Detailed information for compound 1698590

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 862.911 | Formula: C46H54O16
  • H donors: 10 H acceptors: 12 LogP: 4.16 Rotable bonds: 19
    Rule of 5 violations (Lipinski): 4
  • SMILES: OC[C@H]1O[C@H](Oc2ccc(cc2c2cccc(c2)CC(=O)O)CCCCCCc2ccc(c(c2)c2cccc(c2)CC(=O)O)O[C@H]2O[C@H](CO)[C@H]([C@H]([C@@H]2O)O)O)[C@H]([C@@H]([C@@H]1O)O)O
  • InChi: 1S/C46H54O16/c47-23-35-39(53)41(55)43(57)45(61-35)59-33-15-13-25(19-31(33)29-11-5-9-27(17-29)21-37(49)50)7-3-1-2-4-8-26-14-16-34(60-46-44(58)42(56)40(54)36(24-48)62-46)32(20-26)30-12-6-10-28(18-30)22-38(51)52/h5-6,9-20,35-36,39-48,53-58H,1-4,7-8,21-24H2,(H,49,50)(H,51,52)/t35-,36-,39-,40-,41-,42-,43+,44+,45+,46+/m1/s1
  • InChiKey: RYWCQJDEHXJHRI-PDKFAMIPSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.004 0.0046 0.0061
Echinococcus granulosus poly adp ribose polymerase 2 0.1491 0.3796 0.5029
Onchocerca volvulus 0.0325 0.0783 0.3135
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.012 0.0472
Loa Loa (eye worm) hypothetical protein 0.004 0.0046 0.012
Loa Loa (eye worm) CXXC zinc finger family protein 0.0034 0.003 0.008
Trichomonas vaginalis conserved hypothetical protein 0.0226 0.0527 0.2111
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0038 0.0101
Onchocerca volvulus 0.0038 0.004 0.0144
Echinococcus granulosus rhodopsin orphan GPCR 0.0325 0.0783 0.1037
Giardia lamblia PHD finger protein 15 0.0029 0.0018 0.0061
Onchocerca volvulus 0.0325 0.0783 0.3135
Loa Loa (eye worm) follicle stimulating hormone receptor 0.1323 0.3361 0.8854
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0027 0.0013 0.001
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0086 0.0164 0.0357
Schistosoma mansoni neuropeptide receptor 0.0325 0.0783 0.1037
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0325 0.0783 0.1037
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.009 0.0174 0.0231
Trypanosoma brucei hypothetical protein, conserved 0.0062 0.0104 0.0245
Echinococcus granulosus biogenic amine 5HT receptor 0.0325 0.0783 0.1037
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0034 0.0029 0.0039
Echinococcus granulosus biogenic amine 5HT receptor 0.0325 0.0783 0.1037
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0038 0.0072
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0073 0.0132 0.0338
Loa Loa (eye worm) hypothetical protein 0.0325 0.0783 0.2063
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0126 0.0268 0.0356
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0071 0.0276
Echinococcus granulosus transcription factor Dp 1 0.0045 0.0059 0.0079
Plasmodium vivax peptide deformylase, putative 0.3893 1 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0325 0.0783 0.1037
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.0696 0.2793
Schistosoma mansoni inositol transporter 0.0037 0.0039 0.0052
Brugia malayi hypothetical protein 0.0325 0.0783 0.1708
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0027 0.0013 0.001
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.003 0.0019 0.0025
Loa Loa (eye worm) hypothetical protein 0.0325 0.0783 0.2063
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0043 0.0084
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0071 0.0276
Schistosoma mansoni hypothetical protein 0.026 0.0615 0.0814
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0046 0.0061
Echinococcus granulosus neuropeptide receptor 0.0325 0.0783 0.1037
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0062 0.0104 0.0409
Trypanosoma cruzi hypothetical protein, conserved 0.0062 0.0104 0.0245
Echinococcus multilocularis nibrin 0.0027 0.0011 0.0015
Schistosoma mansoni DNA ligase IV 0.0027 0.0011 0.0015
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0325 0.0783 0.1037
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0062 0.0104 0.0102
Loa Loa (eye worm) hypothetical protein 0.0038 0.004 0.0106
Onchocerca volvulus 0.0061 0.0101 0.0387
Brugia malayi hypothetical protein 0.0325 0.0783 0.1708
Trichomonas vaginalis conserved hypothetical protein 0.0226 0.0527 0.2111
Schistosoma mansoni sodium/solute symporter 0.0037 0.0039 0.0052
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0078 0.0144 0.0353
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0325 0.0783 0.1037
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.004 0.0046 0.0061
Brugia malayi hypoxia-induced factor 1 0.0327 0.0787 0.1717
Trichomonas vaginalis conserved hypothetical protein 0.0226 0.0527 0.2111
Schistosoma mansoni hypothetical protein 0.0382 0.0929 0.1232
Onchocerca volvulus Bile acid receptor homolog 0.004 0.0046 0.0166
Leishmania major cytochrome p450-like protein 0.0066 0.0113 0.0287
Loa Loa (eye worm) hypothetical protein 0.0325 0.0783 0.2063
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0062 0.0104 0.0138
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0027 0.0013 0.001
Loa Loa (eye worm) hypothetical protein 0.0354 0.0858 0.226
Loa Loa (eye worm) hypothetical protein 0.0023 0.0002 0.0006
Schistosoma mansoni hypothetical protein 0.0177 0.0399 0.0529
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0031 0.0022 0.003
Echinococcus granulosus peregrin 0.0029 0.0018 0.0023
Echinococcus multilocularis somatostatin receptor 0.0325 0.0783 0.1037
Toxoplasma gondii melibiase subfamily protein 0.01 0.0202 0.02
Brugia malayi hypothetical protein 0.0325 0.0783 0.1708
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0126 0.0268 0.1071
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0027 0.0011 0.0024
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.004 0.0045 0.0099
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0067 0.0116 0.0153
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0119 0.025 0.0248
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0083 0.0327
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0031 0.0023 0.0031
Schistosoma mansoni hypothetical protein 0.0201 0.0461 0.0611
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0104 0.0102
Loa Loa (eye worm) hypothetical protein 0.0325 0.0783 0.2063
Brugia malayi Steroid receptor seven-up type 2 0.004 0.0046 0.01
Loa Loa (eye worm) hypothetical protein 0.0339 0.0819 0.2157
Brugia malayi GH02984p 0.0339 0.0819 0.1786
Echinococcus multilocularis replication factor c subunit 1 0.0027 0.0011 0.0015
Brugia malayi hypothetical protein 0.0325 0.0783 0.1708
Treponema pallidum fructose-bisphosphate aldolase 0.0292 0.0696 0.0686
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0104 0.0102
Loa Loa (eye worm) hypothetical protein 0.0325 0.0783 0.2063
Schistosoma mansoni tar DNA-binding protein 0.045 0.1104 0.1463
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.004 0.0053
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0038 0.0036
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0386 0.0941 0.1247
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.004 0.0038
Loa Loa (eye worm) hypothetical protein 0.0449 0.1102 0.2904
Loa Loa (eye worm) TAR-binding protein 0.045 0.1104 0.2908
Echinococcus multilocularis dro:myosuppressin receptor 0.0325 0.0783 0.1037
Echinococcus multilocularis ecdysone induced protein 78C 0.004 0.0046 0.0061
Onchocerca volvulus 0.0146 0.032 0.1271
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0325 0.0783 0.1037
Brugia malayi beta-lactamase family protein 0.0038 0.004 0.0088
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0125 0.0265 0.0351
Schistosoma mansoni thyroid hormone receptor 0.03 0.0718 0.0951
Echinococcus multilocularis neuropeptides capa receptor 0.0325 0.0783 0.1037
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0092 0.0181 0.0448
Loa Loa (eye worm) hypothetical protein 0.0325 0.0783 0.2063
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0077 0.0141 0.0186
Loa Loa (eye worm) tnks protein 0.0226 0.0527 0.139
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.0305 0.0404
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0325 0.0783 0.1037
Echinococcus granulosus FTZ F1 alpha 0.004 0.0046 0.0061
Echinococcus granulosus neuropeptides capa receptor 0.0325 0.0783 0.1037
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0027 0.0013 0.001
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0029 0.0017 0.0017
Echinococcus granulosus cytoplasmic intermediate filament protein 0.003 0.0019 0.0025
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.004 0.0046 0.0061
Echinococcus granulosus neuropeptide receptor 0.0325 0.0783 0.1037
Echinococcus multilocularis serotonin receptor 0.0325 0.0783 0.1037
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.0069 0.0154
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0071 0.0277
Trypanosoma brucei Polypeptide deformylase 1 0.1485 0.378 0.9959
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0125 0.0265 0.0263
Trichomonas vaginalis PIKK family atypical protein kinase 0.0073 0.0132 0.0522
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0062 0.0104 0.0245
Onchocerca volvulus 0.0038 0.004 0.0144
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0046 0.0061
Trichomonas vaginalis guanylate cyclase, putative 0.0027 0.0013 0.0045
Brugia malayi hypothetical protein 0.0027 0.0011 0.0024
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.004 0.0077
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0018 0.0015
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.01 0.0202 0.0268
Brugia malayi PHD-finger family protein 0.0029 0.0018 0.0039
Schistosoma mansoni aldehyde dehydrogenase 0.0119 0.025 0.0332
Leishmania major protein kinase, putative 0.0029 0.0017 0.0035
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0126 0.0268 0.1071
Brugia malayi steroid hormone receptor 0.004 0.0046 0.01
Loa Loa (eye worm) hypothetical protein 0.0325 0.0783 0.2063
Loa Loa (eye worm) hypothetical protein 0.0325 0.0783 0.2063
Trypanosoma cruzi cytochrome P450, putative 0.0066 0.0113 0.0269
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0325 0.0783 0.1037
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0177 0.0399 0.0529
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0075 0.0137 0.0135
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.0305 0.0404
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0027 0.0013 0.001
Loa Loa (eye worm) TYRA-2 protein 0.0325 0.0783 0.2063
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0027 0.0013 0.0045
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0126 0.0268 0.0355
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0062 0.0104 0.0409
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0031 0.0022 0.003
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0037 0.0039 0.0052
Brugia malayi Pre-SET motif family protein 0.0865 0.2179 0.4752
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0022 0.0081
Brugia malayi MH2 domain containing protein 0.0727 0.182 0.3969
Onchocerca volvulus 0.0325 0.0783 0.3135
Toxoplasma gondii cytochrome p450 superfamily protein 0.0027 0.0013 0.001
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.01 0.0202 0.0268
Leishmania major hypothetical protein, conserved 0.0038 0.004 0.0095
Echinococcus granulosus geminin 0.0201 0.0461 0.0611
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0126 0.0268 0.1071
Loa Loa (eye worm) hypothetical protein 0.0325 0.0783 0.2063
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.004 0.0046 0.0061
Echinococcus granulosus netrin receptor unc 5 0.0031 0.0023 0.0031
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0103 0.0209 0.0831
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0325 0.0783 0.1708
Trichomonas vaginalis set domain proteins, putative 0.0985 0.2487 1
Onchocerca volvulus Tankyrase homolog 0.0226 0.0527 0.2104
Loa Loa (eye worm) hypothetical protein 0.0202 0.0465 0.1226
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0325 0.0783 0.1037
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1756 0.448 0.5936
Echinococcus multilocularis poly (ADP ribose) polymerase 0.0516 0.1275 0.1689
Toxoplasma gondii histone lysine methyltransferase SET1 0.0069 0.0121 0.0119
Brugia malayi Nuclear hormone receptor family member nhr-40 0.004 0.0046 0.01
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0126 0.0268 0.1071
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0062 0.0104 0.0138
Entamoeba histolytica hypothetical protein 0.0372 0.0904 0.1964
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0067 0.0116 0.0153
Schistosoma mansoni hypothetical protein 0.0027 0.0013 0.0017
Loa Loa (eye worm) steroid hormone receptor 0.004 0.0046 0.012
Onchocerca volvulus 0.0027 0.0011 0.0027
Brugia malayi hypothetical protein 0.007 0.0124 0.0271
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0125 0.0265 0.0351
Loa Loa (eye worm) Smad1 0.005 0.007 0.0185
Echinococcus multilocularis GPCR, family 2 0.0177 0.0399 0.0529
Echinococcus multilocularis neuropeptide receptor A26 0.1322 0.3358 0.4449
Loa Loa (eye worm) G-protein coupled receptor 0.0325 0.0783 0.2063
Echinococcus multilocularis tankyrase 0.0226 0.0527 0.0698
Brugia malayi hypothetical protein 0.0325 0.0783 0.1708
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0086 0.0164 0.065
Loa Loa (eye worm) hypothetical protein 0.0325 0.0783 0.2063
Mycobacterium ulcerans beta-lactamase 0.0038 0.004 0.0038
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0062 0.0104 0.0138
Loa Loa (eye worm) phosphatidylinositol 3 0.0031 0.0022 0.0059
Toxoplasma gondii ATPase, AAA family protein 0.0027 0.0011 0.0009
Brugia malayi F/Y-rich N-terminus family protein 0.0024 0.0006 0.0012
Brugia malayi Tnks protein 0.0226 0.0527 0.1151
Brugia malayi neuropeptide F receptor 0.0325 0.0783 0.1708
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0177 0.0399 0.0529
Brugia malayi G protein-coupled receptor 0.0325 0.0783 0.1708
Trichomonas vaginalis CMGC family protein kinase 0.0171 0.0384 0.1537
Loa Loa (eye worm) hypothetical protein 0.003 0.0019 0.0049
Echinococcus granulosus rhodopsin orphan GPCR 0.0325 0.0783 0.1037
Echinococcus multilocularis smad 0.005 0.007 0.0093
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0075 0.0137 0.0298
Loa Loa (eye worm) hypothetical protein 0.0382 0.0929 0.2449
Schistosoma mansoni glutamate receptor NMDA 0.0034 0.0029 0.0039
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0386 0.0941 0.2479
Brugia malayi Nuclear hormone receptor family member nhr-49 0.004 0.0046 0.01
Brugia malayi hypothetical protein 0.0372 0.0904 0.1972
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0046 0.01
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0386 0.0941 0.2052
Trichomonas vaginalis conserved hypothetical protein 0.0226 0.0527 0.2111
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0062 0.0104 0.0264
Schistosoma mansoni amine GPCR 0.0325 0.0783 0.1037
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0092 0.0181 0.0467
Echinococcus granulosus glutamate receptor 2 0.0034 0.0029 0.0039
Loa Loa (eye worm) hypothetical protein 0.0325 0.0783 0.2063
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0126 0.0268 0.1071
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0062 0.0104 0.0245
Schistosoma mansoni hypothetical protein 0.0201 0.0461 0.0611
Schistosoma mansoni smad1 5 8 and 0.005 0.007 0.0093
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0062 0.0104 0.0102
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.0305 0.0404
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0126 0.0268 0.1071
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0325 0.0783 0.1037
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.3893 1 1
Loa Loa (eye worm) transcription factor SMAD2 0.0727 0.182 0.4794
Echinococcus granulosus neuropeptide Y receptor 0.0325 0.0783 0.1037
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0292 0.0696 0.1511
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.3893 1 1
Plasmodium falciparum phosphodiesterase delta, putative 0.0062 0.0104 0.0102
Echinococcus granulosus tm gpcr rhodopsin 0.0325 0.0783 0.1037
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0171 0.0384 0.0986
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0027 0.0013 0.001
Brugia malayi Melatonin receptor type 1A 0.0325 0.0783 0.1708
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.01 0.0202 0.0268
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0095 0.0189 0.025
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.026 0.0615 0.0814
Schistosoma mansoni hypothetical protein 0.0073 0.0131 0.0173
Brugia malayi intermediate filament protein 0.0061 0.0101 0.0219
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0078 0.0144 0.0353
Schistosoma mansoni opsin-like receptor 0.0325 0.0783 0.1037
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0031 0.0023 0.0061
Echinococcus multilocularis transfer RNA-Lys 0.0078 0.0144 0.0191
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0038 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0011 0.0035
Brugia malayi Dopamine receptor 0.0325 0.0783 0.1708
Brugia malayi Intermediate filament tail domain containing protein 0.0061 0.0101 0.0219
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0095 0.0189 0.025
Onchocerca volvulus Protein ultraspiracle homolog 0.004 0.0046 0.0166
Loa Loa (eye worm) hypothetical protein 0.0325 0.0783 0.2063
Echinococcus granulosus nuclear factor of activated T cells 5 0.016 0.0356 0.0471
Echinococcus granulosus replication factor c subunit 1 0.0027 0.0011 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0011 0.0035
Loa Loa (eye worm) hypothetical protein 0.0325 0.0783 0.2063
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0027 0.0013 0.001
Plasmodium vivax phosphodiesterase gamma, putative 0.0062 0.0104 0.0102
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0037 0.0039 0.0052
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0062 0.0104 0.0138
Brugia malayi Cytochrome P450 family protein 0.0066 0.0113 0.0246
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0027 0.0013 0.0004
Echinococcus granulosus tankyrase 0.0226 0.0527 0.0698
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.004 0.0045 0.0119
Onchocerca volvulus 0.0038 0.004 0.0144
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0325 0.0783 0.1037
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0325 0.0783 0.1037
Brugia malayi Nuclear hormone receptor family member nhr-41 0.004 0.0046 0.01
Schistosoma mansoni Smad4 0.005 0.007 0.0093
Leishmania major protein kinase, putative 0.0029 0.0017 0.0035
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0325 0.0783 0.1037
Loa Loa (eye worm) hypothetical protein 0.0027 0.0011 0.0029
Echinococcus granulosus intermediate filament protein 0.0061 0.0101 0.0133
Brugia malayi Serotonin receptor 0.0325 0.0783 0.1708
Brugia malayi hypothetical protein 0.0325 0.0783 0.1708
Schistosoma mansoni nuclear hormone receptor 0.004 0.0046 0.0061
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0325 0.0783 0.1037
Schistosoma mansoni ankyrin 23/unc44 0.0031 0.0023 0.0031
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0027 0.0013 0.001
Plasmodium falciparum phd finger protein, putative 0.0029 0.0018 0.0015
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0126 0.0268 0.1071
Loa Loa (eye worm) MH1 domain-containing protein 0.005 0.007 0.0185
Loa Loa (eye worm) hypothetical protein 0.0029 0.0018 0.0047
Toxoplasma gondii hypothetical protein 0.0064 0.0107 0.0105
Echinococcus granulosus poly (ADP ribose) polymerase 0.0289 0.069 0.0915
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.004 0.0046 0.0166
Entamoeba histolytica hypothetical protein 0.0289 0.069 0.1498
Loa Loa (eye worm) hypothetical protein 0.0177 0.0399 0.1052
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0027 0.0013 0.001
Loa Loa (eye worm) hypothetical protein 0.0039 0.0043 0.0112
Schistosoma mansoni transcription factor LCR-F1 0.0372 0.0904 0.1198
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0325 0.0783 0.2063
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.004 0.0053
Loa Loa (eye worm) hypothetical protein 0.0027 0.0011 0.0029
Echinococcus multilocularis tar DNA binding protein 0.045 0.1104 0.1463
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0062 0.0104 0.0409
Echinococcus multilocularis fmrfamide receptor 0.0325 0.0783 0.1037
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0449 0.1102 0.11
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0104 0.0102
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.012 0.0472
Loa Loa (eye worm) hypothetical protein 0.0325 0.0783 0.2063
Mycobacterium leprae conserved hypothetical protein 0.0038 0.004 0.0038
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0126 0.0268 0.068
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0062 0.0104 0.0274
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0027 0.0013 0.001
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0027 0.0013 0.001
Onchocerca volvulus 0.007 0.0124 0.0483
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0069 0.0154
Echinococcus granulosus orexin receptor type 2 0.0325 0.0783 0.1037
Echinococcus granulosus allatostatin A receptor 0.0325 0.0783 0.1037
Loa Loa (eye worm) hypothetical protein 0.0027 0.0013 0.0035
Echinococcus multilocularis serotonin receptor 0.0325 0.0783 0.1037
Schistosoma mansoni neuropeptide receptor 0.0325 0.0783 0.1037
Echinococcus granulosus smad 0.005 0.007 0.0093
Loa Loa (eye worm) hypothetical protein 0.004 0.0046 0.012
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0126 0.0268 0.068
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0057 0.009 0.0088
Loa Loa (eye worm) nuclear factor I 0.0027 0.0013 0.0035
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0027 0.0013 0.0045
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0062 0.0104 0.0138
Trypanosoma brucei DNA repair protein, putative 0.0088 0.0171 0.0423
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0038 0.0101
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0027 0.0013 0.001
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0062 0.0104 0.0138
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0092 0.0181 0.0448
Echinococcus multilocularis Glycoside hydrolase, family 27 0.01 0.0202 0.0268
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0027 0.0013 0.0045
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0031 0.0023 0.0031
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0325 0.0783 0.1708
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0046 0.01
Schistosoma mansoni hypothetical protein 0.0283 0.0673 0.0892
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0325 0.0783 0.1037
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.1491 0.3796 1
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0075 0.0137 0.0135
Loa Loa (eye worm) hypothetical protein 0.0325 0.0783 0.2063
Brugia malayi latrophilin 2 splice variant baaae 0.0382 0.0929 0.2027
Schistosoma mansoni lipoxygenase 0.0126 0.0268 0.0355
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0027 0.0013 0.001
Loa Loa (eye worm) hypothetical protein 0.006 0.0098 0.0257
Echinococcus multilocularis rhodopsin orphan GPCR 0.0325 0.0783 0.1037
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0066 0.0113 0.0111
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0047 0.0062
Plasmodium vivax SET domain protein, putative 0.0125 0.0265 0.0263
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0027 0.0011 0.0009
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0386 0.0941 0.1247
Trypanosoma brucei Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.0088 0.0171 0.0423
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0171 0.0384 0.0986
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0104 0.0102
Echinococcus granulosus poly (ADP ribose) polymerase 0.0289 0.069 0.0915
Echinococcus multilocularis mothers against decapentaplegic 5 0.005 0.007 0.0093
Brugia malayi bHLH-PAS transcription factor 0.0078 0.0144 0.0315
Schistosoma mansoni hypothetical protein 0.0325 0.0783 0.1037
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0125 0.0265 0.0351
Schistosoma mansoni poly [ADP-ribose] polymerase 0.1491 0.3796 0.5029
Brugia malayi TAR-binding protein 0.045 0.1104 0.2408
Loa Loa (eye worm) hypothetical protein 0.0024 0.0004 0.0011
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0062 0.0104 0.0409
Echinococcus multilocularis G-protein coupled receptor, putative 0.0325 0.0783 0.1037
Loa Loa (eye worm) hypothetical protein 0.0325 0.0783 0.2063
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.0069 0.0067
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0126 0.0268 0.068
Onchocerca volvulus 0.0027 0.0013 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0073 0.0132 0.0522
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0038 0.0036
Loa Loa (eye worm) hypothetical protein 0.0027 0.0011 0.0029
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0037 0.0039 0.0052
Echinococcus multilocularis netrin receptor unc 5 0.0031 0.0023 0.0031
Leishmania major cytochrome p450-like protein 0.0027 0.0013 0.0022
Brugia malayi Tachykinin-like peptides receptor 99D 0.0325 0.0783 0.1708
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0325 0.0783 0.1037
Onchocerca volvulus Neuropeptide F receptor homolog 0.0325 0.0783 0.3135
Loa Loa (eye worm) hypothetical protein 0.0125 0.0265 0.0698
Schistosoma mansoni hypothetical protein 0.0177 0.0399 0.0529
Brugia malayi GnHR receptor homolog 0.0325 0.0783 0.1708
Loa Loa (eye worm) latrophilin receptor protein 2 0.0177 0.0399 0.1052
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0078 0.0144 0.0381
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0325 0.0783 0.1037
Entamoeba histolytica hypothetical protein 0.0372 0.0904 0.1964
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.004 0.0038
Echinococcus multilocularis nuclear factor of activated T cells 5 0.016 0.0356 0.0471
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0033 0.0044
Schistosoma mansoni opsin-like receptor 0.0325 0.0783 0.1037
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0038 0.0051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0022 0.0081
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0092 0.0181 0.0239
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0027 0.0013 0.0035
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0086 0.0164 0.065
Schistosoma mansoni neuropeptide f receptor 76f 0.0325 0.0783 0.1037
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0119 0.025 0.0652
Loa Loa (eye worm) hypothetical protein 0.0325 0.0783 0.2063
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0126 0.0268 0.1071
Loa Loa (eye worm) cytochrome P450 family protein 0.0066 0.0113 0.0297
Echinococcus multilocularis neuropeptide Y receptor 0.0325 0.0783 0.1037
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0241 0.0566 0.0564
Brugia malayi WGR domain containing protein 0.1491 0.3796 0.8279
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0027 0.0013 0.001
Brugia malayi WGR domain containing protein 0.1797 0.4585 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0004 0.0002
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.004 0.0038
Brugia malayi putative neuropeptide receptor NPR1 0.0325 0.0783 0.1708
Trypanosoma cruzi Peptide deformylase 2, putative 0.1485 0.378 0.9959
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0062 0.0104 0.0245
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0146 0.0578
Mycobacterium ulcerans aldehyde dehydrogenase 0.0119 0.025 0.0248
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0046 0.0061
Echinococcus granulosus Smad4 0.005 0.007 0.0093
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0171 0.0384 0.0382
Brugia malayi cytochrome P450 0.0027 0.0013 0.0028
Trichomonas vaginalis CMGC family protein kinase 0.0171 0.0384 0.1537
Loa Loa (eye worm) hypothetical protein 0.004 0.0046 0.012
Loa Loa (eye worm) hypothetical protein 0.0031 0.0023 0.0061
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0126 0.0268 0.1071
Brugia malayi Cytochrome P450 family protein 0.0066 0.0113 0.0246
Onchocerca volvulus 0.0325 0.0783 0.3135
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.0305 0.0404
Echinococcus granulosus mitogen activated protein kinase 3 0.0171 0.0384 0.0509
Echinococcus multilocularis aryl hydrocarbon receptor 0.0027 0.0013 0.0018
Loa Loa (eye worm) hypothetical protein 0.0031 0.0024 0.0063
Loa Loa (eye worm) hypothetical protein 0.0038 0.004 0.0106
Schistosoma mansoni biogenic amine receptor 0.0325 0.0783 0.1037
Echinococcus multilocularis lamin 0.0061 0.0101 0.0133
Trypanosoma cruzi cytochrome P450, putative 0.0066 0.0113 0.0269
Echinococcus granulosus X box binding protein 1 0.0283 0.0673 0.0892
Loa Loa (eye worm) hypothetical protein 0.004 0.0046 0.012
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0062 0.0104 0.0138
Onchocerca volvulus 0.0078 0.0144 0.0564
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0085 0.0332
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0062 0.0104 0.0138
Schistosoma mansoni growth hormone secretagogue receptor 0.0325 0.0783 0.1037
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0027 0.0013 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0107 0.0422
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0038 0.0145
Onchocerca volvulus 0.0325 0.0783 0.3135
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.004 0.0046 0.0061
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.004 0.0077
Echinococcus multilocularis g-protein coupled receptor 0.0325 0.0783 0.1037
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.014 0.0305 0.0804
Trypanosoma cruzi hypothetical protein, conserved 0.0062 0.0104 0.0245
Echinococcus granulosus lamin dm0 0.0061 0.0101 0.0133
Schistosoma mansoni jumonji domain containing protein 0.0076 0.0138 0.0183
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0126 0.0268 0.1071
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.0696 0.2793
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0038 0.009
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.0696 0.2793
Loa Loa (eye worm) hypothetical protein 0.0325 0.0783 0.2063
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.1485 0.378 0.9959
Schistosoma mansoni lipoxygenase 0.0088 0.017 0.0225
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0018 0.0015
Loa Loa (eye worm) hypothetical protein 0.0088 0.0171 0.0451
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0062 0.0104 0.0138
Treponema pallidum polypeptide deformylase (def) 0.3893 1 1
Schistosoma mansoni topbp1 0.0027 0.0011 0.0015
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0075 0.0137 0.0135
Schistosoma mansoni retinoic acid receptor RXR 0.004 0.0046 0.0061
Schistosoma mansoni neuropeptide F-like receptor 0.0325 0.0783 0.1037
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0062 0.0104 0.0138
Brugia malayi G-protein coupled receptor 0.0325 0.0783 0.1708
Onchocerca volvulus 0.0125 0.0265 0.1049
Schistosoma mansoni smad1 5 8 and 0.005 0.007 0.0093
Plasmodium vivax hypothetical protein, conserved 0.0038 0.004 0.0038
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0023 0.0001 0.0001
Plasmodium falciparum replication factor C subunit 1, putative 0.0027 0.0011 0.0009
Leishmania major hypothetical protein, conserved 0.0062 0.0104 0.0264
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0067 0.0116 0.0456
Onchocerca volvulus 0.0325 0.0783 0.3135
Schistosoma mansoni single-minded 0.0106 0.0215 0.0285
Schistosoma mansoni cytochrome P450 0.0027 0.0013 0.0017
Brugia malayi CXXC zinc finger family protein 0.0034 0.003 0.0066
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0027 0.0013 0.0024
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.026 0.0615 0.0814
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0126 0.0268 0.1071
Trypanosoma cruzi DNA repair protein, putative 0.0088 0.0171 0.0423
Echinococcus granulosus sodium:myo inositol cotransporter 0.0037 0.0039 0.0052
Brugia malayi putative neuropeptide receptor 0.0325 0.0783 0.1708
Echinococcus granulosus retinoic acid receptor rxr beta a 0.004 0.0046 0.0061
Onchocerca volvulus 0.0325 0.0783 0.3135
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0325 0.0783 0.1708
Onchocerca volvulus 0.0325 0.0783 0.3135
Echinococcus multilocularis poly (adp ribose) polymerase 2 0.1491 0.3796 0.5029
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0092 0.0181 0.0239
Schistosoma mansoni cpg binding protein 0.0034 0.003 0.004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0083 0.0327
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0325 0.0783 0.2063
Schistosoma mansoni amine GPCR 0.0325 0.0783 0.1037
Entamoeba histolytica hypothetical protein 0.0226 0.0527 0.1141
Giardia lamblia Fructose-bisphosphate aldolase 0.0292 0.0696 0.6279
Loa Loa (eye worm) hypoxia-induced factor 1 0.0327 0.0787 0.2074
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0126 0.0268 0.1071
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.004 0.0046 0.012
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0037 0.0039 0.0037
Schistosoma mansoni amine GPCR 0.0325 0.0783 0.1037
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.004 0.0046 0.0061
Schistosoma mansoni hypothetical protein 0.0031 0.0023 0.0031
Schistosoma mansoni smad1 5 8 and 0.005 0.007 0.0093
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0027 0.0013 0.0004
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.004 0.0152
Brugia malayi MH1 domain containing protein 0.0027 0.0013 0.0029
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.0696 0.2793
Echinococcus multilocularis g protein coupled receptor 0.0325 0.0783 0.1037
Trichomonas vaginalis conserved hypothetical protein 0.0226 0.0527 0.2111
Loa Loa (eye worm) hypothetical protein 0.0027 0.0011 0.0029
Schistosoma mansoni tar DNA-binding protein 0.045 0.1104 0.1463
Loa Loa (eye worm) hypothetical protein 0.0049 0.0069 0.0182
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.004 0.0038
Schistosoma mansoni coup transcription factor 0.004 0.0046 0.0061
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0104 0.0102
Brugia malayi small heat shock protein 0.0684 0.171 0.3729
Trypanosoma cruzi Peptide deformylase 2, putative 0.1485 0.378 0.9959
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0126 0.0268 0.1071
Schistosoma mansoni hypothetical protein 0.0372 0.0904 0.1198
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0062 0.0104 0.0138
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0104 0.0102
Toxoplasma gondii aldehyde dehydrogenase 0.0119 0.025 0.0248
Loa Loa (eye worm) hypothetical protein 0.0325 0.0783 0.2063
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0177 0.0401 0.0875
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0119 0.025 0.0332
Brugia malayi Nuclear hormone receptor family member nhr-1 0.004 0.0046 0.01
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.004 0.0046 0.0061
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0038 0.0072
Echinococcus multilocularis g protein coupled receptor 0.0325 0.0783 0.1037
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0027 0.0011 0.0035
Schistosoma mansoni hypothetical protein 0.0177 0.0401 0.0531
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0062 0.0104 0.0245
Brugia malayi Dopamine receptor protein 1 0.0325 0.0783 0.1708
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0013 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0011 0.0035
Onchocerca volvulus 0.0061 0.0101 0.0387
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0078 0.0144 0.0191
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0079 0.0147 0.0195
Loa Loa (eye worm) hypothetical protein 0.0325 0.0783 0.2063
Echinococcus granulosus tumor protein p63 0.1382 0.3514 0.4656
Schistosoma mansoni lamin 0.0061 0.0101 0.0133
Entamoeba histolytica poly(ADP-ribose) polymerase, putative 0.1797 0.4585 1
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0038 0.0051
Echinococcus multilocularis G protein coupled receptor 139 0.0325 0.0783 0.1037
Echinococcus granulosus tm gpcr rhodopsin 0.0325 0.0783 0.1037
Onchocerca volvulus 0.0325 0.0783 0.3135
Echinococcus granulosus WGR domain containing protein 0.0763 0.1914 0.2536
Echinococcus granulosus cpg binding protein 0.0036 0.0035 0.0047
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0325 0.0783 0.2063
Brugia malayi G protein-coupled receptor F59B2.13 0.0325 0.0783 0.1708
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0104 0.0102
Schistosoma mansoni steroid hormone receptor ad4bp 0.004 0.0046 0.0061
Loa Loa (eye worm) hypothetical protein 0.0325 0.0783 0.2063
Echinococcus multilocularis nmda type glutamate receptor 0.0079 0.0147 0.0195
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0292 0.0696 0.1511
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0126 0.0268 0.1071
Schistosoma mansoni serine/threonine protein kinase 0.0171 0.0384 0.0509
Loa Loa (eye worm) hypothetical protein 0.0325 0.0783 0.2063
Echinococcus multilocularis neuropeptide FF receptor 2 0.0325 0.0783 0.1037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.004 0.0046 0.012
Echinococcus granulosus sodium:glucose cotransporter 2 0.0037 0.0039 0.0052
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0027 0.0013 0.0018
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0092 0.0181 0.0394
Echinococcus multilocularis solute carrier family 5 0.0037 0.0039 0.0052
Trichomonas vaginalis guanylate cyclase, putative 0.0027 0.0013 0.0045
Brugia malayi MAP kinase sur-1 0.0171 0.0384 0.0838
Schistosoma mansoni neuropeptide receptor 0.0325 0.0783 0.1037
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.0305 0.0404
Brugia malayi Death domain containing protein 0.0031 0.0023 0.005
Chlamydia trachomatis glutamine binding protein 0.0057 0.009 0.0079
Echinococcus multilocularis fmrfamide receptor 0.0325 0.0783 0.1037
Schistosoma mansoni alpha-1 adrenergic receptor 0.0325 0.0783 0.1037
Schistosoma mansoni amine GPCR 0.0325 0.0783 0.1037
Brugia malayi Sodium:solute symporter family protein 0.0037 0.0039 0.0085
Schistosoma mansoni RAR-like nuclear receptor 0.004 0.0046 0.0061
Echinococcus granulosus neuropeptide s receptor 0.1322 0.3358 0.4449
Loa Loa (eye worm) hypothetical protein 0.0062 0.0104 0.0274
Schistosoma mansoni inhibitor of apoptosis protein 0.0177 0.0401 0.0531
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0004 0.0009
Schistosoma mansoni biogenic amine receptor 0.0325 0.0783 0.1037
Echinococcus granulosus peptide allatostatin:somatostatin 0.0325 0.0783 0.1037
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0004 0.0002
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0037 0.0039 0.0052
Echinococcus granulosus TGF beta signal transducer SmadC 0.005 0.007 0.0093
Schistosoma mansoni biogenic amine receptor 0.0325 0.0783 0.1037
Echinococcus multilocularis inhibitor of apoptosis protein 0.0177 0.0401 0.0531
Echinococcus granulosus rhodopsin orphan GPCR 0.0325 0.0783 0.1037
Schistosoma mansoni hypothetical protein 0.0146 0.032 0.0424
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0033 0.0027 0.0072
Trichomonas vaginalis PIKK family atypical protein kinase 0.0062 0.0102 0.0402
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.004 0.0053
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.004 0.0046 0.012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0085 0.0332
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0069 0.0154
Brugia malayi beta-lactamase family protein 0.0038 0.004 0.0088
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0011 0.0035
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0098 0.0257
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0027 0.0013 0.001
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0045 0.0173
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.012 0.0472
Schistosoma mansoni intermediate filament proteins 0.0061 0.0101 0.0133
Schistosoma mansoni topbp1 0.0027 0.0011 0.0015
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0078 0.0144 0.0315
Schistosoma mansoni ap endonuclease 0.0037 0.0038 0.0051
Onchocerca volvulus 0.004 0.0046 0.0166
Loa Loa (eye worm) hypothetical protein 0.0325 0.0783 0.2063
Trichomonas vaginalis conserved hypothetical protein 0.0126 0.0268 0.1071
Echinococcus granulosus serotonin receptor 0.0325 0.0783 0.1037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0073 0.0132 0.0522
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0027 0.0013 0.001
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0046 0.01
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0038 0.0072
Brugia malayi sulfakinin receptor protein 0.0325 0.0783 0.1708
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.004 0.0038
Echinococcus multilocularis neuropeptide receptor 0.0325 0.0783 0.1037
Loa Loa (eye worm) hypothetical protein 0.0325 0.0783 0.2063
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0039 0.0043 0.0102
Schistosoma mansoni aldehyde dehydrogenase 0.0119 0.025 0.0332
Brugia malayi MH2 domain containing protein 0.005 0.007 0.0153
Trichomonas vaginalis esterase, putative 0.0038 0.004 0.0152
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0034 0.0029 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0226 0.0527 0.2111
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0171 0.0384 0.0986
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0027 0.0011 0.0035
Loa Loa (eye worm) hypothetical protein 0.0087 0.0168 0.0442
Echinococcus granulosus alpha 1A adrenergic receptor 0.0325 0.0783 0.1037
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0018 0.0047
Brugia malayi Nuclear hormone receptor family member nhr-31 0.004 0.0046 0.01
Trichomonas vaginalis conserved hypothetical protein 0.0226 0.0527 0.2111
Echinococcus granulosus g protein coupled receptor 0.0325 0.0783 0.1037
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0027 0.0013 0.001
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0865 0.2179 0.574
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0325 0.0783 0.1037
Giardia lamblia Kinase, CMGC MAPK 0.0171 0.0384 0.342
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0092 0.0181 0.0385
Plasmodium falciparum peptide deformylase 0.3893 1 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0104 0.0102
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0104 0.0102
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0018 0.0023
Echinococcus granulosus histone lysine methyltransferase setb 0.0125 0.0265 0.0351
Schistosoma mansoni hypothetical protein 0.0325 0.0783 0.1037
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0031 0.0022 0.0049
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0325 0.0783 0.3135
Echinococcus multilocularis dnaJ subfamily B 0.0484 0.1194 0.1582
Onchocerca volvulus 0.0325 0.0783 0.3135
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0325 0.0783 0.1037
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0038 0.0027
Brugia malayi photoreceptor-specific nuclear receptor 0.004 0.0046 0.01
Echinococcus granulosus g protein coupled receptor 0.0325 0.0783 0.1037
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.01 0.0202 0.0268
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0125 0.0265 0.0351
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0449 0.1102 0.1461
Brugia malayi Dopamine receptor protein 2 0.0325 0.0783 0.1708
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.0305 0.0404
Echinococcus granulosus poly ADP ribose polymerase 1 0.1797 0.4585 0.6075
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.004 0.0046 0.012
Loa Loa (eye worm) hypothetical protein 0.0325 0.0783 0.2063
Echinococcus multilocularis rhodopsin orphan GPCR 0.0325 0.0783 0.1037
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0325 0.0783 0.1708
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.004 0.0152
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0104 0.0409
Brugia malayi Cytochrome P450 family protein 0.005 0.0071 0.0156
Entamoeba histolytica hypothetical protein 0.0226 0.0527 0.1141
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0325 0.0783 0.1037
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0034 0.0029 0.0039
Brugia malayi Nuclear hormone receptor family member nhr-3 0.004 0.0046 0.01
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0027 0.0013 0.001
Brugia malayi bZIP transcription factor family protein 0.009 0.0174 0.038
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0069 0.0067
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.012 0.0472
Brugia malayi ORL1-like opioid receptor 0.0325 0.0783 0.1708
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0027 0.0013 0.001
Schistosoma mansoni high-affinity choline transporter 0.0339 0.0819 0.1085
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0027 0.0013 0.0002
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0171 0.0384 0.0986
Brugia malayi hypothetical protein 0.0354 0.0858 0.1871
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0046 0.0061
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0325 0.0783 0.1037
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0126 0.0268 0.1071
Loa Loa (eye worm) hypothetical protein 0.005 0.0071 0.0188
Schistosoma mansoni tankyrase 0.0226 0.0527 0.0699
Loa Loa (eye worm) hypothetical protein 0.0086 0.0164 0.0431
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0038 0.0041 0.008
Entamoeba histolytica hypothetical protein 0.0226 0.0527 0.1141
Loa Loa (eye worm) hypothetical protein 0.0325 0.0783 0.2063
Echinococcus multilocularis expressed protein 0.004 0.0045 0.006
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0057 0.009 0.0079
Brugia malayi Bromodomain containing protein 0.0029 0.0018 0.0039
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.004 0.0038
Echinococcus multilocularis thyroid hormone receptor alpha 0.03 0.0718 0.0951
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0177 0.0401 0.0531
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0061 0.0101 0.0265
Brugia malayi Immunoglobulin I-set domain containing protein 0.0031 0.0023 0.005
Echinococcus multilocularis X box binding protein 1 0.0283 0.0673 0.0892
Echinococcus multilocularis rhodopsin orphan GPCR 0.0325 0.0783 0.1037
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0027 0.0013 0.001
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0078 0.0144 0.0191
Trypanosoma brucei poly(adp-ribose) polymerase 0.1491 0.3796 1
Trichomonas vaginalis rotamase, putative 0.004 0.0045 0.0173
Onchocerca volvulus Netrin receptor homolog 0.0031 0.0023 0.0076
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.004 0.0046 0.0061
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0027 0.0013 0.001
Echinococcus granulosus rhodopsin orphan GPCR 0.0325 0.0783 0.1037
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0078 0.0144 0.0306
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0027 0.0013 0.001
Schistosoma mansoni hypothetical protein 0.0484 0.1194 0.1582
Schistosoma mansoni aryl hydrocarbon receptor 0.0106 0.0215 0.0285
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0449 0.1102 0.1461
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0325 0.0783 0.1037
Brugia malayi topoisomerase 0.0027 0.0011 0.0024
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0038 0.0084
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.3893 1 1
Schistosoma mansoni hypothetical protein 0.0177 0.0399 0.0529
Echinococcus multilocularis musashi 0.0061 0.0101 0.0133
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.009 0.0174 0.0231
Echinococcus granulosus neuropeptides capa receptor 0.0325 0.0783 0.1037
Loa Loa (eye worm) hypothetical protein 0.0716 0.1793 0.4724
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.1485 0.378 0.9959
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.004 0.0038
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0027 0.0013 0.0045
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.004 0.0038
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0177 0.0399 0.0529
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0027 0.0013 0.001
Echinococcus granulosus sex peptide receptor 0.0325 0.0783 0.1037
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0004 0.0002
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0325 0.0783 0.1037
Loa Loa (eye worm) hypothetical protein 0.0325 0.0783 0.2063
Loa Loa (eye worm) hypothetical protein 0.0177 0.0401 0.1057
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0027 0.0013 0.001
Onchocerca volvulus 0.0325 0.0783 0.3135
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0126 0.0268 0.0356
Echinococcus granulosus neuropeptide Y receptor 0.0325 0.0783 0.1037
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.004 0.0152
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0177 0.0401 0.0531
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0062 0.0104 0.0409
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0062 0.0104 0.0245
Brugia malayi DKFZp564C0469 protein 0.0027 0.0011 0.0024
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0027 0.0011 0.0035
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0062 0.0104 0.0102
Echinococcus granulosus lamin 0.0061 0.0101 0.0133
Schistosoma mansoni cpg binding protein 0.0036 0.0035 0.0047
Loa Loa (eye worm) hypothetical protein 0.0028 0.0016 0.0042
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.004 0.0088
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0171 0.0384 0.1006
Loa Loa (eye worm) hypothetical protein 0.0378 0.0918 0.2418
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0018 0.0023
Mycobacterium leprae Conserved hypothetical protein 0.0027 0.0013 0.001
Loa Loa (eye worm) hypothetical protein 0.0325 0.0783 0.2063
Echinococcus granulosus dro:myosuppressin receptor 0.0325 0.0783 0.1037
Schistosoma mansoni biogenic amine (5HT) receptor 0.0325 0.0783 0.1037
Mycobacterium ulcerans hypothetical protein 0.0038 0.004 0.0038
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.004 0.0152
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0027 0.0013 0.001
Entamoeba histolytica hypothetical protein 0.0226 0.0527 0.1141
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0171 0.0384 0.1012
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0177 0.0401 0.0531
Brugia malayi hypothetical protein 0.0325 0.0783 0.1708
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0027 0.0013 0.0004
Loa Loa (eye worm) intermediate filament protein 0.0061 0.0101 0.0265
Loa Loa (eye worm) cytochrome P450 family protein 0.0066 0.0113 0.0297
Mycobacterium ulcerans hypothetical protein 0.0024 0.0004 0.0002
Trypanosoma brucei Peptide deformylase 2 0.1485 0.378 0.9959
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0126 0.0268 0.1071
Schistosoma mansoni biogenic amine (5HT) receptor 0.0325 0.0783 0.1037
Echinococcus granulosus somatostatin receptor 0.0325 0.0783 0.1037
Brugia malayi larval opioid receptor 0.0325 0.0783 0.1708
Mycobacterium leprae Possible regulatory protein 0.0027 0.0013 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0013 0.0045
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0031 0.0024 0.0032
Mycobacterium tuberculosis Conserved protein 0.0038 0.004 0.0038
Brugia malayi hypothetical protein 0.0032 0.0024 0.0053
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0038 0.0051
Echinococcus multilocularis rhodopsin orphan GPCR 0.0325 0.0783 0.1037
Brugia malayi MH1 domain containing protein 0.005 0.007 0.0153
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0039 0.0043 0.0084
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0559 0.1386 0.3652
Schistosoma mansoni tar DNA-binding protein 0.045 0.1104 0.1463
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.01 0.0202 0.0268
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0126 0.0268 0.0355
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0126 0.0268 0.1071
Schistosoma mansoni thyroid hormone receptor 0.03 0.0718 0.0951
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0027 0.0013 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0022 0.0081
Brugia malayi Cytochrome P450 family protein 0.0027 0.0013 0.0028
Schistosoma mansoni Tr4/Tr2 (homologue) 0.004 0.0046 0.0061
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0038 0.0145
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0062 0.0104 0.0227
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0034 0.0029 0.0039
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0062 0.0104 0.0138
Onchocerca volvulus 0.0202 0.0465 0.1856
Echinococcus granulosus tm gpcr rhodopsin 0.0325 0.0783 0.1037
Brugia malayi Calcitonin receptor-like protein seb-1 0.0559 0.1386 0.3024
Echinococcus multilocularis peregrin 0.0029 0.0018 0.0023
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0073 0.0132 0.032
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.004 0.0046 0.012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.012 0.0472
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.004 0.0077
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0027 0.0013 0.0022
Trypanosoma brucei protein kinase, putative 0.0171 0.0384 0.0986
Schistosoma mansoni smad 0.005 0.007 0.0093
Loa Loa (eye worm) hypothetical protein 0.0062 0.0104 0.0274
Loa Loa (eye worm) hypothetical protein 0.0325 0.0783 0.2063
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0325 0.0783 0.2063
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0325 0.0783 0.1708
Mycobacterium ulcerans putative regulatory protein 0.0078 0.0144 0.0142
Loa Loa (eye worm) hypothetical protein 0.0027 0.0011 0.0029
Onchocerca volvulus 0.0037 0.0039 0.014
Loa Loa (eye worm) G-protein coupled receptor 0.0325 0.0783 0.2063
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.014 0.0305 0.0665
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0325 0.0783 0.1037
Leishmania major hypothetical protein, conserved 0.0049 0.0069 0.0172
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.004 0.0046 0.012
Mycobacterium tuberculosis Conserved protein 0.0038 0.004 0.0038
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0027 0.0011 0.0009
Brugia malayi hypothetical protein 0.0049 0.0069 0.0151
Loa Loa (eye worm) hypothetical protein 0.0325 0.0783 0.2063
Leishmania major cAMP-specific phosphodiesterase, putative 0.0062 0.0104 0.0264
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0004 0.0002
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0086 0.0164 0.0357
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0325 0.0783 0.1037
Toxoplasma gondii exonuclease III APE 0.0037 0.0038 0.0036
Trichomonas vaginalis rotamase, putative 0.0039 0.0043 0.0163
Brugia malayi hypothetical protein 0.0325 0.0783 0.1708
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0018 0.0015
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0062 0.0104 0.0409
Loa Loa (eye worm) hypothetical protein 0.0325 0.0783 0.2063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0073 0.0132 0.0522
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0126 0.0268 0.1071
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0043 0.0084
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0062 0.0104 0.0409
Echinococcus granulosus G protein coupled receptor 139 0.0325 0.0783 0.1037
Loa Loa (eye worm) neuropeptide F receptor 0.0325 0.0783 0.2063
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.0069 0.0067
Brugia malayi nuclear receptor NHR-88 0.004 0.0046 0.01
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0027 0.0013 0.001
Brugia malayi neuropeptide F receptor 0.0325 0.0783 0.1708
Giardia lamblia hypothetical protein 0.0062 0.0104 0.0851
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0325 0.0783 0.1037
Echinococcus granulosus nibrin 0.0027 0.0011 0.0015
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0449 0.1102 0.1461
Schistosoma mansoni retinoid-x-receptor (RXR) 0.004 0.0046 0.0061
Echinococcus granulosus rhodopsin orphan GPCR 0.0325 0.0783 0.1037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0092 0.0181 0.0718
Echinococcus multilocularis rhodopsin orphan GPCR 0.0325 0.0783 0.1037
Loa Loa (eye worm) hypothetical protein 0.0325 0.0783 0.2063
Brugia malayi beta-lactamase 0.0038 0.004 0.0088
Schistosoma mansoni TGF-beta signal transducer Smad2 0.005 0.007 0.0093
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0013 0.0045
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0372 0.0904 0.1198
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.004 0.0046 0.0061
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0062 0.0104 0.0227
Loa Loa (eye worm) CYP4Cod1 0.0066 0.0113 0.0297
Echinococcus multilocularis Smad4 0.005 0.007 0.0093
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0071 0.0277
Echinococcus granulosus sodium:glucose cotransporter 0.0037 0.0039 0.0052
Leishmania major cytochrome p450-like protein 0.0027 0.0013 0.0022
Onchocerca volvulus 0.0325 0.0783 0.3135
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.0696 0.2793
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.004 0.0053
Loa Loa (eye worm) hypothetical protein 0.0038 0.004 0.0106
Brugia malayi Serotonin receptor 0.0325 0.0783 0.1708
Trichomonas vaginalis conserved hypothetical protein 0.0226 0.0527 0.2111
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0031 0.0022 0.003
Echinococcus multilocularis FTZ F1 alpha 0.004 0.0046 0.0061
Loa Loa (eye worm) hypothetical protein 0.1069 0.2703 0.7122
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0126 0.0268 0.1071
Brugia malayi hypothetical protein 0.0325 0.0783 0.1708
Brugia malayi RNA binding protein 0.045 0.1104 0.2408
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0027 0.0013 0.0006
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0103 0.0209 0.0831
Trypanosoma cruzi Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.0088 0.0171 0.0423
Onchocerca volvulus Alhambra homolog 0.0029 0.0018 0.0054
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0057 0.009 0.0079
Giardia lamblia Hypothetical protein 0.0062 0.0104 0.0851
Schistosoma mansoni myosin xvIII 0.0325 0.0783 0.1037
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0027 0.0013 0.001
Brugia malayi MH1 domain containing protein 0.0027 0.0013 0.0029
Echinococcus multilocularis Ankyrin 0.0031 0.0024 0.0032
Echinococcus multilocularis allatostatin A receptor 0.0325 0.0783 0.1037
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0062 0.0104 0.0102
Schistosoma mansoni inositol transporter 0.0037 0.0039 0.0052
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0031 0.0022 0.003
Loa Loa (eye worm) hypothetical protein 0.0325 0.0783 0.2063
Loa Loa (eye worm) poly(ADP-ribose) polymerase 0.1018 0.2572 0.6776
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0046 0.01
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0372 0.0904 0.1198
Loa Loa (eye worm) hypothetical protein 0.0177 0.0401 0.1057
Echinococcus granulosus ecdysone induced protein 78C 0.004 0.0046 0.0061
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0103 0.0209 0.0522
Echinococcus granulosus mothers against decapentaplegic 5 0.005 0.007 0.0093
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0126 0.0268 0.068
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0038 0.025
Schistosoma mansoni amine GPCR 0.0325 0.0783 0.1037
Brugia malayi Latrophilin receptor protein 2 0.0177 0.0399 0.0871
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0031 0.0022 0.0048
Loa Loa (eye worm) beta-lactamase 0.0038 0.004 0.0106
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0034 0.0029 0.0039
Brugia malayi G-protein coupled receptor 0.0325 0.0783 0.1708
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0004 0.0009
Loa Loa (eye worm) hypothetical protein 0.0325 0.0783 0.2063
Loa Loa (eye worm) PDE1B protein 0.0062 0.0104 0.0274
Echinococcus multilocularis microtubule associated protein 2 0.2943 0.7547 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0062 0.0104 0.0409
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0006 0.0017
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0325 0.0783 0.1037
Leishmania major phosphatidylinositol 3-kinase, putative 0.0031 0.0022 0.0048
Echinococcus multilocularis cpg binding protein 0.0036 0.0035 0.0047
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0034 0.0029 0.0039
Brugia malayi Nuclear hormone receptor-like 1 0.004 0.0046 0.01
Brugia malayi Nuclear hormone receptor family member nhr-14 0.004 0.0046 0.01
Onchocerca volvulus Deterin homolog 0.0177 0.0401 0.1597
Echinococcus multilocularis rhodopsin orphan GPCR 0.0325 0.0783 0.1037
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0125 0.0265 0.0351
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0125 0.0265 0.0351
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.004 0.0046 0.0061
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.045 0.1104 0.2908
Echinococcus granulosus death domain containing protein 0.0031 0.0023 0.0031
Trypanosoma cruzi hypothetical protein, conserved 0.0062 0.0104 0.0245
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0004 0.0002
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0075 0.0137 0.0135
Echinococcus multilocularis tumor protein p63 0.1382 0.3514 0.4656
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0027 0.0011 0.0015
Brugia malayi Melibiase family protein 0.0067 0.0116 0.0252
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0004 0.0009
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0171 0.0384 0.1006
Loa Loa (eye worm) hypothetical protein 0.0325 0.0783 0.2063
Brugia malayi RNA recognition motif domain containing protein 0.045 0.1104 0.2408
Plasmodium vivax replication factor C subunit 1, putative 0.0027 0.0011 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.012 0.0472
Toxoplasma gondii peptidylprolyl isomerase 0.0039 0.0043 0.0041
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0038 0.0036
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0325 0.0783 0.1037
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0143 0.0311 0.0309
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0325 0.0783 0.1037
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.0696 0.2793
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0325 0.0783 0.1037
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0018 0.0023
Trichomonas vaginalis CMGC family protein kinase 0.0171 0.0384 0.1537
Loa Loa (eye worm) hypothetical protein 0.0684 0.171 0.4505
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0086 0.0164 0.065
Echinococcus multilocularis neuropeptides capa receptor 0.0325 0.0783 0.1037
Mycobacterium ulcerans lipase LipD 0.0038 0.004 0.0038
Echinococcus granulosus microtubule associated protein 2 0.2943 0.7547 1
Schistosoma mansoni tar DNA-binding protein 0.045 0.1104 0.1463
Trypanosoma brucei cytochrome P450, putative 0.0066 0.0113 0.0269
Echinococcus granulosus survival motor neuron protein 1 0.0716 0.1793 0.2376
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0107 0.0422
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0078 0.0144 0.0353
Brugia malayi PAS domain containing protein 0.0106 0.0215 0.047
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0034 0.0029 0.0039
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0004 0.0002
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.004 0.0106
Trypanosoma cruzi hypothetical protein, conserved 0.0062 0.0104 0.0245
Echinococcus granulosus dnaJ subfamily B 0.0484 0.1194 0.1582
Echinococcus multilocularis neuropeptide s receptor 0.1322 0.3358 0.4449
Leishmania major DNA repair protein, putative 0.0088 0.0171 0.0442
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0078 0.0144 0.0371
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0078 0.0144 0.0191
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0325 0.0783 0.1037
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0092 0.0181 0.0448
Onchocerca volvulus 0.0325 0.0783 0.3135
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0177 0.0401 0.0875
Leishmania major hypothetical protein, conserved 0.0088 0.0171 0.0442
Onchocerca volvulus 0.0034 0.003 0.0105
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0022 0.0081
Echinococcus multilocularis mitogen activated protein kinase 3 0.0171 0.0384 0.0509
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0038 0.0036
Echinococcus granulosus high affinity choline transporter 1 0.0339 0.0819 0.1085
Brugia malayi jmjC domain containing protein 0.0037 0.0038 0.0084
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0062 0.0104 0.0102
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0029 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0038 0.004 0.0106
Loa Loa (eye worm) hypothetical protein 0.0325 0.0783 0.2063
Schistosoma mansoni ap endonuclease 0.0037 0.0038 0.0051
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0325 0.0783 0.1037
Loa Loa (eye worm) hypothetical protein 0.0061 0.0101 0.0265
Onchocerca volvulus 0.0325 0.0783 0.3135
Loa Loa (eye worm) hypothetical protein 0.004 0.0046 0.012
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.1823 0.4653 0.4652
Toxoplasma gondii target of rapamycin (TOR), putative 0.0069 0.012 0.0117
Echinococcus multilocularis 0.0027 0.0013 0.0017
Leishmania major polypeptide deformylase-like protein, putative 0.1485 0.378 1
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0047 0.0062
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0027 0.0013 0.001
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0177 0.0399 0.0871
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0325 0.0783 0.1037
Brugia malayi MH1 domain containing protein 0.005 0.007 0.0153
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0027 0.0013 0.001
Loa Loa (eye worm) hypothetical protein 0.0067 0.0116 0.0305
Echinococcus multilocularis poly (ADP ribose) polymerase 1 0.1797 0.4585 0.6075
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0104 0.0102
Echinococcus granulosus 7tm_1 domain containing protein 0.0325 0.0783 0.1037
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0104 0.0102
Echinococcus granulosus mitogen activated protein kinase 0.0171 0.0384 0.0509
Brugia malayi hypothetical protein 0.0145 0.0317 0.0691
Loa Loa (eye worm) hypothetical protein 0.0559 0.1386 0.3652
Schistosoma mansoni survival motor neuron protein 0.0146 0.032 0.0424
Echinococcus granulosus 7TM GPCR rhodopsin 0.0325 0.0783 0.1037
Loa Loa (eye worm) melatonin receptor type 1A 0.0325 0.0783 0.2063
Echinococcus granulosus hypothetical protein 0.0325 0.0783 0.1037
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0062 0.0104 0.0138
Trypanosoma cruzi target of rapamycin kinase 3 0.0073 0.0132 0.032
Loa Loa (eye worm) hypothetical protein 0.0038 0.004 0.0106
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0104 0.0102
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0126 0.0268 0.1071
Brugia malayi ecdysteroid receptor 0.004 0.0046 0.01
Echinococcus multilocularis neuropeptide receptor 0.0325 0.0783 0.1037
Echinococcus granulosus expressed protein 0.004 0.0045 0.006
Echinococcus multilocularis mitogen activated protein kinase 0.0171 0.0384 0.0509
Loa Loa (eye worm) hypothetical protein 0.0325 0.0783 0.2063
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0071 0.0276
Mycobacterium ulcerans peptide deformylase 0.3893 1 1
Loa Loa (eye worm) cytochrome P450 0.0027 0.0013 0.0033
Mycobacterium tuberculosis Conserved protein 0.0038 0.004 0.0038
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0062 0.0104 0.0102
Brugia malayi RE15519p 0.0325 0.0783 0.1708
Trichomonas vaginalis conserved hypothetical protein 0.0226 0.0527 0.2111
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0092 0.0181 0.0239
Schistosoma mansoni poly [ADP-ribose] polymerase 0.1797 0.4585 0.6075
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0062 0.0104 0.0102
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0029 0.0017 0.0017
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0325 0.0783 0.1037
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0107 0.0422
Schistosoma mansoni tar DNA-binding protein 0.045 0.1104 0.1463
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0092 0.0181 0.0385
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0126 0.0268 0.1071
Brugia malayi jmjC domain containing protein 0.0095 0.0189 0.0412
Onchocerca volvulus 0.0325 0.0783 0.3135
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0027 0.0013 0.001
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.01 0.0202 0.0268
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0011 0.0035
Brugia malayi MH2 domain containing protein 0.005 0.007 0.0153
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0449 0.1102 0.1461
Echinococcus granulosus cytochrome P450 2K1 0.0027 0.0013 0.0017
Trichomonas vaginalis CMGC family protein kinase 0.0171 0.0384 0.1537
Toxoplasma gondii hypothetical protein 0.3893 1 1
Trichomonas vaginalis adenylate cyclase, putative 0.0027 0.0013 0.0045
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.004 0.0046 0.012
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0325 0.0783 0.1037
Loa Loa (eye worm) neuropeptide F receptor 0.0325 0.0783 0.2063
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0062 0.0104 0.0409
Echinococcus granulosus neuropeptide receptor A26 0.1322 0.3358 0.4449
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.004 0.0046 0.0061
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0126 0.0268 0.1071
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0062 0.0104 0.0245
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0325 0.0783 0.1037
Loa Loa (eye worm) hypothetical protein 0.004 0.0046 0.012
Echinococcus multilocularis rhodopsin orphan GPCR 0.0325 0.0783 0.1037
Entamoeba histolytica hypothetical protein 0.0372 0.0904 0.1964
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0143 0.0311 0.0309
Loa Loa (eye worm) hypothetical protein 0.0028 0.0016 0.0042
Plasmodium falciparum phosphodiesterase gamma, putative 0.0062 0.0104 0.0102
Echinococcus multilocularis jun protein 0.009 0.0174 0.0231
Loa Loa (eye worm) phosphatidylinositol 3 0.0092 0.0181 0.0476
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.1491 0.3796 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0039 0.0103
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0092 0.0181 0.0467
Brugia malayi Smad1 0.005 0.007 0.0153
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0126 0.0268 0.1071
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.004 0.0038
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0143 0.0311 0.0309
Schistosoma mansoni microtubule-associated protein tau 0.2943 0.7547 1
Loa Loa (eye worm) hypothetical protein 0.1491 0.3796 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0104 0.0102
Loa Loa (eye worm) hypothetical protein 0.0325 0.0783 0.2063
Trypanosoma cruzi hypothetical protein, conserved 0.0062 0.0104 0.0245
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0126 0.0268 0.1071
Loa Loa (eye worm) RNA binding protein 0.045 0.1104 0.2908
Echinococcus multilocularis rhodopsin orphan GPCR 0.0325 0.0783 0.1037
Schistosoma mansoni lamin 0.0061 0.0101 0.0133
Toxoplasma gondii endonuclease IV APN 0.0075 0.0137 0.0135
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0004 0.0002
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0559 0.1386 0.3024
Loa Loa (eye worm) MH2 domain-containing protein 0.0727 0.182 0.4794
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0004 0.0002
Echinococcus multilocularis sex peptide receptor 0.0325 0.0783 0.1037
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0027 0.0011 0.0035
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0044 0.0055 0.0117
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0104 0.0102
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0146 0.032 0.0698
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0449 0.1102 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0126 0.0268 0.068
Onchocerca volvulus 0.0985 0.2488 1
Schistosoma mansoni histamine h1 receptor 0.0325 0.0783 0.1037
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.004 0.0152
Loa Loa (eye worm) hypothetical protein 0.0325 0.0783 0.2063
Schistosoma mansoni adenoreceptor 0.0325 0.0783 0.1037
Echinococcus granulosus GPCR family 2 0.0177 0.0399 0.0529
Trichomonas vaginalis PIKK family atypical protein kinase 0.0092 0.0181 0.0718
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.004 0.0046 0.012
Echinococcus granulosus g-protein coupled receptor 0.0325 0.0783 0.1037
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0325 0.0783 0.1037
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0027 0.0013 0.001
Toxoplasma gondii ABC1 family protein 0.0038 0.004 0.0038
Echinococcus granulosus g protein coupled receptor 0.0325 0.0783 0.1037
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0027 0.0013 0.001
Trichomonas vaginalis replication factor C large subunit, putative 0.0027 0.0011 0.0035
Echinococcus multilocularis orexin receptor type 2 0.0325 0.0783 0.1037
Loa Loa (eye worm) hypothetical protein 0.0024 0.0004 0.0011
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0325 0.0783 0.1037
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0325 0.0783 0.1037
Echinococcus multilocularis glutamate receptor 2 0.0034 0.0029 0.0039
Schistosoma mansoni neuropeptide F-like receptor 0.0325 0.0783 0.1037
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0062 0.0104 0.0245
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0057 0.009 0.0079
Echinococcus granulosus Ankyrin 0.0031 0.0024 0.0032
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0069 0.0067
Echinococcus granulosus jun protein 0.009 0.0174 0.0231
Brugia malayi hypothetical protein 0.0027 0.0011 0.0024
Brugia malayi hypothetical protein 0.0325 0.0783 0.1708
Loa Loa (eye worm) hypothetical protein 0.0325 0.0783 0.2063
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0062 0.0104 0.0409
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0027 0.0013 0.001
Brugia malayi Pax transcription activation domain interacting protein 0.0027 0.0011 0.0024
Loa Loa (eye worm) hypothetical protein 0.0075 0.0137 0.036
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0046 0.01
Echinococcus multilocularis survival motor neuron protein 1 0.0716 0.1793 0.2376
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.0696 0.2793
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0086 0.0164 0.0217
Loa Loa (eye worm) hypothetical protein 0.0038 0.004 0.0106
Loa Loa (eye worm) hypothetical protein 0.0027 0.0011 0.0029
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.0696 0.2793
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0325 0.0783 0.1037
Echinococcus granulosus fmrfamide receptor 0.0325 0.0783 0.1037
Onchocerca volvulus DNA ligase 3 homolog 0.0088 0.0171 0.0671
Brugia malayi AKH receptor 0.0325 0.0783 0.1708
Echinococcus multilocularis lamin dm0 0.0061 0.0101 0.0133
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0062 0.0104 0.0245
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0027 0.0013 0.001
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0027 0.0013 0.0045
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.004 0.0046 0.0061
Schistosoma mansoni hypothetical protein 0.0325 0.0783 0.1037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0073 0.0132 0.0522
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0092 0.0181 0.0448
Schistosoma mansoni hypothetical protein 0.0325 0.0783 0.1037
Loa Loa (eye worm) cytochrome P450 family protein 0.005 0.0071 0.0188
Echinococcus granulosus rhodopsin orphan GPCR 0.0325 0.0783 0.1037
Echinococcus granulosus neuropeptide FF receptor 2 0.0325 0.0783 0.1037
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0449 0.1102 0.1461
Schistosoma mansoni opsin-like receptor 0.0325 0.0783 0.1037
Brugia malayi Protein kinase domain containing protein 0.0033 0.0027 0.0059
Schistosoma mansoni neuropeptide receptor 0.0325 0.0783 0.1037
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0004 0.0002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0325 0.0783 0.1037
Schistosoma mansoni rotamase 0.004 0.0045 0.006
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0177 0.0399 0.0529
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0062 0.0104 0.0227
Echinococcus granulosus poly (ADP ribose) polymerase 0.0763 0.1914 0.2536
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0038 0.0074
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0027 0.0013 0.001
Echinococcus granulosus inhibitor of apoptosis protein 0.0177 0.0401 0.0531
Echinococcus granulosus aryl hydrocarbon receptor 0.0027 0.0013 0.0018
Echinococcus granulosus nmda type glutamate receptor 0.0079 0.0147 0.0195
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0038 0.0051
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0027 0.0013 0.001
Mycobacterium ulcerans endonuclease IV 0.0075 0.0137 0.0135
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0029 0.0017 0.0017
Schistosoma mansoni netrin receptor unc5 0.0031 0.0023 0.0031
Loa Loa (eye worm) hypothetical protein 0.0325 0.0783 0.2063
Echinococcus multilocularis neuropeptide Y receptor 0.0325 0.0783 0.1037
Leishmania major hypothetical protein, conserved 0.0062 0.0104 0.0264
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0104 0.0409
Loa Loa (eye worm) MH2 domain-containing protein 0.005 0.007 0.0185
Echinococcus granulosus tar DNA binding protein 0.045 0.1104 0.1463
Schistosoma mansoni poly [ADP-ribose] polymerase 0.1265 0.3211 0.4255
Entamoeba histolytica zinc finger protein, putative 0.0226 0.0527 0.1141
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0027 0.0013 0.001
Brugia malayi hypothetical protein 0.0716 0.1793 0.3911
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0126 0.0268 0.1071
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0126 0.0268 0.1071
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0062 0.0104 0.0138
Onchocerca volvulus 0.0325 0.0783 0.3135
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0086 0.0164 0.0217
Echinococcus multilocularis geminin 0.0201 0.0461 0.0611
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0119 0.0251 0.0333
Echinococcus granulosus poly (ADP ribose) polymerase 0.0474 0.1166 0.1545
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0027 0.0013 0.0018
Schistosoma mansoni jun-related protein 0.0073 0.0131 0.0173
Chlamydia trachomatis endonuclease IV 0.0075 0.0137 0.0126
Echinococcus multilocularis transcription factor Dp 1 0.0045 0.0059 0.0079
Entamoeba histolytica hypothetical protein 0.0372 0.0904 0.1964
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0034 0.0029 0.0039
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0062 0.0104 0.0138
Trichomonas vaginalis PIKK family atypical protein kinase 0.006 0.0097 0.0382
Onchocerca volvulus 0.0325 0.0783 0.3135
Schistosoma mansoni hypothetical protein 0.0029 0.0018 0.0023
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0104 0.0102
Loa Loa (eye worm) hypothetical protein 0.0027 0.0013 0.0035
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0027 0.0013 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.012 0.0472
Loa Loa (eye worm) hypothetical protein 0.004 0.0046 0.012
Mycobacterium ulcerans aldehyde dehydrogenase 0.0119 0.025 0.0248
Schistosoma mansoni cpg binding protein 0.0036 0.0035 0.0047
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0046 0.01
Loa Loa (eye worm) hypothetical protein 0.0325 0.0783 0.2063
Brugia malayi nuclear hormone receptor 0.004 0.0046 0.01
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0171 0.0384 0.0986
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0126 0.0268 0.1071
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0062 0.0104 0.0138
Brugia malayi follicle stimulating hormone receptor 0.1323 0.3361 0.733
Schistosoma mansoni chromosome transmission fidelity factor 0.0027 0.0011 0.0015
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0126 0.0268 0.0356
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0104 0.0102
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0325 0.0783 0.1037
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0057 0.009 0.0088
Mycobacterium leprae Probable lipase LipE 0.0038 0.004 0.0038
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0062 0.0104 0.0227
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0086 0.0164 0.0217
Trichomonas vaginalis PIKK family atypical protein kinase 0.0092 0.0181 0.0718
Echinococcus multilocularis TGF beta signal transducer SmadC 0.005 0.007 0.0093
Echinococcus granulosus rhodopsin orphan GPCR 0.0325 0.0783 0.1037
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0071 0.0277
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.0305 0.0404
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0038 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0085 0.0332
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0126 0.0268 0.1071
Echinococcus granulosus single minded 2 0.0078 0.0144 0.0191
Echinococcus granulosus solute carrier family 5 0.0037 0.0039 0.0052
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0325 0.0783 0.1037
Brugia malayi cytoplasmic intermediate filament protein 0.0033 0.0027 0.0059
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0024 0.0004 0.0011
Echinococcus multilocularis high affinity choline transporter 1 0.0339 0.0819 0.1085
Giardia lamblia GTOR 0.0092 0.0181 0.1555
Trypanosoma cruzi hypothetical protein, conserved 0.0062 0.0104 0.0245
Brugia malayi Uncoordinated protein 44 0.0031 0.0023 0.005
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0027 0.0013 0.001
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0062 0.0104 0.0102
Mycobacterium ulcerans aldehyde dehydrogenase 0.0119 0.025 0.0248
Loa Loa (eye worm) hypothetical protein 0.0325 0.0783 0.2063
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0031 0.0022 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0071 0.0277
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0031 0.0022 0.003
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0031 0.0022 0.003
Brugia malayi Pre-SET motif family protein 0.0125 0.0265 0.0578
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0039 0.0043 0.0084
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0119 0.025 0.0332
Echinococcus multilocularis g protein coupled receptor 0.0325 0.0783 0.1037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0022 0.0081
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0325 0.0783 0.1037
Loa Loa (eye worm) hypothetical protein 0.0325 0.0783 0.2063
Entamoeba histolytica hypothetical protein 0.0027 0.0011 0.0015
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0027 0.0013 0.0004
Schistosoma mansoni hypothetical protein 0.0177 0.0399 0.0529
Onchocerca volvulus 0.0177 0.0401 0.1597
Schistosoma mansoni cellular tumor antigen P53 0.0202 0.0465 0.0616
Mycobacterium leprae putative cytochrome p450 0.0027 0.0013 0.001
Loa Loa (eye worm) hypothetical protein 0.0325 0.0783 0.2063
Schistosoma mansoni hypothetical protein 0.0061 0.0101 0.0133

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.07 mM Tested in vitro for the concentration to inhibit sLex bearing HL-60 cells binding to Selectin P-IgG fusion proteins ChEMBL. 9544210
IC50 (binding) = 0.5 mM Tested in vitro for the concentration to inhibit sLex bearing HL-60 cells binding to Selectin E-IgG fusion proteins by 50%. ChEMBL. 9544210
IC50 (binding) = 0.56 mM Tested in vitro for the concentration to inhibit sLex bearing HL-60 cells binding to Selectin L-IgG fusion proteins ChEMBL. 9544210

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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