Detailed information for compound 168219

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 692.8 | Formula: C40H44N4O7
  • H donors: 1 H acceptors: 6 LogP: 5.05 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(=O)C1CCCN1C(=O)[C@H]1Cc2ccccc2CN1C(=O)[C@H]1CC[C@H](N1C(=O)[C@H]1Cc2c(N1C(=O)OC(C)(C)C)cccc2)c1ccccc1
  • InChi: 1S/C40H44N4O7/c1-40(2,3)51-39(50)44-29-17-10-9-15-27(29)23-34(44)37(47)43-30(25-12-5-4-6-13-25)19-20-31(43)35(45)42-24-28-16-8-7-14-26(28)22-33(42)36(46)41-21-11-18-32(41)38(48)49/h4-10,12-17,30-34H,11,18-24H2,1-3H3,(H,48,49)/t30-,31+,32?,33+,34+/m0/s1
  • InChiKey: HZGJNOIOQNCQTF-FUJCLPHHSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Cholecystokinin B receptor Starlite/ChEMBL No references
Rattus norvegicus Cholecystokinin A receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi sulfakinin receptor protein Get druggable targets OG5_132882 All targets in OG5_132882
Brugia malayi hypothetical protein Get druggable targets OG5_132882 All targets in OG5_132882
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132882 All targets in OG5_132882
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Cholecystokinin A receptor   444 aa 385 aa 28.6 %
Echinococcus granulosus orexin receptor type 2 Cholecystokinin A receptor   444 aa 366 aa 23.5 %
Schistosoma japonicum FMRFamide receptor, putative Cholecystokinin A receptor   444 aa 363 aa 21.2 %
Schistosoma mansoni rhodopsin-like orphan GPCR Cholecystokinin A receptor   444 aa 380 aa 24.2 %
Schistosoma mansoni amine GPCR Cholecystokinin A receptor   444 aa 412 aa 26.2 %
Echinococcus multilocularis g protein coupled receptor Cholecystokinin A receptor   444 aa 403 aa 24.1 %
Echinococcus granulosus g protein coupled receptor Cholecystokinin A receptor   444 aa 399 aa 23.3 %
Echinococcus multilocularis orexin receptor type 2 Cholecystokinin A receptor   444 aa 362 aa 22.4 %
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor Cholecystokinin A receptor   444 aa 383 aa 21.7 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Cholecystokinin A receptor   444 aa 364 aa 28.6 %
Loa Loa (eye worm) hypothetical protein Cholecystokinin B receptor   452 aa 389 aa 31.4 %
Schistosoma mansoni biogenic amine (5HT) receptor Cholecystokinin A receptor   444 aa 362 aa 28.2 %
Echinococcus multilocularis neuropeptides capa receptor Cholecystokinin A receptor   444 aa 400 aa 21.0 %
Echinococcus granulosus g protein coupled receptor Cholecystokinin A receptor   444 aa 396 aa 23.5 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Cholecystokinin A receptor   444 aa 379 aa 24.8 %
Echinococcus multilocularis g protein coupled receptor Cholecystokinin A receptor   444 aa 396 aa 23.2 %
Echinococcus multilocularis serotonin receptor Cholecystokinin A receptor   444 aa 468 aa 22.4 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Cholecystokinin A receptor   444 aa 395 aa 24.6 %
Echinococcus granulosus rhodopsin orphan GPCR Cholecystokinin A receptor   444 aa 363 aa 19.6 %
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Cholecystokinin A receptor   444 aa 374 aa 24.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0032 0.0157 0.0156
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0032 0.0157 0.0156
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0041 0.0233 0.0233
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0032 0.0157 0.0157
Trypanosoma brucei sterol 24-c-methyltransferase, putative 0.0385 0.3017 0.3214
Onchocerca volvulus 0.0032 0.0157 0.0417
Loa Loa (eye worm) hypothetical protein 0.0032 0.0157 0.0157
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0032 0.0157 0.0156
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0291 0.2255 0.2411
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0032 0.0157 0.0157
Onchocerca volvulus 0.0032 0.0157 0.0417
Echinococcus multilocularis lamin b receptor 0.0096 0.068 0.068
Brugia malayi mbt repeat family protein 0.0047 0.0285 0.0284
Trypanosoma brucei cytochrome P450, putative 0.0023 0.0084 0.0074
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0198 0.0528
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0338 0.0338
Schistosoma mansoni vesicular acetylcholine transporter 0.0214 0.1631 0.163
Brugia malayi hypothetical protein 0.0269 0.2077 0.2077
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0084 0.009
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0032 0.0157 0.0157
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0032 0.0157 0.0157
Onchocerca volvulus 0.0032 0.0157 0.0417
Schistosoma mansoni cpg binding protein 0.0061 0.0393 0.0392
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.0395 0.0395
Schistosoma mansoni hypothetical protein 0.0015 0.0024 0.0024
Onchocerca volvulus 0.0047 0.0285 0.0759
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0032 0.0157 0.0157
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0024 0.0024
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0032 0.0157 0.0157
Onchocerca volvulus 0.0012 0 0.0001
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0166 0.1246 1
Echinococcus granulosus vesicular acetylcholine transporter 0.0214 0.1631 0.1631
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.0084 0.1842
Onchocerca volvulus 0.0012 0 0.0001
Brugia malayi Cytochrome P450 family protein 0.0052 0.0325 0.0324
Loa Loa (eye worm) hypothetical protein 0.005 0.0306 0.0306
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.0395 0.0395
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0032 0.0157 0.0156
Trichomonas vaginalis pten, drome, putative 0.0032 0.0157 0.0417
Brugia malayi Protein-tyrosine phosphatase 0.0032 0.0157 0.0156
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.1247 1 1
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0041 0.0233 0.0621
Onchocerca volvulus 0.0012 0 0.0001
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0057 0.0045
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0032 0.0157 0.0157
Entamoeba histolytica Pten 3-phosphoinositide phosphatase, putative 0.0032 0.0157 0.2289
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0006 0.0016
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0291 0.029
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0006 0.0016
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0041 0.0233 0.0233
Loa Loa (eye worm) hypothetical protein 0.0032 0.0157 0.0157
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0041 0.0233 0.0233
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0032 0.0157 0.0157
Brugia malayi Pre-SET motif family protein 0.0418 0.3287 0.3287
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0206 0.8473
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0418 0.3287 0.3287
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.039 0.0389
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0395 0.0395
Schistosoma mansoni protein tyrosine phosphatase 0.0032 0.0157 0.0156
Onchocerca volvulus 0.0032 0.0157 0.0417
Loa Loa (eye worm) hypothetical protein 0.0032 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0032 0.0157 0.0157
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.006 0.006
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0198 0.3247
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0024 0.0024
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0032 0.0157 0.0156
Loa Loa (eye worm) hypothetical protein 0.0188 0.142 0.142
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.039 0.3043
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0032 0.0157 0.0157
Brugia malayi Inositol-1 0.0037 0.0198 0.0198
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.049 0.049
Brugia malayi mbt repeat family protein 0.0047 0.0285 0.0284
Mycobacterium ulcerans putative regulatory protein 0.0035 0.0184 0.4504
Schistosoma mansoni cpg binding protein 0.0061 0.0393 0.0392
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.0385 0.3017 0.3225
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0032 0.0157 0.0156
Brugia malayi hypothetical protein 0.0032 0.0157 0.0156
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0032 0.0157 0.0157
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0285 0.0284
Onchocerca volvulus 0.0012 0 0.0001
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0032 0.0157 0.0157
Schistosoma mansoni ap endonuclease 0.0019 0.0057 0.0057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0261 0.0261
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0032 0.0157 0.0156
Trypanosoma cruzi lanosterol synthase, putative 0.03 0.233 0.2491
Onchocerca volvulus 0.0032 0.0157 0.0417
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0014 0.0015 0.0016
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0291 0.0291
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0159 0.1185 0.1185
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0032 0.0157 0.0157
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0597 0.4733 0.4733
Onchocerca volvulus 0.0048 0.0291 0.0776
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0024 0.0024
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0198 0.0198
Loa Loa (eye worm) cytochrome P450 family protein 0.0052 0.0325 0.0325
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0167 0.1232
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0167 0.0167
Onchocerca volvulus 0.0032 0.0157 0.0417
Echinococcus multilocularis vesicular acetylcholine transporter 0.0214 0.1631 0.1631
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0032 0.0157 0.0157
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0034 0.0034
Schistosoma mansoni hypothetical protein 0.0015 0.0024 0.0024
Leishmania major geranylgeranyltransferase, putative 0.0041 0.0233 0.0249
Trypanosoma brucei Sterol methyltransferase, putative 0.0385 0.3017 0.3214
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0291 0.029
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0032 0.0157 0.0156
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0214 0.1631 0.4344
Entamoeba histolytica hypothetical protein 0.0073 0.049 1
Mycobacterium leprae Conserved hypothetical protein 0.0014 0.0015 0.0914
Brugia malayi hypothetical protein 0.0024 0.0098 0.0097
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0032 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0032 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0032 0.0157 0.0157
Onchocerca volvulus 0.0012 0 0.0001
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0032 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0032 0.0157 0.0157
Schistosoma mansoni hypothetical protein 0.0033 0.0167 0.0167
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0124 0.0906 0.0905
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0395 0.0395
Loa Loa (eye worm) hypothetical protein 0.0032 0.0157 0.0157
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0198 0.0212
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0057 0.0897
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0285 0.0285
Onchocerca volvulus 0.0012 0 0.0001
Echinococcus multilocularis dnaJ subfamily B 0.0395 0.3101 0.3101
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0041 0.0233 0.0621
Leishmania major sterol 24-c-methyltransferase, putative 0.0385 0.3017 0.3225
Onchocerca volvulus 0.0476 0.3753 1
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0291 0.2255 0.2411
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.0041 0.0233 0.0233
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0032 0.0157 0.0157
Leishmania major lanosterol synthase, putative 0.0259 0.1998 0.2136
Loa Loa (eye worm) hypoxia-induced factor 1 0.0146 0.1085 0.1085
Leishmania major C-14 sterol reductase, putative 0.0096 0.068 0.0727
Plasmodium falciparum geranylgeranyltransferase, putative 0.0041 0.0233 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0233 0.0233
Loa Loa (eye worm) cytochrome P450 0.0014 0.0015 0.0015
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0057 0.0153
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.014 0.1035 0.1035
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0234 0.0624
Brugia malayi isocitrate dehydrogenase 0.0015 0.0024 0.0024
Brugia malayi S-adenosyl-methionine cycloartenol-C24-methyltransferase 0.0188 0.142 0.1419
Giardia lamblia Prenyltransferase 0.0041 0.0233 1
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0041 0.0233 0.0621
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0032 0.0157 0.0157
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0024 0.0024
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0285 0.0285
Leishmania major cytochrome p450-like protein 0.0014 0.0015 0.0016
Loa Loa (eye worm) hypothetical protein 0.0024 0.0098 0.0098
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.1247 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0261 0.0261
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.0041 0.0233 1
Schistosoma mansoni hypothetical protein 0.0015 0.0024 0.0024
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0032 0.0157 0.0156
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0032 0.0157 0.0157
Schistosoma mansoni protein tyrosine phosphatase 0.0032 0.0157 0.0156
Entamoeba histolytica hypothetical protein 0.0073 0.049 1
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0024 0.001
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0024 0.0026
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0057 0.0057
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0233 0.0249
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0032 0.0157 0.2289
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0338 0.0338
Trypanosoma cruzi lanosterol synthase, putative 0.03 0.233 0.2491
Schistosoma mansoni cpg binding protein 0.0057 0.0366 0.0366
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0234 0.2692
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0062 0.0062
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0261 0.0261
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0006 0.0016
Trypanosoma cruzi protein farnesyltransferase, putative 0.0041 0.0233 0.0249
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0034 0.0034
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0084 0.0084
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0198 0.0212
Schistosoma mansoni Lamin B receptor (ERG24) 0.0096 0.068 0.068
Onchocerca volvulus 0.0032 0.0157 0.0417
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0032 0.0157 0.0157
Onchocerca volvulus 0.0032 0.0157 0.0417
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0032 0.0157 0.0157
Echinococcus granulosus cpg binding protein 0.0061 0.0393 0.0393
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0006 0.0016
Brugia malayi hypothetical protein 0.0159 0.1185 0.1185
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0057 0.0057
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0032 0.0157 0.0156
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0234 0.0234
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0198 0.4882
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0012 0 0.5
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0032 0.0157 0.0156
Loa Loa (eye worm) hypothetical protein 0.0032 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0032 0.0157 0.0157
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0032 0.0157 0.0157
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0041 0.0233 0.268
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0261 0.0261
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0041 0.0233 0.0621
Loa Loa (eye worm) hypothetical protein 0.0032 0.0157 0.0157
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.049 0.049
Echinococcus multilocularis cpg binding protein 0.0061 0.0393 0.0393
Loa Loa (eye worm) hypothetical protein 0.0032 0.0157 0.0157
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0041 0.0233 0.0233
Loa Loa (eye worm) hypothetical protein 0.0269 0.2077 0.2077
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0006 0.0016
Onchocerca volvulus 0.0032 0.0157 0.0417
Leishmania major hypothetical protein, conserved 0.0291 0.2255 0.2411
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.0385 0.3017 0.3225
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0057 0.0153
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0032 0.0157 0.0156
Echinococcus multilocularis 0.0032 0.0157 0.0157
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0032 0.0157 0.0157
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0261 0.0261
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0041 0.0233 0.0621
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0338 0.0338
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0041 0.0233 0.0621
Echinococcus granulosus single minded 2 0.0035 0.0184 0.0184
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0032 0.0157 0.0157
Schistosoma mansoni pcd6 interacting protein-related 0.0032 0.0157 0.0156
Schistosoma mansoni aryl hydrocarbon receptor 0.0047 0.0283 0.0283
Schistosoma mansoni hypothetical protein 0.0395 0.3101 0.3101
Toxoplasma gondii exonuclease III APE 0.0019 0.0057 0.0519
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0198 0.0528
Onchocerca volvulus 4.1 G protein, putative homolog 0.0032 0.0157 0.0417
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0032 0.0157 0.0156
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0184 0.0184
Brugia malayi hypothetical protein 0.0016 0.0028 0.0028
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.039 0.4606
Loa Loa (eye worm) hypothetical protein 0.0047 0.0285 0.0285
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0032 0.0157 0.0157
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.0041 0.0233 0.0233
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0032 0.0157 0.0167
Mycobacterium leprae putative cytochrome p450 0.0014 0.0015 0.0914
Loa Loa (eye worm) hypothetical protein 0.0032 0.0157 0.0157
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.049 0.049
Loa Loa (eye worm) hypothetical protein 0.0032 0.0157 0.0157
Plasmodium vivax geranylgeranyltransferase, putative 0.0041 0.0233 0.5635
Loa Loa (eye worm) hypothetical protein 0.0054 0.0338 0.0338
Onchocerca volvulus 0.0032 0.0157 0.0417
Brugia malayi Cytochrome P450 family protein 0.0023 0.0084 0.0084
Leishmania major sterol C-24 reductase, putative 0.005 0.0306 0.0327
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.0385 0.3017 0.3225
Schistosoma mansoni hypothetical protein 0.0015 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0015 0.0024 0.0024
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0041 0.0233 0.5635
Onchocerca volvulus 0.0032 0.0157 0.0417
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.0041 0.0233 0.0233
Brugia malayi Protein-tyrosine phosphatase 1 0.0032 0.0157 0.0156
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0234 0.0624
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0032 0.0157 0.0157
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0191 0.1446 0.1446
Schistosoma mansoni survival motor neuron protein 0.0048 0.0291 0.0291
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0034 0.0034
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0032 0.0157 0.0157
Brugia malayi hypothetical protein 0.0032 0.0157 0.0156
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0032 0.0157 0.0156
Loa Loa (eye worm) hypothetical protein 0.0032 0.0157 0.0157
Brugia malayi ERG2 and Sigma1 receptor like protein 0.1167 0.9355 0.9355
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0032 0.0157 0.0156
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0032 0.0157 0.0156
Onchocerca volvulus 0.0032 0.0157 0.0417
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0032 0.0157 0.0157
Onchocerca volvulus Neuropeptide F receptor homolog 0.0012 0 0.0001
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0024 0.0026
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0198 0.0196
Trypanosoma brucei sterol 24-c-methyltransferase, putative 0.0385 0.3017 0.3214
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0032 0.0157 0.0167
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0024 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0006 0.0016
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0032 0.0157 0.0156
Brugia malayi hypothetical protein 0.0032 0.0157 0.0156
Loa Loa (eye worm) protein-tyrosine phosphatase 0.1247 1 1
Giardia lamblia Protein tyrosine phosphatase 0.0032 0.0157 0.5643
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0057 0.5
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0057 0.0061
Giardia lamblia Rab geranylgeranyltransferase 0.0041 0.0233 1
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0041 0.0233 0.0233
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0032 0.0157 0.0157
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0032 0.0157 0.0157
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0338 0.0338
Trypanosoma cruzi C-14 sterol reductase, putative 0.0096 0.068 0.0727
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0032 0.0157 0.0157
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0806 0.6433 0.6433
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0041 0.0233 0.0621
Schistosoma mansoni protein tyrosine phosphatase 0.0032 0.0157 0.0156
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0032 0.0157 0.0156
Trypanosoma cruzi Emopamil binding protein, putative 0.0291 0.2255 0.2411
Trypanosoma brucei lanosterol synthase 0.03 0.233 0.2479
Entamoeba histolytica hypothetical protein 0.0073 0.049 1
Onchocerca volvulus 0.0032 0.0157 0.0417
Brugia malayi Pre-SET motif family protein 0.0061 0.0395 0.0395
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0024 0.0024
Brugia malayi PAS domain containing protein 0.0047 0.0283 0.0283
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0057 0.0343
Loa Loa (eye worm) hypothetical protein 0.0048 0.0291 0.0291
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0041 0.0233 0.0621
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0395 0.0395
Loa Loa (eye worm) hypothetical protein 0.0032 0.0157 0.0157
Trypanosoma cruzi sterol C-24 reductase, putative 0.005 0.0306 0.0327
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0237 0.1817 0.1817
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0198 1
Onchocerca volvulus 0.0012 0 0.0001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0261 0.0261
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0032 0.0157 0.0167
Trypanosoma brucei Emopamil binding protein, putative 0.0291 0.2255 0.2398
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0214 0.1631 0.1631
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0167 1
Brugia malayi Cytochrome P450 family protein 0.0014 0.0015 0.0015
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0198 0.2249
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0032 0.0157 0.0157
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0024 0.0109
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0041 0.0233 0.0233
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0032 0.0157 0.0156
Loa Loa (eye worm) hypothetical protein 0.0032 0.0157 0.0157
Onchocerca volvulus 0.0032 0.0157 0.0417
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0338 0.0338
Onchocerca volvulus 0.0032 0.0157 0.0417
Trypanosoma brucei sterol 24-c-methyltransferase, putative 0.0201 0.1526 0.1618
Echinococcus multilocularis 0.0014 0.0015 0.0015
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0032 0.0157 0.0156
Loa Loa (eye worm) acetyltransferase 0.014 0.1035 0.1035
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0395 0.0395
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0057 0.0061
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0198 0.0212
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0198 0.0198
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.039 0.039
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0234 0.2692
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.0041 0.0233 0.4056
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0032 0.0157 0.0157
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0032 0.0157 0.0157
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0006 0.0016
Echinococcus granulosus dnaJ subfamily B 0.0395 0.3101 0.3101
Trichomonas vaginalis helicase, putative 0.0013 0.0006 0.0016
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0098 0.3523
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0032 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0032 0.0157 0.0157
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0206 0.3437
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0041 0.0233 0.0233
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0041 0.0233 0.0621
Onchocerca volvulus 0.0012 0 0.0001
Schistosoma mansoni inositol monophosphatase 0.0037 0.0198 0.0198
Echinococcus multilocularis survival motor neuron protein 1 0.0237 0.1817 0.1817
Echinococcus granulosus GPCR family 2 0.0015 0.0024 0.0024
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0032 0.0157 0.0156
Leishmania major sterol 24-c-methyltransferase, putative 0.0385 0.3017 0.3225
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.0041 0.0233 0.0249
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.0041 0.0233 0.5635
Onchocerca volvulus 0.0035 0.0184 0.049
Onchocerca volvulus 0.0032 0.0157 0.0417
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0024 0.0024
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0032 0.0157 0.0157
Echinococcus granulosus histone acetyltransferase KAT2B 0.0136 0.1003 0.1003
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0285 0.0285
Onchocerca volvulus 0.0012 0 0.0001
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0015 0.0024 0.0072
Leishmania major 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0291 0.2255 0.2411
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0032 0.0157 0.0157
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0041 0.0233 1
Loa Loa (eye worm) MBCTL1 0.0054 0.0338 0.0338
Onchocerca volvulus 0.0012 0 0.0001
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0057 0.0057
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0032 0.0157 0.0156
Schistosoma mansoni hypothetical protein 0.0073 0.049 0.049
Trichomonas vaginalis set domain proteins, putative 0.0476 0.3753 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.039 1
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0032 0.0157 0.0157
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0057 0.0057
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0014 0.0015 0.0016
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.0041 0.0233 0.0233
Loa Loa (eye worm) hypothetical protein 0.0032 0.0157 0.0157
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0006 0.0016
Trypanosoma brucei C-14 sterol reductase, putative 0.0096 0.068 0.0712
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0098 0.0088
Onchocerca volvulus 0.0061 0.0395 0.1052
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0233 0.0249
Schistosoma mansoni single-minded 0.0047 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0032 0.0157 0.0157
Onchocerca volvulus 0.0012 0 0.0001
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0032 0.0157 0.0157
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.0041 0.0233 0.4056
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0032 0.0157 0.0157
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0006 0.0016
Onchocerca volvulus 0.0012 0 0.0001
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0032 0.0157 0.0157
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.039 0.0416
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.014 0.1035 0.1034
Leishmania major hypothetical protein, conserved 0.0024 0.0098 0.0104
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0285 0.0285
Loa Loa (eye worm) hypothetical protein 0.0032 0.0157 0.0157
Trypanosoma brucei protein tyrosine phosphatase 1 0.0032 0.0157 0.0151
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0006 0.0016
Loa Loa (eye worm) protein tyrosine phosphatase 0.0032 0.0157 0.0157
Echinococcus granulosus lamin b receptor 0.0096 0.068 0.068
Schistosoma mansoni ap endonuclease 0.0019 0.0057 0.0057
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0261 0.0261
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0006 0.0016
Brugia malayi hypothetical protein 0.0073 0.049 0.049
Schistosoma mansoni hypothetical protein 0.0048 0.0291 0.0291
Trypanosoma cruzi C-14 sterol reductase, putative 0.0096 0.068 0.0727
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0032 0.0157 0.2289
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0206 0.8716
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.0041 0.0233 0.0233
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0061 0.0395 0.0395
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0032 0.0157 0.0157
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0032 0.0157 0.0157
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0395 0.4671
Echinococcus granulosus survival motor neuron protein 1 0.0237 0.1817 0.1817
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0032 0.0157 0.0157
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0032 0.0157 0.0156
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0032 0.0157 0.0156
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0366 0.0366
Onchocerca volvulus 0.0032 0.0157 0.0417
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0032 0.0157 0.0157
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0014 0.0015 0.0016
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0006 0.0016
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0032 0.0157 0.0157
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0041 0.0233 0.0233
Loa Loa (eye worm) hypothetical protein 0.0032 0.0157 0.0157
Echinococcus granulosus protein tyrosine phosphatase n9 0.0032 0.0157 0.0157
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0024 0.0024
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0006 0.0016
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0034 0.0034
Echinococcus multilocularis hypothetical protein 0.0032 0.0157 0.0157
Onchocerca volvulus 0.0057 0.0366 0.0975
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0291 0.0291
Onchocerca volvulus 0.0032 0.0157 0.0417
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0285 0.0285
Onchocerca volvulus 0.0012 0 0.0001
Brugia malayi hypothetical protein 0.0237 0.1817 0.1817
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0041 0.0233 0.0233
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0032 0.0157 0.0156
Loa Loa (eye worm) hypothetical protein 0.0061 0.0395 0.0395
Loa Loa (eye worm) hypothetical protein 0.0032 0.0157 0.0157
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0098 0.1015
Onchocerca volvulus 0.0032 0.0157 0.0417
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0024 0.0024
Schistosoma mansoni hypothetical protein 0.0014 0.0015 0.0015
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0034 0.0034
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0006 0.0016
Loa Loa (eye worm) hypothetical protein 0.0032 0.0157 0.0157
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0098 0.1985
Leishmania major cytochrome p450-like protein 0.0014 0.0015 0.0016
Loa Loa (eye worm) inositol-1 0.0037 0.0198 0.0198
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0032 0.0157 0.0157
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0041 0.0233 0.0233
Loa Loa (eye worm) histone methyltransferase 0.002 0.0062 0.0062
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0024 0.0024
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0032 0.0157 0.0156
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0062 0.0062
Schistosoma mansoni inositol monophosphatase 0.0037 0.0198 0.0198
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0041 0.0233 0.268
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0084 0.0084
Onchocerca volvulus 0.0291 0.2255 0.6008
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0032 0.0157 0.0157
Echinococcus multilocularis GPCR, family 2 0.0015 0.0024 0.0024
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0032 0.0157 0.0157
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0184 0.0184
Onchocerca volvulus 0.0012 0 0.0001
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0057 0.1126
Brugia malayi cytochrome P450 0.0014 0.0015 0.0015
Brugia malayi acetyltransferase, GNAT family protein 0.014 0.1035 0.1034
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0024 0.0026
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0084 0.0084
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0098 0.0104
Onchocerca volvulus 0.0032 0.0157 0.0417
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0012 0 0.0001
Brugia malayi Cytochrome P450 family protein 0.0023 0.0084 0.0084
Brugia malayi hypoxia-induced factor 1 0.0146 0.1085 0.1085
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0057 0.1593
Loa Loa (eye worm) hypothetical protein 0.0033 0.0167 0.0167
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0057 0.0061
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0191 0.1446 0.1446
Leishmania major farnesyltransferase beta subunit 0.0041 0.0233 0.0249
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0032 0.0157 0.0157
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0014 0.0015 0.0016
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0338 0.0338
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0367 0.0367
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0285 0.0759
Onchocerca volvulus 0.0012 0 0.0001
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0559 0.443 0.443
Onchocerca volvulus 0.0012 0 0.0001
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0032 0.0157 0.0156
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.039 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0198 0.0528
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0032 0.0157 0.0156
Trypanosoma cruzi sterol C-24 reductase, putative 0.005 0.0306 0.0327
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.0041 0.0233 0.268
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0032 0.0157 0.0156
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0032 0.0157 0.0157
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0032 0.0157 0.0156
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0032 0.0157 0.0157
Leishmania major tyrosine specific protein phosphatase, putative 0.0032 0.0157 0.0167
Schistosoma mansoni hypothetical protein 0.0292 0.2268 0.2268
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0032 0.0157 0.0156
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0032 0.0157 0.0157
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.039 0.039
Trypanosoma cruzi Emopamil binding protein, putative 0.0291 0.2255 0.2411
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0006 0.0016
Loa Loa (eye worm) hypothetical protein 0.1167 0.9355 0.9355
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0032 0.0157 0.0157
Brugia malayi hypothetical protein 0.0032 0.0157 0.0156
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.039 1
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0041 0.0233 0.4056
Echinococcus granulosus cytochrome P450 2K1 0.0014 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0032 0.0157 0.0157
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0261 0.0261
Echinococcus granulosus tm gpcr rhodopsin 0.0559 0.443 0.443
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0032 0.0157 0.0156
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.039 0.0389
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0006 0.0016
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0032 0.0157 0.0156
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0024 0.0109
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0041 0.0233 0.0233
Leishmania major protein-tyrosine phosphatase 1-like protein 0.0032 0.0157 0.0167
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0032 0.0157 0.0156
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0098 0.3523
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0024 0.0024
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0032 0.0157 0.0156
Onchocerca volvulus 0.0012 0 0.0001
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0032 0.0157 0.0156
Schistosoma mansoni cytochrome P450 0.0014 0.0015 0.0015
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0032 0.0157 0.0157
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0032 0.0157 0.0156
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0285 0.0284
Plasmodium vivax SET domain protein, putative 0.0061 0.0395 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0115 0.0828 1
Trypanosoma cruzi protein farnesyltransferase, putative 0.0041 0.0233 0.0249
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0084 0.009
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.1247 1 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0157 0.0157
Trypanosoma brucei C-8 sterol isomerase, putative 0.1167 0.9355 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0024 0.0024
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0032 0.0157 0.0157
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0098 0.0104
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.0041 0.0233 0.0233
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0032 0.0157 0.0157
Onchocerca volvulus 0.0032 0.0157 0.0417
Brugia malayi vesicular acetylcholine transporter unc-17 0.0214 0.1631 0.163
Brugia malayi Protein-tyrosine phosphatase 0.0032 0.0157 0.0156
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0234 0.5661
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0285 0.0284
Onchocerca volvulus 0.0032 0.0157 0.0417
Trypanosoma cruzi C-8 sterol isomerase, putative 0.1167 0.9355 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0006 0.0016
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0024 0.0024
Leishmania major C-8 sterol isomerase-like protein 0.1167 0.9355 1
Entamoeba histolytica hypothetical protein 0.0073 0.049 1
Brugia malayi sulfakinin receptor protein 0.0269 0.2077 0.2077
Leishmania major cytochrome p450-like protein 0.0023 0.0084 0.009
Brugia malayi CXXC zinc finger family protein 0.0057 0.0366 0.0366
Brugia malayi hypothetical protein 0.0032 0.0157 0.0156
Onchocerca volvulus 0.0032 0.0157 0.0417
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0032 0.0157 0.0156
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0261 0.0261

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.25 nM Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain. ChEMBL. No reference
IC50 (binding) = 0.25 nM Tested for displacement of [125I]-CCK-8 from Gastrin/Cholecystokinin type B receptor in rat brain. ChEMBL. No reference
IC50 (binding) > 10000 nM Tested for displacement of [3H]-L-364,718 from Cholecystokinin type A receptor in rat pancreas. ChEMBL. No reference
IC50 (binding) > 10000 nM Tested for displacement of [3H]-L-364,718 from Cholecystokinin type A receptor in rat pancreas. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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