Detailed information for compound 1395374

Basic information

Technical information
  • TDR Targets ID: 1395374
  • Name: N-methyl-3-[3-(phenoxy)phenoxy]propan-1-amine ; oxalic acid
  • MW: 347.362 | Formula: C18H21NO6
  • H donors: 3 H acceptors: 4 LogP: 0.82 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C(=O)O.CNCCCOc1cccc(c1)Oc1ccccc1
  • InChi: 1S/C16H19NO2.C2H2O4/c1-17-11-6-12-18-15-9-5-10-16(13-15)19-14-7-3-2-4-8-14;3-1(4)2(5)6/h2-5,7-10,13,17H,6,11-12H2,1H3;(H,3,4)(H,5,6)
  • InChiKey: KZFZOQJNDXFCTB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • methyl-[3-[3-(phenoxy)phenoxy]propyl]amine; oxalic acid
  • ethanedioic acid; N-methyl-3-[3-(phenoxy)phenoxy]propan-1-amine
  • MLS000672251
  • N-methyl-3-(3-phenoxyphenoxy)-1-propanamine oxalate
  • SMR000293431

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0006 0.004
Echinococcus granulosus lysine specific demethylase 5A 0.0044 0.0054 0.0341
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0042 0.0264
Entamoeba histolytica hypothetical protein 0.0014 0.0006 0.004
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0011 0.0002 0.0008
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0021 0.0076
Schistosoma mansoni hypothetical protein 0.0035 0.0039 0.0247
Giardia lamblia Kinase, STE STE20 0.001 0.0000000024043 0.0000000088402
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0042 0.0266
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Brugia malayi Pre-SET motif family protein 0.0037 0.0042 0.0058
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0072 0.0451
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0 0.0002
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.002 0.0126
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.1013 0.1598 0.5874
Giardia lamblia Kinase, NEK-like 0.001 0.0000000024043 0.0000000088402
Giardia lamblia Kinase 0.001 0.0000000024043 0.0000000088402
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.001 0.0278
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0006 0.004
Loa Loa (eye worm) phosphatidylinositol 3 0.0014 0.0006 0.004
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0014 0.0006 0.004
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0014 0.0006 0.0023
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.002 0.0074
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0111 0.016 0.0589
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0014 0.0006 0.0023
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0014 0.0006 0.0023
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0006 0.004
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0021 0.0028
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0014 0.0006 0.0023
Trichomonas vaginalis harmonin-interacting ankyrin-repeat containing protein (harp), sans, putative 0.001 0.0000000024043 0.000000015049
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0071
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Mycobacterium tuberculosis Conserved protein 0.0036 0.0042 0.1186
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0014 0.0006 0.004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0006 0.004
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0006 0.004
Giardia lamblia Kinase, NEK-GL-like 0.001 0.0000000024043 0.0000000088402
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0021 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0006 0.004
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0072 0.0451
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0021 0.4895
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0014 0.0006 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0006 0.004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0006 0.004
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0152 0.0951
Schistosoma mansoni jumonji domain containing protein 0.0092 0.013 0.0813
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Schistosoma mansoni survival motor neuron protein 0.0058 0.0077 0.0481
Brugia malayi Bromodomain containing protein 0.0039 0.0046 0.0063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0006 0.004
Plasmodium falciparum phd finger protein, putative 0.0035 0.004 0.0147
Brugia malayi MH2 domain containing protein 0.0116 0.0168 0.0232
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.002 0.0126
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0006 0.004
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0013
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0459 0.0715 0.4475
Brugia malayi AF-10 protein 0.0012 0.0002 0.0003
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0152 0.0951
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0014 0.0006 0.004
Giardia lamblia Kinase, NEK-frag 0.001 0.0000000024043 0.0000000088402
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.0168 0.1049
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0473 0.0737 0.1015
Echinococcus granulosus glycogen synthase kinase 3 beta 0.1013 0.1598 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0021 0.0028
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Loa Loa (eye worm) hypothetical protein 0.0014 0.0006 0.004
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0014 0.0006 0.0023
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1718 0.272 1
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Trichomonas vaginalis esterase, putative 0.0036 0.0042 0.0264
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Schistosoma mansoni cpg binding protein 0.0029 0.003 0.0186
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.0042 0.0266
Leishmania major phosphatidylinositol 3-kinase, putative 0.0062 0.0082 0.0302
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0014 0.0006 0.0023
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Toxoplasma gondii FATC domain-containing protein 0.0014 0.0006 0.0023
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Brugia malayi Pre-SET motif family protein 0.0252 0.0385 0.053
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0014 0.0006 0.004
Giardia lamblia Kinase, NEK-frag 0.001 0.0000000024043 0.0000000088402
Giardia lamblia Kinase, NEK-frag 0.001 0.0000000024043 0.0000000088402
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0006 0.004
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0011 0.2699
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0014 0.0006 0.0023
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0062 0.0082 0.0514
Schistosoma mansoni phosphatidylserine receptor 0.0011 0.0002 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0006 0.004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0006 0.004
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0042 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.001 0.0278
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0021 0.0129
Trypanosoma brucei protein kinase, putative 0.1013 0.1598 0.5874
Loa Loa (eye worm) histone methyltransferase 0.001 0 0.0002
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0 0.0002
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0473 0.0737 0.271
Trypanosoma cruzi polo-like protein kinase, putative 0.0105 0.0152 0.0559
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0014 0.0006 0.0023
Loa Loa (eye worm) phosphatidylinositol 3 0.0144 0.0214 0.1337
Brugia malayi intracellular kinase 0.1013 0.1598 0.2199
Brugia malayi beta-lactamase family protein 0.0036 0.0042 0.0058
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.004 0.0147
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0062 0.0082 0.0514
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0062 0.0082 0.0113
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0042 0.0264
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0014 0.0006 0.004
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0062 0.0082 0.0514
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.002 0.0074
Echinococcus granulosus serine protein kinase ATM 0.0014 0.0006 0.004
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0014 0.0006 0.004
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0014 0.0006 0.0023
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0042 0.0266
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0039 0.0054
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0006 0.004
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0014 0.0006 0.0023
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0014 0.0006 0.0023
Echinococcus granulosus jumonji domain containing 1A 0.0011 0.0002 0.0013
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0047 0.0173
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0072 0.0099
Plasmodium falciparum JmjC domain-containing protein, putative 0.0011 0.0002 0.0008
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0077 0.0106
Schistosoma mansoni jumonji/arid domain-containing protein 0.0044 0.0054 0.0341
Onchocerca volvulus 0.0023 0.0021 0.0021
Giardia lamblia PHD finger protein 15 0.0035 0.004 0.0147
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0006 0.004
Entamoeba histolytica hypothetical protein 0.0014 0.0006 0.004
Echinococcus multilocularis serine protein kinase ATM 0.0014 0.0006 0.004
Mycobacterium ulcerans hypothetical protein 0.0036 0.0042 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0039 0.0246
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.002 0.0074
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0039 0.0247
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0014 0.0006 0.004
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0039 0.0247
Echinococcus granulosus cpg binding protein 0.003 0.0032 0.0202
Echinococcus granulosus dnaJ subfamily B 0.0408 0.0634 0.3967
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0021 0.4895
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0014 0.0006 0.004
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0105 0.0152 0.0559
Giardia lamblia Kinase, NEK-frag 0.001 0.0000000024043 0.0000000088402
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0071
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Loa Loa (eye worm) phosphatidylinositol 3 0.0014 0.0006 0.004
Schistosoma mansoni kinase 0.0058 0.0077 0.0482
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Brugia malayi F/Y-rich N-terminus family protein 0.0022 0.0018 0.0025
Brugia malayi Protein kinase domain containing protein 0.001 0.0000000024043 0.0000000033098
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0014 0.0006 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0006 0.004
Loa Loa (eye worm) hypothetical protein 0.0011 0.0002 0.0013
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Echinococcus granulosus microtubule associated protein 2 0.0669 0.1049 0.6568
Loa Loa (eye worm) hypothetical protein 0.0014 0.0006 0.004
Brugia malayi jmjC domain containing protein 0.0011 0.0002 0.0003
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0012 0.0002 0.0009
Trichomonas vaginalis TKL family protein kinase 0.001 0.0000000024043 0.000000015049
Onchocerca volvulus 0.0036 0.0042 0.0042
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0014 0.0006 0.0023
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0062 0.0082 0.0514
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.01 0.0625
Schistosoma mansoni hypothetical protein 0.0035 0.0039 0.0247
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0006 0.004
Trypanosoma cruzi polo-like protein kinase, putative 0.0105 0.0152 0.0559
Loa Loa (eye worm) phosphatidylinositol 3 0.0014 0.0006 0.004
Echinococcus granulosus lysine specific demethylase 6a 0.0011 0.0002 0.0013
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Giardia lamblia GTOR 0.0014 0.0006 0.0023
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.1013 0.1598 0.5874
Schistosoma mansoni microtubule-associated protein tau 0.0669 0.1049 0.6568
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0168 0.1054
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0072 0.0451
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0039 0.0054
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0042 0.1186
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0042 0.0264
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0473 0.0737 0.4614
Plasmodium vivax hypothetical protein, conserved 0.0035 0.004 0.0147
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.0042 0.0156
Giardia lamblia Kinase, NEK-frag 0.001 0.0000000024043 0.0000000088402
Echinococcus multilocularis geminin 0.0205 0.031 0.1939
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0473 0.0737 0.4614
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.011 0.0159 0.0219
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.0439 0.2746
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0152 0.0951
Brugia malayi latrophilin 2 splice variant baaae 0.0075 0.0104 0.0143
Onchocerca volvulus 0.0014 0.0006 0.0006
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0014 0.0006 0.004
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0014 0.0006 0.0023
Toxoplasma gondii exonuclease III APE 0.0023 0.002 0.0074
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0011 0.0002 0.0008
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0228 0.0347 0.1278
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Mycobacterium ulcerans lipase LipD 0.0036 0.0042 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0039 0.0247
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0006 0.004
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.004 0.0251
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0006 0.004
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0011 1
Plasmodium falciparum glycogen synthase kinase 3 0.1013 0.1598 0.5874
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0042 0.0155
Trichomonas vaginalis CMGC family protein kinase 0.1013 0.1598 1
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0062 0.0082 0.0514
Trichomonas vaginalis TKL family protein kinase 0.001 0.0000000024043 0.000000015049
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0062 0.0082 0.0302
Schistosoma mansoni hypothetical protein 0.0012 0.0002 0.0015
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0042 0.0058
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0062 0.0082 0.0514
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0006 0.004
Leishmania major phosphatidylinositol 4-kinase, putative 0.0014 0.0006 0.0023
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0062 0.0082 0.0302
Loa Loa (eye worm) hypothetical protein 0.0035 0.0039 0.0247
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0011 0.032
Loa Loa (eye worm) jmjC domain-containing protein 0.0011 0.0002 0.0013
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0011 0.0042
Trypanosoma brucei telomerase reverse transcriptase 0.1718 0.272 1
Mycobacterium ulcerans hypothetical protein 0.0023 0.0021 0.4895
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0042 0.0155
Brugia malayi Telomerase reverse transcriptase 0.4572 0.7264 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0044 0.0054 0.0341
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0014 0.0006 0.0009
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0042 0.1186
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0014 0.0006 0.004
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0042 0.0264
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.001 0.0278
Giardia lamblia Kinase, NEK-frag 0.001 0.0000000024043 0.0000000088402
Schistosoma mansoni phd/f-box containing protein 0.0011 0.0002 0.0013
Schistosoma mansoni hypothetical protein 0.0035 0.0039 0.0247
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0473 0.0737 0.4614
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0006 0.004
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Onchocerca volvulus 0.0058 0.0077 0.0077
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0021 0.4895
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.004 0.0251
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0006 0.004
Schistosoma mansoni serine/threonine protein kinase 0.0105 0.0152 0.0951
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0006 0.004
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0014 0.0006 0.0009
Brugia malayi beta-lactamase family protein 0.0036 0.0042 0.0058
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.002 0.0126
Brugia malayi jmjC domain containing protein 0.0011 0.0002 0.0003
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0105 0.0152 0.0951
Schistosoma mansoni cpg binding protein 0.003 0.0032 0.0202
Leishmania major hypothetical protein, conserved 0.0036 0.0042 0.0155
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.0052 0.0325
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0006 0.004
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0152 0.0951
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Trichomonas vaginalis CMGC family protein kinase 0.1013 0.1598 1
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0014 0.0006 0.004
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.002 0.0074
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0072 0.0451
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0053 0.0194
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.004 0.0251
Giardia lamblia Telomerase catalytic subunit 0.1718 0.272 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.002 0.0074
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0014 0.0006 0.0023
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0158 0.0236 0.0325
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0006 0.004
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0021 0.0581
Giardia lamblia Kinase, NEK-frag 0.001 0.0000000024043 0.0000000088402
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Brugia malayi Protein kinase domain containing protein 0.001 0.0000000024043 0.0000000033098
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.002 0.0568
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0014 0.0006 0.0023
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0062 0.0082 0.0514
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Entamoeba histolytica protein kinase domain containing protein 0.1013 0.1598 1
Giardia lamblia Kinase, NEK-frag 0.001 0.0000000024043 0.0000000088402
Leishmania major hypothetical protein, conserved 0.0014 0.0006 0.0023
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0014 0.0006 0.0023
Plasmodium vivax hypothetical protein, conserved 0.0014 0.0006 0.0023
Entamoeba histolytica hypothetical protein 0.0376 0.0583 0.3651
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0014 0.0006 0.0023
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0042 0.0264
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Plasmodium vivax hypothetical protein 0.0014 0.0006 0.0023
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0042 0.0264
Echinococcus granulosus GPCR family 2 0.0035 0.0039 0.0247
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0013 0.0005 0.003
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0252 0.0385 0.2411
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0053 0.0331
Mycobacterium leprae Probable lipase LipE 0.0036 0.0042 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.0042 0.0266
Brugia malayi jmjC domain containing protein 0.0044 0.0054 0.0075
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0021 0.0076
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0071
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0042 0.1186
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0072 0.0451
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0021 0.0581
Loa Loa (eye worm) hypothetical protein 0.0023 0.0021 0.0129
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Giardia lamblia Kinase, NEK-frag 0.001 0.0000000024043 0.0000000088402
Leishmania major telomerase reverse transcriptase, putative 0.1718 0.272 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0014 0.0006 0.0023
Brugia malayi jmjC domain containing protein 0.0011 0.0002 0.0003
Plasmodium vivax telomerase reverse transcriptase, putative 0.1718 0.272 1
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0042 0.0264
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0062 0.0082 0.0514
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0062 0.0082 0.0514
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.0439 0.2746
Toxoplasma gondii target of rapamycin (TOR), putative 0.0014 0.0006 0.0023
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Schistosoma mansoni ap endonuclease 0.0023 0.002 0.0126
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0152 0.0951
Schistosoma mansoni mixed-lineage leukemia protein mll 0.002 0.0016 0.0099
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0014 0.0006 0.004
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Echinococcus multilocularis 0.0014 0.0006 0.004
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.002 0.0074
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0306 0.0472 0.2953
Echinococcus granulosus protein kinase shaggy 0.1013 0.1598 1
Schistosoma mansoni hypothetical protein 0.0205 0.031 0.1939
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0144 0.0214 0.0786
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0014 0.0006 0.0009
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0014 0.0006 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0006 0.004
Giardia lamblia Kinase, NEK-like 0.001 0.0000000024043 0.0000000088402
Schistosoma mansoni fkbp-rapamycin associated protein 0.0014 0.0006 0.004
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0039 0.0247
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0006 0.004
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.001 0.0278
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0013 0.0005 0.0019
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0105 0.0152 0.0951
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0042 1
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Plasmodium vivax SET domain protein, putative 0.0037 0.0042 0.0156
Loa Loa (eye worm) phosphatidylinositol 3 0.0376 0.0583 0.3651
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0014 0.0006 0.0023
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0072 0.0451
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0264
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0062 0.0082 0.0302
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0014 0.0006 0.0023
Giardia lamblia Kinase, NEK-frag 0.001 0.0000000024043 0.0000000088402
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0042 0.1186
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.1543 0.966
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0014 0.0006 0.0023
Entamoeba histolytica protein kinase domain containing protein 0.1013 0.1598 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.0104 0.0649
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0014 0.0006 0.004
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0042 0.1186
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.004 0.0147
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0473 0.0737 0.4614
Giardia lamblia Kinase, NEK-frag 0.001 0.0000000024043 0.0000000088402
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.002 0.0126
Entamoeba histolytica hypothetical protein 0.0014 0.0006 0.004
Loa Loa (eye worm) phosphatidylinositol 3 0.0014 0.0006 0.004
Trichomonas vaginalis CAMK family protein kinase 0.0057 0.0075 0.0469
Brugia malayi jmjC domain containing protein 0.0011 0.0002 0.0003
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0062 0.0388
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0014 0.0006 0.0023
Brugia malayi acetyltransferase, GNAT family protein 0.0147 0.0218 0.03
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.004 0.0251
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.002 0.0126
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0021 0.0076
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0005 0.0019
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0147 0.0218 0.1364
Echinococcus multilocularis peregrin 0.0039 0.0046 0.0287
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0014 0.0006 0.004
Loa Loa (eye worm) hypothetical protein 0.0286 0.0439 0.2746
Plasmodium vivax glycogen synthase kinase 3, putative 0.1013 0.1598 0.5874
Giardia lamblia Hypothetical protein 0.0014 0.0006 0.0023
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0021 0.0129
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0473 0.0737 0.4614
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Schistosoma mansoni hypothetical protein 0.0035 0.0039 0.0247
Brugia malayi serine/threonine-protein kinase plk-2 0.0105 0.0152 0.0209
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0047 0.0173
Schistosoma mansoni ap endonuclease 0.0023 0.002 0.0126
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Toxoplasma gondii RNA-directed DNA polymerase 0.1718 0.272 1
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0014 0.0006 0.004
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0062 0.0082 0.0302
Loa Loa (eye worm) hypothetical protein 0.0035 0.004 0.0251
Loa Loa (eye worm) CMGC/GSK protein kinase 0.1013 0.1598 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0042 0.1186
Mycobacterium leprae conserved hypothetical protein 0.0014 0.0006 0.1501
Schistosoma mansoni hypothetical protein 0.0075 0.0104 0.0649
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0264
Giardia lamblia Kinase, CMGC GSK 0.1013 0.1598 0.5874
Trichomonas vaginalis TKL family protein kinase 0.001 0.0000000024043 0.000000015049
Leishmania major hypothetical protein, unknown function 0.0014 0.0006 0.0023
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0042 0.1186
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0147 0.0218 0.1364
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0006 0.004
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0078 0.0288
Schistosoma mansoni hypothetical protein 0.0058 0.0077 0.0481
Onchocerca volvulus 0.0014 0.0006 0.0006
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0039 0.0247
Loa Loa (eye worm) phosphatidylinositol kinase 0.0014 0.0006 0.004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0006 0.004
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0014 0.0006 0.0023
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.002 0.4791
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0014 0.0006 0.0023
Trichomonas vaginalis TKL family protein kinase 0.001 0.0000000024043 0.000000015049
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0376 0.0583 0.3651
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0014 0.0006 0.0023
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0014 0.0006 0.004
Loa Loa (eye worm) CMGC/GSK protein kinase 0.1013 0.1598 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0105 0.0152 0.0951
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0158 0.0236 0.1477
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0006 0.004
Giardia lamblia Kinase, CMGC GSK 0.1013 0.1598 0.5874
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0053 0.0331
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0014 0.0006 0.0023
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0014 0.0006 0.004
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0014 0.0006 0.0023
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0006 0.004
Schistosoma mansoni hypothetical protein 0.0014 0.0006 0.004
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0042 0.0266
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0152 0.0951
Onchocerca volvulus 0.0029 0.003 0.003
Brugia malayi PHD-finger family protein 0.0013 0.0005 0.0007
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Echinococcus multilocularis lysine specific demethylase 6a 0.0011 0.0002 0.0013
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0042 0.0266
Echinococcus multilocularis cpg binding protein 0.003 0.0032 0.0202
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0014 0.0006 0.004
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0037 0.0042 0.0266
Loa Loa (eye worm) hypothetical protein 0.0023 0.0021 0.0129
Giardia lamblia Kinase, NEK-frag 0.001 0.0000000024043 0.0000000088402
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.002 0.5
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0473 0.0737 0.271
Echinococcus multilocularis Zinc finger, PHD finger 0.0062 0.0082 0.0514
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Trypanosoma cruzi target of rapamycin kinase 3 0.0014 0.0006 0.0023
Schistosoma mansoni hypothetical protein 0.0205 0.031 0.1939
Leishmania major phosphatidylinositol 3-kinase, putative 0.0014 0.0006 0.0023
Loa Loa (eye worm) hypothetical protein 0.0037 0.0042 0.0266
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.002 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0006 0.004
Onchocerca volvulus Serine\/threonine kinase homolog 0.0105 0.0152 0.0152
Brugia malayi Calcitonin receptor-like protein seb-1 0.011 0.0159 0.0219
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0014 0.0006 0.0023
Schistosoma mansoni jumonji domain containing protein 0.0011 0.0002 0.0013
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0071
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1718 0.272 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0006 0.004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0006 0.004
Onchocerca volvulus Alhambra homolog 0.0035 0.004 0.004
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0011 0.0002 0.0008
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0021 0.0129
Echinococcus granulosus phd:f box containing protein 0.0011 0.0002 0.0013
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0047 0.0295
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0012 0.0002 0.0009
Echinococcus multilocularis jumonji domain containing 1A 0.0011 0.0002 0.0013
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0021 0.4895
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0264
Leishmania major phosphatidylinositol kinase, putative 0.0014 0.0006 0.0023
Trypanosoma brucei polo-like protein kinase 0.0105 0.0152 0.0559
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0473 0.0737 0.4614
Giardia lamblia Phosphatidylinositol 4-kinase 0.0014 0.0006 0.0023
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0233 0.0355 1
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0012 0.0002 0.0009
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0325 0.0501 0.3138
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0011 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0006 0.004
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0062 0.0388
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0014 0.0006 0.0023
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0014 0.0006 0.004
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0042 0.0155
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0168 0.1054
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0473 0.0737 0.4614
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0325 0.0501 0.3138
Onchocerca volvulus 0.0036 0.0042 0.0042
Schistosoma mansoni hypothetical protein 0.0035 0.004 0.0251
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0158 0.0236 0.1477
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0014 0.0006 0.0023
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0152 0.0951
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0021 0.4895
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0264
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0006 0.004
Loa Loa (eye worm) beta-lactamase 0.0036 0.0042 0.0264
Loa Loa (eye worm) hypothetical protein 0.011 0.0159 0.0996
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0006 0.004
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0042 0.0264
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0158 0.0236 0.1477
Echinococcus multilocularis phd:f box containing protein 0.0011 0.0002 0.0013
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Echinococcus multilocularis GPCR, family 2 0.0035 0.0039 0.0247
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0014 0.0006 0.004
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0053 0.0194
Onchocerca volvulus 0.1013 0.1598 0.1598
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.002 0.5
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0264
Loa Loa (eye worm) hypothetical protein 0.0023 0.0021 0.0129
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0006 0.004
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0158 0.0236 0.1477
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0306 0.0472 0.065
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0014 0.0006 0.0009
Leishmania major hypothetical protein, conserved 0.0011 0.0002 0.0008
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0062 0.0082 0.0514
Onchocerca volvulus 0.0037 0.0042 0.0042
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0014 0.0006 0.0023
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0014 0.0006 0.004
Schistosoma mansoni cpg binding protein 0.003 0.0032 0.0202
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0014 0.0006 0.004
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0014 0.0006 0.0023
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0072 0.0451
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0062 0.0082 0.0302
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0083 0.0519
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.003 0.0186
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Leishmania major phosphatidylinositol kinase related protein, putative 0.0014 0.0006 0.0023
Loa Loa (eye worm) hypothetical protein 0.0014 0.0006 0.004
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0013 0.0005 0.003
Loa Loa (eye worm) TKL/LRRK protein kinase 0.001 0.0000000024043 0.000000015049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0006 0.004
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Loa Loa (eye worm) acetyltransferase 0.0147 0.0218 0.1364
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0158 0.0236 0.1477
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0014 0.0006 0.004
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0053 0.0331
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0006 0.004
Mycobacterium ulcerans beta-lactamase 0.0036 0.0042 1
Giardia lamblia Kinase, PLK 0.0105 0.0152 0.0559
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0158 0.0236 0.0868
Schistosoma mansoni jumonji/arid domain-containing protein 0.0044 0.0054 0.0341
Onchocerca volvulus 0.0287 0.0441 0.0441
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.0168 0.1049
Brugia malayi PHD-finger family protein 0.0035 0.004 0.0055
Echinococcus multilocularis dnaJ subfamily B 0.0408 0.0634 0.3967
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0014 0.0006 0.0009
Plasmodium falciparum telomerase reverse transcriptase 0.1718 0.272 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0014 0.0006 0.0009
Echinococcus granulosus JmjC domain containing protein 4 0.0011 0.0002 0.0013
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0014 0.0006 0.004
Echinococcus multilocularis microtubule associated protein 2 0.0669 0.1049 0.6568
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0021 0.4895
Onchocerca volvulus 0.0036 0.0042 0.0042
Echinococcus multilocularis protein kinase shaggy 0.1013 0.1598 1
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0011 0.0002 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0006 0.004
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0062 0.0082 0.0302
Brugia malayi hypothetical protein 0.0286 0.0439 0.0604
Loa Loa (eye worm) jmjC domain-containing protein 0.0011 0.0002 0.0013
Trichomonas vaginalis CAMK family protein kinase 0.0057 0.0075 0.0469
Giardia lamblia Kinase, NEK-like 0.001 0.0000000024043 0.0000000088402
Loa Loa (eye worm) hypothetical protein 0.0167 0.0249 0.1561
Entamoeba histolytica hypothetical protein 0.0014 0.0006 0.004
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0014 0.0006 0.004
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0062 0.0082 0.0302
Toxoplasma gondii PHD-finger domain-containing protein 0.0012 0.0002 0.0009
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0021 0.4895
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0042 0.0155
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.021 0.0318 0.199
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0042 1
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.002 0.0074
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0158 0.0236 0.0868
Brugia malayi beta-lactamase 0.0036 0.0042 0.0058
Echinococcus granulosus histone acetyltransferase KAT2B 0.0143 0.0211 0.1323
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.1013 0.1598 1
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Plasmodium vivax JmjC domain containing protein 0.0011 0.0002 0.0008
Schistosoma mansoni hypothetical protein 0.0408 0.0634 0.3967
Entamoeba histolytica protein kinase rad3, putative 0.0014 0.0006 0.004
Entamoeba histolytica serine/threonine protein kinase, putative 0.0105 0.0152 0.0951
Loa Loa (eye worm) phosphatidylinositol 3 0.0014 0.0006 0.004
Loa Loa (eye worm) phosphatidylinositol 3 0.0014 0.0006 0.004
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.002 0.0126
Giardia lamblia Kinase, NEK-like 0.001 0.0000000024043 0.0000000088402
Loa Loa (eye worm) hypothetical protein 0.0306 0.0472 0.2953
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0042 0.0264
Brugia malayi jmjC domain containing protein 0.0115 0.0168 0.0231
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0071
Giardia lamblia Kinase, NEK-like 0.001 0.0000000024043 0.0000000088402
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0072 0.0451
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0158 0.0236 0.1477
Echinococcus granulosus geminin 0.0205 0.031 0.1939
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.1013 0.1598 1
Mycobacterium tuberculosis Conserved protein 0.0036 0.0042 0.1186
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0042 0.0264
Echinococcus granulosus peregrin 0.0039 0.0046 0.0287
Mycobacterium tuberculosis Conserved hypothetical protein 0.0014 0.0006 0.0178
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0062 0.0082 0.0514
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0021 0.4895
Entamoeba histolytica protein kinase, putative 0.1013 0.1598 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0011 0.0002 0.0013
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0006 0.004
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0011 0.0002 0.0008
Mycobacterium tuberculosis Conserved protein 0.0036 0.0042 0.1186
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0306 0.0472 0.2953
Brugia malayi CXXC zinc finger family protein 0.0029 0.003 0.0041
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0021 0.4895
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0062 0.0082 0.0302
Loa Loa (eye worm) pigment dispersing factor receptor c 0.011 0.0159 0.0996
Echinococcus multilocularis JmjC domain containing protein 4 0.0011 0.0002 0.0013
Loa Loa (eye worm) hypothetical protein 0.001 0.0000000024043 0.000000015049
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0053 0.0194
Giardia lamblia Kinase, NEK-frag 0.001 0.0000000024043 0.0000000088402
Schistosoma mansoni protein phosphatase 2C 0.0011 0.0002 0.0013
Trichomonas vaginalis set domain proteins, putative 0.0287 0.0441 0.2757
Loa Loa (eye worm) hypothetical protein 0.006 0.008 0.0502
Giardia lamblia Kinase, NEK 0.001 0.0000000024043 0.0000000088402
Loa Loa (eye worm) hypothetical protein 0.0036 0.0042 0.0264
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0011 0.0002 0.0008
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.1013 0.1598 0.5874
Toxoplasma gondii ABC1 family protein 0.0036 0.0042 0.0155

Activities

Activity type Activity value Assay description Source Reference
AC50 (binding) 20 uM PubChem BioAssay. Development of Small Molecule Probes of the Histone Methyltransferase, NSD2 Measured in Biochemical System Using Plate Reader - 7053-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.0007 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.6513 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.5849 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 2.6169 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3489 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 20.7865 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 22.3342 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: Inhibitors of TCP-1 ring complex (TRiC) of Methanococcus maripaludis (MmCpn): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488991] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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