Detailed information for compound 1783247

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 287.741 | Formula: C16H14ClNO2
  • H donors: 1 H acceptors: 1 LogP: 3.16 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1CCc2c(N1)cc(cc2)OCc1cccc(c1)Cl
  • InChi: 1S/C16H14ClNO2/c17-13-3-1-2-11(8-13)10-20-14-6-4-12-5-7-16(19)18-15(12)9-14/h1-4,6,8-9H,5,7,10H2,(H,18,19)
  • InChiKey: YODAVEOGBVTERT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens monoamine oxidase B Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH Get druggable targets OG5_130722 All targets in OG5_130722
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) Get druggable targets OG5_130722 All targets in OG5_130722
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH Get druggable targets OG5_130722 All targets in OG5_130722
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi amine oxidase, flavin-containing family protein monoamine oxidase B 520 aa 462 aa 19.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus lysine specific histone demethylase 1A 0.0025 0.007 0.0066
Trichomonas vaginalis penicillin-binding protein, putative 0.014 0.0759 0.3883
Loa Loa (eye worm) hypothetical protein 0.0069 0.0335 0.0331
Loa Loa (eye worm) eye-specific diacylglycerol kinase 0.0065 0.031 0.0307
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.01 0.0096
Echinococcus granulosus intestinal type alkaline phosphatase 0.0158 0.087 0.0867
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.01 0.0522 0.151
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.01 0.0096
Brugia malayi acetyltransferase, GNAT family protein 0.0146 0.0796 0.4173
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.0556 0.0556
Loa Loa (eye worm) hypothetical protein 0.0151 0.0824 0.0821
Schistosoma mansoni hypothetical protein 0.0166 0.0916 0.0916
Schistosoma mansoni hypothetical protein 0.0331 0.1912 0.1912
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.002 0.004 0.011
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0128 0.0688 0.1973
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0027 0.0078 0.0075
Loa Loa (eye worm) hypothetical protein 0.003 0.01 0.0096
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0203 0.0203
Brugia malayi PHD-finger family protein 0.0057 0.0258 0.1341
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0025 0.007 0.0308
Entamoeba histolytica acyl-coA synthetase, putative 0.0069 0.0335 0.0335
Mycobacterium tuberculosis Probable lipase LipD 0.014 0.0759 0.0749
Leishmania major 4-coumarate:coa ligase-like protein 0.0069 0.0335 0.0966
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.002 0.004 0.0037
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.01 0.01
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0468 0.0465
Echinococcus granulosus methyl CpG binding domain protein 2 0.0033 0.0117 0.0113
Mycobacterium ulcerans acyl-CoA synthetase 0.0069 0.0335 0.0296
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.01 0.0506
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.01 0.0506
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.01 0.01
Loa Loa (eye worm) jmjC domain-containing protein 0.0067 0.0321 0.0318
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.01 0.0506
Mycobacterium ulcerans DNA polymerase IV 0.0154 0.0847 0.081
Mycobacterium ulcerans diacylglycerol kinase 0.0065 0.031 0.0271
Brugia malayi jmjC domain containing protein 0.0016 0.0012 0.0043
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0014 0.001
Entamoeba histolytica diacylglycerol kinase, putative 0.0065 0.031 0.031
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0056 0.0252 0.1273
Trypanosoma cruzi UDP-galactopyranose mutase 0.0025 0.007 0.0196
Echinococcus multilocularis dna polymerase eta 0.0152 0.0834 0.0831
Trichomonas vaginalis bmru protein, putative 0.0065 0.031 0.1483
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0052 0.0229 0.0218
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0056 0.0252 0.0249
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.0109 0.0515
Leishmania major DNA damage repair protein, putative 0.0032 0.011 0.0313
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.009 0.0112
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.014 0.0759 0.0759
Schistosoma mansoni ferritin 0.0025 0.0068 0.0068
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0113 0.0429
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0025 0.0068 0.0057
Mycobacterium tuberculosis Probable conserved lipoprotein 0.014 0.0759 0.0749
Schistosoma mansoni hypothetical protein 0.0331 0.1912 0.1912
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0243 0.024
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.01 0.0506
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0065 0.031 0.0896
Loa Loa (eye worm) hypothetical protein 0.0052 0.0229 0.0226
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.0196 0.0869
Trichomonas vaginalis D-aminoacylase, putative 0.014 0.0759 0.3883
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.014 0.0759 0.0756
Schistosoma mansoni methyl-cpg binding protein mbd 0.0033 0.0117 0.0117
Echinococcus multilocularis expressed conserved protein 0.0131 0.0706 0.0702
Toxoplasma gondii histone lysine-specific demethylase 0.0025 0.007 0.0308
Loa Loa (eye worm) CXXC zinc finger family protein 0.0085 0.0426 0.0423
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0121 0.0647 0.1874
Trypanosoma brucei phosphoglycerate kinase 0.033 0.1904 0.5516
Echinococcus multilocularis expressed protein 0.0025 0.0068 0.0065
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.004 0.0029
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0243 0.1379 0.7238
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0043 0.0178 0.0881
Loa Loa (eye worm) steroid hormone receptor 0.003 0.01 0.0096
Loa Loa (eye worm) phosphofructokinase 0.0106 0.0556 0.0553
Leishmania major UDP-galactopyranose mutase 0.0025 0.007 0.0196
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0012 0.0002
Entamoeba histolytica diacylglycerol kinase, putative 0.0065 0.031 0.031
Toxoplasma gondii diacylglycerol kinase, putative 0.0065 0.031 0.1581
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0022 0.0051 0.0047
Loa Loa (eye worm) hypothetical protein 0.0025 0.007 0.0066
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0027 0.0078 0.0355
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0116 0.0614 0.0603
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0468 0.0465
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0121 0.0647 0.1874
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0212 0.0201
Loa Loa (eye worm) hypothetical protein 0.0091 0.0465 0.0462
Mycobacterium ulcerans hypothetical protein 0.0069 0.0335 0.0296
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0012 0.0012
Echinococcus granulosus dnaJ subfamily B 0.1204 0.7164 0.7163
Schistosoma mansoni apoferritin-2 0.0025 0.0068 0.0068
Leishmania major hypothetical protein, conserved 0.003 0.0096 0.0273
Schistosoma mansoni ap endonuclease 0.0056 0.0252 0.0252
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.01 0.0096
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.1147 0.1144
Schistosoma mansoni bromodomain containing protein 0.0131 0.0706 0.0706
Echinococcus multilocularis ferritin 0.0025 0.0068 0.0065
Entamoeba histolytica recQ family helicase, putative 0.0035 0.0126 0.0126
Trypanosoma brucei DNA polymerase kappa, putative 0.0154 0.0847 0.2437
Echinococcus granulosus dna polymerase kappa 0.0154 0.0847 0.0844
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0113 0.011
Trypanosoma brucei acetyl-CoA synthetase, putative 0.002 0.004 0.0084
Schistosoma mansoni acetyl-CoA synthetase 0.002 0.004 0.004
Plasmodium falciparum DNA repair protein REV1, putative 0.0032 0.011 0.0577
Loa Loa (eye worm) hypothetical protein 0.0243 0.1379 0.1376
Trypanosoma cruzi DNA polymerase eta, putative 0.0081 0.0407 0.1177
Entamoeba histolytica acyl-CoA synthetase, putative 0.0069 0.0335 0.0335
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.0556 0.0553
Trypanosoma brucei phosphoglycerate kinase 0.0121 0.0647 0.1852
Treponema pallidum phosphoglycerate kinase 0.033 0.1904 1
Schistosoma mansoni phosphoglycerate kinase 0.033 0.1904 0.1904
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.001
Brugia malayi exodeoxyribonuclease III family protein 0.0056 0.0252 0.1309
Loa Loa (eye worm) hypothetical protein 0.0027 0.0078 0.0075
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.0556 0.2796
Loa Loa (eye worm) hypothetical protein 0.014 0.0759 0.0756
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0011 0.0011
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0027 0.0082 0.0078
Trypanosoma cruzi DNA damage repair protein, putative 0.0032 0.011 0.0313
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0121 0.0647 0.1874
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.042 0.1192
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.0158 0.087 0.0867
Echinococcus multilocularis intestinal type alkaline phosphatase 0.0158 0.087 0.0867
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0359 0.2075 0.2043
Entamoeba histolytica hypothetical protein 0.0035 0.0131 0.0131
Schistosoma mansoni coup transcription factor 0.003 0.01 0.01
Echinococcus granulosus bloom syndrome protein 0.0065 0.0307 0.0304
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0014 0.0014
Trichomonas vaginalis D-aminoacylase, putative 0.014 0.0759 0.3883
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0128 0.0688 0.1994
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0109 0.0309
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0082 0.0413 0.1195
Trypanosoma brucei unspecified product 0.0142 0.077 0.2212
Echinococcus granulosus FTZ F1 alpha 0.003 0.01 0.0096
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0056 0.0252 0.0249
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0027 0.0078 0.0075
Echinococcus multilocularis ceramide kinase 0.0065 0.031 0.0307
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0012 0.0008
Echinococcus multilocularis sentrin specific protease 7 0.0143 0.0781 0.0778
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.01 0.0096
Schistosoma mansoni hypothetical protein 0.03 0.1722 0.1722
Brugia malayi Eye-specific diacylglycerol kinase 0.0065 0.031 0.1615
Entamoeba histolytica hypothetical protein 0.0035 0.0131 0.0131
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0106 0.0556 0.2656
Brugia malayi RNA binding protein 0.0062 0.0288 0.1497
Brugia malayi polk-prov protein 0.0084 0.042 0.2193
Trypanosoma cruzi UDP-galactopyranose mutase 0.0025 0.007 0.0196
Schistosoma mansoni ferritin 0.0025 0.0068 0.0068
Entamoeba histolytica phosphoglycerate kinase, putative 0.033 0.1904 0.1904
Brugia malayi nuclear hormone receptor 0.003 0.01 0.0506
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0146 0.0796 0.0793
Mycobacterium tuberculosis Conserved hypothetical protein 0.0308 0.1774 0.1765
Loa Loa (eye worm) hypothetical protein 0.014 0.0759 0.0756
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0131 0.0131
Onchocerca volvulus 0.0031 0.0104 0.0763
Onchocerca volvulus 0.003 0.01 0.0732
Echinococcus multilocularis geminin 0.0331 0.1912 0.1909
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0104 0.0488
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.0196 0.0869
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0203 0.02
Loa Loa (eye worm) glutaminase 0.0266 0.1518 0.1515
Onchocerca volvulus 0.0025 0.007 0.0504
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0082 0.0413 0.1195
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0045 0.0187 0.0928
Mycobacterium ulcerans glutaminase 0.0266 0.1518 0.1484
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0011 0.0008
Loa Loa (eye worm) hypothetical protein 0.033 0.1904 0.1901
Trypanosoma cruzi hypothetical protein, conserved 0.014 0.0759 0.2201
Loa Loa (eye worm) PHD-finger family protein 0.004 0.0158 0.0155
Loa Loa (eye worm) hypothetical protein 0.0052 0.0229 0.0226
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0014
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.002 0.004 0.0029
Loa Loa (eye worm) ceramide kinase 0.0065 0.031 0.0307
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0033 0.00000000035446
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0288 0.0288
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.01 0.0506
Loa Loa (eye worm) hypothetical protein 0.0025 0.007 0.0066
Loa Loa (eye worm) hypothetical protein 0.0025 0.007 0.0066
Loa Loa (eye worm) diacylglycerol kinase 2 0.0065 0.031 0.0307
Mycobacterium tuberculosis Conserved protein 0.1676 1 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0011 0.0026
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0012 0.0001
Schistosoma mansoni zinc finger protein 0.003 0.0096 0.0096
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0082 0.0413 0.1195
Toxoplasma gondii hypothetical protein 0.0094 0.0486 0.2509
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0277 0.1585 0.4603
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.009 0.0473
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0052 0.0229 0.087
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.002 0.004 0.0029
Schistosoma mansoni cpg binding protein 0.0093 0.0478 0.0478
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.009 0.0306
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.033 0.1904 0.1894
Plasmodium vivax acetyl-CoA synthetase, putative 0.002 0.004 0.0152
Loa Loa (eye worm) hypothetical protein 0.003 0.01 0.0096
Schistosoma mansoni jumonji domain containing protein 0.0059 0.027 0.027
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0082 0.0413 0.1172
Trichomonas vaginalis phosphoglycerate kinase, putative 0.033 0.1904 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0124 0.0664 0.0661
Echinococcus multilocularis alkaline phosphatase 0.0158 0.087 0.0867
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.002 0.004 0.0029
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.0422 0.1196
Echinococcus granulosus sentrin specific protease 7 0.0143 0.0781 0.0778
Trypanosoma brucei hypothetical protein, conserved 0.014 0.0759 0.2181
Loa Loa (eye worm) beta-lactamase 0.014 0.0759 0.0756
Loa Loa (eye worm) hypothetical protein 0.0065 0.031 0.0307
Toxoplasma gondii histone lysine methyltransferase SET1 0.0169 0.0936 0.4889
Trypanosoma cruzi hypothetical protein, conserved 0.014 0.0759 0.2201
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.011 0.0313
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.002 0.004 0.0029
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0011 0.0008
Mycobacterium ulcerans hypothetical protein 0.0032 0.011 0.007
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.01 0.0506
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0069 0.0335 0.158
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0243 0.0243
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0012 0.0008
Brugia malayi Bromodomain containing protein 0.0078 0.0385 0.201
Mycobacterium leprae Probable lipase LipE 0.014 0.0759 0.386
Schistosoma mansoni thyroid hormone receptor 0.003 0.01 0.01
Loa Loa (eye worm) MBCTL1 0.0054 0.0243 0.024
Trypanosoma brucei DNA polymerase kappa, putative 0.0116 0.0614 0.1757
Trypanosoma brucei DNA polymerase kappa, putative 0.0154 0.0847 0.2437
Brugia malayi hypothetical protein 0.0016 0.0014 0.0054
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0027 0.0078 0.0395
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0288 0.0285
Loa Loa (eye worm) hypothetical protein 0.002 0.004 0.0037
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0033 0.00000000035446
Toxoplasma gondii diacylglycerol kinase accessory domain (presumed) domain-containing protein 0.0065 0.031 0.1581
Loa Loa (eye worm) hypothetical protein 0.0025 0.007 0.0066
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0011 0.0008
Schistosoma mansoni ferritin 0.0025 0.0068 0.0068
Leishmania major DNA polymerase eta, putative 0.0081 0.0407 0.1177
Trypanosoma brucei DNA polymerase kappa, putative 0.0154 0.0847 0.2437
Brugia malayi Pre-SET motif family protein 0.0031 0.0104 0.0527
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0014 0.0054
Brugia malayi Steroid receptor seven-up type 2 0.003 0.01 0.0506
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0128 0.0688 0.0685
Schistosoma mansoni alkaline phosphatase 0.0158 0.087 0.087
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0025 0.0068 0.0057
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0124 0.0664 0.0661
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0056 0.0252 0.0727
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0243 0.1379 0.1376
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0128 0.0688 0.1994
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.01 0.0096
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.0422 0.1196
Loa Loa (eye worm) hypothetical protein 0.014 0.0759 0.0756
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0077 0.038 0.0377
Echinococcus multilocularis sphingosine kinase 1 0.1676 1 1
Plasmodium vivax SET domain protein, putative 0.0031 0.0104 0.0488
Brugia malayi diacylglycerol kinase 0.0065 0.031 0.1615
Loa Loa (eye worm) hypothetical protein 0.014 0.0759 0.0756
Schistosoma mansoni glutaminase 0.0266 0.1518 0.1518
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.0196 0.0974
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0033 0.00000000035446
Trichomonas vaginalis penicillin-binding protein, putative 0.014 0.0759 0.3883
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.01 0.0096
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.027 0.0267
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0069 0.0335 0.0324
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.014 0.0759 0.0722
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.0556 0.161
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0052 0.0229 0.019
Echinococcus multilocularis transcription factor Dp 1 0.0074 0.0364 0.036
Loa Loa (eye worm) AMP-binding enzyme family protein 0.002 0.004 0.0037
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.007 0.0337 0.0334
Brugia malayi ImpB/MucB/SamB family protein 0.0103 0.0537 0.2808
Schistosoma mansoni hypothetical protein 0.0077 0.038 0.038
Schistosoma mansoni jumonji/arid domain-containing protein 0.0067 0.0321 0.0321
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0303 0.0303
Echinococcus multilocularis 0.0025 0.007 0.0066
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.011 0.0313
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.0158 0.087 0.0867
Leishmania major 4-coumarate:coa ligase-like protein 0.0069 0.0335 0.0966
Mycobacterium ulcerans lipase LipD 0.014 0.0759 0.0722
Onchocerca volvulus 0.014 0.0759 0.576
Leishmania major mitochondrial DNA polymerase beta 0.0586 0.3442 1
Loa Loa (eye worm) bromodomain containing protein 0.0038 0.0145 0.0141
Brugia malayi AMP-binding enzyme family protein 0.0069 0.0335 0.1742
Schistosoma mansoni ferritin light chain 0.0025 0.0068 0.0068
Trichomonas vaginalis sphingosine kinase, putative 0.0065 0.031 0.1483
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.014 0.0759 0.0759
Echinococcus granulosus ferritin 0.0025 0.0068 0.0065
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0203 0.0203
Echinococcus multilocularis neuropeptide s receptor 0.0451 0.2633 0.263
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.0556 0.0556
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0014 0.0014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.01 0.0096
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0109 0.0109
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.009 0.0306
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.027 0.0267
Trypanosoma brucei diacylglycerol kinase, putative 0.0065 0.031 0.0872
Plasmodium vivax acyl-CoA synthetase, putative 0.0052 0.0229 0.1151
Mycobacterium tuberculosis Conserved protein 0.014 0.0759 0.0749
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0077 0.038 0.0377
Schistosoma mansoni DNA polymerase eta 0.0152 0.0834 0.0834
Trypanosoma brucei Diacylglycerol kinase catalytic domain containing protein, putative 0.0065 0.031 0.0872
Mycobacterium tuberculosis Probable lipase LipE 0.014 0.0759 0.0749
Schistosoma mansoni ferritin 0.0025 0.0068 0.0068
Loa Loa (eye worm) acetyltransferase 0.0146 0.0796 0.0793
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.001
Mycobacterium tuberculosis Probable esterase LipL 0.014 0.0759 0.0749
Trichomonas vaginalis ferritin, putative 0.0025 0.0068 0.019
Brugia malayi acetyl-Coenzyme A synthetase 2 0.002 0.004 0.0193
Echinococcus granulosus zinc finger protein 0.0046 0.0196 0.0193
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0104 0.0104
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0069 0.0335 0.0296
Schistosoma mansoni hypothetical protein 0.1204 0.7164 0.7164
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0014 0.0054
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.01 0.0096
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.027 0.0267
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.0158 0.087 0.0867
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0288 0.0288
Schistosoma mansoni diacylglycerol kinase theta 0.0065 0.031 0.031
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0008
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0104 0.01
Onchocerca volvulus Bile acid receptor homolog 0.003 0.01 0.0732
Echinococcus multilocularis neuropeptide receptor A26 0.0451 0.2633 0.263
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.0556 0.0556
Leishmania major acetyl-CoA synthetase, putative 0.002 0.004 0.011
Brugia malayi hypothetical protein 0.0065 0.031 0.1615
Trypanosoma brucei phosphoglycerate kinase, putative 0.0121 0.0647 0.1852
Leishmania major hypothetical protein, conserved 0.0065 0.031 0.0896
Trypanosoma cruzi phosphoglycerate kinase, putative 0.033 0.1904 0.5528
Schistosoma mansoni apoferritin-2 0.0025 0.0068 0.0068
Giardia lamblia Phosphoglycerate kinase 0.033 0.1904 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.002 0.004 0.0037
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0121 0.0647 0.1874
Leishmania major ATP-dependent phosphofructokinase 0.0106 0.0556 0.161
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.0422 0.1196
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0056 0.0252 0.1325
Trypanosoma brucei DNA polymerase kappa, putative 0.0154 0.0847 0.2437
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0143 0.0781 0.0781
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.009 0.0306
Brugia malayi mbt repeat family protein 0.0047 0.0203 0.1052
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.009 0.0417
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0022 0.0051 0.0047
Trypanosoma brucei DNA polymerase kappa, putative 0.0154 0.0847 0.2437
Loa Loa (eye worm) latrophilin receptor protein 2 0.0077 0.038 0.0377
Brugia malayi amine oxidase, flavin-containing family protein 0.0025 0.007 0.0348
Loa Loa (eye worm) hypothetical protein 0.0065 0.031 0.0307
Mycobacterium ulcerans hypothetical protein 0.014 0.0759 0.0722
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.001
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0154 0.0847 0.4353
Trypanosoma brucei DNA polymerase kappa, putative 0.0154 0.0847 0.2437
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0012 0.0008
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0116 0.0614 0.1778
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.033 0.1904 1
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0035 0.0126 0.0359
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0003 0.0003
Brugia malayi latrophilin 2 splice variant baaae 0.0166 0.0916 0.4805
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.0468 0.2447
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0024 0.0063 0.0059
Trypanosoma cruzi DNA damage repair protein, putative 0.0032 0.011 0.0313
Leishmania major phosphoglycerate kinase B, cytosolic 0.033 0.1904 0.5528
Mycobacterium ulcerans dehydrogenase 0.0025 0.007 0.003
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.002 0.004 0.011
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.002 0.004 0.0084
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.042 0.1192
Schistosoma mansoni hypothetical protein 0.0065 0.031 0.031
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.01 0.0096
Brugia malayi ecdysteroid receptor 0.003 0.01 0.0506
Loa Loa (eye worm) hypothetical protein 0.0065 0.031 0.0307
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.003 0.0101 0.0472
Schistosoma mansoni bromodomain containing protein 0.0017 0.0017 0.0017
Trichomonas vaginalis DNA polymerase eta, putative 0.0154 0.0847 0.4353
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.01 0.01
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0011 0.0008
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0027 0.0078 0.0075
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0035 0.0126 0.0359
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.01 0.0506
Echinococcus multilocularis protoporphyrinogen oxidase 0.0025 0.007 0.0066
Onchocerca volvulus 0.0069 0.0335 0.2523
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.009 0.0064
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0128 0.0688 0.0685
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.0196 0.0974
Brugia malayi AMP-binding enzyme family protein 0.002 0.004 0.0193
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.01 0.01
Mycobacterium ulcerans 6-phosphofructokinase 0.0106 0.0556 0.0518
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0212 0.0201
Echinococcus granulosus GPCR family 2 0.0077 0.038 0.0377
Giardia lamblia DINP protein human, muc B family 0.0116 0.0614 0.2934
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.01 0.0096
Mycobacterium ulcerans DNA polymerase IV 0.0154 0.0847 0.081
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0008
Trichomonas vaginalis antibiotic synthetase, putative 0.002 0.004 0.0038
Schistosoma mansoni jumonji/arid domain-containing protein 0.0067 0.0321 0.0321
Brugia malayi jmjC domain containing protein 0.0016 0.0012 0.0043
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.009 0.0306
Loa Loa (eye worm) hypothetical protein 0.0064 0.0303 0.0299
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.01 0.0096
Trypanosoma cruzi phosphoglycerate kinase, putative 0.033 0.1904 0.5528
Trichomonas vaginalis rotamase, putative 0.0033 0.0113 0.0429
Brugia malayi Calcitonin receptor-like protein seb-1 0.0243 0.1379 0.7238
Brugia malayi Latrophilin receptor protein 2 0.0077 0.038 0.1982
Trichomonas vaginalis DNA helicase recq1, putative 0.0065 0.0307 0.1466
Echinococcus multilocularis Diacylglycerol kinase zeta 0.0065 0.031 0.0307
Brugia malayi isocitrate dehydrogenase 0.0016 0.0011 0.0041
Trichomonas vaginalis D-aminoacylase, putative 0.014 0.0759 0.3883
Echinococcus multilocularis FTZ F1 alpha 0.003 0.01 0.0096
Loa Loa (eye worm) RNA binding protein 0.0062 0.0288 0.0285
Loa Loa (eye worm) hypothetical protein 0.0025 0.007 0.0066
Trichomonas vaginalis antibiotic synthetase, putative 0.002 0.004 0.0038
Loa Loa (eye worm) RecQ helicase 0.0065 0.0307 0.0304
Onchocerca volvulus 0.0047 0.0203 0.1523
Brugia malayi jmjC domain containing protein 0.0016 0.0012 0.0043
Schistosoma mansoni ap endonuclease 0.0056 0.0252 0.0252
Brugia malayi TAR-binding protein 0.0062 0.0288 0.1497
Trypanosoma brucei ISWI complex protein 0.003 0.0096 0.0248
Plasmodium vivax DNA repair protein REV1, putative 0.0032 0.011 0.0521
Mycobacterium ulcerans bacterioferritin BfrB 0.0025 0.0068 0.0029
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0022 0.0051 0.0047
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0288 0.0288
Leishmania major hypothetical protein, conserved 0.014 0.0759 0.2201
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0128 0.0688 0.0685
Plasmodium vivax hypothetical protein, conserved 0.0025 0.007 0.0308
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.01 0.01
Schistosoma mansoni hypothetical protein 0.003 0.0096 0.0096
Entamoeba histolytica diacylglycerol kinase, putative 0.0065 0.031 0.031
Trichomonas vaginalis esterase, putative 0.014 0.0759 0.3883
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0277 0.1585 0.4603
Entamoeba histolytica hypothetical protein, conserved 0.1676 1 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.01 0.0096
Trypanosoma cruzi DNA polymerase kappa, putative 0.0154 0.0847 0.2457
Trypanosoma brucei Sphingosine kinase 0.0065 0.031 0.0872
Mycobacterium ulcerans bacterioferritin BfrA 0.0025 0.0068 0.0029
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0065 0.031 0.1483
Schistosoma mansoni rotamase 0.0033 0.0113 0.0113
Schistosoma mansoni nuclear hormone receptor 0.003 0.01 0.01
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.009 0.0306
Brugia malayi nuclear receptor NHR-88 0.003 0.01 0.0506
Toxoplasma gondii exonuclease III APE 0.0056 0.0252 0.1273
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0012 0.0008
Leishmania major 4-coumarate:coa ligase-like protein 0.0069 0.0335 0.0966
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0012 0.0008
Onchocerca volvulus 0.0065 0.031 0.2339
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.01 0.0506
Mycobacterium tuberculosis Possible oxidoreductase 0.0025 0.007 0.0058
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0012 0.0027
Schistosoma mansoni thyroid hormone receptor 0.003 0.01 0.01
Echinococcus multilocularis dna polymerase kappa 0.0154 0.0847 0.0844
Plasmodium falciparum phosphoglycerate kinase 0.033 0.1904 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.007 0.0066
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0022 0.0051 0.0051
Trichomonas vaginalis DNA helicase recq, putative 0.0065 0.0307 0.1466
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0056 0.0252 0.0952
Plasmodium falciparum JmjC domain-containing protein, putative 0.0016 0.0012 0.0061
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0288 0.0288
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0128 0.0688 0.0688
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0069 0.0335 0.0296
Schistosoma mansoni phosphoglycerate kinase 0.033 0.1904 0.1904
Schistosoma mansoni amine oxidase 0.0025 0.007 0.007
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.0556 0.2796
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.002 0.004 0.011
Toxoplasma gondii phosphoglycerate kinase PGKII 0.033 0.1904 1
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0277 0.1585 0.4589
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.0158 0.087 0.0867
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0069 0.0335 0.0296
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.01 0.0506
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0025 0.007 0.0159
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0104 0.0104
Onchocerca volvulus 0.002 0.004 0.0279
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0049 0.021 0.0206
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.01 0.0096
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.002 0.004 0.011
Mycobacterium tuberculosis Conserved protein 0.014 0.0759 0.0749
Plasmodium falciparum protoporphyrinogen oxidase 0.0025 0.007 0.0366
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.01 0.01
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0064 0.0303 0.0299
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0018 0.0023 0.0012
Trypanosoma cruzi ISWI complex protein 0.003 0.0096 0.0273
Brugia malayi Pre-SET motif family protein 0.0204 0.1147 0.6021
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0008
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.0556 0.1588
Plasmodium vivax JmjC domain containing protein 0.0016 0.0012 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.031 0.1483
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.01 0.0096
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0056 0.0252 0.1001
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0014 0.001
Onchocerca volvulus Ceramide kinase 1 homolog 0.0065 0.031 0.2339
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.01 0.0506
Loa Loa (eye worm) hypothetical protein 0.0077 0.038 0.0377
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0106 0.0556 0.2768
Loa Loa (eye worm) hypothetical protein 0.0082 0.0414 0.0411
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0049 0.021 0.021
Schistosoma mansoni cpg binding protein 0.0093 0.0478 0.0478
Loa Loa (eye worm) hypothetical protein 0.003 0.01 0.0096
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0032 0.011 0.0521
Brugia malayi mbt repeat family protein 0.0047 0.0203 0.1052
Schistosoma mansoni hypothetical protein 0.0077 0.038 0.038
Brugia malayi hypothetical protein 0.0035 0.0131 0.067
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0128 0.0688 0.3602
Echinococcus granulosus ceramide kinase 0.0065 0.031 0.0307
Leishmania major phosphoglycerate kinase C, glycosomal 0.033 0.1904 0.5528
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.002 0.004 0.0029
Entamoeba histolytica hypothetical protein 0.0035 0.0131 0.0131
Schistosoma mansoni diacylglycerol kinase zeta iota 0.0065 0.031 0.031
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.009 0.0306
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0894 0.5295 0.5289
Brugia malayi SWIRM domain containing protein 0.0025 0.007 0.0348
Entamoeba histolytica deoxycytidyl transferase, putative 0.0103 0.0537 0.0537
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.002 0.004 0.011
Echinococcus granulosus lysine specific histone demethylase 1A 0.0025 0.007 0.0066
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.01 0.01
Trypanosoma brucei DNA polymerase kappa, putative 0.0154 0.0847 0.2437
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0056 0.0252 0.0249
Brugia malayi Bromodomain containing protein 0.0154 0.0843 0.4417
Trypanosoma cruzi diacylglycerol kinase, putative 0.0065 0.031 0.0896
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0014 0.001
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0106 0.0556 0.0545
Echinococcus granulosus Diacylglycerol kinase theta 0.0065 0.031 0.0307
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0025 0.007 0.0308
Trypanosoma brucei hypothetical protein, conserved 0.0032 0.011 0.0287
Echinococcus granulosus expressed protein 0.0033 0.0113 0.011
Echinococcus multilocularis Diacylglycerol kinase theta 0.0065 0.031 0.0307
Mycobacterium ulcerans beta-lactamase 0.014 0.0759 0.0722
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0027 0.0078 0.0412
Schistosoma mansoni amine oxidase 0.0025 0.007 0.007
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0128 0.0688 0.0688
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0056 0.0252 0.0213
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.01 0.0732
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0012 0.0008
Echinococcus multilocularis bloom syndrome protein 0.0065 0.0307 0.0304
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0033 0.00000000035446
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.009 0.0473
Trypanosoma cruzi hypothetical protein, conserved 0.0065 0.031 0.0896
Trypanosoma cruzi DNA polymerase kappa, putative 0.0154 0.0847 0.2457
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.01 0.0506
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0044 0.0181 0.0897
Loa Loa (eye worm) hypothetical protein 0.0047 0.0203 0.02
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0056 0.0252 0.0702
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0012 0.0008
Brugia malayi Phosphoglycerate kinase 0.0121 0.0647 0.3385
Schistosoma mansoni zinc finger protein 0.0014 0.0003 0.0003
Trichomonas vaginalis rotamase, putative 0.0032 0.0109 0.0405
Plasmodium vivax diacylglycerol kinase, putative 0.0065 0.031 0.1581
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.0109 0.0284
Trypanosoma brucei DNA polymerase eta, putative 0.0152 0.0834 0.2399
Loa Loa (eye worm) hypothetical protein 0.003 0.01 0.0096
Brugia malayi F/Y-rich N-terminus family protein 0.0031 0.0102 0.0518
Echinococcus granulosus expressed conserved protein 0.0131 0.0706 0.0702
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0333 0.1923 0.1914
Loa Loa (eye worm) hypothetical protein 0.0137 0.0743 0.074
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0012 0.0008
Plasmodium falciparum diacylglycerol kinase, putative 0.0065 0.031 0.1631
Schistosoma mansoni cpg binding protein 0.0085 0.0426 0.0426
Schistosoma mansoni nuclear receptor nhr-48 0.0014 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0069 0.0335 0.0331
Schistosoma mansoni hypothetical protein 0.0035 0.0131 0.0131
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0012 0.0027
Treponema pallidum exodeoxyribonuclease (exoA) 0.0056 0.0252 0.1001
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.0556 0.2796
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0012 0.0012
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0011 0.0008
Echinococcus granulosus neuropeptide receptor A26 0.0451 0.2633 0.263
Echinococcus multilocularis expressed protein 0.0033 0.0113 0.011
Echinococcus granulosus Diacylglycerol kinase zeta 0.0065 0.031 0.0307
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0288 0.0285
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0203 0.0203
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.01 0.0506
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0012 0.0012
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0027 0.0078 0.0075
Chlamydia trachomatis phosphoglycerate kinase 0.033 0.1904 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.009 0.0118
Schistosoma mansoni sphingosine kinase A B 0.1676 1 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.007 0.0337 0.0334
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.0625 0.0622
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0103 0.0537 0.0534
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0027 0.0078 0.0355
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0035 0.0126 0.0334
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0057 0.026 0.1365
Trypanosoma brucei unspecified product 0.0071 0.0345 0.0972
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0024 0.0063 0.0059
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.009 0.0417
Brugia malayi Ceramide kinase 0.0065 0.031 0.1615
Leishmania major DNA polymerase eta, putative 0.0152 0.0834 0.2419
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.01 0.0096
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0113 0.0578
Schistosoma mansoni hypothetical protein 0.0082 0.0412 0.0412
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0012 0.0008
Leishmania major sphingosine kinase A, B, putative 0.0065 0.031 0.0896
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0103 0.0537 0.0537
Leishmania major hypothetical protein, conserved 0.0016 0.0012 0.0027
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0468 0.0465
Loa Loa (eye worm) hypothetical protein 0.003 0.01 0.0096
Plasmodium falciparum acetyl-CoA synthetase, putative 0.002 0.004 0.021
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.002 0.004 0.0037
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.009 0.0112
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.014 0.0759 0.0749
Echinococcus granulosus lysine specific demethylase 5A 0.0067 0.0321 0.0318
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0025 0.007 0.007
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0212 0.0201
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.01 0.01
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0056 0.0252 0.0241
Trypanosoma brucei unspecified product 0.0071 0.0345 0.0972
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.01 0.0096
Leishmania major DNA polymerase kappa, putative 0.0116 0.0614 0.1778
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0109 0.0309
Mycobacterium tuberculosis Conserved hypothetical protein 0.0103 0.0537 0.0526
Onchocerca volvulus 0.014 0.0759 0.576
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0121 0.0647 0.1874
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.01 0.0732
Toxoplasma gondii ABC1 family protein 0.014 0.0759 0.3953
Leishmania major diacylglycerol kinase-like protein 0.0065 0.031 0.0896
Brugia malayi hypothetical protein 0.0016 0.0014 0.0054
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0212 0.0201
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0468 0.0468
Echinococcus granulosus tar DNA binding protein 0.0062 0.0288 0.0285
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.01 0.0096
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0065 0.031 0.031
Mycobacterium ulcerans monoamine oxidase 0.0025 0.007 0.003
Schistosoma mansoni sphingoid long chain base kinase 0.1676 1 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0056 0.0252 0.0727
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0143 0.0781 0.0781
Trypanosoma cruzi DNA polymerase eta, putative 0.0152 0.0834 0.2419
Toxoplasma gondii propionate-CoA ligase 0.002 0.004 0.0152
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0468 0.0468
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0303 0.0303
Schistosoma mansoni hypothetical protein 0.004 0.0158 0.0158
Echinococcus granulosus geminin 0.0331 0.1912 0.1909
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.014 0.0759 0.3978
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0012 0.0002
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.009 0.0417
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0014 0.0003 0.0003
Brugia malayi steroid hormone receptor 0.003 0.01 0.0506
Trichomonas vaginalis bmru protein, putative 0.0065 0.031 0.1483
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0243 0.024
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.004 0.0029
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0203 0.02
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.01 0.0096
Trypanosoma brucei DNA polymerase IV, putative 0.0142 0.077 0.2212
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0033 0.00000000035446
Schistosoma mansoni hypothetical protein 0.0077 0.038 0.038
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0033 0.0117 0.0113
Brugia malayi glutaminase DH11.1 0.0266 0.1518 0.7973
Loa Loa (eye worm) hypothetical protein 0.1676 1 1
Brugia malayi jmjC domain containing protein 0.0059 0.027 0.1402
Plasmodium vivax hypothetical protein, conserved 0.014 0.0759 0.3953
Trypanosoma brucei hypothetical protein, conserved 0.0032 0.011 0.0287
Giardia lamblia DNA damage repair protein 0.0032 0.011 0.0172
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0056 0.0252 0.0727
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0025 0.007 0.0366
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.002 0.004 0.0029
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.01 0.0506
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0203 0.02
Mycobacterium ulcerans acyl-CoA synthetase 0.0069 0.0335 0.0296
Brugia malayi 6-phosphofructokinase 0.0106 0.0556 0.2908
Echinococcus granulosus acylglycerol kinase mitochondrial 0.0065 0.031 0.0307
Trypanosoma cruzi ISWI complex protein 0.003 0.0096 0.0273
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0121 0.0647 0.1874
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.01 0.0096
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.0556 0.0556
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.002 0.004 0.0029
Brugia malayi Bloom's syndrome protein homolog 0.0065 0.0307 0.1599
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0077 0.038 0.1982
Trichomonas vaginalis diacylglycerol kinase, epsilon, putative 0.0065 0.031 0.1483
Schistosoma mansoni diacylglycerol kinase theta 0.0065 0.031 0.031
Leishmania major diacylglycerol kinase, putative 0.0065 0.031 0.0896
Trypanosoma brucei DNA damage repair protein, putative 0.0032 0.011 0.0287
Echinococcus multilocularis beta LACTamase domain containing family member 0.014 0.0759 0.0756
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0077 0.038 0.0377
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.002 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0054 0.0243 0.024
Echinococcus multilocularis dnaJ subfamily B 0.1204 0.7164 0.7163
Toxoplasma gondii diacylglycerol kinase catalytic domain-containing protein 0.0065 0.031 0.1581
Echinococcus multilocularis zinc finger protein 0.0046 0.0196 0.0193
Plasmodium vivax hypothetical protein, conserved 0.0025 0.007 0.0308
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.009 0.009
Echinococcus granulosus mixed lineage leukemia protein mll 0.0022 0.0051 0.0047
Brugia malayi AMP-binding enzyme family protein 0.0069 0.0335 0.1742
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.009 0.0417
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.004 0.0029
Loa Loa (eye worm) hypothetical protein 0.0052 0.0229 0.0226
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0025 0.007 0.0066
Trichomonas vaginalis ap endonuclease, putative 0.0056 0.0252 0.1172
Echinococcus granulosus phd:f box containing protein 0.0016 0.0012 0.0008
Mycobacterium leprae conserved hypothetical protein 0.014 0.0759 0.386
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0468 0.0468
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.004 0.0193
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.033 0.1904 1
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0025 0.007 0.007
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0288 0.0288
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0203 0.02
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.01 0.0506
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0065 0.031 0.0896
Brugia malayi jmjC domain containing protein 0.0067 0.0321 0.1672
Loa Loa (eye worm) hypothetical protein 0.014 0.0759 0.0756
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0586 0.3442 1
Loa Loa (eye worm) hypothetical protein 0.003 0.01 0.0096
Loa Loa (eye worm) glutaminase 2 0.0266 0.1518 0.1515
Trypanosoma brucei DNA polymerase kappa, putative 0.0154 0.0847 0.2437
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0011 0.0008
Echinococcus multilocularis phosphoglycerate kinase 1 0.033 0.1904 0.1901
Loa Loa (eye worm) hypothetical protein 0.014 0.0759 0.0756
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0027 0.0078 0.0395
Loa Loa (eye worm) hypothetical protein 0.0052 0.0229 0.0226
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.002 0.004 0.0152
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0012 0.0012
Echinococcus granulosus expressed protein 0.0025 0.0068 0.0065
Schistosoma mansoni DNA polymerase IV / kappa 0.0032 0.011 0.011
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0033 0.00000000035446
Loa Loa (eye worm) hypothetical protein 0.0069 0.0335 0.0331
Echinococcus granulosus phosphoglycerate kinase 1 0.033 0.1904 0.1901
Mycobacterium ulcerans phosphoglycerate kinase 0.033 0.1904 0.1871
Trypanosoma brucei DNA damage repair protein, putative 0.0032 0.011 0.0287
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0027 0.0078 0.0075
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0203 0.02
Entamoeba histolytica diacylglycerol kinase, putative 0.0065 0.031 0.031
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0103 0.0537 0.0534
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0069 0.0335 0.0296
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.004 0.0029
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.001
Brugia malayi AMP-binding enzyme family protein 0.002 0.004 0.0193
Plasmodium falciparum acyl-CoA synthetase 0.0052 0.0229 0.1204
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0131 0.0127
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.01 0.0096
Schistosoma mansoni mixed-lineage leukemia protein mll 0.018 0.1003 0.1003
Trypanosoma brucei hypothetical protein, conserved 0.0065 0.031 0.0872
Trypanosoma cruzi DNA polymerase kappa, putative 0.0154 0.0847 0.2457
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.0196 0.0192
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0586 0.3442 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.001
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0243 0.126
Loa Loa (eye worm) oxidoreductase 0.002 0.004 0.0037
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0243 0.024
Trichomonas vaginalis ap endonuclease, putative 0.0056 0.0252 0.1172
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.0468 0.0465
Trypanosoma cruzi diacylglycerol kinase, putative 0.0065 0.031 0.0896
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0147 0.0147
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0056 0.0252 0.0252
Entamoeba histolytica acyl-CoA synthetase, putative 0.0069 0.0335 0.0335
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0025 0.007 0.0366
Onchocerca volvulus 0.002 0.004 0.0279
Mycobacterium tuberculosis Diacylglycerol kinase 0.0065 0.031 0.0299
Echinococcus granulosus 6 phosphofructokinase 0.0106 0.0556 0.0553
Brugia malayi Diacylglycerol kinase protein 2 0.0065 0.031 0.1615
Onchocerca volvulus 0.0085 0.0426 0.3223
Brugia malayi CXXC zinc finger family protein 0.0085 0.0426 0.2226
Leishmania major DNA polymerase kappa, putative 0.0032 0.011 0.0313
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0011 0.0041
Loa Loa (eye worm) histone methyltransferase 0.0027 0.0082 0.0078
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0128 0.0688 0.1994
Brugia malayi jmjC domain containing protein 0.0016 0.0012 0.0043
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.01 0.01
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0288 0.1497
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.01 0.0096
Toxoplasma gondii phosphoglycerate kinase PGKI 0.033 0.1904 1
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0147 0.0773
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0586 0.3442 1
Brugia malayi MH2 domain containing protein 0.0118 0.0625 0.327
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0103 0.0537 0.0534
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0069 0.0335 0.158
Plasmodium falciparum diacylglycerol kinase, putative 0.0065 0.031 0.1631
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0033 0.00000000035446
Schistosoma mansoni nuclear receptor 0.0014 0.0003 0.0003
Trypanosoma brucei DNA polymerase IV, putative 0.0154 0.0847 0.2437
Schistosoma mansoni DNA helicase recq1 0.0027 0.0078 0.0078
Echinococcus granulosus alkaline phosphatase 0.0158 0.087 0.0867
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0014 0.0003 0.0003
Mycobacterium ulcerans oxidoreductase 0.0025 0.007 0.003
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0468 0.0465
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0288 0.0285
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0243 0.024
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.0745 0.0742
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0065 0.031 0.1483
Leishmania major hypothetical protein, conserved 0.0065 0.031 0.0896
Trypanosoma cruzi DNA polymerase kappa, putative 0.0154 0.0847 0.2457
Plasmodium vivax phosphoglycerate kinase, putative 0.033 0.1904 1
Trypanosoma cruzi Sphingosine kinase 0.0065 0.031 0.0896
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.002 0.004 0.0152
Onchocerca volvulus 0.002 0.004 0.0279
Echinococcus multilocularis 6 phosphofructokinase 0.0106 0.0556 0.0553
Loa Loa (eye worm) hypothetical protein 0.0152 0.0834 0.0831
Trypanosoma brucei phosphoglycerate kinase 0.033 0.1904 0.5516
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.0556 0.0553
Echinococcus granulosus beta LACTamase domain containing family member 0.014 0.0759 0.0756
Trypanosoma brucei chrX additional, unordered contigs 0.0032 0.011 0.0287
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.0109 0.0309
Trichomonas vaginalis DNA helicase recq, putative 0.0035 0.0126 0.0496
Schistosoma mansoni ferritin light chain 0.0025 0.0068 0.0068
Mycobacterium ulcerans esterase/lipase LipP 0.014 0.0759 0.0722
Trichomonas vaginalis glutaminase, putative 0.0266 0.1518 0.7941
Schistosoma mansoni methyl-cpg binding protein mbd 0.0033 0.0117 0.0117
Leishmania major acetyl-CoA synthetase, putative 0.002 0.004 0.011
Echinococcus granulosus histone lysine methyltransferase setb 0.0064 0.0303 0.0299
Brugia malayi 6-phosphofructokinase 0.0106 0.0556 0.2908
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0203 0.1523
Onchocerca volvulus 0.0232 0.1316 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.01 0.0096
Trichomonas vaginalis sphingosine kinase, putative 0.0065 0.031 0.1483
Mycobacterium ulcerans acyl-CoA synthetase 0.0069 0.0335 0.0296
Entamoeba histolytica hypothetical protein 0.0035 0.0131 0.0131
Schistosoma mansoni nuclear receptor 0.0014 0.0003 0.0003
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0027 0.0082 0.0078
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0012 0.0008
Mycobacterium tuberculosis Conserved protein 0.014 0.0759 0.0749
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0146 0.0796 0.0796
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.0556 0.2796
Loa Loa (eye worm) hypothetical protein 0.0084 0.042 0.0417
Schistosoma mansoni terminal deoxycytidyl transferase 0.0103 0.0537 0.0537
Schistosoma mansoni blooms syndrome DNA helicase 0.0051 0.0225 0.0225
Schistosoma mansoni DNA helicase recq5 0.0027 0.0078 0.0078
Echinococcus granulosus cpg binding protein 0.0093 0.0478 0.0474
Loa Loa (eye worm) hypothetical protein 0.0074 0.0365 0.0362
Loa Loa (eye worm) hypothetical protein 0.002 0.004 0.0037
Trichomonas vaginalis diacylglycerol kinase, putative 0.0065 0.031 0.1483
Mycobacterium tuberculosis Probable hydrolase 0.014 0.0759 0.0749
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0011 0.0059
Schistosoma mansoni hypothetical protein 0.0077 0.038 0.038
Schistosoma mansoni alkaline phosphatase 0.0158 0.087 0.087
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0011 0.0026
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0011 0.0008
Brugia malayi nuclear receptor RXR 0.0016 0.0014 0.0054
Mycobacterium ulcerans hypothetical protein 0.0308 0.1774 0.1741
Loa Loa (eye worm) hypothetical protein 0.003 0.01 0.0096
Loa Loa (eye worm) hypothetical protein 0.0166 0.0916 0.0913
Trypanosoma cruzi Diacylglycerol kinase catalytic domain containing protein, putative 0.0065 0.031 0.0896
Mycobacterium ulcerans hypothetical protein 0.1676 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.01 0.0096
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0033 0.00000000035446
Brugia malayi ImpB/MucB/SamB family protein 0.0152 0.0834 0.4372
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.01 0.0506
Trypanosoma brucei DNA polymerase kappa, putative 0.0154 0.0847 0.2437
Trichomonas vaginalis set domain proteins, putative 0.0232 0.1316 0.6858
Echinococcus multilocularis cpg binding protein 0.0093 0.0478 0.0474
Schistosoma mansoni zinc finger protein 0.0046 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.0052 0.0229 0.0226
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.0556 0.0556
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0081 0.0407 0.2092
Brugia malayi AMP-binding enzyme family protein 0.002 0.004 0.0193
Echinococcus granulosus transcription factor Dp 1 0.0074 0.0364 0.036
Trichomonas vaginalis diacylglycerol kinase, putative 0.0065 0.031 0.1483
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0077 0.038 0.0377
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0198 0.1111 0.1108
Mycobacterium tuberculosis Conserved hypothetical protein 0.0025 0.007 0.0058
Echinococcus multilocularis GPCR, family 2 0.0077 0.038 0.0377
Trypanosoma cruzi Sphingosine kinase 0.0065 0.031 0.0896
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0069 0.0335 0.0324
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0086 0.0083
Brugia malayi AMP-binding enzyme family protein 0.0069 0.0335 0.1742
Onchocerca volvulus 0.014 0.0759 0.576
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.009 0.0306
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0025 0.0068 0.0152
Echinococcus granulosus dna polymerase eta 0.0152 0.0834 0.0831
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0011 0.0026
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.014 0.0759 0.0749
Onchocerca volvulus 0.0024 0.0063 0.0452
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0147 0.0376
Brugia malayi beta-lactamase family protein 0.014 0.0759 0.3978
Loa Loa (eye worm) hypothetical protein 0.003 0.01 0.0096
Brugia malayi phosphofructokinase 0.0106 0.0556 0.2908
Brugia malayi diacylglycerol kinase 0.0065 0.031 0.1615
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0025 0.007 0.003
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.0196 0.0974
Echinococcus granulosus neuropeptide s receptor 0.0451 0.2633 0.263
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0131 0.0127
Echinococcus multilocularis acylglycerol kinase, mitochondrial 0.0065 0.031 0.0307
Brugia malayi beta-lactamase 0.014 0.0759 0.3978
Echinococcus granulosus fetal alzheimer antigen falz 0.0049 0.021 0.0206
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.0625 0.0622
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0359 0.2075 0.2043
Brugia malayi beta-lactamase family protein 0.014 0.0759 0.3978
Plasmodium vivax diacylglycerol kinase, putative 0.0065 0.031 0.1581
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0003 0.0003
Brugia malayi AMP-binding enzyme family protein 0.002 0.004 0.0193
Trichomonas vaginalis phosphoglycerate kinase, putative 0.033 0.1904 1
Brugia malayi Phosphoglycerate kinase 0.033 0.1904 1
Trypanosoma brucei DNA polymerase IV, putative 0.0154 0.0847 0.2437
Brugia malayi hypothetical protein 0.0025 0.007 0.0348
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0198 0.1111 0.1108
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.009 0.0417

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 14.27 nM Inhibition of recombinant human MAO-B using p-tyramine as substrate assessed as decrease in H2O2 production incubated for 15 mins by fluorimetric method LITERATURE. 27692996
IC50 (binding) = 0.0062 uM Inhibition of recombinant human MAO-B assessed as inhibition of kynuramine conversion to fluorescent metabolite 4-hydroxyquinoline after 20 mins by fluorescence spectrophotometry ChEMBL. 24012182
IC50 (binding) > 100 uM Inhibition of recombinant human MAO-A using p-tyramine as substrate assessed as decrease in H2O2 production incubated for 15 mins by fluorimetric method LITERATURE. 27692996
Inhibition (binding) Inhibition of recombinant human MAO-A assessed as inhibition of kynuramine conversion to fluorescent metabolite 4-hydroxyquinoline at 100 uM after 20 mins by fluorescence spectrophotometry ChEMBL. 24012182
Ratio IC50 (binding) = 14 Potency index, ratio of lazabemide IC50 to compound IC50 for recombinant human MAO-B ChEMBL. 24012182

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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