Detailed information for compound 1414733

Basic information

Technical information
  • TDR Targets ID: 1414733
  • Name: 3-(2,4-dioxo-1H-thieno[3,2-d]pyrimidin-3-yl)- N-(4-methylphenyl)propanamide
  • MW: 329.374 | Formula: C16H15N3O3S
  • H donors: 2 H acceptors: 3 LogP: 1.81 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(cc1)C)CCn1c(=O)[nH]c2c(c1=O)scc2
  • InChi: 1S/C16H15N3O3S/c1-10-2-4-11(5-3-10)17-13(20)6-8-19-15(21)14-12(7-9-23-14)18-16(19)22/h2-5,7,9H,6,8H2,1H3,(H,17,20)(H,18,22)
  • InChiKey: LCYJFRUYZGIOQC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-(2,4-diketo-1H-thieno[3,2-d]pyrimidin-3-yl)-N-(4-methylphenyl)propionamide
  • EU-0089436
  • 3-(2,4-dioxo-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl)-N-(4-methylphenyl)propanamide
  • IDI1_026005
  • SMR000308324
  • MLS000730047
  • ChemDiv3_008095

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens l(3)mbt-like 1 (Drosophila) Starlite/ChEMBL No references
Homo sapiens huntingtin Starlite/ChEMBL No references
Homo sapiens chromobox homolog 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Schistosoma japonicum Lethal(3)malignant brain tumor-like 4 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni hypothetical protein Get druggable targets OG5_130415 All targets in OG5_130415
Schistosoma japonicum Lethal(3)malignant brain tumor-like 3 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.008 0.0099 0.0099
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0066 0.0066 0.0066
Brugia malayi Protein kinase domain containing protein 0.0049 0.0028 0.0023
Onchocerca volvulus 0.0049 0.0028 0.0163
Trypanosoma cruzi NIMA-related kinase, putative 0.0084 0.0106 1
Echinococcus multilocularis Pleckstrin y 0.0066 0.0066 0.0073
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0049 0.0028 0.0028
Schistosoma mansoni hypothetical protein 0.0147 0.0251 0.0238
Echinococcus granulosus exocyst complex component 2 0.0147 0.0251 0.0295
Brugia malayi MAX-1A 0.0066 0.0066 0.0061
Echinococcus granulosus G protein coupled receptor kinase 1 0.2673 0.601 0.7184
Brugia malayi A-kinase anchor protein 10, precursor 0.0717 0.1551 0.1547
Brugia malayi Protein kinase domain containing protein 0.0312 0.0627 0.0622
Echinococcus multilocularis oxysterol binding protein 9 0.0066 0.0066 0.0073
Echinococcus granulosus Rho GTPase activating protein 24 0.0066 0.0066 0.0073
Echinococcus granulosus activated cdc42 kinase 1 0.0049 0.0028 0.0028
Schistosoma mansoni tyrosine kinase 0.0049 0.0028 0.0015
Loa Loa (eye worm) TK/ROR protein kinase 0.0049 0.0028 0.0028
Loa Loa (eye worm) TK protein kinase 0.0049 0.0028 0.0028
Brugia malayi hypothetical protein 0.0336 0.0681 0.0677
Entamoeba histolytica hypothetical protein 0.0084 0.0106 0.0514
Loa Loa (eye worm) RGC/RGC protein kinase 0.0049 0.0028 0.0028
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.0108 0.0108
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0084 0.0106 1
Echinococcus multilocularis tyrosine protein kinase Blk 0.0049 0.0028 0.0028
Echinococcus multilocularis basement membrane specific heparan sulfate 0.008 0.0099 0.0113
Loa Loa (eye worm) hypothetical protein 0.0058 0.0047 0.0047
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0028 0.0031
Entamoeba histolytica protein kinase, putative 0.0084 0.0106 0.0514
Echinococcus granulosus Regulator of G protein signaling 20 0.0717 0.1551 0.1849
Echinococcus granulosus neuroglian 0.008 0.0099 0.0113
Schistosoma mansoni tyrosine kinase 0.0049 0.0028 0.0015
Brugia malayi Protein kinase domain containing protein 0.0049 0.0028 0.0023
Loa Loa (eye worm) hypothetical protein 0.0717 0.1551 0.1551
Onchocerca volvulus 0.0336 0.0681 0.3967
Echinococcus multilocularis kinase suppressor of Ras 1 0.0049 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0336 0.0681 0.0681
Loa Loa (eye worm) TK protein kinase 0.0049 0.0028 0.0028
Onchocerca volvulus 0.0049 0.0028 0.0163
Schistosoma mansoni regulator of G protein signaling 0.0717 0.1551 0.154
Brugia malayi PXA domain containing protein 0.0717 0.1551 0.1547
Brugia malayi Oxysterol-binding protein 0.0066 0.0066 0.0061
Schistosoma mansoni tyrosine kinase 0.0049 0.0028 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0147 0.0251 0.1491
Trichomonas vaginalis TK family protein kinase 0.0049 0.0028 0.0031
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0049 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0066 0.0066 0.0066
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0058 0.0047 0.0034
Brugia malayi PH domain containing protein 0.0066 0.0066 0.0061
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Toxoplasma gondii protein kinase domain-containing protein 0.0084 0.0106 1
Onchocerca volvulus Protein melted homolog 0.0066 0.0066 0.0383
Toxoplasma gondii hypothetical protein 0.0066 0.0066 0.4829
Loa Loa (eye worm) hypothetical protein 0.008 0.0099 0.0099
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0028 0.0015
Schistosoma mansoni tyrosine kinase 0.0049 0.0028 0.0015
Brugia malayi serine/threonine protein kinase 6 0.0077 0.0092 0.0087
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0066 0.0066 0.0248
Trypanosoma brucei aurora B kinase 0.0077 0.0092 0.8137
Schistosoma mansoni hypothetical protein 0.0066 0.0066 0.0053
Loa Loa (eye worm) hypothetical protein 0.0717 0.1551 0.1551
Trichomonas vaginalis conserved hypothetical protein 0.0717 0.1551 1
Trichomonas vaginalis protein kinase atn1, putative 0.0049 0.0028 0.0031
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Schistosoma mansoni oxysterol-binding protein 1 0.0066 0.0066 0.0053
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0066 0.0066 0.0248
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Schistosoma mansoni protein kinase 0.0049 0.0028 0.0015
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0049 0.0028 0.0028
Schistosoma mansoni tyrosine kinase 0.0049 0.0028 0.0015
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0084 0.0106 1
Trichomonas vaginalis conserved hypothetical protein 0.0147 0.0251 0.1491
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0054 0.0039 0.0041
Brugia malayi Plexin repeat family protein 0.079 0.1717 0.1713
Brugia malayi hypothetical protein 0.0049 0.0028 0.0023
Onchocerca volvulus Tyrosine kinase homolog 0.0049 0.0028 0.0163
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0028 0.0028
Onchocerca volvulus 0.0049 0.0028 0.0163
Echinococcus granulosus tyrosine protein kinase Fyn 0.0049 0.0028 0.0028
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0049 0.0028 0.0028
Schistosoma mansoni hypothetical protein 0.0147 0.0251 0.0238
Schistosoma mansoni guanyl-nucleotide exchange factor 0.0066 0.0066 0.0053
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0049 0.0028 0.0028
Brugia malayi PH domain containing protein 0.0066 0.0066 0.0061
Loa Loa (eye worm) hypothetical protein 0.0066 0.0066 0.0066
Leishmania major serine/threonine-protein kinase a, putative 0.0084 0.0106 1
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0049 0.0028 0.0015
Echinococcus multilocularis transcription factor collier 0.0147 0.0251 0.0295
Entamoeba histolytica hypothetical protein, conserved 0.0066 0.0066 0.0248
Echinococcus granulosus tyrosine kinase 0.0049 0.0028 0.0028
Entamoeba histolytica hypothetical protein 0.0147 0.0251 0.1465
Echinococcus multilocularis protein kinase 0.0049 0.0028 0.0028
Echinococcus multilocularis neuroglian 0.008 0.0099 0.0113
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Trypanosoma brucei rac serine-threonine kinase, putative 0.0084 0.0106 1
Schistosoma mansoni protein tyrosine kinase 0.0049 0.0028 0.0015
Brugia malayi Protein kinase domain containing protein 0.0049 0.0028 0.0023
Schistosoma mansoni serine/threonine protein kinase 0.4423 1 1
Trypanosoma cruzi hypothetical protein 0.0066 0.0066 0.4829
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.4423 1 1
Entamoeba histolytica PH domain containing protein 0.0066 0.0066 0.0248
Echinococcus multilocularis tyrosine protein kinase csk 0.0049 0.0028 0.0028
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0077 0.0092 0.0418
Brugia malayi Protein kinase domain containing protein 0.0049 0.0028 0.0023
Echinococcus multilocularis rac serine:threonine kinase 0.0084 0.0106 0.0121
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0066 0.0066 0.4829
Entamoeba histolytica PH domain containing protein kinase, putative 0.0084 0.0106 0.0514
Schistosoma mansoni protein kinase 0.0049 0.0028 0.0015
Onchocerca volvulus 0.0049 0.0028 0.0163
Echinococcus multilocularis oxysterol binding protein 3 0.0066 0.0066 0.0073
Onchocerca volvulus 0.0049 0.0028 0.0163
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0028 0.0028
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0084 0.0106 1
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0066 0.0066 0.0248
Echinococcus granulosus SAM and MBT domain containing protein 0.0058 0.0047 0.0051
Echinococcus granulosus tyrosine protein kinase ABL1 0.0049 0.0028 0.0028
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Loa Loa (eye worm) TK protein kinase 0.0049 0.0028 0.0028
Brugia malayi Dynamin 0.0066 0.0066 0.0061
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0049 0.0028 0.0028
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0717 0.1551 0.1849
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0066 0.0066 0.0053
Echinococcus multilocularis aurora kinase A 0.0077 0.0092 0.0104
Toxoplasma gondii AtPH1 family protein 0.0066 0.0066 0.4829
Loa Loa (eye worm) hypothetical protein 0.0085 0.011 0.011
Schistosoma mansoni goodpasture antigen-binding protein 0.0066 0.0066 0.0053
Schistosoma mansoni tyrosine kinase 0.0049 0.0028 0.0015
Schistosoma mansoni centaurin alpha 0.0066 0.0066 0.0053
Brugia malayi Receptor family ligand binding region containing protein 0.0049 0.0028 0.0023
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0049 0.0028 0.0163
Loa Loa (eye worm) hypothetical protein 0.0148 0.0253 0.0253
Loa Loa (eye worm) AUR protein kinase 0.0077 0.0092 0.0092
Schistosoma mansoni vesicular amine transporter 0.0083 0.0105 0.0092
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0227 0.0433 0.0513
Trypanosoma cruzi aurora B kinase, putative 0.0077 0.0092 0.8137
Loa Loa (eye worm) TK/FAK protein kinase 0.0049 0.0028 0.0028
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0066 0.0066 0.0066
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0106 0.0543
Echinococcus multilocularis collagen type iv alpha 3 binding protein 0.0066 0.0066 0.0073
Trypanosoma cruzi PH domain containing protein, putative 0.0066 0.0066 0.4829
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0077 0.0092 0.0418
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0084 0.0106 1
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Schistosoma mansoni tyrosine kinase 0.0049 0.0028 0.0015
Entamoeba histolytica PH domain containing protein kinase, putative 0.0084 0.0106 0.0514
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0066 0.0278
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0227 0.0433 0.0513
Echinococcus granulosus epidermal growth factor receptor 0.0049 0.0028 0.0028
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0106 0.0543
Schistosoma mansoni tyrosine kinase 0.0049 0.0028 0.0015
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Loa Loa (eye worm) hypothetical protein 0.079 0.1717 0.1717
Trypanosoma cruzi PH domain containing protein, putative 0.0066 0.0066 0.4829
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Brugia malayi PH domain containing protein 0.0066 0.0066 0.0061
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0028 0.0028
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0077 0.0092 0.8137
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0106 0.0543
Echinococcus multilocularis Immunoglobulin 0.008 0.0099 0.0113
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Loa Loa (eye worm) TK/EPH protein kinase 0.0049 0.0028 0.0028
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0077 0.0092 0.0104
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0066 0.0278
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.3706 0.8365 0.8364
Brugia malayi regulator of G-protein signaling rgs-7 0.0717 0.1551 0.1547
Loa Loa (eye worm) hypothetical protein 0.0066 0.0066 0.0066
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0028 0.0028
Brugia malayi Protein kinase domain containing protein 0.0049 0.0028 0.0023
Onchocerca volvulus 0.0066 0.0066 0.0383
Loa Loa (eye worm) TK/KIN16 protein kinase 0.013 0.0211 0.0211
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0028 0.0028
Echinococcus multilocularis Regulator of G protein signaling 20 0.0717 0.1551 0.1849
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0049 0.0028 0.0028
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0066 0.0066 0.0278
Schistosoma mansoni vav2 0.0066 0.0066 0.0053
Brugia malayi Protein kinase domain containing protein 0.0049 0.0028 0.0023
Onchocerca volvulus Putative neuronal RhoA GEF protein 0.0066 0.0066 0.0383
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0066 0.0066 0.0248
Echinococcus multilocularis Ras associated and pleckstrin y 0.0066 0.0066 0.0073
Loa Loa (eye worm) hypothetical protein 0.0066 0.0066 0.0066
Brugia malayi Tyrosine-protein kinase abl-1 0.0049 0.0028 0.0023
Loa Loa (eye worm) AGC/AKT protein kinase 0.0084 0.0106 0.0106
Loa Loa (eye worm) TK protein kinase 0.0049 0.0028 0.0028
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0049 0.0028 0.0031
Onchocerca volvulus 0.0049 0.0028 0.0163
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0049 0.0028 0.0028
Brugia malayi Oxysterol binding protein 0.0066 0.0066 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0066 0.0278
Echinococcus granulosus regulator of G protein signaling 3 0.0717 0.1551 0.1849
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0066 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.008 0.0099 0.0099
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0084 0.0106 1
Schistosoma mansoni dynamin 0.0066 0.0066 0.0053
Loa Loa (eye worm) hypothetical protein 0.0717 0.1551 0.1551
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Schistosoma mansoni tyrosine kinase 0.0049 0.0028 0.0015
Onchocerca volvulus 0.0066 0.0066 0.0383
Loa Loa (eye worm) RGC/RGC protein kinase 0.0049 0.0028 0.0028
Trypanosoma cruzi Protein kinase B 0.0084 0.0106 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0084 0.0106 0.0514
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0084 0.0106 1
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0049 0.0028 0.0023
Trichomonas vaginalis centaurin/arf, putative 0.0066 0.0066 0.0278
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0106 0.0543
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0106 0.0543
Echinococcus multilocularis tyrosine kinase 0.0049 0.0028 0.0028
Loa Loa (eye worm) TK/ACK protein kinase 0.0049 0.0028 0.0028
Brugia malayi hypothetical protein 0.0049 0.0028 0.0023
Brugia malayi Guanylyl cyclase protein 23 0.0049 0.0028 0.0023
Schistosoma mansoni serine/threonine protein kinase 0.339 0.7646 0.7642
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0066 0.0278
Schistosoma mansoni dynamin 0.0066 0.0066 0.0053
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0028 0.0028
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0028 0.0028
Brugia malayi hypothetical protein 0.0085 0.011 0.0105
Onchocerca volvulus Abnormal cell migration protein 10 homolog 0.0066 0.0066 0.0383
Schistosoma mansoni protein kinase 0.0067 0.0068 0.0056
Schistosoma mansoni tyrosine kinase 0.0049 0.0028 0.0015
Echinococcus multilocularis exocyst complex component 2 0.0147 0.0251 0.0295
Echinococcus granulosus tyrosine protein kinase Src64B 0.0049 0.0028 0.0028
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0084 0.0106 1
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.3706 0.8365 1
Schistosoma mansoni tyrosine kinase 0.0049 0.0028 0.0015
Loa Loa (eye worm) TK protein kinase 0.0049 0.0028 0.0028
Entamoeba histolytica protein kinase , putative 0.0077 0.0092 0.0418
Brugia malayi IPT/TIG domain containing protein 0.0147 0.0251 0.0246
Echinococcus granulosus c src tyrosine kinase 0.0049 0.0028 0.0028
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0066 0.0066 0.0248
Loa Loa (eye worm) hypothetical protein 0.0049 0.0028 0.0028
Entamoeba histolytica hypothetical protein 0.0147 0.0251 0.1465
Loa Loa (eye worm) hypothetical protein 0.0717 0.1551 0.1551
Loa Loa (eye worm) hypothetical protein 0.0066 0.0066 0.0066
Echinococcus multilocularis tyrosine protein kinase csk 0.0049 0.0028 0.0028
Echinococcus granulosus tyrosine protein kinase 0.0049 0.0028 0.0028
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0106 0.0543
Brugia malayi Protein kinase domain containing protein 0.0049 0.0028 0.0023
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0084 0.0106 1
Brugia malayi C-terminal src kinase protein 1 0.0049 0.0028 0.0023
Brugia malayi Protein kinase domain containing protein 0.0049 0.0028 0.0023
Echinococcus granulosus oxysterol binding protein 1 0.0066 0.0066 0.0073
Echinococcus granulosus tyrosine protein kinase csk 0.0049 0.0028 0.0028
Onchocerca volvulus 0.0066 0.0066 0.0383
Schistosoma mansoni tyrosine kinase 0.0049 0.0028 0.0015
Onchocerca volvulus 0.0049 0.0028 0.0163
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0049 0.0028 0.0028
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0066 0.0278
Loa Loa (eye worm) hypothetical protein 0.008 0.0099 0.0099
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0031 0.0053
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Toxoplasma gondii Oxysterol-binding protein 0.0066 0.0066 0.4829
Schistosoma mansoni myelin transcription factor 1 myt1 0.0066 0.0065 0.0052
Trypanosoma cruzi hypothetical protein 0.0066 0.0066 0.4829
Brugia malayi Immunoglobulin I-set domain containing protein 0.0085 0.011 0.0105
Brugia malayi hypothetical protein 0.0049 0.0028 0.0023
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0106 0.0543
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0108 0.0552
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0028 0.0028
Loa Loa (eye worm) TK protein kinase 0.0049 0.0028 0.0028
Echinococcus granulosus insulin receptor 0.0049 0.0028 0.0028
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0049 0.0028 0.0028
Brugia malayi Protein kinase domain containing protein 0.0049 0.0028 0.0023
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0067 0.0068 0.5171
Echinococcus multilocularis plexin a4 0.0937 0.2052 0.2449
Echinococcus granulosus collagen type iv alpha 3 binding protein 0.0066 0.0066 0.0073
Brugia malayi Uncoordinated protein 104 0.0066 0.0066 0.0061
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Schistosoma mansoni syntrophin 0.0066 0.0066 0.0053
Loa Loa (eye worm) hypothetical protein 0.0049 0.0028 0.0028
Echinococcus multilocularis myotubularin protein 13 0.0066 0.0066 0.0073
Loa Loa (eye worm) hypothetical protein 0.0066 0.0066 0.0066
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0067 0.0068 0.5171
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0066 0.0278
Brugia malayi ephrin receptor 1 precursor 0.0049 0.0028 0.0023
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Schistosoma mansoni rhogef and pleckstrin domain protein 0.0066 0.0066 0.0053
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0066 0.0066 0.0248
Brugia malayi hypothetical protein 0.0336 0.0681 0.0677
Loa Loa (eye worm) hypothetical protein 0.0066 0.0066 0.0066
Schistosoma mansoni protein kinase 0.0049 0.0028 0.0015
Entamoeba histolytica hypothetical protein 0.0066 0.0066 0.0248
Loa Loa (eye worm) protein kinase domain-containing protein 0.0049 0.0028 0.0028
Brugia malayi Protein kinase domain containing protein 0.0084 0.0106 0.0102
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0058 0.0047 0.0274
Entamoeba histolytica hypothetical protein 0.0066 0.0066 0.0248
Leishmania major protein kinase, putative 0.0077 0.0092 0.8137
Schistosoma mansoni tyrosine kinase 0.0049 0.0028 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0066 0.0278
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0031 0.0053
Brugia malayi Protein kinase domain containing protein 0.0049 0.0028 0.0023
Loa Loa (eye worm) hypothetical protein 0.0066 0.0066 0.0066
Echinococcus granulosus tyrosine protein kinase Lyn 0.0067 0.0068 0.0076
Brugia malayi integrin-linked kinase 0.0049 0.0028 0.0023
Echinococcus granulosus calcium dependent secretion activator 1 0.0066 0.0066 0.0073
Schistosoma mansoni oxysterol-binding protein 1 0.0066 0.0066 0.0053
Schistosoma mansoni tyrosine kinase 0.0049 0.0028 0.0015
Echinococcus multilocularis tyrosine protein kinase Abl 0.0049 0.0028 0.0028
Echinococcus multilocularis epidermal growth factor receptor 0.0049 0.0028 0.0028
Echinococcus multilocularis tyrosine protein kinase csk 0.0049 0.0028 0.0028
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0049 0.0028 0.0023
Brugia malayi chromobox protein homolog 3 0.0047 0.0023 0.0019
Onchocerca volvulus outspread protein homolog 0.0066 0.0066 0.0383
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0049 0.0028 0.0028
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0106 0.0543
Echinococcus multilocularis transfer RNA-Thr 0.0049 0.0028 0.0028
Schistosoma mansoni zinc finger protein 0.0066 0.0066 0.0053
Entamoeba histolytica tyrosin kinase, putative 0.0196 0.0363 0.2202
Onchocerca volvulus 0.0049 0.0028 0.0163
Toxoplasma gondii aurora kinase 0.0077 0.0092 0.8137
Echinococcus granulosus type II inositol 34 bisphosphate 4 phosphatase 0.0066 0.0066 0.0073
Schistosoma mansoni growth factor receptor-bound protein 0.0066 0.0066 0.0053
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0028 0.0028
Brugia malayi Fibronectin type III domain containing protein 0.0085 0.011 0.0105
Trichomonas vaginalis conserved hypothetical protein 0.0147 0.0251 0.1491
Brugia malayi protein-tyrosine kinase 0.0049 0.0028 0.0023
Brugia malayi serine/threonine kinase 12 0.0077 0.0092 0.0087
Loa Loa (eye worm) hypothetical protein 0.0336 0.0681 0.0681
Trichomonas vaginalis protein transport protein sec7, putative 0.0066 0.0066 0.0278
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0066 0.0065 0.0061
Plasmodium vivax hypothetical protein, conserved 0.0066 0.0066 0.4829
Brugia malayi hypothetical protein 0.0717 0.1551 0.1547
Echinococcus granulosus cytohesin 1 0.0066 0.0066 0.0073
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0106 0.0543
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Brugia malayi Dynamin 0.0066 0.0066 0.0061
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Brugia malayi hypothetical protein 0.0717 0.1551 0.1547
Loa Loa (eye worm) sema domain-containing protein 0.0336 0.0681 0.0681
Echinococcus multilocularis expressed protein 0.0717 0.1551 0.1849
Onchocerca volvulus 0.0058 0.0047 0.0274
Leishmania major protein kinase, putative 0.0067 0.0068 0.5171
Loa Loa (eye worm) TK/ALK protein kinase 0.0312 0.0627 0.0627
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0066 0.0278
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0049 0.0028 0.0028
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0049 0.0028 0.0028
Echinococcus granulosus epidermal growth factor receptor 0.0049 0.0028 0.0028
Echinococcus multilocularis histone acetyltransferase MYST2 0.0066 0.0065 0.0072
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0049 0.0028 0.0028
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.3706 0.8365 0.8365
Brugia malayi Immunoglobulin I-set domain containing protein 0.0049 0.0028 0.0023
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0066 0.0066 0.0278
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Echinococcus granulosus tyrosine protein kinase csk 0.0049 0.0028 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0028 0.0031
Loa Loa (eye worm) RGC/RGC protein kinase 0.0049 0.0028 0.0028
Leishmania major protein kinase, putative 0.0084 0.0106 1
Trichomonas vaginalis conserved hypothetical protein 0.0147 0.0251 0.1491
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0106 0.0543
Trichomonas vaginalis AGC family protein kinase 0.0077 0.0092 0.0447
Brugia malayi Protein kinase domain containing protein 0.0049 0.0028 0.0023
Plasmodium vivax PH domain containing protein 0.0066 0.0066 0.4829
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0049 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0049 0.0028 0.0028
Brugia malayi PH domain containing protein 0.0066 0.0066 0.0061
Entamoeba histolytica PH domain containing protein 0.0066 0.0066 0.0248
Loa Loa (eye worm) TK/ABL protein kinase 0.0049 0.0028 0.0028
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Echinococcus multilocularis epidermal growth factor receptor 0.0049 0.0028 0.0028
Echinococcus multilocularis pdz domain containing protein 0.0066 0.0066 0.0073
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.0031 0.0183
Trichomonas vaginalis development and differentiation-enhancing factor, ddef, putative 0.0066 0.0066 0.0278
Echinococcus granulosus beta 1 syntrophin 0.0066 0.0066 0.0073
Trichomonas vaginalis hypothetical protein 0.0066 0.0066 0.0278
Entamoeba histolytica ARF GTPase activating protein, putative 0.0066 0.0066 0.0248
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0049 0.0028 0.0028
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0049 0.0028 0.0028
Brugia malayi mbt repeat family protein 0.0058 0.0047 0.0042
Schistosoma mansoni regulator of G protein signaling 0.0717 0.1551 0.154
Loa Loa (eye worm) Plekhf2 protein 0.0066 0.0066 0.0066
Brugia malayi Protein kinase domain containing protein 0.0049 0.0028 0.0023
Echinococcus granulosus transcription factor collier 0.0147 0.0251 0.0295
Echinococcus granulosus ras specific guanine nucleotide releasing factor 0.0066 0.0066 0.0073
Loa Loa (eye worm) hypothetical protein 0.0066 0.0066 0.0066
Entamoeba histolytica hypothetical protein 0.0066 0.0066 0.0248
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0028 0.0031
Schistosoma mansoni tyrosine kinase 0.0049 0.0028 0.0015
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0049 0.0028 0.0028
Trichomonas vaginalis centaurin beta, putative 0.0066 0.0066 0.0278
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0717 0.1551 0.1551
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0106 0.0543
Echinococcus multilocularis Rho GTPase activating protein 24 0.0066 0.0066 0.0073
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0336 0.0681 0.0681
Echinococcus multilocularis beta adrenergic receptor kinase 0.339 0.7646 0.9139
Schistosoma mansoni chromobox protein 0.0084 0.0108 0.0095
Trichomonas vaginalis AGC family protein kinase 0.0077 0.0092 0.0447
Loa Loa (eye worm) hypothetical protein 0.0147 0.0251 0.0251
Schistosoma mansoni regulator of G protein signaling 0.0717 0.1551 0.154
Echinococcus granulosus polycomb protein SCMH1 0.0058 0.0047 0.0051
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Loa Loa (eye worm) hypothetical protein 0.0049 0.0028 0.0028
Echinococcus multilocularis ephrin type A receptor 4 A 0.0049 0.0028 0.0028
Onchocerca volvulus Huntingtin homolog 0.0148 0.0253 0.1474
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0049 0.0028 0.0028
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0049 0.0028 0.0028
Entamoeba histolytica hypothetical protein 0.0147 0.0251 0.1465
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0084 0.0106 1
Trichomonas vaginalis conserved hypothetical protein 0.0147 0.0251 0.1491
Schistosoma mansoni myotubularin-related protein 0.0066 0.0066 0.0053
Echinococcus multilocularis tyrosine protein kinase csk 0.0049 0.0028 0.0028
Brugia malayi Variant SH3 domain containing protein 0.0066 0.0066 0.0061
Trypanosoma cruzi hypothetical protein 0.0066 0.0066 0.4829
Echinococcus granulosus natriuretic peptide receptor 1 0.0049 0.0028 0.0028
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0067 0.0068 0.5171
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0049 0.0028 0.0028
Brugia malayi PH domain containing protein 0.0066 0.0066 0.0061
Loa Loa (eye worm) uncoordinated protein 104 0.0066 0.0066 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0066 0.0278
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0028 0.0028
Echinococcus granulosus Pleckstrin y 0.0066 0.0066 0.0073
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0108 0.0552
Schistosoma mansoni ephrin receptor 0.0049 0.0028 0.0015
Trichomonas vaginalis centaurin gamma, putative 0.0066 0.0066 0.0278
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0106 0.0543
Echinococcus multilocularis Immunoglobulin 0.008 0.0099 0.0113
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0106 0.0543
Loa Loa (eye worm) hypothetical protein 0.0085 0.011 0.011
Onchocerca volvulus 0.0066 0.0066 0.0383
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0084 0.0106 0.0543
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0039 0.0005 0.0005
Trypanosoma brucei PH domain containing protein, putative 0.0066 0.0066 0.4829
Echinococcus multilocularis DCC interacting protein 13 beta 0.0066 0.0066 0.0073
Schistosoma mansoni hypothetical protein 0.0049 0.0028 0.0015
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0106 0.0543
Brugia malayi Protein kinase domain containing protein 0.0049 0.0028 0.0023
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0049 0.0028 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0066 0.0278
Brugia malayi Variant SH3 domain containing protein 0.0066 0.0066 0.0061
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0084 0.0106 1
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Onchocerca volvulus 0.0049 0.0028 0.0163
Schistosoma mansoni Neurotrimin precursor (hNT) 0.008 0.0099 0.0086
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.008 0.0099 0.0113
Echinococcus multilocularis activin receptor type 0.0067 0.0068 0.0076
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0049 0.0028 0.0015
Echinococcus granulosus Immunoglobulin 0.008 0.0099 0.0113
Entamoeba histolytica protein kinase, putative 0.0077 0.0092 0.0418
Brugia malayi Protein kinase domain containing protein 0.0049 0.0028 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0717 0.1551 1
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0066 0.0066 0.0073
Entamoeba histolytica protein kinase, putative 0.0077 0.0092 0.0418
Brugia malayi Pleckstrin Homology Domain 0.0066 0.0066 0.0061
Entamoeba histolytica protein kinase domain containing protein 0.0196 0.0363 0.2202
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Schistosoma mansoni tyrosine kinase 0.0049 0.0028 0.0015
Loa Loa (eye worm) hypothetical protein 0.0049 0.0028 0.0028
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0028 0.0028
Loa Loa (eye worm) TK/DDR protein kinase 0.0049 0.0028 0.0028
Brugia malayi Tyrosine-protein kinase PR2 0.0049 0.0028 0.0023
Schistosoma mansoni tyrosine kinase 0.0049 0.0028 0.0015
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0066 0.0066 0.0248
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Echinococcus multilocularis heat shock protein 70 0.0049 0.0028 0.0028
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Schistosoma mansoni serine/threonine RGC 0.0049 0.0028 0.0015
Echinococcus multilocularis calcium dependent secretion activator 1 0.0066 0.0066 0.0073
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Loa Loa (eye worm) hypothetical protein 0.0085 0.011 0.011
Brugia malayi SRC-1 0.0049 0.0028 0.0023
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0066 0.0066 0.0248
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0049 0.0028 0.0028
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0066 0.0066 0.0248
Brugia malayi mbt repeat family protein 0.0058 0.0047 0.0042
Schistosoma mansoni tyrosine kinase 0.0049 0.0028 0.0015
Echinococcus granulosus Pleckstrin y 0.0066 0.0066 0.0073
Loa Loa (eye worm) hypothetical protein 0.0049 0.0028 0.0028
Echinococcus multilocularis actin binding protein anillin 0.0066 0.0066 0.0073
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0066 0.0066 0.4829
Brugia malayi SH2 domain containing protein 0.0049 0.0028 0.0023
Brugia malayi Protein kinase domain containing protein 0.0049 0.0028 0.0023
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0028 0.0028
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0066 0.0065 0.0072
Leishmania major hypothetical protein, conserved 0.0066 0.0066 0.4829
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0049 0.0028 0.0028
Loa Loa (eye worm) RGC/RGC protein kinase 0.0049 0.0028 0.0028
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0066 0.0065 0.0072
Schistosoma mansoni z-protein (S1r protein) 0.0717 0.1551 0.154
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0028 0.0031
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0106 0.0543
Loa Loa (eye worm) syntrophin-1 0.0066 0.0066 0.0066
Echinococcus multilocularis regulator of G protein signaling 7 0.0717 0.1551 0.1849
Brugia malayi hypothetical protein 0.0148 0.0253 0.0248
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0049 0.0028 0.0028
Schistosoma mansoni tyrosine kinase 0.0049 0.0028 0.0015
Schistosoma mansoni serine/threonine-protein kinase 0.0084 0.0106 0.0093
Brugia malayi Syntrophin-1 0.0066 0.0066 0.0061
Plasmodium falciparum oxysterol-binding protein, putative 0.0066 0.0066 0.4829
Brugia malayi serine/threonine-protein kinase 6 0.0077 0.0092 0.0087
Schistosoma mansoni hypothetical protein 0.0066 0.0066 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.0717 0.1551 1
Schistosoma mansoni ephrin receptor 0.0054 0.0039 0.0026
Echinococcus multilocularis tyrosine protein kinase 0.0049 0.0028 0.0028
Loa Loa (eye worm) TK/EGFR protein kinase 0.0049 0.0028 0.0028
Echinococcus granulosus receptor type guanylyl cyclase 0.0049 0.0028 0.0028
Loa Loa (eye worm) TK protein kinase 0.0049 0.0028 0.0028
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0049 0.0028 0.0028
Brugia malayi PH domain containing protein 0.0066 0.0066 0.0061
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0717 0.1551 0.154
Trichomonas vaginalis centaurin alpha, putative 0.0066 0.0066 0.0278
Echinococcus granulosus integrin linked protein kinase 0.0049 0.0028 0.0028
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0066 0.0066 0.0248
Brugia malayi GTPase-activator protein for Ras-like GTPase containing protein 0.0066 0.0066 0.0061
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Entamoeba histolytica protein kinase, putative 0.0084 0.0106 0.0514
Echinococcus multilocularis protein kinase 0.0049 0.0028 0.0028
Schistosoma mansoni tyrosine kinase 0.0049 0.0028 0.0015
Trypanosoma cruzi PH domain containing protein, putative 0.0066 0.0066 0.4829
Brugia malayi Protein kinase domain containing protein 0.0049 0.0028 0.0023
Echinococcus granulosus DCC interacting protein 13 beta 0.0066 0.0066 0.0073
Echinococcus multilocularis regulator of G protein signaling 3 0.0717 0.1551 0.1849
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0049 0.0028 0.0028
Brugia malayi regulator of G-protein signaling egl-10 0.0717 0.1551 0.1547
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0106 0.0543
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Schistosoma mansoni semaphorin 5-related 0.0336 0.0681 0.0669
Echinococcus multilocularis tyrosine kinase 0.0049 0.0028 0.0028
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0106 0.0543
Loa Loa (eye worm) AUR protein kinase 0.0077 0.0092 0.0092
Loa Loa (eye worm) PXA domain-containing protein 0.0717 0.1551 0.1551
Echinococcus multilocularis tyrosine protein kinase shark 0.0049 0.0028 0.0028
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0049 0.0028 0.0015
Brugia malayi Protein kinase domain containing protein 0.0049 0.0028 0.0023
Brugia malayi Raf kinase 0.0049 0.0028 0.0023
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Brugia malayi Sema domain containing protein 0.0336 0.0681 0.0677
Plasmodium falciparum calcium-dependent protein kinase 7 0.0084 0.0106 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.0065 0.0065
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0084 0.0106 1
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0717 0.1551 0.1849
Echinococcus multilocularis FERM and pleckstrin domain containing protein 0.0066 0.0066 0.0073
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0049 0.0028 0.0028
Entamoeba histolytica protein kinase domain containing protein 0.0077 0.0092 0.0418
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0047 0.0034
Entamoeba histolytica cell surface protease gp63, putative 0.0147 0.0251 0.1465
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0049 0.0028 0.0015
Loa Loa (eye worm) hypothetical protein 0.0066 0.0066 0.0066
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0084 0.0106 1
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.0066 0.0066 0.0073
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Entamoeba histolytica PH domain containing protein kinase, putative 0.0084 0.0106 0.0514
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0049 0.0028 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0717 0.1551 1
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0067 0.0068 0.5171
Trichomonas vaginalis STE family protein kinase 0.0049 0.0028 0.0031
Schistosoma mansoni hypothetical protein 0.0066 0.0066 0.0053
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0049 0.0028 0.0023
Leishmania major protein kinase, putative 0.0084 0.0106 1
Entamoeba histolytica protein kinase domain containing protein 0.0067 0.0068 0.0266
Schistosoma mansoni protein kinase 0.0049 0.0028 0.0015
Entamoeba histolytica protein kinase, putative 0.0084 0.0106 0.0514
Loa Loa (eye worm) hypothetical protein 0.0454 0.0952 0.0952
Loa Loa (eye worm) hypothetical protein 0.0066 0.0066 0.0066
Echinococcus granulosus axis inhibition protein axin 0.0717 0.1551 0.1849
Plasmodium falciparum acylated pleckstrin-homology domain-containing protein, putative 0.0066 0.0066 0.4829
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0066 0.0066 0.4829
Loa Loa (eye worm) hypothetical protein 0.0066 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0049 0.0028 0.0028
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Entamoeba histolytica hypothetical protein 0.0147 0.0251 0.1465
Echinococcus granulosus serine/threonine protein kinase 0.0084 0.0106 0.0121
Loa Loa (eye worm) hypothetical protein 0.0049 0.0028 0.0028
Echinococcus multilocularis dynamin 1 0.0066 0.0066 0.0073
Schistosoma mansoni protein kinase 0.0049 0.0028 0.0015
Trypanosoma cruzi PH domain containing protein, putative 0.0066 0.0066 0.4829
Trichomonas vaginalis conserved hypothetical protein 0.0147 0.0251 0.1491
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0049 0.0028 0.0028
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0147 0.0251 0.1491
Giardia lamblia Aurora kinase 0.0077 0.0092 1
Echinococcus multilocularis ras specific guanine nucleotide releasing factor 0.0066 0.0066 0.0073
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0047 0.0034
Trichomonas vaginalis AGC family protein kinase 0.0077 0.0092 0.0447
Loa Loa (eye worm) oxysterol binding protein 0.0066 0.0066 0.0066
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0066 0.0066 0.0061
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0106 0.0543
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0049 0.0028 0.0028
Echinococcus granulosus retinal guanylyl cyclase 2 0.0049 0.0028 0.0028
Brugia malayi probable spectrin beta chain 0.0066 0.0066 0.0061
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0066 0.0066 0.0073
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0049 0.0028 0.0015
Echinococcus granulosus retinal guanylyl cyclase 2 0.0049 0.0028 0.0028
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0028 0.0015
Schistosoma mansoni hypothetical protein 0.035 0.0714 0.0702
Brugia malayi bone morphogenetic protein type 1 receptor 0.0049 0.0028 0.0023
Echinococcus multilocularis protein tyrosine kinase 0.0049 0.0028 0.0028
Echinococcus granulosus regulator of G protein signaling 7 0.0717 0.1551 0.1849
Brugia malayi Furin-like cysteine rich region family protein 0.0049 0.0028 0.0023
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Loa Loa (eye worm) hypothetical protein 0.0066 0.0066 0.0066
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0049 0.0028 0.0015
Echinococcus granulosus retinal guanylyl cyclase 2 0.0049 0.0028 0.0028
Echinococcus granulosus tyrosine protein kinase Blk 0.0049 0.0028 0.0028
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0049 0.0028 0.0028
Brugia malayi PH domain containing protein 0.0066 0.0066 0.0061
Schistosoma mansoni protein kinase 0.0049 0.0028 0.0015
Echinococcus multilocularis tyrosine protein kinase HCK 0.0049 0.0028 0.0028
Entamoeba histolytica protein kinase, putative 0.0084 0.0106 0.0514
Schistosoma mansoni plexin 0.0454 0.0952 0.094
Schistosoma mansoni axis inhibition protein axin 0.0717 0.1551 0.154
Loa Loa (eye worm) hypothetical protein 0.0336 0.0681 0.0681
Echinococcus granulosus chromobox protein 1 0.0084 0.0108 0.0123
Echinococcus granulosus defective proboscis extension response 0.008 0.0099 0.0113
Trichomonas vaginalis protein transport protein sec7, putative 0.0066 0.0066 0.0278
Echinococcus multilocularis regulator of G protein signaling 0.0717 0.1551 0.1849
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0106 0.0543
Echinococcus multilocularis Pleckstrin domain containing protein, family B 0.0066 0.0066 0.0073
Echinococcus granulosus semaphorin 5B 0.0336 0.0681 0.0809
Echinococcus multilocularis regulator of G protein signaling 7 0.0717 0.1551 0.1849
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0023 0.0135
Schistosoma mansoni serine/threonine protein kinase 0.0077 0.0092 0.0079
Schistosoma mansoni serine/threonine protein kinase 0.339 0.7646 0.7642
Echinococcus multilocularis arf GAP with coiled coil, ANK repeat and PH 0.0066 0.0066 0.0073
Trypanosoma cruzi hypothetical protein 0.0066 0.0066 0.4829
Echinococcus multilocularis Oxysterol binding protein 11 0.0066 0.0066 0.0073
Brugia malayi TBC domain containing protein 0.0066 0.0066 0.0061
Echinococcus granulosus tyrosine protein kinase Fyn 0.0049 0.0028 0.0028
Brugia malayi plexin A 0.0937 0.2052 0.2049
Loa Loa (eye worm) hypothetical protein 0.0066 0.0066 0.0066
Loa Loa (eye worm) RGS-3 protein 0.0717 0.1551 0.1551
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0147 0.0251 0.1491
Schistosoma mansoni tyrosine kinase 0.0049 0.0028 0.0015
Entamoeba histolytica PH domain containing protein kinase, putative 0.0084 0.0106 0.0514
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0028 0.0015
Loa Loa (eye worm) TK/CSK protein kinase 0.0049 0.0028 0.0028
Leishmania major hypothetical protein, conserved 0.0066 0.0066 0.4829
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0049 0.0028 0.0031
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0049 0.0028 0.0028
Schistosoma mansoni cell adhesion molecule 0.0085 0.011 0.0097
Brugia malayi Protein kinase domain containing protein 0.0049 0.0028 0.0023
Echinococcus granulosus myotubularin protein 13 0.0066 0.0066 0.0073
Echinococcus multilocularis protein KINase family member (kin 25) 0.0049 0.0028 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0066 0.0278
Schistosoma mansoni fibrocystin l 0.0147 0.0251 0.0238
Echinococcus multilocularis tyrosine protein kinase Srms 0.0049 0.0028 0.0028
Schistosoma mansoni hypothetical protein 0.0066 0.0066 0.0053
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0049 0.0028 0.0028
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Brugia malayi Regulator of G protein signaling domain containing protein 0.0717 0.1551 0.1547
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0049 0.0028 0.0028
Entamoeba histolytica hypothetical protein 0.0717 0.1551 1
Echinococcus multilocularis chromobox protein 1 0.0084 0.0108 0.0123
Trichomonas vaginalis guanyl-nucleotide exchange factor, putative 0.0066 0.0066 0.0278
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0049 0.0028 0.0023
Echinococcus granulosus tyrosine protein kinase shark 0.0049 0.0028 0.0028
Schistosoma mansoni protein kinase 0.0077 0.0092 0.0079
Onchocerca volvulus 0.0049 0.0028 0.0163
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0084 0.0106 1
Brugia malayi Protein kinase domain containing protein 0.0049 0.0028 0.0023
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.339 0.7646 0.7646
Loa Loa (eye worm) hypothetical protein 0.0336 0.0681 0.0681
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0106 0.0543
Schistosoma mansoni hypothetical protein 0.0454 0.0952 0.094
Echinococcus granulosus pdz domain containing protein 0.0066 0.0066 0.0073
Echinococcus granulosus regulator of G protein signaling 7 0.0717 0.1551 0.1849
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Echinococcus granulosus tyrosine protein kinase Srms 0.0049 0.0028 0.0028
Echinococcus multilocularis polycomb protein SCMH1 0.0058 0.0047 0.0051
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0066 0.0066 0.0248
Schistosoma mansoni axis inhibition protein axin 0.0717 0.1551 0.154
Loa Loa (eye worm) hypothetical protein 0.0049 0.0028 0.0028
Echinococcus granulosus Pleckstrin domain containing protein family B 0.0066 0.0066 0.0073
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Echinococcus granulosus semaphorin 1A 0.0336 0.0681 0.0809
Schistosoma mansoni phosphoinositol 4-phosphate adaptor protein 0.0066 0.0066 0.0053
Echinococcus granulosus dynamin 1 0.0066 0.0066 0.0073
Brugia malayi Protein kinase domain containing protein 0.0049 0.0028 0.0023
Entamoeba histolytica pleckstrin homology (PH) domain containing protein 0.0066 0.0066 0.0248
Loa Loa (eye worm) mbt repeat family protein 0.0058 0.0047 0.0047
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0106 0.0543
Echinococcus multilocularis hypothetical protein 0.0336 0.0681 0.0809
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0066 0.0066 0.0248
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0717 0.1551 0.154
Loa Loa (eye worm) hypothetical protein 0.0717 0.1551 0.1551
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0049 0.0028 0.0028
Entamoeba histolytica p21-activated kinase 0.0084 0.0106 0.0514
Echinococcus granulosus histone acetyltransferase MYST2 0.0066 0.0065 0.0072
Echinococcus multilocularis FL cytokine receptor 0.0049 0.0028 0.0028
Entamoeba histolytica hypothetical protein 0.0066 0.0066 0.0248
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0147 0.0251 0.1491
Echinococcus multilocularis tyrosine protein kinase pr2 0.0049 0.0028 0.0028
Trypanosoma brucei protein kinase, putative 0.0067 0.0068 0.5171
Brugia malayi Protein kinase domain containing protein 0.0049 0.0028 0.0023
Schistosoma mansoni tyrosine protein kinase 0.0049 0.0028 0.0015
Loa Loa (eye worm) plexin A 0.0937 0.2052 0.2052
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0106 0.0543
Trypanosoma cruzi NIMA-related kinase, putative 0.0084 0.0106 1
Echinococcus multilocularis GRB2 associated binding protein 3 0.0066 0.0066 0.0073
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0106 0.0543
Echinococcus granulosus tyrosine protein kinase pr2 0.0049 0.0028 0.0028
Toxoplasma gondii hypothetical protein 0.0066 0.0066 0.4829
Entamoeba histolytica hypothetical protein 0.0717 0.1551 1
Echinococcus granulosus tyrosine protein kinase csk 0.0049 0.0028 0.0028
Plasmodium falciparum phosphatidylinositol transfer protein, putative 0.0066 0.0066 0.4829
Echinococcus granulosus beta-adrenergic receptor kinase 0.339 0.7646 0.9139
Brugia malayi hypothetical protein 0.0066 0.0066 0.0061
Echinococcus granulosus oxysterol binding protein 9 0.0066 0.0066 0.0073
Loa Loa (eye worm) RhoGEF domain-containing protein 0.0066 0.0066 0.0066
Leishmania major folate/biopterin transporter, putative 0.0084 0.0106 1
Echinococcus granulosus activin receptor type 0.0067 0.0068 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.0147 0.0251 0.1491
Schistosoma mansoni hypothetical protein 0.0336 0.0681 0.0669
Plasmodium falciparum serine/threonine protein kinase, putative 0.0077 0.0092 0.8137
Schistosoma mansoni protein kinase 0.0049 0.0028 0.0015
Schistosoma mansoni tyrosine kinase 0.0049 0.0028 0.0015
Entamoeba histolytica hypothetical protein 0.0717 0.1551 1
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Brugia malayi Immunoglobulin I-set domain containing protein 0.013 0.0211 0.0207
Brugia malayi Protein kinase domain containing protein 0.0049 0.0028 0.0023
Brugia malayi PH domain containing protein 0.0066 0.0066 0.0061
Entamoeba histolytica protein kinase, putative 0.0084 0.0106 0.0514
Brugia malayi Protein kinase domain containing protein 0.0049 0.0028 0.0023
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Echinococcus multilocularis receptor type guanylyl cyclase 0.0049 0.0028 0.0028
Echinococcus granulosus GRB2 associated binding protein 3 0.0066 0.0066 0.0073
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0084 0.0106 1
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0049 0.0028 0.0023
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0084 0.0106 1
Loa Loa (eye worm) TK protein kinase 0.0049 0.0028 0.0028
Onchocerca volvulus 0.079 0.1717 1
Schistosoma mansoni rho gtpase activating protein 0.0066 0.0066 0.0053
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0077 0.0092 0.0418
Loa Loa (eye worm) TK/INSR protein kinase 0.0049 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0049 0.0028 0.0028
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0717 0.1551 0.154
Echinococcus granulosus oxysterol binding protein 3 0.0066 0.0066 0.0073
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0049 0.0028 0.0028
Echinococcus granulosus tyrosine kinase 0.0049 0.0028 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0066 0.0278
Trichomonas vaginalis kinesin light chain, putative 0.0066 0.0066 0.0278
Brugia malayi Sema domain containing protein 0.0336 0.0681 0.0677
Onchocerca volvulus 0.0049 0.0028 0.0163
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0717 0.1551 1
Echinococcus granulosus ephrin type A receptor 4 A 0.0049 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0049 0.0028 0.0028
Echinococcus multilocularis integrin linked protein kinase 0.0049 0.0028 0.0028
Echinococcus granulosus regulator of G protein signaling 3 0.0717 0.1551 0.1849
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0084 0.0106 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.0066 0.0066
Onchocerca volvulus 0.0066 0.0066 0.0383
Brugia malayi Plekhf2 protein 0.0066 0.0066 0.0061
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0066 0.0066 0.0278
Brugia malayi SH2 domain containing protein 0.0049 0.0028 0.0023
Schistosoma mansoni goodpasture antigen-binding protein 0.0066 0.0066 0.0053
Schistosoma mansoni tyrosine kinase 0.0049 0.0028 0.0015
Echinococcus granulosus Oxysterol binding protein 11 0.0066 0.0066 0.0073
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0049 0.0028 0.0028
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0049 0.0028 0.0028
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0049 0.0028 0.0023
Echinococcus granulosus activated cdc42 kinase 1 0.0049 0.0028 0.0028
Brugia malayi DNA-binding protein LAG-1 0.0147 0.0251 0.0246
Brugia malayi Protein kinase domain containing protein 0.0049 0.0028 0.0023
Brugia malayi Heterochromatin protein 1 0.0084 0.0108 0.0103
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0084 0.0106 0.0543
Echinococcus granulosus axis inhibition protein axin 0.0717 0.1551 0.1849
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0066 0.0278
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0049 0.0028 0.0028
Loa Loa (eye worm) TK protein kinase 0.0049 0.0028 0.0028
Entamoeba histolytica PH domain containing protein kinase, putative 0.0084 0.0106 0.0514
Loa Loa (eye worm) hypothetical protein 0.0049 0.0028 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0028 0.0031
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0147 0.0251 0.1491
Schistosoma mansoni protein kinase 0.0049 0.0028 0.0015
Echinococcus granulosus roundabout 2 0.0085 0.011 0.0126
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0049 0.0028 0.0028
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Echinococcus granulosus tyrosine protein kinase Fyn 0.0049 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0047 0.0023 0.0023
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0049 0.0028 0.0028
Echinococcus multilocularis axis inhibition protein axin 0.0717 0.1551 0.1849
Loa Loa (eye worm) hypothetical protein 0.0066 0.0066 0.0066
Schistosoma mansoni tyrosine kinase 0.0049 0.0028 0.0015
Echinococcus multilocularis Pleckstrin y 0.0066 0.0066 0.0073
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0028 0.0015
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0084 0.0106 1
Brugia malayi Protein kinase domain containing protein 0.0049 0.0028 0.0023
Loa Loa (eye worm) TK/RYK protein kinase 0.0049 0.0028 0.0028
Echinococcus granulosus arf GAP with coiled coil ANK repeat and PH 0.0066 0.0066 0.0073
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0106 0.0543
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0049 0.0028 0.0028
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0028 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0717 0.1551 1
Loa Loa (eye worm) hypothetical protein 0.0147 0.0251 0.0251
Echinococcus multilocularis roundabout 2 0.0085 0.011 0.0126
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Trichomonas vaginalis ankyrin repeat and FYVE domain containing protein, putative 0.0066 0.0066 0.0278
Plasmodium falciparum PH domain-containing protein, putative 0.0066 0.0066 0.4829
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0106 0.0543
Trichomonas vaginalis AGC family protein kinase 0.0077 0.0092 0.0447
Entamoeba histolytica PH domain containing protein 0.0066 0.0066 0.0248
Echinococcus multilocularis regulator of G protein signaling 3 0.0717 0.1551 0.1849
Schistosoma mansoni protein kinase 0.0067 0.0068 0.0056
Echinococcus granulosus tyrosine protein kinase Src42A 0.0049 0.0028 0.0028
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0066 0.0066 0.0061
Loa Loa (eye worm) TK/Met protein kinase 0.0049 0.0028 0.0028
Loa Loa (eye worm) serine/threonine protein kinase 0.0049 0.0028 0.0028
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0049 0.0028 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0066 0.0278
Schistosoma mansoni tyrosine kinase 0.0049 0.0028 0.0015
Loa Loa (eye worm) hypothetical protein 0.0336 0.0681 0.0681
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Loa Loa (eye worm) hypothetical protein 0.008 0.0099 0.0099
Onchocerca volvulus 0.0049 0.0028 0.0163
Schistosoma mansoni hypothetical protein 0.0336 0.0681 0.0669
Echinococcus granulosus tyrosine protein kinase HCK 0.0049 0.0028 0.0028
Onchocerca volvulus Putative zinc finger protein 0.0066 0.0066 0.0383
Schistosoma mansoni protein kinase 0.0067 0.0068 0.0056
Brugia malayi PH domain containing protein 0.0066 0.0066 0.0061
Brugia malayi Protein kinase domain containing protein 0.0049 0.0028 0.0023
Entamoeba histolytica protein kinase, putative 0.0084 0.0106 0.0514
Brugia malayi Cadps2 protein 0.0066 0.0066 0.0061
Loa Loa (eye worm) hypothetical protein 0.0717 0.1551 0.1551
Echinococcus multilocularis axis inhibition protein axin 0.0717 0.1551 0.1849
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0049 0.0028 0.0028
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0077 0.0092 0.0104
Onchocerca volvulus Huntingtin homolog 0.0148 0.0253 0.1474
Entamoeba histolytica hypothetical protein 0.0084 0.0106 0.0514
Schistosoma mansoni plexin 0.079 0.1717 0.1706
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0066 0.0066 0.0248
Echinococcus granulosus Pleckstrin y 0.0066 0.0066 0.0073
Echinococcus multilocularis beta 1 syntrophin 0.0066 0.0066 0.0073
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.008 0.0099 0.0086
Loa Loa (eye worm) hypothetical protein 0.0147 0.0251 0.0251
Echinococcus multilocularis activated cdc42 kinase 1 0.0049 0.0028 0.0028
Onchocerca volvulus 0.0066 0.0066 0.0383
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0049 0.0028 0.0163
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Trypanosoma cruzi hypothetical protein 0.0066 0.0066 0.4829
Echinococcus multilocularis SAM and MBT domain containing protein 0.0058 0.0047 0.0051
Echinococcus multilocularis G protein coupled receptor kinase 6 0.3706 0.8365 1
Schistosoma mansoni tyrosine kinase 0.0049 0.0028 0.0015
Brugia malayi PXA domain containing protein 0.0717 0.1551 0.1547
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0106 0.0543
Onchocerca volvulus 0.0049 0.0028 0.0163
Toxoplasma gondii phosphatidylinositol transfer protein 0.0066 0.0066 0.4829
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0028 0.0031
Schistosoma mansoni tyrosine kinase 0.0049 0.0028 0.0015
Echinococcus granulosus plexin a4 0.0937 0.2052 0.2449
Entamoeba histolytica protein kinase, putative 0.0084 0.0106 0.0514
Loa Loa (eye worm) hypothetical protein 0.0147 0.0251 0.0251
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Loa Loa (eye worm) sema domain-containing protein 0.0336 0.0681 0.0681
Brugia malayi Protein kinase domain containing protein 0.0049 0.0028 0.0023
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0066 0.0066 0.0248
Echinococcus multilocularis Arf GAP and Pleckstrin domain containing protein 0.0066 0.0066 0.0073
Loa Loa (eye worm) hypothetical protein 0.0049 0.0028 0.0028
Trypanosoma brucei protein kinase, putative 0.0084 0.0106 1
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Echinococcus granulosus fibroblast growth factor receptor 4 0.0049 0.0028 0.0028
Loa Loa (eye worm) PH domain-containing protein 0.0066 0.0066 0.0066
Echinococcus multilocularis c src tyrosine kinase 0.0049 0.0028 0.0028
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0049 0.0028 0.0015
Brugia malayi Protein kinase domain containing protein 0.0049 0.0028 0.0023
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0049 0.0028 0.0028
Echinococcus granulosus twitchin 0.0098 0.0139 0.0161
Loa Loa (eye worm) hypothetical protein 0.0066 0.0066 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0066 0.0278
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0066 0.0278
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0067 0.0068 0.0076
Onchocerca volvulus 0.0049 0.0028 0.0163
Schistosoma mansoni nephrin 0.0085 0.011 0.0097
Loa Loa (eye worm) MBCTL1 0.0066 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.008 0.0099 0.0099
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0049 0.0028 0.0028
Echinococcus multilocularis type II inositol 3,4 bisphosphate 4 phosphatase 0.0066 0.0066 0.0073
Echinococcus multilocularis pleckstrin y domain containing family A 0.0066 0.0066 0.0073
Loa Loa (eye worm) hypothetical protein 0.0066 0.0066 0.0066
Echinococcus granulosus expressed protein 0.0717 0.1551 0.1849
Echinococcus multilocularis natriuretic peptide receptor 1 0.0049 0.0028 0.0028
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0054 0.0039 0.0041
Schistosoma mansoni regulator of G protein signaling 0.0717 0.1551 0.154
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0066 0.0066 0.4829
Echinococcus multilocularis G protein coupled receptor kinase 1 0.2673 0.601 0.7184
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0049 0.0028 0.0031
Echinococcus granulosus raf serine:threonine protein kinase 0.0049 0.0028 0.0028
Brugia malayi Regulator of G protein signaling domain containing protein 0.0717 0.1551 0.1547
Loa Loa (eye worm) hypothetical protein 0.0148 0.0253 0.0253
Echinococcus granulosus kinase suppressor of Ras 1 0.0049 0.0028 0.0028
Schistosoma mansoni tyrosine kinase 0.0049 0.0028 0.0015
Schistosoma mansoni tyrosine kinase 0.0049 0.0028 0.0015
Echinococcus multilocularis cytohesin 1 0.0066 0.0066 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0028 0.0031
Brugia malayi Cytohesin 3 0.0066 0.0066 0.0061
Loa Loa (eye worm) hypothetical protein 0.0066 0.0066 0.0066
Trypanosoma cruzi ADP-ribosylation factor family, putative 0.0066 0.0066 0.4829
Loa Loa (eye worm) rho-GTPase-activating 0.0066 0.0066 0.0066
Echinococcus multilocularis raf serine:threonine protein kinase 0.0049 0.0028 0.0028
Schistosoma mansoni serine/threonine-protein kinase 0.0084 0.0106 0.0093
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0028 0.0028
Echinococcus granulosus protein tyrosine kinase 0.0049 0.0028 0.0028
Echinococcus multilocularis insulin receptor 0.0049 0.0028 0.0028
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0028 0.0031
Schistosoma mansoni zinc finger protein 0.0066 0.0066 0.0053
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0106 0.0543
Loa Loa (eye worm) AUR protein kinase 0.0077 0.0092 0.0092
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0147 0.0251 0.1491
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Schistosoma mansoni hypothetical protein 0.0066 0.0066 0.0053
Echinococcus granulosus tyrosine kinase 0.0049 0.0028 0.0028
Plasmodium vivax oxysterol-binding protein/PH domain containing protein 0.0066 0.0066 0.4829
Schistosoma mansoni tyrosine kinase 0.0049 0.0028 0.0015
Echinococcus granulosus chromobox protein 1 0.0084 0.0108 0.0123
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0028 0.0028
Schistosoma mansoni tyrosine kinase 0.0049 0.0028 0.0015
Loa Loa (eye worm) TK protein kinase 0.0049 0.0028 0.0028
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0067 0.0068 0.0076
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Trypanosoma cruzi hypothetical protein 0.0066 0.0066 0.4829
Echinococcus granulosus aurora kinase A 0.0077 0.0092 0.0104
Echinococcus granulosus pleckstrin y domain containing family A 0.0066 0.0066 0.0073
Schistosoma mansoni chromobox protein 0.0084 0.0108 0.0095
Echinococcus multilocularis oxysterol binding protein 1 0.0066 0.0066 0.0073
Trichomonas vaginalis centaurin/arf, putative 0.0066 0.0066 0.0278
Trichomonas vaginalis conserved hypothetical protein 0.0717 0.1551 1
Onchocerca volvulus 0.0049 0.0028 0.0163
Trichomonas vaginalis AGC family protein kinase 0.0084 0.0106 0.0543
Loa Loa (eye worm) hypothetical protein 0.0066 0.0066 0.0066
Plasmodium falciparum protein kinase, putative 0.0067 0.0068 0.5171
Loa Loa (eye worm) hypothetical protein 0.0231 0.0443 0.0443
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0049 0.0028 0.0028
Onchocerca volvulus 0.0066 0.0066 0.0383
Schistosoma mansoni regulator of G protein signaling 0.0717 0.1551 0.154
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0049 0.0028 0.0028
Brugia malayi Probable exocyst complex component Sec5 0.0147 0.0251 0.0246
Echinococcus multilocularis Pleckstrin y 0.0066 0.0066 0.0073
Echinococcus multilocularis semaphorin 5B 0.0336 0.0681 0.0809
Brugia malayi Protein kinase domain containing protein 0.0049 0.0028 0.0023
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.3706 0.8365 0.8365
Trichomonas vaginalis protein tyrosine kinase, putative 0.0049 0.0028 0.0031
Trichomonas vaginalis alpha chimerin, putative 0.0066 0.0066 0.0278
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Trypanosoma cruzi hypothetical protein 0.0066 0.0066 0.4829
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0028 0.0031
Entamoeba histolytica hypothetical protein 0.0066 0.0066 0.0248
Loa Loa (eye worm) SRC-1 0.0049 0.0028 0.0028
Loa Loa (eye worm) cytohesin 3 0.0066 0.0066 0.0066
Trichomonas vaginalis TKL family protein kinase 0.0049 0.0028 0.0031
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0028 0.0028
Echinococcus granulosus Arf GAP and Pleckstrin domain containing protein 0.0066 0.0066 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0066 0.0278
Echinococcus multilocularis chromobox protein 1 0.0084 0.0108 0.0123
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0066 0.0066 0.4829
Echinococcus granulosus protein kinase 0.0049 0.0028 0.0028

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.1 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 0.3162 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) = 0.5012 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 3.2944 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.