Detailed information for compound 1399685

Basic information

Technical information
  • TDR Targets ID: 1399685
  • Name: 2-[(3,5-dimethyl-1,2-oxazol-4-yl)methylsulfan yl]-3-phenylquinazolin-4-one
  • MW: 363.433 | Formula: C20H17N3O2S
  • H donors: 0 H acceptors: 2 LogP: 4.12 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1onc(c1CSc1nc2ccccc2c(=O)n1c1ccccc1)C
  • InChi: 1S/C20H17N3O2S/c1-13-17(14(2)25-22-13)12-26-20-21-18-11-7-6-10-16(18)19(24)23(20)15-8-4-3-5-9-15/h3-11H,12H2,1-2H3
  • InChiKey: NVNUSCJXNKOLAV-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 2-[(3,5-dimethylisoxazol-4-yl)methylsulfanyl]-3-phenyl-quinazolin-4-one
  • 2-[(3,5-dimethyl-4-isoxazolyl)methylthio]-3-phenyl-4-quinazolinone
  • 2-[(3,5-dimethylisoxazol-4-yl)methylthio]-3-phenyl-quinazolin-4-one
  • 2-[(3,5-dimethyl-1,2-oxazol-4-yl)methylsulfanyl]-3-phenyl-quinazolin-4-one
  • SMR000062095
  • T0512-9026
  • ZINC03256659
  • MLS000057109

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens phospholipase A2, group IB (pancreas) Starlite/ChEMBL No references
Homo sapiens autophagy related 4B, cysteine peptidase Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens mitogen-activated protein kinase 1 Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G Starlite/ChEMBL No references
Homo sapiens glucosidase, beta, acid Starlite/ChEMBL No references
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana AUT2/APG4/ATG4 cysteine peptidase, putative,cysteine peptidase, Clan CA, family C54, putative Get druggable targets OG5_127111 All targets in OG5_127111
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Cryptosporidium parvum MAPK, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni family C54 unassigned peptidase (C54 family) Get druggable targets OG5_127111 All targets in OG5_127111
Leishmania infantum mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania donovani AUT2/APG4/ATG4 cysteine peptidase, putative Get druggable targets OG5_127111 All targets in OG5_127111
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative Get druggable targets OG5_127111 All targets in OG5_127111
Onchocerca volvulus Phospholipase A2 homolog Get druggable targets OG5_134661 All targets in OG5_134661
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis Peptidase C54 Get druggable targets OG5_127111 All targets in OG5_127111
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma brucei gambiense protein kinase, putative,tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis AUT2/APG4/ATG4 cysteine peptidase, putative Get druggable targets OG5_127111 All targets in OG5_127111
Schistosoma japonicum ko:K08342 autophagy-related protein 4, putative Get druggable targets OG5_127111 All targets in OG5_127111
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans MAP kinase implicated in PKC1-controlled signalling pathway Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus granulosus cysteine protease atg4b Get druggable targets OG5_127111 All targets in OG5_127111
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase Get druggable targets OG5_127111 All targets in OG5_127111
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase Get druggable targets OG5_127111 All targets in OG5_127111
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Echinococcus multilocularis mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma cruzi mitogen activated protein kinase 2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni autophagin-1 (C54 family) Get druggable targets OG5_127111 All targets in OG5_127111
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Candida albicans potential protease similar to S. cerevisiae ATG4 (YNL223W) microtubule-binding anchor protein involved in attachment of autophag Get druggable targets OG5_127111 All targets in OG5_127111
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus Peptidase C54 Get druggable targets OG5_127111 All targets in OG5_127111
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana mitogen-activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Giardia lamblia Kinase, CMGC MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K08342 autophagy-related protein 4, putative Get druggable targets OG5_127111 All targets in OG5_127111
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_134661 All targets in OG5_134661
Trypanosoma brucei mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative Get druggable targets OG5_127111 All targets in OG5_127111
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein Get druggable targets OG5_129423 All targets in OG5_129423
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni family C54 unassigned peptidase (C54 family) Get druggable targets OG5_127111 All targets in OG5_127111
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense mitogen-activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma congolense AUT2/APG4/ATG4 cysteine peptidase, putative Get druggable targets OG5_127111 All targets in OG5_127111
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Candida albicans potential protease similar to S. cerevisiae ATG4 (YNL223W) microtubule-binding anchor protein involved in attachment of autophag Get druggable targets OG5_127111 All targets in OG5_127111
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani mitogen-activated protein kinase 4 Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase Get druggable targets OG5_127111 All targets in OG5_127111
Schistosoma japonicum ko:K04371 extracellular signal-regulated kinase 1/2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127111 All targets in OG5_127111
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi O-Glycosyl hydrolase family 30 protein Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase Get druggable targets OG5_127111 All targets in OG5_127111
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei gambiense peptidase, putative Get druggable targets OG5_127111 All targets in OG5_127111
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei AUT2/APG4/ATG4 cysteine peptidase, putative Get druggable targets OG5_127111 All targets in OG5_127111
Onchocerca volvulus Glucosylceramidase homolog Get druggable targets OG5_129423 All targets in OG5_129423
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi Peptidase family C54 containing protein Get druggable targets OG5_127111 All targets in OG5_127111
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase Get druggable targets OG5_127111 All targets in OG5_127111
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis cysteine protease atg4b Get druggable targets OG5_127111 All targets in OG5_127111
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Leishmania infantum AUT2/APG4/ATG4 cysteine peptidase, putative Get druggable targets OG5_127111 All targets in OG5_127111
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani mitogen activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Entamoeba histolytica peptidase, C54 family Get druggable targets OG5_127111 All targets in OG5_127111
Brugia malayi MAP kinase sur-1 Get druggable targets OG5_126781 All targets in OG5_126781
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium hominis MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 1 360 aa 361 aa 33.2 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0046 0.0049 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0463 0.1525 1
Echinococcus multilocularis aurora kinase A 0.0068 0.0127 0.0127
Echinococcus multilocularis tyrosine protein kinase shark 0.0046 0.0049 0.0033
Entamoeba histolytica serine/threonine kinase, putative 0.0046 0.0049 0.0084
Brugia malayi Protein kinase domain containing protein 0.0046 0.0049 0.0028
Echinococcus granulosus myotubularin protein 13 0.0043 0.0036 0.0018
Trichomonas vaginalis kinesin light chain, putative 0.0043 0.0036 0.0158
Entamoeba histolytica PH domain containing protein kinase, putative 0.0055 0.0079 0.0289
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0049 0.0017
Trichomonas vaginalis centaurin gamma, putative 0.0043 0.0036 0.0158
Brugia malayi Protein kinase domain containing protein 0.0055 0.0079 0.0058
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0079 0.0442
Loa Loa (eye worm) hypothetical protein 0.0112 0.0283 0.0279
Trypanosoma brucei protein kinase, putative 0.0073 0.0145 1
Brugia malayi follicle stimulating hormone receptor 0.028 0.0875 0.0856
Onchocerca volvulus 0.0043 0.0036 0.0161
Echinococcus granulosus DCC interacting protein 13 beta 0.0043 0.0036 0.0018
Entamoeba histolytica protein kinase domain containing protein 0.0046 0.0049 0.0084
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0046 0.0049 0.0033
Entamoeba histolytica protein kinase domain containing protein 0.0046 0.0049 0.0084
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0079 0.0442
Onchocerca volvulus Putative neuronal RhoA GEF protein 0.0043 0.0036 0.0161
Echinococcus granulosus oxysterol binding protein 3 0.0043 0.0036 0.0018
Loa Loa (eye worm) TK protein kinase 0.0046 0.0049 0.0045
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.061 0.3948
Loa Loa (eye worm) hypothetical protein 0.0111 0.0279 0.0276
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0046 0.0049 0.0033
Echinococcus multilocularis tyrosine kinase 0.0046 0.0049 0.0033
Entamoeba histolytica protein kinase domain containing protein 0.0046 0.0049 0.0084
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0046 0.0049 0.0033
Brugia malayi hypothetical protein 0.0043 0.0036 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0036 0.0158
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0079 0.0442
Schistosoma mansoni axis inhibition protein axin 0.0463 0.1525 0.1499
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.0649 0.4206
Echinococcus multilocularis tyrosine protein kinase HCK 0.0046 0.0049 0.0033
Onchocerca volvulus Phospholipase A2 homolog 0.0111 0.0279 0.1235
Schistosoma mansoni protein kinase 0.0058 0.0092 0.0061
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Loa Loa (eye worm) hypothetical protein 0.0125 0.0329 0.0325
Echinococcus multilocularis collagen type iv alpha 3 binding protein 0.0043 0.0036 0.0018
Brugia malayi Protein kinase domain containing protein 0.0046 0.0049 0.0028
Echinococcus multilocularis FL cytokine receptor 0.0046 0.0049 0.0033
Onchocerca volvulus 0.0365 0.1177 0.521
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0046 0.0049 0.0217
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0046 0.0049 0.0084
Entamoeba histolytica hypothetical protein 0.0046 0.0049 0.0084
Schistosoma mansoni protein kinase 0.0058 0.0092 0.0061
Loa Loa (eye worm) TK protein kinase 0.0046 0.0049 0.0045
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0058 0.0092 0.0085
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0312 0.0989 0.097
Entamoeba histolytica protein kinase, putative 0.0046 0.0049 0.0084
Schistosoma mansoni vesicular amine transporter 0.0115 0.0291 0.0261
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0463 0.1525 1
Brugia malayi Protein kinase domain containing protein 0.0046 0.0049 0.0028
Onchocerca volvulus 0.0671 0.2259 1
Echinococcus multilocularis semaphorin 5B 0.0286 0.0896 0.1049
Echinococcus multilocularis roundabout 2 0.0117 0.0299 0.0333
Entamoeba histolytica protein kinase, putative 0.0046 0.0049 0.0084
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0463 0.1525 0.1499
Toxoplasma gondii aurora kinase 0.0068 0.0127 0.8342
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0034 0.0002
Echinococcus multilocularis G protein coupled receptor kinase 6 0.2396 0.8361 1
Echinococcus granulosus tyrosine protein kinase pr2 0.0046 0.0049 0.0033
Schistosoma mansoni hypothetical protein 0.0046 0.0049 0.0017
Entamoeba histolytica tyrosine kinase, putative 0.0046 0.0049 0.0084
Loa Loa (eye worm) RGC/RGC protein kinase 0.0046 0.0049 0.0045
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Plasmodium falciparum tyrosine kinase-like protein 0.0046 0.0049 0.138
Brugia malayi TAR-binding protein 0.0076 0.0157 0.0135
Entamoeba histolytica tyrosine kinase, putative 0.0046 0.0049 0.0084
Echinococcus multilocularis transfer RNA-Thr 0.0046 0.0049 0.0033
Entamoeba histolytica hypothetical protein 0.0125 0.0329 0.1963
Brugia malayi PH domain containing protein 0.0043 0.0036 0.0015
Loa Loa (eye worm) syntrophin-1 0.0043 0.0036 0.0033
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0043 0.0036 0.0018
Brugia malayi Protein kinase domain containing protein 0.0046 0.0049 0.0028
Entamoeba histolytica hypothetical protein 0.0125 0.0329 0.1963
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0071 0.0138 0.0829
Schistosoma mansoni serine/threonine-protein kinase 0.0055 0.0079 0.0048
Entamoeba histolytica protein kinase, putative 0.0055 0.0079 0.0289
Echinococcus granulosus axis inhibition protein axin 0.0463 0.1525 0.1804
Trichomonas vaginalis alpha chimerin, putative 0.0043 0.0036 0.0158
Trichomonas vaginalis centaurin beta, putative 0.0043 0.0036 0.0158
Echinococcus granulosus tyrosine protein kinase Blk 0.0046 0.0049 0.0033
Brugia malayi hypothetical protein 0.0463 0.1525 0.1507
Trichomonas vaginalis centaurin/arf, putative 0.0043 0.0036 0.0158
Brugia malayi Plekhf2 protein 0.0043 0.0036 0.0015
Schistosoma mansoni phosphoinositol 4-phosphate adaptor protein 0.0043 0.0036 0.0005
Loa Loa (eye worm) TK/Met protein kinase 0.0046 0.0049 0.0045
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Echinococcus multilocularis hypothetical protein 0.0286 0.0896 0.1049
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0055 0.0079 0.3949
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0049 0.0241
Echinococcus granulosus tyrosine protein kinase shark 0.0046 0.0049 0.0033
Leishmania major protein kinase, putative 0.0046 0.0049 0.1151
Brugia malayi Protein kinase domain containing protein 0.0046 0.0049 0.0028
Schistosoma mansoni tyrosine kinase 0.0046 0.0049 0.0017
Toxoplasma gondii STE kinase 0.0046 0.0049 0.1151
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0112 0.0283 0.0313
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Entamoeba histolytica hypothetical protein 0.0046 0.0049 0.0084
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0068 0.0127 0.0611
Echinococcus granulosus Rho GTPase activating protein 24 0.0043 0.0036 0.0018
Loa Loa (eye worm) cytohesin 3 0.0043 0.0036 0.0033
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0046 0.0049 0.0033
Entamoeba histolytica ankyrin repeat protein 0.0046 0.0049 0.0084
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0046 0.0049 0.0033
Echinococcus granulosus aurora kinase A 0.0068 0.0127 0.0127
Brugia malayi Furin-like cysteine rich region family protein 0.0046 0.0049 0.0028
Loa Loa (eye worm) TK/FER protein kinase 0.0046 0.0049 0.0045
Plasmodium falciparum protein kinase, putative 0.0058 0.0092 0.6113
Echinococcus granulosus insulin receptor 0.0046 0.0049 0.0033
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0046 0.0049 0.0084
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0058 0.0092 0.5131
Trichomonas vaginalis development and differentiation-enhancing factor, ddef, putative 0.0043 0.0036 0.0158
Loa Loa (eye worm) hypothetical protein 0.0046 0.0049 0.0045
Entamoeba histolytica protein kinase, putative 0.0046 0.0049 0.0084
Entamoeba histolytica protein kinase, putative 0.0046 0.0049 0.0084
Loa Loa (eye worm) oxysterol binding protein 0.0043 0.0036 0.0033
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Entamoeba histolytica PH domain containing protein kinase, putative 0.0055 0.0079 0.0289
Entamoeba histolytica protein kinase, putative 0.0046 0.0049 0.0084
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.2396 0.8361 0.836
Echinococcus multilocularis Rho GTPase activating protein 24 0.0043 0.0036 0.0018
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0079 0.0442
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0046 0.0049 0.0033
Trichomonas vaginalis TK family protein kinase 0.0046 0.0049 0.0241
Entamoeba histolytica protein kinase domain containing protein 0.0058 0.0092 0.0373
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0046 0.0049 0.0017
Schistosoma mansoni tyrosine kinase 0.0046 0.0049 0.0017
Echinococcus multilocularis protein kinase 0.0046 0.0049 0.0033
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0049 0.0017
Loa Loa (eye worm) sema domain-containing protein 0.0286 0.0896 0.0893
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0036 0.0158
Schistosoma mansoni regulator of G protein signaling 0.0463 0.1525 0.1499
Loa Loa (eye worm) hypothetical protein 0.0463 0.1525 0.1522
Brugia malayi Guanylyl cyclase protein 23 0.0046 0.0049 0.0028
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0046 0.0049 0.0033
Loa Loa (eye worm) hypothetical protein 0.0046 0.0049 0.0045
Schistosoma mansoni protein kinase 0.0046 0.0049 0.0017
Entamoeba histolytica protein kinase, putative 0.0046 0.0049 0.0084
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0046 0.0049 0.0033
Entamoeba histolytica hypothetical protein 0.0463 0.1525 1
Loa Loa (eye worm) hypothetical protein 0.0125 0.0329 0.0325
Schistosoma mansoni oxysterol-binding protein 1 0.0043 0.0036 0.0005
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0081 0.0072
Loa Loa (eye worm) hypothetical protein 0.0046 0.0049 0.0045
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0046 0.0049 0.0033
Brugia malayi Protein kinase domain containing protein 0.0046 0.0049 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0036 0.0158
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Echinococcus granulosus cytohesin 1 0.0043 0.0036 0.0018
Schistosoma mansoni z-protein (S1r protein) 0.0463 0.1525 0.1499
Schistosoma mansoni protein kinase 0.0046 0.0049 0.0017
Entamoeba histolytica tyrosine kinase, putative 0.0046 0.0049 0.0084
Echinococcus multilocularis regulator of G protein signaling 3 0.0463 0.1525 0.1804
Brugia malayi GTPase-activator protein for Ras-like GTPase containing protein 0.0043 0.0036 0.0015
Entamoeba histolytica receptor protein kinase, putative 0.0046 0.0049 0.0084
Echinococcus granulosus dynamin 1 0.0043 0.0036 0.0018
Trypanosoma brucei Pseudokinase, putative 0.0046 0.0049 0.1158
Trichomonas vaginalis AGC family protein kinase 0.0068 0.0127 0.0759
Loa Loa (eye worm) follicle stimulating hormone receptor 0.028 0.0875 0.0872
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0046 0.0049 0.0033
Echinococcus multilocularis regulator of G protein signaling 7 0.0463 0.1525 0.1804
Schistosoma mansoni serine/threonine-protein kinase 0.0055 0.0079 0.0048
Trichomonas vaginalis CMGC family protein kinase 0.0073 0.0145 0.0874
Echinococcus multilocularis pleckstrin y domain containing family A 0.0043 0.0036 0.0018
Echinococcus multilocularis Ras associated and pleckstrin y 0.0043 0.0036 0.0018
Onchocerca volvulus Tyrosine kinase homolog 0.0046 0.0049 0.0217
Echinococcus multilocularis epidermal growth factor receptor 0.0046 0.0049 0.0033
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0079 0.0442
Brugia malayi hypothetical protein 0.0046 0.0049 0.0028
Schistosoma mansoni protein kinase 0.0046 0.0049 0.0017
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0046 0.0049 0.0017
Onchocerca volvulus 0.0043 0.0036 0.0161
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0034 0.0002
Loa Loa (eye worm) hypothetical protein 0.0112 0.0283 0.0279
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0032 0.001
Schistosoma mansoni hypothetical protein 0.0125 0.0329 0.0298
Brugia malayi bone morphogenetic protein type 1 receptor 0.0046 0.0049 0.0028
Trichomonas vaginalis protein kinase atn1, putative 0.0046 0.0049 0.0241
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.0329 0.2089
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0068 0.0127 0.0127
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0036 0.0158
Entamoeba histolytica protein kinase, putative 0.0068 0.0127 0.0611
Echinococcus granulosus natriuretic peptide receptor 1 0.0046 0.0049 0.0033
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.061 0.3948
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0046 0.0049 0.0033
Loa Loa (eye worm) TK/FER protein kinase 0.0046 0.0049 0.0045
Brugia malayi Protein kinase domain containing protein 0.0046 0.0049 0.0028
Loa Loa (eye worm) TK protein kinase 0.0046 0.0049 0.0045
Entamoeba histolytica ankyrin repeat protein 0.0046 0.0049 0.0084
Entamoeba histolytica serine/threonine kinase, putative 0.0046 0.0049 0.0084
Echinococcus granulosus tyrosine kinase 0.0046 0.0049 0.0033
Brugia malayi Protein kinase domain containing protein 0.0046 0.0049 0.0028
Echinococcus granulosus semaphorin 1A 0.0286 0.0896 0.1049
Onchocerca volvulus Abnormal cell migration protein 10 homolog 0.0043 0.0036 0.0161
Schistosoma mansoni tyrosine kinase 0.0046 0.0049 0.0017
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0071 0.0138 0.0829
Brugia malayi Protein kinase domain containing protein 0.0046 0.0049 0.0028
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0079 0.0442
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.061 0.3948
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Echinococcus multilocularis plexin a4 0.0796 0.2702 0.3215
Loa Loa (eye worm) serine/threonine protein kinase 0.0046 0.0049 0.0045
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0049 0.0017
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Loa Loa (eye worm) hypothetical protein 0.0043 0.0036 0.0033
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0463 0.1525 0.1804
Loa Loa (eye worm) TK/EPH protein kinase 0.0046 0.0049 0.0045
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0046 0.0049 0.0033
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Loa Loa (eye worm) hypothetical protein 0.0043 0.0036 0.0033
Brugia malayi Tyrosine-protein kinase PR2 0.0046 0.0049 0.0028
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0079 0.0442
Entamoeba histolytica protein kinase domain containing protein 0.0046 0.0049 0.0084
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0046 0.0049 0.0241
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0036 0.0158
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0073 0.0145 1
Echinococcus granulosus tar DNA binding protein 0.0076 0.0157 0.0162
Echinococcus multilocularis G protein coupled receptor kinase 1 0.1728 0.6 0.7169
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0989 0.6456
Loa Loa (eye worm) TK/EGFR protein kinase 0.0046 0.0049 0.0045
Echinococcus granulosus regulator of G protein signaling 7 0.0463 0.1525 0.1804
Echinococcus multilocularis Arf GAP and Pleckstrin domain containing protein 0.0043 0.0036 0.0018
Echinococcus multilocularis tyrosine protein kinase Abl 0.0046 0.0049 0.0033
Brugia malayi hypothetical protein 0.0046 0.0049 0.0028
Trypanosoma brucei rac serine-threonine kinase, putative 0.0055 0.0079 0.3973
Echinococcus granulosus tyrosine protein kinase 0.0046 0.0049 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0463 0.1525 1
Brugia malayi Sema domain containing protein 0.0286 0.0896 0.0877
Brugia malayi Oxysterol-binding protein 0.0043 0.0036 0.0015
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0157 0.0153
Entamoeba histolytica protein kinase domain containing protein 0.0046 0.0049 0.0084
Schistosoma mansoni protein kinase 0.0046 0.0049 0.0017
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Echinococcus multilocularis regulator of G protein signaling 7 0.0463 0.1525 0.1804
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0145 1
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Brugia malayi PH domain containing protein 0.0043 0.0036 0.0015
Brugia malayi Plexin repeat family protein 0.0671 0.2259 0.2243
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0158 0.0445 0.0442
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Entamoeba histolytica PH domain containing protein kinase, putative 0.0055 0.0079 0.0289
Schistosoma mansoni protein kinase 0.0046 0.0049 0.0017
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0073 0.0145 0.0141
Echinococcus multilocularis beta adrenergic receptor kinase 0.2192 0.7639 0.9135
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0046 0.0049 0.0017
Echinococcus multilocularis tyrosine protein kinase csk 0.0046 0.0049 0.0033
Loa Loa (eye worm) TK/FER protein kinase 0.0046 0.0049 0.0045
Echinococcus multilocularis natriuretic peptide receptor 1 0.0046 0.0049 0.0033
Brugia malayi hypothetical protein 0.0286 0.0896 0.0877
Onchocerca volvulus outspread protein homolog 0.0043 0.0036 0.0161
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0092 0.0071
Trichomonas vaginalis protein tyrosine kinase, putative 0.0046 0.0049 0.0241
Schistosoma mansoni tyrosine kinase 0.0046 0.0049 0.0017
Schistosoma mansoni tyrosine kinase 0.0046 0.0049 0.0017
Echinococcus granulosus transcription factor collier 0.0125 0.0329 0.0368
Trichomonas vaginalis conserved hypothetical protein 0.0463 0.1525 1
Entamoeba histolytica protein kinase, putative 0.0046 0.0049 0.0084
Echinococcus multilocularis Pleckstrin y 0.0043 0.0036 0.0018
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Loa Loa (eye worm) hypothetical protein 0.0043 0.0036 0.0033
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0043 0.0036 0.0033
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0046 0.0049 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0036 0.0158
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Entamoeba histolytica serine/threonine kinase, putative 0.0046 0.0049 0.0084
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0046 0.0049 0.0084
Echinococcus granulosus retinal guanylyl cyclase 2 0.0046 0.0049 0.0033
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0071 0.0138 0.0829
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0055 0.0079 0.3973
Echinococcus granulosus Immunoglobulin 0.0112 0.0283 0.0313
Loa Loa (eye worm) TK protein kinase 0.0046 0.0049 0.0045
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0125 0.0329 0.2089
Brugia malayi Dynamin 0.0043 0.0036 0.0015
Schistosoma mansoni survival motor neuron protein 0.0058 0.0092 0.0061
Entamoeba histolytica serine/threonine kinase, putative 0.0046 0.0049 0.0084
Entamoeba histolytica protein kinase domain containing protein 0.0046 0.0049 0.0084
Onchocerca volvulus 0.0043 0.0036 0.0161
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0058 0.0092 0.5131
Schistosoma mansoni protein tyrosine kinase 0.0046 0.0049 0.0017
Echinococcus multilocularis DCC interacting protein 13 beta 0.0043 0.0036 0.0018
Echinococcus granulosus GRB2 associated binding protein 3 0.0043 0.0036 0.0018
Brugia malayi Protein kinase domain containing protein 0.0046 0.0049 0.0028
Loa Loa (eye worm) hypothetical protein 0.0043 0.0036 0.0033
Entamoeba histolytica serine/threonine kinase, putative 0.0046 0.0049 0.0084
Brugia malayi Variant SH3 domain containing protein 0.0043 0.0036 0.0015
Echinococcus granulosus receptor type guanylyl cyclase 0.0046 0.0049 0.0033
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0079 0.0442
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0055 0.0079 0.4733
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0068 0.0127 0.0611
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0145 0.5
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Entamoeba histolytica protein kinase, putative 0.0055 0.0079 0.0289
Echinococcus granulosus tyrosine protein kinase ABL1 0.0046 0.0049 0.0033
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0046 0.0049 0.0033
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0081 0.005
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0046 0.0049 0.0033
Brugia malayi Protein kinase domain containing protein 0.0046 0.0049 0.0028
Loa Loa (eye worm) AUR protein kinase 0.0068 0.0127 0.0124
Loa Loa (eye worm) hypothetical protein 0.0286 0.0896 0.0893
Entamoeba histolytica hypothetical protein 0.0046 0.0049 0.0084
Schistosoma mansoni serine/threonine RGC 0.0046 0.0049 0.0017
Brugia malayi serine/threonine-protein kinase 6 0.0068 0.0127 0.0106
Echinococcus granulosus calcium dependent secretion activator 1 0.0043 0.0036 0.0018
Loa Loa (eye worm) TK/FER protein kinase 0.0046 0.0049 0.0045
Entamoeba histolytica protein kinase, putative 0.0046 0.0049 0.0084
Loa Loa (eye worm) hypothetical protein 0.0043 0.0036 0.0033
Echinococcus multilocularis arf GAP with coiled coil, ANK repeat and PH 0.0043 0.0036 0.0018
Echinococcus granulosus raf serine:threonine protein kinase 0.0046 0.0049 0.0033
Onchocerca volvulus 0.0043 0.0036 0.0161
Echinococcus granulosus regulator of G protein signaling 7 0.0463 0.1525 0.1804
Brugia malayi hypothetical protein 0.0463 0.1525 0.1507
Brugia malayi hypothetical protein 0.0286 0.0896 0.0877
Brugia malayi protein-tyrosine kinase 0.0046 0.0049 0.0028
Echinococcus multilocularis oxysterol binding protein 3 0.0043 0.0036 0.0018
Schistosoma mansoni tyrosine kinase 0.0046 0.0049 0.0017
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0046 0.0049 0.0084
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0068 0.0127 0.0611
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0081 0.005
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0463 0.1525 0.1522
Entamoeba histolytica protein kinase domain containing protein 0.0046 0.0049 0.0084
Echinococcus granulosus retinal guanylyl cyclase 2 0.0046 0.0049 0.0033
Trichomonas vaginalis centaurin alpha, putative 0.0043 0.0036 0.0158
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0046 0.0049 0.0033
Echinococcus granulosus serine/threonine protein kinase 0.0055 0.0079 0.007
Echinococcus granulosus fibroblast growth factor receptor 4 0.0046 0.0049 0.0033
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0079 0.0442
Schistosoma mansoni tyrosine kinase 0.0046 0.0049 0.0017
Brugia malayi Immunoglobulin I-set domain containing protein 0.0158 0.0445 0.0425
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0079 0.0442
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Loa Loa (eye worm) RNA binding protein 0.0076 0.0157 0.0153
Brugia malayi Cytohesin 3 0.0043 0.0036 0.0015
Plasmodium falciparum calcium-dependent protein kinase 7 0.0055 0.0079 0.4733
Brugia malayi A-kinase anchor protein 10, precursor 0.0463 0.1525 0.1507
Entamoeba histolytica tyrosine kinase, putative 0.0046 0.0049 0.0084
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Loa Loa (eye worm) TK/ABL protein kinase 0.0046 0.0049 0.0045
Echinococcus multilocularis oxysterol binding protein 1 0.0043 0.0036 0.0018
Brugia malayi serine/threonine protein kinase 6 0.0068 0.0127 0.0106
Onchocerca volvulus 0.0046 0.0049 0.0217
Echinococcus granulosus G protein coupled receptor kinase 1 0.1728 0.6 0.7169
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0073 0.0145 1
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0058 0.0092 0.0085
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0046 0.0049 0.0028
Echinococcus multilocularis raf serine:threonine protein kinase 0.0046 0.0049 0.0033
Schistosoma mansoni tyrosine kinase 0.0046 0.0049 0.0017
Loa Loa (eye worm) hypothetical protein 0.0117 0.0299 0.0296
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Echinococcus multilocularis activin receptor type 0.0058 0.0092 0.0085
Onchocerca volvulus 0.0043 0.0036 0.0161
Echinococcus multilocularis transcription factor collier 0.0125 0.0329 0.0368
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0071 0.0138 0.9316
Echinococcus multilocularis type II inositol 3,4 bisphosphate 4 phosphatase 0.0043 0.0036 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0049 0.0241
Brugia malayi Phospholipase A2 family protein 0.0111 0.0279 0.0258
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0081 0.0072
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Entamoeba histolytica tyrosin kinase, putative 0.0046 0.0049 0.0084
Brugia malayi SRC-1 0.0046 0.0049 0.0028
Echinococcus granulosus expressed protein 0.0463 0.1525 0.1804
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Schistosoma mansoni serine/threonine protein kinase 0.0068 0.0127 0.0096
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0036 0.0158
Loa Loa (eye worm) AUR protein kinase 0.0068 0.0127 0.0124
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0079 0.0442
Echinococcus granulosus pleckstrin y domain containing family A 0.0043 0.0036 0.0018
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0071 0.0138 0.0107
Loa Loa (eye worm) TK/DDR protein kinase 0.0046 0.0049 0.0045
Echinococcus granulosus epidermal growth factor receptor 0.0046 0.0049 0.0033
Loa Loa (eye worm) hypothetical protein 0.0043 0.0036 0.0033
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0046 0.0049 0.0084
Echinococcus multilocularis heat shock protein 70 0.0046 0.0049 0.0033
Entamoeba histolytica hypothetical protein 0.0046 0.0049 0.0084
Loa Loa (eye worm) hypothetical protein 0.0286 0.0896 0.0893
Schistosoma mansoni goodpasture antigen-binding protein 0.0043 0.0036 0.0005
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0046 0.0049 0.0033
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0055 0.0079 0.3973
Leishmania major folate/biopterin transporter, putative 0.0055 0.0079 0.3949
Brugia malayi Protein kinase domain containing protein 0.0046 0.0049 0.0028
Echinococcus multilocularis actin binding protein anillin 0.0043 0.0036 0.0018
Entamoeba histolytica hypothetical protein 0.0046 0.0049 0.0084
Echinococcus multilocularis Pleckstrin y 0.0043 0.0036 0.0018
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0081 0.006
Trypanosoma brucei Flagellum attachment zone protein 20 0.0046 0.0049 0.1158
Echinococcus multilocularis insulin receptor 0.0046 0.0049 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0049 0.0241
Loa Loa (eye worm) hypothetical protein 0.0043 0.0036 0.0033
Schistosoma mansoni regulator of G protein signaling 0.0463 0.1525 0.1499
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0046 0.0049 0.0084
Echinococcus granulosus tyrosine protein kinase Fyn 0.0046 0.0049 0.0033
Echinococcus granulosus Pleckstrin y 0.0043 0.0036 0.0018
Echinococcus granulosus pdz domain containing protein 0.0043 0.0036 0.0018
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.0046 0.0049 0.0084
Echinococcus multilocularis calcium dependent secretion activator 1 0.0043 0.0036 0.0018
Entamoeba histolytica hypothetical protein 0.0055 0.0079 0.0289
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0046 0.0049 0.0217
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0046 0.0049 0.0084
Brugia malayi Protein kinase domain containing protein 0.0046 0.0049 0.0028
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0043 0.0036 0.0033
Schistosoma mansoni tyrosine kinase 0.0046 0.0049 0.0017
Echinococcus multilocularis tyrosine protein kinase Blk 0.0046 0.0049 0.0033
Leishmania major protein kinase, putative 0.0068 0.0127 0.8342
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0046 0.0049 0.0033
Entamoeba histolytica tyrosine kinase, putative 0.0046 0.0049 0.0084
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0073 0.0145 0.994
Loa Loa (eye worm) TK/FER protein kinase 0.0046 0.0049 0.0045
Echinococcus granulosus neuroglian 0.0112 0.0283 0.0313
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0463 0.1525 0.1499
Entamoeba histolytica protein kinase domain containing protein 0.0046 0.0049 0.0084
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Schistosoma mansoni hypothetical protein 0.0286 0.0896 0.0867
Loa Loa (eye worm) TK/FER protein kinase 0.0046 0.0049 0.0045
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.0649 0.4206
Brugia malayi Protein kinase domain containing protein 0.0046 0.0049 0.0028
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0046 0.0049 0.0017
Loa Loa (eye worm) hypothetical protein 0.0043 0.0036 0.0033
Schistosoma mansoni hypothetical protein 0.0043 0.0036 0.0005
Echinococcus granulosus protein tyrosine kinase 0.0046 0.0049 0.0033
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0157 0.0162
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0055 0.0079 0.3973
Toxoplasma gondii protein kinase domain-containing protein 0.0046 0.0049 0.1151
Loa Loa (eye worm) hypothetical protein 0.0043 0.0036 0.0033
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0043 0.0036 0.0015
Loa Loa (eye worm) TK protein kinase 0.0046 0.0049 0.0045
Loa Loa (eye worm) TK/RYK protein kinase 0.0046 0.0049 0.0045
Entamoeba histolytica hypothetical protein, conserved 0.0046 0.0049 0.0084
Loa Loa (eye worm) hypothetical protein 0.0671 0.2259 0.2257
Echinococcus granulosus integrin linked protein kinase 0.0046 0.0049 0.0033
Echinococcus granulosus geminin 0.0205 0.061 0.0706
Entamoeba histolytica protein kinase domain containing protein 0.0046 0.0049 0.0084
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0046 0.0049 0.0045
Echinococcus granulosus type II inositol 34 bisphosphate 4 phosphatase 0.0043 0.0036 0.0018
Schistosoma mansoni hypothetical protein 0.0125 0.0329 0.0298
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0046 0.0049 0.0033
Plasmodium vivax tyrosine kinase-like protein, putative 0.0046 0.0049 0.138
Entamoeba histolytica protein kinase, putative 0.0046 0.0049 0.0084
Loa Loa (eye worm) hypothetical protein 0.0043 0.0036 0.0033
Echinococcus multilocularis protein kinase 0.0046 0.0049 0.0033
Trypanosoma cruzi NIMA-related kinase, putative 0.0055 0.0079 0.3973
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.2396 0.8361 1
Trichomonas vaginalis AGC family protein kinase 0.0068 0.0127 0.0759
Schistosoma mansoni tyrosine kinase 0.0046 0.0049 0.0017
Entamoeba histolytica tyrosine kinase, putative 0.0046 0.0049 0.0084
Trichomonas vaginalis protein transport protein sec7, putative 0.0043 0.0036 0.0158
Echinococcus multilocularis exocyst complex component 2 0.0125 0.0329 0.0368
Trypanosoma cruzi protein kinase, putative 0.0046 0.0049 0.1158
Entamoeba histolytica protein kinase, putative 0.0046 0.0049 0.0084
Trichomonas vaginalis CMGC family protein kinase 0.0073 0.0145 0.0874
Echinococcus granulosus kinase suppressor of Ras 1 0.0046 0.0049 0.0033
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Echinococcus multilocularis myotubularin protein 13 0.0043 0.0036 0.0018
Loa Loa (eye worm) hypothetical protein 0.0043 0.0036 0.0033
Brugia malayi Dynamin 0.0043 0.0036 0.0015
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0055 0.0079 0.3973
Echinococcus granulosus tyrosine protein kinase csk 0.0046 0.0049 0.0033
Brugia malayi serine/threonine kinase 12 0.0068 0.0127 0.0106
Echinococcus multilocularis Pleckstrin y 0.0043 0.0036 0.0018
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0046 0.0049 0.0017
Brugia malayi Peptidase family C54 containing protein 0.0071 0.0138 0.0117
Entamoeba histolytica protein kinase domain containing protein 0.0046 0.0049 0.0084
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0157 0.0125
Brugia malayi Protein kinase domain containing protein 0.0046 0.0049 0.0028
Entamoeba histolytica protein kinase , putative 0.0068 0.0127 0.0611
Schistosoma mansoni goodpasture antigen-binding protein 0.0043 0.0036 0.0005
Loa Loa (eye worm) hypothetical protein 0.0286 0.0896 0.0893
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0046 0.0049 0.0045
Loa Loa (eye worm) hypothetical protein 0.0286 0.0896 0.0893
Onchocerca volvulus 0.0043 0.0036 0.0161
Brugia malayi probable spectrin beta chain 0.0043 0.0036 0.0015
Onchocerca volvulus 0.0046 0.0049 0.0217
Entamoeba histolytica protein kinase, putative 0.0068 0.0127 0.0611
Loa Loa (eye worm) hypothetical protein 0.0528 0.1753 0.175
Loa Loa (eye worm) hypothetical protein 0.0046 0.0049 0.0045
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Brugia malayi Fibronectin type III domain containing protein 0.0117 0.0299 0.0278
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0055 0.0079 0.0442
Entamoeba histolytica protein kinase, putative 0.0046 0.0049 0.0084
Onchocerca volvulus 0.0058 0.0092 0.0408
Entamoeba histolytica cysteine surface protein, putative 0.0046 0.0049 0.0084
Schistosoma mansoni serine/threonine protein kinase 0.2192 0.7639 0.7632
Leishmania major protein kinase, putative 0.0055 0.0079 0.3949
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Echinococcus granulosus exocyst complex component 2 0.0125 0.0329 0.0368
Brugia malayi Protein kinase domain containing protein 0.0046 0.0049 0.0028
Entamoeba histolytica protein kinase, putative 0.0055 0.0079 0.0289
Echinococcus granulosus regulator of G protein signaling 3 0.0463 0.1525 0.1804
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0046 0.0049 0.0033
Brugia malayi Syntrophin-1 0.0043 0.0036 0.0015
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0046 0.0049 0.0084
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0145 0.5
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0079 0.0442
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.0043 0.0036 0.0018
Entamoeba histolytica hypothetical protein 0.0046 0.0049 0.0084
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0036 0.0158
Loa Loa (eye worm) TK/CSK protein kinase 0.0046 0.0049 0.0045
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0145 0.0149
Echinococcus granulosus cysteine protease atg4b 0.0071 0.0138 0.014
Entamoeba histolytica p21-activated kinase 0.0055 0.0079 0.0289
Leishmania major serine/threonine-protein kinase a, putative 0.0055 0.0079 0.3949
Echinococcus granulosus defective proboscis extension response 0.0112 0.0283 0.0313
Loa Loa (eye worm) hypothetical protein 0.0125 0.0329 0.0325
Schistosoma mansoni cell adhesion molecule 0.0117 0.0299 0.0269
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.0046 0.0049 0.0084
Leishmania major protein kinase, putative 0.0058 0.0092 0.51
Leishmania major protein kinase, putative 0.0055 0.0079 0.3949
Onchocerca volvulus 0.0046 0.0049 0.0217
Schistosoma mansoni tyrosine protein kinase 0.0046 0.0049 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0049 0.0241
Echinococcus multilocularis tyrosine protein kinase 0.0046 0.0049 0.0033
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Echinococcus granulosus tyrosine protein kinase Fyn 0.0046 0.0049 0.0033
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0073 0.0145 0.994
Schistosoma mansoni serine/threonine protein kinase 0.2192 0.7639 0.7632
Loa Loa (eye worm) TK/FAK protein kinase 0.0046 0.0049 0.0045
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.061 0.3948
Brugia malayi IPT/TIG domain containing protein 0.0125 0.0329 0.0308
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0079 0.0442
Loa Loa (eye worm) hypothetical protein 0.0463 0.1525 0.1522
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.0896 0.1049
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0068 0.0127 0.0127
Loa Loa (eye worm) RGC/RGC protein kinase 0.0046 0.0049 0.0045
Entamoeba histolytica hypothetical protein 0.0046 0.0049 0.0084
Entamoeba histolytica protein kinase, putative 0.0046 0.0049 0.0084
Brugia malayi Receptor family ligand binding region containing protein 0.0046 0.0049 0.0028
Loa Loa (eye worm) TK/FER protein kinase 0.0046 0.0049 0.0045
Entamoeba histolytica tyrosine kinase, putative 0.0046 0.0049 0.0084
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0079 0.0442
Loa Loa (eye worm) TK/FER protein kinase 0.0046 0.0049 0.0045
Echinococcus multilocularis tyrosine protein kinase csk 0.0046 0.0049 0.0033
Loa Loa (eye worm) hypothetical protein 0.0463 0.1525 0.1522
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Loa Loa (eye worm) hypothetical protein 0.0046 0.0049 0.0045
Brugia malayi regulator of G-protein signaling rgs-7 0.0463 0.1525 0.1507
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0989 0.6456
Loa Loa (eye worm) hypothetical protein 0.0043 0.0036 0.0033
Brugia malayi Protein kinase domain containing protein 0.0046 0.0049 0.0028
Entamoeba histolytica hypothetical protein 0.0046 0.0049 0.0084
Brugia malayi PH domain containing protein 0.0043 0.0036 0.0015
Brugia malayi integrin-linked kinase 0.0046 0.0049 0.0028
Trypanosoma brucei AUT2/APG4/ATG4 cysteine peptidase, putative 0.0071 0.0138 0.9372
Entamoeba histolytica hypothetical protein 0.0463 0.1525 1
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0046 0.0049 0.0045
Entamoeba histolytica protein kinase, putative 0.0046 0.0049 0.0084
Entamoeba histolytica tyrosine kinase, putative 0.0046 0.0049 0.0084
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Schistosoma mansoni guanyl-nucleotide exchange factor 0.0043 0.0036 0.0005
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0125 0.0329 0.2089
Loa Loa (eye worm) TK/FER protein kinase 0.0046 0.0049 0.0045
Onchocerca volvulus 0.0046 0.0049 0.0217
Loa Loa (eye worm) SRC-1 0.0046 0.0049 0.0045
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Trichomonas vaginalis CMGC family protein kinase 0.0073 0.0145 0.0874
Echinococcus granulosus oxysterol binding protein 9 0.0043 0.0036 0.0018
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0079 0.0442
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0046 0.0049 0.0033
Brugia malayi Regulator of G protein signaling domain containing protein 0.0463 0.1525 0.1507
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Brugia malayi Protein kinase domain containing protein 0.0046 0.0049 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0036 0.0158
Brugia malayi Protein kinase domain containing protein 0.0046 0.0049 0.0028
Trypanosoma cruzi aurora B kinase, putative 0.0068 0.0127 0.8393
Schistosoma mansoni axis inhibition protein axin 0.0463 0.1525 0.1499
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0046 0.0049 0.0033
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0046 0.0049 0.0017
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0049 0.0241
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0125 0.0329 0.2089
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0071 0.0138 0.0107
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0046 0.0049 0.0028
Schistosoma mansoni protein kinase 0.0046 0.0049 0.0017
Brugia malayi SH2 domain containing protein 0.0046 0.0049 0.0028
Echinococcus granulosus tyrosine protein kinase Lyn 0.0058 0.0092 0.0085
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0038 0.0022 0.0018
Echinococcus granulosus activin receptor type 0.0058 0.0092 0.0085
Loa Loa (eye worm) TK/FER protein kinase 0.0046 0.0049 0.0045
Schistosoma mansoni autophagin-1 (C54 family) 0.0071 0.0138 0.0107
Onchocerca volvulus Glucosylceramidase homolog 0.0205 0.061 0.2699
Echinococcus granulosus Arf GAP and Pleckstrin domain containing protein 0.0043 0.0036 0.0018
Brugia malayi hypothetical protein 0.0046 0.0049 0.0028
Brugia malayi PXA domain containing protein 0.0463 0.1525 0.1507
Brugia malayi MAX-1A 0.0043 0.0036 0.0015
Loa Loa (eye worm) TK/ALK protein kinase 0.0275 0.086 0.0857
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0157 0.0153
Loa Loa (eye worm) plexin A 0.0796 0.2702 0.2699
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0049 0.0241
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0081 0.0072
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0157 0.0135
Onchocerca volvulus 0.0046 0.0049 0.0217
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0046 0.0049 0.0033
Loa Loa (eye worm) hypothetical protein 0.0365 0.1177 0.1174
Loa Loa (eye worm) TK/FER protein kinase 0.0046 0.0049 0.0045
Echinococcus multilocularis beta 1 syntrophin 0.0043 0.0036 0.0018
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0055 0.0079 0.0442
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0046 0.0049 0.0033
Entamoeba histolytica tyrosine kinase, putative 0.0046 0.0049 0.0084
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0049 0.0241
Onchocerca volvulus 0.0046 0.0049 0.0217
Loa Loa (eye worm) TK/FER protein kinase 0.0046 0.0049 0.0045
Loa Loa (eye worm) hypothetical protein 0.0046 0.0049 0.0045
Entamoeba histolytica tyrosine kinase, putative 0.0046 0.0049 0.0084
Echinococcus multilocularis Pleckstrin domain containing protein, family B 0.0043 0.0036 0.0018
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0079 0.0442
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0099 0.0095
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0079 0.0442
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0079 0.0442
Entamoeba histolytica protein kinase, putative 0.0055 0.0079 0.0289
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0046 0.0049 0.0241
Echinococcus multilocularis Regulator of G protein signaling 20 0.0463 0.1525 0.1804
Brugia malayi plexin A 0.0796 0.2702 0.2686
Echinococcus multilocularis ras specific guanine nucleotide releasing factor 0.0043 0.0036 0.0018
Loa Loa (eye worm) hypothetical protein 0.0043 0.0036 0.0033
Schistosoma mansoni nephrin 0.0117 0.0299 0.0269
Loa Loa (eye worm) hypothetical protein 0.0043 0.0036 0.0033
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0079 0.0442
Schistosoma mansoni hypothetical protein 0.0043 0.0036 0.0005
Echinococcus multilocularis dynamin 1 0.0043 0.0036 0.0018
Schistosoma mansoni hypothetical protein 0.0043 0.0036 0.0005
Schistosoma mansoni rho gtpase activating protein 0.0043 0.0036 0.0005
Trichomonas vaginalis ankyrin repeat and FYVE domain containing protein, putative 0.0043 0.0036 0.0158
Onchocerca volvulus 0.0286 0.0896 0.3967
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0046 0.0049 0.0045
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Trichomonas vaginalis protein transport protein sec7, putative 0.0043 0.0036 0.0158
Schistosoma mansoni protein kinase 0.0046 0.0049 0.0017
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0046 0.0049 0.0045
Brugia malayi Cadps2 protein 0.0043 0.0036 0.0015
Loa Loa (eye worm) hypothetical protein 0.0112 0.0283 0.0279
Schistosoma mansoni tyrosine kinase 0.0046 0.0049 0.0017
Trichomonas vaginalis hypothetical protein 0.0043 0.0036 0.0158
Echinococcus multilocularis neuroglian 0.0112 0.0283 0.0313
Loa Loa (eye worm) hypothetical protein 0.0202 0.06 0.0596
Echinococcus granulosus axis inhibition protein axin 0.0463 0.1525 0.1804
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0055 0.0079 0.3973
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0079 0.0442
Loa Loa (eye worm) sema domain-containing protein 0.0286 0.0896 0.0893
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0051 0.0066 0.0053
Echinococcus multilocularis regulator of G protein signaling 3 0.0463 0.1525 0.1804
Plasmodium falciparum protein kinase, putative 0.0046 0.0049 0.138
Echinococcus multilocularis Immunoglobulin 0.0112 0.0283 0.0313
Schistosoma mansoni hypothetical protein 0.0286 0.0896 0.0867
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0079 0.0442
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0055 0.0079 0.3973
Brugia malayi PH domain containing protein 0.0043 0.0036 0.0015
Schistosoma mansoni tyrosine kinase 0.0046 0.0049 0.0017
Schistosoma mansoni oxysterol-binding protein 1 0.0043 0.0036 0.0005
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0049 0.0017
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0071 0.0138 0.9372
Giardia lamblia Aurora kinase 0.0068 0.0127 0.8182
Loa Loa (eye worm) hypothetical protein 0.0117 0.0299 0.0296
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Echinococcus multilocularis Immunoglobulin 0.0112 0.0283 0.0313
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0079 0.0442
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0046 0.0049 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0036 0.0158
Brugia malayi Variant SH3 domain containing protein 0.0043 0.0036 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0036 0.0158
Brugia malayi Pleckstrin Homology Domain 0.0043 0.0036 0.0015
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0055 0.0079 0.3973
Echinococcus granulosus Pleckstrin domain containing protein family B 0.0043 0.0036 0.0018
Plasmodium vivax tyrosine kinase-like protein, putative 0.0046 0.0049 0.138
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0043 0.0036 0.0005
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0112 0.0283 0.0313
Loa Loa (eye worm) hypothetical protein 0.0043 0.0036 0.0033
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0989 0.6456
Entamoeba histolytica serine/threonine kinase, putative 0.0046 0.0049 0.0084
Entamoeba histolytica hypothetical protein 0.0463 0.1525 1
Brugia malayi PH domain containing protein 0.0043 0.0036 0.0015
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0043 0.0036 0.0158
Echinococcus granulosus oxysterol binding protein 1 0.0043 0.0036 0.0018
Loa Loa (eye worm) Plekhf2 protein 0.0043 0.0036 0.0033
Onchocerca volvulus Protein melted homolog 0.0043 0.0036 0.0161
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0157 0.0125
Schistosoma mansoni protein kinase 0.0068 0.0127 0.0096
Schistosoma mansoni hypothetical protein 0.0043 0.0036 0.0005
Entamoeba histolytica protein kinase, putative 0.0055 0.0079 0.0289
Trichomonas vaginalis AGC family protein kinase 0.0046 0.0049 0.0241
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0073 0.0145 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0032 0.0028
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0046 0.0049 0.0045
Schistosoma mansoni serine/threonine protein kinase 0.0073 0.0145 0.0114
Schistosoma mansoni semaphorin 5-related 0.0286 0.0896 0.0867
Echinococcus multilocularis mitogen activated protein kinase 0.0073 0.0145 0.0148
Loa Loa (eye worm) PH domain-containing protein 0.0043 0.0036 0.0033
Schistosoma mansoni tyrosine kinase 0.0046 0.0049 0.0017
Brugia malayi Oxysterol binding protein 0.0043 0.0036 0.0015
Echinococcus granulosus collagen type iv alpha 3 binding protein 0.0043 0.0036 0.0018
Entamoeba histolytica tyrosine kinase, putative 0.0046 0.0049 0.0084
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0046 0.0049 0.0033
Loa Loa (eye worm) hypothetical protein 0.0117 0.0299 0.0296
Schistosoma mansoni myotubularin-related protein 0.0043 0.0036 0.0005
Brugia malayi Regulator of G protein signaling domain containing protein 0.0463 0.1525 0.1507
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0058 0.0092 0.5131
Echinococcus granulosus ras specific guanine nucleotide releasing factor 0.0043 0.0036 0.0018
Brugia malayi Protein kinase domain containing protein 0.0046 0.0049 0.0028
Loa Loa (eye worm) hypothetical protein 0.0043 0.0036 0.0033
Brugia malayi RNA binding protein 0.0076 0.0157 0.0135
Schistosoma mansoni hypothetical protein 0.0058 0.0092 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0463 0.1525 1
Schistosoma mansoni hypothetical protein 0.0385 0.1249 0.1221
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0046 0.0049 0.0084
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0043 0.0036 0.0158
Onchocerca volvulus 0.0046 0.0049 0.0217
Plasmodium falciparum tyrosine kinase-like protein 0.0046 0.0049 0.138
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0046 0.0049 0.0033
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0046 0.0049 0.1151
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0079 0.0442
Echinococcus multilocularis cytohesin 1 0.0043 0.0036 0.0018
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0051 0.0066 0.0053
Schistosoma mansoni fibrocystin l 0.0125 0.0329 0.0298
Schistosoma mansoni tyrosine kinase 0.0046 0.0049 0.0017
Loa Loa (eye worm) rho-GTPase-activating 0.0043 0.0036 0.0033
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0079 0.0442
Echinococcus multilocularis c src tyrosine kinase 0.0046 0.0049 0.0033
Brugia malayi hypothetical protein 0.0365 0.1177 0.1158
Echinococcus granulosus tyrosine kinase 0.0046 0.0049 0.0033
Echinococcus multilocularis expressed protein 0.0463 0.1525 0.1804
Loa Loa (eye worm) TK protein kinase 0.0046 0.0049 0.0045
Echinococcus multilocularis receptor type guanylyl cyclase 0.0046 0.0049 0.0033
Entamoeba histolytica receptor protein kinase, putative 0.0046 0.0049 0.0084
Loa Loa (eye worm) hypothetical protein 0.0043 0.0036 0.0033
Echinococcus granulosus roundabout 2 0.0117 0.0299 0.0333
Loa Loa (eye worm) TK protein kinase 0.0046 0.0049 0.0045
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0046 0.0049 0.0045
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0046 0.0049 0.0033
Loa Loa (eye worm) TK protein kinase 0.0046 0.0049 0.0045
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0157 0.0125
Loa Loa (eye worm) hypothetical protein 0.0125 0.0329 0.0325
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0312 0.0989 0.0986
Trichomonas vaginalis conserved hypothetical protein 0.0463 0.1525 1
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0463 0.1525 0.1804
Loa Loa (eye worm) hypothetical protein 0.0385 0.1249 0.1246
Loa Loa (eye worm) RhoGEF domain-containing protein 0.0043 0.0036 0.0033
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0081 0.0078
Brugia malayi Protein kinase domain containing protein 0.0046 0.0049 0.0028
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.2192 0.7639 0.7638
Schistosoma mansoni tyrosine kinase 0.0046 0.0049 0.0017
Plasmodium falciparum serine/threonine protein kinase, putative 0.0068 0.0127 1
Schistosoma mansoni hypothetical protein 0.0043 0.0036 0.0005
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0463 0.1525 0.1499
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0046 0.0049 0.0033
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0157 0.0125
Loa Loa (eye worm) hypothetical protein 0.0463 0.1525 0.1522
Schistosoma mansoni protein kinase 0.0046 0.0049 0.0017
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0125 0.0329 0.2089
Onchocerca volvulus 0.0046 0.0049 0.0217
Echinococcus multilocularis tyrosine protein kinase Srms 0.0046 0.0049 0.0033
Entamoeba histolytica hypothetical protein 0.0046 0.0049 0.0084
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.061 0.3948
Schistosoma mansoni tyrosine kinase 0.0046 0.0049 0.0017
Entamoeba histolytica protein kinase domain containing protein 0.0046 0.0049 0.0084
Trichomonas vaginalis CMGC family protein kinase 0.0073 0.0145 0.0874
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0099 0.0078
Entamoeba histolytica protein kinase domain containing protein 0.0046 0.0049 0.0084
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0055 0.0079 0.3973
Loa Loa (eye worm) RGS-3 protein 0.0463 0.1525 0.1522
Schistosoma mansoni plexin 0.0385 0.1249 0.1221
Loa Loa (eye worm) hypothetical protein 0.0043 0.0036 0.0033
Entamoeba histolytica hypothetical protein 0.0046 0.0049 0.0084
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0046 0.0049 0.0241
Onchocerca volvulus Putative zinc finger protein 0.0043 0.0036 0.0161
Schistosoma mansoni tyrosine kinase 0.0046 0.0049 0.0017
Echinococcus granulosus Pleckstrin y 0.0043 0.0036 0.0018
Echinococcus granulosus semaphorin 5B 0.0286 0.0896 0.1049
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0036 0.0158
Brugia malayi C-terminal src kinase protein 1 0.0046 0.0049 0.0028
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0046 0.0049 0.0028
Onchocerca volvulus 0.0046 0.0049 0.0217
Echinococcus granulosus arf GAP with coiled coil ANK repeat and PH 0.0043 0.0036 0.0018
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0055 0.0079 0.3973
Echinococcus granulosus tyrosine protein kinase HCK 0.0046 0.0049 0.0033
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0046 0.0049 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.0329 0.2089
Echinococcus granulosus beta 1 syntrophin 0.0043 0.0036 0.0018
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0046 0.0049 0.0084
Echinococcus granulosus protein kinase 0.0046 0.0049 0.0033
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Echinococcus multilocularis axis inhibition protein axin 0.0463 0.1525 0.1804
Leishmania major hypothetical protein, conserved 0.0046 0.0049 0.1151
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0112 0.0283 0.0252
Brugia malayi PH domain containing protein 0.0043 0.0036 0.0015
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0157 0.0125
Trypanosoma brucei protein kinase, putative 0.0058 0.0092 0.5131
Entamoeba histolytica protein kinase, putative 0.0046 0.0049 0.0084
Schistosoma mansoni tyrosine kinase 0.0046 0.0049 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0463 0.1525 1
Echinococcus granulosus tyrosine protein kinase csk 0.0046 0.0049 0.0033
Loa Loa (eye worm) uncoordinated protein 104 0.0043 0.0036 0.0033
Entamoeba histolytica protein kinase domain containing protein 0.0068 0.0127 0.0611
Trichomonas vaginalis centaurin/arf, putative 0.0043 0.0036 0.0158
Echinococcus multilocularis geminin 0.0205 0.061 0.0706
Entamoeba histolytica protein kinase domain containing protein 0.0046 0.0049 0.0084
Schistosoma mansoni vav2 0.0043 0.0036 0.0005
Echinococcus multilocularis Oxysterol binding protein 11 0.0043 0.0036 0.0018
Entamoeba histolytica tyrosine kinase, putative 0.0046 0.0049 0.0084
Brugia malayi Immunoglobulin I-set domain containing protein 0.0117 0.0299 0.0278
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0043 0.0036 0.0015
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Onchocerca volvulus Phospholipase A2 homolog 0.0528 0.1753 0.7759
Schistosoma mansoni ephrin receptor 0.0046 0.0049 0.0017
Echinococcus multilocularis mitogen activated protein kinase 3 0.0073 0.0145 0.0148
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0145 0.0114
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0046 0.0049 0.0033
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0081 0.005
Entamoeba histolytica protein kinase domain containing protein 0.0046 0.0049 0.0084
Loa Loa (eye worm) TK/FER protein kinase 0.0046 0.0049 0.0045
Echinococcus granulosus twitchin 0.0124 0.0326 0.0365
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0145 0.0114
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0046 0.0049 0.0028
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0046 0.0049 0.0017
Onchocerca volvulus 0.0046 0.0049 0.0217
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Echinococcus granulosus activated cdc42 kinase 1 0.0046 0.0049 0.0033
Loa Loa (eye worm) hypothetical protein 0.0112 0.0283 0.0279
Entamoeba histolytica tyrosine kinase, putative 0.0046 0.0049 0.0084
Echinococcus granulosus Oxysterol binding protein 11 0.0043 0.0036 0.0018
Echinococcus granulosus tyrosine protein kinase csk 0.0046 0.0049 0.0033
Echinococcus granulosus tyrosine protein kinase Src42A 0.0046 0.0049 0.0033
Schistosoma mansoni plexin 0.0671 0.2259 0.2235
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0046 0.0049 0.0033
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0055 0.0079 0.3973
Brugia malayi Protein kinase domain containing protein 0.0046 0.0049 0.0028
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Brugia malayi ephrin receptor 1 precursor 0.0046 0.0049 0.0028
Echinococcus multilocularis activated cdc42 kinase 1 0.0046 0.0049 0.0033
Trypanosoma cruzi protein kinase, putative 0.0046 0.0049 0.1158
Entamoeba histolytica PH domain containing protein kinase, putative 0.0055 0.0079 0.0289
Brugia malayi Sema domain containing protein 0.0286 0.0896 0.0877
Echinococcus granulosus retinal guanylyl cyclase 2 0.0046 0.0049 0.0033
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0046 0.0049 0.0033
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0055 0.0079 0.3949
Echinococcus granulosus activated cdc42 kinase 1 0.0046 0.0049 0.0033
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0046 0.0049 0.0033
Entamoeba histolytica protein kinase, putative 0.0046 0.0049 0.0084
Schistosoma mansoni tyrosine kinase 0.0046 0.0049 0.0017
Brugia malayi Protein kinase domain containing protein 0.0046 0.0049 0.0028
Schistosoma mansoni protein kinase 0.0058 0.0092 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.0329 0.2089
Schistosoma mansoni centaurin alpha 0.0043 0.0036 0.0005
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0046 0.0049 0.0033
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0046 0.0049 0.0033
Schistosoma mansoni tyrosine kinase 0.0046 0.0049 0.0017
Entamoeba histolytica protein kinase, putative 0.0046 0.0049 0.0084
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0046 0.0049 0.1151
Entamoeba histolytica protein kinase domain containing protein 0.0046 0.0049 0.0084
Brugia malayi Protein kinase domain containing protein 0.0275 0.086 0.084
Entamoeba histolytica cell surface protease gp63, putative 0.0125 0.0329 0.1963
Brugia malayi Protein kinase domain containing protein 0.0046 0.0049 0.0028
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0112 0.0283 0.0252
Schistosoma mansoni tyrosine kinase 0.0046 0.0049 0.0017
Schistosoma mansoni tyrosine kinase 0.0046 0.0049 0.0017
Echinococcus granulosus regulator of G protein signaling 3 0.0463 0.1525 0.1804
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0989 0.6456
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0055 0.0079 0.3973
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0036 0.0158
Loa Loa (eye worm) TK/ACK protein kinase 0.0046 0.0049 0.0045
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.0896 0.1049
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0079 0.0442
Loa Loa (eye worm) hypothetical protein 0.006 0.0099 0.0095
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0043 0.0036 0.0158
Loa Loa (eye worm) TK/FER protein kinase 0.0046 0.0049 0.0045
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0046 0.0049 0.1158
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Loa Loa (eye worm) TK/ROR protein kinase 0.0046 0.0049 0.0045
Loa Loa (eye worm) hypothetical protein 0.0046 0.0049 0.0045
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.2396 0.8361 0.836
Loa Loa (eye worm) RGC/RGC protein kinase 0.0046 0.0049 0.0045
Loa Loa (eye worm) hypothetical protein 0.0112 0.0283 0.0279
Brugia malayi Probable exocyst complex component Sec5 0.0125 0.0329 0.0308
Loa Loa (eye worm) hypothetical protein 0.0043 0.0036 0.0033
Loa Loa (eye worm) hypothetical protein 0.0043 0.0036 0.0033
Brugia malayi MAP kinase sur-1 0.0073 0.0145 0.0124
Entamoeba histolytica tyrosine kinase, putative 0.0046 0.0049 0.0084
Entamoeba histolytica protein kinase domain containing protein 0.0046 0.0049 0.0084
Trichomonas vaginalis guanyl-nucleotide exchange factor, putative 0.0043 0.0036 0.0158
Entamoeba histolytica tyrosine kinase, putative 0.0046 0.0049 0.0084
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0046 0.0049 0.0028
Echinococcus multilocularis epidermal growth factor receptor 0.0046 0.0049 0.0033
Loa Loa (eye worm) TK/INSR protein kinase 0.0046 0.0049 0.0045
Loa Loa (eye worm) TK/FER protein kinase 0.0046 0.0049 0.0045
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0055 0.0079 0.3973
Entamoeba histolytica PH domain containing protein kinase, putative 0.0055 0.0079 0.0289
Echinococcus multilocularis protein tyrosine kinase 0.0046 0.0049 0.0033
Schistosoma mansoni ephrin receptor 0.0051 0.0066 0.0034
Brugia malayi TBC domain containing protein 0.0043 0.0036 0.0015
Loa Loa (eye worm) TK/FER protein kinase 0.0046 0.0049 0.0045
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0055 0.0079 0.3973
Loa Loa (eye worm) TK/FER protein kinase 0.0046 0.0049 0.0045
Loa Loa (eye worm) hypothetical protein 0.0286 0.0896 0.0893
Schistosoma mansoni regulator of G protein signaling 0.0463 0.1525 0.1499
Echinococcus granulosus epidermal growth factor receptor 0.0046 0.0049 0.0033
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0145 0.0149
Schistosoma mansoni hypothetical protein 0.0205 0.061 0.058
Brugia malayi Raf kinase 0.0046 0.0049 0.0028
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0989 0.6456
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.061 0.3948
Brugia malayi Protein kinase domain containing protein 0.0046 0.0049 0.0028
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0046 0.0049 0.0241
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0043 0.0036 0.0033
Entamoeba histolytica tyrosin kinase, putative 0.0171 0.0492 0.3057
Loa Loa (eye worm) hypothetical protein 0.0046 0.0049 0.0045
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0046 0.0049 0.0028
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Loa Loa (eye worm) hypothetical protein 0.0112 0.0283 0.0279
Echinococcus multilocularis cysteine protease atg4b 0.0071 0.0138 0.014
Brugia malayi PH domain containing protein 0.0043 0.0036 0.0015
Brugia malayi Protein kinase domain containing protein 0.0046 0.0049 0.0028
Plasmodium vivax protein kinase, putative 0.0046 0.0049 0.138
Loa Loa (eye worm) AGC/AKT protein kinase 0.0055 0.0079 0.0076
Entamoeba histolytica PH domain containing protein kinase, putative 0.0055 0.0079 0.0289
Echinococcus multilocularis tyrosine protein kinase csk 0.0046 0.0049 0.0033
Schistosoma mansoni tyrosine kinase 0.0046 0.0049 0.0017
Schistosoma mansoni zinc finger protein 0.0043 0.0036 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.0329 0.2089
Entamoeba histolytica hypothetical protein 0.0125 0.0329 0.1963
Schistosoma mansoni dynamin 0.0043 0.0036 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0036 0.0158
Brugia malayi Protein kinase domain containing protein 0.0046 0.0049 0.0028
Entamoeba histolytica hypothetical protein 0.0055 0.0079 0.0289
Echinococcus multilocularis pdz domain containing protein 0.0043 0.0036 0.0018
Entamoeba histolytica protein kinase, putative 0.0046 0.0049 0.0084
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0058 0.0092 0.51
Echinococcus multilocularis Peptidase C54 0.0071 0.0138 0.014
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0071 0.0138 0.0829
Entamoeba histolytica hypothetical protein 0.0046 0.0049 0.0084
Onchocerca volvulus 0.0046 0.0049 0.0217
Loa Loa (eye worm) RGC/RGC protein kinase 0.0046 0.0049 0.0045
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Schistosoma mansoni zinc finger protein 0.0043 0.0036 0.0005
Echinococcus multilocularis ephrin type A receptor 4 A 0.0046 0.0049 0.0033
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0046 0.0049 0.0033
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0046 0.0049 0.0033
Echinococcus multilocularis tyrosine protein kinase csk 0.0046 0.0049 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.0329 0.2089
Loa Loa (eye worm) hypothetical protein 0.0046 0.0049 0.0045
Entamoeba histolytica tyrosine kinase, putative 0.0046 0.0049 0.0084
Schistosoma mansoni tyrosine kinase 0.0046 0.0049 0.0017
Onchocerca volvulus 0.0046 0.0049 0.0217
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Brugia malayi Immunoglobulin I-set domain containing protein 0.0046 0.0049 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0036 0.0158
Schistosoma mansoni tyrosine kinase 0.0046 0.0049 0.0017
Schistosoma mansoni tyrosine kinase 0.0046 0.0049 0.0017
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.061 0.3948
Schistosoma mansoni hypothetical protein 0.0205 0.061 0.058
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0046 0.0049 0.0084
Plasmodium falciparum protein kinase, putative 0.0046 0.0049 0.138
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0145 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0046 0.0049 0.0084
Schistosoma mansoni syntrophin 0.0043 0.0036 0.0005
Loa Loa (eye worm) hypothetical protein 0.0071 0.0138 0.0134
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0043 0.0036 0.0018
Loa Loa (eye worm) TK protein kinase 0.0046 0.0049 0.0045
Loa Loa (eye worm) hypothetical protein 0.0286 0.0896 0.0893
Echinococcus granulosus plexin a4 0.0796 0.2702 0.3215
Schistosoma mansoni regulator of G protein signaling 0.0463 0.1525 0.1499
Brugia malayi SH2 domain containing protein 0.0046 0.0049 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.0329 0.2089
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0989 0.6456
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0073 0.0145 1
Schistosoma mansoni rhogef and pleckstrin domain protein 0.0043 0.0036 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0049 0.0241
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0036 0.0158
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0071 0.0138 0.0829
Loa Loa (eye worm) protein kinase domain-containing protein 0.0046 0.0049 0.0045
Echinococcus granulosus Regulator of G protein signaling 20 0.0463 0.1525 0.1804
Echinococcus multilocularis axis inhibition protein axin 0.0463 0.1525 0.1804
Brugia malayi hypothetical protein 0.0286 0.0896 0.0877
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0046 0.0049 0.0084
Echinococcus multilocularis oxysterol binding protein 9 0.0043 0.0036 0.0018
Loa Loa (eye worm) hypothetical protein 0.0463 0.1525 0.1522
Echinococcus granulosus tyrosine kinase 0.0046 0.0049 0.0033
Loa Loa (eye worm) TK protein kinase 0.0046 0.0049 0.0045
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0079 0.0442
Echinococcus multilocularis protein KINase family member (kin 25) 0.0046 0.0049 0.0033
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0099 0.0078
Loa Loa (eye worm) PXA domain-containing protein 0.0463 0.1525 0.1522
Toxoplasma gondii protein kinase domain-containing protein 0.0055 0.0079 0.3949
Schistosoma mansoni growth factor receptor-bound protein 0.0043 0.0036 0.0005
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0068 0.0127 1
Trichomonas vaginalis STE family protein kinase 0.0046 0.0049 0.0241
Trypanosoma brucei protein kinase, putative 0.0055 0.0079 0.3973
Echinococcus granulosus tyrosine protein kinase Srms 0.0046 0.0049 0.0033
Trypanosoma brucei aurora B kinase 0.0068 0.0127 0.8393
Onchocerca volvulus 0.0043 0.0036 0.0161
Brugia malayi PXA domain containing protein 0.0463 0.1525 0.1507
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0073 0.0145 0.994
Brugia malayi PH domain containing protein 0.0043 0.0036 0.0015
Loa Loa (eye worm) hypothetical protein 0.0046 0.0049 0.0045
Brugia malayi Uncoordinated protein 104 0.0043 0.0036 0.0015
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0046 0.0049 0.0084
Brugia malayi DNA-binding protein LAG-1 0.0125 0.0329 0.0308
Schistosoma mansoni tyrosine kinase 0.0046 0.0049 0.0017
Entamoeba histolytica tyrosin kinase, putative 0.0046 0.0049 0.0084
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0046 0.0049 0.0084
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0145 0.5
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0079 0.0442
Entamoeba histolytica peptidase, C54 family 0.0071 0.0138 0.0682
Entamoeba histolytica protein kinase domain containing protein 0.0171 0.0492 0.3057
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Trypanosoma cruzi Protein kinase B 0.0055 0.0079 0.3973
Echinococcus granulosus c src tyrosine kinase 0.0046 0.0049 0.0033
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.2396 0.8361 0.8357
Onchocerca volvulus 0.0046 0.0049 0.0217
Echinococcus multilocularis tyrosine kinase 0.0046 0.0049 0.0033
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0145 1
Entamoeba histolytica protein kinase domain containing protein 0.0046 0.0049 0.0084
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0046 0.0049 0.0033
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0046 0.0049 0.0033
Entamoeba histolytica protein kinase domain containing protein 0.0046 0.0049 0.0084
Echinococcus multilocularis kinase suppressor of Ras 1 0.0046 0.0049 0.0033
Brugia malayi Protein kinase domain containing protein 0.0046 0.0049 0.0028
Loa Loa (eye worm) hypothetical protein 0.0046 0.0049 0.0045
Echinococcus granulosus mitogen activated protein kinase 3 0.0073 0.0145 0.0148
Schistosoma mansoni tyrosine kinase 0.0046 0.0049 0.0017
Schistosoma mansoni regulator of G protein signaling 0.0463 0.1525 0.1499
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Echinococcus granulosus ephrin type A receptor 4 A 0.0046 0.0049 0.0033
Entamoeba histolytica hypothetical protein 0.0125 0.0329 0.1963
Trichomonas vaginalis AGC family protein kinase 0.0068 0.0127 0.0759
Loa Loa (eye worm) hypothetical protein 0.0286 0.0896 0.0893
Toxoplasma gondii protein kinase 0.0046 0.0049 0.1151
Brugia malayi PH domain containing protein 0.0043 0.0036 0.0015
Schistosoma mansoni tyrosine kinase 0.0046 0.0049 0.0017
Loa Loa (eye worm) AUR protein kinase 0.0068 0.0127 0.0124
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0036 0.0158
Entamoeba histolytica protein kinase, putative 0.0055 0.0079 0.0289
Echinococcus multilocularis integrin linked protein kinase 0.0046 0.0049 0.0033
Brugia malayi hypothetical protein 0.0117 0.0299 0.0278
Entamoeba histolytica protein kinase, putative 0.0055 0.0079 0.0289
Echinococcus granulosus mitogen activated protein kinase 0.0073 0.0145 0.0148
Echinococcus granulosus Pleckstrin y 0.0043 0.0036 0.0018
Loa Loa (eye worm) hypothetical protein 0.0046 0.0049 0.0045
Brugia malayi Tyrosine-protein kinase abl-1 0.0046 0.0049 0.0028
Schistosoma mansoni tyrosine kinase 0.0046 0.0049 0.0017
Onchocerca volvulus 0.0046 0.0049 0.0217
Echinococcus multilocularis FERM and pleckstrin domain containing protein 0.0043 0.0036 0.0018
Onchocerca volvulus 0.0046 0.0049 0.0217
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.0329 0.2089
Echinococcus granulosus Peptidase C54 0.0071 0.0138 0.014
Echinococcus multilocularis regulator of G protein signaling 0.0463 0.1525 0.1804
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0081 0.0072
Trichomonas vaginalis AGC family protein kinase 0.0068 0.0127 0.0759
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0046 0.0049 0.0084
Echinococcus granulosus tyrosine protein kinase Src64B 0.0046 0.0049 0.0033
Brugia malayi Protein kinase domain containing protein 0.0046 0.0049 0.0028
Entamoeba histolytica protein kinase, putative 0.0046 0.0049 0.0084
Echinococcus multilocularis rac serine:threonine kinase 0.0055 0.0079 0.007
Echinococcus granulosus tyrosine protein kinase Fyn 0.0046 0.0049 0.0033
Entamoeba histolytica tyrosin kinase, putative 0.0046 0.0049 0.0084
Brugia malayi regulator of G-protein signaling egl-10 0.0463 0.1525 0.1507
Trichomonas vaginalis TKL family protein kinase 0.0046 0.0049 0.0241
Echinococcus multilocularis GRB2 associated binding protein 3 0.0043 0.0036 0.0018
Loa Loa (eye worm) hypothetical protein 0.0463 0.1525 0.1522
Schistosoma mansoni tyrosine kinase 0.0046 0.0049 0.0017
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0073 0.0145 1
Giardia lamblia Kinase, CMGC MAPK 0.0073 0.0145 1
Trypanosoma cruzi NIMA-related kinase, putative 0.0055 0.0079 0.3973
Schistosoma mansoni dynamin 0.0043 0.0036 0.0005
Entamoeba histolytica protein kinase domain containing protein 0.0046 0.0049 0.0084
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0125 0.0329 0.2089
Echinococcus granulosus beta-adrenergic receptor kinase 0.2192 0.7639 0.9135
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0079 0.0442
Entamoeba histolytica protein kinase domain containing protein 0.0046 0.0049 0.0084
Loa Loa (eye worm) hypothetical protein 0.0046 0.0049 0.0045
Entamoeba histolytica protein kinase, putative 0.0046 0.0049 0.0084
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0055 0.0079 0.3949
Echinococcus multilocularis tyrosine protein kinase pr2 0.0046 0.0049 0.0033

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 10.7 uM PUBCHEM_BIOASSAY: Dose response counterscreen of uHTS hits for ATG4B inhibitors in a Phospholipase A2 assay Set 2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504462, AID504475] ChEMBL. No reference
IC50 (functional) = 19.2 uM PUBCHEM_BIOASSAY: Dose response confirmation of the uHTS fluorescent assay for identification of inhibitors of ATG4B Set 2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504462, AID504475] ChEMBL. No reference
Potency (functional) 1.122 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 2.8022 uM PubChem BioAssay. qHTS for inhibitors of Vif-A3F interactions: Cherry picks. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.5277 uM PubChem BioAssay. qHTS for inhibitors of Vif-A3F interactions: Cherry picks counterscreen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 4.4668 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 4.983 uM PubChem BioAssay. qHTS for inhibitors of Vif-A3G interactions: Cherry picks counterscreen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.0795 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.3078 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.1995 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] ChEMBL. No reference
Potency (functional) 12.9953 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS of GLP-1 Receptor Agonists. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.1093 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (binding) = 56.2341 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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