Detailed information for compound 1460795

Basic information

Technical information
  • TDR Targets ID: 1460795
  • Name: 4-fluoro-N'-[2-hydroxy-2,2-di(phenyl)acetyl]- N-phenylbenzohydrazide
  • MW: 440.466 | Formula: C27H21FN2O3
  • H donors: 2 H acceptors: 3 LogP: 5.07 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)C(=O)N(c1ccccc1)NC(=O)C(c1ccccc1)(c1ccccc1)O
  • InChi: 1S/C27H21FN2O3/c28-23-18-16-20(17-19-23)25(31)30(24-14-8-3-9-15-24)29-26(32)27(33,21-10-4-1-5-11-21)22-12-6-2-7-13-22/h1-19,33H,(H,29,32)
  • InChiKey: RMKRZUILDZNEKF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-fluoro-N'-[2-hydroxy-2,2-di(phenyl)acetyl]-N-phenyl-benzohydrazide
  • 4-fluoro-N'-[2-hydroxy-1-oxo-2,2-di(phenyl)ethyl]-N-phenylbenzohydrazide
  • 4-fluoro-N'-[2-hydroxy-2,2-di(phenyl)ethanoyl]-N-phenyl-benzohydrazide
  • 4-fluoro-N'-[hydroxy(diphenyl)acetyl]-N-phenylbenzohydrazide
  • MLS000584237
  • SMR000203400
  • ChemDiv1_019460

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0035 0.0086 0.0074
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.0311 0.1746
Schistosoma mansoni zinc finger protein 0.0046 0.0154 0.0142
Mycobacterium ulcerans hypothetical protein 0.0075 0.0322 0.0621
Echinococcus granulosus jumonji domain containing protein 0.004 0.0116 0.0103
Onchocerca volvulus 0.0033 0.008 0.024
Mycobacterium ulcerans acyl-CoA synthetase 0.0075 0.0322 0.0621
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0035 0.0086 0.0074
Loa Loa (eye worm) hypothetical protein 0.0042 0.0129 0.0238
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0023 0.0022 0.0013
Leishmania major hypothetical protein, conserved 0.0035 0.0086 0.0193
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0079 0.0137
Brugia malayi photoreceptor-specific nuclear receptor 0.0033 0.008 0.0139
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0075 0.0322 0.0687
Schistosoma mansoni voltage-gated potassium channel 0.0035 0.0086 0.0074
Loa Loa (eye worm) hypothetical protein 0.0242 0.129 0.2613
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.023 0.0431
Loa Loa (eye worm) hypothetical protein 0.0033 0.008 0.0139
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0097 0.2734
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0164 0.0836 0.1686
Mycobacterium ulcerans acyl-CoA synthetase 0.0075 0.0322 0.0621
Loa Loa (eye worm) hypothetical protein 0.0055 0.0203 0.039
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0197 0.1026 0.1015
Brugia malayi Smad1 0.0026 0.0034 0.0045
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0075 0.0322 0.0687
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0315 0.0303
Schistosoma mansoni flap endonuclease-1 0.0026 0.0039 0.0027
Schistosoma mansoni zinc finger protein 0.0034 0.0081 0.0069
Schistosoma mansoni FFA transport protein 0.0801 0.4526 0.4519
Echinococcus multilocularis lysosomal alpha glucosidase 0.0164 0.0836 0.0825
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0035 0.0086 0.0074
Echinococcus granulosus FTZ F1 alpha 0.0033 0.008 0.0068
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0075 0.0322 0.0621
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0033 0.008 0.0139
Brugia malayi jmjC domain containing protein 0.0042 0.0129 0.0239
Loa Loa (eye worm) hypothetical protein 0.0252 0.1344 0.2724
Loa Loa (eye worm) hypothetical protein 0.0028 0.0051 0.0079
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0033 0.008 0.024
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0075 0.0322 0.0712
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0083 0.0366 0.071
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0075 0.0322 0.0675
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0079 0.0231
Brugia malayi Cyclic-nucleotide gated cation channel 0.0035 0.0086 0.0151
Loa Loa (eye worm) hypothetical protein 0.0075 0.0322 0.0634
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0101 0.0223
Schistosoma mansoni cpg binding protein 0.0065 0.0266 0.0254
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.0311 0.0597
Trichomonas vaginalis esterase, putative 0.0073 0.0311 0.9634
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0316 0.1716 0.3485
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0852 0.4824 0.4818
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.0311 0.0299
Onchocerca volvulus 0.0075 0.0322 0.2224
Plasmodium vivax acetyl-CoA synthetase, putative 0.0075 0.0322 0.4961
Echinococcus granulosus voltage dependent calcium channel 0.0852 0.4824 0.4818
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0427 0.236 0.2351
Schistosoma mansoni thyroid hormone receptor 0.0033 0.008 0.0068
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0051 0.0039
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0145 0.0727 0.1596
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0097 0.2734
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.0311 0.0662
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0354 0.1939 0.3941
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0142 0.0706 0.142
Brugia malayi MH1 domain containing protein 0.0026 0.0034 0.0045
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.0426 0.0414
Echinococcus multilocularis ecdysone induced protein 78C 0.0033 0.008 0.0068
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.023 0.0431
Leishmania major 4-coumarate:coa ligase-like protein 0.0075 0.0322 0.0722
Leishmania major pyruvate kinase 0.0033 0.0079 0.0178
Onchocerca volvulus 0.0095 0.0436 0.3155
Brugia malayi PHD-finger family protein 0.0058 0.0222 0.0429
Schistosoma mansoni transient receptor potential channel 0.0035 0.0086 0.0074
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0026 0.0035 0.0041
Brugia malayi Bromodomain containing protein 0.0168 0.086 0.1733
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.0311 0.0662
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0101 0.0517
Leishmania major hypothetical protein, conserved 0.013 0.0637 0.1427
Echinococcus granulosus short transient receptor potential channel 6 0.0035 0.0086 0.0074
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0317 0.1722 1
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0311 0.9634
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0079 0.0346 0.0729
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0035 0.0086 0.0074
Leishmania major acetyl-CoA synthetase, putative 0.0075 0.0322 0.0722
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0075 0.0322 0.0675
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0035 0.0086 0.0151
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0023 0.001
Echinococcus granulosus lysine specific demethylase 5A 0.0042 0.0129 0.0117
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0086 0.0073
Toxoplasma gondii ABC1 family protein 0.0073 0.0311 0.1949
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.008 0.0139
Loa Loa (eye worm) hypothetical protein 0.0035 0.0086 0.0151
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0035 0.0086 0.0074
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0852 0.4824 0.4818
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0164 0.0152
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0203 0.039
Toxoplasma gondii hypothetical protein 0.0252 0.1344 0.8694
Echinococcus multilocularis cpg binding protein 0.0065 0.0266 0.0254
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0075 0.0322 0.0712
Echinococcus granulosus pyruvate kinase 0.0033 0.0079 0.0067
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0035 0.0086 0.0151
Brugia malayi AMP-binding enzyme family protein 0.0075 0.0322 0.0634
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0097 0.167
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0033 0.008 0.0068
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0097 0.2734
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.0801 0.4526 1
Mycobacterium leprae possible long-chain acyl-CoA synthase 0.079 0.4465 1
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0017 0.0136
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0112 0.0533 0.1161
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0035 0.0086 0.0482
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0035 0.0086 0.0074
Loa Loa (eye worm) hypothetical protein 0.0073 0.0311 0.0611
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0097 0.2734
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0025 0.0056
Echinococcus granulosus ecdysone induced protein 78C 0.0033 0.008 0.0068
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0097 0.0173
Echinococcus granulosus Smad4 0.0026 0.0034 0.0022
Echinococcus multilocularis transient receptor potential gamma protein 0.0035 0.0086 0.0074
Loa Loa (eye worm) hypothetical protein 0.0307 0.1665 0.338
Brugia malayi Importin beta-1 subunit 0.003 0.0058 0.0093
Trypanosoma brucei ISWI complex protein 0.0034 0.0081 0.04
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0075 0.0322 0.0722
Giardia lamblia TCP-1 chaperonin subunit beta 0.0024 0.0023 0.1156
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0035 0.0086 0.0074
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0035 0.0086 0.0151
Brugia malayi CXXC zinc finger family protein 0.0058 0.0222 0.0429
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0112 0.0536 0.0524
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0311 0.9634
Entamoeba histolytica Flap nuclease, putative 0.0029 0.0055 0.0842
Onchocerca volvulus Huntingtin homolog 0.0239 0.1271 1
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0075 0.0322 0.0687
Echinococcus granulosus dnaJ subfamily B 0.0826 0.4672 0.4666
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0025 0.0414
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.0079 0.0128
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0075 0.0322 0.1812
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0075 0.0321 0.0309
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0035 0.0086 0.0193
Echinococcus multilocularis transient receptor potential cation channel 0.0035 0.0086 0.0074
Onchocerca volvulus 0.0073 0.0311 0.2131
Mycobacterium ulcerans acyl-CoA synthetase 0.0075 0.0322 0.0621
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0227 0.0438
Brugia malayi Bromodomain containing protein 0.0084 0.0373 0.0739
Mycobacterium ulcerans hypothetical protein 0.0073 0.0311 0.0597
Trypanosoma cruzi ISWI complex protein 0.0034 0.0081 0.0179
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0035 0.0086 0.0074
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0075 0.0322 0.0621
Entamoeba histolytica acyl-CoA synthetase, putative 0.0083 0.0366 0.6968
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0035 0.0086 0.0074
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0075 0.0322 0.0675
Loa Loa (eye worm) hypothetical protein 0.0354 0.1939 0.3941
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0079 0.2158
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0129 0.0117
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0097 0.167
Echinococcus granulosus shaker cognate 0.0035 0.0086 0.0074
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0101 0.5
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0033 0.008 0.0068
Schistosoma mansoni smad1 5 8 and 0.0026 0.0034 0.0022
Leishmania major fatty acid transporter protein-like protein 0.079 0.4465 1
Echinococcus granulosus potassium voltage gated channel protein 0.0035 0.0086 0.0074
Brugia malayi hypothetical protein 0.0109 0.052 0.1038
Onchocerca volvulus 0.0083 0.0366 0.2582
Onchocerca volvulus 0.0205 0.1075 0.84
Echinococcus granulosus muscleblind protein 0.0307 0.1665 0.1654
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0033 0.008 0.0139
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0023 0.001
Trichomonas vaginalis antibiotic synthetase, putative 0.0075 0.0322 1
Brugia malayi AMP-binding enzyme family protein 0.0075 0.0322 0.0634
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0035 0.0086 0.0151
Schistosoma mansoni cpg binding protein 0.0065 0.0266 0.0254
Schistosoma mansoni two-pore calcium channel 0.0035 0.0086 0.0074
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0079 0.0391
Brugia malayi MH2 domain containing protein 0.0026 0.0034 0.0045
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0164 0.0152
Loa Loa (eye worm) transcription factor SMAD2 0.0375 0.2061 0.419
Loa Loa (eye worm) hypothetical protein 0.0048 0.0164 0.0311
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0164 0.0152
Schistosoma mansoni hypothetical protein 0.0112 0.0536 0.0524
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0852 0.4824 0.4818
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0101 0.2854
Loa Loa (eye worm) hypothetical protein 0.0033 0.008 0.0139
Loa Loa (eye worm) hypothetical protein 0.0075 0.0322 0.0634
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0101 0.0089
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0048 0.0166 0.1
Echinococcus granulosus voltage gated hydrogen channel 1 0.0035 0.0086 0.0074
Echinococcus multilocularis transient receptor potential cation channel 0.0035 0.0086 0.0074
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0035 0.0086 0.0074
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0061 0.024 0.0502
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0852 0.4824 0.4818
Schistosoma mansoni steroid hormone receptor ad4bp 0.0033 0.008 0.0068
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0083 0.0366 0.071
Trypanosoma brucei glucosidase, putative 0.0036 0.0097 0.0495
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.079 0.4465 1
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0075 0.0319 0.068
Giardia lamblia Methyltransferase like 2 0.0022 0.0017 0.0477
Echinococcus granulosus transient receptor potential cation channel 0.0035 0.0086 0.0074
Echinococcus granulosus transient receptor potential cation channel 0.0035 0.0086 0.0074
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0311 0.0687
Echinococcus granulosus hypothetical protein 0.0035 0.0086 0.0074
Schistosoma mansoni hypothetical protein 0.1745 1 1
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0035 0.0086 0.0151
Loa Loa (eye worm) hypothetical protein 0.0035 0.0086 0.0151
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0024 0.0023 0.0202
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0051 0.0252
Brugia malayi latrophilin 2 splice variant baaae 0.0242 0.129 0.2613
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0033 0.008 0.0139
Loa Loa (eye worm) hypothetical protein 0.0286 0.1544 0.3134
Loa Loa (eye worm) hypothetical protein 0.013 0.0637 0.1278
Loa Loa (eye worm) hypothetical protein 0.0075 0.0322 0.0634
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0097 0.0085
Loa Loa (eye worm) hypothetical protein 0.0035 0.0086 0.0151
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0075 0.0322 0.0712
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0203 0.0191
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0097 0.0085
Echinococcus multilocularis peregrin 0.0034 0.0081 0.0069
Loa Loa (eye worm) hypothetical protein 0.0075 0.0322 0.0634
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0034 0.0045
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0033 0.008 0.0068
Plasmodium falciparum T-complex protein 1 subunit beta 0.0024 0.0023 0.0164
Leishmania major acetyl-CoA synthetase, putative 0.0075 0.0322 0.0722
Loa Loa (eye worm) hypothetical protein 0.0033 0.008 0.0139
Schistosoma mansoni hypothetical protein 0.0035 0.0086 0.0074
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0035 0.0086 0.0151
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0033 0.008 0.0139
Mycobacterium ulcerans acetyl-CoA synthetase 0.0075 0.0322 0.0621
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.008 0.0139
Echinococcus granulosus TRP transient receptor potential channel 0.0035 0.0086 0.0074
Schistosoma mansoni pyruvate kinase 0.0033 0.0079 0.0067
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0035 0.0086 0.0432
Echinococcus multilocularis pyruvate kinase 0.0033 0.0079 0.0067
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.0311 0.0662
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0035 0.0086 0.0074
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0101 0.0089
Schistosoma mansoni microtubule-associated protein tau 0.0671 0.3774 0.3766
Echinococcus granulosus transient receptor potential cation channel 0.0035 0.0086 0.0074
Leishmania major T-complex protein 1, beta subunit, putative 0.0024 0.0023 0.0051
Toxoplasma gondii transporter, cation channel family protein 0.0035 0.0086 0.0482
Mycobacterium ulcerans polyketide synthase 0.0079 0.0346 0.0669
Toxoplasma gondii hypothetical protein 0.0035 0.0086 0.0482
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0021 0.0167
Loa Loa (eye worm) hypothetical protein 0.0049 0.0169 0.032
Loa Loa (eye worm) beta-lactamase 0.0073 0.0311 0.0611
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.0311 0.0299
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0033 0.008 0.0068
Echinococcus multilocularis flap endonuclease 1 0.0029 0.0055 0.0043
Schistosoma mansoni transient receptor potential channel 0.0035 0.0086 0.0074
Toxoplasma gondii exonuclease III APE 0.0037 0.0101 0.0577
Echinococcus multilocularis ryanodine receptor 44f 0.0035 0.0086 0.0074
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0113 0.0539 0.0527
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0033 0.008 0.0139
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0054 0.0197 0.0406
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0042 0.0132 0.026
Schistosoma mansoni voltage-dependent calcium channel 0.0035 0.0086 0.0074
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.0086 0.2383
Echinococcus multilocularis sodium leak channel non selective protein 0.0035 0.0086 0.0074
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0035 0.0086 0.0074
Echinococcus granulosus ryanodine receptor 44f 0.0035 0.0086 0.0074
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.008 0.0068
Echinococcus multilocularis two pore calcium channel protein 1 0.0035 0.0086 0.0074
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0029 0.0055 0.0279
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0035 0.0086 0.0151
Brugia malayi ecdysteroid receptor 0.0033 0.008 0.0139
Loa Loa (eye worm) hypothetical protein 0.0035 0.0086 0.0151
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.023 0.0217
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0033 0.008 0.0139
Mycobacterium ulcerans acyl-CoA synthetase 0.0075 0.0322 0.0621
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0029 0.0055 0.0122
Schistosoma mansoni hypothetical protein 0.1745 1 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0311 0.0611
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0075 0.0322 0.0687
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0033 0.008 0.0139
Schistosoma mansoni alpha glucosidase 0.0036 0.0097 0.0085
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0101 0.0189
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0079 0.0346 0.074
Loa Loa (eye worm) hypothetical protein 0.0035 0.0086 0.0151
Brugia malayi Latrophilin receptor protein 2 0.0112 0.0536 0.1071
Plasmodium vivax flap endonuclease 1, putative 0.0029 0.0055 0.0684
Schistosoma mansoni retinoic acid receptor RXR 0.0033 0.008 0.0068
Echinococcus multilocularis potassium voltage gated channel protein 0.0035 0.0086 0.0074
Mycobacterium ulcerans acyl-CoA synthetase 0.0075 0.0322 0.0621
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0049 0.0172 0.0338
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0024 0.0023 0.006
Loa Loa (eye worm) hypothetical protein 0.0033 0.008 0.0139
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0109 0.052 0.0508
Schistosoma mansoni voltage-gated potassium channel 0.0035 0.0086 0.0074
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0075 0.0322 0.0621
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0035 0.0086 0.0074
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0079 0.0346 0.0669
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0427 0.236 0.2351
Brugia malayi AMP-binding enzyme family protein 0.0075 0.0322 0.0634
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0035 0.0086 0.0191
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0048 0.0167 0.1009
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.0311 0.0597
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0042 0.0961
Schistosoma mansoni ap endonuclease 0.0037 0.0101 0.0089
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0075 0.0322 0.0621
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0311 0.0299
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0033 0.008 0.0068
Loa Loa (eye worm) calcium channel 0.0852 0.4824 0.9843
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0097 0.2734
Loa Loa (eye worm) hypothetical protein 0.0084 0.0374 0.074
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0083 0.0366 0.0785
Schistosoma mansoni acetyl-CoA synthetase 0.0075 0.0322 0.031
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0113 0.0539 0.0527
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0035 0.0086 0.0151
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0317 0.1722 0.3806
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0075 0.0322 0.0621
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0058 0.0223 0.0211
Loa Loa (eye worm) T-complex protein 1 0.0024 0.0023 0.0021
Schistosoma mansoni voltage-gated potassium channel 0.0035 0.0086 0.0074
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0035 0.0086 0.0074
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0035 0.0086 0.0074
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0035 0.0086 0.0074
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0039 0.0111 0.0098
Loa Loa (eye worm) hypothetical protein 0.0035 0.0086 0.0151
Loa Loa (eye worm) jmjC domain-containing protein 0.0042 0.0129 0.0239
Loa Loa (eye worm) hypothetical protein 0.0097 0.0448 0.0891
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0852 0.4824 0.4818
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0033 0.008 0.0068
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0101 0.0223
Plasmodium vivax ataxin-2 like protein, putative 0.013 0.0637 1
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0852 0.4824 0.4818
Plasmodium falciparum phd finger protein, putative 0.0028 0.0051 0.0619
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0427 0.236 0.2351
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0079 0.0437
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0101 0.5
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0075 0.0322 0.4961
Loa Loa (eye worm) hypothetical protein 0.0035 0.0086 0.0151
Schistosoma mansoni voltage-gated potassium channel 0.0035 0.0086 0.0074
Schistosoma mansoni ap endonuclease 0.0037 0.0101 0.0089
Echinococcus granulosus peregrin 0.0034 0.0081 0.0069
Toxoplasma gondii melibiase subfamily protein 0.0113 0.0539 0.3435
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0025 0.0414
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.008 0.0068
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0101 0.1416
Loa Loa (eye worm) fatty acid synthase 0.0074 0.0313 0.0615
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0079 0.0175
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0035 0.0086 0.0151
Echinococcus multilocularis geminin 0.1745 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0427 0.236 0.2351
Trypanosoma cruzi PAB1-binding protein , putative 0.013 0.0637 0.1407
Schistosoma mansoni transient receptor potential channel 4 0.0035 0.0086 0.0074
Brugia malayi AMP-binding enzyme family protein 0.0145 0.0727 0.1461
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0865 0.4901 1
Echinococcus granulosus flap endonuclease 1 0.0029 0.0055 0.0043
Echinococcus multilocularis pyruvate kinase 0.0033 0.0079 0.0067
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0072 0.0306 0.065
Echinococcus granulosus hyperpolarization activated cyclic 0.0035 0.0086 0.0074
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0113 0.0539 0.0527
Loa Loa (eye worm) voltage-gated calcium channel 0.0035 0.0086 0.0151
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0023 0.001
Echinococcus granulosus transient receptor potential gamma protein 0.0035 0.0086 0.0074
Mycobacterium ulcerans polyketide synthase 0.0075 0.0319 0.0614
Onchocerca volvulus 0.0145 0.0727 0.5539
Echinococcus granulosus smad 0.0026 0.0034 0.0022
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0012 0.0027
Loa Loa (eye worm) hypothetical protein 0.0035 0.0086 0.0151
Loa Loa (eye worm) hypothetical protein 0.0033 0.008 0.0139
Brugia malayi MH2 domain containing protein 0.0375 0.2061 0.419
Echinococcus multilocularis hyperpolarization activated cyclic 0.0035 0.0086 0.0074
Onchocerca volvulus 0.0075 0.0322 0.2224
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0079 0.0346 0.074
Onchocerca volvulus Bile acid receptor homolog 0.0033 0.008 0.024
Loa Loa (eye worm) hypothetical protein 0.0035 0.0086 0.0151
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0037 0.0103 0.0091
Loa Loa (eye worm) hypothetical protein 0.0073 0.0311 0.0611
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0035 0.0086 0.0151
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0079 0.0137
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0033 0.008 0.0139
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0024 0.0024 0.0011
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0033 0.008 0.0068
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0112 0.0536 0.0524
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0033 0.008 0.0068
Schistosoma mansoni voltage-gated potassium channel 0.0035 0.0086 0.0074
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0075 0.0322 0.0687
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0051 0.0039
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0035 0.0086 0.0151
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0079 0.0346 0.074
Schistosoma mansoni voltage-gated potassium channel 0.0035 0.0086 0.0074
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.023 0.0217
Brugia malayi AMP-binding enzyme family protein 0.0033 0.008 0.0138
Loa Loa (eye worm) hypothetical protein 0.0035 0.0086 0.0151
Brugia malayi Transient-receptor-potential like protein 0.0035 0.0086 0.0151
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0035 0.0086 0.0074
Schistosoma mansoni voltage-gated potassium channel 0.0035 0.0086 0.0074
Echinococcus multilocularis mothers against decapentaplegic 5 0.0026 0.0034 0.0022
Schistosoma mansoni hypothetical protein 0.0242 0.129 0.1279
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0203 0.0191
Schistosoma mansoni smad1 5 8 and 0.0026 0.0034 0.0022
Loa Loa (eye worm) hypothetical protein 0.0035 0.0086 0.0151
Echinococcus granulosus long chain fatty acid transport protein 4 0.0801 0.4526 0.4519
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.006 0.0234 0.0441
Echinococcus multilocularis shaker cognate 0.0035 0.0086 0.0074
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0035 0.0086 0.0074
Mycobacterium tuberculosis Conserved protein 0.0073 0.0311 0.0662
Schistosoma mansoni cpg binding protein 0.0058 0.0222 0.021
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0033 0.008 0.0068
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0116 0.0103
Giardia lamblia PHD finger protein 15 0.0028 0.0051 0.4372
Echinococcus granulosus sodium leak channel non selective protein 0.0035 0.0086 0.0074
Loa Loa (eye worm) hypothetical protein 0.0239 0.1271 0.2574
Echinococcus granulosus lysosomal alpha glucosidase 0.0164 0.0836 0.0825
Mycobacterium leprae Probable polyketide synthase Pks1 0.0079 0.0346 0.0729
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.0311 0.0611
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0079 0.0137
Echinococcus granulosus mothers against decapentaplegic 5 0.0026 0.0034 0.0022
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0051 0.0252
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0427 0.236 0.2351
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0039 0.0111 0.0098
Echinococcus granulosus calcium activated potassium channel 0.0035 0.0086 0.0074
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0083 0.0366 0.071
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0203 0.0191
Leishmania major 4-coumarate:coa ligase-like protein 0.0075 0.0322 0.0722
Onchocerca volvulus Protein ultraspiracle homolog 0.0033 0.008 0.024
Leishmania major hypothetical protein, conserved 0.0073 0.0311 0.0696
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0035 0.0086 0.0151
Echinococcus multilocularis conserved hypothetical protein 0.0035 0.0086 0.0074
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0062 0.0247 0.0506
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0034 0.0045
Schistosoma mansoni hypothetical protein 0.0109 0.052 0.0508
Echinococcus granulosus fetal alzheimer antigen falz 0.0053 0.0192 0.018
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0026 0.0034 0.0022
Schistosoma mansoni voltage-gated ion channel 0.0035 0.0086 0.0074
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0035 0.0086 0.0074
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0035 0.0086 0.0151
Schistosoma mansoni voltage-gated potassium channel 0.0035 0.0086 0.0074
Echinococcus multilocularis voltage dependent calcium channel 0.0852 0.4824 0.4818
Onchocerca volvulus 0.0048 0.0164 0.093
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0097 0.0215
Schistosoma mansoni hypothetical protein 0.0028 0.0051 0.0039
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.003 0.0061 0.01
Echinococcus multilocularis two pore calcium channel protein 2 0.0035 0.0086 0.0074
Echinococcus granulosus two pore calcium channel protein 2 0.0035 0.0086 0.0074
Echinococcus multilocularis thyroid hormone receptor alpha 0.0033 0.008 0.0068
Schistosoma mansoni hypothetical protein 0.0826 0.4672 0.4666
Brugia malayi cation channel family protein 0.0035 0.0086 0.0151
Schistosoma mansoni voltage-gated potassium channel 0.0035 0.0086 0.0074
Entamoeba histolytica hypothetical protein 0.0109 0.052 1
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0027 0.0042 0.003
Loa Loa (eye worm) voltage-gated potassium channel 0.0035 0.0086 0.0151
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.023 0.0431
Brugia malayi T-complex protein 1, beta subunit 0.0024 0.0023 0.0021
Brugia malayi steroid hormone receptor 0.0033 0.008 0.0139
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0427 0.236 0.2351
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0035 0.0086 0.0074
Onchocerca volvulus Fatty acid synthase homolog 0.0135 0.0666 0.5045
Loa Loa (eye worm) Smad1 0.0026 0.0034 0.0045
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0079 0.0343 0.0331
Onchocerca volvulus 0.0058 0.0222 0.1404
Loa Loa (eye worm) hypothetical protein 0.0155 0.0786 0.1582
Brugia malayi nuclear receptor NHR-88 0.0033 0.008 0.0139
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.008 0.0068
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0075 0.0321 0.0309
Brugia malayi hypothetical protein 0.0084 0.0371 0.0733
Echinococcus granulosus two pore calcium channel protein 1 0.0035 0.0086 0.0074
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0097 0.0218
Brugia malayi F/Y-rich N-terminus family protein 0.0031 0.0067 0.0112
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.023 0.0217
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0024 0.0023 0.033
Brugia malayi AMP-binding enzyme family protein 0.0865 0.4901 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.008 0.0139
Echinococcus granulosus zinc finger protein 0.0046 0.0154 0.0142
Echinococcus multilocularis hyperpolarization activated cyclic 0.0035 0.0086 0.0074
Schistosoma mansoni methyl-cpg binding protein mbd 0.0037 0.0103 0.0091
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0083 0.0366 0.0785
Brugia malayi hypothetical protein 0.0035 0.0086 0.0151
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0852 0.4824 0.4818
Schistosoma mansoni nuclear hormone receptor 0.0033 0.008 0.0068
Echinococcus granulosus sodium channel protein 0.0035 0.0086 0.0074
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0035 0.0086 0.0074
Echinococcus granulosus TGF beta signal transducer SmadC 0.0026 0.0034 0.0022
Brugia malayi RNA, U transporter 1 0.0084 0.0374 0.0739
Entamoeba histolytica acyl-coA synthetase, putative 0.0075 0.0322 0.6107
Schistosoma mansoni RAR-like nuclear receptor 0.0033 0.008 0.0068
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0023 0.002 0.0045
Schistosoma mansoni importin beta-1 0.003 0.0058 0.0045
Echinococcus multilocularis Smad4 0.0026 0.0034 0.0022
Echinococcus multilocularis smad 0.0026 0.0034 0.0022
Brugia malayi PHD-finger family protein 0.0028 0.0051 0.0079
Loa Loa (eye worm) hypothetical protein 0.0035 0.0086 0.0151
Echinococcus multilocularis potassium voltage gated channel protein 0.0035 0.0086 0.0074
Plasmodium falciparum ataxin-2 like protein, putative 0.013 0.0637 1
Echinococcus multilocularis sodium channel protein 0.0065 0.0264 0.0252
Schistosoma mansoni transcription factor LCR-F1 0.0109 0.052 0.0508
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0079 0.0137
Plasmodium vivax hypothetical protein, conserved 0.0073 0.0311 0.478
Mycobacterium ulcerans polyketide synthase Pks9 0.0049 0.0172 0.0314
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0035 0.0086 0.0074
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0083 0.0366 0.0785
Loa Loa (eye worm) hypothetical protein 0.0073 0.0311 0.0611
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0035 0.0086 0.0074
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0075 0.0322 0.1812
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0468 0.2599 0.5806
Echinococcus multilocularis muscleblind protein 0.0307 0.1665 0.1654
Mycobacterium tuberculosis Conserved protein 0.0073 0.0311 0.0662
Leishmania major hypothetical protein, conserved 0.0022 0.0017 0.0037
Loa Loa (eye worm) acyl carrier protein 0.0034 0.0085 0.0149
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.0086 0.2383
Mycobacterium ulcerans acyl-CoA synthetase 0.0075 0.0322 0.0621
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.023 0.0217
Plasmodium falciparum importin beta, putative 0.003 0.0058 0.0724
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0075 0.0322 0.0634
Loa Loa (eye worm) hypothetical protein 0.0035 0.0086 0.0151
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0112 0.0536 0.0524
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0058 0.0265
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0079 0.2158
Onchocerca volvulus 0.0073 0.0311 0.2131
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0113 0.0539 0.0527
Schistosoma mansoni Smad4 0.0026 0.0034 0.0022
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0101 0.1743
Loa Loa (eye worm) hypothetical protein 0.0112 0.0536 0.1071
Mycobacterium ulcerans acyl-CoA synthetase 0.0075 0.0322 0.0621
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0035 0.0086 0.0074
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0145 0.0727 0.1461
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0023 0.0019 0.0006
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1692 0.9691 0.9691
Echinococcus multilocularis importin subunit beta 1 0.003 0.0058 0.0045
Plasmodium falciparum pyruvate kinase 0.0033 0.0079 0.1071
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0075 0.0322 0.0621
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0129 0.0117
Echinococcus multilocularis voltage gated potassium channel 0.0035 0.0086 0.0074
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0035 0.0086 0.0074
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0865 0.4901 1
Toxoplasma gondii type I fatty acid synthase, putative 0.0053 0.0194 0.1187
Loa Loa (eye worm) hypothetical protein 0.0307 0.1665 0.338
Loa Loa (eye worm) hypothetical protein 0.0073 0.0311 0.0611
Brugia malayi Melibiase family protein 0.0075 0.0321 0.0632
Toxoplasma gondii transporter, cation channel family protein 0.0035 0.0086 0.0482
Onchocerca volvulus 0.0035 0.0086 0.0289
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0852 0.4824 0.9843
Brugia malayi voltage-dependent calcium channel 0.0035 0.0086 0.0151
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0101 0.2854
Mycobacterium ulcerans lipase LipD 0.0073 0.0311 0.0597
Schistosoma mansoni alpha-glucosidase 0.0141 0.0704 0.0693
Loa Loa (eye worm) hypothetical protein 0.0239 0.1271 0.2574
Mycobacterium tuberculosis Conserved protein 0.0073 0.0311 0.0662
Trypanosoma brucei PAB1-binding protein , putative 0.013 0.0637 0.3652
Toxoplasma gondii LsmAD domain-containing protein 0.013 0.0637 0.4077
Echinococcus granulosus voltage dependent calcium channel 0.0286 0.1544 0.1534
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0079 0.0231
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0164 0.0152
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0065 0.0264 0.0252
Echinococcus multilocularis FTZ F1 alpha 0.0033 0.008 0.0068
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0097 0.0215
Loa Loa (eye worm) PHD-finger family protein 0.0045 0.0149 0.0279
Toxoplasma gondii FATC domain-containing protein 0.0027 0.0042 0.0194
Mycobacterium ulcerans Type I modular polyketide synthase 0.0075 0.0319 0.0614
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0203 0.0191
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0164 0.0152
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0065 0.0262 0.0551
Brugia malayi hypothetical protein 0.0239 0.1271 0.2574
Echinococcus multilocularis zinc finger protein 0.0046 0.0154 0.0142
Mycobacterium ulcerans Type I modular polyketide synthase 0.0075 0.0319 0.0614
Loa Loa (eye worm) voltage-gated potassium channel 0.0035 0.0086 0.0151
Brugia malayi Glycosyl hydrolases family 31 protein 0.0164 0.0836 0.1686
Mycobacterium ulcerans fatty acid synthase Fas 0.0023 0.0022 0.0006
Toxoplasma gondii t-complex protein beta subunit 0.0024 0.0023 0.0067
Brugia malayi ion channel NompC 0.0035 0.0086 0.0151
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0112 0.0536 0.0524
Toxoplasma gondii transporter, cation channel family protein 0.0286 0.1544 1
Leishmania major pyruvate kinase 0.0033 0.0079 0.0178
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.023 0.0514
Mycobacterium ulcerans acyl-CoA synthetase 0.0083 0.0366 0.071
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0075 0.0322 0.6107
Mycobacterium leprae Probable lipase LipE 0.0073 0.0311 0.065
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0012 0.0027
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0075 0.0319 0.0668
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0079 0.0343 0.0331
Echinococcus multilocularis voltage dependent calcium channel 0.0852 0.4824 0.4818
Echinococcus granulosus cpg binding protein 0.0065 0.0266 0.0254
Loa Loa (eye worm) hypothetical protein 0.0023 0.0021 0.0017
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0075 0.0322 0.0675
Schistosoma mansoni voltage-gated potassium channel 0.0035 0.0086 0.0074
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0035 0.0086 0.0151
Brugia malayi Methyltransferase-like protein 4 0.0022 0.0017 0.0009
Leishmania major importin beta-1 subunit, putative 0.0024 0.0025 0.0057
Echinococcus multilocularis short transient receptor potential channel 6 0.0035 0.0086 0.0074
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0311 0.9634
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0101 0.0181
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0035 0.0086 0.0074
Schistosoma mansoni methyltransferase-related 0.0022 0.0017 0.0004
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0051 0.0079
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0035 0.0086 0.0151
Brugia malayi beta-lactamase 0.0073 0.0311 0.0611
Echinococcus granulosus potassium large conductance calcium activated 0.0035 0.0086 0.0074
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.008 0.0139
Loa Loa (eye worm) hypothetical protein 0.0035 0.0086 0.0151
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0035 0.0086 0.0074
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0109 0.052 0.0508
Trypanosoma cruzi ISWI complex protein 0.0034 0.0081 0.0179
Schistosoma mansoni methyl-cpg binding protein mbd 0.0037 0.0103 0.0091
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0113 0.0539 0.0527
Echinococcus multilocularis potassium voltage gated channel protein 0.0035 0.0086 0.0074
Schistosoma mansoni calcium-activated potassium channel 0.0035 0.0086 0.0074
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0083 0.0366 0.071
Schistosoma mansoni hypothetical protein 0.0112 0.0536 0.0524
Echinococcus multilocularis microtubule associated protein 2 0.0671 0.3774 0.3766
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0097 0.0553
Schistosoma mansoni bromodomain containing protein 0.0142 0.071 0.0699
Trichomonas vaginalis chaperonin, putative 0.0024 0.0023 0.033
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0039 0.0111 0.0098
Echinococcus granulosus hyperpolarization activated cyclic 0.0035 0.0086 0.0074
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0079 0.0175
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0079 0.0231
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0101 0.0167
Echinococcus multilocularis lysosomal alpha glucosidase 0.0164 0.0836 0.0825
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.008 0.0139
Loa Loa (eye worm) hypothetical protein 0.0035 0.0086 0.0151
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0033 0.008 0.0139
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0049 0.0172 0.0314
Echinococcus granulosus importin subunit beta 1 0.003 0.0058 0.0045
Echinococcus multilocularis potassium voltage gated channel protein 0.0035 0.0086 0.0074
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0033 0.008 0.0068
Brugia malayi beta-lactamase family protein 0.0073 0.0311 0.0611
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0029 0.0055 0.0124
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0123 0.0599 0.0587
Loa Loa (eye worm) hypothetical protein 0.0023 0.002 0.0016
Echinococcus multilocularis transfer RNA-Gly 0.0035 0.0086 0.0074
Schistosoma mansoni voltage-gated potassium channel 0.0035 0.0086 0.0074
Echinococcus granulosus serine protein kinase ATM 0.0027 0.0042 0.003
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0354 0.1939 0.3941
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0035 0.0086 0.0074
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0075 0.0322 0.0687
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0035 0.0086 0.0074
Leishmania major hypothetical protein, conserved 0.0034 0.0081 0.0181
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0079 0.1071
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0112 0.0533 0.1161
Schistosoma mansoni hypothetical protein 0.0034 0.0081 0.0069
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0311 0.9634
Schistosoma mansoni voltage-gated potassium channel 0.0035 0.0086 0.0074
Brugia malayi jmjC domain containing protein 0.0093 0.0426 0.0846
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.0311 0.0662
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0097 0.2734
Toxoplasma gondii propionate-CoA ligase 0.0075 0.0322 0.2023
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0075 0.0319 0.0614
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0035 0.0086 0.0151
Mycobacterium ulcerans thioesterase 0.0062 0.0247 0.0466
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0427 0.236 0.4802
Echinococcus granulosus histone lysine methyltransferase setb 0.0039 0.0111 0.0098
Loa Loa (eye worm) hypothetical protein 0.0035 0.0086 0.0151
Brugia malayi Flap endonuclease-1 0.0029 0.0055 0.0087
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0072 0.0306 0.065
Loa Loa (eye worm) hypothetical protein 0.0075 0.0321 0.0632
Entamoeba histolytica acyl-CoA synthetase, putative 0.0075 0.0322 0.6107
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0027 0.0042 0.0174
Brugia malayi beta-lactamase family protein 0.0073 0.0311 0.0611
Loa Loa (eye worm) hypothetical protein 0.003 0.0058 0.0093
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0075 0.0319 0.068
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0075 0.0322 0.0712
Schistosoma mansoni thyroid hormone receptor 0.0033 0.008 0.0068
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0075 0.0322 0.2023
Brugia malayi Bromodomain containing protein 0.0034 0.0081 0.0141
Schistosoma mansoni smad1 5 8 and 0.0026 0.0034 0.0022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0033 0.008 0.0139
Echinococcus granulosus potassium voltage gated channel protein 0.0035 0.0086 0.0074
Toxoplasma gondii hypothetical protein 0.0035 0.0086 0.0482
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0101 0.1416
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0033 0.008 0.0139
Schistosoma mansoni 60S ribosomal protein L21 0.0035 0.0086 0.0074
Loa Loa (eye worm) hypothetical protein 0.0035 0.0086 0.0151
Schistosoma mansoni hypothetical protein 0.0045 0.0149 0.0137
Leishmania major 4-coumarate:coa ligase-like protein 0.0075 0.0322 0.0722
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0164 0.0311
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0097 0.2734
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0079 0.0346 0.0669
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0083 0.0366 0.0785
Schistosoma mansoni voltage-gated potassium channel 0.0035 0.0086 0.0074
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0058 0.0223 0.0211
Loa Loa (eye worm) hypothetical protein 0.0075 0.0322 0.0634
Mycobacterium ulcerans acyl-CoA synthetase 0.0075 0.0322 0.0621
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0027 0.0042 0.0093
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.008 0.0139
Schistosoma mansoni smad 0.0026 0.0034 0.0022
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0079 0.0123
Brugia malayi AMP-binding enzyme family protein 0.0075 0.0322 0.0634
Echinococcus granulosus voltage gated potassium channel 0.0035 0.0086 0.0074
Loa Loa (eye worm) hypothetical protein 0.0035 0.0086 0.0151
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0035 0.0086 0.0074
Mycobacterium ulcerans acyl-CoA synthetase 0.0075 0.0322 0.0621
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0033 0.008 0.0139
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0024 0.0023 0.0164
Entamoeba histolytica hypothetical protein 0.0027 0.0042 0.0587
Brugia malayi nuclear hormone receptor 0.0033 0.008 0.0139
Echinococcus multilocularis GPCR, family 2 0.0112 0.0536 0.0524
Chlamydia trachomatis pyruvate kinase 0.0033 0.0079 0.5
Brugia malayi mbt repeat family protein 0.0048 0.0164 0.0311
Mycobacterium leprae Polyketide synthase Pks13 0.0112 0.0533 0.115
Schistosoma mansoni hypothetical protein 0.0316 0.1716 0.1706
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.006 0.0234 0.0441
Echinococcus granulosus snurportin 1 0.0316 0.1716 0.1706
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0079 0.0391
Echinococcus granulosus potassium voltage gated channel protein 0.0035 0.0086 0.0074
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0075 0.0319 0.068
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.006 0.0234 0.0478
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0083 0.0366 0.0774
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.0311 0.0662
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0075 0.0319 0.0627
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0097 0.0173
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0026 0.0034 0.0022
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0311 0.0299
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0101 0.0226
Mycobacterium ulcerans polyketide synthase Pks13 0.0112 0.0533 0.1052
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0075 0.0322 0.0621
Echinococcus multilocularis calcium activated potassium channel 0.0035 0.0086 0.0074
Loa Loa (eye worm) hypothetical protein 0.0033 0.008 0.0139
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.0311 0.0662
Loa Loa (eye worm) hypothetical protein 0.0852 0.4824 0.9843
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0311 0.9634
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0035 0.0086 0.0074
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0079 0.0137
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0035 0.0086 0.0074
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0035 0.0086 0.0074
Plasmodium falciparum flap endonuclease 1 0.0029 0.0055 0.0684
Loa Loa (eye worm) hypothetical protein 0.0035 0.0086 0.0151
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0033 0.008 0.0068
Schistosoma mansoni pyruvate kinase 0.0033 0.0079 0.0067
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0053 0.0192 0.018
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0035 0.0086 0.0074
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0035 0.0086 0.0074
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0035 0.0086 0.0074
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0033 0.008 0.0139
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.0801 0.4526 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0083 0.0366 0.0723
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0033 0.008 0.0068
Brugia malayi olfactory channel protein osm-9 0.0035 0.0086 0.0151
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0079 0.0346 0.0729
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0852 0.4824 0.4818
Brugia malayi AMP-binding enzyme family protein 0.0075 0.0322 0.0634
Echinococcus multilocularis serine protein kinase ATM 0.0027 0.0042 0.003
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0035 0.0086 0.0151
Schistosoma mansoni voltage-gated potassium channel 0.0035 0.0086 0.0074
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0112 0.0536 0.1071
Schistosoma mansoni hypothetical protein 0.0112 0.0536 0.0524
Toxoplasma gondii type I fatty acid synthase, putative 0.009 0.0406 0.2572
Echinococcus multilocularis transient receptor potential cation channel 0.0035 0.0086 0.0074
Loa Loa (eye worm) hypothetical protein 0.0089 0.0405 0.0802
Brugia malayi Muscleblind-like protein 0.0307 0.1665 0.338
Echinococcus granulosus potassium voltage gated channel protein 0.0035 0.0086 0.0074
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0051 0.0619
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0035 0.0086 0.0482
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0035 0.0086 0.0074
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0033 0.008 0.0068
Entamoeba histolytica hypothetical protein 0.0024 0.0025 0.0253
Brugia malayi Steroid receptor seven-up type 2 0.0033 0.008 0.0139
Echinococcus multilocularis short transient receptor potential channel 6 0.0035 0.0086 0.0074
Echinococcus granulosus pyruvate kinase 0.0033 0.0079 0.0067
Echinococcus granulosus voltage gated potassium channel 0.0035 0.0086 0.0074
Loa Loa (eye worm) ryanodine receptor 0.0035 0.0086 0.0151
Entamoeba histolytica hypothetical protein 0.0109 0.052 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0101 1
Brugia malayi mbt repeat family protein 0.0048 0.0164 0.0311
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0097 0.2734
Leishmania major GTP-binding protein, putative 0.0022 0.0012 0.0028
Echinococcus granulosus GPCR family 2 0.0112 0.0536 0.0524
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0079 0.0141
Echinococcus granulosus transient receptor potential cation channel 0.0035 0.0086 0.0074
Leishmania major hypothetical protein, unknown function 0.0035 0.0086 0.0193
Brugia malayi Calcitonin receptor-like protein seb-1 0.0354 0.1939 0.3941
Echinococcus granulosus short transient receptor potential channel 6 0.0035 0.0086 0.0074
Schistosoma mansoni voltage-gated potassium channel 0.0035 0.0086 0.0074
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.008 0.0068
Loa Loa (eye worm) oxidoreductase 0.0075 0.0322 0.0634
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0164 0.0152
Loa Loa (eye worm) hypothetical protein 0.0033 0.008 0.0139
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0164 0.093
Echinococcus multilocularis pyruvate kinase 0.0026 0.0039 0.0026
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.023 0.1417
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0311 0.0687
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0427 0.236 0.4802
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0025 0.0414
Plasmodium vivax importin-beta 2, putative 0.003 0.0058 0.0724
Mycobacterium ulcerans beta-lactamase 0.0073 0.0311 0.0597
Schistosoma mansoni ryanodine receptor related 0.0035 0.0086 0.0074
Loa Loa (eye worm) steroid hormone receptor 0.0033 0.008 0.0139
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0024 0.0023 0.001
Toxoplasma gondii histone lysine methyltransferase SET1 0.0115 0.0553 0.3529
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0058 0.0295
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0024 0.0023 0.001
Trichomonas vaginalis flap endonuclease-1, putative 0.0029 0.0055 0.1379
Onchocerca volvulus Huntingtin homolog 0.0239 0.1271 1
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0075 0.0322 0.0687
Loa Loa (eye worm) MH2 domain-containing protein 0.0375 0.2061 0.419
Loa Loa (eye worm) hypothetical protein 0.0039 0.0111 0.0201
Mycobacterium ulcerans acyl-CoA synthetase 0.0075 0.0322 0.0621
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0075 0.0322 0.031
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.0311 0.0662
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0029 0.0055 0.025
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0203 0.0191
Schistosoma mansoni hypothetical protein 0.0299 0.1621 0.161
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0134 0.0665 0.0653
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0197 0.1026 0.1015
Echinococcus multilocularis transient receptor potential cation channel 0.0035 0.0086 0.0074
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0134 0.0665 0.0653
Echinococcus multilocularis transient receptor potential cation channel 0.0035 0.0086 0.0074
Brugia malayi T-complex protein 1, beta subunit 0.0024 0.0023 0.0021
Brugia malayi hypothetical protein 0.013 0.0637 0.1278
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0024 0.0023 0.005
Schistosoma mansoni voltage-gated potassium channel 0.0035 0.0086 0.0074
Brugia malayi cation channel family protein 0.0035 0.0086 0.0151
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0035 0.0086 0.0289
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.023 0.0479
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0035 0.0086 0.0289
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0033 0.008 0.0068
Mycobacterium ulcerans thioesterase TesA 0.0062 0.0247 0.0466
Echinococcus granulosus methyl CpG binding domain protein 2 0.0037 0.0103 0.0091
Entamoeba histolytica hypothetical protein 0.0109 0.052 1
Echinococcus granulosus microtubule associated protein 2 0.0671 0.3774 0.3766
Echinococcus multilocularis muscleblind protein 1 0.0307 0.1665 0.1654
Brugia malayi MH1 domain containing protein 0.0026 0.0034 0.0045
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0027 0.0042 0.0061
Entamoeba histolytica hypothetical protein 0.0109 0.052 1
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0035 0.0086 0.0074
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.008 0.0139
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0033 0.008 0.0068
Schistosoma mansoni voltage-gated potassium channel 0.0035 0.0086 0.0074
Echinococcus granulosus transient receptor potential cation channel 0.0035 0.0086 0.0074
Giardia lamblia Flap structure-specific endonuclease 0.0029 0.0055 0.4832
Schistosoma mansoni voltage-gated potassium channel 0.0035 0.0086 0.0074
Giardia lamblia Pyruvate kinase 0.0033 0.0079 0.7561
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0021 0.0017
Loa Loa (eye worm) latrophilin receptor protein 2 0.0112 0.0536 0.1071
Loa Loa (eye worm) hypothetical protein 0.0033 0.0079 0.0137
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.008 0.0139
Mycobacterium ulcerans Type I modular polyketide synthase 0.0075 0.0319 0.0614
Mycobacterium tuberculosis Probable thioesterase TesA 0.0062 0.0247 0.0518
Echinococcus granulosus transient receptor potential cation channel 0.0035 0.0086 0.0074
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0075 0.0321 0.9969
Onchocerca volvulus 0.0073 0.0311 0.2131
Schistosoma mansoni voltage-gated cation channel 0.0852 0.4824 0.4818
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0051 0.0039
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0097 0.2734
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0035 0.0086 0.0074
Schistosoma mansoni alpha-glucosidase 0.0141 0.0704 0.0693
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.0426 0.0414
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0113 0.0539 0.0527
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0222 0.0429
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0053 0.0192 0.018
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0075 0.0319 0.0668
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0035 0.0086 0.0074
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0427 0.236 0.2351
Loa Loa (eye worm) hypothetical protein 0.0035 0.0086 0.0151
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0113 0.0539 0.0527
Echinococcus granulosus potassium voltage gated channel protein 0.0035 0.0086 0.0074
Plasmodium falciparum ataxin-2 like protein, putative 0.013 0.0637 1
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0101 0.0181
Schistosoma mansoni transient receptor potential channel 0.0035 0.0086 0.0074
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.0311 0.0611
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0035 0.0086 0.0074
Schistosoma mansoni vesicular amine transporter 0.0035 0.0086 0.0074
Echinococcus multilocularis snurportin 1 0.0316 0.1716 0.1706
Loa Loa (eye worm) hypothetical protein 0.0073 0.0311 0.0611
Loa Loa (eye worm) hypothetical protein 0.0252 0.1344 0.2724
Trichomonas vaginalis antibiotic synthetase, putative 0.0075 0.0322 1
Loa Loa (eye worm) hypothetical protein 0.0136 0.0674 0.1353
Loa Loa (eye worm) flap endonuclease-1 0.0029 0.0055 0.0087
Loa Loa (eye worm) MBCTL1 0.0055 0.0203 0.039
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0075 0.0322 0.031
Mycobacterium leprae conserved hypothetical protein 0.0073 0.0311 0.065
Schistosoma mansoni hypothetical protein 0.0058 0.0223 0.0211
Echinococcus multilocularis transient receptor potential cation channel 0.0035 0.0086 0.0074
Loa Loa (eye worm) ion channel NompC 0.0035 0.0086 0.0151
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0075 0.0322 0.0687
Echinococcus multilocularis voltage gated potassium channel 0.0035 0.0086 0.0074
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0164 0.0152
Echinococcus multilocularis potassium large conductance calcium activated 0.0035 0.0086 0.0074
Brugia malayi MH2 domain containing protein 0.0026 0.0034 0.0045
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0852 0.4824 0.4818
Schistosoma mansoni hypothetical protein 0.0112 0.0536 0.0524
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0075 0.0322 0.2023
Schistosoma mansoni coup transcription factor 0.0033 0.008 0.0068
Trypanosoma cruzi PAB1-binding protein , putative 0.013 0.0637 0.1407
Echinococcus multilocularis dnaJ subfamily B 0.0826 0.4672 0.4666
Loa Loa (eye worm) voltage-dependent calcium channel 0.0286 0.1544 0.3134
Loa Loa (eye worm) bromodomain containing protein 0.0039 0.0111 0.0202
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0058 0.0265
Echinococcus multilocularis long chain fatty acid transport protein 4 0.0801 0.4526 0.4519
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0033 0.008 0.0139

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.9953 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Saccharomyces cerevisiae ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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