Detailed information for compound 1392442

Basic information

Technical information
  • TDR Targets ID: 1392442
  • Name: NCGC00074615-01
  • MW: 627.707 | Formula: C33H45F4NO6
  • H donors: 0 H acceptors: 1 LogP: 4.63 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: COCC1C2CC[C@@H]3[C@@H]4C2=C([C@@H](C1COC)C)CN([C@]4(C)COC3OCc1ccc(cc1C(F)(F)F)F)C(=O)OC(C)(C)C
  • InChi: 1S/C33H45F4NO6/c1-18-23-13-38(30(39)44-31(2,3)4)32(5)17-43-29(42-14-19-8-9-20(34)12-26(19)33(35,36)37)22-11-10-21(27(23)28(22)32)25(16-41-7)24(18)15-40-6/h8-9,12,18,21-22,24-25,28-29H,10-11,13-17H2,1-7H3/t18-,21?,22+,24?,25?,28+,29?,32+/m0/s1
  • InChiKey: DUKJYOYRVFEOOI-MZKYGMSNSA-N  


Substructure search Similarity search

Network

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Synonyms

  • CMLD1_000318
  • SDCCGMLS-0091635.P001
  • UPCMLD00CCLH1-045

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 9 Starlite/ChEMBL No references
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 cytochrome P450, family 2, subfamily C, polypeptide 9 490 aa 441 aa 21.8 %
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0078 0.1291 0.1387
Brugia malayi calpain family protein 1 0.0487 0.9438 1
Entamoeba histolytica calpain large subunit domain III containing protein 0.0129 0.2302 0.5577
Brugia malayi cathepsin Z-like cysteine proteinase 0.0027 0.0277 0.0293
Entamoeba histolytica cysteine protease, putative 0.0053 0.0795 0.1737
Echinococcus granulosus calpain 5 0.0184 0.3402 0.3402
Toxoplasma gondii cathepsin CPL 0.0091 0.1555 0.385
Loa Loa (eye worm) hypothetical protein 0.0027 0.0277 0.0293
Trypanosoma brucei Component of motile flagella 41 0.0028 0.0299 0.0274
Mycobacterium ulcerans proteasome PrcA 0.003 0.035 0.0407
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0113 0.0113
Echinococcus multilocularis neurocalcin 0.0028 0.0299 0.0299
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0844 0.1693
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0027 0.0277 0.0416
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.2458 0.5891
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0055 0.0844 0.1693
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0078 0.1291 0.2856
Schistosoma mansoni centrin-related 0.0028 0.0299 0.0188
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0091 0.1555 0.3342
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0055 0.0844 0.0823
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0091 0.1555 0.1647
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.1555 0.3342
Leishmania major calpain family cysteine protease-like protein 0.0055 0.0844 0.1693
Trypanosoma brucei mitochondrial calcium uptake 1 0.0028 0.0299 0.0274
Loa Loa (eye worm) proteasome subunit beta type 2 0.0074 0.121 0.1282
Echinococcus multilocularis cysteine protease 0.0091 0.1555 0.1555
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.003 0.035 0.024
Loa Loa (eye worm) calpain D 0.0055 0.0844 0.0895
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0844 0.0823
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.003 0.035 0.024
Echinococcus multilocularis calmodulin 0.0028 0.0299 0.0299
Trichomonas vaginalis calmodulin-2, putative 0.0028 0.0299 0.043
Trichomonas vaginalis calcium binding protein, putative 0.0028 0.0299 0.043
Loa Loa (eye worm) hypothetical protein 0.0038 0.0503 0.0533
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.003 0.035 0.0198
Loa Loa (eye worm) calpain family protein 1 0.0487 0.9438 1
Echinococcus granulosus calcium uptake protein 1 0.0028 0.0307 0.0307
Loa Loa (eye worm) hypothetical protein 0.0019 0.0113 0.012
Echinococcus multilocularis proteasome (prosome, macropain) 0.0216 0.4038 0.4038
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0028 0.0307 0.0143
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.003 0.035 0.0603
Brugia malayi Cytochrome P450 family protein 0.0053 0.0807 0.0855
Entamoeba histolytica cysteine protease, putative 0.0053 0.0795 0.1737
Trypanosoma cruzi programmed cell death 6 protein-like, putative 0.0028 0.0299 0.0133
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0074 0.121 0.1111
Toxoplasma gondii cathepsin CPC2 0.0027 0.0277 0.0685
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0313 0.0313
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0335 0.083
Plasmodium vivax vivapain-1 0.0053 0.0795 0.1408
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0074 0.121 0.2543
Brugia malayi Cathepsin L-like precursor 0.0065 0.1037 0.1098
Trypanosoma brucei calpain-like protein, putative 0.0184 0.3402 0.8344
Entamoeba histolytica cysteine protease, putative 0.0053 0.0795 0.1737
Leishmania major hypothetical protein, unknown function 0.0055 0.0844 0.1693
Loa Loa (eye worm) hypothetical protein 0.0487 0.9438 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0844 0.1693
Trypanosoma brucei centrin, putative 0.0028 0.0299 0.0274
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0335 0.0335
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0184 0.3402 0.4054
Entamoeba histolytica cysteine proteinase, putative 0.0053 0.0795 0.1737
Trypanosoma brucei proteasome beta 3 subunit, putative 0.003 0.035 0.0407
Trypanosoma brucei caltractin, putative 0.0028 0.0299 0.0274
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.003 0.035 0.0549
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0844 0.1693
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.003 0.035 0.024
Echinococcus multilocularis calpain family protein 1, d 0.0359 0.6881 0.6881
Trichomonas vaginalis calcineurin B subunit, putative 0.0028 0.0299 0.043
Brugia malayi Cathepsin L-like precursor 0.0091 0.1555 0.1647
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.003 0.035 0.0549
Brugia malayi Proteasome A-type and B-type family protein 0.003 0.035 0.0371
Leishmania major i/6 autoantigen-like protein 0.0028 0.0299 0.0274
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0421 0.8107 0.8092
Plasmodium falciparum proteasome subunit beta type-6, putative 0.003 0.035 0.0195
Trypanosoma cruzi conserved protein 0.0055 0.0844 0.0823
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.003 0.035 0.0407
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0027 0.0277 0.0165
Plasmodium vivax vivapain-2 0.0091 0.1555 0.3421
Giardia lamblia Hypothetical protein 0.0028 0.0307 0.008
Entamoeba histolytica cysteine protease, putative 0.0091 0.1555 0.3673
Brugia malayi cathepsin L-like precursor 0.0065 0.1037 0.1098
Echinococcus granulosus cathepsin L cysteine protease 0.0053 0.0795 0.0795
Toxoplasma gondii hypothetical protein 0.0055 0.0844 0.2091
Toxoplasma gondii heat shock protein hslv, putative 0.003 0.035 0.0866
Leishmania major proteasome beta 2 subunit, putative 0.003 0.035 0.0407
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0091 0.1555 0.3398
Loa Loa (eye worm) hypothetical protein 0.0146 0.2646 0.2804
Trypanosoma cruzi Aph-1 protein, putative 0.0056 0.0854 0.0835
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0113 0.0113
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0027 0.0277 0.0293
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0026 0.0263 0.0279
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0078 0.1291 0.1193
Entamoeba histolytica cysteine protease, putative 0.0053 0.0795 0.1737
Brugia malayi gamma-secretase subunit aph-1 0.0143 0.2591 0.2746
Entamoeba histolytica cysteine proteinase, putative 0.0091 0.1555 0.3673
Echinococcus multilocularis Proteasome subunit alpha type 7 0.003 0.035 0.035
Onchocerca volvulus 0.0091 0.1555 0.2322
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.003 0.035 0.0198
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0844 0.1693
Brugia malayi proteasome subunit beta type 2 0.0074 0.121 0.1282
Trypanosoma cruzi centrin, putative 0.0028 0.0299 0.0133
Toxoplasma gondii proteasome subunit alpha1, putative 0.003 0.035 0.0866
Echinococcus granulosus EF HAND 1 calcium binding site 0.0028 0.0299 0.0299
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.2458 0.5891
Schistosoma mansoni cathepsin S (C01 family) 0.0027 0.0277 0.0165
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.003 0.035 0.0603
Loa Loa (eye worm) hypothetical protein 0.0019 0.0113 0.012
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0027 0.0277 0.0035
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.003 0.035 0.024
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0844 0.1693
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0078 0.1291 0.2731
Brugia malayi Proteasome A-type and B-type family protein 0.003 0.035 0.0371
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0945 0.0842
Trypanosoma cruzi I/6 autoantigen, putative 0.0028 0.0299 0.0133
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0285 0.5418 0.574
Plasmodium vivax proteasome subunit alpha type-5, putative 0.003 0.035 0.0229
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0335 0.0225
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0844 0.0823
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0515 0.9992 0.9992
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0844 0.1693
Trypanosoma brucei proteasome alpha 7 subunit 0.003 0.035 0.0407
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0113 0.012
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0078 0.1291 0.3198
Echinococcus multilocularis calpain A 0.0516 1 1
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.003 0.035 0.0371
Schistosoma mansoni calmodulin related calcium binding protein 0.0028 0.0299 0.0188
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.1555 0.3342
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0113 0.0113
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0113 0.0113
Schistosoma mansoni mitochondrial solute carrier 0.0028 0.0299 0.0188
Onchocerca volvulus 0.003 0.0335 0.0106
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0074 0.121 0.2997
Echinococcus multilocularis calmodulin 0.0028 0.0299 0.0299
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0113 0.012
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0074 0.121 0.2795
Onchocerca volvulus Cathepsin F homolog 0.0091 0.1555 0.2322
Loa Loa (eye worm) hypothetical protein 0.0028 0.0299 0.0316
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0053 0.0795 0.076
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.003 0.035 0.0198
Leishmania major kinesin, putative 0.0129 0.2302 0.5485
Toxoplasma gondii troponin c, isotype gamma, putative 0.0028 0.0299 0.0739
Brugia malayi Cathepsin L-like precursor 0.0065 0.1037 0.1098
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0844 0.1693
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0193 0.0205
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0421 0.8107 1
Echinococcus granulosus neurocalcin 0.0028 0.0299 0.0299
Trichomonas vaginalis calmodulin, putative 0.0028 0.0299 0.043
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0091 0.1555 0.1555
Leishmania major proteasome alpha 7 subunit, putative 0.003 0.035 0.0407
Echinococcus multilocularis centrin 2 0.0028 0.0299 0.0299
Plasmodium vivax proteasome subunit alpha type-4, putative 0.003 0.035 0.0229
Trypanosoma cruzi cysteine peptidase, putative 0.0136 0.2458 0.2862
Loa Loa (eye worm) proteasome subunit alpha type 1 0.003 0.035 0.0371
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0027 0.0277 0.0379
Echinococcus granulosus centrin 2 0.0028 0.0299 0.0299
Echinococcus multilocularis Proteasome subunit alpha type 7 0.003 0.035 0.035
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0844 0.1693
Echinococcus multilocularis expressed protein 0.036 0.6912 0.6912
Entamoeba histolytica cysteine protease, putative 0.0027 0.0277 0.0416
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0078 0.1291 0.2698
Toxoplasma gondii preprocathepsin c precursor, putative 0.0027 0.0277 0.0685
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0027 0.0277 0.0379
Brugia malayi cathepsin Z-like cysteine proteinase 0.0027 0.0277 0.0293
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.2458 0.5891
Entamoeba histolytica cysteine protease, putative 0.0053 0.0795 0.1737
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0027 0.0277 0.0416
Loa Loa (eye worm) proteasome subunit beta type 3 0.003 0.035 0.0371
Loa Loa (eye worm) proteasome subunit alpha type 6 0.003 0.035 0.0371
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0844 0.0823
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0184 0.3402 0.8344
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.003 0.035 0.0198
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0844 0.0823
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0089 0.152 0.1611
Plasmodium falciparum calpain 0.0055 0.0844 0.1509
Brugia malayi proteasome subunit beta type 3 0.003 0.035 0.0371
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0945 0.1956
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0299 0.043
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.003 0.035 0.0195
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0945 0.1956
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0277 0.0379
Trypanosoma cruzi caltractin, putative 0.0028 0.0299 0.0133
Brugia malayi Cathepsin L-like precursor 0.0026 0.0263 0.0279
Loa Loa (eye worm) cysteine protease 0.0091 0.1555 0.1647
Trichomonas vaginalis set domain proteins, putative 0.0235 0.4427 1
Entamoeba histolytica cysteine proteinase, putative 0.0065 0.1037 0.2353
Toxoplasma gondii calcium-dependent protein kinase 0.0028 0.0307 0.076
Entamoeba histolytica calcium-binding protein, putative 0.0028 0.0299 0.0473
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0184 0.3402 0.4054
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0149 0.2698 0.6515
Leishmania major proteasome beta 5 subunit, putative 0.0216 0.4038 1
Leishmania major calmodulin, putative 0.0028 0.0299 0.0274
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0184 0.3402 0.8344
Giardia lamblia Cathepsin B precursor 0.0149 0.2698 0.6438
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0184 0.3402 0.8344
Brugia malayi Cathepsin L-like precursor 0.0091 0.1555 0.1647
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.003 0.035 0.0198
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0945 0.1614
Loa Loa (eye worm) proteasome subunit beta type 1 0.0078 0.1291 0.1368
Schistosoma mansoni rab 0.0028 0.0299 0.0188
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0078 0.1291 0.1291
Schistosoma mansoni calcium binding atopy-related autoantigen 0.0028 0.0307 0.0196
Schistosoma mansoni hypothetical protein 0.0089 0.152 0.1424
Echinococcus granulosus Proteasome subunit alpha type 7 0.003 0.035 0.035
Echinococcus granulosus calbindin 32 0.0028 0.0307 0.0307
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.2458 0.5891
Entamoeba histolytica protein kinase, putative 0.0129 0.2302 0.5577
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0065 0.1037 0.2141
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0028 0.0299 0.0133
Trypanosoma cruzi cysteine proteinase, putative 0.0053 0.0795 0.076
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.003 0.035 0.0866
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.003 0.035 0.0549
Onchocerca volvulus 0.0146 0.2646 0.4304
Plasmodium vivax proteasome subunit alpha type-7, putative 0.003 0.035 0.0229
Entamoeba histolytica cysteine protease, putative 0.0027 0.0277 0.0416
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.003 0.035 0.0603
Echinococcus multilocularis tumor protein p63 0.0326 0.6232 0.6232
Echinococcus granulosus survival motor neuron protein 1 0.0438 0.8448 0.8448
Trypanosoma cruzi mitochondrial calcium uptake 1, putative 0.0028 0.0299 0.0133
Trypanosoma cruzi centrin-3 0.0028 0.0299 0.0133
Onchocerca volvulus 0.0028 0.0307 0.0055
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0027 0.0277 0.0293
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.003 0.035 0.0371
Loa Loa (eye worm) hypothetical protein 0.0304 0.5782 0.6126
Plasmodium vivax proteasome subunit beta type-7, putative 0.003 0.035 0.0229
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.003 0.035 0.0866
Plasmodium vivax proteasome subunit beta type-4, putative 0.003 0.035 0.0229
Loa Loa (eye worm) hypothetical protein 0.0019 0.0113 0.012
Trypanosoma brucei cysteine peptidase, putative 0.0055 0.0844 0.1693
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.003 0.035 0.024
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0091 0.1555 0.1555
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0027 0.0277 0.0035
Echinococcus multilocularis EF hand domain containing family member A2 0.0028 0.0299 0.0299
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0113 0.0113
Leishmania major proteasome alpha 1 subunit, putative 0.003 0.035 0.0407
Brugia malayi calpain D 0.0055 0.0844 0.0895
Echinococcus granulosus proteasome subunit alpha type 2 0.003 0.035 0.035
Trichomonas vaginalis hypothetical protein 0.0055 0.0844 0.1695
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.003 0.035 0.0407
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0113 0.0113
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.003 0.035 0.0198
Giardia lamblia 20S proteasome alpha subunit 6 0.003 0.035 0.0195
Trypanosoma cruzi major cysteine proteinase, putative 0.0072 0.118 0.1247
Schistosoma mansoni hypothetical protein 0.0055 0.0844 0.074
Loa Loa (eye worm) bone morphogenetic protein 1b 0.004 0.0536 0.0567
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0945 0.0945
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0216 0.4038 0.3973
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0027 0.0277 0.0379
Onchocerca volvulus 0.0028 0.0299 0.004
Schistosoma mansoni calmodulin 0.0028 0.0299 0.0188
Brugia malayi fibroinase precursor 0.0027 0.0277 0.0293
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.003 0.035 0.024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0277 0.0379
Loa Loa (eye worm) hypothetical protein 0.0019 0.0113 0.012
Echinococcus multilocularis gamma secretase subunit aph 1 0.0143 0.2591 0.2591
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0113 0.0113
Brugia malayi calcium-binding protein 0.0028 0.0299 0.0316
Trypanosoma brucei protein I/6 0.0028 0.0299 0.0274
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0113 0.012
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0795 0.1564
Giardia lamblia Proteasome subunit beta type 2 0.0074 0.121 0.2482
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.003 0.035 0.0603
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.003 0.035 0.0407
Schistosoma mansoni hypothetical protein 0.0028 0.0299 0.0188
Toxoplasma gondii calmodulin CAM1 0.0028 0.0307 0.076
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0091 0.1555 0.3342
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0027 0.0277 0.0035
Echinococcus granulosus cathepsin l1 0.0065 0.1037 0.1037
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0055 0.0844 0.1695
Schistosoma mansoni reticulocalbin 0.0028 0.0307 0.0196
Trichomonas vaginalis centrin, putative 0.0028 0.0299 0.043
Loa Loa (eye worm) hypothetical protein 0.0065 0.1037 0.1098
Leishmania major proteasome beta-1 subunit, putative 0.003 0.035 0.0407
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0065 0.1037 0.2141
Schistosoma mansoni cathepsin F (C01 family) 0.0091 0.1555 0.1459
Echinococcus granulosus proteasome subunit beta type 6 0.003 0.035 0.035
Entamoeba histolytica cysteine proteinase, putative 0.0053 0.0795 0.1737
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.003 0.035 0.0866
Trichomonas vaginalis calcium binding proteins, putative 0.0028 0.0299 0.043
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.1555 0.3342
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0113 0.0113
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.003 0.035 0.0198
Brugia malayi Papain family cysteine protease containing protein 0.0091 0.1555 0.1647
Brugia malayi Proteasome subunit alpha type 7-1 0.003 0.035 0.0371
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0193 0.0205
Brugia malayi Cathepsin L-like precursor 0.0091 0.1555 0.1647
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0091 0.1555 0.3342
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0844 0.1693
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.003 0.035 0.0549
Giardia lamblia Proteasome subunit beta type 1 0.0078 0.1291 0.2698
Trypanosoma cruzi cysteine peptidase, putative 0.0136 0.2458 0.2862
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0028 0.0299 0.0133
Loa Loa (eye worm) calpain 5 0.0129 0.2302 0.2439
Entamoeba histolytica calmodulin, putative 0.0028 0.0299 0.0473
Brugia malayi calpain 5 0.0055 0.0844 0.0895
Giardia lamblia 20S proteasome alpha subunit 2 0.003 0.035 0.0195
Entamoeba histolytica cysteine protease, putative 0.0027 0.0277 0.0416
Brugia malayi programmed cell death protein 6 0.0028 0.0299 0.0316
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.003 0.035 0.0603
Trypanosoma cruzi cysteine peptidase, putative 0.0091 0.1555 0.172
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0421 0.8107 0.8092
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0055 0.0844 0.0823
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0027 0.0277 0.0379
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0844 0.1693
Brugia malayi Papain family cysteine protease containing protein 0.0027 0.0277 0.0293
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0216 0.4038 1
Trypanosoma cruzi cysteine peptidase, putative 0.0026 0.0263 0.0088
Trichomonas vaginalis calmodulin, putative 0.0028 0.0299 0.043
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.003 0.035 0.024
Schistosoma mansoni ef hand domain family member A2 0.0028 0.0299 0.0188
Echinococcus granulosus gamma secretase subunit aph 1 0.0143 0.2591 0.2591
Schistosoma mansoni calpain C (C02 family) 0.0184 0.3402 0.3329
Echinococcus multilocularis survival motor neuron protein 1 0.0438 0.8448 0.8448
Giardia lamblia 20S proteasome alpha subunit 4 0.003 0.035 0.0195
Leishmania major cathepsin L-like protease 0.0136 0.2458 0.5891
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0945 0.2341
Leishmania major proteasome beta 2 subunit, putative 0.0074 0.121 0.2645
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.003 0.035 0.024
Echinococcus granulosus neuronal calcium sensor 0.0028 0.0299 0.0299
Loa Loa (eye worm) hypothetical protein 0.0027 0.0277 0.0293
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0184 0.3402 0.4054
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.003 0.035 0.0407
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.003 0.035 0.0195
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0053 0.0795 0.1564
Echinococcus granulosus subfamily T1A non peptidase ue 0.003 0.035 0.035
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0193 0.0205
Entamoeba histolytica cysteine protease, putative 0.0053 0.0795 0.1737
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0055 0.0844 0.0823
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.011 0.194 0.2207
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.003 0.035 0.0198
Entamoeba histolytica cysteine protease, putative 0.0053 0.0795 0.1737
Plasmodium vivax centrin-1, putative 0.0028 0.0299 0.0094
Plasmodium vivax unspecified product 0.0053 0.0795 0.1408
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.003 0.035 0.0195
Leishmania major centrin, putative,caltractin, putative 0.0028 0.0299 0.0274
Trichomonas vaginalis myosin light chain 1, putative 0.0028 0.0299 0.043
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0078 0.1291 0.3002
Loa Loa (eye worm) hypothetical protein 0.0091 0.1555 0.1647
Trypanosoma brucei Calpain-like protein 2 0.0055 0.0844 0.1693
Onchocerca volvulus 0.0091 0.1555 0.2322
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0027 0.0277 0.0165
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0055 0.0844 0.1695
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.003 0.035 0.0603
Onchocerca volvulus 0.0028 0.0299 0.004
Echinococcus multilocularis programmed cell death protein 0.0028 0.0299 0.0299
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0277 0.0379
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0113 0.0113
Giardia lamblia Cathepsin B precursor 0.0149 0.2698 0.6438
Plasmodium falciparum cysteine proteinase falcipain 1 0.0053 0.0795 0.1378
Echinococcus multilocularis programmed cell death protein 0.0028 0.0299 0.0299
Loa Loa (eye worm) hypothetical protein 0.0027 0.0277 0.0293
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0027 0.0277 0.0293
Brugia malayi Proteasome A-type and B-type family protein 0.0216 0.4038 0.4279
Trypanosoma brucei calpain-like protein, putative 0.0184 0.3402 0.8344
Echinococcus granulosus cathepsin b 0.0421 0.8107 0.8107
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.003 0.035 0.0198
Trypanosoma brucei Calpain-like protein CALP1.3 0.0055 0.0844 0.1693
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0027 0.0277 0.0165
Entamoeba histolytica calcium binding family protein 0.0028 0.0299 0.0473
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.003 0.035 0.0407
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0027 0.0277 0.0035
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0027 0.0277 0.0379
Echinococcus granulosus proteasome subunit beta type 7 0.003 0.035 0.035
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0027 0.0277 0.0293
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0515 0.9992 0.9992
Entamoeba histolytica cysteine protease, putative 0.0027 0.0277 0.0416
Leishmania major cathepsin L-like protease 0.0136 0.2458 0.5891
Echinococcus multilocularis calcium uptake protein 1 0.0028 0.0307 0.0307
Onchocerca volvulus 0.0091 0.1555 0.2322
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.1555 0.3342
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0027 0.0277 0.0035
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0027 0.0277 0.0165
Echinococcus multilocularis Proteasome, subunit alpha beta 0.003 0.035 0.035
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0055 0.0844 0.1695
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0945 0.1956
Schistosoma mansoni calpain-7 (C02 family) 0.0184 0.3402 0.3329
Echinococcus granulosus proteasome prosome macropain 0.0216 0.4038 0.4038
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.003 0.035 0.035
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.003 0.035 0.0195
Trypanosoma brucei proteasome beta 7 subunit 0.003 0.035 0.0407
Trichomonas vaginalis calmodulin, putative 0.0028 0.0299 0.043
Trypanosoma brucei Calpain-like protein 1.2 0.0055 0.0844 0.1693
Echinococcus multilocularis cysteine protease 0.0091 0.1555 0.1555
Toxoplasma gondii centrin, putative 0.0028 0.0299 0.0739
Plasmodium vivax proteasome subunit beta type-3, putative 0.003 0.035 0.0229
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.003 0.035 0.0198
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0055 0.0844 0.1695
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0113 0.0113
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.003 0.035 0.0549
Echinococcus multilocularis proteasome subunit beta type 7 0.003 0.035 0.035
Toxoplasma gondii proteasome beta subunit 0.003 0.035 0.0866
Brugia malayi Calmodulin-like protein 0.0028 0.0299 0.0316
Schistosoma mansoni neuronal calcium sensor 0.0028 0.0299 0.0188
Schistosoma mansoni gamma-secretase subunit aph-1 0.0143 0.2591 0.2509
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0844 0.1693
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.003 0.035 0.0407
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0055 0.0844 0.0823
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.003 0.035 0.0371
Onchocerca volvulus 0.0048 0.0695 0.0759
Trypanosoma brucei ATP-dependent protease subunit HslV 0.003 0.035 0.0407
Trypanosoma brucei calpain, putative 0.0055 0.0844 0.1693
Brugia malayi Papain family cysteine protease containing protein 0.0027 0.0277 0.0293
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0074 0.121 0.2543
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.003 0.035 0.0407
Brugia malayi proteasome subunit alpha type 4 0.003 0.035 0.0371
Leishmania major hypothetical protein, conserved 0.0028 0.0299 0.0274
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0113 0.012
Plasmodium vivax proteasome subunit alpha type-2, putative 0.003 0.035 0.0229
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0055 0.0844 0.2091
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.003 0.035 0.024
Trypanosoma cruzi cysteine protease, putative 0.0053 0.0795 0.076
Leishmania major hypothetical protein, conserved 0.0055 0.0844 0.1693
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.003 0.035 0.0407
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.003 0.035 0.0603
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0113 0.012
Brugia malayi 20S proteasome alpha5 subunit 0.003 0.035 0.0371
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0027 0.0277 0.0035
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0844 0.1693
Giardia lamblia Proteasome subunit beta type 7 precursor 0.003 0.035 0.0195
Leishmania major proteasome alpha 7 subunit, putative 0.003 0.035 0.0407
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0149 0.2698 0.5993
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0053 0.0795 0.069
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0028 0.0299 0.0473
Echinococcus multilocularis sarcoplasmic calcium binding protein 0.0028 0.0299 0.0299
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.003 0.035 0.0603
Brugia malayi cathepsin L precursor 0.0027 0.0277 0.0293
Echinococcus multilocularis calumenin 0.0028 0.0307 0.0307
Plasmodium vivax vivapain-2 0.0091 0.1555 0.3421
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.003 0.035 0.0407
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0091 0.1555 0.1647
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.003 0.035 0.0198
Onchocerca volvulus 0.0091 0.1555 0.2322
Echinococcus multilocularis Proteasome subunit alpha type 7 0.003 0.035 0.035
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0055 0.0844 0.0823
Plasmodium vivax proteasome subunit alpha type-6, putative 0.003 0.035 0.0229
Loa Loa (eye worm) hypothetical protein 0.0421 0.8107 0.859
Loa Loa (eye worm) EF hand family protein 0.0028 0.0299 0.0316
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0335 0.0335
Brugia malayi proteasome subunit alpha type 1 0.003 0.035 0.0371
Loa Loa (eye worm) hypothetical protein 0.0026 0.0263 0.0279
Trypanosoma cruzi centrin, putative 0.0028 0.0299 0.0133
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0844 0.1693
Brugia malayi hypothetical protein 0.0019 0.0113 0.012
Schistosoma mansoni reticulocalbin 0.0028 0.0299 0.0188
Trypanosoma brucei proteasome beta 6 subunit 0.0078 0.1291 0.2856
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.1555 0.3342
Leishmania major centrin, putative 0.0028 0.0299 0.0274
Trypanosoma cruzi I/6 autoantigen, putative 0.0028 0.0299 0.0133
Entamoeba histolytica calmodulin, putative 0.0028 0.0299 0.0473
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.003 0.035 0.0198
Giardia lamblia Proteasome subunit beta type 3 0.003 0.035 0.0195
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0027 0.0277 0.0035
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0844 0.0823
Onchocerca volvulus 0.0065 0.1037 0.1381
Loa Loa (eye worm) hypothetical protein 0.003 0.0335 0.0355
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0091 0.1555 0.3342
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.0299 0.0274
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.003 0.035 0.0371
Trichomonas vaginalis centrin, putative 0.0028 0.0299 0.043
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.003 0.035 0.0195
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.003 0.035 0.024
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0027 0.0277 0.0035
Brugia malayi Pre-SET motif family protein 0.0207 0.3859 0.4088
Brugia malayi Cathepsin L-like precursor 0.0091 0.1555 0.1647
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0074 0.121 0.121
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.003 0.035 0.024
Brugia malayi Proteasome subunit alpha type 1 0.003 0.035 0.0371
Echinococcus multilocularis cathepsin b 0.0421 0.8107 0.8107
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0078 0.1291 0.1387
Trichomonas vaginalis calcium binding protein, putative 0.0028 0.0299 0.043
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.003 0.035 0.0198
Brugia malayi proteasome subunit alpha type 2 0.003 0.035 0.0371
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0487 0.9438 0.944
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0074 0.121 0.2482
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.003 0.035 0.0198
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0053 0.0795 0.069
Schistosoma mansoni cathepsin s 0.0026 0.0263 0.0152
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.003 0.035 0.024
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.3859 0.4088
Loa Loa (eye worm) hypothetical protein 0.0026 0.0263 0.0279
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0844 0.1693
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0113 0.0113
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0844 0.0823
Toxoplasma gondii cathepsin B 0.0149 0.2698 0.6682
Brugia malayi calpain 5 0.0129 0.2302 0.2439
Toxoplasma gondii EFHC1, putative 0.0028 0.0299 0.0739
Brugia malayi proteasome subunit alpha type 6 0.003 0.035 0.0371
Leishmania major proteasome alpha 3 subunit, putative 0.003 0.035 0.0407
Echinococcus multilocularis EF hand domain containing family member A2 0.0028 0.0307 0.0307
Loa Loa (eye worm) fibroinase 0.0091 0.1555 0.1647
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0184 0.3402 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0277 0.0379
Echinococcus granulosus calpain 0.0184 0.3402 0.3402
Leishmania major cysteine peptidase A (CPA) 0.0091 0.1555 0.3541
Echinococcus multilocularis cathepsin b 0.0421 0.8107 0.8107
Plasmodium vivax serine-repeat antigen (SERA) 0.0027 0.0277 0.0035
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.003 0.035 0.0549
Echinococcus granulosus cathepsin l1 0.0091 0.1555 0.1555
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0078 0.1291 0.1291
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0028 0.0299 0.0473
Loa Loa (eye worm) ctsf protein 0.0091 0.1555 0.1647
Plasmodium falciparum centrin-1 0.0028 0.0299 0.0059
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0844 0.1693
Trypanosoma brucei proteasome beta-1 subunit, putative 0.003 0.035 0.0407
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.003 0.035 0.0603
Echinococcus granulosus Proteasome subunit alpha beta 0.003 0.035 0.035
Trypanosoma brucei cysteine peptidase C (CPC) 0.0149 0.2698 0.6515
Toxoplasma gondii proteasome subunit beta type, putative 0.0216 0.4038 1
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0055 0.0844 0.0823
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0335 0.0225
Leishmania major cathepsin L-like protease 0.0091 0.1555 0.3541
Echinococcus multilocularis subfamily T1A non peptidase ue 0.003 0.035 0.035
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.003 0.035 0.0407
Trypanosoma brucei hypothetical protein 0.0055 0.0844 0.1693
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0149 0.2698 0.3165
Trichomonas vaginalis calcium binding protein, putative 0.0028 0.0299 0.043
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0184 0.3402 0.8344
Leishmania major cathepsin L-like protease 0.0091 0.1555 0.3541
Loa Loa (eye worm) calpain 0.0184 0.3402 0.3604
Echinococcus multilocularis EF HAND 1, calcium binding site 0.0028 0.0299 0.0299
Brugia malayi hypothetical protein 0.0438 0.8448 0.8951
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0027 0.0277 0.0035
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.003 0.035 0.0195
Echinococcus granulosus programmed cell death protein 0.0028 0.0299 0.0299
Plasmodium vivax proteasome subunit beta type-5, putative 0.0216 0.4038 1
Trichomonas vaginalis calmodulin, putative 0.0028 0.0299 0.043
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.003 0.035 0.035
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0027 0.0277 0.0165
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0184 0.3402 0.8344
Brugia malayi Papain family cysteine protease containing protein 0.0053 0.0795 0.0842
Echinococcus granulosus EF hand domain containing family member A2 0.0028 0.0299 0.0299
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0028 0.0299 0.0133
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.003 0.035 0.0603
Schistosoma mansoni centrin 0.0028 0.0299 0.0188
Echinococcus multilocularis proteasome subunit beta type 6 0.003 0.035 0.035
Brugia malayi Cytochrome P450 family protein 0.0023 0.0193 0.0205
Trypanosoma brucei kinesin, putative 0.0129 0.2302 0.5485
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0277 0.0379
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0844 0.1693
Schistosoma mansoni hypothetical protein 0.0028 0.0299 0.0188
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0074 0.121 0.2645
Brugia malayi proteasome subunit beta type 1 0.0078 0.1291 0.1368
Trypanosoma brucei calpain-like protein, putative 0.0184 0.3402 0.8344
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0844 0.1695
Echinococcus multilocularis neuronal calcium sensor 0.0028 0.0299 0.0299
Leishmania major cathepsin L-like protease 0.0091 0.1555 0.3541
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0113 0.0113
Leishmania major calmodulin, putative 0.0028 0.0299 0.0274
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0421 0.8107 0.8092
Toxoplasma gondii proteasome subunit alpha type, putative 0.003 0.035 0.0866
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.2458 0.5891
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0184 0.3402 0.4054
Entamoeba histolytica cysteine protease, putative 0.0053 0.0795 0.1737
Echinococcus multilocularis proteasome subunit alpha type 6 0.003 0.035 0.035
Echinococcus granulosus cathepsin L 0.0027 0.0277 0.0277
Onchocerca volvulus 0.0091 0.1555 0.2322
Loa Loa (eye worm) hypothetical protein 0.0026 0.0263 0.0279
Loa Loa (eye worm) hypothetical protein 0.0019 0.0113 0.012
Trypanosoma brucei proteasome beta 2 subunit, putative 0.003 0.035 0.0407
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0091 0.1555 0.3398
Loa Loa (eye worm) cathepsin B 0.0149 0.2698 0.2859
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0184 0.3402 0.4054
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.003 0.035 0.0549
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0216 0.4038 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.1037 0.1098
Echinococcus multilocularis calpain 0.0184 0.3402 0.3402
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0184 0.3402 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0091 0.1555 0.3342
Toxoplasma gondii peptidase, T1 family protein 0.003 0.035 0.0866
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.003 0.035 0.0549
Brugia malayi calpain family protein 1 0.0487 0.9438 1
Leishmania major proteasome alpha 1 subunit, putative 0.003 0.035 0.0407
Onchocerca volvulus 0.0304 0.5782 1
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0055 0.0844 0.1693
Loa Loa (eye worm) hypothetical protein 0.0028 0.0299 0.0316
Brugia malayi Cytochrome P450 family protein 0.0023 0.0193 0.0205
Trypanosoma brucei centrin-3 0.0028 0.0299 0.0274
Trypanosoma cruzi cysteine peptidase, putative 0.0053 0.0795 0.076
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0113 0.012
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0027 0.0277 0.0379
Echinococcus granulosus calpain A 0.0184 0.3402 0.3402
Loa Loa (eye worm) proteasome subunit alpha type 2 0.003 0.035 0.0371
Echinococcus multilocularis hypothetical protein 0.0184 0.3402 0.3402
Plasmodium vivax proteasome subunit alpha type-3, putative 0.003 0.035 0.0229
Loa Loa (eye worm) hypothetical protein 0.0019 0.0113 0.012
Entamoeba histolytica cysteine protease, putative 0.0027 0.0277 0.0416
Giardia lamblia Proteasome subunit beta type 9 precursor 0.003 0.035 0.0195
Toxoplasma gondii cathepsin CPC1 0.0027 0.0277 0.0685
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0091 0.1555 0.3342
Trypanosoma cruzi calmodulin, putative 0.0028 0.0299 0.0133
Trypanosoma cruzi cruzipain precursor, putative 0.0026 0.0263 0.0088
Trypanosoma cruzi Aph-1 protein, putative 0.0056 0.0854 0.0835
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.1555 0.3342
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0027 0.0277 0.0165
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.003 0.035 0.0866
Echinococcus granulosus cathepsin L 0.0053 0.0795 0.0795
Echinococcus multilocularis cathepsin L cysteine protease 0.0091 0.1555 0.1555
Trichomonas vaginalis calmodulin, putative 0.0028 0.0307 0.0449
Trypanosoma cruzi cysteine peptidase, putative 0.0136 0.2458 0.2862
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.003 0.035 0.0549
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.003 0.035 0.024
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0844 0.0823
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.003 0.035 0.0603
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0027 0.0277 0.0165
Plasmodium vivax proteasome subunit beta type-6, putative 0.003 0.035 0.0229
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0027 0.0277 0.0035
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.003 0.035 0.024
Onchocerca volvulus Cathepsin L homolog 0.0091 0.1555 0.2322
Echinococcus multilocularis cathepsin L cysteine protease 0.0091 0.1555 0.1555
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0113 0.012
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.003 0.035 0.035
Leishmania major proteasome beta 3 subunit, putative 0.003 0.035 0.0407
Onchocerca volvulus 0.0091 0.1555 0.2322
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0055 0.0844 0.0823
Brugia malayi Papain family cysteine protease containing protein 0.0053 0.0795 0.0842
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0113 0.012
Schistosoma mansoni calpain (C02 family) 0.0184 0.3402 0.3329
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0335 0.0335
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.003 0.035 0.0198
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.003 0.035 0.0549
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0216 0.4038 0.4858
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0335 0.0225
Trichomonas vaginalis calpain, putative 0.0055 0.0844 0.1695
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.2458 0.5891
Loa Loa (eye worm) hypothetical protein 0.0027 0.0277 0.0293
Giardia lamblia 20S proteasome alpha subunit 7 0.003 0.035 0.0195
Leishmania major programmed cell death 6 protein-like protein 0.0028 0.0299 0.0274
Entamoeba histolytica cysteine protease, putative 0.0053 0.0795 0.1737
Onchocerca volvulus 0.0089 0.152 0.2259
Trypanosoma cruzi cysteine proteinase, putative 0.0053 0.0795 0.076
Plasmodium vivax proteasome subunit beta type-2, putative 0.0074 0.121 0.2509
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0149 0.2698 0.2617
Plasmodium vivax proteasome subunit beta type-1, putative 0.0078 0.1291 0.2723
Trypanosoma brucei antigen, putative 0.0184 0.3402 0.8344
Trypanosoma brucei I/6 autoantigen 0.0028 0.0299 0.0274
Plasmodium falciparum proteasome subunit beta type-4 0.003 0.035 0.0195
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0074 0.121 0.1285
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.003 0.035 0.0407
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0844 0.1693
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.1555 0.3342
Loa Loa (eye worm) calpain family protein 1 0.0359 0.6881 0.7291
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0113 0.0113
Plasmodium vivax calpain, putative 0.0184 0.3402 0.8313
Trichomonas vaginalis calmodulin, putative 0.0028 0.0299 0.043
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0091 0.1555 0.3342
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.003 0.035 0.0195
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0216 0.4038 1
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0216 0.4038 0.4858
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.003 0.035 0.035
Schistosoma mansoni calmodulin 0.0028 0.0299 0.0188
Toxoplasma gondii centrin 0.0028 0.0299 0.0739
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0945 0.1956
Plasmodium falciparum cysteine proteinase falcipain 3 0.0091 0.1555 0.3398
Leishmania major calmodulin-like protein 0.0028 0.0299 0.0274
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0184 0.3402 0.4054
Toxoplasma gondii proteasome subunit 0.003 0.035 0.0866
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0055 0.0844 0.0823
Trypanosoma cruzi calmodulin, putative 0.0028 0.0299 0.0133
Echinococcus granulosus cathepsin l cysteine peptidase 0.0091 0.1555 0.1555
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0277 0.0379
Plasmodium vivax vivapain-3 0.0053 0.0795 0.1408
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.003 0.035 0.0603
Plasmodium vivax SET domain protein, putative 0.003 0.0335 0.019
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.003 0.035 0.0198
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0113 0.0113
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0091 0.1555 0.3342
Trypanosoma brucei Calpain-like protein 1.1 0.0055 0.0844 0.1693
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.003 0.035 0.0198
Entamoeba histolytica cysteine protease, putative 0.0053 0.0795 0.1737
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0091 0.1555 0.3342
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0307 0.0115
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0216 0.4038 0.9099
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0143 0.2591 0.2746
Loa Loa (eye worm) proteasome subunit alpha type 3 0.003 0.035 0.0371
Echinococcus multilocularis calpain 7 (C02 family) 0.0184 0.3402 0.3402
Plasmodium falciparum proteasome subunit beta type-5 0.0216 0.4038 1
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.003 0.035 0.0407
Echinococcus granulosus calumenin 0.0028 0.0307 0.0307
Plasmodium vivax proteasome subunit alpha type-1, putative 0.003 0.035 0.0229
Brugia malayi Papain family cysteine protease containing protein 0.0027 0.0277 0.0293
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0113 0.0113
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0053 0.0795 0.069
Loa Loa (eye worm) AStacin protease 0.0025 0.0239 0.0254
Trypanosoma cruzi 20S proteasome subunit 0.0074 0.121 0.1285
Trichomonas vaginalis calmodulin, putative 0.0028 0.0299 0.043
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.003 0.035 0.5
Plasmodium falciparum proteasome subunit beta type-7, putative 0.003 0.035 0.0195
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0055 0.0844 0.1695
Giardia lamblia Cathepsin B precursor 0.0149 0.2698 0.6438
Loa Loa (eye worm) hypothetical protein 0.0048 0.0695 0.0736
Onchocerca volvulus Notchless protein homolog 0.003 0.035 0.0133
Trichomonas vaginalis calcium binding protein, putative 0.0028 0.0299 0.043
Leishmania major calcineurin B subunit, putative 0.0028 0.0299 0.0274
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0055 0.0844 0.0823
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0515 0.9992 1
Leishmania major phospholipase c-like protein 0.0028 0.0299 0.0274
Entamoeba histolytica cysteine proteinase 2 0.0053 0.0795 0.1737
Trichomonas vaginalis DNA-dependent protein kinase catalytic subunit-interacting protein, putative 0.0028 0.0299 0.043
Giardia lamblia Proteasome subunit beta type 4 precursor 0.003 0.035 0.0195
Trypanosoma brucei Aph-1 protein, putative 0.0056 0.0854 0.1719
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0091 0.1555 0.3342
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.003 0.035 0.0198
Trypanosoma cruzi major cysteine proteinase, putative 0.0027 0.0277 0.0105
Trichomonas vaginalis calpain, putative 0.0055 0.0844 0.1695
Leishmania major calpain protease-like protein 0.0055 0.0844 0.1693
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0216 0.4038 0.4279
Trichomonas vaginalis Crustacean calcium-binding protein, putative 0.0028 0.0299 0.043
Trypanosoma cruzi kinesin, putative 0.0129 0.2302 0.2665
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0091 0.1555 0.3342
Plasmodium falciparum proteasome subunit beta type-3, putative 0.003 0.035 0.0195
Schistosoma mansoni neuronal calcium sensor 0.0028 0.0299 0.0188
Schistosoma mansoni Mername-AA248 (C02 family) 0.0184 0.3402 0.3329
Echinococcus granulosus 20S proteasome subunit alpha 6 0.003 0.035 0.035
Brugia malayi hypothetical protein 0.0146 0.2646 0.2804
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0277 0.0379
Entamoeba histolytica calpain family cysteine protease, putative 0.0055 0.0844 0.1863
Entamoeba histolytica cysteine proteinase, putative 0.0053 0.0795 0.1737
Loa Loa (eye worm) hypothetical protein 0.0027 0.0277 0.0293
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.003 0.035 0.035
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 33 0.0028 0.0299 0.0274
Brugia malayi hypothetical protein 0.0019 0.0113 0.012
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0113 0.012
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.003 0.035 0.0198
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.1555 0.3342
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.003 0.035 0.0407
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.1555 0.3342
Echinococcus multilocularis calbindin 32 0.0028 0.0307 0.0307
Leishmania major protein kinase, putative 0.0028 0.0299 0.0274
Brugia malayi cathepsin F-like cysteine proteinase 0.0027 0.0277 0.0293
Leishmania major cathepsin L-like protease 0.0136 0.2458 0.5891
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0055 0.0844 0.1693
Entamoeba histolytica hypothetical protein, conserved 0.0028 0.0307 0.0493
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.2458 0.5891
Echinococcus granulosus sarcoplasmic calcium binding protein 0.0028 0.0299 0.0299
Schistosoma mansoni calpain-7 (C02 family) 0.0184 0.3402 0.3329
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0027 0.0277 0.0165
Leishmania major hypothetical protein, conserved 0.0028 0.0307 0.0295
Loa Loa (eye worm) hypothetical protein 0.0055 0.0844 0.0895
Loa Loa (eye worm) hypothetical protein 0.0438 0.8448 0.8951
Entamoeba histolytica grainin, putative 0.0028 0.0307 0.0493
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.1555 0.3342
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.003 0.035 0.0549
Echinococcus multilocularis proteasome subunit alpha type 2 0.003 0.035 0.035
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.003 0.035 0.0407
Brugia malayi Proteasome A-type and B-type family protein 0.003 0.035 0.0371
Echinococcus multilocularis cathepsin L 0.0053 0.0795 0.0795
Entamoeba histolytica cysteine protease, putative 0.0053 0.0795 0.1737
Schistosoma mansoni cathepsin F (C01 family) 0.0065 0.1037 0.0935
Schistosoma mansoni neuronal calcium sensor 0.0028 0.0299 0.0188
Brugia malayi Cathepsin L-like precursor 0.0091 0.1555 0.1647
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.003 0.035 0.035
Brugia malayi cathepsin F-like cysteine proteinase 0.0026 0.0263 0.0279
Echinococcus granulosus cysteine protease 0.0053 0.0795 0.0795
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0844 0.1693
Entamoeba histolytica cysteine protease, putative 0.0053 0.0795 0.1737
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0695 0.0589
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.003 0.035 0.0603
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0216 0.4038 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0053 0.0807 0.0855
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.004 0.0536 0.0428
Brugia malayi EF hand family protein 0.0028 0.0307 0.0325
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0421 0.8107 0.8092
Brugia malayi proteasome subunit alpha type 3 0.003 0.035 0.0371
Trichomonas vaginalis calmodulin, putative 0.0028 0.0299 0.043
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.1555 0.3342
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.003 0.035 0.0371
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0026 0.0263 0.0279
Brugia malayi calpain 7 0.0184 0.3402 0.3604
Leishmania major centrin, putative 0.0028 0.0299 0.0274
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0028 0.0299 0.0094
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0795 0.158
Echinococcus granulosus proteasome subunit alpha type 6 0.003 0.035 0.035
Onchocerca volvulus 0.0091 0.1555 0.2322
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0277 0.0379
Echinococcus granulosus cathepsin b 0.0421 0.8107 0.8107
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.003 0.035 0.0603
Schistosoma mansoni Sarcoplasmic calcium-binding protein (SCP). 0.0028 0.0299 0.0188
Leishmania major cathepsin L-like protease 0.0091 0.1555 0.3541
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.2458 0.5891
Leishmania major cathepsin L-like protease 0.0091 0.1555 0.3541
Echinococcus multilocularis cathepsin L 0.0027 0.0277 0.0277
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0113 0.0113
Loa Loa (eye worm) hypothetical protein 0.0432 0.8339 0.8835
Brugia malayi cathepsin B-like cysteine proteinase 0.0421 0.8107 0.859
Entamoeba histolytica proteasome subunit beta type 3, putative 0.003 0.035 0.0603
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0844 0.1693
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0945 0.0945
Loa Loa (eye worm) programmed cell death protein 6 0.0028 0.0307 0.0325
Onchocerca volvulus 0.0236 0.4432 0.7548
Entamoeba histolytica cysteine proteinase, putative 0.0091 0.1555 0.3673
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.2458 0.5891
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0027 0.0277 0.0165
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0055 0.0844 0.0823
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0277 0.0379
Echinococcus granulosus calmodulin 0.0028 0.0299 0.0299
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative 0.0028 0.0299 0.0274
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.003 0.035 0.0198
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0515 0.9992 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0335 0.0225
Brugia malayi Cathepsin L-like cysteine proteinase 0.0065 0.1037 0.1098
Trypanosoma cruzi kinesin, putative 0.0129 0.2302 0.2665
Leishmania major proteasome alpha 2 subunit, putative 0.003 0.035 0.0407
Schistosoma mansoni cathepsin C 0.0027 0.0277 0.0165
Trichomonas vaginalis calpain, putative 0.0055 0.0844 0.1695
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0299 0.043
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0055 0.0844 0.0823
Brugia malayi Pre-SET motif family protein 0.003 0.0335 0.0355
Schistosoma mansoni neuronal calcium sensor 0.0028 0.0299 0.0188
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0184 0.3402 0.4054
Leishmania major proteasome beta 7 subunit, putative 0.003 0.035 0.0407
Trypanosoma brucei calpain-like protein, putative 0.0184 0.3402 0.8344
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.1555 0.3342
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.003 0.035 0.0198
Brugia malayi follicle stimulating hormone receptor 0.0285 0.5418 0.574
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0945 0.0842
Trichomonas vaginalis calcineurin B subunit, putative 0.0028 0.0307 0.0449
Giardia lamblia 20S proteasome alpha subunit 1 0.003 0.035 0.0195
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0055 0.0844 0.1695
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.003 0.035 0.0549
Brugia malayi cathepsin L-like cysteine proteinase 0.0027 0.0277 0.0293
Onchocerca volvulus Cathepsin L homolog 0.0091 0.1555 0.2322
Echinococcus granulosus cathepsin L cysteine proteinase 0.0091 0.1555 0.1555
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.003 0.035 0.0195
Plasmodium vivax unspecified product 0.0027 0.0277 0.0035
Echinococcus granulosus proteasome subunit beta t family 0.003 0.035 0.035
Schistosoma mansoni cathepsin B (C01 family) 0.0027 0.0277 0.0165
Loa Loa (eye worm) hypothetical protein 0.0065 0.1037 0.1098
Echinococcus multilocularis calpain 5 0.0184 0.3402 0.3402
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0113 0.012
Loa Loa (eye worm) calmodulin-like protein 0.0028 0.0299 0.0316
Echinococcus multilocularis Tolloid protein 1 0.004 0.0536 0.0536
Brugia malayi PXA domain containing protein 0.0019 0.0113 0.012
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0074 0.121 0.1111
Trypanosoma brucei calmodulin, putative 0.0028 0.0299 0.0274
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0113 0.0113
Echinococcus granulosus tumor protein p63 0.0326 0.6232 0.6232
Loa Loa (eye worm) hypothetical protein 0.0016 0.0067 0.0071
Entamoeba histolytica cysteine protease, putative 0.0053 0.0795 0.1737
Trypanosoma cruzi calmodulin, putative 0.0028 0.0299 0.0133
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.2458 0.5891
Echinococcus granulosus expressed protein 0.036 0.6912 0.6912
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.1555 0.3342
Giardia lamblia 20S proteasome alpha subunit 3 0.003 0.035 0.0195
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0795 0.158
Brugia malayi EF hand family protein 0.0028 0.0299 0.0316
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0113 0.0113
Entamoeba histolytica cysteine protease, putative 0.0027 0.0277 0.0416
Brugia malayi Cathepsin L-like precursor 0.0091 0.1555 0.1647
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0027 0.0277 0.0379
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0113 0.0113
Schistosoma mansoni cathepsin F (C01 family) 0.0091 0.1555 0.1459
Trypanosoma cruzi cruzipain precursor, putative 0.0136 0.2458 0.2862
Plasmodium vivax serine-repeat antigen (SERA) 0.0027 0.0277 0.0035
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0027 0.0277 0.0379
Entamoeba histolytica cysteine proteinase, putative 0.0053 0.0795 0.1737
Giardia lamblia 20S proteasome alpha subunit 5 0.003 0.035 0.0195
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.003 0.035 0.0866
Trypanosoma brucei centrin, putative 0.0028 0.0299 0.0274
Entamoeba histolytica cysteine proteinase 1, putative 0.0053 0.0795 0.1737
Schistosoma mansoni calpain-2 (C02 family) 0.0055 0.0844 0.074
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0074 0.121 0.121
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.003 0.035 0.0229
Schistosoma mansoni survival motor neuron protein 0.0089 0.152 0.1424
Trichomonas vaginalis calmodulin, putative 0.0028 0.0299 0.043
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.2458 0.5891
Entamoeba histolytica hypothetical protein 0.0027 0.0277 0.0416
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0216 0.4038 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0091 0.1555 0.3342
Entamoeba histolytica grainin 2 0.0028 0.0299 0.0473
Echinococcus granulosus EF hand domain containing family member A2 0.0028 0.0307 0.0307
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.003 0.035 0.024
Loa Loa (eye worm) hypothetical protein 0.0027 0.0277 0.0293
Trypanosoma brucei calmodulin, putative 0.0028 0.0307 0.0295
Echinococcus granulosus Tolloid protein 1 0.004 0.0536 0.0536
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.003 0.035 0.0603
Trypanosoma brucei calpain, putative 0.0055 0.0844 0.1693
Mycobacterium ulcerans proteasome PrcB 0.0216 0.4038 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0277 0.0379
Brugia malayi PXA domain containing protein 0.0019 0.0113 0.012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0277 0.0379
Loa Loa (eye worm) hypothetical protein 0.0359 0.6881 0.7291
Leishmania major calmodulin-like protein 0.0028 0.0299 0.0274
Toxoplasma gondii EF hand domain-containing protein 0.0028 0.0299 0.0739
Echinococcus granulosus calpain 7 C02 family 0.0184 0.3402 0.3402
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0113 0.012
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0184 0.3402 0.4054
Loa Loa (eye worm) PAS-3 protein 0.003 0.035 0.0371

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 15.84893192 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 19.95262315 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 31.6227766 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 39.81071706 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (ADMET) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9. (Class of assay: confirmatory) [Related pubchem assays: 885, 884, 410 ] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (ADMET) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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