Detailed information for compound 1375515

Basic information

Technical information
  • TDR Targets ID: 1375515
  • Name: N-(1-adamantyl)-2-pyrrolidin-1-ylacetamide hy drochloride
  • MW: 298.851 | Formula: C16H27ClN2O
  • H donors: 1 H acceptors: 1 LogP: 3.57 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NC12CC3CC(C2)CC(C1)C3)CN1CCCC1.Cl
  • InChi: 1S/C16H26N2O.ClH/c19-15(11-18-3-1-2-4-18)17-16-8-12-5-13(9-16)7-14(6-12)10-16;/h12-14H,1-11H2,(H,17,19);1H
  • InChiKey: RFKDBVNSJASBKF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(1-adamantyl)-2-pyrrolidin-1-yl-acetamide hydrochloride
  • N-(1-adamantyl)-2-1-pyrrolidinylacetamide hydrochloride
  • N-(1-adamantyl)-2-pyrrolidin-1-yl-ethanamide hydrochloride
  • 25517-09-3
  • MLS000666631
  • N-1-adamantyl-2-(1-pyrrolidinyl)acetamide hydrochloride
  • SMR000268301
  • 1-Pyrrolidineacetamide, N-(1-adamantyl)-, HCl
  • 1-Pyrrolidineacetamide, N-1-adamantyl-, monohydrochloride
  • N-1-Adamantyl-1-pyrrolidineacetamide monohydrochloride
  • T 2239

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica cysteine protease, putative 0.0588 0.1893 0.5445
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.0289 0.0288
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0071 0.007
Mycobacterium leprae putative cytochrome p450 0.0032 0.0054 0.169
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0032 0.0054 0.0483
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0049 0.0048
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.0255 0.0254
Giardia lamblia Cathepsin B precursor 0.0266 0.0827 0.2205
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0054 0.0107
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0092 0.0927
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1061 0.3456 0.943
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0024 0.0024
Trypanosoma cruzi cysteine peptidase, putative 0.1061 0.3456 0.3456
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0071 0.007
Trypanosoma cruzi cysteine peptidase, putative 0.1061 0.3456 0.3456
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0054 0.0107
Mycobacterium tuberculosis Probable oxidoreductase 0.0093 0.0256 0.2856
Schistosoma mansoni glucose transport protein 0.0103 0.0289 0.0289
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0024 0.0023
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.019 0.019
Entamoeba histolytica cysteine proteinase, putative 0.0588 0.1893 0.5445
Leishmania major glucose transporter, lmgt2 0.0032 0.0054 0.0146
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0167 0.05 0.1341
Schistosoma mansoni cathepsin C 0.0266 0.0827 0.0827
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0098 0.0272 0.0271
Trypanosoma cruzi polo-like protein kinase, putative 0.0098 0.0272 0.0272
Onchocerca volvulus Cathepsin L homolog 0.0266 0.0827 0.2367
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0115 0.0327 0.0327
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0049 0.0049
Schistosoma mansoni glutaminase 0.0434 0.1382 0.1382
Trypanosoma brucei polo-like protein kinase 0.0098 0.0272 0.0741
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0077 0.0204 0.0203
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0111 0.0265
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.019 0.019
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.005 0.0097
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0049 0.0048
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0738 0.239 0.239
Entamoeba histolytica cysteine proteinase, putative 0.1061 0.3456 1
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0049 0.0049
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0186 0.0564 0.0563
Giardia lamblia Cathepsin B precursor 0.1124 0.3664 1
Brugia malayi steroid hormone receptor 0.0031 0.0049 0.0048
Loa Loa (eye worm) hypothetical protein 0.0738 0.239 0.2389
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0049 0.0048
Loa Loa (eye worm) hypothetical protein 0.0266 0.0827 0.0826
Plasmodium vivax unspecified product 0.0322 0.1014 0.291
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0131 0.013
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0049 0.0109
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0032 0.0054 0.0147
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0006 0.0006
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.0053 0.0146
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0979 0.2644
Mycobacterium ulcerans lipase LipD 0.0043 0.0092 0.0498
Schistosoma mansoni hypothetical protein 0.0016 0.0001 0.0001
Mycobacterium ulcerans beta-lactamase 0.0043 0.0092 0.0498
Giardia lamblia PHD finger protein 15 0.0028 0.0042 0.0049
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0588 0.1893 0.5166
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0053 0.0052
Brugia malayi Cathepsin L-like precursor 0.1061 0.3456 0.3455
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.0661 0.1772
Trypanosoma cruzi major cysteine proteinase, putative 0.0266 0.0827 0.0827
Plasmodium vivax hexose transporter 0.0103 0.0289 0.0806
Onchocerca volvulus Cathepsin L homolog 0.1061 0.3456 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0049 0.0048
Onchocerca volvulus 0.1061 0.3456 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0084 0.0225 0.2494
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0054 0.0054
Loa Loa (eye worm) cytochrome P450 family protein 0.0088 0.024 0.0239
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0312 0.0979 0.0979
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0312 0.0979 0.0979
Brugia malayi cathepsin F-like cysteine proteinase 0.0266 0.0827 0.0826
Brugia malayi Pre-SET motif family protein 0.006 0.0146 0.0145
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0042 0.0041
Trypanosoma cruzi major cysteine proteinase, putative 0.0266 0.0827 0.0827
Loa Loa (eye worm) hypothetical protein 0.0043 0.0092 0.0091
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0625 0.1672
Brugia malayi Cytochrome P450 family protein 0.0032 0.0054 0.0053
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.005 0.0072
Brugia malayi beta-lactamase 0.0043 0.0092 0.0091
Echinococcus multilocularis peregrin 0.0031 0.005 0.0049
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0139 0.0409 0.0408
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0032 0.0054 0.0219
Echinococcus multilocularis cathepsin b 0.3039 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1061 0.3456 0.943
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0098 0.0272 0.0741
Trichomonas vaginalis esterase, putative 0.0043 0.0092 0.0211
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0049 0.0109
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0266 0.0827 0.2225
Trypanosoma cruzi cytochrome P450, putative 0.0043 0.0089 0.0089
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0266 0.0827 0.2225
Toxoplasma gondii facilitative glucose transporter GT1 0.0103 0.0289 0.0764
Loa Loa (eye worm) hypothetical protein 0.0023 0.0024 0.0023
Schistosoma mansoni zinc finger protein 0.002 0.0015 0.0015
Entamoeba histolytica protein kinase, putative 0.0032 0.0053 0.0085
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1061 0.3456 0.943
Brugia malayi Cam kinase protein 1 0.0032 0.0053 0.0052
Loa Loa (eye worm) hypothetical protein 0.0031 0.0049 0.0048
Leishmania major cathepsin L-like protease 0.1061 0.3456 0.9433
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1061 0.3456 0.943
Loa Loa (eye worm) hypothetical protein 0.0073 0.0189 0.0188
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0067 0.0169 0.0169
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0046 0.0045
Brugia malayi jmjC domain containing protein 0.0093 0.0255 0.0254
Trypanosoma brucei glucose transporter, putative 0.0032 0.0054 0.0146
Schistosoma mansoni hypothetical protein 0.0021 0.0018 0.0018
Brugia malayi nuclear hormone receptor 0.0031 0.0049 0.0048
Leishmania major cathepsin L-like protease 0.1061 0.3456 0.9433
Plasmodium falciparum serine repeat antigen 1 0.0266 0.0827 0.2367
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0979 0.2644
Loa Loa (eye worm) cysteine protease 0.1061 0.3456 0.3455
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0738 0.239 0.2389
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.0053 0.0122
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0266 0.0827 0.2205
Schistosoma mansoni hypothetical protein 0.0035 0.0062 0.0062
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.0053 0.0122
Loa Loa (eye worm) cytochrome P450 0.0032 0.0054 0.0053
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0131 0.013
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0032 0.0054 0.0483
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0151 0.015
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.0289 0.0288
Mycobacterium ulcerans hypothetical protein 0.0043 0.0092 0.0498
Giardia lamblia Cathepsin L precursor 0.0266 0.0827 0.2205
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.0289 0.0288
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0186 0.0564 0.0563
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.005 0.0049
Trypanosoma cruzi cysteine protease, putative 0.0588 0.1893 0.1893
Onchocerca volvulus Alhambra homolog 0.0028 0.0042 0.0088
Toxoplasma gondii transporter, cation channel family protein 0.0026 0.0035 0.007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0588 0.1893 0.5166
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0049 0.0048
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.0867 1
Echinococcus granulosus zinc finger protein 0.002 0.0015 0.0014
Schistosoma mansoni hypothetical protein 0.0019 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0032 0.0053 0.0052
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0272 0.0704
Brugia malayi Cathepsin L-like precursor 0.1061 0.3456 0.3455
Onchocerca volvulus 0.0738 0.239 0.6905
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0054 0.0107
Onchocerca volvulus 0.006 0.0146 0.039
Giardia lamblia Cysteine protease 0.0266 0.0827 0.2205
Schistosoma mansoni polycystin 1-related 0.0019 0.0011 0.0011
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0032 0.0054 0.0219
Schistosoma mansoni hypothetical protein 0.0016 0.0001 0.0001
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0266 0.0827 0.0827
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0093 0.0256 0.2856
Giardia lamblia Kinase, PLK 0.0098 0.0272 0.068
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1061 0.3456 0.9433
Schistosoma mansoni hypothetical protein 0.0016 0.0001 0.0001
Onchocerca volvulus 0.1061 0.3456 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0049 0.0048
Entamoeba histolytica cysteine protease, putative 0.0266 0.0827 0.2339
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.019 0.2083
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0049 0.0048
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0032 0.0054 0.0483
Brugia malayi Papain family cysteine protease containing protein 0.0266 0.0827 0.0826
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.006 0.0146 0.0146
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.005 0.005
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0266 0.0827 0.2225
Echinococcus multilocularis cysteine protease 0.1061 0.3456 0.3455
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0078 0.0077
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0092 0.3245
Entamoeba histolytica cysteine protease, putative 0.0588 0.1893 0.5445
Entamoeba histolytica cysteine protease, putative 0.0588 0.1893 0.5445
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0049 0.0048
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.019 0.019
Schistosoma mansoni cathepsin s 0.0322 0.1014 0.1014
Schistosoma mansoni bromodomain containing protein 0.0065 0.0163 0.0163
Leishmania major cathepsin L-like protease 0.1061 0.3456 0.9433
Echinococcus multilocularis 0.0032 0.0054 0.0053
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0092 0.0233
Trichomonas vaginalis conserved hypothetical protein 0.0266 0.0827 0.2225
Echinococcus granulosus voltage dependent calcium channel 0.0026 0.0035 0.0034
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0266 0.0827 0.2225
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0054 0.0054
Onchocerca volvulus Cathepsin F homolog 0.1061 0.3456 1
Echinococcus granulosus cathepsin b 0.3039 1 1
Mycobacterium tuberculosis Conserved protein 0.0043 0.0092 0.0927
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0074 0.0366
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0266 0.0827 0.2225
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0054 0.0107
Trypanosoma cruzi hexose transporter 0.0032 0.0054 0.0054
Brugia malayi PHD-finger family protein 0.0026 0.0033 0.0032
Loa Loa (eye worm) voltage-dependent calcium channel 0.0026 0.0035 0.0034
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0084 0.0225 0.2494
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0588 0.1893 0.5146
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0266 0.0827 0.0827
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.0827 0.2225
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.0173 0.0472
Trypanosoma brucei cysteine peptidase C (CPC) 0.1124 0.3664 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0738 0.239 0.6509
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0322 0.1014 0.1013
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0032 0.0054 0.0483
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1061 0.3456 0.943
Loa Loa (eye worm) hypothetical protein 0.0266 0.0827 0.0826
Entamoeba histolytica cysteine proteinase, putative 0.0738 0.239 0.6894
Entamoeba histolytica hypothetical protein 0.0266 0.0827 0.2339
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.1124 0.3664 1
Brugia malayi Doublecortin family protein 0.0019 0.0011 0.001
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0049 0.0048
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0266 0.0827 0.2367
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.0173 0.0173
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0032 0.0054 0.0054
Brugia malayi Cathepsin L-like precursor 0.1061 0.3456 0.3455
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0093 0.0256 0.2856
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.3039 1 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.019 0.1225
Loa Loa (eye worm) hypothetical protein 0.0043 0.0092 0.0091
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0266 0.0827 0.2225
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1061 0.3456 0.943
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1061 0.3456 0.9433
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0266 0.0827 0.2205
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0092 0.0927
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0266 0.0827 0.0827
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1061 0.3456 0.943
Onchocerca volvulus 0.0474 0.1517 0.4371
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1061 0.3456 0.943
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.019 0.019
Trypanosoma cruzi cysteine peptidase, putative 0.1061 0.3456 0.3456
Plasmodium falciparum cysteine proteinase falcipain 3 0.1061 0.3456 1
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0024 0.0024
Entamoeba histolytica cysteine protease, putative 0.0588 0.1893 0.5445
Trypanosoma cruzi cytochrome P450, putative 0.0043 0.0089 0.0089
Brugia malayi ecdysteroid receptor 0.0031 0.0049 0.0048
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.001
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0008 0.0007
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0266 0.0827 0.2339
Loa Loa (eye worm) sugar transporter 0.0103 0.0289 0.0288
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0588 0.1893 0.1893
Loa Loa (eye worm) papain family cysteine protease containing protein 0.1061 0.3456 0.3455
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0049 0.0048
Loa Loa (eye worm) cathepsin B 0.1124 0.3664 0.3663
Brugia malayi Cytochrome P450 family protein 0.0043 0.0089 0.0088
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0266 0.0827 0.2205
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0053 0.0052
Onchocerca volvulus 0.0266 0.0827 0.2367
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0049 0.0048
Brugia malayi follicle stimulating hormone receptor 0.0225 0.0693 0.0692
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.0053 0.0122
Echinococcus granulosus cathepsin l1 0.1061 0.3456 0.3455
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0266 0.0827 0.2367
Onchocerca volvulus 0.1061 0.3456 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0042 0.0087
Loa Loa (eye worm) hypothetical protein 0.0035 0.0062 0.0061
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0049 0.0049
Brugia malayi Papain family cysteine protease containing protein 0.0588 0.1893 0.1892
Loa Loa (eye worm) beta-lactamase 0.0043 0.0092 0.0091
Mycobacterium leprae Conserved hypothetical protein 0.0032 0.0054 0.169
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0025 0.0024
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0054 0.0146
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0067 0.0169 0.0462
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0032 0.0054 0.0219
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.0272 0.0272
Loa Loa (eye worm) hypothetical protein 0.0031 0.0049 0.0048
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0049 0.0048
Trypanosoma cruzi cysteine peptidase, putative 0.1061 0.3456 0.3456
Brugia malayi beta-lactamase family protein 0.0043 0.0092 0.0091
Plasmodium falciparum cysteine proteinase falcipain 2b 0.1061 0.3456 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0266 0.0827 0.0827
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.0053 0.0122
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1061 0.3456 0.943
Giardia lamblia Cathepsin B precursor 0.1124 0.3664 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1061 0.3456 0.943
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0186 0.0564 0.0564
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0074 0.0201
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0074 0.0145
Plasmodium vivax serine-repeat antigen (SERA) 0.0266 0.0827 0.2367
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0032 0.0054 0.0219
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1061 0.3456 0.943
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0173 0.0173
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0173 0.0472
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0151 0.015
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.0661 0.1772
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0074 0.0074
Leishmania major cathepsin L-like protease 0.1061 0.3456 0.9433
Giardia lamblia Cysteine protease 0.0266 0.0827 0.2205
Echinococcus granulosus histone lysine methyltransferase setb 0.0077 0.0204 0.0203
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0049 0.0048
Loa Loa (eye worm) hypothetical protein 0.0322 0.1014 0.1013
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1124 0.3664 0.3664
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.0827 0.2225
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0032 0.0054 0.0483
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0266 0.0827 0.0826
Trypanosoma brucei glucose transporter, putative 0.0032 0.0054 0.0146
Trypanosoma cruzi cysteine proteinase, putative 0.0588 0.1893 0.1893
Trypanosoma cruzi cysteine peptidase, putative 0.0588 0.1893 0.1893
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0092 0.0927
Brugia malayi Bromodomain containing protein 0.0039 0.0078 0.0078
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0032 0.0054 0.0483
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0053 0.0052
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0049 0.0048
Onchocerca volvulus 0.1061 0.3456 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1061 0.3456 0.943
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0018 0.0017
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0266 0.0827 0.0826
Brugia malayi Papain family cysteine protease containing protein 0.0588 0.1893 0.1892
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1061 0.3456 0.943
Toxoplasma gondii cathepsin CPC1 0.0266 0.0827 0.2236
Brugia malayi beta-lactamase family protein 0.0043 0.0092 0.0091
Plasmodium falciparum hexose transporter 0.0103 0.0289 0.0806
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0266 0.0827 0.2225
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0092 0.025
Echinococcus granulosus cathepsin b 0.3039 1 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0092 0.0211
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0024 0.0065
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1061 0.3456 0.943
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0078 0.0078
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0025 0.0024
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1061 0.3456 0.3455
Loa Loa (eye worm) hypothetical protein 0.0043 0.0092 0.0091
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0266 0.0827 0.2367
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0062 0.0061
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0053 0.0052
Giardia lamblia Cathepsin L precursor 0.0266 0.0827 0.2205
Brugia malayi jmjC domain containing protein 0.0036 0.0068 0.0067
Echinococcus granulosus cytochrome P450 2K1 0.0032 0.0054 0.0053
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0043 0.0089 0.0477
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0054 0.0146
Loa Loa (eye worm) cytochrome P450 family protein 0.0043 0.0089 0.0088
Trichomonas vaginalis glutaminase, putative 0.0434 0.1382 0.3748
Entamoeba histolytica cysteine protease, putative 0.0588 0.1893 0.5445
Leishmania major cathepsin L-like protease 0.1061 0.3456 0.9433
Schistosoma mansoni coup transcription factor 0.0031 0.0049 0.0049
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1061 0.3456 0.943
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.0146 0.0145
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0006 0.0006
Brugia malayi Bromodomain containing protein 0.0031 0.005 0.0049
Leishmania major hypothetical protein, conserved 0.0043 0.0092 0.025
Plasmodium vivax glutathione reductase, putative 0.0037 0.007 0.0169
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0032 0.0054 0.0483
Leishmania major cysteine peptidase A (CPA) 0.1061 0.3456 0.9433
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0092 0.0092
Brugia malayi cathepsin Z-like cysteine proteinase 0.0266 0.0827 0.0826
Schistosoma mansoni rab6-interacting 0.0019 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0322 0.1014 0.1013
Trypanosoma brucei cytochrome P450, putative 0.0043 0.0089 0.0242
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1061 0.3456 0.9433
Leishmania major cathepsin L-like protease 0.1061 0.3456 0.9433
Trypanosoma brucei glucose transporter 1E 0.0032 0.0054 0.0146
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0979 0.2644
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0272 0.0704
Trypanosoma brucei trypanothione reductase 0.0037 0.007 0.019
Onchocerca volvulus Huntingtin homolog 0.0063 0.0155 0.0418
Echinococcus granulosus cathepsin L cysteine protease 0.0588 0.1893 0.1892
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.0053 0.0122
Onchocerca volvulus Glucosylceramidase homolog 0.0205 0.0625 0.1781
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0111 0.0265
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0139 0.0409 0.0408
Loa Loa (eye worm) hypothetical protein 0.0031 0.0049 0.0048
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0032 0.0054 0.0054
Toxoplasma gondii cytochrome p450 superfamily protein 0.0032 0.0054 0.012
Entamoeba histolytica cysteine protease, putative 0.1061 0.3456 1
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0032 0.0054 0.0219
Giardia lamblia Cathepsin B precursor 0.0266 0.0827 0.2205
Brugia malayi fibroinase precursor 0.0266 0.0827 0.0826
Plasmodium falciparum protein kinase 7 0.0292 0.0912 0.2616
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0049 0.0049
Echinococcus granulosus cathepsin L cysteine proteinase 0.1061 0.3456 0.3455
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0067 0.0067
Schistosoma mansoni cathepsin F (C01 family) 0.1061 0.3456 0.3456
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0092 0.0091
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1061 0.3456 0.943
Giardia lamblia Cathepsin L-like protease 0.0266 0.0827 0.2205
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0092 0.0211
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0032 0.0054 0.0483
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1061 0.3456 0.9433
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0024 0.0037
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0417 0.1326 0.1326
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0266 0.0827 0.2225
Onchocerca volvulus Huntingtin homolog 0.0063 0.0155 0.0418
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0123 0.0356 0.0356
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0049 0.0048
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0266 0.0827 0.2367
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0084 0.0225 0.873
Brugia malayi Cathepsin L-like precursor 0.0738 0.239 0.2389
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0046 0.0045
Plasmodium falciparum serine repeat antigen 7 0.0266 0.0827 0.2367
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0074 0.5
Schistosoma mansoni cathepsin S (C01 family) 0.0266 0.0827 0.0827
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1061 0.3456 0.943
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1061 0.3456 0.9433
Plasmodium falciparum mitogen-activated protein kinase 2 0.0167 0.05 0.1418
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.0827 0.2225
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0001 0.0001
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0272 0.0704
Leishmania major cathepsin L-like protease 0.1061 0.3456 0.9433
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0077 0.0204 0.0204
Onchocerca volvulus 0.0043 0.0092 0.0233
Mycobacterium leprae Probable lipase LipE 0.0043 0.0092 0.3245
Echinococcus granulosus cathepsin l cysteine peptidase 0.1061 0.3456 0.3455
Giardia lamblia Cathepsin L precursor 0.0266 0.0827 0.2205
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0266 0.0827 0.2225
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0084 0.0225 0.2494
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0006 0.0005
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.0146 0.0372
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0068 0.0068
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0979 0.2644
Echinococcus multilocularis cathepsin L 0.0588 0.1893 0.1892
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0092 0.0211
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0049 0.0048
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.0173 0.0172
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0049 0.0048
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0098 0.0272 0.0271
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0131 0.013
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0049 0.0049
Entamoeba histolytica cysteine protease, putative 0.0588 0.1893 0.5445
Loa Loa (eye worm) hypothetical protein 0.0266 0.0827 0.0826
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0266 0.0827 0.0826
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0084 0.0225 0.2494
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0074 0.0162
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0049 0.0048
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0588 0.1893 0.5146
Entamoeba histolytica cysteine proteinase, putative 0.0588 0.1893 0.5445
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0032 0.0054 0.0219
Brugia malayi Pre-SET motif family protein 0.0417 0.1326 0.1326
Brugia malayi nuclear receptor NHR-88 0.0031 0.0049 0.0048
Plasmodium vivax SET domain protein, putative 0.006 0.0146 0.039
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0042 0.0087
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0011 0.001
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0025 0.0025
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0032 0.0054 0.0483
Onchocerca volvulus Serine\/threonine kinase homolog 0.0098 0.0272 0.0755
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0032 0.0054 0.0483
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0024 0.0026
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.007 0.0069
Plasmodium falciparum cysteine proteinase falcipain 2a 0.1061 0.3456 1
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.007 0.007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1061 0.3456 0.9433
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0049 0.0048
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0103 0.0289 0.0752
Brugia malayi Cytochrome P450 family protein 0.0043 0.0089 0.0088
Entamoeba histolytica cysteine protease, putative 0.0588 0.1893 0.5445
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0098 0.0272 0.0271
Schistosoma mansoni protein kinase 0.0032 0.0053 0.0053
Onchocerca volvulus 0.1061 0.3456 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0049 0.0048
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0032 0.0054 0.0219
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0074 0.0073
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0115 0.0327 0.0327
Echinococcus granulosus geminin 0.0205 0.0625 0.0624
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0024 0.5
Brugia malayi Cytochrome P450 family protein 0.0088 0.024 0.0239
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0139 0.0409 0.0408
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0092 0.0927
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.007 0.0069
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1061 0.3456 0.9433
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0032 0.0054 0.0483
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0074 0.0073
Trypanosoma brucei glucose transporter, putative 0.0032 0.0054 0.0146
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0024 0.0023
Brugia malayi Cathepsin L-like precursor 0.1061 0.3456 0.3455
Plasmodium falciparum serine repeat antigen 8 0.0266 0.0827 0.2367
Giardia lamblia Hypothetical protein 0.0266 0.0827 0.2205
Brugia malayi cathepsin L-like precursor 0.0738 0.239 0.2389
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.0173 0.0172
Onchocerca volvulus 0.1061 0.3456 1
Toxoplasma gondii cathepsin B 0.1124 0.3664 1
Entamoeba histolytica cysteine protease, putative 0.0266 0.0827 0.2339
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0049 0.0048
Echinococcus multilocularis voltage dependent calcium channel 0.0186 0.0564 0.0563
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.005 0.0049
Echinococcus multilocularis cathepsin L cysteine protease 0.1061 0.3456 0.3455
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0225 0.0693 0.0692
Schistosoma mansoni hypothetical protein 0.0028 0.0042 0.0042
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0266 0.0827 0.2225
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0063 0.0155 0.0154
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0053 0.0053
Plasmodium vivax vivapain-3 0.0588 0.1893 0.5461
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0266 0.0827 0.2205
Loa Loa (eye worm) hypothetical protein 0.0063 0.0155 0.0154
Entamoeba histolytica protein kinase, putative 0.0032 0.0053 0.0085
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0588 0.1893 0.1893
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.0053 0.0122
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0024 0.0024
Onchocerca volvulus 0.0043 0.0092 0.0233
Entamoeba histolytica cysteine protease, putative 0.0588 0.1893 0.5445
Brugia malayi cathepsin L precursor 0.0266 0.0827 0.0826
Plasmodium falciparum protein kinase 6 0.0438 0.1396 0.402
Entamoeba histolytica cysteine protease, putative 0.0588 0.1893 0.5445
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0979 0.2644
Giardia lamblia Cathepsin L-like protease 0.0266 0.0827 0.2205
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.001
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0092 0.0498
Brugia malayi cathepsin F-like cysteine proteinase 0.0322 0.1014 0.1013
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0049 0.0049
Schistosoma mansoni kinase 0.0051 0.0116 0.0116
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0093 0.0256 1
Brugia malayi Sugar transporter family protein 0.0103 0.0289 0.0288
Toxoplasma gondii cathepsin CPC2 0.0266 0.0827 0.2236
Schistosoma mansoni cathepsin B (C01 family) 0.0266 0.0827 0.0827
Toxoplasma gondii preprocathepsin c precursor, putative 0.0266 0.0827 0.2236
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.005 0.005
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0032 0.0054 0.0483
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0103 0.0289 0.0288
Giardia lamblia Cathepsin L precursor 0.0266 0.0827 0.2205
Brugia malayi MH2 domain containing protein 0.0066 0.0166 0.0165
Toxoplasma gondii protein kinase, putative 0.0292 0.0912 0.247
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0049 0.0048
Trypanosoma brucei glucose transporter, putative 0.0032 0.0054 0.0146
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0032 0.0054 0.0219
Echinococcus granulosus General substrate transporter 0.0089 0.0241 0.024
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0049 0.0048
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0074 0.0201
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0049 0.0048
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.0053 0.0119
Echinococcus multilocularis zinc finger protein 0.002 0.0015 0.0014
Leishmania major protein kinase, putative 0.0032 0.0053 0.0146
Leishmania major cytochrome p450-like protein 0.0032 0.0054 0.0147
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0011 0.001
Echinococcus multilocularis cathepsin L cysteine protease 0.1061 0.3456 0.3455
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0024 0.047
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0138 0.0138
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0049 0.0049
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0032 0.0054 0.0219
Loa Loa (eye worm) hypothetical protein 0.0266 0.0827 0.0826
Loa Loa (eye worm) hypothetical protein 0.1061 0.3456 0.3455
Plasmodium falciparum serine repeat antigen 5 0.0266 0.0827 0.2367
Brugia malayi serine/threonine-protein kinase plk-2 0.0098 0.0272 0.0271
Entamoeba histolytica cysteine protease, putative 0.0266 0.0827 0.2339
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0068 0.0067
Mycobacterium tuberculosis Probable reductase 0.0084 0.0225 0.2494
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0186 0.0564 0.0563
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0001 0.0001
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0092 0.0091
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0074 0.0162
Echinococcus multilocularis voltage dependent calcium channel 0.0186 0.0564 0.0563
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0009
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0625 0.1672
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0077 0.0204 0.0204
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0006 0.0005
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0588 0.1893 0.1893
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0049 0.0048
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0032 0.0054 0.0054
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.019 0.1225
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1061 0.3456 0.9433
Loa Loa (eye worm) hypothetical protein 0.0031 0.005 0.0049
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0032 0.0054 0.0219
Loa Loa (eye worm) CYP4Cod1 0.0043 0.0089 0.0088
Leishmania major cytochrome p450-like protein 0.0043 0.0089 0.0242
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0067 0.0183
Trypanosoma brucei glucose transporter, putative 0.0032 0.0054 0.0146
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.0053 0.0122
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0131 0.0131
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0092 0.0091
Plasmodium vivax unspecified product 0.0266 0.0827 0.2367
Plasmodium falciparum thioredoxin reductase 0.0037 0.007 0.0169
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.005 0.0076
Schistosoma mansoni hypothetical protein 0.0205 0.0625 0.0625
Leishmania major glucose transporter, lmgt3 0.0032 0.0054 0.0146
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0011 0.001
Loa Loa (eye worm) calcium channel 0.0186 0.0564 0.0563
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.0053 0.0122
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0024 0.0037
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0092 0.0091
Echinococcus granulosus peregrin 0.0031 0.005 0.0049
Schistosoma mansoni hypothetical protein 0.0032 0.0054 0.0054
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0054 0.0107
Brugia malayi glutaminase DH11.1 0.0434 0.1382 0.1382
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0266 0.0827 0.2367
Giardia lamblia Cathepsin B precursor 0.1124 0.3664 1
Onchocerca volvulus 0.0043 0.0092 0.0233
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.0827 0.2225
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.0067 0.0157
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0032 0.0054 0.0219
Loa Loa (eye worm) hypothetical protein 0.0322 0.1014 0.1013
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.0053 0.0052
Brugia malayi glutathione reductase 0.0037 0.007 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0049 0.0048
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0979 0.2644
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0068 0.0068
Echinococcus granulosus cathepsin L 0.0588 0.1893 0.1892
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0078 0.0077
Brugia malayi Papain family cysteine protease containing protein 0.1061 0.3456 0.3455
Schistosoma mansoni glucose transport protein 0.0103 0.0289 0.0289
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0074 0.0175
Loa Loa (eye worm) MH2 domain-containing protein 0.0066 0.0166 0.0165
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0054 0.0146
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0049 0.0049
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0186 0.0564 0.0563
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0173 0.0173
Brugia malayi cathepsin Z-like cysteine proteinase 0.0266 0.0827 0.0826
Loa Loa (eye worm) hypothetical protein 0.0044 0.0093 0.0092
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0049 0.0048
Brugia malayi Bromodomain containing protein 0.0077 0.0203 0.0203
Echinococcus multilocularis RUN 0.0019 0.0011 0.001
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0131 0.013
Echinococcus granulosus RUN 0.0019 0.0011 0.001
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0032 0.0054 0.0219
Echinococcus multilocularis sodium channel protein 0.0048 0.0107 0.0106
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0131 0.0131
Schistosoma mansoni lipoxygenase 0.0115 0.0327 0.0327
Brugia malayi Thioredoxin reductase 0.0037 0.007 0.0069
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.0827 0.2225
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0067 0.0183
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.007 0.0069
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0272 0.0704
Schistosoma mansoni voltage-gated cation channel 0.0186 0.0564 0.0564
Schistosoma mansoni inositol monophosphatase 0.0038 0.0074 0.0074
Brugia malayi cathepsin L-like cysteine proteinase 0.0266 0.0827 0.0826
Giardia lamblia Hypothetical protein 0.0266 0.0827 0.2205
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0625 0.1672
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.005 0.0049
Loa Loa (eye worm) glutathione reductase 0.0037 0.007 0.0069
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0006 0.0006
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0092 0.0092
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.0173 0.0172
Plasmodium falciparum serine repeat antigen 3 0.0266 0.0827 0.2367
Brugia malayi Cathepsin L-like precursor 0.1061 0.3456 0.3455
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0054 0.0054
Schistosoma mansoni cytochrome P450 0.0032 0.0054 0.0054
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0115 0.0114
Echinococcus granulosus cysteine protease 0.0588 0.1893 0.1892
Onchocerca volvulus 0.0031 0.0049 0.0109
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0186 0.0564 0.0563
Plasmodium falciparum glutathione reductase 0.0037 0.007 0.0169
Trypanosoma brucei glucose transporter, putative 0.0032 0.0054 0.0146
Leishmania major trypanothione reductase 0.0037 0.007 0.019
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0131 0.013
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0049 0.0049
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0322 0.1014 0.1013
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0049 0.0048
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0092 0.0092
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0048 0.0107 0.0106
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.1061 0.3456 0.3455
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0092 0.0211
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0266 0.0827 0.2367
Toxoplasma gondii cathepsin CPL 0.1061 0.3456 0.9431
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0625 0.1672
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0032 0.0054 0.0219
Echinococcus granulosus cathepsin l1 0.0738 0.239 0.2389
Entamoeba histolytica cysteine protease, putative 0.0588 0.1893 0.5445
Loa Loa (eye worm) hypothetical protein 0.0031 0.0049 0.0048
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0049 0.0048
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0053 0.0052
Schistosoma mansoni lipoxygenase 0.008 0.0213 0.0213
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0042 0.0041
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0042 0.0041
Loa Loa (eye worm) hypothetical protein 0.3039 1 1
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0042 0.0088
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.019 0.1225
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0049 0.0048
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0049 0.0048
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0032 0.0054 0.0483
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0272 0.0704
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1061 0.3456 0.3455
Brugia malayi Inositol-1 0.0038 0.0074 0.0073
Echinococcus multilocularis cathepsin L 0.0266 0.0827 0.0826
Brugia malayi Cathepsin L-like precursor 0.1061 0.3456 0.3455
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1061 0.3456 0.9433
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1061 0.3456 0.9433
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0032 0.0054 0.0219
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0068 0.0173 0.0433
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0186 0.0564 0.0563
Trypanosoma brucei glucose transporter, putative 0.0032 0.0054 0.0146
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0049 0.0048
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.0031 0.005 0.0049
Brugia malayi cytochrome P450 0.0032 0.0054 0.0053
Mycobacterium tuberculosis Conserved protein 0.0043 0.0092 0.0927
Trypanosoma cruzi cruzipain precursor, putative 0.0322 0.1014 0.1014
Entamoeba histolytica cysteine proteinase, putative 0.0588 0.1893 0.5445
Brugia malayi Papain family cysteine protease containing protein 0.0266 0.0827 0.0826
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0054 0.0146
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0266 0.0827 0.2367
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0266 0.0827 0.2367
Loa Loa (eye worm) hypothetical protein 0.0043 0.0092 0.0091
Entamoeba histolytica cysteine proteinase, putative 0.1061 0.3456 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0049 0.0049
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0049 0.0048
Schistosoma mansoni loxhd1 0.0019 0.0011 0.0011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0131 0.0131
Loa Loa (eye worm) hypothetical protein 0.0031 0.0049 0.0048
Entamoeba histolytica cysteine protease, putative 0.0266 0.0827 0.2339
Echinococcus granulosus voltage dependent calcium channel 0.0186 0.0564 0.0563
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0074 0.0162
Giardia lamblia Cathepsin B precursor 0.0266 0.0827 0.2205
Loa Loa (eye worm) hypothetical protein 0.0266 0.0827 0.0826
Brugia malayi Cathepsin L-like cysteine proteinase 0.0738 0.239 0.2389
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0032 0.0054 0.0219
Loa Loa (eye worm) hypothetical protein 0.0051 0.0115 0.0114
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.0053 0.0052
Loa Loa (eye worm) hypothetical protein 0.0049 0.0109 0.0108
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0092 0.0927
Entamoeba histolytica cysteine protease, putative 0.0588 0.1893 0.5445
Loa Loa (eye worm) hypothetical protein 0.0025 0.0031 0.003
Mycobacterium ulcerans glutaminase 0.0434 0.1382 1
Plasmodium vivax vivapain-2 0.1061 0.3456 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.0289 0.0288
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0024 0.0023
Giardia lamblia Cathepsin B precursor 0.0266 0.0827 0.2205
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0266 0.0827 0.2367
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.019 0.0494
Loa Loa (eye worm) hypothetical protein 0.0043 0.0092 0.0091
Plasmodium falciparum serine repeat antigen 4 0.0266 0.0827 0.2367
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.0289 0.0288
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0011 0.001
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0266 0.0827 0.0826
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1061 0.3456 0.943
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0049 0.0049
Entamoeba histolytica cysteine protease, putative 0.0266 0.0827 0.2339
Loa Loa (eye worm) glutaminase 2 0.0434 0.1382 0.1382
Brugia malayi hypothetical protein 0.0063 0.0155 0.0154
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0266 0.0827 0.2225
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0092 0.0927
Leishmania major cathepsin L-like protease 0.1061 0.3456 0.9433
Entamoeba histolytica cysteine proteinase, putative 0.0588 0.1893 0.5445
Loa Loa (eye worm) hypothetical protein 0.0026 0.0035 0.0034
Schistosoma mansoni inositol monophosphatase 0.0038 0.0074 0.0074
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0625 0.1672
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.019 0.052
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0053 0.0052
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0049 0.0109
Loa Loa (eye worm) hypothetical protein 0.004 0.0079 0.0078
Echinococcus multilocularis General substrate transporter 0.0089 0.0241 0.024
Entamoeba histolytica cysteine proteinase 1, putative 0.0588 0.1893 0.5445
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0032 0.0054 0.0219
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1061 0.3456 0.943
Entamoeba histolytica serine/threonine protein kinase, putative 0.0098 0.0272 0.0721
Onchocerca volvulus 0.1061 0.3456 1
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0266 0.0827 0.2367
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0032 0.0054 0.0147
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0061 0.0061
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0139 0.0409 0.0408
Loa Loa (eye worm) hypothetical protein 0.0266 0.0827 0.0826
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.3039 1 1
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.0067 0.0162
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0061 0.1968
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0049 0.0048
Plasmodium vivax vivapain-2 0.1061 0.3456 1
Giardia lamblia Cathepsin L precursor 0.0266 0.0827 0.2205
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.0289 0.0288
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0266 0.0827 0.0827
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0092 0.0211
Schistosoma mansoni glucose transport protein 0.0103 0.0289 0.0289
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0054 0.0107
Loa Loa (eye worm) transcription factor SMAD2 0.0066 0.0166 0.0165
Trypanosoma cruzi cruzipain precursor, putative 0.1061 0.3456 0.3456
Brugia malayi hypothetical protein 0.0019 0.0011 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0054 0.0107
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.0053 0.0119
Giardia lamblia Cathepsin L precursor 0.0266 0.0827 0.2205
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0272 0.0704
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0625 0.1672
Plasmodium falciparum serine repeat antigen 9 0.0266 0.0827 0.2367
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0067 0.0183
Plasmodium falciparum cysteine proteinase falcipain 1 0.0588 0.1893 0.5461
Echinococcus multilocularis cathepsin b 0.3039 1 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0043 0.0089 0.0088
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.005 0.0049
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.0255 0.0254
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0032 0.0054 0.0219
Trypanosoma brucei glucose transporter, putative 0.0032 0.0054 0.0146
Toxoplasma gondii thioredoxin reductase 0.0037 0.007 0.0164
Trichomonas vaginalis set domain proteins, putative 0.0474 0.1517 0.4117
Trypanosoma cruzi cysteine peptidase, putative 0.0322 0.1014 0.1014
Schistosoma mansoni hypothetical protein 0.0205 0.0625 0.0625
Loa Loa (eye worm) glutaminase 0.0434 0.1382 0.1382
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.0053 0.0119
Entamoeba histolytica cysteine protease, putative 0.0266 0.0827 0.2339
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0266 0.0827 0.0827
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.0053 0.0122
Loa Loa (eye worm) hypothetical protein 0.0186 0.0564 0.0563
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.005 0.1544
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0032 0.0054 0.0483
Entamoeba histolytica cysteine protease, putative 0.0588 0.1893 0.5445
Schistosoma mansoni hypothetical protein 0.0103 0.0289 0.0289
Loa Loa (eye worm) ctsf protein 0.1061 0.3456 0.3455
Plasmodium falciparum serine repeat antigen 2 0.0266 0.0827 0.2367
Loa Loa (eye worm) hypothetical protein 0.0028 0.0042 0.0041
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0738 0.239 0.6509
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0625 0.1672
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0053 0.0052
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0011 0.001
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0061 0.0562
Giardia lamblia Encystation-specific protease 0.0266 0.0827 0.2205
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.3039 1 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0049 0.0048
Plasmodium vivax vivapain-1 0.0588 0.1893 0.5461
Plasmodium falciparum phd finger protein, putative 0.0028 0.0042 0.0088
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0068 0.0067
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.0173 0.0172
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1061 0.3456 0.943
Loa Loa (eye worm) hypothetical protein 0.0043 0.0092 0.0091
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.1124 0.3664 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1061 0.3456 0.9433
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0131 0.013
Schistosoma mansoni protein kinase 0.0032 0.0053 0.0053
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0588 0.1893 0.1893
Brugia malayi Cathepsin L-like precursor 0.0738 0.239 0.2389
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0084 0.0225 0.2494
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0032 0.0054 0.0483
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0266 0.0827 0.2339
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.0289 0.0288
Schistosoma mansoni protein kinase 0.0032 0.0053 0.0053
Giardia lamblia Cysteine protease 0.0266 0.0827 0.2205
Trichomonas vaginalis conserved hypothetical protein 0.0266 0.0827 0.2225
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0074 0.0074
Giardia lamblia Cathepsin B precursor 0.0266 0.0827 0.2205
Echinococcus granulosus cathepsin L 0.0266 0.0827 0.0826
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0032 0.0054 0.0483
Entamoeba histolytica cysteine proteinase 2 0.0588 0.1893 0.5445
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1061 0.3456 0.943
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0032 0.0054 0.0219
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1061 0.3456 0.943
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0032 0.0054 0.0483
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1061 0.3456 0.943
Loa Loa (eye worm) fibroinase 0.1061 0.3456 0.3455
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.0053 0.0052
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1061 0.3456 0.943
Schistosoma mansoni cathepsin F (C01 family) 0.1061 0.3456 0.3456
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0053 0.0106
Loa Loa (eye worm) hypothetical protein 0.0031 0.0049 0.0048
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1061 0.3456 0.943
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0266 0.0827 0.0827
Brugia malayi Cathepsin L-like precursor 0.0322 0.1014 0.1013
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0024 0.0065
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0266 0.0827 0.2367
Onchocerca volvulus Cathepsin L homolog 0.1061 0.3456 1
Toxoplasma gondii ABC1 family protein 0.0043 0.0092 0.0224
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0186 0.0564 0.0563
Brugia malayi Papain family cysteine protease containing protein 0.0266 0.0827 0.0826
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0092 0.0927
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0049 0.0049
Mycobacterium tuberculosis Conserved protein 0.0043 0.0092 0.0927
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.0827 0.2225
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0167 0.05 0.1418
Plasmodium vivax serine-repeat antigen (SERA) 0.0266 0.0827 0.2367
Loa Loa (eye worm) inositol-1 0.0038 0.0074 0.0073
Loa Loa (eye worm) hypothetical protein 0.0738 0.239 0.2389
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0049 0.0048
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0049 0.0048
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0272 0.0704
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0142 0.0141
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0266 0.0827 0.2367
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0049 0.0048
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0049 0.0048
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0186 0.0564 0.0563
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0115 0.0114
Brugia malayi PHD-finger family protein 0.0028 0.0042 0.0041
Echinococcus multilocularis cysteine protease 0.1061 0.3456 0.3455
Schistosoma mansoni cathepsin F (C01 family) 0.0738 0.239 0.239
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0092 0.0092
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0032 0.0054 0.0219
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.0053 0.0052
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0049 0.0048
Plasmodium falciparum proline--tRNA ligase 0.0036 0.0067 0.0162
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0032 0.0054 0.0219
Leishmania major glucose transporter, lmgt1 0.0032 0.0054 0.0146
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1124 0.3664 0.3664
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.007 0.0668
Plasmodium vivax unspecified product 0.0588 0.1893 0.5461
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0266 0.0827 0.0827
Trypanosoma brucei glucose transporter 2A 0.0032 0.0054 0.0146
Trypanosoma cruzi cysteine proteinase, putative 0.0588 0.1893 0.1893
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0024 0.0039
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0186 0.0564 0.0564
Entamoeba histolytica cysteine protease, putative 0.0588 0.1893 0.5445
Giardia lamblia Cysteine protease 0.0266 0.0827 0.2205
Schistosoma mansoni rab6-interacting 0.0019 0.0011 0.0011
Trypanosoma cruzi polo-like protein kinase, putative 0.0098 0.0272 0.0272
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0115 0.0114
Leishmania major cytochrome p450-like protein 0.0032 0.0054 0.0147
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0032 0.0054 0.0483
Brugia malayi hypothetical protein 0.0019 0.0011 0.001
Plasmodium vivax CDK-related protein kinase 6, putative 0.0438 0.1396 0.402
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0011 0.001
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0032 0.0054 0.0483
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0077 0.0204 0.0203
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0032 0.0054 0.0483
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0266 0.0827 0.0827
Loa Loa (eye worm) hypothetical protein 0.0042 0.0087 0.0086
Echinococcus multilocularis geminin 0.0205 0.0625 0.0624
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.3039 1 1
Plasmodium falciparum serine repeat antigen 6 0.0266 0.0827 0.2367
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.007 0.0169
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0092 0.0498
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.3039 1 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0067 0.0067
Schistosoma mansoni hypothetical protein 0.0016 0.0001 0.0001
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0266 0.0827 0.2367

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0522 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 5.6234 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3601 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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