0.013 0.0269 0.0567
Trypanosoma brucei polo-like protein kinase 0.0532 0.2317 0.9287
Brugia malayi Protein kinase domain containing protein 0.0536 0.2341 0.2535
Schistosoma mansoni serine/threonine protein kinase 0.0173 0.0491 0.1035
Entamoeba histolytica protein kinase, putative 0.0146 0.0352 0.1416
Schistosoma mansoni serine/threonine protein kinase 0.0132 0.028 0.0589
Schistosoma mansoni serine/threonine protein kinase 0.0243 0.0847 0.1786
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0134 0.029 0.0314
Brugia malayi Variant SH3 domain containing protein 0.0134 0.029 0.0314
Echinococcus granulosus dual specificity 0.0159 0.0419 0.0419
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0087 0.0053 0.0064
Echinococcus granulosus tyrosine protein kinase Lyn 0.038 0.1544 0.1544
Plasmodium falciparum calcium-dependent protein kinase 4 0.0143 0.0339 0.2131
Entamoeba histolytica protein kinase, putative 0.0143 0.0339 0.1363
Schistosoma mansoni serine/threonine protein kinase 0.0132 0.028 0.0589
Echinococcus granulosus dual specificity 0.0232 0.0792 0.0792
Brugia malayi serine/threonine-protein kinase PAK 7 0.0454 0.1923 0.2083
Loa Loa (eye worm) hypothetical protein 0.0245 0.0858 0.093
Echinococcus multilocularis serine:threonine protein kinase 0.0216 0.0708 0.0857
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0078 0.0005 0.0005
Brugia malayi Protein kinase domain containing protein 0.0081 0.0021 0.0023
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0198 0.0619 0.0748
Echinococcus granulosus activin receptor type 0.0128 0.0259 0.0259
Trypanosoma brucei casein kinase I, isoform 2 0.0167 0.0457 0.1387
Echinococcus multilocularis myotubularin protein 13 0.0091 0.0074 0.009
Entamoeba histolytica protein kinase domain containing protein 0.0232 0.0792 0.3188
Trichomonas vaginalis CAMK family protein kinase 0.0132 0.028 0.0934
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0279 0.1032 0.1032
Echinococcus granulosus tyrosine protein kinase Fyn 0.0328 0.128 0.128
Trypanosoma brucei rac serine-threonine kinase, putative 0.0564 0.2485 1
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0536 0.2341 0.2535
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.008 0.0017 0.002
Loa Loa (eye worm) hypothetical protein 0.0167 0.046 0.0498
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0536 0.2341 0.2831
Giardia lamblia Kinase, CMGC MAPK 0.0154 0.0396 0.1211
Entamoeba histolytica PH domain containing protein kinase, putative 0.0188 0.0565 0.2276
Echinococcus granulosus suppressor of cytokine signaling 7 0.0078 0.0005 0.0005
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.047 0.2003 0.2169
Plasmodium falciparum casein kinase 2, alpha subunit 0.0188 0.0564 0.4328
Trichomonas vaginalis STE family protein kinase 0.0159 0.0419 0.1508
Trypanosoma cruzi casein kinase, putative 0.0167 0.0457 0.1627
Trichomonas vaginalis CMGC family protein kinase 0.0154 0.0396 0.1411
Giardia lamblia Kinase, CK1 Casein kinase 0.0167 0.0457 0.1494
Trichomonas vaginalis AGC family protein kinase 0.0279 0.1032 0.4026
Schistosoma mansoni atypical protein kinase C 0.0557 0.2445 0.5154
Loa Loa (eye worm) SH2 domain-containing protein 0.0078 0.0005 0.0005
Schistosoma mansoni serine/threonine-protein kinase 0.0316 0.1221 0.2574
Loa Loa (eye worm) hypothetical protein 0.0281 0.1038 0.1124
Trichomonas vaginalis AGC family protein kinase 0.0564 0.2485 1
Trypanosoma cruzi casein kinase II, putative 0.0188 0.0564 0.2109
Trichomonas vaginalis CAMK family protein kinase 0.0132 0.028 0.0934
Echinococcus granulosus tyrosine protein kinase Fyn 0.0328 0.128 0.128
Plasmodium falciparum protein kinase, putative 0.0128 0.0259 0.135
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0132 0.028 0.0827
Brugia malayi Protein kinase domain containing protein 0.04 0.1647 0.1784
Echinococcus granulosus protein kinase C gamma type 0.0383 0.1558 0.1558
Trichomonas vaginalis CAMK family protein kinase 0.0532 0.2317 0.931
Trichomonas vaginalis AGC family protein kinase 0.0564 0.2485 1
Echinococcus granulosus protein tyrosine kinase 0.0587 0.2601 0.2601
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0536 0.2341 0.5458
Loa Loa (eye worm) hypothetical protein 0.0079 0.0012 0.0013
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0328 0.128 0.128
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.03 0.1136 0.1374
Loa Loa (eye worm) hypothetical protein 0.0107 0.0155 0.0168
Echinococcus multilocularis rho associated protein kinase 0.0642 0.2882 0.3484
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0232 0.0792 0.281
Brugia malayi cell division control protein 2 homolog 0.0225 0.0757 0.0819
Loa Loa (eye worm) TK/EGFR protein kinase 0.1008 0.4743 0.5136
Plasmodium vivax unspecified product 0.0188 0.0564 0.4448
Loa Loa (eye worm) hypothetical protein 0.0124 0.024 0.0259
Loa Loa (eye worm) TK/FER protein kinase 0.0154 0.0391 0.0423
Echinococcus multilocularis 0.0173 0.0491 0.0594
Loa Loa (eye worm) CDC7 protein kinase 0.0109 0.0165 0.0179
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0078 0.0005 0.001
Echinococcus granulosus casein kinase I alpha 0.0167 0.0457 0.0457
Schistosoma mansoni serine/threonine protein kinase 0.0381 0.1548 0.3264
Brugia malayi Protein kinase domain containing protein 0.0318 0.1229 0.1331
Entamoeba histolytica PH domain containing protein kinase, putative 0.0188 0.0565 0.2276
Schistosoma mansoni tyrosine kinase 0.071 0.3224 0.6798
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0309 0.1181 0.1279
Entamoeba histolytica protein kinase, putative 0.0564 0.2485 1
Plasmodium vivax serine/threonine kinase-1, putative 0.0174 0.0494 0.3778
Echinococcus multilocularis phosphorylase kinase gamma subunit 0.0184 0.0548 0.0662
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.047 0.2003 0.2421
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0079 0.0013 0.0013
Trichomonas vaginalis AGC family protein kinase 0.03 0.1136 0.4458
Loa Loa (eye worm) hypothetical protein 0.0092 0.0079 0.0086
Onchocerca volvulus 0.0154 0.0391 0.0901
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0536 0.2341 0.2535
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0391 0.1601 0.1734
Echinococcus granulosus expressed protein 0.0103 0.0131 0.0131
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0167 0.0457 0.0495
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0174 0.0494 0.205
Brugia malayi serine/threonine protein kinase 6 0.0279 0.1032 0.1117
Onchocerca volvulus 0.0167 0.0457 0.1057
Loa Loa (eye worm) hypothetical protein 0.0227 0.0764 0.0828
Schistosoma mansoni tyrosine kinase 0.0369 0.149 0.3142
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0124 0.024 0.0505
Echinococcus granulosus tyrosine protein kinase Src64B 0.0328 0.128 0.128
Onchocerca volvulus 0.0106 0.0148 0.0335
Brugia malayi Stress-activated protein kinase jnk-1 0.0519 0.2255 0.2442
Loa Loa (eye worm) CAMK/CAMKL/PASK protein kinase 0.0097 0.0105 0.0114
Giardia lamblia Kinase, CMGC CDK 0.0225 0.0757 0.2863
Echinococcus multilocularis calcium dependent protein kinase 0.0091 0.0074 0.009
Entamoeba histolytica cell division protein kinase 2, putative 0.0225 0.0757 0.3046
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0128 0.0263 0.0263
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0272 0.0995 0.1203
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0173 0.0491 0.3615
Echinococcus granulosus dual specificity protein kinase clk2 0.0174 0.0494 0.0494
Echinococcus multilocularis serine:threonine protein kinase N2 0.0131 0.0276 0.0334
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0316 0.1221 0.5064
Echinococcus granulosus casein kinase I gamma 0.0234 0.0801 0.0801
Brugia malayi p21/Cdc42/Rac1-activated kinase 0.0096 0.0096 0.0104
Giardia lamblia Kinase, AGC AKT 0.0222 0.0739 0.2782
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0096 0.0096 0.0104
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0659 0.2964 0.321
Brugia malayi Variant SH3 domain containing protein 0.0155 0.0396 0.0429
Echinococcus granulosus maternal embryonic leucine zipper kinase 0.0135 0.0296 0.0296
Echinococcus multilocularis raf serine:threonine protein kinase 0.0153 0.0386 0.0467
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.0155 0.0422
Schistosoma mansoni ste20-related kinase 0.04 0.1646 0.347
Entamoeba histolytica protein kinase, putative 0.0128 0.0263 0.1058
Plasmodium falciparum calcium-dependent protein kinase 2 0.0143 0.0339 0.2131
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0307 0.1172 0.4763
Brugia malayi casein kinase I 0.0167 0.0457 0.0495
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0216 0.0708 0.0767
Schistosoma mansoni rap gtpase-activating protein 0.0124 0.024 0.0505
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.0223 0.0746 0.0808
Trypanosoma cruzi casein kinase, putative 0.0167 0.0457 0.1627
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0154 0.0396 0.1349
Schistosoma mansoni tyrosine kinase 0.0581 0.257 0.5419
Trichomonas vaginalis CAMK family protein kinase 0.0143 0.0339 0.1178
Echinococcus granulosus casein kinase I delta 0.0167 0.0457 0.0457
Entamoeba histolytica protein kinase, putative 0.015 0.0372 0.1498
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0225 0.0757 0.0819
Echinococcus granulosus casein kinase I delta 0.0167 0.0457 0.0457
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0143 0.0339 0.0339
Schistosoma mansoni serine/threonine protein kinase 0.0234 0.0801 0.1689
Schistosoma mansoni serine/threonine protein kinase 0.0532 0.2317 0.4885
Schistosoma mansoni protein kinase C 0.0079 0.0013 0.0027
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative 0.0132 0.028 0.068
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0155 0.0396 0.0479
Brugia malayi p70 ribosomal S6 kinase beta 0.055 0.241 0.261
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0149 0.0367 0.0774
Echinococcus granulosus epidermal growth factor receptor 0.0657 0.2956 0.2956
Onchocerca volvulus 0.0124 0.024 0.0548
Entamoeba histolytica cell division protein kinase 2, putative 0.0225 0.0757 0.3046
Echinococcus granulosus insulin receptor 0.071 0.3224 0.3224
Schistosoma mansoni serine/threonine protein kinase 0.0782 0.3593 0.7576
Onchocerca volvulus 0.0154 0.0391 0.0901
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0328 0.128 0.1547
Schistosoma mansoni protein kinase 0.048 0.2054 0.4331
Loa Loa (eye worm) hypothetical protein 0.0078 0.0005 0.0005
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0279 0.1032 0.4152
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0078 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0466 0.1985 0.2149
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0307 0.1172 0.1269
Loa Loa (eye worm) CMGC/SRPK protein kinase 0.0103 0.0131 0.0142
Entamoeba histolytica protein kinase, putative 0.0279 0.1032 0.4152
Echinococcus multilocularis NCK adaptor protein 0.0136 0.03 0.0363
Echinococcus granulosus ephrin type A receptor 4 A 0.0205 0.0654 0.0654
Echinococcus multilocularis cyclin dependent kinase 1 0.0225 0.0757 0.0915
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0188 0.0564 0.0611
Schistosoma mansoni protein kinase 0.04 0.1647 0.3473
Brugia malayi Protein kinase domain containing protein 0.015 0.0372 0.0403
Schistosoma mansoni serine/threonine protein kinase 0.0217 0.0712 0.1501
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0302 0.1146 0.1386
Schistosoma mansoni serine/threonine protein kinase 0.0174 0.0494 0.1042
Brugia malayi Protein kinase domain containing protein 0.0625 0.2793 0.3024
Echinococcus granulosus mitogen activated protein kinase 11 0.0307 0.1172 0.1172
Schistosoma mansoni serine/threonine protein kinase 0.0153 0.0386 0.0814
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0225 0.0757 0.314
Schistosoma mansoni tensin-related 0.0078 0.0005 0.001
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0112 0.0177 0.0214
Trichomonas vaginalis STE family protein kinase 0.0115 0.0196 0.059
Echinococcus granulosus mitogen activated protein kinase 3 0.0154 0.0396 0.0396
Echinococcus multilocularis twitchin 0.0088 0.0055 0.0067
Echinococcus multilocularis serine:threonine protein kinase 3 0.0504 0.2178 0.2634
Trichomonas vaginalis AGC family protein kinase 0.015 0.0372 0.1316
Onchocerca volvulus 0.0807 0.3718 0.8672
Schistosoma mansoni shc transforming protein 0.0078 0.0005 0.001
Trichomonas vaginalis CMGC family protein kinase 0.0154 0.0396 0.1411
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0536 0.2341 0.2341
Echinococcus granulosus unc 13 munc13 0.0079 0.0013 0.0013
Echinococcus multilocularis protein kinase shaggy 0.0245 0.0858 0.1038
Onchocerca volvulus 0.0109 0.0165 0.0375
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0087 0.0053 0.0064
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0381 0.1548 0.1872
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0236 0.0813 0.3122
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.0243 0.0847 0.1024
Onchocerca volvulus 0.0281 0.1038 0.2413
Brugia malayi Variant SH3 domain containing protein 0.0134 0.029 0.0314
Entamoeba histolytica protein kinase, putative 0.0159 0.0419 0.1685
Brugia malayi STAT protein, DNA binding domain containing protein 0.0078 0.0005 0.0005
Schistosoma mansoni serine/threonine protein kinase 0.0155 0.0396 0.0835
Brugia malayi Protein kinase domain containing protein 0.0234 0.0801 0.0867
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0245 0.0858 0.0858
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0532 0.2317 1
Schistosoma mansoni nck2/grb4 0.0134 0.029 0.0611
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0232 0.0792 0.3025
Loa Loa (eye worm) hypothetical protein 0.0129 0.0268 0.029
Echinococcus granulosus tyrosine protein kinase Src42A 0.0328 0.128 0.128
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0154 0.0396 0.1211
Leishmania major protein kinase, putative 0.0174 0.0494 0.1662
Schistosoma mansoni protein kinase 0.0128 0.0259 0.0545
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.015 0.0372 0.0403
Schistosoma mansoni signal transduction protein lnk-related 0.0078 0.0005 0.001
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0173 0.0491 0.0491
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0245 0.0858 0.093
Echinococcus granulosus cGMP dependent protein kinase 1 0.0155 0.0396 0.0396
Schistosoma mansoni protein kinase 0.0159 0.0419 0.0883
Onchocerca volvulus 0.0112 0.0179 0.0406
Giardia lamblia Kinase, CMGC CK2 0.0188 0.0564 0.1983
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0307 0.1172 0.4845
Echinococcus granulosus roundabout 2 0.0236 0.0812 0.0812
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0532 0.2317 0.2801
Schistosoma mansoni serine/threonine protein kinase 0.0276 0.1016 0.2142
Echinococcus granulosus hypothetical protein 0.0122 0.023 0.023
Entamoeba histolytica protein kinase domain containing protein 0.0188 0.0564 0.2271
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0351 0.1395 0.1686
Trichomonas vaginalis CMGC family protein kinase 0.0245 0.0858 0.3314
Loa Loa (eye worm) IKK protein kinase 0.0519 0.2255 0.2442
Schistosoma mansoni serine/threonine protein kinase 0.0232 0.0792 0.167
Toxoplasma gondii AGC kinase 0.055 0.241 1
Entamoeba histolytica protein kinase, putative 0.0232 0.0792 0.3188
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0337 0.1324 0.1433
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0614 0.2736 0.3309
Brugia malayi SH2 domain containing protein 0.046 0.1953 0.2115
Trichomonas vaginalis AGC family protein kinase 0.0279 0.1032 0.4026
Schistosoma mansoni cell adhesion molecule 0.02 0.0629 0.1326
Loa Loa (eye worm) hypothetical protein 0.0143 0.0339 0.0367
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0096 0.0096 0.0104
Schistosoma mansoni serine/threonine protein kinase 0.0351 0.1395 0.294
Trichomonas vaginalis CMGC family protein kinase 0.0188 0.0564 0.2105
Echinococcus granulosus roundabout 2 0.0087 0.0053 0.0053
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0128 0.0263 0.0318
Schistosoma mansoni serine/threonine protein kinase 0.0217 0.0712 0.1501
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.048 0.2054 0.2054
Brugia malayi Cam kinase protein 1 0.0143 0.0339 0.0367
Trichomonas vaginalis CMGC family protein kinase 0.0109 0.0165 0.0464
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0174 0.0494 0.1793
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0328 0.128 0.1547
Trypanosoma brucei Casein kinase II 0.0188 0.0564 0.1841
Entamoeba histolytica protein kinase domain containing protein 0.0082 0.0027 0.0109
Loa Loa (eye worm) hypothetical protein 0.0625 0.2793 0.3024
Loa Loa (eye worm) hypothetical protein 0.0357 0.1429 0.1548
Loa Loa (eye worm) hypothetical protein 0.0149 0.0367 0.0398
Onchocerca volvulus Serine\/threonine kinase homolog 0.0532 0.2317 0.54
Schistosoma mansoni serine/threonine protein kinase 0.0167 0.0457 0.0964
Echinococcus multilocularis expressed conserved protein 0.0155 0.0396 0.0479
Brugia malayi cyclin-dependent kinase 7 homolog 0.013 0.0269 0.0291
Loa Loa (eye worm) hypothetical protein 0.0078 0.0005 0.0005
Schistosoma mansoni protein kinase 0.0159 0.0419 0.0883
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0327 0.1272 0.1378
Giardia lamblia Kinase, AGC PKA 0.0302 0.1146 0.4645
Leishmania major protein kinase A catalytic subunit isoform 2 0.0173 0.0491 0.1648
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0245 0.0858 0.3561
Brugia malayi SH2 domain containing protein 0.0078 0.0005 0.0005
Echinococcus multilocularis titin 0.0106 0.0148 0.0179
Mycobacterium ulcerans hypothetical protein 0.0103 0.0132 0.5
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0159 0.0419 0.0419
Echinococcus multilocularis cyclin dependent kinase 7 0.013 0.0269 0.0325
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0173 0.0491 0.0594
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0079 0.0013 0.0016
Echinococcus granulosus cyclin dependent kinase 0.0225 0.0757 0.0757
Brugia malayi Casein kinase II, alpha chain 0.0188 0.0564 0.0611
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0173 0.0491 0.0594
Schistosoma mansoni serine/threonine protein kinase 0.0088 0.0055 0.0116
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.1889 0.9235 1
Brugia malayi Protein kinase domain containing protein 0.0293 0.1103 0.1195
Leishmania major casein kinase II, putative 0.0188 0.0564 0.1983
Schistosoma mansoni serine/threonine-protein kinase 0.0316 0.1221 0.2574
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0174 0.0494 0.1793
Loa Loa (eye worm) TK protein kinase 0.0382 0.1557 0.1686
Plasmodium falciparum protein kinase 5 0.0225 0.0757 0.6204
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0159 0.0419 0.0419
Brugia malayi Protein kinase c protein 2 0.0211 0.0686 0.0742
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0159 0.0419 0.1222
Schistosoma mansoni protein kinase 0.0442 0.186 0.3922
Loa Loa (eye worm) SH2 domain-containing protein 0.0078 0.0005 0.0005
Giardia lamblia Kinase, CAMK CAMKL 0.0132 0.028 0.068
Brugia malayi SH2 domain containing protein 0.0078 0.0005 0.0005
Brugia malayi Fes/CIP4 homology domain containing protein 0.0133 0.0284 0.0308
Echinococcus granulosus tyrosine protein kinase Blk 0.0272 0.0995 0.0995
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0173 0.0491 0.1779
Trichomonas vaginalis STE family protein kinase 0.0159 0.0419 0.1508
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0728 0.3317 0.3317
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0143 0.0339 0.2296
Echinococcus granulosus titin 0.0106 0.0148 0.0148
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0477 0.2036 0.2036
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.0159 0.0419 0.1737
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0128 0.0263 0.0318
Schistosoma mansoni tyrosine kinase 0.0139 0.0317 0.0669
Loa Loa (eye worm) TK protein kinase 0.0272 0.0995 0.1077
Brugia malayi Tensin 0.0078 0.0005 0.0005
Loa Loa (eye worm) STE/STE20/SLK protein kinase 0.0213 0.0696 0.0753
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0078 0.0005 0.0006
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0143 0.0339 0.2296
Echinococcus granulosus growth factor receptor bound protein 2 0.0136 0.03 0.03
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0128 0.0259 0.0732
Echinococcus multilocularis serine:threonine protein kinase N2 0.03 0.1136 0.1374
Brugia malayi Protein kinase domain containing protein 0.071 0.3224 0.3492
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0381 0.1548 0.1548
Loa Loa (eye worm) TK/FER protein kinase 0.0154 0.0391 0.0423
Entamoeba histolytica protein kinase, putative 0.03 0.1136 0.4574
Schistosoma mansoni serine/threonine protein kinase 0.0109 0.0165 0.0348
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0519 0.2255 0.2442
Brugia malayi Protein kinase domain containing protein 0.0225 0.0757 0.0819
Loa Loa (eye worm) SRC-1 0.0328 0.128 0.1386
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0078 0.0005 0.0006
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0519 0.2255 0.2726
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0078 0.0005 0.0005
Brugia malayi hypothetical protein 0.0124 0.024 0.0259
Trichomonas vaginalis CAMK family protein kinase 0.0135 0.0296 0.1
Schistosoma mansoni tyrosine kinase 0.0209 0.0676 0.1425
Trichomonas vaginalis CMGC family protein kinase 0.0159 0.0419 0.1506
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.0156 0.0405 0.163
Brugia malayi P38 map kinase family protein 2 0.0307 0.1172 0.1269
Brugia malayi Temporarily assigned gene name protein 59 0.0124 0.024 0.0259
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0269 0.0978 0.3804
Loa Loa (eye worm) hypothetical protein 0.0174 0.0493 0.0533
Loa Loa (eye worm) TK/FER protein kinase 0.0154 0.0391 0.0423
Brugia malayi tRNA modification GTPase TrmE family protein 0.0078 0.0005 0.0005
Echinococcus multilocularis roundabout 2 0.0087 0.0053 0.0064
Brugia malayi Protein kinase domain containing protein 0.03 0.1135 0.1229
Schistosoma mansoni suppressor of cytokine signaling 0.0078 0.0005 0.001
Echinococcus granulosus defective proboscis extension response 0.0149 0.0367 0.0367
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.047 0.2003 0.2003
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0321 0.1242 0.1345
Schistosoma mansoni tyrosine kinase 0.1008 0.4743 1
Onchocerca volvulus 0.0286 0.1066 0.2478
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0504 0.2178 0.2359
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0143 0.0339 0.0339
Trichomonas vaginalis CK1 family protein kinase 0.0167 0.0457 0.1665
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0167 0.0457 0.1627
Schistosoma mansoni serine/threonine protein kinase 0.0459 0.1949 0.411
Trichomonas vaginalis AGC family protein kinase 0.0564 0.2485 1
Trichomonas vaginalis CMGC family protein kinase 0.0245 0.0858 0.3314
Brugia malayi Immunoglobulin I-set domain containing protein 0.0167 0.046 0.0498
Loa Loa (eye worm) hypothetical protein 0.0384 0.1567 0.1697
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0279 0.1032 0.1247
Echinococcus multilocularis tyrosine protein kinase shark 0.0369 0.149 0.1802
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0381 0.1548 0.1872
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0155 0.0396 0.0836
Trichomonas vaginalis CMGC family protein kinase 0.0154 0.0396 0.1411
Echinococcus granulosus phosphorylase kinase gamma subunit 0.0184 0.0548 0.0548
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0154 0.0396 0.1349
Entamoeba histolytica protein kinase, putative 0.013 0.027 0.1087
Schistosoma mansoni protein kinase 0.0173 0.0491 0.1036
Loa Loa (eye worm) AUR protein kinase 0.0279 0.1032 0.1117
Brugia malayi serine/threonine kinase 12 0.0279 0.1032 0.1117
Onchocerca volvulus 0.0129 0.0268 0.0614
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0155 0.0396 0.1643
Echinococcus multilocularis rac serine:threonine kinase 0.0316 0.1221 0.1476
Loa Loa (eye worm) TK/EPH protein kinase 0.0241 0.0834 0.0904
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0225 0.0757 0.0819
Entamoeba histolytica protein kinase domain containing protein 0.0245 0.0858 0.3455
Schistosoma mansoni tyrosine kinase 0.0581 0.257 0.5419
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0124 0.024 0.029
Schistosoma mansoni serine/threonine protein kinase 0.0132 0.028 0.0589
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.0159 0.0419 0.0453
Plasmodium vivax glycogen synthase kinase 3, putative 0.0245 0.0858 0.7254
Echinococcus multilocularis mitogen activated protein kinase 14 0.0307 0.1172 0.1417
Onchocerca volvulus 0.0318 0.123 0.2862
Trypanosoma cruzi casein kinase, putative 0.0167 0.0457 0.1627
Trypanosoma cruzi serine/arginine-rich protein specific kinase SRPK, putative 0.0103 0.0131 0.0157
Schistosoma mansoni ephrin receptor 0.0094 0.0087 0.0184
Echinococcus multilocularis Immunoglobulin 0.0149 0.0367 0.0444
Brugia malayi Serine/threonine-protein kinase SULU 0.0243 0.0847 0.0917
Plasmodium falciparum serine/threonine protein kinase, putative 0.0279 0.1032 0.8882
Trypanosoma cruzi casein kinase, putative 0.0167 0.0457 0.1627
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0167 0.0457 0.0495
Brugia malayi Furin-like cysteine rich region family protein 0.1008 0.4743 0.5136
Brugia malayi hypothetical protein 0.0154 0.0391 0.0423
Schistosoma mansoni protein kinase 0.0442 0.186 0.3922
Loa Loa (eye worm) AUR protein kinase 0.0279 0.1032 0.1117
Entamoeba histolytica PH domain containing protein kinase, putative 0.0316 0.1221 0.4913
Onchocerca volvulus 0.0154 0.0391 0.0901
Loa Loa (eye worm) hypothetical protein 0.0122 0.023 0.0249
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0173 0.0491 0.2037
Echinococcus granulosus twitchin 0.0237 0.0814 0.0814
Echinococcus multilocularis SH2 motif 0.0078 0.0005 0.0006
Giardia lamblia Kinase, NEK 0.026 0.0935 0.368
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.03 0.1136 0.1374
Trypanosoma brucei protein kinase, putative 0.0245 0.0858 0.3091
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0173 0.0491 0.375
Loa Loa (eye worm) hypothetical protein 0.0173 0.0491 0.0532
Toxoplasma gondii aurora kinase 0.0279 0.1032 0.428
Echinococcus multilocularis c src tyrosine kinase 0.0209 0.0676 0.0817
Schistosoma mansoni hypothetical protein 0.0078 0.0005 0.001
Schistosoma mansoni unc-13 (munc13) 0.0079 0.0013 0.0027
Echinococcus multilocularis SH2 domain containing protein 7 0.0078 0.0005 0.0006
Echinococcus multilocularis cyclin dependent kinase 5 0.0225 0.0757 0.0915
Trichomonas vaginalis CK1 family protein kinase 0.0167 0.0457 0.1665
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.01 0.012 0.0498
Loa Loa (eye worm) hypothetical protein 0.0124 0.024 0.0259
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.04 0.1647 0.1784
Brugia malayi C1-like domain containing protein 0.0356 0.142 0.1538
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0149 0.0367 0.0774
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.0159 0.0419 0.1316
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0173 0.0491 0.0594
Echinococcus granulosus SH2 domain containing protein 7 0.0078 0.0005 0.0005
Entamoeba histolytica protein kinase , putative 0.0279 0.1032 0.4152
Loa Loa (eye worm) hypothetical protein 0.0087 0.0053 0.0057
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0159 0.0419 0.0507
Brugia malayi Protein kinase domain containing protein 0.0154 0.0391 0.0423
Echinococcus multilocularis dual specificity 0.0159 0.0419 0.0506
Echinococcus multilocularis neuroglian 0.0087 0.0053 0.0064
Plasmodium falciparum cGMP-dependent protein kinase 0.0155 0.0396 0.2689
Onchocerca volvulus 0.0079 0.0013 0.0019
Leishmania major protein kinase, putative 0.0174 0.0494 0.1662
Toxoplasma gondii AGC kinase 0.0173 0.0491 0.2037
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0302 0.1146 1
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0279 0.1028 0.1114
Trichomonas vaginalis CAMK family protein kinase 0.03 0.1135 0.4452
Loa Loa (eye worm) hypothetical protein 0.018 0.0528 0.0572
Brugia malayi Fibronectin type III domain containing protein 0.0167 0.046 0.0498
Echinococcus multilocularis SH2 motif 0.0078 0.0005 0.0006
Trichomonas vaginalis STE family protein kinase 0.026 0.0935 0.3631
Onchocerca volvulus 0.0154 0.0391 0.0901
Brugia malayi SH2 domain containing protein 0.0078 0.0005 0.0005
Leishmania major protein kinase A catalytic subunit isoform 1 0.0173 0.0491 0.1648
Echinococcus granulosus tensin 0.0078 0.0005 0.0005
Echinococcus multilocularis tensin 0.0078 0.0005 0.0006
Echinococcus multilocularis insulin receptor 0.071 0.3224 0.3899
Loa Loa (eye worm) TK/FAK protein kinase 0.0593 0.2632 0.285
Trichomonas vaginalis CAMK family protein kinase 0.0532 0.2317 0.931
Schistosoma mansoni serine/threonine protein kinase 0.0106 0.0148 0.0312
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0143 0.0339 0.0883
Schistosoma mansoni hypothetical protein 0.0165 0.0448 0.0944
Brugia malayi hypothetical protein 0.008 0.0015 0.0017
Plasmodium vivax protein kinase Crk2 0.0225 0.0757 0.6284
Brugia malayi SH2 domain containing protein 0.0078 0.0005 0.0005
Schistosoma mansoni serine/threonine protein kinase 0.0195 0.0603 0.127
Schistosoma mansoni serine/threonine protein kinase 0.03 0.1136 0.2396
Brugia malayi Pre-SET motif family protein 0.0251 0.0889 0.0963
Trichomonas vaginalis CMGC family protein kinase 0.0154 0.0396 0.1411
Onchocerca volvulus 0.0519 0.2255 0.5255
Leishmania major protein kinase, putative 0.0156 0.0405 0.1254
Trichomonas vaginalis CMGC family protein kinase 0.0225 0.0757 0.2896
Trichomonas vaginalis CAMK family protein kinase 0.0132 0.028 0.0934
Trichomonas vaginalis set domain proteins, putative 0.0286 0.1066 0.4167
Trichomonas vaginalis CMGC family protein kinase 0.0188 0.0564 0.2105
Trichomonas vaginalis CAMK family protein kinase 0.0132 0.028 0.0934
Echinococcus granulosus protein kinase c epsilon type 0.0379 0.1541 0.1541
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0154 0.0396 0.1641
Giardia lamblia Aurora kinase 0.0279 0.1032 0.412
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0078 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0078 0.0005 0.0005
Echinococcus multilocularis serine threonine protein kinase 0.0383 0.1558 0.1884
Brugia malayi Egg laying defective protein 4 0.0155 0.0396 0.0429
Brugia malayi Protein kinase domain containing protein 0.0321 0.1242 0.1345
Echinococcus multilocularis cyclin dependent kinase 1 0.0225 0.0757 0.0915
Entamoeba histolytica protein kinase domain containing protein 0.0279 0.1032 0.4152
Echinococcus granulosus Vam6:Vps39 protein 0.0124 0.024 0.024
Schistosoma mansoni tyrosine kinase 0.071 0.3224 0.6798
Trichomonas vaginalis AGC family protein kinase 0.0279 0.1032 0.4026
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0328 0.128 0.1547
Echinococcus granulosus SHC transforming protein 3 0.0078 0.0005 0.0005
Brugia malayi Protein kinase domain containing protein 0.03 0.1136 0.1231
Loa Loa (eye worm) CMGC/CDK/CDK7 protein kinase 0.013 0.0269 0.0291
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.4598 0.5559
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0154 0.0396 0.1349
Trichomonas vaginalis CAMK family protein kinase 0.0135 0.0296 0.1
Toxoplasma gondii casein kinase I 0.0167 0.0457 0.1898
Schistosoma mansoni neuroglian 0.0087 0.0053 0.0111
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0174 0.0494 0.1543
Toxoplasma gondii AGC kinase 0.0173 0.0491 0.2037
Echinococcus multilocularis Glutaredoxin protein 5 0.025 0.0882 0.1066
Trichomonas vaginalis AGC family protein kinase 0.0564 0.2485 1
Trichomonas vaginalis CMGC family protein kinase 0.0159 0.0419 0.1506
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0173 0.0491 0.1531
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0245 0.0858 0.1038
Echinococcus granulosus cGMP dependent protein kinase 0.0155 0.0396 0.0396
Echinococcus multilocularis neuroglian 0.0185 0.055 0.0665
Giardia lamblia Kinase, CMGC GSK 0.0245 0.0858 0.3328
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.046 0.1953 0.2361
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0154 0.0396 0.1125
Loa Loa (eye worm) hypothetical protein 0.008 0.0015 0.0017
Loa Loa (eye worm) AGC/PKA protein kinase 0.0173 0.0491 0.0532
Echinococcus granulosus rho-associated protein kinase 1 0.0642 0.2882 0.2882
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.015 0.0372 0.0372
Brugia malayi hypothetical protein 0.0167 0.046 0.0498
Echinococcus multilocularis aurora kinase A 0.0279 0.1032 0.1247
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0078 0.0005 0.001
Trypanosoma brucei cdc2-related kinase 1 0.0225 0.0757 0.2659
Schistosoma mansoni GTPase activating protein 0.0078 0.0005 0.001
Entamoeba histolytica casein kinase, putative 0.0167 0.0457 0.1841
Trichomonas vaginalis CMGC family protein kinase 0.0174 0.0494 0.1816
Echinococcus multilocularis tyrosine protein kinase Srms 0.0272 0.0995 0.1203
Echinococcus granulosus serine:threonine protein kinase N2 0.0131 0.0276 0.0276
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.026 0.0935 0.7988
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0232 0.0792 0.0858
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.03 0.1136 0.1136
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0095 0.0092 0.01
Onchocerca volvulus 0.0154 0.0391 0.0901
Schistosoma mansoni tyrosine kinase 0.0587 0.2601 0.5484
Brugia malayi Protein kinase domain containing protein 0.0103 0.0131 0.0142
Schistosoma mansoni tyrosine kinase 0.0292 0.1094 0.2306
Echinococcus multilocularis roundabout 2 0.0236 0.0812 0.0981
Echinococcus granulosus mitogen activated protein kinase 14 0.0307 0.1172 0.1172
Echinococcus granulosus calcium activated potassium channel 0.0217 0.0712 0.0712
Loa Loa (eye worm) hypothetical protein 0.0167 0.046 0.0498
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative 0.0132 0.028 0.068
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0156 0.0405 0.1392
Echinococcus granulosus STE20 serine:threonine protein kinase 0.0518 0.2249 0.2249
Echinococcus multilocularis signal transduction protein lnk realted 0.0078 0.0005 0.0006
Entamoeba histolytica protein kinase, putative 0.0115 0.0196 0.0787
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.015 0.0372 0.045
Schistosoma mansoni serine/threonine protein kinase 0.0174 0.0494 0.1042
Schistosoma mansoni unc-13 (munc13) 0.0079 0.0013 0.0027
Brugia malayi phosphoinositide-dependent protein kinase I 0.015 0.0372 0.0403
Brugia malayi SRC-1 0.0328 0.128 0.1386
Loa Loa (eye worm) AGC/PKG protein kinase 0.0155 0.0396 0.0429
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0232 0.0792 0.3135
Brugia malayi cytokine inducible SH2-containing protein 5 0.0078 0.0005 0.0005
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0307 0.1172 0.4845
Echinococcus granulosus mitogen activated protein kinase 0.0154 0.0396 0.0396
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0078 0.0005 0.0005
Entamoeba histolytica protein kinase, putative 0.0159 0.0419 0.1686
Schistosoma mansoni serine/threonine protein kinase 0.0536 0.2341 0.4937
Echinococcus granulosus nervana 2 0.025 0.0882 0.0882
Echinococcus granulosus serine/threonine protein kinase 0.0316 0.1221 0.1221
Echinococcus multilocularis dual specificity 0.0232 0.0792 0.0958
Schistosoma mansoni protein kinase 0.048 0.2054 0.4331
Brugia malayi protein kinase C3,putative 0.0296 0.1118 0.1211
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0173 0.0491 0.1531
Schistosoma mansoni tensin 0.0078 0.0005 0.001
Schistosoma mansoni titin 0.0106 0.0148 0.0312
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.0625 0.2793 0.3024
Loa Loa (eye worm) casein kinase 0.0182 0.0537 0.0581
Brugia malayi Protein kinase domain containing protein 0.0154 0.0391 0.0423
Echinococcus multilocularis protein kinase c iota type 0.0544 0.2382 0.288
Plasmodium falciparum serine/threonine protein kinase 0.0103 0.0131 0.0105
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0124 0.024 0.0505
Trichomonas vaginalis STE family protein kinase 0.0159 0.0419 0.1508
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.0156 0.0405 0.1165
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.025 0.0882 0.0882
Plasmodium falciparum calcium-dependent protein kinase 5 0.0143 0.0339 0.2131
Echinococcus granulosus CDC7 cell division cycle 7 0.0109 0.0165 0.0165
Loa Loa (eye worm) hypothetical protein 0.0384 0.1567 0.1697
Brugia malayi RhoGAP domain containing protein 0.0155 0.0396 0.0429
Giardia lamblia Kinase, AGC PKA 0.0173 0.0491 0.1648
Entamoeba histolytica protein kinase domain containing protein 0.0223 0.0746 0.3004
Echinococcus granulosus myotubularin protein 13 0.0091 0.0074 0.0074
Brugia malayi Immunoglobulin I-set domain containing protein 0.0512 0.2219 0.2403
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.0625 0.2793 0.3024
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0087 0.0053 0.0057
Loa Loa (eye worm) SH2 domain-containing protein 0.0078 0.0005 0.0005
Trichomonas vaginalis CMGC family protein kinase 0.0188 0.0564 0.2105
Trichomonas vaginalis CAMK family protein kinase 0.0132 0.028 0.0934
Echinococcus granulosus tyrosine protein kinase HCK 0.0194 0.0598 0.0598
Trichomonas vaginalis CAMK family protein kinase 0.0132 0.028 0.0934
Schistosoma mansoni tyrosine kinase 0.0145 0.0346 0.0729
Entamoeba histolytica protein kinase, putative 0.0194 0.0598 0.2408
Schistosoma mansoni kinase 0.0569 0.2507 0.5285
Trichomonas vaginalis CMGC family protein kinase 0.0159 0.0419 0.1506
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0173 0.0491 0.1779
Loa Loa (eye worm) AGC/AKT protein kinase 0.0564 0.2485 0.269
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0222 0.0739 0.08
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0173 0.0491 0.0491
Trypanosoma cruzi casein kinase, putative 0.0167 0.0457 0.1627
Echinococcus granulosus casein kinase I alpha 0.0167 0.0457 0.0457
Loa Loa (eye worm) hypothetical protein 0.0218 0.0717 0.0777
Echinococcus granulosus calcium dependent protein kinase 0.0091 0.0074 0.0074
Loa Loa (eye worm) AGC/NDR protein kinase 0.03 0.1136 0.1231
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0173 0.0491 0.1531
Brugia malayi Protein kinase domain containing protein 0.0472 0.2013 0.218
Brugia malayi SH2 domain containing protein 0.0154 0.0391 0.0423
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0078 0.0005 0.0006
Onchocerca volvulus 0.0154 0.0391 0.0901
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0391 0.16 0.16
Echinococcus granulosus NDR protein kinase 0.03 0.1136 0.1136
Loa Loa (eye worm) hypothetical protein 0.0149 0.0367 0.0398
Echinococcus granulosus cyclin dependent kinase 7 0.013 0.0269 0.0269
Loa Loa (eye worm) hypothetical protein 0.0078 0.0005 0.0005
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0143 0.0339 0.1405
Trichomonas vaginalis CMGC family protein kinase 0.0225 0.0757 0.2896
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0356 0.142 0.1538
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0454 0.1923 0.2083
Echinococcus multilocularis SH2 motif 0.0078 0.0005 0.0006
Echinococcus granulosus suppressor of cytokine signaling 6 0.0078 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0218 0.0719 0.0778
Brugia malayi SH2 domain containing protein 0.0078 0.0005 0.0005
Trypanosoma brucei protein kinase, putative 0.0128 0.0259 0.0543
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0225 0.0757 0.2863
Onchocerca volvulus Serine\/threonine kinase homolog 0.0184 0.0548 0.1269
Trichomonas vaginalis CMGC family protein kinase 0.0188 0.0564 0.2105
Echinococcus granulosus SH2 motif 0.0078 0.0005 0.0005
Trichomonas vaginalis CAMK family protein kinase 0.0132 0.028 0.0934
Onchocerca volvulus 0.0245 0.0858 0.1994
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0532 0.2317 0.2317
Onchocerca volvulus Tyrosine kinase homolog 0.0918 0.4286 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0328 0.128 0.1547
Echinococcus multilocularis protein tyrosine kinase 0.0587 0.2601 0.3145
Schistosoma mansoni tensin-related 0.0078 0.0005 0.001
Echinococcus granulosus Immunoglobulin 0.0149 0.0367 0.0367
Echinococcus granulosus cGMP dependent protein kinase 1 0.0155 0.0396 0.0396
Loa Loa (eye worm) hypothetical protein 0.0134 0.029 0.0314
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.0156 0.0405 0.163
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0225 0.0757 0.0819
Brugia malayi SH2 domain containing protein 0.0078 0.0005 0.0005
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.0243 0.0847 0.0917
Echinococcus granulosus protein kinase c iota type 0.0544 0.2382 0.2382
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0143 0.0339 0.0409
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0078 0.0005 0.0006
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0087 0.0053 0.0111
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0327 0.1272 0.1378
Entamoeba histolytica protein kinase domain containing protein 0.0159 0.0419 0.1685
Loa Loa (eye worm) TK/FER protein kinase 0.0154 0.0391 0.0423
Giardia lamblia Kinase, CMGC GSK 0.0245 0.0858 0.3328
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0477 0.2036 0.2462
Loa Loa (eye worm) TK/FER protein kinase 0.0154 0.0391 0.0423
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0782 0.3593 0.3593
Loa Loa (eye worm) hypothetical protein 0.008 0.0017 0.0018
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0135 0.0294 0.0318
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0188 0.0564 0.4448
Echinococcus granulosus raf serine:threonine protein kinase 0.0153 0.0386 0.0386
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0302 0.1146 0.4729
Trypanosoma cruzi cdc2-related kinase 1 0.0225 0.0757 0.2975
Brugia malayi Protein kinase domain containing protein 0.0519 0.2255 0.2442
Echinococcus granulosus hypothetical protein 0.0078 0.0005 0.0005
Echinococcus multilocularis tyrosine protein kinase Abl 0.0209 0.0676 0.0817
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0442 0.186 0.186
Entamoeba histolytica protein kinase, putative 0.0564 0.2485 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0154 0.0396 0.1349
Trichomonas vaginalis CMGC family protein kinase 0.0188 0.0564 0.2105
Echinococcus granulosus casein kinase ii subunit alpha 0.0188 0.0564 0.0564
Brugia malayi Protein kinase domain containing protein 0.0154 0.0391 0.0423
Leishmania major casein kinase, putative 0.0167 0.0457 0.1494
Schistosoma mansoni tensin 0.0078 0.0005 0.001
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0134 0.029 0.0611
Schistosoma mansoni growth factor receptor-bound protein 0.0134 0.029 0.0611
Echinococcus multilocularis casein kinase ii subunit alpha 0.0188 0.0564 0.0682
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0245 0.0858 0.0858
Entamoeba histolytica PH domain containing protein kinase, putative 0.0316 0.1221 0.4913
Echinococcus multilocularis epidermal growth factor receptor 0.1008 0.4743 0.5735
Echinococcus multilocularis ephrin type A receptor 4 A 0.0205 0.0654 0.079
Trichomonas vaginalis CAMK family protein kinase 0.0532 0.2317 0.931
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0078 0.0005 0.0005
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0279 0.1032 0.8905
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0132 0.028 0.0632
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.055 0.241 0.261
Loa Loa (eye worm) hypothetical protein 0.0182 0.0536 0.0581
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0155 0.0396 0.0479
Schistosoma mansoni serine/threonine protein kinase 0.0459 0.1949 0.411
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0154 0.0396 0.1211
Trichomonas vaginalis AGC family protein kinase 0.0321 0.1242 0.489
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0154 0.0391 0.0472
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0782 0.3593 0.3891
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0124 0.024 0.0647
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0078 0.0005 0.0006
Trichomonas vaginalis AGC family protein kinase 0.0279 0.1032 0.4026
Leishmania major protein kinase A catalytic subunit 0.0173 0.0491 0.1648
Echinococcus granulosus tyrosine protein kinase Srms 0.0566 0.249 0.249
Entamoeba histolytica protein kinase, putative 0.013 0.027 0.1087
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.0223 0.0746 0.0902
Schistosoma mansoni hypothetical protein 0.0165 0.0448 0.0944
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0115 0.0193 0.0438
Trichomonas vaginalis CAMK family protein kinase 0.0532 0.2317 0.931
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0328 0.128 0.1547
Echinococcus granulosus roundabout 2 0.0087 0.0053 0.0053
Brugia malayi hypothetical protein 0.0243 0.0847 0.0917
Echinococcus multilocularis epidermal growth factor receptor 0.0657 0.2956 0.3574
Giardia lamblia Kinase, CAMK CAMKL 0.0132 0.028 0.068
Trichomonas vaginalis CAMK family protein kinase 0.0132 0.028 0.0934
Brugia malayi Kinase associated domain 1 family protein 0.0165 0.0448 0.0485
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0124 0.024 0.0462
Schistosoma mansoni tyrosine kinase 0.0328 0.128 0.2698
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.048 0.2054 0.2483
Schistosoma mansoni serine/threonine protein kinase 0.013 0.0269 0.0567
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0156 0.0405 0.1392
Trichomonas vaginalis CAMK family protein kinase 0.0132 0.028 0.0934
Loa Loa (eye worm) hypothetical protein 0.0242 0.0843 0.0913
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0477 0.2036 0.2462
Schistosoma mansoni tyrosine kinase 0.0328 0.128 0.2698
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0132 0.028 0.0827
Echinococcus granulosus signal transduction protein lnk realted 0.0078 0.0005 0.0005
Loa Loa (eye worm) CAMK protein kinase 0.0106 0.0148 0.016
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0143 0.0339 0.2296
Echinococcus granulosus tyrosine protein kinase Src42A 0.0198 0.0619 0.0619
Brugia malayi Immunoglobulin I-set domain containing protein 0.0087 0.0053 0.0057
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.026 0.0935 0.3881
Entamoeba histolytica protein kinase, putative 0.0245 0.0858 0.3455
Brugia malayi Immunoglobulin I-set domain containing protein 0.0087 0.0053 0.0057
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0245 0.0858 0.3433
Entamoeba histolytica protein kinase, putative 0.0103 0.0131 0.0526
Echinococcus multilocularis dual specificity 0.0159 0.0419 0.0506
Schistosoma mansoni protein kinase C mu 0.0356 0.142 0.2994
Schistosoma mansoni serine/threonine protein kinase 0.0501 0.2159 0.4552
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0328 0.128 0.1547
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0078 0.0005 0.0005
Trypanosoma brucei SNF1-related protein kinases, putative 0.0132 0.028 0.0632
Brugia malayi Protein kinase domain containing protein 0.0564 0.2485 0.269
Loa Loa (eye worm) hypothetical protein 0.0281 0.1038 0.1124
Entamoeba histolytica SH2-protein kinase domain containing protein 0.013 0.0269 0.1082
Trypanosoma cruzi cdc2-related kinase 1 0.0225 0.0757 0.2975
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0106 0.0148 0.016
Loa Loa (eye worm) hypothetical protein 0.0078 0.0005 0.0005
Echinococcus multilocularis dual specificity 0.0159 0.0419 0.0506
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0328 0.128 0.128
Giardia lamblia Kinase, STE STE20 0.0159 0.0419 0.1318
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0132 0.028 0.1732
Loa Loa (eye worm) hypothetical protein 0.0078 0.0005 0.0005
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0379 0.1541 0.1669
Echinococcus granulosus serine:threonine protein kinase 3 0.0504 0.2178 0.2178
Loa Loa (eye worm) hypothetical protein 0.0165 0.0448 0.0485
Brugia malayi Protein kinase domain containing protein 0.0625 0.2793 0.3024
Schistosoma mansoni serine/threonine kinase 0.03 0.1136 0.2396
Trichomonas vaginalis CMGC family protein kinase 0.0225 0.0757 0.2896
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0728 0.3317 0.4011
Entamoeba histolytica hypothetical protein 0.0232 0.0792 0.3188
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0078 0.0005 0.0005
Loa Loa (eye worm) TK/KIN16 protein kinase 0.1064 0.5032 0.5449
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0182 0.0536 0.0536
Echinococcus multilocularis dual specificity protein kinase clk2 0.0174 0.0494 0.0597
Trichomonas vaginalis CMGC family protein kinase 0.0159 0.0419 0.1506
Giardia lamblia Kinase, STE STE20 0.0156 0.0405 0.1254
Brugia malayi ephrin receptor 1 precursor 0.0137 0.0305 0.033
Echinococcus granulosus dual specificity 0.0159 0.0419 0.0419
Trypanosoma cruzi polo-like protein kinase, putative 0.0532 0.2317 1
Loa Loa (eye worm) hypothetical protein 0.0167 0.046 0.0498
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0279 0.1032 0.4152
Entamoeba histolytica protein kinase, putative 0.0279 0.1032 0.4152
Schistosoma mansoni growth factor receptor-bound protein 0.0136 0.03 0.0633
Echinococcus multilocularis protein kinase c epsilon type 0.0379 0.1541 0.1863
Trichomonas vaginalis AGC family protein kinase 0.0564 0.2485 1
Entamoeba histolytica hypothetical protein 0.0384 0.1566 0.6301
Trypanosoma cruzi cdc2-related kinase 3 0.0225 0.0757 0.2975
Schistosoma mansoni SH2A 0.0078 0.0005 0.001
Echinococcus granulosus aurora kinase A 0.0279 0.1032 0.1032
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0154 0.0396 0.0428
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0128 0.0259 0.0543
Plasmodium falciparum casein kinase 1 0.0167 0.0457 0.3287
Trypanosoma cruzi polo-like protein kinase, putative 0.0532 0.2317 1
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0132 0.028 0.0303
Schistosoma mansoni serine/threonine protein kinase 0.015 0.0372 0.0785
Echinococcus multilocularis casein kinase I alpha 0.0167 0.0457 0.0553
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0154 0.0391 0.1572
Echinococcus granulosus tyrosine protein kinase shark 0.0369 0.149 0.149
Echinococcus multilocularis serine:threonine protein kinase 0.0216 0.0708 0.0857
Loa Loa (eye worm) hypothetical protein 0.0078 0.0005 0.0005
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.03 0.1135 0.1229
Echinococcus multilocularis expressed protein 0.0103 0.0131 0.0158
Giardia lamblia Kinase, NEK 0.026 0.0935 0.368
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0124 0.024 0.024
Onchocerca volvulus 0.0109 0.0165 0.0375
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0143 0.0339 0.0367
Echinococcus granulosus tyrosine protein kinase ABL1 0.0154 0.0391 0.0391
Brugia malayi STE20-like kinase MST 0.0504 0.2178 0.2359
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0174 0.0494 0.1793
Onchocerca volvulus 0.0227 0.0764 0.1774
Schistosoma mansoni tyrosine kinase 0.0209 0.0676 0.1425
Trypanosoma cruzi cdc2-related kinase 3 0.0225 0.0757 0.2975
Brugia malayi Protein kinase domain containing protein 0.0154 0.0391 0.0423
Plasmodium falciparum glycogen synthase kinase 3 0.0245 0.0858 0.7194
Schistosoma mansoni serine/threonine protein kinase 0.0225 0.0757 0.1596
Brugia malayi Hr1 repeat family protein 0.0431 0.1804 0.1954
Loa Loa (eye worm) hypothetical protein 0.0304 0.1156 0.1252
Echinococcus granulosus Glutaredoxin protein 5 0.025 0.0882 0.0882
Loa Loa (eye worm) TK/INSR protein kinase 0.071 0.3224 0.3492
Loa Loa (eye worm) hypothetical protein 0.0078 0.0005 0.0005
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.0096 0.0202
Schistosoma mansoni tyrosine kinase 0.0581 0.257 0.5419
Trichomonas vaginalis mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative 0.0096 0.0096 0.018
Echinococcus granulosus contactin 0.0087 0.0053 0.0053
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0173 0.0491 0.0532
Schistosoma mansoni hypothetical protein 0.0078 0.0005 0.001
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0087 0.0053 0.0064
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0442 0.186 0.2249
Entamoeba histolytica protein kinase domain containing protein 0.0128 0.0259 0.1041
Brugia malayi SH2 domain containing protein 0.0078 0.0005 0.0005
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0245 0.0858 0.093
Echinococcus granulosus NCK adaptor protein 0.0134 0.029 0.029
Trichomonas vaginalis CMGC family protein kinase 0.0188 0.0564 0.2105
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0279 0.1032 0.4152
Schistosoma mansoni serine/threonine protein kinase 0.0154 0.0396 0.0834
Echinococcus granulosus tyrosine kinase 0.0154 0.0391 0.0391
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.025 0.0882 0.1066
Echinococcus multilocularis casein kinase I alpha 0.0167 0.0457 0.0553
Brugia malayi Immunoglobulin I-set domain containing protein 0.1064 0.5032 0.5449
Entamoeba histolytica tyrosin kinase, putative 0.0082 0.0027 0.0109
Echinococcus granulosus casein kinase I alpha 0.0167 0.0457 0.0457
Loa Loa (eye worm) TK/FER protein kinase 0.0154 0.0391 0.0423
Leishmania major protein kinase, putative 0.0279 0.1032 0.412
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0143 0.0339 0.0409
Plasmodium falciparum protein serine/threonine kinase-1 0.0174 0.0494 0.3644
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.03 0.1136 0.1136
Schistosoma mansoni serine/threonine protein kinase 0.0217 0.0712 0.1501
Trypanosoma cruzi aurora B kinase, putative 0.0279 0.1032 0.4213
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.015 0.0372 0.0403
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0087 0.0053 0.0053
Echinococcus granulosus dual specificity 0.0159 0.0419 0.0419
Echinococcus multilocularis casein kinase i 0.0167 0.0457 0.0553
Loa Loa (eye worm) hypothetical protein 0.0132 0.028 0.0303
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0087 0.0053 0.0064
Trichomonas vaginalis CAMK family protein kinase 0.0132 0.028 0.0934
Schistosoma mansoni protein kinase 0.0167 0.0457 0.0964

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.4147 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 0.5623 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.5104 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 141.2538 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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