Detailed information for compound 1448988

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 348.395 | Formula: C21H20N2O3
  • H donors: 1 H acceptors: 3 LogP: 4.34 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)c1cncnc1c1ccc(cc1O)OCC(=C)C
  • InChi: 1S/C21H20N2O3/c1-14(2)12-26-17-8-9-18(20(24)10-17)21-19(11-22-13-23-21)15-4-6-16(25-3)7-5-15/h4-11,13,24H,1,12H2,2-3H3
  • InChiKey: ZQDKQNDRQMPANH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0086 0.0536
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0029 0.0012 0.0043
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0074 0.0146 0.0146
Echinococcus granulosus caspase 0.0027 0.0006 0.0006
Echinococcus granulosus transcription factor Dp 1 0.0079 0.016 0.016
Leishmania major DNA polymerase kappa, putative 0.0122 0.0287 0.1046
Trypanosoma brucei metacaspase 0.0027 0.0006 0.0024
Leishmania major phosphoglycerate kinase B, cytosolic 0.0352 0.0971 0.3541
Schistosoma mansoni caspase-3 (C14 family) 0.0027 0.0006 0.0006
Trypanosoma brucei metacaspase 5, putative 0.0027 0.0006 0.0024
Loa Loa (eye worm) hypothetical protein 0.0202 0.0526 0.1987
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0029 0.0012 0.0045
Trypanosoma brucei Sphingosine kinase 0.0036 0.0032 0.0116
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.009 0.056
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0948 0.2743 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0272 0.0735 0.2777
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0036 0.0032 0.0032
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0084 0.0522
Echinococcus multilocularis bloom syndrome protein 0.0094 0.0204 0.0204
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0012 0.0078
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0352 0.0971 0.3668
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0031 0.0115
Brugia malayi beta-lactamase 0.0038 0.0037 0.0233
Loa Loa (eye worm) hypothetical protein 0.0067 0.0123 0.0466
Trichomonas vaginalis helicase, putative 0.0054 0.0086 0.0536
Echinococcus multilocularis cpg binding protein 0.029 0.0787 0.0787
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0032 0.0021 0.0131
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0037 0.0233
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0021 0.0021
Trypanosoma brucei DNA polymerase kappa, putative 0.0086 0.0181 0.066
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0086 0.0183 0.1882
Loa Loa (eye worm) hypothetical protein 0.0039 0.0041 0.0154
Toxoplasma gondii exonuclease III APE 0.008 0.0164 0.1275
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0099 0.0221 0.0831
Trypanosoma brucei DNA polymerase kappa, putative 0.0142 0.0349 0.1272
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0032 0.0021 0.0131
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0133 0.0322 0.1174
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0000025507 0.00000000029541
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0027 0.0006 0.004
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0114 0.0415
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.009 0.009
Onchocerca volvulus 0.0029 0.0012 0.0089
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0029 0.0012 0.0045
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.009 0.034
Treponema pallidum phosphoglycerate kinase 0.0352 0.0971 1
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.017 0.043 0.043
Entamoeba histolytica hypothetical protein 0.0148 0.0366 0.1377
Brugia malayi Bloom's syndrome protein homolog 0.0094 0.0204 0.1273
Trypanosoma brucei DNA polymerase IV, putative 0.0142 0.0349 0.1272
Loa Loa (eye worm) hypothetical protein 0.003 0.0014 0.0055
Mycobacterium ulcerans hypothetical protein 0.0038 0.0037 0.0137
Brugia malayi diacylglycerol kinase 0.0036 0.0032 0.0198
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0032 0.0198
Trichomonas vaginalis DNA helicase recq1, putative 0.0094 0.0204 0.1273
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0352 0.0971 0.6051
Trypanosoma brucei phosphoglycerate kinase 0.0129 0.031 0.1128
Loa Loa (eye worm) hypothetical protein 0.0063 0.0114 0.043
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0012 0.0043
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0086 0.0183 0.1872
Loa Loa (eye worm) hypothetical protein 0.0074 0.0146 0.0553
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0099 0.0221 0.2267
Loa Loa (eye worm) hypothetical protein 0.0916 0.2647 1
Loa Loa (eye worm) hypothetical protein 0.0025 0 0.0001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0032 0.0021 0.0079
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0202 0.0526 0.3277
Echinococcus multilocularis intestinal type alkaline phosphatase 0.017 0.043 0.043
Trichomonas vaginalis dullard protein, putative 0.0025 0.0001 0.0007
Brugia malayi Mitochondrial import inner membrane translocase subunit TIM10 0.0047 0.0066 0.0409
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0021 0.0131
Trypanosoma brucei DNA polymerase kappa, putative 0.0086 0.0181 0.066
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0115 0.0266 0.1006
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0045 0.0045
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0025 0.0001 0.0003
Echinococcus multilocularis ferritin 0.0025 0.0001 0.0001
Trichomonas vaginalis ferritin, putative 0.0025 0.0001 0.0007
Loa Loa (eye worm) glutaminase 2 0.0565 0.1605 0.6064
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.009 0.009
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0136 0.0331 0.1208
Entamoeba histolytica acyl-CoA synthetase, putative 0.0099 0.0221 0.0831
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0012 0.0116
Mycobacterium ulcerans hypothetical protein 0.0499 0.141 0.5324
Chlamydia trachomatis phosphoglycerate kinase 0.0352 0.0971 1
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.017 0.043 0.043
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0025 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0285 0.0773 0.2919
Schistosoma mansoni RAR-like nuclear receptor 0.0032 0.0021 0.0021
Echinococcus granulosus FTZ F1 alpha 0.0032 0.0021 0.0021
Schistosoma mansoni transcription factor LCR-F1 0.0148 0.0366 0.0366
Loa Loa (eye worm) steroid hormone receptor 0.0032 0.0021 0.0079
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0129 0.031 0.1128
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0032 0.0021 0.0021
Brugia malayi PHD-finger family protein 0.0065 0.0119 0.0742
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0037 0.014
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0136 0.0331 0.1208
Plasmodium vivax acetyl-CoA synthetase, putative 0.0029 0.0012 0.0128
Loa Loa (eye worm) hypothetical protein 0.0027 0.0006 0.0025
Echinococcus granulosus microtubule associated protein 2 0.0728 0.2089 0.2089
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0037 0.0233
Echinococcus granulosus mixed lineage leukemia protein mll 0.0061 0.0108 0.0108
Echinococcus multilocularis lysine specific demethylase 5A 0.0094 0.0204 0.0204
Schistosoma mansoni zinc finger protein 0.0032 0.002 0.002
Brugia malayi Bromodomain containing protein 0.0035 0.0029 0.0181
Schistosoma mansoni hypothetical protein 0.0138 0.0336 0.0336
Onchocerca volvulus 0.0038 0.0037 0.0268
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0084 0.0084
Trypanosoma brucei DNA polymerase kappa, putative 0.0142 0.0349 0.1272
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0037 0.014
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0057 0.0094 0.0354
Schistosoma mansoni blooms syndrome DNA helicase 0.0074 0.0146 0.0146
Trichomonas vaginalis ap endonuclease, putative 0.008 0.0164 0.1022
Loa Loa (eye worm) hypothetical protein 0.0032 0.0021 0.0079
Schistosoma mansoni cpg binding protein 0.0272 0.0735 0.0735
Trypanosoma brucei unspecified product 0.0079 0.0161 0.0586
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0032 0.0021 0.0021
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0064 0.0116 0.0116
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0054 0.0086 0.0536
Entamoeba histolytica hypothetical protein 0.0148 0.0366 0.1377
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0037 0.014
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0086 0.0183 0.044
Schistosoma mansoni cpg binding protein 0.029 0.0787 0.0787
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.017 0.043 0.043
Loa Loa (eye worm) ceramide kinase 0.0036 0.0032 0.012
Mycobacterium ulcerans acyl-CoA synthetase 0.0099 0.0221 0.0831
Loa Loa (eye worm) hypothetical protein 0.0039 0.0043 0.0162
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.008 0.0164 0.168
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0029 0.0012 0.0097
Echinococcus granulosus acylglycerol kinase mitochondrial 0.0036 0.0032 0.0032
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0037 0.0136
Echinococcus multilocularis ecdysone induced protein 78C 0.0032 0.0021 0.0021
Entamoeba histolytica recQ family helicase, putative 0.005 0.0075 0.0277
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0064 0.0116 0.0721
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.009 0.009
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0352 0.0971 0.7546
Leishmania major sphingosine kinase A, B, putative 0.0036 0.0032 0.0116
Echinococcus multilocularis sphingosine kinase 1 0.0916 0.2647 0.2647
Echinococcus granulosus expressed protein 0.0025 0.0001 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0142 0.0349 0.1272
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0025 0.0001 0.0009
Loa Loa (eye worm) hypothetical protein 0.0025 0.0001 0.0005
Schistosoma mansoni alkaline phosphatase 0.017 0.043 0.043
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0039 0.0041 0.0041
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0029 0.0012 0.0012
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0021 0.0021
Echinococcus multilocularis dna polymerase kappa 0.0142 0.0349 0.0349
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0032 0.0021 0.0021
Echinococcus multilocularis 0.0025 0.0001 0.0001
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0065 0.0065
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0012 0.0046
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0085 0.0178 0.1112
Loa Loa (eye worm) hypothetical protein 0.0352 0.0971 0.3669
Loa Loa (eye worm) hypothetical protein 0.0053 0.0084 0.0316
Brugia malayi Ceramide kinase 0.0036 0.0032 0.0198
Brugia malayi polk-prov protein 0.0063 0.0114 0.071
Echinococcus granulosus fetal alzheimer antigen falz 0.006 0.0105 0.0105
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0045 0.0277
Mycobacterium ulcerans hypothetical protein 0.0916 0.2647 1
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0029 0.0012 0.0043
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.008 0.0164 0.0616
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0129 0.031 0.1128
Loa Loa (eye worm) hypothetical protein 0.0032 0.0021 0.0079
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0014 0.0112
Schistosoma mansoni zinc finger protein 0.0054 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0038 0.0037 0.0141
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0071 0.0137 0.0137
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0012 0.0043
Onchocerca volvulus 0.0029 0.0012 0.0089
Giardia lamblia PHD finger protein 15 0.003 0.0014 0.0136
Loa Loa (eye worm) PHD-finger family protein 0.0043 0.0053 0.0198
Trypanosoma brucei chrX additional, unordered contigs 0.0036 0.0031 0.0115
Brugia malayi AMP-binding enzyme family protein 0.0099 0.0221 0.1378
Schistosoma mansoni hypothetical protein 0.0064 0.0116 0.0116
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0037 0.0037
Echinococcus granulosus expressed protein 0.0035 0.0029 0.0029
Onchocerca volvulus 0.0029 0.0012 0.0089
Echinococcus granulosus peregrin 0.0035 0.0029 0.0029
Mycobacterium ulcerans hypothetical protein 0.0099 0.0221 0.0831
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0102 0.0229 0.0229
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0111 0.0111
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0031 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0086 0.0536
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0076 0.0151 0.0151
Plasmodium vivax diacylglycerol kinase, putative 0.0036 0.0032 0.0327
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0085 0.0178 0.0178
Loa Loa (eye worm) hypothetical protein 0.0084 0.0176 0.0665
Leishmania major DNA polymerase eta, putative 0.0114 0.0265 0.0967
Brugia malayi nuclear hormone receptor 0.0032 0.0021 0.0131
Trypanosoma brucei Metacaspase-4 0.0027 0.0006 0.0024
Trichomonas vaginalis rotamase, putative 0.0035 0.0029 0.0183
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0025 0.0001 0.0007
Trichomonas vaginalis dullard protein, putative 0.0025 0.0001 0.0007
Mycobacterium tuberculosis Conserved protein 0.0038 0.0037 0.014
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0021 0.0021
Trichomonas vaginalis set domain proteins, putative 0.0495 0.1396 0.87
Brugia malayi mbt repeat family protein 0.0047 0.0065 0.0402
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0029 0.0012 0.0116
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0039 0.0041 0.0316
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0006 0.004
Schistosoma mansoni sphingoid long chain base kinase 0.0916 0.2647 0.2647
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0037 0.014
Loa Loa (eye worm) hypothetical protein 0.0085 0.0178 0.0674
Schistosoma mansoni hypothetical protein 0.004 0.0045 0.0045
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0045 0.0277
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.007 0.0134 0.0506
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0025 0.0001 0.0003
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.004 0.0045 0.0168
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0054 0.0086 0.0536
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0111 0.0111
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0102 0.0102
Leishmania major 4-coumarate:coa ligase-like protein 0.0099 0.0221 0.0806
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0032 0.0021 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0012 0.0073
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0084 0.0084
Brugia malayi beta-lactamase family protein 0.0038 0.0037 0.0233
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0025 0.0001 0.0008
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0067 0.0125 0.0125
Schistosoma mansoni peptidase Clp (S14 family) 0.0086 0.0183 0.0183
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0029 0.0012 0.0047
Schistosoma mansoni ferritin 0.0025 0.0001 0.0001
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0029 0.0012 0.0045
Echinococcus granulosus alkaline phosphatase 0.017 0.043 0.043
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0111 0.0111
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0029 0.0183
Onchocerca volvulus 0.0038 0.0037 0.0268
Brugia malayi CXXC zinc finger family protein 0.0272 0.0735 0.458
Giardia lamblia Sgs1 DNA helicase, putative 0.0039 0.0041 0.0407
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0029 0.0012 0.0043
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0039 0.0041 0.0254
Loa Loa (eye worm) hypothetical protein 0.0032 0.0021 0.0079
Trypanosoma brucei DNA polymerase kappa, putative 0.0142 0.0349 0.1272
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0352 0.0971 1
Onchocerca volvulus Bile acid receptor homolog 0.0032 0.0021 0.015
Trypanosoma cruzi metacaspase, putative 0.0027 0.0006 0.0024
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0012 0.0078
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0064 0.0116 0.0116
Plasmodium falciparum DNA repair protein REV1, putative 0.0036 0.0031 0.0324
Schistosoma mansoni myst-related protein 0.0032 0.0021 0.0021
Echinococcus granulosus tumor protein p63 0.0362 0.1002 0.1002
Trichomonas vaginalis diacylglycerol kinase, epsilon, putative 0.0036 0.0032 0.0198
Brugia malayi Phosphoglycerate kinase 0.0352 0.0971 0.6051
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0083 0.0083
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0025 0.0001 0.0001
Trypanosoma cruzi Diacylglycerol kinase catalytic domain containing protein, putative 0.0036 0.0032 0.0116
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.008 0.0164 0.1679
Schistosoma mansoni DNA polymerase IV / kappa 0.0036 0.0031 0.0031
Echinococcus granulosus L aminoadipate semialdehyde 0.0085 0.0178 0.0178
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0006 0.004
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0086 0.0183 0.142
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0029 0.0012 0.0078
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0136 0.0331 0.0331
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0029 0.0012 0.0078
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0032 0.0021 0.0021
Giardia lamblia DNA damage repair protein 0.0036 0.0031 0.0312
Loa Loa (eye worm) hypothetical protein 0.0027 0.0007 0.0026
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0037 0.0233
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0065 0.0065
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0061 0.0108 0.0108
Schistosoma mansoni microtubule-associated protein tau 0.0728 0.2089 0.2089
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0036 0.0032 0.0198
Echinococcus multilocularis FTZ F1 alpha 0.0032 0.0021 0.0021
Echinococcus multilocularis tumor protein p63 0.0362 0.1002 0.1002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0032 0.0021 0.0079
Schistosoma mansoni mitochondrial import inner membrane translocase subunit tim10 0.0047 0.0066 0.0066
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0036 0.0032 0.0198
Brugia malayi Probable ClpP-like protease 0.0086 0.0183 0.1139
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0032 0.0021 0.0131
Plasmodium falciparum acyl-CoA synthetase 0.0074 0.0146 0.1508
Entamoeba histolytica acyl-coA synthetase, putative 0.0099 0.0221 0.0831
Schistosoma mansoni hypothetical protein 0.339 1 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0032 0.0021 0.0021
Entamoeba histolytica hypothetical protein 0.0148 0.0366 0.1377
Loa Loa (eye worm) hypothetical protein 0.0032 0.0021 0.0079
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0029 0.0012 0.0128
Loa Loa (eye worm) hypothetical protein 0.0074 0.0146 0.0553
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.009 0.009
Echinococcus granulosus GPCR family 2 0.0064 0.0116 0.0116
Schistosoma mansoni apoferritin-2 0.0025 0.0001 0.0001
Onchocerca volvulus 0.0085 0.0178 0.1278
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0006 0.004
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM10, putative 0.0047 0.0066 0.0676
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0037 0.014
Loa Loa (eye worm) hypothetical protein 0.0074 0.0146 0.0553
Trypanosoma cruzi metacaspase, putative 0.0027 0.0006 0.0024
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0027 0.0006 0.005
Loa Loa (eye worm) hypothetical protein 0.0099 0.0221 0.0835
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0148 0.0366 0.0366
Trypanosoma cruzi Sphingosine kinase 0.0036 0.0032 0.0116
Trypanosoma brucei DNA damage repair protein, putative 0.0036 0.0031 0.0115
Mycobacterium ulcerans diacylglycerol kinase 0.0036 0.0032 0.0115
Loa Loa (eye worm) glutaminase 0.0565 0.1605 0.6064
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0115 0.0266 0.0266
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0027 0.0006 0.005
Trypanosoma brucei DNA polymerase kappa, putative 0.0122 0.0287 0.1046
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0012 0.0043
Mycobacterium ulcerans DNA polymerase IV 0.0142 0.0349 0.1314
Schistosoma mansoni hypothetical protein 0.0036 0.0032 0.0032
Plasmodium falciparum phosphoglycerate kinase 0.0352 0.0971 1
Trypanosoma cruzi ISWI complex protein 0.0025 0.0000025507 0.0000092979
Brugia malayi exodeoxyribonuclease III family protein 0.008 0.0164 0.1023
Brugia malayi mbt repeat family protein 0.0047 0.0065 0.0402
Echinococcus granulosus ferritin 0.0025 0.0001 0.0001
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0948 0.2743 1
Loa Loa (eye worm) diacylglycerol kinase 2 0.0036 0.0032 0.012
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0129 0.031 0.1128
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0086 0.0183 0.142
Brugia malayi hypothetical protein 0.0148 0.0366 0.2278
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0029 0.0012 0.0047
Trypanosoma brucei DNA polymerase kappa, putative 0.0142 0.0349 0.1272
Brugia malayi glutaminase DH11.1 0.0565 0.1605 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0037 0.0037
Onchocerca volvulus 0.0053 0.0083 0.0597
Entamoeba histolytica diacylglycerol kinase, putative 0.0036 0.0032 0.0115
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0025 0.0001 0.0012
Schistosoma mansoni SET domain protein 0.0025 0.0000016749 0.0000016749
Brugia malayi Steroid receptor seven-up type 2 0.0032 0.0021 0.0131
Trypanosoma cruzi metacaspase 5, putative 0.0027 0.0006 0.0024
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0032 0.0021 0.0021
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0037 0.0373
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0039 0.0041 0.0041
Schistosoma mansoni acetyl-CoA synthetase 0.0029 0.0012 0.0012
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.006 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0038 0.0037 0.0141
Schistosoma mansoni caspase-7 (C14 family) 0.0027 0.0006 0.0006
Loa Loa (eye worm) MBCTL1 0.0053 0.0084 0.0316
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0036 0.0031 0.0245
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0086 0.0183 0.1882
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.005 0.0075 0.0272
Leishmania major mitochondrial DNA polymerase beta 0.0948 0.2743 1
Trypanosoma brucei ISWI complex protein 0.0032 0.002 0.0072
Echinococcus multilocularis expressed protein 0.0025 0.0001 0.0001
Mycobacterium ulcerans DNA polymerase IV 0.0142 0.0349 0.1314
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0043 0.0052 0.0052
Plasmodium falciparum phd finger protein, putative 0.003 0.0014 0.0149
Toxoplasma gondii ABC1 family protein 0.0038 0.0037 0.0291
Schistosoma mansoni hypothetical protein 0.0064 0.0116 0.0116
Brugia malayi hypothetical protein 0.0036 0.0033 0.0206
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0086 0.0183 0.1872
Loa Loa (eye worm) hypothetical protein 0.0099 0.0221 0.0835
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0136 0.0331 0.1248
Mycobacterium ulcerans hypothetical protein 0.0036 0.0031 0.0115
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0074 0.0146 0.0552
Trypanosoma cruzi Sphingosine kinase 0.0036 0.0032 0.0116
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0049 0.0049
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0054 0.0086 0.0536
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0137 0.0333 0.0333
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0032 0.0021 0.0021
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0102 0.0229 0.0229
Echinococcus multilocularis GPCR, family 2 0.0064 0.0116 0.0116
Trypanosoma brucei metacaspase MCA3 0.0027 0.0006 0.0024
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.004 0.0045 0.0277
Trypanosoma cruzi diacylglycerol kinase, putative 0.0036 0.0032 0.0116
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0037 0.0137
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.008 0.0164 0.062
Onchocerca volvulus Ceramide kinase 1 homolog 0.0036 0.0032 0.0227
Echinococcus multilocularis transcription factor Dp 1 0.0079 0.016 0.016
Echinococcus granulosus bloom syndrome protein 0.0094 0.0204 0.0204
Trypanosoma cruzi DNA damage repair protein, putative 0.0036 0.0031 0.0115
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0086 0.0183 0.0183
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0029 0.0012 0.0046
Leishmania major diacylglycerol kinase-like protein 0.0036 0.0032 0.0116
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0032 0.0021 0.0021
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0014 0.0112
Trypanosoma brucei DNA polymerase IV, putative 0.0135 0.0328 0.1197
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0012 0.0046
Echinococcus granulosus ceramide kinase 0.0036 0.0032 0.0032
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0037 0.0233
Toxoplasma gondii peptidylprolyl isomerase 0.0034 0.0027 0.0209
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0012 0.0043
Echinococcus granulosus cpg binding protein 0.029 0.0787 0.0787
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.005 0.0075 0.0272
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0021 0.0021
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0057 0.0094 0.0959
Trypanosoma cruzi metacaspase, putative 0.0027 0.0006 0.0024
Schistosoma mansoni ferritin 0.0025 0.0001 0.0001
Loa Loa (eye worm) RecQ helicase 0.0094 0.0204 0.0772
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0006 0.004
Loa Loa (eye worm) hypothetical protein 0.0099 0.0221 0.0835
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0032 0.0021 0.0021
Entamoeba histolytica deoxycytidyl transferase, putative 0.0115 0.0266 0.1002
Plasmodium vivax acyl-CoA synthetase, putative 0.0074 0.0146 0.1508
Giardia lamblia Phosphoglycerate kinase 0.0352 0.0971 1
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0352 0.0971 0.3541
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0029 0.0012 0.0043
Brugia malayi Calcitonin receptor-like protein seb-1 0.0202 0.0526 0.3277
Echinococcus granulosus phosphoglycerate kinase 1 0.0352 0.0971 0.0971
Mycobacterium tuberculosis Diacylglycerol kinase 0.0036 0.0032 0.0118
Onchocerca volvulus 0.0067 0.0125 0.0892
Echinococcus granulosus intestinal type alkaline phosphatase 0.017 0.043 0.043
Echinococcus granulosus Diacylglycerol kinase theta 0.0036 0.0032 0.0032
Leishmania major acetyl-CoA synthetase, putative 0.0029 0.0012 0.0045
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0029 0.0012 0.0046
Toxoplasma gondii histone lysine methyltransferase SET1 0.0458 0.1287 1
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0043 0.0055 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0086 0.0536
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM10, putative 0.0047 0.0066 0.0676
Loa Loa (eye worm) hypothetical protein 0.0027 0.0006 0.0025
Schistosoma mansoni coup transcription factor 0.0032 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0029 0.0012 0.0047
Trypanosoma cruzi metacaspase 5, putative 0.0027 0.0006 0.0024
Brugia malayi TAR-binding protein 0.0062 0.0111 0.0694
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0035 0.0031 0.0031
Schistosoma mansoni DNA polymerase eta 0.0193 0.05 0.05
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0086 0.0536
Loa Loa (eye worm) hypothetical protein 0.0102 0.0229 0.0866
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0045 0.0458
Trypanosoma cruzi metacaspase, putative 0.0027 0.0006 0.0024
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0037 0.0136
Mycobacterium tuberculosis Conserved protein 0.0038 0.0037 0.014
Echinococcus multilocularis zinc finger protein 0.0054 0.0086 0.0086
Trichomonas vaginalis diacylglycerol kinase, putative 0.0036 0.0032 0.0198
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0025 0.0001 0.0007
Trypanosoma brucei ISWI complex protein 0.0025 0.0000025507 0.0000092979
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0025 0.0001 0.0012
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0057 0.0094 0.0354
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0111 0.0421
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0036 0.0032 0.0116
Schistosoma mansoni diacylglycerol kinase theta 0.0036 0.0032 0.0032
Onchocerca volvulus Alhambra homolog 0.003 0.0014 0.0103
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0061 0.0108 0.0108
Leishmania major 4-coumarate:coa ligase-like protein 0.0099 0.0221 0.0806
Schistosoma mansoni ferritin light chain 0.0025 0.0001 0.0001
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0012 0.0043
Brugia malayi steroid hormone receptor 0.0032 0.0021 0.0131
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0129 0.031 0.1128
Loa Loa (eye worm) hypothetical protein 0.0032 0.0021 0.0079
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.004 0.0045 0.0346
Echinococcus granulosus lysine specific demethylase 5A 0.0111 0.0256 0.0256
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0032 0.0021 0.0021
Mycobacterium tuberculosis Conserved protein 0.0916 0.2647 1
Echinococcus multilocularis peptidase Clp (S14 family) 0.0057 0.0094 0.0094
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0025 0.0001 0.0007
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0032 0.0021 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0032 0.0021 0.0131
Toxoplasma gondii hypothetical protein 0.0153 0.038 0.2954
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0021 0.0021
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0087 0.0183 0.1886
Toxoplasma gondii propionate-CoA ligase 0.0029 0.0012 0.0097
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0162 0.0409 0.1489
Echinococcus granulosus disco interacting protein 2 0.0043 0.0055 0.0055
Trypanosoma cruzi DNA damage repair protein, putative 0.0036 0.0031 0.0115
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0063 0.0114 0.1175
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0076 0.0151 0.0151
Leishmania major hypothetical protein, conserved 0.0038 0.0037 0.0136
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0114 0.0265 0.2062
Mycobacterium leprae Probable lipase LipE 0.0038 0.0037 0.0373
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0037 0.0385
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0449 0.1259 0.459
Loa Loa (eye worm) oxidoreductase 0.0029 0.0012 0.0047
Echinococcus granulosus methyl CpG binding domain protein 2 0.0035 0.0031 0.0031
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0029 0.0012 0.0043
Trypanosoma brucei DNA polymerase eta, putative 0.0193 0.05 0.1824
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0027 0.0098
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0086 0.0536
Loa Loa (eye worm) hypothetical protein 0.0032 0.0021 0.0079
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0036 0.0034 0.0034
Leishmania major metacaspase, putative 0.0027 0.0006 0.0024
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0037 0.014
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0115 0.0266 0.0266
Entamoeba histolytica hypothetical protein 0.0032 0.0021 0.0075
Brugia malayi Latrophilin receptor protein 2 0.0064 0.0116 0.0721
Plasmodium falciparum diacylglycerol kinase, putative 0.0036 0.0032 0.0327
Onchocerca volvulus 0.0032 0.0021 0.015
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0039 0.0041 0.0041
Schistosoma mansoni hypothetical protein 0.0088 0.0188 0.0188
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0029 0.0012 0.0045
Schistosoma mansoni retinoic acid receptor RXR 0.0032 0.0021 0.0021
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0086 0.0183 0.0686
Brugia malayi MH2 domain containing protein 0.0246 0.0658 0.4099
Schistosoma mansoni ferritin 0.0025 0.0001 0.0001
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0021 0.0131
Trypanosoma brucei phosphoglycerate kinase 0.0352 0.0971 0.3541
Leishmania major DNA polymerase kappa, putative 0.0036 0.0031 0.0115
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0029 0.0012 0.0046
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.008 0.0164 0.0164
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0032 0.0116
Echinococcus multilocularis fetal alzheimer antigen, falz 0.006 0.0105 0.0105
Echinococcus granulosus CTD small phosphatase protein like 0.0025 0.0001 0.0001
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0029 0.0012 0.0045
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0012 0.0043
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0031 0.0115
Trichomonas vaginalis dullard protein, putative 0.0025 0.0001 0.0007
Loa Loa (eye worm) hypothetical protein 0.0074 0.0146 0.0553
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0155 0.0387 0.0387
Onchocerca volvulus 0.0029 0.0012 0.0089
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0021 0.0131
Echinococcus multilocularis dna polymerase eta 0.0193 0.05 0.05
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0006 0.004
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0136 0.0331 0.1252
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0086 0.0536
Schistosoma mansoni myst-related protein 0.0032 0.0021 0.0021
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0352 0.0971 0.6051
Onchocerca volvulus 0.0099 0.0221 0.1584
Schistosoma mansoni caspase-7 (C14 family) 0.0027 0.0006 0.0006
Echinococcus multilocularis alkaline phosphatase 0.017 0.043 0.043
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0037 0.014
Onchocerca volvulus 0.0495 0.1396 1
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0029 0.0012 0.0097
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0352 0.0971 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0032 0.0021 0.0079
Trypanosoma brucei DNA polymerase kappa, putative 0.0142 0.0349 0.1272
Brugia malayi jmjC domain containing protein 0.0155 0.0387 0.2413
Onchocerca volvulus 0.0047 0.0065 0.0462
Schistosoma mansoni ap endonuclease 0.008 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.0102 0.0228 0.0862
Toxoplasma gondii hypothetical protein 0.0087 0.0183 0.1423
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0037 0.0141
Trypanosoma cruzi ISWI complex protein 0.0032 0.002 0.0072
Loa Loa (eye worm) RNA binding protein 0.0062 0.0111 0.0421
Trypanosoma cruzi DNA polymerase eta, putative 0.0193 0.05 0.1824
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0032 0.0021 0.0079
Trichomonas vaginalis bmru protein, putative 0.0036 0.0032 0.0198
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0111 0.0111
Echinococcus granulosus ecdysone induced protein 78C 0.0032 0.0021 0.0021
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0027 0.0006 0.005
Echinococcus granulosus Diacylglycerol kinase zeta 0.0036 0.0032 0.0032
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0065 0.0462
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0032 0.0021 0.0079
Plasmodium falciparum metacaspase 1 0.0027 0.0006 0.0067
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0084 0.0084
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.003 0.0014 0.0147
Toxoplasma gondii diacylglycerol kinase catalytic domain-containing protein 0.0036 0.0032 0.0247
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0025 0.0001 0.0004
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.007 0.0134 0.0506
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0029 0.0012 0.0046
Toxoplasma gondii TIM10 family protein, putative 0.0047 0.0066 0.051
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0021 0.0131
Brugia malayi hypothetical protein 0.0036 0.0032 0.0198
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0084 0.0084
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0034 0.0027 0.0097
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0034 0.0027 0.0098
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0014 0.0055
Trypanosoma cruzi DNA polymerase eta, putative 0.0114 0.0265 0.0967
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0136 0.0331 0.2064
Brugia malayi ecdysteroid receptor 0.0032 0.0021 0.0131
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0948 0.2743 1
Schistosoma mansoni phosphoglycerate kinase 0.0352 0.0971 0.0971
Trypanosoma cruzi DNA polymerase kappa, putative 0.0142 0.0349 0.1272
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0006 0.004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0054 0.0086 0.0536
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.003 0.0014 0.0135
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0061 0.0108 0.0108
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0029 0.0012 0.0043
Loa Loa (eye worm) transport to inner mitochondrial membrane family member 0.0047 0.0066 0.0248
Echinococcus multilocularis peregrin 0.0035 0.0029 0.0029
Trypanosoma cruzi DNA polymerase kappa, putative 0.0142 0.0349 0.1272
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0042 0.0052 0.0404
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0006 0.004
Mycobacterium ulcerans lipase LipD 0.0038 0.0037 0.0137
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0065 0.0065
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0021 0.0131
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0099 0.0221 0.0831
Trypanosoma brucei unspecified product 0.0079 0.0161 0.0586
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0035 0.0029 0.0111
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.017 0.043 0.043
Brugia malayi Cell death protein 3 precursor 0.0027 0.0006 0.004
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0012 0.0043
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0064 0.0116 0.0116
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0027 0.0006 0.0006
Echinococcus multilocularis geminin 0.0341 0.0941 0.0941
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0079 0.0161 0.061
Loa Loa (eye worm) hypothetical protein 0.0036 0.0032 0.012
Echinococcus multilocularis phosphoglycerate kinase 1 0.0352 0.0971 0.0971
Trypanosoma brucei Diacylglycerol kinase catalytic domain containing protein, putative 0.0036 0.0032 0.0116
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0021 0.0021
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0084 0.0084
Brugia malayi F/Y-rich N-terminus family protein 0.0089 0.0189 0.1179
Loa Loa (eye worm) hypothetical protein 0.0064 0.0116 0.0437
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0129 0.031 0.1128
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0065 0.0244
Loa Loa (eye worm) hypothetical protein 0.0074 0.0146 0.0553
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0029 0.0012 0.0045
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0074 0.0146 0.0146
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0039 0.0041 0.0041
Loa Loa (eye worm) histone methyltransferase 0.0076 0.0151 0.0572
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0086 0.0183 0.044
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0064 0.0116 0.0116
Trichomonas vaginalis DNA helicase recq, putative 0.005 0.0075 0.0464
Onchocerca volvulus Protein ultraspiracle homolog 0.0032 0.0021 0.015
Entamoeba histolytica exodeoxyribonuclease III, putative 0.008 0.0164 0.0616
Echinococcus multilocularis dnaJ subfamily B 0.339 1 1
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0136 0.0331 0.1208
Treponema pallidum exodeoxyribonuclease (exoA) 0.008 0.0164 0.168
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0035 0.0029 0.0183
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0054 0.0086 0.0536
Trypanosoma brucei DNA damage repair protein, putative 0.0036 0.0031 0.0115
Trichomonas vaginalis esterase, putative 0.0038 0.0037 0.0233
Plasmodium vivax phosphoglycerate kinase, putative 0.0352 0.0971 1
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0029 0.0012 0.0043
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0137 0.0333 0.0333
Plasmodium falciparum diacylglycerol kinase, putative 0.0036 0.0032 0.0327
Trypanosoma brucei phosphoglycerate kinase, putative 0.0129 0.031 0.1128
Schistosoma mansoni alkaline phosphatase 0.017 0.043 0.043
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.008 0.0164 0.0598
Trichomonas vaginalis antibiotic synthetase, putative 0.0029 0.0012 0.0078
Schistosoma mansoni ferritin light chain 0.0025 0.0001 0.0001
Echinococcus granulosus caspase 2 0.0027 0.0006 0.0006
Plasmodium vivax DNA repair protein REV1, putative 0.0036 0.0031 0.0324
Loa Loa (eye worm) MH2 domain-containing protein 0.0246 0.0658 0.2486
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0014 0.0014
Brugia malayi jmjC domain containing protein 0.0111 0.0256 0.1596
Loa Loa (eye worm) jmjC domain-containing protein 0.0111 0.0256 0.0968
Echinococcus multilocularis ceramide kinase 0.0036 0.0032 0.0032
Brugia malayi ImpB/MucB/SamB family protein 0.0115 0.0266 0.166
Echinococcus granulosus geminin 0.0341 0.0941 0.0941
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0043 0.0052 0.0052
Loa Loa (eye worm) latrophilin receptor protein 2 0.0064 0.0116 0.0437
Entamoeba histolytica diacylglycerol kinase, putative 0.0036 0.0032 0.0115
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0006 0.004
Trichomonas vaginalis sphingosine kinase, putative 0.0036 0.0032 0.0198
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.008 0.0164 0.0598
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0032 0.0021 0.0021
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0136 0.0331 0.0331
Brugia malayi PHD-finger family protein 0.0027 0.0007 0.0042
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0039 0.0041 0.0419
Loa Loa (eye worm) hypothetical protein 0.0047 0.0065 0.0244
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0021 0.0131
Trypanosoma brucei metacaspase MCA2 0.0027 0.0006 0.0024
Brugia malayi Bromodomain containing protein 0.0169 0.0427 0.2659
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0039 0.0041 0.0316
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0099 0.0221 0.0834
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0029 0.0012 0.0043
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0012 0.0043
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0054 0.0086 0.0536
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0029 0.0012 0.0045
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0114 0.0415
Echinococcus multilocularis expressed protein 0.0047 0.0066 0.0066
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0006 0.004
Leishmania major DNA damage repair protein, putative 0.0036 0.0031 0.0115
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.02 0.0521 0.0521
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0065 0.0065
Mycobacterium ulcerans acyl-CoA synthetase 0.0099 0.0221 0.0831
Echinococcus multilocularis microtubule associated protein 2 0.0728 0.2089 0.2089
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0034 0.0027 0.0098
Entamoeba histolytica acyl-CoA synthetase, putative 0.0099 0.0221 0.0831
Echinococcus granulosus tar DNA binding protein 0.0062 0.0111 0.0111
Schistosoma mansoni ferritin 0.0025 0.0001 0.0001
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0012 0.0078
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0054 0.0086 0.0536
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0025 0.0001 0.0001
Schistosoma mansoni apoferritin-2 0.0025 0.0001 0.0001
Brugia malayi Bromodomain containing protein 0.0079 0.0161 0.1003
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0122 0.0287 0.1082
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0006 0.004
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0136 0.0331 0.0331
Schistosoma mansoni hypothetical protein 0.0032 0.002 0.002
Trichomonas vaginalis DNA polymerase eta, putative 0.0142 0.0349 0.2173
Schistosoma mansoni hypothetical protein 0.0148 0.0366 0.0366
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0038 0.0037 0.0141
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0029 0.0012 0.0046
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0021 0.0131
Toxoplasma gondii diacylglycerol kinase accessory domain (presumed) domain-containing protein 0.0036 0.0032 0.0247
Echinococcus multilocularis caspase 8 0.0027 0.0006 0.0006
Echinococcus granulosus sphingosine kinase 1 0.0916 0.2647 0.2647
Onchocerca volvulus 0.0036 0.0032 0.0227
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0067 0.0125 0.0125
Schistosoma mansoni glutaminase 0.0565 0.1605 0.1605
Schistosoma mansoni diacylglycerol kinase zeta iota 0.0036 0.0032 0.0032
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0031 0.0115
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0006 0.004
Mycobacterium ulcerans acyl-CoA synthetase 0.0099 0.0221 0.0831
Echinococcus granulosus expressed protein 0.0047 0.0066 0.0066
Echinococcus multilocularis thyroid hormone receptor alpha 0.0032 0.0021 0.0021
Brugia malayi Disco-interacting protein 2 homolog 0.0039 0.0043 0.0267
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0122 0.0287 0.1046
Brugia malayi RNA binding protein 0.0062 0.0111 0.0694
Brugia malayi beta-lactamase family protein 0.0038 0.0037 0.0233
Brugia malayi Phosphoglycerate kinase 0.0129 0.031 0.1929
Echinococcus granulosus dna polymerase kappa 0.0142 0.0349 0.0349
Schistosoma mansoni sphingosine kinase A B 0.0916 0.2647 0.2647
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0067 0.0125 0.0968
Leishmania major DNA polymerase eta, putative 0.0193 0.05 0.1824
Leishmania major hypothetical protein, conserved 0.0036 0.0032 0.0116
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0032 0.0021 0.015
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0067 0.0125 0.0125
Leishmania major acetyl-CoA synthetase, putative 0.0029 0.0012 0.0045
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0037 0.0233
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0133 0.0322 0.1174
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.009 0.009
Leishmania major diacylglycerol kinase, putative 0.0036 0.0032 0.0116
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0352 0.0971 0.3541
Loa Loa (eye worm) hypothetical protein 0.0038 0.0037 0.0141
Brugia malayi latrophilin 2 splice variant baaae 0.0138 0.0336 0.2094
Loa Loa (eye worm) hypothetical protein 0.0146 0.036 0.1361
Trypanosoma brucei phosphoglycerate kinase 0.0352 0.0971 0.3541
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.003 0.0014 0.0147
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0037 0.0137
Schistosoma mansoni hypothetical protein 0.0341 0.0941 0.0941
Schistosoma mansoni diacylglycerol kinase theta 0.0036 0.0032 0.0032
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0037 0.0233
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0032 0.0021 0.0131
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0032 0.0116
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0507 0.1433 0.1433
Trypanosoma cruzi DNA polymerase kappa, putative 0.0142 0.0349 0.1272
Onchocerca volvulus Cell death protein 3 homolog 0.0027 0.0006 0.0046
Schistosoma mansoni steroid hormone receptor ad4bp 0.0032 0.0021 0.0021
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0054 0.0086 0.0536
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.004 0.0045 0.0458
Echinococcus multilocularis expressed protein 0.0035 0.0029 0.0029
Trypanosoma brucei DNA polymerase kappa, putative 0.0142 0.0349 0.1272
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0099 0.0221 0.0831
Loa Loa (eye worm) bromodomain containing protein 0.0037 0.0034 0.0129
Mycobacterium ulcerans phosphoglycerate kinase 0.0352 0.0971 0.3667
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0111 0.0694
Loa Loa (eye worm) hypothetical protein 0.0036 0.0032 0.012
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.008 0.0164 0.0164
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0065 0.0065
Plasmodium vivax hypothetical protein, conserved 0.003 0.0014 0.0149
Brugia malayi photoreceptor-specific nuclear receptor 0.0032 0.0021 0.0131
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0006 0.004
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0111 0.0421
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.0021 0.0021
Loa Loa (eye worm) beta-lactamase 0.0038 0.0037 0.0141
Mycobacterium ulcerans glutaminase 0.0565 0.1605 0.6062
Loa Loa (eye worm) hypothetical protein 0.0138 0.0336 0.127
Trichomonas vaginalis ap endonuclease, putative 0.008 0.0164 0.1022
Plasmodium vivax diacylglycerol kinase, putative 0.0036 0.0032 0.0327
Schistosoma mansoni jumonji/arid domain-containing protein 0.0111 0.0256 0.0256
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0006 0.004
Trypanosoma brucei DNA polymerase IV, putative 0.0142 0.0349 0.1272
Leishmania major 4-coumarate:coa ligase-like protein 0.0099 0.0221 0.0806
Schistosoma mansoni nuclear hormone receptor 0.0032 0.0021 0.0021
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.008 0.0164 0.169
Echinococcus granulosus histone lysine methyltransferase setb 0.0102 0.0229 0.0229
Trichomonas vaginalis sphingosine kinase, putative 0.0036 0.0032 0.0198
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0032 0.0021 0.0079
Echinococcus granulosus endonuclease exonuclease phosphatase 0.02 0.0521 0.0521
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0202 0.0526 0.1987
Leishmania major phosphoglycerate kinase C, glycosomal 0.0352 0.0971 0.3541
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.008 0.0164 0.169
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0029 0.0012 0.0012
Mycobacterium tuberculosis Possible penicillin-binding protein 0.024 0.0639 0.2413
Schistosoma mansoni jumonji/arid domain-containing protein 0.0111 0.0256 0.0256
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0111 0.0111
Trypanosoma brucei DNA polymerase kappa, putative 0.0142 0.0349 0.1272
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0133 0.0322 0.1174
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0142 0.0349 0.2173
Mycobacterium ulcerans acetyl-CoA synthetase 0.0029 0.0012 0.0043
Brugia malayi diacylglycerol kinase 0.0036 0.0032 0.0198
Schistosoma mansoni jumonji domain containing protein 0.0135 0.0328 0.0328
Leishmania major hypothetical protein, conserved 0.0025 0.0001 0.0004
Onchocerca volvulus 0.0272 0.0735 0.5264
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0032 0.0021 0.0021
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0086 0.0183 0.0183
Trichomonas vaginalis hypothetical protein 0.0029 0.0012 0.0073
Entamoeba histolytica phosphoglycerate kinase, putative 0.0352 0.0971 0.3667
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.008 0.0164 0.0619
Entamoeba histolytica diacylglycerol kinase, putative 0.0036 0.0032 0.0115
Toxoplasma gondii mitochondrial import inner membrane translocase subunit TIM10, putative 0.0047 0.0066 0.051
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0001 0.0004
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.005 0.0075 0.0272
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0025 0.0001 0.0007
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.009 0.009
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0012 0.0043
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1725 0.5052 0.5052
Echinococcus multilocularis caspase 2 0.0027 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.003 0.0014 0.0014
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0109 0.0411
Trichomonas vaginalis antibiotic synthetase, putative 0.0029 0.0012 0.0078
Toxoplasma gondii diacylglycerol kinase, putative 0.0036 0.0032 0.0247
Schistosoma mansoni ap endonuclease 0.008 0.0164 0.0164
Plasmodium falciparum metacaspase-like protein 0.0027 0.0006 0.0067
Trypanosoma brucei diacylglycerol kinase, putative 0.0036 0.0032 0.0116
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0029 0.0012 0.0073
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0032 0.0021 0.0021
Schistosoma mansoni DNA helicase recq1 0.0039 0.0041 0.0041
Schistosoma mansoni phosphoglycerate kinase 0.0352 0.0971 0.0971
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0086 0.0183 0.1872
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0352 0.0971 0.7546
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0037 0.0037
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.008 0.0164 0.0598
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0129 0.031 0.1128
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0006 0.004
Brugia malayi Pre-SET motif family protein 0.0435 0.122 0.7599
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0037 0.0136
Loa Loa (eye worm) hypothetical protein 0.0029 0.0012 0.0047
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0027 0.0006 0.0006
Schistosoma mansoni DNA helicase recq5 0.0039 0.0041 0.0041
Echinococcus multilocularis acylglycerol kinase, mitochondrial 0.0036 0.0032 0.0032
Brugia malayi hypothetical protein 0.0036 0.0033 0.0206
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0065 0.0065
Onchocerca volvulus 0.0039 0.0043 0.0307
Trypanosoma cruzi ISWI complex protein 0.0032 0.002 0.0072
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0133 0.0322 0.1174
Toxoplasma gondii hypothetical protein 0.003 0.0014 0.0111
Loa Loa (eye worm) eye-specific diacylglycerol kinase 0.0036 0.0032 0.012
Loa Loa (eye worm) hypothetical protein 0.0032 0.0021 0.0079
Loa Loa (eye worm) hypothetical protein 0.0086 0.0183 0.0691
Schistosoma mansoni rotamase 0.0035 0.0029 0.0029
Echinococcus multilocularis Diacylglycerol kinase theta 0.0036 0.0032 0.0032
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0031 0.0031
Brugia malayi Diacylglycerol kinase protein 2 0.0036 0.0032 0.0198
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0074 0.0146 0.0549
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0027 0.0006 0.004
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0086 0.0536
Plasmodium vivax metacaspase 1, putative 0.0027 0.0006 0.0067
Brugia malayi ImpB/MucB/SamB family protein 0.0193 0.05 0.3117
Echinococcus granulosus peptidase Clp S14 family 0.0057 0.0094 0.0094
Trypanosoma cruzi diacylglycerol kinase, putative 0.0036 0.0032 0.0116
Schistosoma mansoni hypothetical protein 0.0064 0.0116 0.0116
Leishmania major hypothetical protein, conserved 0.0036 0.0032 0.0116
Echinococcus granulosus zinc finger protein 0.0054 0.0086 0.0086
Echinococcus multilocularis disco interacting protein 2 0.0043 0.0055 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0032 0.0021 0.0131
Entamoeba histolytica hypothetical protein 0.0148 0.0366 0.1377
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0025 0.0001 0.0012
Leishmania major hypothetical protein, conserved 0.0032 0.002 0.0072
Entamoeba histolytica diacylglycerol kinase, putative 0.0036 0.0032 0.0115
Mycobacterium tuberculosis Conserved hypothetical protein 0.0115 0.0266 0.1005
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0029 0.0012 0.0046
Trichomonas vaginalis glutaminase, putative 0.0565 0.1605 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.007 0.0134 0.0506
Giardia lamblia DINP protein human, muc B family 0.0122 0.0287 0.2945
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0065 0.0065
Brugia malayi SET domain containing protein 0.003 0.0014 0.0084
Mycobacterium tuberculosis Conserved protein 0.0038 0.0037 0.014
Brugia malayi Pre-SET motif family protein 0.0067 0.0125 0.0776
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0012 0.0046
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0027 0.0098
Schistosoma mansoni hypothetical protein 0.0064 0.0116 0.0116
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0063 0.0112 0.0869
Trypanosoma brucei DNA polymerase kappa, putative 0.0142 0.0349 0.1272
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.003 0.0014 0.0135
Loa Loa (eye worm) hypothetical protein 0.0193 0.05 0.189
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0148 0.0366 0.0366
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0099 0.0221 0.0834
Schistosoma mansoni bromodomain containing protein 0.0144 0.0355 0.0355
Trypanosoma brucei DNA polymerase kappa, putative 0.0086 0.0181 0.066
Echinococcus multilocularis Diacylglycerol kinase zeta 0.0036 0.0032 0.0032
Loa Loa (eye worm) transcription factor SMAD2 0.0246 0.0658 0.2486
Brugia malayi AMP-binding enzyme family protein 0.0099 0.0221 0.1378
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0449 0.1259 0.459
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0435 0.122 0.4608
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0099 0.0221 0.0831
Echinococcus multilocularis caspase 0.0027 0.0006 0.0006
Echinococcus granulosus caspase 8 0.0027 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.0043 0.0053 0.0053
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0014 0.0014
Entamoeba histolytica hypothetical protein, conserved 0.0916 0.2647 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0032 0.012
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0049 0.0049
Trichomonas vaginalis rotamase, putative 0.0034 0.0027 0.0167
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0155 0.0387 0.0387
Loa Loa (eye worm) hypothetical protein 0.0038 0.0037 0.0141
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0032 0.0021 0.0131
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0115 0.0266 0.0266
Schistosoma mansoni cpg binding protein 0.029 0.0787 0.0787
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.008 0.0164 0.0598
Schistosoma mansoni hypothetical protein 0.03 0.0817 0.0817
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.007 0.0134 0.0506
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0029 0.0012 0.0116
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0029 0.0012 0.0046
Brugia malayi Eye-specific diacylglycerol kinase 0.0036 0.0032 0.0198
Trichomonas vaginalis bmru protein, putative 0.0036 0.0032 0.0198
Echinococcus granulosus dna polymerase eta 0.0193 0.05 0.05
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0036 0.0032 0.0116
Onchocerca volvulus 0.0038 0.0037 0.0268
Schistosoma mansoni hypothetical protein 0.0341 0.0941 0.0941
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0012 0.0046
Brugia malayi nuclear receptor NHR-88 0.0032 0.0021 0.0131
Loa Loa (eye worm) hypothetical protein 0.0032 0.0021 0.0079
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0012 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0086 0.0536
Loa Loa (eye worm) hypothetical protein 0.0053 0.0083 0.0315
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0027 0.0006 0.0006
Trichomonas vaginalis DNA helicase recq, putative 0.0094 0.0204 0.1273
Plasmodium falciparum zinc finger protein, putative 0.0032 0.0021 0.0216
Brugia malayi AMP-binding enzyme family protein 0.0099 0.0221 0.1378
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0006 0.0067
Plasmodium vivax SET domain protein, putative 0.0067 0.0125 0.1283
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0102 0.0229 0.0229
Mycobacterium ulcerans beta-lactamase 0.0038 0.0037 0.0137
Echinococcus multilocularis L aminoadipate semialdehyde 0.0085 0.0178 0.0178
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0086 0.0183 0.0686
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0031 0.0115
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0039 0.0041 0.0254
Mycobacterium tuberculosis Conserved hypothetical protein 0.0499 0.141 0.5326
Trypanosoma brucei unspecified product 0.0135 0.0328 0.1197
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0136 0.0331 0.1208
Trypanosoma cruzi DNA polymerase kappa, putative 0.0142 0.0349 0.1272
Loa Loa (eye worm) hypothetical protein 0.0038 0.0037 0.0141
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0039 0.0041 0.0154
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0086 0.0536
Schistosoma mansoni terminal deoxycytidyl transferase 0.0115 0.0266 0.0266
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0025 0.0001 0.0001
Trichomonas vaginalis diacylglycerol kinase, putative 0.0036 0.0032 0.0198
Brugia malayi PHD-finger family protein 0.003 0.0014 0.009
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0449 0.1259 0.459
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0082 0.017 0.1755
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0099 0.0221 0.2267
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0014 0.0014

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.3115 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 2.8184 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 5.6234 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3535 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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