Detailed information for compound 1363748

Basic information

Technical information
  • TDR Targets ID: 1363748
  • Name: 2-[4-[(3,4,5-trimethoxyphenyl)amino]quinazoli n-2-yl]sulfanylacetonitrile
  • MW: 382.436 | Formula: C19H18N4O3S
  • H donors: 1 H acceptors: 3 LogP: 3.96 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CCSc1nc(Nc2cc(OC)c(c(c2)OC)OC)c2c(n1)cccc2
  • InChi: 1S/C19H18N4O3S/c1-24-15-10-12(11-16(25-2)17(15)26-3)21-18-13-6-4-5-7-14(13)22-19(23-18)27-9-8-20/h4-7,10-11H,9H2,1-3H3,(H,21,22,23)
  • InChiKey: BVORSZLOYXWNMU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[4-[(3,4,5-trimethoxyphenyl)amino]-2-quinazolinyl]thio]acetonitrile
  • 2-[[4-[(3,4,5-trimethoxyphenyl)amino]quinazolin-2-yl]thio]acetonitrile
  • 2-[4-[(3,4,5-trimethoxyphenyl)amino]quinazolin-2-yl]sulfanylethanenitrile
  • SMR000031157
  • EU-0061889
  • ({4-[(3,4,5-trimethoxyphenyl)amino]quinazolin-2-yl}thio)acetonitrile
  • MLS000095606

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0261 0.0828 0.1651
Schistosoma mansoni protein kinase 0.0186 0.0466 0.0938
Giardia lamblia Kinase, CMGC MAPK 0.0181 0.044 0.2664
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative 0.0168 0.0377 0.2201
Trypanosoma cruzi Protein kinase B 0.0363 0.1325 0.9071
Brugia malayi SRC-1 0.0256 0.0806 0.0801
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0348 0.1252 1
Echinococcus granulosus dual specificity 0.0269 0.0869 0.1673
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0107 0.0084 0.0161
Entamoeba histolytica protein kinase domain containing protein 0.0186 0.0465 0.1467
Brugia malayi Protein kinase domain containing protein 0.0179 0.0433 0.0428
Plasmodium falciparum protein serine/threonine kinase-1 0.0341 0.1219 0.9718
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0341 0.1219 0.8305
Trichomonas vaginalis STE family protein kinase 0.0301 0.1024 0.3585
Entamoeba histolytica protein kinase 2, putative 0.0348 0.1252 0.4407
Trichomonas vaginalis mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative 0.0114 0.0116 0.0209
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0073 0.0047
Loa Loa (eye worm) hypothetical protein 0.0318 0.1109 0.1109
Trichomonas vaginalis CMGC family protein kinase 0.0261 0.0831 0.2867
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0341 0.1219 0.1219
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0099 0.0044 0.0089
Onchocerca volvulus 0.0174 0.0406 0.1182
Echinococcus granulosus twitchin 0.02 0.0536 0.1032
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0764 0.3273 0.3269
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0256 0.0806 0.1608
Onchocerca volvulus 0.0113 0.0111 0.0323
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0143 0.0257 0.0513
Schistosoma mansoni serine/threonine protein kinase 0.0539 0.2178 0.4389
Schistosoma mansoni serine/threonine protein kinase 0.0129 0.0188 0.0379
Schistosoma mansoni serine/threonine protein kinase 0.0107 0.0084 0.0169
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.0183 0.0451 0.1412
Schistosoma mansoni cell adhesion molecule 0.0138 0.0234 0.0471
Giardia lamblia Kinase, AGC PKA 0.0202 0.0542 0.3396
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0181 0.044 0.2664
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.022 0.0631 0.1258
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0168 0.0377 0.2576
Schistosoma mansoni serine/threonine protein kinase 0.0168 0.0377 0.0759
Schistosoma mansoni serine/threonine protein kinase 0.0202 0.0542 0.1091
Trichomonas vaginalis CAMK family protein kinase 0.0168 0.0377 0.1177
Loa Loa (eye worm) STE/STE20/SLK protein kinase 0.0431 0.1655 0.1655
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0126 0.0174 0.0335
Echinococcus granulosus aurora kinase A 0.0257 0.0812 0.1562
Entamoeba histolytica protein kinase domain containing protein 0.0284 0.0941 0.3244
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0284 0.094 0.1875
Schistosoma mansoni ephrin receptor 0.013 0.0193 0.0388
Leishmania major casein kinase II, putative 0.0218 0.0623 0.3985
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0121 0.0152 0.0572
Onchocerca volvulus 0.0228 0.0668 0.1946
Schistosoma mansoni serine/threonine protein kinase 0.0277 0.0908 0.1829
Brugia malayi serine/threonine-protein kinase 6 0.0257 0.0812 0.0806
Brugia malayi Protein kinase domain containing protein 0.0204 0.0555 0.0549
Giardia lamblia Kinase, STE STE20 0.0183 0.0451 0.2738
Loa Loa (eye worm) hypothetical protein 0.0118 0.0137 0.0137
Echinococcus multilocularis mitogen activated protein kinase 3 0.0181 0.044 0.0878
Echinococcus granulosus tyrosine kinase 0.0213 0.0596 0.1147
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0238 0.0718 0.0718
Echinococcus multilocularis casein kinase i 0.0238 0.0718 0.1432
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0202 0.0542 0.1751
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0168 0.0377 0.2201
Trichomonas vaginalis AGC family protein kinase 0.0257 0.0812 0.2795
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0797 0.3435 0.3435
Schistosoma mansoni serine/threonine protein kinase 0.022 0.0631 0.1271
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0272 0.0882 0.0882
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0218 0.0623 0.0623
Loa Loa (eye worm) TK/FER protein kinase 0.0113 0.0111 0.0111
Trypanosoma brucei aurora B kinase 0.0257 0.0812 0.2761
Brugia malayi Variant SH3 domain containing protein 0.0143 0.0257 0.0251
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0284 0.0941 0.0941
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0269 0.0869 0.5771
Echinococcus granulosus casein kinase ii subunit alpha 0.0218 0.0623 0.1199
Trichomonas vaginalis STE family protein kinase 0.0186 0.0466 0.1509
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0168 0.0377 0.0377
Onchocerca volvulus 0.067 0.2817 0.8202
Schistosoma mansoni serine/threonine protein kinase 0.0181 0.044 0.0887
Brugia malayi Protein kinase domain containing protein 0.0261 0.0831 0.0826
Brugia malayi Protein kinase domain containing protein 0.0449 0.1744 0.1739
Entamoeba histolytica protein kinase, putative 0.0223 0.0645 0.2138
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0261 0.0831 0.5494
Plasmodium vivax glycogen synthase kinase 3, putative 0.0284 0.0941 0.736
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0893 0.3899 0.3899
Schistosoma mansoni serine/threonine protein kinase 0.0168 0.0377 0.0759
Loa Loa (eye worm) hypothetical protein 0.0113 0.0111 0.0111
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0168 0.0377 0.0751
Onchocerca volvulus 0.0284 0.0941 0.2739
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0358 0.13 0.2501
Brugia malayi p70 ribosomal S6 kinase beta 0.0641 0.2677 0.2673
Loa Loa (eye worm) hypothetical protein 0.1058 0.4702 0.4702
Echinococcus multilocularis activin receptor type 0.0121 0.0152 0.0302
Trichomonas vaginalis AGC family protein kinase 0.0257 0.0812 0.2795
Plasmodium vivax serine/threonine kinase-1, putative 0.0341 0.1219 0.9718
Schistosoma mansoni serine/threonine protein kinase 0.049 0.1944 0.3916
Echinococcus multilocularis mitogen activated protein kinase 11 0.0354 0.128 0.2553
Schistosoma mansoni tyrosine kinase 0.0774 0.3323 0.6695
Leishmania major protein kinase A catalytic subunit isoform 2 0.0202 0.0542 0.3396
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.018 0.0435 0.1392
Trichomonas vaginalis CMGC family protein kinase 0.0218 0.0623 0.2092
Schistosoma mansoni hypothetical protein 0.0152 0.03 0.0604
Schistosoma mansoni serine/threonine protein kinase 0.0539 0.2178 0.4389
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0181 0.044 0.1374
Echinococcus granulosus protein kinase C gamma type 0.0452 0.1755 0.3378
Echinococcus granulosus cGMP dependent protein kinase 1 0.018 0.0435 0.0838
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0256 0.0806 0.1552
Schistosoma mansoni serine/threonine protein kinase 0.0478 0.1883 0.3793
Schistosoma mansoni serine/threonine protein kinase 0.0356 0.1292 0.2603
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0181 0.044 0.2664
Echinococcus granulosus tyrosine protein kinase Fyn 0.0256 0.0806 0.1552
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0292 0.098 0.1955
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0256 0.0806 0.1608
Schistosoma mansoni tyrosine kinase 0.0156 0.0321 0.0647
Echinococcus multilocularis dual specificity 0.0269 0.0869 0.1734
Echinococcus multilocularis cyclin dependent kinase 0.0261 0.0831 0.1657
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0179 0.0433 0.2613
Toxoplasma gondii casein kinase I 0.0238 0.0718 0.2478
Trichomonas vaginalis CAMK family protein kinase 0.0389 0.1453 0.518
Schistosoma mansoni tyrosine kinase 0.0129 0.0189 0.0381
Loa Loa (eye worm) hypothetical protein 0.0228 0.0668 0.0668
Entamoeba histolytica protein kinase , putative 0.0257 0.0812 0.2761
Onchocerca volvulus 0.0113 0.0111 0.0323
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0341 0.1219 0.8305
Schistosoma mansoni serine/threonine protein kinase 0.0365 0.1335 0.2691
Trichomonas vaginalis AGC family protein kinase 0.0396 0.1485 0.5297
Entamoeba histolytica hypothetical protein 0.0432 0.1658 0.5924
Brugia malayi intracellular kinase 0.0284 0.0941 0.0936
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0408 0.1545 0.154
Plasmodium falciparum calcium-dependent protein kinase 3 0.022 0.0631 0.4733
Schistosoma mansoni vesicular amine transporter 0.0106 0.0077 0.0155
Echinococcus granulosus N chimaerin 0.0143 0.0257 0.0495
Echinococcus granulosus mitogen activated protein kinase 3 0.0181 0.044 0.0848
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0213 0.0596 0.1147
Entamoeba histolytica PH domain containing protein kinase, putative 0.0216 0.0614 0.2022
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0106 0.0077 0.0155
Loa Loa (eye worm) CMGC/SRPK protein kinase 0.0179 0.0433 0.0433
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0277 0.0908 0.1811
Schistosoma mansoni protein kinase C mu 0.0408 0.1545 0.3112
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0186 0.0466 0.0929
Trypanosoma cruzi casein kinase, putative 0.0238 0.0718 0.4675
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0186 0.0466 0.0896
Schistosoma mansoni kinase 0.054 0.2184 0.44
Onchocerca volvulus 0.0318 0.1109 0.3228
Trichomonas vaginalis conserved hypothetical protein 0.0122 0.0154 0.0348
Echinococcus granulosus casein kinase I delta 0.0238 0.0718 0.1382
Loa Loa (eye worm) AUR protein kinase 0.0257 0.0812 0.0812
Schistosoma mansoni protein kinase 0.0431 0.1655 0.3335
Brugia malayi Serine/threonine-protein kinase SULU 0.0498 0.1983 0.1978
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.0186 0.0465 0.2844
Echinococcus granulosus protein kinase shaggy 0.0284 0.0941 0.1811
Echinococcus granulosus protein kinase c iota type 0.0635 0.2646 0.5092
Schistosoma mansoni serine/threonine protein kinase 0.0341 0.1219 0.2456
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0765 0.3276 0.3276
Trichomonas vaginalis CK1 family protein kinase 0.0238 0.0718 0.2446
Plasmodium falciparum casein kinase 1 0.0238 0.0718 0.5471
Plasmodium falciparum calcium-dependent protein kinase 4 0.022 0.0631 0.4733
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0174 0.041 0.1296
Trichomonas vaginalis CAMK family protein kinase 0.0389 0.1453 0.518
Plasmodium vivax tyrosine kinase-like protein, putative 0.0174 0.041 0.286
Trypanosoma cruzi casein kinase, putative 0.0238 0.0718 0.4675
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0099 0.0044 0.0044
Brugia malayi Stress-activated protein kinase jnk-1 0.0595 0.2451 0.2447
Schistosoma mansoni protein kinase 0.0801 0.3454 0.6958
Echinococcus multilocularis insulin receptor 0.0774 0.3323 0.6627
Entamoeba histolytica casein kinase, putative 0.0218 0.0623 0.2055
Brugia malayi Protein kinase domain containing protein 0.0303 0.1035 0.103
Echinococcus granulosus cyclin dependent kinase 1 0.0261 0.0831 0.1599
Schistosoma mansoni serine/threonine protein kinase 0.0574 0.2348 0.4731
Toxoplasma gondii acetyl-coA carboxylase ACC2 0.0193 0.0499 0.1635
Brugia malayi Variant SH3 domain containing protein 0.0099 0.0044 0.0038
Trichomonas vaginalis CAMK family protein kinase 0.0168 0.0377 0.1177
Trichomonas vaginalis CAMK family protein kinase 0.0168 0.0377 0.1177
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0106 0.0077 0.0155
Giardia lamblia Aurora kinase 0.0257 0.0812 0.5354
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0158 0.033 0.0658
Echinococcus granulosus STE20 serine:threonine protein kinase 0.1123 0.5015 0.9651
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0156 0.0321 0.0647
Loa Loa (eye worm) hypothetical protein 0.0156 0.0321 0.0321
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0257 0.0812 0.6265
Echinococcus multilocularis mitogen activated protein kinase 0.0181 0.044 0.0878
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0174 0.0406 0.2415
Trichomonas vaginalis CAMK family protein kinase 0.0168 0.0377 0.1177
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0356 0.1292 0.2487
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0202 0.0542 0.1751
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0449 0.1744 0.1744
Brugia malayi Protein kinase domain containing protein 0.0381 0.1412 0.1407
Brugia malayi Protein kinase domain containing protein 0.0329 0.1162 0.1156
Leishmania major protein kinase A catalytic subunit isoform 1 0.0202 0.0542 0.3396
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.022 0.0631 0.2144
Trichomonas vaginalis CAMK family protein kinase 0.0168 0.0377 0.1177
Giardia lamblia Kinase, CDC7 0.0129 0.0188 0.0836
Trichomonas vaginalis CAMK family protein kinase 0.017 0.039 0.1226
Schistosoma mansoni adapter molecule crk 0.0099 0.0044 0.0089
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0202 0.0542 0.18
Echinococcus multilocularis 0.0277 0.0907 0.1809
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.0257 0.081 0.081
Brugia malayi Carboxyl transferase domain containing protein 0.0186 0.0466 0.046
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0356 0.1292 0.2577
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0186 0.0466 0.0929
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0389 0.1453 1
Echinococcus multilocularis dual specificity 0.0186 0.0465 0.0928
Echinococcus multilocularis expressed conserved protein 0.018 0.0435 0.0868
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.022 0.0631 0.1214
Echinococcus multilocularis hypothetical protein 0.0152 0.03 0.0598
Trichomonas vaginalis STE family protein kinase 0.0183 0.0451 0.1452
Entamoeba histolytica protein kinase, putative 0.0186 0.0466 0.1469
Echinococcus granulosus ephrin type A receptor 4 A 0.013 0.0193 0.0371
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0277 0.0908 0.0908
Echinococcus granulosus nervana 2 0.0284 0.094 0.181
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0176 0.0415 0.0415
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.0116 0.0235
Leishmania major protein kinase, putative 0.0341 0.1219 0.8305
Trichomonas vaginalis CMGC family protein kinase 0.0218 0.0623 0.2092
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0256 0.0806 0.1608
Plasmodium falciparum calcium-dependent protein kinase 5 0.022 0.0631 0.4733
Loa Loa (eye worm) hypothetical protein 0.022 0.0631 0.0631
Loa Loa (eye worm) casein kinase 0.0414 0.1571 0.1571
Loa Loa (eye worm) TK/FER protein kinase 0.0113 0.0111 0.0111
Loa Loa (eye worm) TK protein kinase 0.0213 0.0596 0.0596
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0073 0.0047
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0381 0.1412 0.1412
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0202 0.0542 0.1042
Schistosoma mansoni serine/threonine protein kinase 0.0216 0.0612 0.1233
Giardia lamblia Kinase, CAMK CAMKL 0.0168 0.0377 0.2201
Onchocerca volvulus Serine\/threonine kinase homolog 0.0389 0.1453 0.4231
Loa Loa (eye worm) hypothetical protein 0.0205 0.0557 0.0557
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0186 0.0465 0.1467
Brugia malayi Temporarily assigned gene name protein 59 0.0296 0.1 0.0994
Plasmodium vivax calcium-dependent protein kinase, putative 0.022 0.0631 0.4733
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0984 0.4341 0.8355
Echinococcus granulosus homeodomain interacting protein kinase 3 0.0257 0.081 0.156
Echinococcus multilocularis neuroglian 0.0136 0.0224 0.0447
Loa Loa (eye worm) hypothetical protein 0.0246 0.0758 0.0758
Echinococcus granulosus casein kinase I alpha 0.0238 0.0718 0.1382
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0176 0.0415 0.0828
Giardia lamblia Kinase, NEK 0.0301 0.1024 0.6893
Trichomonas vaginalis AGC family protein kinase 0.0257 0.0812 0.2795
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0284 0.0941 0.1877
Brugia malayi Protein kinase domain containing protein 0.0176 0.0415 0.041
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0202 0.0542 0.1042
Schistosoma mansoni tyrosine kinase 0.0256 0.0806 0.1624
Trypanosoma brucei Casein kinase II 0.0218 0.0623 0.2055
Loa Loa (eye worm) hypothetical protein 0.0102 0.0058 0.0058
Brugia malayi Protein kinase domain containing protein 0.0269 0.0869 0.0864
Echinococcus granulosus c-Jun N-terminal kinases 0.0595 0.2451 0.4718
Schistosoma mansoni serine/threonine protein kinase 0.0216 0.0612 0.1233
Giardia lamblia Kinase, CMGC GSK 0.0284 0.0941 0.629
Echinococcus granulosus roundabout 2 0.0169 0.0381 0.0734
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0354 0.128 0.128
Brugia malayi Protein kinase domain containing protein 0.0326 0.1144 0.1139
Loa Loa (eye worm) hypothetical protein 0.0277 0.0907 0.0907
Trichomonas vaginalis CMGC family protein kinase 0.0218 0.0623 0.2092
Giardia lamblia Kinase, CMGC CDK 0.0261 0.0831 0.5494
Trichomonas vaginalis CMGC family protein kinase 0.0218 0.0623 0.2092
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0113 0.0111 0.0221
Echinococcus granulosus tyrosine protein kinase Blk 0.0213 0.0596 0.1147
Schistosoma mansoni tyrosine kinase 0.0299 0.1017 0.2049
Echinococcus multilocularis casein kinase ii subunit alpha 0.0218 0.0623 0.1242
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0269 0.0869 0.5771
Leishmania major casein kinase, putative 0.0238 0.0718 0.4675
Echinococcus granulosus casein kinase I alpha 0.0238 0.0718 0.1382
Trichomonas vaginalis CMGC family protein kinase 0.0186 0.0465 0.1507
Echinococcus granulosus neuroglian 0.0136 0.0224 0.0431
Echinococcus granulosus serine:threonine protein kinase 0.0204 0.0555 0.1068
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0321 0.1121 0.2235
Schistosoma mansoni tyrosine kinase 0.1112 0.4964 1
Echinococcus granulosus protein kinase 0.0272 0.0882 0.1698
Loa Loa (eye worm) hypothetical protein 0.0204 0.0551 0.0551
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0284 0.0941 0.3334
Trichomonas vaginalis AGC family protein kinase 0.0202 0.0542 0.179
Trichomonas vaginalis AGC family protein kinase 0.0656 0.275 1
Schistosoma mansoni serine/threonine protein kinase 0.0261 0.0831 0.1674
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0801 0.3454 0.6888
Schistosoma mansoni serine/threonine protein kinase 0.0202 0.0542 0.1091
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0448 0.1737 0.1737
Echinococcus multilocularis cyclin dependent kinase 1 0.0261 0.0831 0.1657
Plasmodium falciparum calcium-dependent protein kinase 2 0.022 0.0631 0.4733
Echinococcus multilocularis cGMP dependent protein kinase 1 0.018 0.0435 0.0868
Leishmania major protein kinase A catalytic subunit 0.0202 0.0542 0.3396
Plasmodium falciparum serine/threonine protein kinase, putative 0.0257 0.0812 0.6265
Echinococcus granulosus nervana 2 0.0284 0.094 0.181
Plasmodium falciparum casein kinase 2, alpha subunit 0.0218 0.0623 0.4664
Entamoeba histolytica cell division protein kinase 2, putative 0.0261 0.0831 0.2833
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0181 0.044 0.2664
Echinococcus multilocularis mitogen activated protein kinase 14 0.0354 0.128 0.2553
Trichomonas vaginalis STE family protein kinase 0.0186 0.0466 0.1509
Loa Loa (eye worm) TK/FER protein kinase 0.0113 0.0111 0.0111
Trichomonas vaginalis STE family protein kinase 0.0136 0.0224 0.061
Echinococcus granulosus rho-associated protein kinase 1 0.0735 0.3129 0.6023
Onchocerca volvulus 0.0257 0.0809 0.2357
Trypanosoma brucei cdc2-related kinase 3 0.0261 0.0831 0.2833
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0181 0.044 0.2664
Entamoeba histolytica casein kinase 1, putative 0.0238 0.0718 0.2411
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0354 0.128 0.4511
Entamoeba histolytica protein kinase domain containing protein 0.0269 0.0869 0.2976
Loa Loa (eye worm) hypothetical protein 0.0344 0.1233 0.1233
Loa Loa (eye worm) hypothetical protein 0.0676 0.2845 0.2845
Trichomonas vaginalis CAMK family protein kinase 0.0168 0.0377 0.1177
Echinococcus granulosus NCK adaptor protein 0.0099 0.0044 0.0085
Echinococcus multilocularis serine:threonine protein kinase 0.0204 0.0555 0.1107
Schistosoma mansoni serine/threonine protein kinase 0.0105 0.0073 0.0146
Echinococcus multilocularis nervana 2 0.0284 0.094 0.1875
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0202 0.0542 0.3974
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0354 0.128 0.8747
Schistosoma mansoni serine/threonine protein kinase 0.0356 0.1292 0.2603
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0181 0.044 0.2664
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0389 0.1453 0.2797
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0389 0.1453 0.1453
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0397 0.149 0.2972
Entamoeba histolytica protein kinase domain containing protein 0.0284 0.0941 0.3244
Echinococcus granulosus calcium activated potassium channel 0.0216 0.0612 0.1178
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0121 0.0152 0.0302
Schistosoma mansoni serine/threonine protein kinase 0.018 0.0435 0.0877
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0202 0.0542 0.108
Plasmodium falciparum calcium-dependent protein kinase 1 0.022 0.0631 0.4733
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0261 0.0831 0.0831
Echinococcus multilocularis expressed protein 0.0179 0.0433 0.0864
Loa Loa (eye worm) TK/EGFR protein kinase 0.1112 0.4964 0.4964
Trypanosoma cruzi acetyl-CoA carboxylase 0.0119 0.0142 0.0503
Schistosoma mansoni tyrosine kinase 0.0418 0.1593 0.3209
Loa Loa (eye worm) TK protein kinase 0.0205 0.0557 0.0557
Schistosoma mansoni serine/threonine protein kinase 0.0107 0.0082 0.0165
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0284 0.094 0.181
Giardia lamblia Kinase, NEK 0.0301 0.1024 0.6893
Loa Loa (eye worm) protein kinase domain-containing protein 0.0478 0.1883 0.1883
Giardia lamblia Kinase, CAMK CAMKL 0.0168 0.0377 0.2201
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0356 0.1289 0.1289
Echinococcus granulosus epidermal growth factor receptor 0.1112 0.4964 0.9553
Loa Loa (eye worm) hypothetical protein 0.0204 0.0551 0.0551
Echinococcus granulosus CDC7 cell division cycle 7 0.0129 0.0188 0.0362
Entamoeba histolytica protein kinase, putative 0.0284 0.0941 0.3244
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0202 0.0542 0.1042
Echinococcus multilocularis maternal embryonic leucine zipper kinase 0.0158 0.0328 0.0653
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0317 0.11 0.3867
Onchocerca volvulus 0.0519 0.2085 0.6069
Brugia malayi Immunoglobulin I-set domain containing protein 0.0702 0.2973 0.2969
Trypanosoma cruzi cdc2-related kinase 1 0.0261 0.0831 0.5494
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0449 0.1744 0.3355
Echinococcus granulosus acetyl coenzyme A carboxylase 1 0.0193 0.0499 0.0959
Trichomonas vaginalis CAMK family protein kinase 0.0168 0.0377 0.1177
Brugia malayi Casein kinase II, alpha chain 0.0218 0.0623 0.0617
Echinococcus multilocularis protein kinase shaggy 0.0284 0.0941 0.1877
Echinococcus multilocularis tyrosine protein kinase shark 0.0355 0.1288 0.2569
Brugia malayi Protein kinase domain containing protein 0.0113 0.0111 0.0105
Schistosoma mansoni vav2 0.0158 0.033 0.0664
Trichomonas vaginalis CMGC family protein kinase 0.0129 0.0188 0.0476
Brugia malayi Protein kinase c protein 2 0.0245 0.0754 0.0748
Trichomonas vaginalis AGC family protein kinase 0.0176 0.0415 0.1321
Loa Loa (eye worm) AGC/PKG protein kinase 0.018 0.0435 0.0435
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0797 0.3435 0.685
Brugia malayi Temporarily assigned gene name protein 59 0.0228 0.0668 0.0663
Schistosoma mansoni serine/threonine protein kinase 0.0341 0.1219 0.2456
Brugia malayi Protein kinase domain containing protein 0.0431 0.1655 0.165
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.022 0.0631 0.4733
Schistosoma mansoni protein kinase 0.0238 0.0718 0.1447
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0183 0.0451 0.2738
Loa Loa (eye worm) TK/FER protein kinase 0.0113 0.0111 0.0111
Trypanosoma cruzi casein kinase, putative 0.0238 0.0718 0.4675
Trichomonas vaginalis CMGC family protein kinase 0.0186 0.0465 0.1507
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0539 0.2178 0.4344
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0321 0.1122 0.1122
Echinococcus granulosus serine threonine protein kinase nrc 0.0348 0.1252 0.241
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0551 0.2236 0.2236
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0107 0.0084 0.0161
Loa Loa (eye worm) CDC7 protein kinase 0.0129 0.0188 0.0188
Loa Loa (eye worm) camk/dcamkl protein kinase 0.0335 0.1188 0.1188
Entamoeba histolytica protein kinase, putative 0.0269 0.0869 0.2976
Loa Loa (eye worm) hypothetical protein 0.0236 0.0711 0.0711
Loa Loa (eye worm) hypothetical protein 0.0318 0.1109 0.1109
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0257 0.0812 0.2761
Brugia malayi Protein kinase domain containing protein 0.0358 0.13 0.1294
Echinococcus granulosus tyrosine protein kinase ABL1 0.0113 0.0111 0.0213
Echinococcus granulosus growth factor receptor bound protein 2 0.0101 0.0055 0.0107
Loa Loa (eye worm) TK/EPH protein kinase 0.015 0.0289 0.0289
Echinococcus granulosus tyrosine protein kinase shark 0.0355 0.1288 0.2479
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0551 0.2236 0.446
Plasmodium falciparum protein kinase 5 0.0261 0.0831 0.6429
Trypanosoma cruzi polo-like protein kinase, putative 0.0389 0.1453 1
Schistosoma mansoni hypothetical protein 0.0152 0.03 0.0604
Echinococcus multilocularis calcium dependent protein kinase 0.0156 0.0319 0.0636
Loa Loa (eye worm) hypothetical protein 0.0118 0.0137 0.0137
Schistosoma mansoni tyrosine kinase 0.0397 0.149 0.3003
Mycobacterium ulcerans hypothetical protein 0.0115 0.0123 0.5
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.022 0.0631 0.2144
Schistosoma mansoni serine/threonine protein kinase 0.0893 0.3899 0.7854
Loa Loa (eye worm) TK/ALK protein kinase 0.0326 0.1144 0.1144
Echinococcus granulosus tyrosine protein kinase Src42A 0.0256 0.0806 0.1552
Loa Loa (eye worm) hypothetical protein 0.0118 0.0137 0.0137
Brugia malayi serine/threonine-protein kinase plk-2 0.0389 0.1453 0.1448
Onchocerca volvulus 0.0344 0.1233 0.3588
Brugia malayi phosphoinositide-dependent protein kinase I 0.0176 0.0415 0.041
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0801 0.3454 0.3454
Echinococcus granulosus calcium dependent protein kinase 0.0156 0.0319 0.0614
Brugia malayi Protein kinase domain containing protein 0.0113 0.0111 0.0105
Brugia malayi casein kinase 1, delta 0.0238 0.0718 0.0713
Echinococcus multilocularis Glutaredoxin protein 5 0.0284 0.094 0.1875
Brugia malayi SH2 domain containing protein 0.0113 0.0111 0.0105
Echinococcus granulosus tyrosine protein kinase Src42A 0.0158 0.033 0.0635
Trichomonas vaginalis CAMK family protein kinase 0.0168 0.0377 0.1177
Brugia malayi hypothetical protein 0.0113 0.0111 0.0105
Echinococcus multilocularis serine:threonine protein kinase N2 0.0358 0.13 0.2591
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0449 0.1744 0.3477
Trichomonas vaginalis CMGC family protein kinase 0.0218 0.0623 0.2092
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0984 0.4341 0.8657
Giardia lamblia Kinase, CMGC DYRK 0.0186 0.0465 0.2844
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0202 0.0542 0.108
Echinococcus multilocularis tyrosine protein kinase Srms 0.0213 0.0596 0.1188
Loa Loa (eye worm) hypothetical protein 0.0106 0.0077 0.0077
Echinococcus granulosus maternal embryonic leucine zipper kinase 0.0158 0.0328 0.0631
Trichomonas vaginalis CMGC family protein kinase 0.0186 0.0465 0.1507
Brugia malayi Protein kinase domain 0.0186 0.0466 0.046
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0238 0.0718 0.0718
Schistosoma mansoni serine/threonine protein kinase 0.049 0.1944 0.3916
Echinococcus multilocularis acetyl coenzyme A carboxylase 1 0.0193 0.0499 0.0994
Giardia lamblia Kinase, CMGC CDK 0.0261 0.0831 0.5494
Brugia malayi casein kinase I 0.0238 0.0718 0.0713
Echinococcus multilocularis ephrin type A receptor 4 A 0.013 0.0193 0.0384
Echinococcus multilocularis mitogen activated protein kinase 14 0.0354 0.128 0.2553
Echinococcus granulosus protein kinase c epsilon type 0.0448 0.1737 0.3342
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0284 0.0941 0.0941
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0143 0.0257 0.0495
Echinococcus multilocularis serine threonine protein kinase 0.0452 0.1755 0.35
Trichomonas vaginalis CMGC family protein kinase 0.0181 0.044 0.1414
Brugia malayi protein kinase C3,putative 0.0342 0.1221 0.1216
Loa Loa (eye worm) AGC/NDR protein kinase 0.0358 0.13 0.13
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0213 0.0596 0.1188
Leishmania major protein kinase, putative 0.0121 0.0152 0.0572
Echinococcus granulosus RNA directed DNA polymerase 0.0091 0.0004 0.0009
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0114 0.0116 0.0317
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.2149 1 1
Echinococcus multilocularis casein kinase I delta 0.0238 0.0718 0.1432
Loa Loa (eye worm) hypothetical protein 0.0318 0.1109 0.1109
Entamoeba histolytica PH domain containing protein kinase, putative 0.0216 0.0614 0.2022
Trichomonas vaginalis CMGC family protein kinase 0.0284 0.0941 0.3275
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.116 0.5196 1
Entamoeba histolytica protein kinase, putative 0.022 0.0631 0.2086
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0202 0.0542 0.108
Brugia malayi P38 map kinase family protein 2 0.0354 0.128 0.1275
Schistosoma mansoni serine/threonine protein kinase 0.0257 0.081 0.1633
Schistosoma mansoni serine/threonine protein kinase 0.0186 0.0465 0.0937
Trypanosoma brucei polo-like protein kinase 0.0389 0.1453 0.5157
Echinococcus multilocularis CDC7 cell division cycle 7 0.0129 0.0188 0.0375
Schistosoma mansoni protein kinase 0.0136 0.0224 0.0452
Trichomonas vaginalis STE family protein kinase 0.0186 0.0466 0.1509
Loa Loa (eye worm) CAMK protein kinase 0.0107 0.0082 0.0082
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0341 0.1219 0.8305
Echinococcus multilocularis dual specificity 0.0186 0.0465 0.0928
Entamoeba histolytica protein kinase, putative 0.0269 0.0869 0.2976
Echinococcus granulosus NDR protein kinase 0.0358 0.13 0.2501
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0186 0.0466 0.0896
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0257 0.0812 0.0806
Brugia malayi Pleckstrin Homology Domain 0.0102 0.0058 0.0053
Echinococcus multilocularis Immunoglobulin 0.0106 0.0077 0.0153
Echinococcus granulosus casein kinase I gamma 0.0478 0.1883 0.3624
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.0498 0.1983 0.3954
Echinococcus multilocularis dual specificity 0.0186 0.0465 0.0928
Trypanosoma brucei casein kinase I, isoform 2 0.0238 0.0718 0.2411
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0797 0.3435 0.6611
Echinococcus multilocularis death associated protein kinase 1 0.099 0.4371 0.8716
Echinococcus multilocularis casein kinase I delta 0.0238 0.0718 0.1432
Schistosoma mansoni serine/threonine protein kinase 0.0551 0.2236 0.4506
Trichomonas vaginalis AGC family protein kinase 0.0257 0.0812 0.2795
Echinococcus multilocularis tyrosine protein kinase Blk 0.0213 0.0596 0.1188
Echinococcus granulosus Immunoglobulin 0.0106 0.0077 0.0148
Entamoeba histolytica protein kinase, putative 0.012 0.0146 0.0275
Brugia malayi Tyrosine-protein kinase abl-1 0.0156 0.0321 0.0315
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0121 0.0152 0.0303
Echinococcus multilocularis protein kinase c iota type 0.0635 0.2646 0.5277
Brugia malayi C1-like domain containing protein 0.0408 0.1545 0.154
Brugia malayi Immunoglobulin I-set domain containing protein 0.0107 0.0082 0.0076
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0358 0.13 0.2591
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.0186 0.0465 0.1508
Echinococcus multilocularis serine:threonine protein kinase 38 0.0358 0.13 0.2591
Entamoeba histolytica protein kinase domain containing protein 0.0218 0.0623 0.2055
Brugia malayi Protein kinase domain containing protein 0.0341 0.1219 0.1214
Echinococcus granulosus raf serine:threonine protein kinase 0.0144 0.0263 0.0506
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0341 0.1219 0.4283
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0389 0.1453 0.2898
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0787 0.3383 0.6746
Trichomonas vaginalis CAMK family protein kinase 0.0168 0.0377 0.1177
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.0183 0.0451 0.1412
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0702 0.2973 0.2973
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0578 0.2369 0.2369
Trichomonas vaginalis CMGC family protein kinase 0.0181 0.044 0.1414
Loa Loa (eye worm) TK/INSR protein kinase 0.0774 0.3323 0.3323
Entamoeba histolytica protein kinase, putative 0.0656 0.275 1
Giardia lamblia Kinase, STE STE20 0.0186 0.0466 0.2848
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0595 0.2451 0.2451
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0202 0.0542 0.3396
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0121 0.0152 0.0292
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0256 0.0806 0.1608
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0261 0.0828 0.1593
Entamoeba histolytica serine/threonine protein kinase, putative 0.0168 0.0377 0.1135
Echinococcus granulosus serine:threonine protein kinase TAO1 0.0498 0.1983 0.3816
Trichomonas vaginalis CAMK family protein kinase 0.0168 0.0377 0.1177
Trypanosoma cruzi casein kinase II, putative 0.0218 0.0623 0.3985
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0358 0.13 0.2501
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0341 0.1219 0.8305
Loa Loa (eye worm) hypothetical protein 0.0273 0.0888 0.0888
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.022 0.0631 0.4733
Entamoeba histolytica protein kinase, putative 0.0176 0.0415 0.128
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.022 0.0631 0.1214
Giardia lamblia Kinase, CMGC CLK 0.0341 0.1219 0.8305
Brugia malayi protein unc-22 0.0107 0.0082 0.0076
Entamoeba histolytica protein kinase, putative 0.0107 0.0084 0.0041
Echinococcus granulosus hypothetical protein 0.0277 0.0907 0.1746
Schistosoma mansoni tyrosine kinase 0.0658 0.2758 0.5557
Echinococcus multilocularis casein kinase I alpha 0.0238 0.0718 0.1432
Schistosoma mansoni serine/threonine kinase 0.0309 0.1065 0.2145
Echinococcus multilocularis tyrosine protein kinase HCK 0.0157 0.0325 0.0647
Entamoeba histolytica casein kinase, putative 0.0238 0.0718 0.2411
Schistosoma mansoni nck2/grb4 0.0099 0.0044 0.0089
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0121 0.0152 0.0295
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0228 0.0668 0.1286
Brugia malayi Protein kinase domain containing protein 0.0365 0.1335 0.133
Brugia malayi Protein kinase domain containing protein 0.0113 0.0111 0.0105
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0202 0.0542 0.3396
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0127 0.0179 0.0179
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.022 0.0631 0.4733
Plasmodium falciparum NIMA related kinase 1 0.0301 0.1024 0.8066
Echinococcus granulosus c src tyrosine kinase 0.0156 0.0321 0.0618
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0256 0.0806 0.1608
Echinococcus multilocularis dual specificity protein kinase clk2 0.0341 0.1219 0.2431
Echinococcus granulosus phosphorylase kinase gamma subunit 0.0365 0.1335 0.257
Loa Loa (eye worm) CAMK/PHK protein kinase 0.0365 0.1335 0.1335
Leishmania major protein kinase, putative 0.0257 0.0812 0.5354
Brugia malayi Protein kinase domain containing protein 0.0656 0.275 0.2745
Echinococcus granulosus dual specificity 0.0186 0.0465 0.0895
Brugia malayi serine/threonine kinase 12 0.0257 0.0812 0.0806
Schistosoma mansoni serine/threonine protein kinase 0.0168 0.0377 0.0759
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0551 0.2236 0.4304
Trypanosoma cruzi cdc2-related kinase 3 0.0261 0.0831 0.5494
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0301 0.1024 0.3654
Echinococcus granulosus Glutaredoxin protein 5 0.0284 0.094 0.181
Echinococcus granulosus insulin receptor 0.0774 0.3323 0.6395
Loa Loa (eye worm) hypothetical protein 0.0197 0.0519 0.0519
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0459 0.1792 0.3574
Trichomonas vaginalis CMGC family protein kinase 0.0261 0.0831 0.2867
Echinococcus granulosus serine:threonine protein kinase 3 0.0578 0.2369 0.4558
Echinococcus multilocularis STE20 serine:threonine protein kinase 0.1123 0.5015 1
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0202 0.0542 0.108
Echinococcus multilocularis 0.0272 0.0882 0.1759
Schistosoma mansoni serine/threonine protein kinase 0.0179 0.0433 0.0873
Brugia malayi hypothetical protein 0.0228 0.0668 0.0663
Loa Loa (eye worm) hypothetical protein 0.0178 0.0428 0.0428
Toxoplasma gondii AGC kinase 0.0202 0.0542 0.18
Giardia lamblia Kinase, CMGC GSK 0.0284 0.0941 0.629
Loa Loa (eye worm) TK/FER protein kinase 0.0113 0.0111 0.0111
Brugia malayi RhoGAP domain containing protein 0.0143 0.0257 0.0251
Trypanosoma cruzi cdc2-related kinase 1 0.0261 0.0831 0.5494
Schistosoma mansoni tyrosine kinase 0.0107 0.0084 0.017
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0284 0.0941 0.629
Schistosoma mansoni vam6/vps39 related 0.0228 0.0668 0.1347
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0348 0.1252 0.241
Trypanosoma cruzi serine/arginine-rich protein specific kinase SRPK, putative 0.0179 0.0433 0.2613
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0228 0.0668 0.1347
Loa Loa (eye worm) AGC/PKN protein kinase 0.0655 0.2744 0.2744
Schistosoma mansoni nephrin 0.0148 0.0284 0.0572
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.022 0.0631 0.1214
Plasmodium falciparum cGMP-dependent protein kinase 0.018 0.0435 0.3073
Echinococcus granulosus serine/threonine protein kinase 0.0363 0.1325 0.255
Entamoeba histolytica SH2-protein kinase domain containing protein 0.012 0.0146 0.0275
Echinococcus multilocularis cyclin dependent kinase 1 0.0261 0.0831 0.1657
Schistosoma mansoni serine/threonine protein kinase 0.0168 0.0377 0.0759
Trypanosoma cruzi p21-activated kinase 3, putative 0.0114 0.0116 0.0317
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.0186 0.0465 0.046
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0114 0.0116 0.0116
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0181 0.044 0.1412
Trypanosoma cruzi cdc2-related kinase 3 0.0261 0.0831 0.5494
Echinococcus multilocularis calcium activated potassium channel 0.0216 0.0612 0.122
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0435 0.1676 0.3225
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0269 0.0869 0.5771
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0309 0.1065 0.1065
Echinococcus granulosus cyclin dependent kinase 5 0.0261 0.0831 0.1599
Trichomonas vaginalis CMGC family protein kinase 0.0261 0.0831 0.2867
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0272 0.0884 0.5879
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0341 0.1219 0.4283
Loa Loa (eye worm) hypothetical protein 0.0435 0.1676 0.1676
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0186 0.0466 0.0896
Giardia lamblia Kinase, AGC AKT 0.0257 0.0812 0.5354
Entamoeba histolytica protein kinase, putative 0.0151 0.0297 0.0837
Entamoeba histolytica hypothetical protein 0.0269 0.0869 0.2976
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0261 0.0831 0.0831
Brugia malayi Variant SH3 domain containing protein 0.0099 0.0044 0.0038
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0181 0.044 0.2664
Brugia malayi Protein kinase domain containing protein 0.0801 0.3454 0.345
Trichomonas vaginalis CMGC family protein kinase 0.0218 0.0623 0.2092
Brugia malayi Sex muscle abnormal protein 5 0.0099 0.0044 0.0038
Echinococcus multilocularis rho associated protein kinase 0.0735 0.3129 0.6241
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.1018 0.4504 0.4504
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0277 0.0908 0.1748
Brugia malayi serine/threonine-protein kinase PAK 7 0.0521 0.2093 0.2088
Trichomonas vaginalis AGC family protein kinase 0.0656 0.275 1
Plasmodium vivax serine/threonine protein kinase, putative 0.0179 0.0433 0.3058
Entamoeba histolytica protein kinase, putative 0.0179 0.0433 0.1348
Trichomonas vaginalis CAMK family protein kinase 0.0168 0.0377 0.1177
Loa Loa (eye worm) TK/FER protein kinase 0.0113 0.0111 0.0111
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0107 0.0084 0.0167
Entamoeba histolytica protein kinase domain containing protein 0.0257 0.081 0.2756
Schistosoma mansoni serine/threonine protein kinase 0.0238 0.0718 0.1447
Schistosoma mansoni serine/threonine protein kinase 0.0257 0.0812 0.1635
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0107 0.0084 0.0167
Brugia malayi SH2 domain containing protein 0.0261 0.0828 0.0822
Trichomonas vaginalis CAMK family protein kinase 0.022 0.0631 0.2123
Trypanosoma brucei serine/arginine-rich protein specific kinase SRPK, putative 0.0179 0.0433 0.1348
Schistosoma mansoni serine/threonine protein kinase 0.0389 0.1453 0.2928
Entamoeba histolytica p21-activated kinase 0.0201 0.0538 0.174
Echinococcus granulosus expressed protein 0.0179 0.0433 0.0834
Onchocerca volvulus 0.0113 0.0111 0.0323
Schistosoma mansoni titin 0.0107 0.0082 0.0165
Trichomonas vaginalis CAMK family protein kinase 0.0389 0.1453 0.518
Trypanosoma cruzi casein kinase, putative 0.0238 0.0718 0.4675
Echinococcus granulosus myotubularin protein 13 0.0102 0.0058 0.0112
Echinococcus multilocularis tyrosine protein kinase 0.0329 0.1162 0.2316
Toxoplasma gondii cell-cycle-associated protein kinase SRPK, putative 0.0179 0.0433 0.1385
Brugia malayi probable protein kinase 0.0499 0.1988 0.1983
Toxoplasma gondii histone kinase SNF1, putative 0.0168 0.0377 0.1167
Loa Loa (eye worm) hypothetical protein 0.0091 0.0004 0.0004
Entamoeba histolytica protein kinase domain containing protein 0.0257 0.0812 0.2761
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative 0.0168 0.0377 0.2201
Loa Loa (eye worm) TK protein kinase 0.0427 0.1638 0.1638
Echinococcus granulosus fibroblast growth factor receptor 4 0.0397 0.149 0.2868
Loa Loa (eye worm) hypothetical protein 0.0228 0.0668 0.0668
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.022 0.0631 0.1258
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0797 0.3435 1
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0341 0.1219 0.4402
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0256 0.0806 0.1608
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0176 0.0415 0.0799
Echinococcus granulosus serine:threonine protein kinase N2 0.0297 0.1007 0.1938
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0202 0.0542 0.3396
Brugia malayi hypothetical protein 0.0118 0.0137 0.0131
Entamoeba histolytica protein kinase, putative 0.0257 0.0812 0.2761
Plasmodium falciparum serine/threonine protein kinase KIN 0.0168 0.0377 0.2576
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0168 0.0377 0.2201
Giardia lamblia Kinase, AGC PKA 0.0348 0.1252 0.8546
Echinococcus multilocularis serine:threonine protein kinase N2 0.0655 0.2744 0.5472
Trypanosoma brucei protein kinase, putative 0.0121 0.0152 0.0295
Schistosoma mansoni atypical protein kinase C 0.0649 0.2714 0.5467
Echinococcus granulosus dual specificity 0.0186 0.0465 0.0895
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0284 0.0941 0.629
Echinococcus multilocularis c src tyrosine kinase 0.0156 0.0321 0.0641
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0292 0.098 0.1887
Loa Loa (eye worm) AGC/PKA protein kinase 0.0202 0.0542 0.0542
Echinococcus granulosus casein kinase I alpha 0.0238 0.0718 0.1382
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.0708 0.3001 0.3001
Schistosoma mansoni tyrosine kinase 0.0256 0.0806 0.1624
Trichomonas vaginalis CAMK family protein kinase 0.0389 0.1453 0.518
Echinococcus granulosus dual specificity protein kinase clk2 0.0341 0.1219 0.2346
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0787 0.3383 0.651
Schistosoma mansoni acetyl-CoA carboxylase 0.0193 0.0499 0.1004
Trichomonas vaginalis CAMK family protein kinase 0.0389 0.1453 0.518
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0521 0.2093 0.2093
Brugia malayi map kinase activated protein kinase protein 2 0.0893 0.3899 0.3895
Trypanosoma brucei protein kinase, putative 0.0284 0.0941 0.3244
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.0257 0.081 0.1616
Loa Loa (eye worm) hypothetical protein 0.0103 0.0065 0.0065
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0348 0.1252 0.2498
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0459 0.1792 0.3449
Brugia malayi Homeodomain interacting protein kinase protein 1 0.0257 0.081 0.0805
Echinococcus multilocularis tyrosine protein kinase Abl 0.0156 0.0321 0.0641
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.0183 0.0451 0.1412
Trichomonas vaginalis CMGC family protein kinase 0.0186 0.0465 0.1507
Loa Loa (eye worm) hypothetical protein 0.0156 0.0321 0.0321
Plasmodium falciparum glycogen synthase kinase 3 0.0284 0.0941 0.736
Brugia malayi Furin-like cysteine rich region family protein 0.1112 0.4964 0.4961
Brugia malayi Cam kinase protein 1 0.022 0.0631 0.0625
Toxoplasma gondii CMGC kinase, CK2 family 0.0218 0.0623 0.2113
Loa Loa (eye worm) TK/ABL protein kinase 0.0113 0.0111 0.0111
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0893 0.3899 0.7775
Entamoeba histolytica protein kinase, putative 0.0186 0.0465 0.1467
Loa Loa (eye worm) hypothetical protein 0.0257 0.0809 0.0809
Entamoeba histolytica PH domain containing protein kinase, putative 0.0363 0.1325 0.4678
Entamoeba histolytica protein kinase, putative 0.0136 0.0224 0.0566
Trichomonas vaginalis CAMK family protein kinase 0.017 0.039 0.1226
Schistosoma mansoni protein kinase 0.0984 0.4341 0.8746
Schistosoma mansoni serine/threonine protein kinase 0.0358 0.13 0.2618
Schistosoma mansoni serine/threonine protein kinase 0.0498 0.1983 0.3995
Entamoeba histolytica protein kinase domain containing protein 0.0121 0.0152 0.0295
Brugia malayi Protein kinase domain containing protein 0.0309 0.1065 0.1059
Echinococcus multilocularis epidermal growth factor receptor 0.0715 0.3035 0.6053
Brugia malayi putative serine/threonine kinase SADA gamma 0.0168 0.0377 0.0371
Plasmodium falciparum biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.0139 0.024 0.1418
Loa Loa (eye worm) TK/FER protein kinase 0.0261 0.0828 0.0828
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0158 0.0331 0.0331
Toxoplasma gondii AGC kinase 0.0202 0.0542 0.18
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0257 0.0812 0.1619
Loa Loa (eye worm) hypothetical protein 0.0106 0.0079 0.0079
Toxoplasma gondii AGC kinase 0.0641 0.2677 1
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0257 0.0812 0.2761
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0797 0.3435 0.3431
Echinococcus granulosus serine:threonine kinase SAD 1 0.0168 0.0377 0.0725
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.0186 0.0465 0.0465
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0181 0.044 0.044
Trypanosoma brucei rac serine-threonine kinase, putative 0.0656 0.275 1
Plasmodium vivax biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.0139 0.024 0.1418
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0277 0.0908 0.0903
Trypanosoma brucei cdc2-related kinase 1 0.0261 0.0831 0.2833
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0348 0.1252 0.8546
Echinococcus multilocularis RNA directed DNA polymerase 0.0091 0.0004 0.0009
Giardia lamblia Kinase, CK1 Casein kinase 0.0238 0.0718 0.4675
Schistosoma mansoni serine/threonine protein kinase 0.0269 0.0869 0.1751
Echinococcus granulosus tyrosine protein kinase Fyn 0.0256 0.0806 0.1552
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0091 0.0004 0.0009
Echinococcus granulosus tyrosine kinase 0.0113 0.0111 0.0213
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0202 0.0542 0.1751
Trypanosoma cruzi casein kinase, putative 0.0238 0.0718 0.4675
Echinococcus granulosus cGMP dependent protein kinase 1 0.018 0.0435 0.0838
Loa Loa (eye worm) carboxyl transferase domain-containing protein 0.0186 0.0466 0.0466
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0204 0.0555 0.0555
Loa Loa (eye worm) hypothetical protein 0.0103 0.0065 0.0065
Trichomonas vaginalis AGC family protein kinase 0.0358 0.13 0.4608
Schistosoma mansoni protein kinase 0.0499 0.1988 0.4005
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0202 0.0542 0.3974
Loa Loa (eye worm) TK protein kinase 0.0157 0.0325 0.0325
Onchocerca volvulus 0.0735 0.3129 0.911
Trichomonas vaginalis AGC family protein kinase 0.0381 0.1412 0.5028
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0261 0.0831 0.1599
Leishmania major protein kinase, putative 0.0183 0.0451 0.2738
Trichomonas vaginalis CMGC family protein kinase 0.0129 0.0188 0.0476
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0137 0.0229 0.0442
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0363 0.1325 0.9071
Trypanosoma brucei SNF1-related protein kinases, putative 0.0168 0.0377 0.1135
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.049 0.1944 0.3876
Brugia malayi Kinase associated domain 1 family protein 0.0152 0.03 0.0294
Entamoeba histolytica protein kinase, putative 0.0157 0.0325 0.0941
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0114 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.0106 0.0077 0.0077
Trichomonas vaginalis CAMK family protein kinase 0.0158 0.0328 0.0995
Brugia malayi Protein kinase domain containing protein 0.0424 0.1623 0.1618
Echinococcus multilocularis titin 0.0107 0.0082 0.0163
Schistosoma mansoni serine/threonine protein kinase 0.0797 0.3435 0.692
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0121 0.0152 0.0572
Plasmodium vivax protein kinase Crk2 0.0261 0.0831 0.6429
Echinococcus multilocularis NCK adaptor protein 0.0101 0.0055 0.0111
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0261 0.0831 0.0831
Brugia malayi Protein kinase domain containing protein 0.0113 0.0111 0.0105
Plasmodium falciparum protein kinase, putative 0.0121 0.0152 0.067
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0354 0.128 0.8747
Leishmania major acetyl-CoA carboxylase, putative 0.0193 0.0499 0.3085
Brugia malayi Protein kinase domain containing protein 0.0129 0.0188 0.0182
Schistosoma mansoni growth factor receptor-bound protein 0.0099 0.0044 0.0089
Schistosoma mansoni serine/threonine-protein kinase 0.0363 0.1325 0.2669
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0256 0.0806 0.1608
Trypanosoma brucei protein kinase, putative 0.0181 0.044 0.1374
Schistosoma mansoni protein kinase 0.0121 0.0152 0.0306
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.0498 0.1983 0.1983
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0801 0.3454 0.6647
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0715 0.3035 0.5841
Giardia lamblia Kinase, CMGC CK2 0.0218 0.0623 0.3985
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0284 0.0941 0.1811
Echinococcus multilocularis Immunoglobulin 0.0106 0.0077 0.0153
Echinococcus granulosus tyrosine protein kinase Fyn 0.0256 0.0806 0.1552
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.0116 0.0235
Echinococcus granulosus activin receptor type 0.0121 0.0152 0.0292
Loa Loa (eye worm) hypothetical protein 0.0257 0.0809 0.0809
Echinococcus multilocularis twitchin 0.0095 0.0022 0.0044
Loa Loa (eye worm) AUR protein kinase 0.0257 0.0812 0.0812
Schistosoma mansoni growth factor receptor-bound protein 0.0101 0.0055 0.0112
Echinococcus granulosus tyrosine protein kinase Srms 0.0576 0.2359 0.454
Toxoplasma gondii acetyl-CoA carboxylase ACC1 0.0193 0.0499 0.1635
Schistosoma mansoni serine/threonine kinase 0.0358 0.13 0.2618
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0218 0.0623 0.4664
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.022 0.0631 0.1258
Echinococcus multilocularis nervana 2 0.0284 0.094 0.1875
Onchocerca volvulus 0.0113 0.0111 0.0323
Schistosoma mansoni serine/threonine protein kinase 0.0595 0.2451 0.4939
Trichomonas vaginalis AGC family protein kinase 0.0656 0.275 1
Echinococcus multilocularis roundabout 2 0.0169 0.0381 0.076
Entamoeba histolytica protein kinase, putative 0.0656 0.275 1
Trichomonas vaginalis CMGC family protein kinase 0.0181 0.044 0.1414
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.022 0.0631 0.0625
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.022 0.0631 0.0631
Loa Loa (eye worm) AGC/PKA protein kinase 0.0202 0.0542 0.0542
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0073 0.0047
Loa Loa (eye worm) hypothetical protein 0.0406 0.1532 0.1532
Schistosoma mansoni serine/threonine protein kinase 0.0449 0.1744 0.3514
Brugia malayi Egg laying defective protein 4 0.018 0.0435 0.043
Trypanosoma brucei acetyl-CoA carboxylase 0.0193 0.0499 0.1591
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0301 0.1024 0.8066
Entamoeba histolytica PH domain containing protein kinase, putative 0.0363 0.1325 0.4678
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0113 0.0111 0.0143
Brugia malayi Protein kinase domain containing protein 0.0113 0.0111 0.0105
Schistosoma mansoni protein kinase 0.0984 0.4341 0.8746
Schistosoma mansoni protein kinase 0.0257 0.0812 0.1635
Trichomonas vaginalis CAMK family protein kinase 0.0389 0.1453 0.518
Plasmodium falciparum tyrosine kinase-like protein, putative 0.0174 0.041 0.286
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0356 0.1292 0.2487
Schistosoma mansoni serine/threonine protein kinase 0.0144 0.0263 0.0529
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.022 0.0631 0.0631
Brugia malayi Protein kinase domain containing protein 0.0708 0.3001 0.2997
Echinococcus multilocularis raf serine:threonine protein kinase 0.0144 0.0263 0.0524
Echinococcus granulosus casein kinase I delta 0.0238 0.0718 0.1382
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.022 0.0631 0.2086
Schistosoma mansoni serine/threonine protein kinase 0.1083 0.4821 0.9712
Echinococcus granulosus mitogen activated protein kinase 11 0.0354 0.128 0.2464
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0228 0.0668 0.1333
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0269 0.0869 0.0869
Trichomonas vaginalis AGC family protein kinase 0.0301 0.1024 0.3585
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0595 0.2451 0.4888
Schistosoma mansoni ste20-related kinase 0.0459 0.1793 0.3612
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0099 0.0044 0.0044
Echinococcus granulosus tyrosine protein kinase 0.0329 0.1162 0.2236
Echinococcus multilocularis N chimaerin 0.0143 0.0257 0.0513
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0176 0.0415 0.0415
Loa Loa (eye worm) TK/FER protein kinase 0.0113 0.0111 0.0111
Brugia malayi Protein kinase domain containing protein 0.0708 0.3001 0.2997
Echinococcus multilocularis protein kinase c epsilon type 0.0448 0.1737 0.3463
Trypanosoma cruzi polo-like protein kinase, putative 0.0389 0.1453 1
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0228 0.0668 0.4316
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0202 0.0542 0.0536
Schistosoma mansoni hypothetical protein 0.0228 0.0668 0.1347
Schistosoma mansoni serine/threonine protein kinase 0.018 0.0435 0.0877
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0107 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0205 0.0557 0.0557
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0356 0.1292 0.2577
Echinococcus granulosus cGMP dependent protein kinase 0.018 0.0435 0.0838
Trichomonas vaginalis CAMK family protein kinase 0.0204 0.0555 0.1841
Echinococcus multilocularis mitogen activated protein kinase 11 0.0354 0.128 0.2553
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0893 0.3899 0.7503
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0228 0.0668 0.4316
Schistosoma mansoni serine/threonine protein kinase 0.0655 0.2744 0.5528
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0764 0.3273 0.3273
Entamoeba histolytica protein kinase, putative 0.0257 0.0812 0.2761
Leishmania major protein kinase, putative 0.0341 0.1219 0.8305
Onchocerca volvulus Tyrosine kinase homolog 0.0607 0.2509 0.7303
Loa Loa (eye worm) hypothetical protein 0.0708 0.3001 0.3001
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0397 0.149 0.2972
Echinococcus multilocularis rac serine:threonine kinase 0.0363 0.1325 0.2642
Echinococcus granulosus casein kinase i 0.0238 0.0718 0.1382
Echinococcus multilocularis serine:threonine protein kinase 3 0.0578 0.2369 0.4723
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0797 0.3435 0.3435
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0321 0.1121 0.2157
Onchocerca volvulus 0.0107 0.0082 0.0238
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0228 0.0668 0.2226
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0257 0.0812 0.2761
Echinococcus multilocularis epidermal growth factor receptor 0.1112 0.4964 0.9899
Echinococcus multilocularis cyclin dependent kinase 5 0.0261 0.0831 0.1657
Schistosoma mansoni serine/threonine protein kinase 0.0176 0.0415 0.0837
Schistosoma mansoni protein kinase 0.0984 0.4341 0.8746
Echinococcus multilocularis casein kinase I alpha 0.0238 0.0718 0.1432
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.0708 0.3001 0.3001
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.049 0.1944 0.374
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0261 0.0831 0.5494
Onchocerca volvulus 0.0359 0.1305 0.3799
Onchocerca volvulus 0.0129 0.0188 0.0547
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0137 0.0229 0.0458
Brugia malayi Immunoglobulin I-set domain containing protein 0.0118 0.0137 0.0131
Onchocerca volvulus 0.0238 0.0718 0.209
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0168 0.0377 0.1135
Brugia malayi Immunoglobulin I-set domain containing protein 0.0427 0.1638 0.1633
Loa Loa (eye worm) hypothetical protein 0.0152 0.03 0.03
Trichomonas vaginalis CMGC family protein kinase 0.0186 0.0465 0.1507
Echinococcus granulosus cyclin dependent kinase 0.0261 0.0831 0.1599
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0183 0.0451 0.2738
Echinococcus multilocularis aurora kinase A 0.0257 0.0812 0.1619
Brugia malayi MAP kinase sur-1 0.0181 0.044 0.0435
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0143 0.0257 0.0518
Echinococcus multilocularis casein kinase I alpha 0.0238 0.0718 0.1432
Echinococcus multilocularis casein kinase I gamma 0.0478 0.1883 0.3755
Giardia lamblia Kinase, CMGC SRPK 0.0179 0.0433 0.2613
Loa Loa (eye worm) hypothetical protein 0.0204 0.0555 0.0555
Schistosoma mansoni tyrosine kinase 0.0156 0.0321 0.0647
Trichomonas vaginalis AGC family protein kinase 0.0656 0.275 1
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0358 0.13 0.2591
Schistosoma mansoni tyrosine kinase 0.0658 0.2758 0.5557
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0284 0.0941 0.1896
Schistosoma mansoni serine/threonine protein kinase 0.0202 0.0542 0.1091
Trichomonas vaginalis AGC family protein kinase 0.0176 0.0415 0.1321
Trichomonas vaginalis CAMK family protein kinase 0.0309 0.1065 0.3736
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0354 0.128 0.8747
Echinococcus granulosus dual specificity 0.0186 0.0465 0.0895
Brugia malayi Protein kinase domain containing protein 0.1018 0.4504 0.4501
Entamoeba histolytica protein kinase, putative 0.0641 0.2677 0.9729
Loa Loa (eye worm) hypothetical protein 0.0202 0.0542 0.0542
Brugia malayi Hr1 repeat family protein 0.0655 0.2744 0.2739
Schistosoma mansoni serine/threonine protein kinase 0.0358 0.13 0.2618
Schistosoma mansoni rap gtpase-activating protein 0.0228 0.0668 0.1347
Entamoeba histolytica protein kinase, putative 0.0179 0.0433 0.1348
Schistosoma mansoni serine/threonine protein kinase 0.0735 0.3129 0.6305
Trichomonas vaginalis CAMK family protein kinase 0.0168 0.0377 0.1177
Echinococcus multilocularis serine:threonine protein kinase N2 0.0297 0.1007 0.2008
Brugia malayi Fibronectin type III domain containing protein 0.0118 0.0137 0.0131
Schistosoma mansoni serine/threonine-protein kinase 0.0363 0.1325 0.2669
Loa Loa (eye worm) AGC/AKT protein kinase 0.0656 0.275 0.275
Leishmania major protein kinase, putative 0.022 0.0631 0.4044
Loa Loa (eye worm) hypothetical protein 0.0228 0.0668 0.0668
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0257 0.0812 0.1562
Echinococcus granulosus epidermal growth factor receptor 0.0715 0.3035 0.5841
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0261 0.0831 0.2912
Loa Loa (eye worm) hypothetical protein 0.0122 0.0154 0.0154
Brugia malayi p21/Cdc42/Rac1-activated kinase 0.0114 0.0116 0.0111
Schistosoma mansoni serine/threonine protein kinase 0.0448 0.1737 0.3499
Trichomonas vaginalis AGC family protein kinase 0.0381 0.1412 0.5028
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.0022 0.0044
Echinococcus granulosus serine:threonine protein kinase 0.0204 0.0555 0.1068
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0256 0.0806 0.1608
Loa Loa (eye worm) hypothetical protein 0.0126 0.0174 0.0174
Brugia malayi serine/threonine protein kinase 6 0.0257 0.0812 0.0806
Brugia malayi protein kinase C II. 0.0448 0.1737 0.1732
Echinococcus multilocularis cGMP dependent protein kinase 1 0.018 0.0435 0.0868
Brugia malayi Protein kinase domain containing protein 0.0478 0.1883 0.1878
Trypanosoma cruzi aurora B kinase, putative 0.0257 0.0812 0.5354
Schistosoma mansoni protein kinase 0.0218 0.0623 0.1255
Echinococcus multilocularis growth factor receptor bound protein 2 0.0099 0.0044 0.0089
Loa Loa (eye worm) TK protein kinase 0.0329 0.1162 0.1162
Brugia malayi Doublecortin family protein 0.0335 0.1188 0.1182
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0408 0.1545 0.1545
Brugia malayi cell division control protein 2 homolog 0.0261 0.0831 0.0826
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0238 0.0718 0.4675
Schistosoma mansoni serine/threonine protein kinase 0.0172 0.0399 0.0804
Trichomonas vaginalis CAMK family protein kinase 0.0168 0.0377 0.1177
Loa Loa (eye worm) AUR protein kinase 0.0257 0.0812 0.0812
Loa Loa (eye worm) hypothetical protein 0.0168 0.0377 0.0377
Schistosoma mansoni protein kinase 0.0121 0.0152 0.0306
Trichomonas vaginalis CK1 family protein kinase 0.0238 0.0718 0.2446
Trichomonas vaginalis CAMK family protein kinase 0.0168 0.0377 0.1177
Brugia malayi Protein kinase domain containing protein 0.0131 0.0197 0.0191
Trichomonas vaginalis AGC family protein kinase 0.0656 0.275 1
Schistosoma mansoni serine/threonine protein kinase 0.0216 0.0612 0.1233
Brugia malayi protein-tyrosine kinase 0.0213 0.0596 0.059
Echinococcus granulosus serine:threonine protein kinase N2 0.0655 0.2744 0.528
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0202 0.0542 0.3396
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0143 0.0257 0.0518
Schistosoma mansoni serine/threonine protein kinase 0.0261 0.0831 0.1674
Echinococcus multilocularis serine:threonine protein kinase 0.0204 0.0555 0.1107
Entamoeba histolytica protein kinase, putative 0.0151 0.0297 0.0837
Echinococcus multilocularis PAK box P21 Rho binding 0.0136 0.0224 0.0447
Echinococcus granulosus tyrosine protein kinase HCK 0.0157 0.0325 0.0625
Trichomonas vaginalis CAMK family protein kinase 0.0168 0.0377 0.1177
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0256 0.0806 0.1608
Entamoeba histolytica serine/threonine protein kinase, putative 0.0389 0.1453 0.5157
Schistosoma mansoni protein kinase 0.0186 0.0466 0.0938
Entamoeba histolytica cell division protein kinase 2, putative 0.0261 0.0831 0.2833
Echinococcus multilocularis phosphorylase kinase gamma subunit 0.0365 0.1335 0.2663
Echinococcus granulosus mitogen activated protein kinase 0.0181 0.044 0.0848
Echinococcus granulosus Protein kinase C brain isozyme 0.0539 0.2178 0.4192
Schistosoma mansoni tyrosine kinase 0.0774 0.3323 0.6695
Trichomonas vaginalis CK1 family protein kinase 0.0238 0.0718 0.2446
Trichomonas vaginalis CMGC family protein kinase 0.0129 0.0188 0.0476
Trichomonas vaginalis CAMK family protein kinase 0.0389 0.1453 0.518
Echinococcus multilocularis 0.0325 0.1139 0.2272
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0228 0.0668 0.1347
Schistosoma mansoni tyrosine kinase 0.0715 0.3035 0.6115
Trichomonas vaginalis CMGC family protein kinase 0.0186 0.0465 0.1507
Trichomonas vaginalis CMGC family protein kinase 0.0218 0.0623 0.2092
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0238 0.0718 0.0718
Trichomonas vaginalis CAMK family protein kinase 0.0168 0.0377 0.1177
Echinococcus multilocularis tyrosine kinase 0.0113 0.0111 0.0221
Onchocerca volvulus 0.0129 0.0188 0.0547
Onchocerca volvulus Netrin receptor homolog 0.0097 0.0032 0.0093
Schistosoma mansoni tyrosine kinase 0.0658 0.2758 0.5557
Loa Loa (eye worm) SRC-1 0.0256 0.0806 0.0806
Schistosoma mansoni protein kinase 0.0121 0.0152 0.0306
Trichomonas vaginalis CAMK family protein kinase 0.0168 0.0377 0.1177
Loa Loa (eye worm) hypothetical protein 0.0272 0.0885 0.0885
Plasmodium vivax casein kinase 1, putative 0.0238 0.0718 0.5471
Trichomonas vaginalis CMGC family protein kinase 0.0284 0.0941 0.3275
Trichomonas vaginalis STE family protein kinase 0.0105 0.0073 0.0047
Onchocerca volvulus 0.0113 0.0111 0.0323
Echinococcus multilocularis myosin iiia 0.0183 0.0451 0.0899
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0397 0.149 0.2868
Echinococcus granulosus titin 0.0107 0.0082 0.0158
Loa Loa (eye worm) hypothetical protein 0.0099 0.0044 0.0044
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0256 0.0806 0.1552
Brugia malayi Fes/CIP4 homology domain containing protein 0.0213 0.0595 0.059
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.022 0.0631 0.2144
Brugia malayi Protein kinase domain containing protein 0.0774 0.3323 0.3319
Echinococcus granulosus defective proboscis extension response 0.0106 0.0077 0.0148
Schistosoma mansoni tyrosine kinase 0.0715 0.3035 0.6115
Loa Loa (eye worm) thyroid receptor interactor 0.0213 0.0595 0.0595
Plasmodium falciparum serine/threonine protein kinase 0.0179 0.0433 0.3058
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0641 0.2677 0.2677
Entamoeba histolytica protein kinase, putative 0.0107 0.0084 0.0041
Onchocerca volvulus Serine\/threonine kinase homolog 0.0365 0.1335 0.3888
Trichomonas vaginalis CMGC family protein kinase 0.0341 0.1219 0.4309
Loa Loa (eye worm) hypothetical protein 0.0359 0.1305 0.1305
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0106 0.0077 0.0153
Loa Loa (eye worm) TK/FER protein kinase 0.0113 0.0111 0.0111
Trichomonas vaginalis STE family protein kinase 0.0186 0.0466 0.1509
Trichomonas vaginalis AGC family protein kinase 0.0656 0.275 1
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0186 0.0466 0.0929
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0073 0.0047
Trichomonas vaginalis CMGC family protein kinase 0.0181 0.044 0.1414
Onchocerca volvulus 0.0113 0.0111 0.0323
Echinococcus granulosus mitogen activated protein kinase 14 0.0354 0.128 0.2464
Schistosoma mansoni protein kinase 0.0272 0.0882 0.1777
Brugia malayi STE20-like kinase MST 0.0578 0.2369 0.2364
Trichomonas vaginalis AGC family protein kinase 0.0656 0.275 1
Schistosoma mansoni tyrosine kinase 0.0355 0.1288 0.2595
Plasmodium vivax unspecified product 0.0218 0.0623 0.4664
Brugia malayi hypothetical protein 0.0498 0.1983 0.1978
Echinococcus granulosus tyrosine protein kinase Lyn 0.032 0.1118 0.2152
Trichomonas vaginalis CAMK family protein kinase 0.0158 0.0328 0.0995
Toxoplasma gondii aurora kinase 0.0257 0.0812 0.2838
Entamoeba histolytica protein kinase, putative 0.0358 0.13 0.4583
Trichomonas vaginalis AGC family protein kinase 0.0176 0.0415 0.1321
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0269 0.0869 0.2976
Echinococcus granulosus titin 0.0107 0.0082 0.0158
Echinococcus granulosus tyrosine protein kinase Src64B 0.0256 0.0806 0.1552
Echinococcus multilocularis myotubularin protein 13 0.0102 0.0058 0.0117
Giardia lamblia Kinase, NEK 0.0301 0.1024 0.6893
Brugia malayi Protein kinase domain containing protein 0.0797 0.3435 0.3431
Giardia lamblia Kinase, PLK 0.0389 0.1453 1
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0143 0.0257 0.0257
Onchocerca volvulus 0.0108 0.0085 0.0248
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0186 0.0465 0.2844
Echinococcus granulosus Vam6:Vps39 protein 0.0228 0.0668 0.1286
Brugia malayi hypothetical protein 0.0103 0.0065 0.0059
Loa Loa (eye worm) TK/FER protein kinase 0.0113 0.0111 0.0111
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0348 0.1252 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 5.8584 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 79.4328 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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