Detailed information for compound 1995087

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 470.584 | Formula: C25H36N5O4+
  • H donors: 1 H acceptors: 3 LogP: 5.27 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCOc1cc(cc(c1)C(C)(C)C)C(=O)C[n+]1nc(n2c1ccc(n2)OC(CC)CC)N
  • InChi: 1S/C25H36N5O4/c1-7-19(8-2)34-22-9-10-23-29(28-24(26)30(23)27-22)16-21(31)17-13-18(25(3,4)5)15-20(14-17)33-12-11-32-6/h9-10,13-15,19H,7-8,11-12,16H2,1-6H3,(H2,26,28)/q+1
  • InChiKey: VNGQUWHQKYVJDP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens coagulation factor II (thrombin) receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0023 0.0027 0.0024
Echinococcus granulosus histone lysine methyltransferase setb 0.0118 0.0442 0.0439
Trichomonas vaginalis D-aminoacylase, putative 0.0093 0.0332 0.0868
Echinococcus granulosus chromobox protein 1 0.0046 0.0126 0.0123
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0023 0.0024 0.0024
Mycobacterium ulcerans aldehyde dehydrogenase 0.0412 0.1725 0.9415
Plasmodium falciparum thioredoxin reductase 0.0036 0.0083 0.0271
Giardia lamblia Cathepsin B precursor 0.0171 0.0674 0.1709
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0118 0.0441 0.0438
Leishmania major cathepsin L-like protease 0.0688 0.2929 0.9576
Leishmania major hypothetical protein, conserved 0.0093 0.0332 0.1074
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0073 0.0244 0.024
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0688 0.2929 0.9576
Trichomonas vaginalis conserved hypothetical protein 0.0115 0.0427 0.1115
Giardia lamblia NADH oxidase lateral transfer candidate 0.0036 0.0083 0.0156
Trichomonas vaginalis chromobox protein, putative 0.0028 0.0046 0.0121
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0115 0.0427 0.1115
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.0053 0.0139
Loa Loa (eye worm) hypoxia-induced factor 1 0.0108 0.0398 0.0471
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0004 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0688 0.2929 0.7655
Giardia lamblia Cathepsin B precursor 0.0717 0.3058 0.7981
Echinococcus multilocularis muscleblind protein 0.02 0.08 0.0797
Loa Loa (eye worm) hypothetical protein 0.0688 0.2929 0.349
Mycobacterium tuberculosis Probable lipase LipE 0.0093 0.0332 0.0546
Echinococcus granulosus survival motor neuron protein 1 0.0156 0.0608 0.0604
Giardia lamblia Cathepsin L precursor 0.0171 0.0674 0.1709
Mycobacterium tuberculosis Probable oxidoreductase 0.0265 0.1083 0.1795
Brugia malayi Cathepsin L-like precursor 0.0688 0.2929 0.349
Schistosoma mansoni bromodomain containing protein 0.006 0.0189 0.0185
Loa Loa (eye worm) hypothetical protein 0.0073 0.0244 0.0286
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 0.0023 0.0024 0.0033
Schistosoma mansoni aldehyde dehydrogenase 0.0023 0.0024 0.0021
Brugia malayi Cathepsin L-like precursor 0.0688 0.2929 0.349
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0098 0.0112
Brugia malayi Pre-SET motif family protein 0.0103 0.0376 0.0444
Giardia lamblia Cathepsin B precursor 0.0717 0.3058 0.7981
Schistosoma mansoni rab6-interacting 0.0023 0.0024 0.0021
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0118 0.0441 0.1152
Schistosoma mansoni cathepsin F (C01 family) 0.0478 0.2015 0.2012
Entamoeba histolytica cysteine protease, putative 0.0381 0.1588 0.4114
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0171 0.0674 0.1761
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0027 0.0043 0.0127
Echinococcus multilocularis thioredoxin glutathione reductase 0.0105 0.0383 0.038
Leishmania major trypanothione reductase 0.0105 0.0382 0.1237
Trichomonas vaginalis glucosylceramidase, putative 0.015 0.0579 0.1512
Brugia malayi PHD-finger family protein 0.0026 0.0041 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0118 0.0441 0.1152
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0086 0.03 0.0296
Mycobacterium tuberculosis Conserved protein 0.0093 0.0332 0.0546
Trichomonas vaginalis penicillin-binding protein, putative 0.0093 0.0332 0.0868
Schistosoma mansoni lipoxygenase 0.0136 0.0519 0.0516
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0036 0.0083 0.008
Schistosoma mansoni ran 0.0027 0.0043 0.0039
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0036 0.0083 0.0259
Brugia malayi cathepsin F-like cysteine proteinase 0.0209 0.0839 0.0997
Toxoplasma gondii aldehyde dehydrogenase 0.0412 0.1725 0.5634
Echinococcus multilocularis importin subunit beta 1 0.0037 0.0085 0.0082
Brugia malayi hypothetical protein 0.004 0.01 0.0114
Onchocerca volvulus 0.0688 0.2929 0.8473
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0339 0.0335
Echinococcus multilocularis Polycystic kidney disease protein 0.0023 0.0024 0.0021
Loa Loa (eye worm) hypothetical protein 0.0209 0.0839 0.0997
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0083 0.0259
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0115 0.0427 0.1115
Brugia malayi MAP kinase sur-1 0.0033 0.0071 0.008
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.004 0.01 0.0114
Schistosoma mansoni hypothetical protein 0.1127 0.4848 0.4846
Echinococcus multilocularis cathepsin L cysteine protease 0.0688 0.2929 0.2927
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0171 0.0674 0.229
Trypanosoma cruzi metacaspase 5, putative 0.0115 0.0427 0.0504
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0688 0.2929 0.7655
Echinococcus multilocularis caspase 3 0.0147 0.0569 0.0566
Mycobacterium tuberculosis Probable dehydrogenase 0.0239 0.0967 0.1601
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0036 0.0083 0.0095
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0688 0.2929 0.9576
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0381 0.1588 0.4151
Entamoeba histolytica cysteine protease, putative 0.0688 0.2929 0.764
Echinococcus multilocularis cathepsin b 0.1937 0.8384 0.8383
Plasmodium falciparum importin beta, putative 0.0037 0.0085 0.0277
Echinococcus multilocularis expressed conserved protein 0.0077 0.0261 0.0257
Echinococcus granulosus lysosomal alpha glucosidase 0.0354 0.1473 0.147
Echinococcus multilocularis RUN 0.0023 0.0024 0.0021
Schistosoma mansoni hypothetical protein 0.0034 0.0073 0.0069
Brugia malayi Cathepsin L-like precursor 0.0688 0.2929 0.349
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0171 0.0674 0.1761
Echinococcus multilocularis transcription factor Dp 1 0.005 0.0142 0.0138
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0118 0.0441 0.143
Echinococcus multilocularis mitogen activated protein kinase 0.0033 0.0071 0.0068
Brugia malayi TAR-binding protein 0.0042 0.0108 0.0124
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0036 0.0095
Echinococcus granulosus dnaJ subfamily B 0.1127 0.4848 0.4846
Plasmodium vivax importin-beta 2, putative 0.0037 0.0085 0.0277
Brugia malayi hypothetical protein 0.0319 0.1318 0.1567
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0478 0.2015 0.2399
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0098 0.0156
Loa Loa (eye worm) TAR-binding protein 0.0042 0.0108 0.0124
Brugia malayi MH2 domain containing protein 0.0103 0.0374 0.0442
Trypanosoma cruzi cysteine peptidase, putative 0.0688 0.2929 0.349
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0381 0.1588 0.4151
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0688 0.2929 0.7655
Leishmania major aldehyde dehydrogenase, putative 0.0023 0.0024 0.0065
Schistosoma mansoni alpha glucosidase 0.0079 0.0269 0.0265
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0118 0.0441 0.0438
Entamoeba histolytica Ran family GTPase 0.0027 0.0043 0.0049
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0688 0.2929 0.9576
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0171 0.0674 0.229
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0093 0.0332 0.0546
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0093 0.0332 0.1706
Trypanosoma cruzi PAB1-binding protein , putative 0.004 0.01 0.0114
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0115 0.0427 0.1115
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0098 0.0307
Plasmodium falciparum glutathione reductase 0.0105 0.0382 0.1291
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0688 0.2929 0.9576
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0478 0.2015 0.5266
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0032 0.0064 0.006
Brugia malayi cathepsin F-like cysteine proteinase 0.0171 0.0674 0.0799
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0688 0.2929 0.7655
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0115 0.0427 0.1383
Echinococcus granulosus cathepsin b 0.1937 0.8384 0.8383
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0265 0.1083 0.5112
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0171 0.0674 0.1709
Brugia malayi glutathione reductase 0.0105 0.0382 0.0451
Trichomonas vaginalis CMGC family protein kinase 0.0033 0.0071 0.0186
Trichomonas vaginalis CMGC family protein kinase 0.0033 0.0071 0.0186
Trichomonas vaginalis glutaminase, putative 0.0359 0.1492 0.3899
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0688 0.2929 0.349
Echinococcus granulosus cathepsin L cysteine protease 0.0381 0.1588 0.1585
Schistosoma mansoni gabp alpha 0.007 0.023 0.0227
Echinococcus granulosus Polycystic kidney disease protein 0.0023 0.0024 0.0021
Giardia lamblia Cathepsin L precursor 0.0171 0.0674 0.1709
Echinococcus multilocularis aldehyde dehydrogenase family 3 member B1 0.0023 0.0024 0.0021
Giardia lamblia Cathepsin L precursor 0.0171 0.0674 0.1709
Entamoeba histolytica cysteine protease, putative 0.0171 0.0674 0.1709
Echinococcus multilocularis betaine aldehyde dehydrogenase 0.0023 0.0024 0.0021
Plasmodium vivax hypothetical protein, conserved 0.0115 0.0427 0.1445
Brugia malayi Ets-domain containing protein 0.007 0.023 0.027
Schistosoma mansoni hypothetical protein 0.0023 0.0024 0.0021
Trichomonas vaginalis glucosylceramidase, putative 0.015 0.0579 0.1512
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0027 0.0043 0.0049
Plasmodium falciparum serine repeat antigen 5 0.0171 0.0674 0.229
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0688 0.2929 0.9576
Onchocerca volvulus 0.0032 0.0064 0.0148
Schistosoma mansoni ran 0.0027 0.0043 0.0039
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0688 0.2929 0.2927
Entamoeba histolytica cysteine protease, putative 0.0381 0.1588 0.4114
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0036 0.0095
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0079 0.0269 0.0866
Leishmania major GTP-binding protein, putative 0.0027 0.0043 0.0127
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.0053 0.0139
Trichomonas vaginalis set domain proteins, putative 0.0808 0.3454 0.9028
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0171 0.0674 0.1761
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0011
Schistosoma mansoni aldehyde dehydrogenase 0.0023 0.0024 0.0021
Schistosoma mansoni aryl hydrocarbon receptor 0.0035 0.0078 0.0075
Brugia malayi F/Y-rich N-terminus family protein 0.003 0.0054 0.006
Entamoeba histolytica cysteine protease, putative 0.0381 0.1588 0.4114
Onchocerca volvulus 0.0688 0.2929 0.8473
Trichomonas vaginalis conserved hypothetical protein 0.0171 0.0674 0.1761
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0057 0.0175 0.0171
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0029 0.0053 0.0139
Leishmania major cathepsin L-like protease 0.0688 0.2929 0.9576
Plasmodium vivax vivapain-1 0.0381 0.1588 0.5416
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0171 0.0674 0.229
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0033 0.0071 0.0219
Brugia malayi Papain family cysteine protease containing protein 0.0171 0.0674 0.0799
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0082 0.0282 0.0679
Onchocerca volvulus 0.0079 0.0271 0.0748
Echinococcus granulosus cathepsin l cysteine peptidase 0.0688 0.2929 0.2927
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0083 0.0259
Echinococcus granulosus cathepsin l1 0.0688 0.2929 0.2927
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0027 0.0043 0.0046
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0086 0.03 0.0296
Brugia malayi hypothetical protein 0.0026 0.0038 0.004
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0098 0.0409
Brugia malayi cathepsin L-like cysteine proteinase 0.0171 0.0674 0.0799
Echinococcus granulosus caspase 3 0.0147 0.0569 0.0566
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0412 0.1725 0.1722
Trichomonas vaginalis Importin beta-1 subunit, putative 0.003 0.0055 0.0143
Schistosoma mansoni hypothetical protein 0.0073 0.0244 0.024
Entamoeba histolytica cysteine protease, putative 0.0381 0.1588 0.4114
Trypanosoma brucei protein kinase, putative 0.0033 0.0071 0.0219
Echinococcus multilocularis GPCR, family 2 0.0073 0.0244 0.024
Brugia malayi Heterochromatin protein 1 0.0046 0.0126 0.0146
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1937 0.8384 0.8383
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0095 0.0339 0.0399
Brugia malayi RNA, U transporter 1 0.0104 0.038 0.0449
Brugia malayi hypothetical protein 0.0156 0.0608 0.072
Treponema pallidum fructose-bisphosphate aldolase 0.0893 0.3826 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0136 0.0519 0.0516
Loa Loa (eye worm) fli-1 protein 0.0212 0.0851 0.1011
Echinococcus granulosus neutral alpha glucosidase AB 0.0079 0.0269 0.0265
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0717 0.3058 0.3056
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0688 0.2929 0.7655
Brugia malayi Papain family cysteine protease containing protein 0.0381 0.1588 0.189
Trypanosoma cruzi hypothetical protein, conserved 0.0093 0.0332 0.0392
Echinococcus granulosus zinc finger protein 0.0022 0.002 0.0017
Loa Loa (eye worm) delta-1-pyrroline-5-carboxylate dehydrogenase 0.0023 0.0024 0.0024
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0688 0.2929 0.9576
Trichomonas vaginalis succinate semialdehyde dehydrogenase, putative 0.0023 0.0024 0.0063
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0893 0.3826 1
Giardia lamblia Hypothetical protein 0.0171 0.0674 0.1709
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0239 0.0967 0.1601
Loa Loa (eye worm) hypothetical protein 0.0478 0.2015 0.2399
Echinococcus multilocularis apoptotic protease activating factor 1 0.0142 0.0546 0.0542
Giardia lamblia Cathepsin B precursor 0.0171 0.0674 0.1709
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0036 0.0095
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0478 0.2015 0.5266
Trichomonas vaginalis helicase, putative 0.0018 0.0003 0.0009
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0023 0.0027 0.0024
Loa Loa (eye worm) hypothetical protein 0.0209 0.0839 0.0997
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0381 0.1588 0.1585
Plasmodium falciparum metacaspase 1 0.0115 0.0427 0.1445
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0098 0.0095
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0269 0.0316
Toxoplasma gondii LsmAD domain-containing protein 0.004 0.01 0.0314
Trypanosoma cruzi metacaspase, putative 0.0115 0.0427 0.0504
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.015 0.0579 0.0686
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.015 0.0579 0.0686
Trichomonas vaginalis glucosylceramidase, putative 0.0098 0.0354 0.0925
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0688 0.2929 0.7655
Schistosoma mansoni lozenge 0.004 0.01 0.0096
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0036 0.0083 0.0328
Mycobacterium tuberculosis Probable methylmalonate-semialdehyde dehydrogenase MmsA (methylmalonic acid semialdehyde dehydrogenase) (MMSDH) 0.0023 0.0024 0.0033
Brugia malayi hypothetical protein 0.0023 0.0024 0.0024
Entamoeba histolytica hypothetical protein 0.0171 0.0674 0.1709
Brugia malayi Glycosyl hydrolases family 31 protein 0.0079 0.0269 0.0316
Loa Loa (eye worm) CXXC zinc finger family protein 0.0079 0.0271 0.0318
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0083 0.0095
Schistosoma mansoni zinc finger protein 0.0022 0.002 0.0017
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0171 0.0674 0.229
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0118 0.0441 0.1152
Brugia malayi Cathepsin L-like precursor 0.0209 0.0839 0.0997
Trichomonas vaginalis glucosylceramidase, putative 0.0103 0.0377 0.0985
Plasmodium falciparum serine repeat antigen 9 0.0171 0.0674 0.229
Schistosoma mansoni hypothetical protein 0.0034 0.0073 0.0069
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0086 0.03 0.0353
Loa Loa (eye worm) histone methyltransferase 0.0028 0.0048 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0003 0.0009
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0027 0.0043 0.0046
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0098 0.0321
Brugia malayi hypoxia-induced factor 1 0.0108 0.0398 0.0471
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0171 0.0674 0.229
Trichomonas vaginalis CMGC family protein kinase 0.0033 0.0071 0.0186
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0171 0.0674 0.1761
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0098 0.0256
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0003 0.0009
Wolbachia endosymbiont of Brugia malayi recombinase A 0.0085 0.0295 1
Brugia malayi cathepsin B-like cysteine proteinase 0.1937 0.8384 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0082 0.0282 0.0279
Giardia lamblia Cathepsin L precursor 0.0171 0.0674 0.1709
Schistosoma mansoni ap endonuclease 0.004 0.0098 0.0095
Mycobacterium tuberculosis Conserved protein 0.0093 0.0332 0.0546
Brugia malayi hypothetical protein 0.0229 0.0925 0.1099
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0079 0.0269 0.0702
Loa Loa (eye worm) glutaminase 0.0359 0.1492 0.1775
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0027 0.0043 0.0127
Trichomonas vaginalis conserved hypothetical protein 0.0115 0.0427 0.1115
Schistosoma mansoni transcription factor LCR-F1 0.0138 0.0529 0.0526
Loa Loa (eye worm) hypothetical protein 0.0093 0.0332 0.0392
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0027 0.0043 0.0039
Echinococcus multilocularis neutral alpha glucosidase AB 0.0079 0.0269 0.0265
Schistosoma mansoni aldehyde dehydrogenase 0.0023 0.0024 0.0021
Echinococcus granulosus RUN 0.0023 0.0024 0.0021
Giardia lamblia Cathepsin L precursor 0.0171 0.0674 0.1709
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0003 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0115 0.0427 0.1115
Echinococcus multilocularis cathepsin L 0.0381 0.1588 0.1585
Trichomonas vaginalis glucosylceramidase, putative 0.0098 0.0354 0.0925
Brugia malayi Doublecortin family protein 0.0023 0.0024 0.0024
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0036 0.0083 0.0328
Echinococcus multilocularis cathepsin L cysteine protease 0.0688 0.2929 0.2927
Loa Loa (eye worm) hypothetical protein 0.0118 0.0442 0.0523
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0042 0.0108 0.0124
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0086 0.03 0.0968
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0688 0.2929 0.7655
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0036 0.0083 0.0271
Giardia lamblia Cathepsin B precursor 0.0717 0.3058 0.7981
Plasmodium vivax unspecified product 0.0381 0.1588 0.5416
Trichomonas vaginalis alpha-glucosidase, putative 0.0079 0.0269 0.0702
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0688 0.2929 0.2927
Schistosoma mansoni aldehyde dehydrogenase 0.0023 0.0024 0.0021
Schistosoma mansoni single-minded 0.0035 0.0078 0.0075
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1006 0.4318 0.4316
Schistosoma mansoni hypothetical protein 0.0073 0.0244 0.024
Trypanosoma cruzi hypothetical protein, conserved 0.0093 0.0332 0.0392
Schistosoma mansoni patched 1 0.0035 0.0078 0.0075
Trypanosoma brucei metacaspase 0.0115 0.0427 0.1383
Schistosoma mansoni cathepsin B (C01 family) 0.0171 0.0674 0.0671
Loa Loa (eye worm) hypothetical protein 0.0034 0.0073 0.0082
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0036 0.0095
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0079 0.0269 0.0316
Trichomonas vaginalis glucosylceramidase, putative 0.015 0.0579 0.1512
Schistosoma mansoni hypothetical protein 0.0391 0.1633 0.163
Trichomonas vaginalis glucosylceramidase, putative 0.0098 0.0354 0.0925
Schistosoma mansoni alpha-glucosidase 0.0305 0.1257 0.1254
Trichomonas vaginalis conserved hypothetical protein 0.0115 0.0427 0.1115
Echinococcus multilocularis muscleblind protein 1 0.02 0.08 0.0797
Echinococcus multilocularis microtubule associated protein 2 0.2307 1 1
Loa Loa (eye worm) hypothetical protein 0.0093 0.0332 0.0392
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0023 0.0024 0.0021
Schistosoma mansoni cathepsin S (C01 family) 0.0171 0.0674 0.0671
Schistosoma mansoni hypothetical protein 0.0032 0.0064 0.0061
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0029 0.0053 0.0139
Echinococcus granulosus cathepsin l1 0.0478 0.2015 0.2012
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0079 0.0269 0.0643
Trypanosoma brucei metacaspase MCA2 0.0115 0.0427 0.1383
Schistosoma mansoni caspase-7 (C14 family) 0.0257 0.1047 0.1044
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0073 0.0244 0.024
Echinococcus granulosus transcription factor Dp 1 0.005 0.0142 0.0138
Trypanosoma cruzi metacaspase, putative 0.0115 0.0427 0.0504
Brugia malayi Fli-1 protein 0.0212 0.0851 0.1011
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0003 0.0009
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0098 0.0095
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0339 0.0335
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0032 0.0028
Toxoplasma gondii preprocathepsin c precursor, putative 0.0171 0.0674 0.2193
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0098 0.0112
Plasmodium falciparum cysteine proteinase falcipain 1 0.0381 0.1588 0.5416
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0893 0.3826 1
Onchocerca volvulus 0.0205 0.082 0.2345
Brugia malayi chromobox protein homolog 3 0.0026 0.0038 0.004
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0033 0.0071 0.0219
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0033 0.0071 0.008
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0032 0.0028
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0688 0.2929 0.7655
Schistosoma mansoni hypothetical protein 0.0142 0.0546 0.0542
Entamoeba histolytica cysteine proteinase, putative 0.0381 0.1588 0.4114
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0688 0.2929 0.7655
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0023 0.0024 0.0024
Schistosoma mansoni cathepsin s 0.0209 0.0839 0.0836
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0036 0.0083 0.008
Loa Loa (eye worm) hypothetical protein 0.0023 0.0024 0.0024
Mycobacterium tuberculosis Probable hydrolase 0.0093 0.0332 0.0546
Schistosoma mansoni polycystin 1-related 0.0023 0.0024 0.0021
Echinococcus multilocularis neuropeptide receptor A26 0.0316 0.1307 0.1303
Onchocerca volvulus Cell death protein 3 homolog 0.0257 0.1047 0.3005
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0171 0.0674 0.1709
Brugia malayi Bromodomain containing protein 0.0071 0.0234 0.0274
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0023 0.0024 0.0065
Trypanosoma brucei glycosyl hydrolase-like protein 0.0029 0.0053 0.016
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0688 0.2929 0.9576
Giardia lamblia Cathepsin L-like protease 0.0171 0.0674 0.1709
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0118 0.0441 0.143
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0171 0.0674 0.1761
Loa Loa (eye worm) heterochromatin protein 1 0.0046 0.0126 0.0146
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0265 0.1083 0.1795
Plasmodium vivax serine-repeat antigen (SERA) 0.0171 0.0674 0.229
Entamoeba histolytica cysteine proteinase, putative 0.0478 0.2015 0.5236
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0098 0.0112
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1937 0.8384 0.8383
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0171 0.0674 0.229
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0083 0.0288 0.0284
Echinococcus multilocularis beta LACTamase domain containing family member 0.0093 0.0332 0.0329
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0171 0.0674 0.1761
Leishmania major cysteine peptidase A (CPA) 0.0688 0.2929 0.9576
Plasmodium falciparum serine repeat antigen 8 0.0171 0.0674 0.229
Brugia malayi Cathepsin L-like precursor 0.0478 0.2015 0.2399
Mycobacterium tuberculosis Probable lipase LipD 0.0093 0.0332 0.0546
Mycobacterium ulcerans recombinase A 0.0085 0.0295 0.1501
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0688 0.2929 0.349
Loa Loa (eye worm) cytochrome P450 family protein 0.0035 0.0076 0.0086
Plasmodium falciparum serine repeat antigen 6 0.0171 0.0674 0.229
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1937 0.8384 0.8383
Loa Loa (eye worm) hypothetical protein 0.0319 0.1318 0.1567
Onchocerca volvulus Cathepsin L homolog 0.0688 0.2929 0.8473
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0036 0.0083 0.2186
Trypanosoma cruzi DNA repair protein, putative 0.0026 0.0039 0.0042
Trypanosoma cruzi major cysteine proteinase, putative 0.0171 0.0674 0.0799
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0171 0.0674 0.229
Plasmodium vivax hypothetical protein, conserved 0.0093 0.0332 0.1122
Trypanosoma brucei PAB1-binding protein , putative 0.004 0.01 0.0314
Trichomonas vaginalis ran, putative 0.0027 0.0043 0.0112
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0098 0.0256
Echinococcus granulosus thioredoxin glutathione reductase 0.0105 0.0383 0.038
Brugia malayi RNA binding protein 0.0042 0.0108 0.0124
Trypanosoma cruzi cysteine proteinase, putative 0.0381 0.1588 0.189
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0381 0.1588 0.1585
Mycobacterium ulcerans aldehyde dehydrogenase 0.0412 0.1725 0.9415
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0171 0.0674 0.0671
Mycobacterium tuberculosis Probable esterase LipL 0.0093 0.0332 0.0546
Brugia malayi cathepsin L precursor 0.0171 0.0674 0.0799
Trichomonas vaginalis alpha-glucosidase, putative 0.0079 0.0269 0.0702
Loa Loa (eye worm) hypothetical protein 0.0093 0.0332 0.0392
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0036 0.0083 0.2186
Echinococcus granulosus cysteine protease 0.0381 0.1588 0.1585
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0436 0.1831 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0023 0.0024 0.0033
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0171 0.0674 0.229
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0239 0.0967 0.4551
Brugia malayi beta-lactamase family protein 0.0093 0.0332 0.0392
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0098 0.0353 0.0349
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0005 0.0013
Echinococcus granulosus chromobox protein 1 0.0046 0.0126 0.0123
Echinococcus granulosus GA binding protein alpha chain 0.007 0.023 0.0227
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.0098 0.2725
Echinococcus multilocularis GA binding protein alpha chain 0.007 0.023 0.0227
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0004 0.0001
Trichomonas vaginalis D-aminoacylase, putative 0.0093 0.0332 0.0868
Brugia malayi beta-lactamase family protein 0.0093 0.0332 0.0392
Giardia lamblia Cathepsin B precursor 0.0171 0.0674 0.1709
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0209 0.0839 0.0997
Entamoeba histolytica cysteine protease, putative 0.0171 0.0674 0.1709
Brugia malayi beta-lactamase 0.0093 0.0332 0.0392
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0171 0.0674 0.1761
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0023 0.0024 0.0065
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0036 0.0083 0.0132
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0265 0.1083 0.1795
Echinococcus granulosus Fatty aldehyde dehydrogenase 0.0023 0.0024 0.0021
Treponema pallidum recombinase A 0.0085 0.0295 0.0713
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0118 0.0441 0.0521
Trypanosoma cruzi metacaspase, putative 0.0115 0.0427 0.0504
Brugia malayi fibroinase precursor 0.0171 0.0674 0.0799
Schistosoma mansoni ets-related 0.0212 0.0851 0.0848
Echinococcus granulosus caspase 8 0.0115 0.0427 0.0423
Plasmodium falciparum serine repeat antigen 7 0.0171 0.0674 0.229
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0138 0.0529 0.0526
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0027 0.0043 0.0132
Loa Loa (eye worm) hypothetical protein 0.006 0.0186 0.0217
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0688 0.2929 0.7655
Plasmodium falciparum ataxin-2 like protein, putative 0.004 0.01 0.0328
Entamoeba histolytica cysteine protease, putative 0.0171 0.0674 0.1709
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0036 0.0083 0.0271
Entamoeba histolytica cysteine protease, putative 0.0171 0.0674 0.1709
Plasmodium vivax SET domain protein, putative 0.0103 0.0376 0.1273
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0086 0.03 0.0968
Plasmodium vivax unspecified product 0.0209 0.0839 0.2856
Loa Loa (eye worm) hypothetical protein 0.0142 0.0546 0.0646
Loa Loa (eye worm) PHD-finger family protein 0.0018 0.0005 0.0001
Schistosoma mansoni cpg binding protein 0.0079 0.0271 0.0267
Loa Loa (eye worm) hypothetical protein 0.0036 0.0082 0.0093
Plasmodium vivax multidomain scavenger receptor, putative 0.0023 0.0024 0.0069
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0893 0.3826 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.071 0.3027 0.3607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0688 0.2929 0.7655
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0093 0.0332 0.0546
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0086 0.03 0.0353
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0098 0.0307
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0033 0.0071 0.008
Loa Loa (eye worm) hypothetical protein 0.1937 0.8384 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0027 0.0043 0.0046
Onchocerca volvulus 0.0229 0.0925 0.265
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0381 0.1588 0.5186
Plasmodium vivax serine-repeat antigen (SERA) 0.0171 0.0674 0.229
Giardia lamblia Fructose-bisphosphate aldolase 0.0893 0.3826 1
Mycobacterium tuberculosis Probable gamma-glutamyl phosphate reductase protein ProA (GPR) (glutamate-5-semialdehyde dehydrogenase) (glutamyl-gamma-semialde 0.0023 0.0024 0.0033
Mycobacterium leprae Conserved hypothetical protein 0.0497 0.2096 1
Giardia lamblia Cathepsin L-like protease 0.0171 0.0674 0.1709
Toxoplasma gondii thioredoxin reductase 0.0105 0.0382 0.1237
Schistosoma mansoni tar DNA-binding protein 0.0042 0.0108 0.0104
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0171 0.0674 0.1761
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0093 0.0332 0.0546
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0073 0.0244 0.024
Leishmania major cathepsin L-like protease 0.0688 0.2929 0.9576
Loa Loa (eye worm) transcription factor SMAD2 0.0103 0.0374 0.0442
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0093 0.0332 0.0392
Giardia lamblia Hypothetical protein 0.0171 0.0674 0.1709
Onchocerca volvulus 0.0023 0.0024 0.0032
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0412 0.1725 0.1722
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0171 0.0674 0.229
Toxoplasma gondii exonuclease III APE 0.004 0.0098 0.0307
Brugia malayi Papain family cysteine protease containing protein 0.0381 0.1588 0.189
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.0053 0.0139
Trypanosoma brucei trypanothione reductase 0.0105 0.0382 0.1237
Brugia malayi cathepsin Z-like cysteine proteinase 0.0171 0.0674 0.0799
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0118 0.0441 0.0438
Echinococcus multilocularis lysosomal alpha glucosidase 0.0354 0.1473 0.147
Trichomonas vaginalis chromobox protein, putative 0.0046 0.0126 0.033
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0095 0.0339 0.0399
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0083 0.0095
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0023 0.0024 0.0024
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0688 0.2929 0.7655
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0057 0.0175 0.0171
Echinococcus multilocularis cpg binding protein 0.0085 0.0298 0.0294
Trypanosoma cruzi importin beta-1 subunit, putative 0.003 0.0055 0.006
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0118 0.0441 0.0438
Echinococcus granulosus caspase 2 0.0257 0.1047 0.1044
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0172 0.0675 0.0671
Schistosoma mansoni aldehyde dehydrogenase 0.0023 0.0024 0.0021
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0171 0.0674 0.0799
Loa Loa (eye worm) doublecortin family protein 0.0023 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0037 0.0085 0.0097
Plasmodium falciparum cysteine proteinase falcipain 3 0.0688 0.2929 1
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0209 0.0839 0.0997
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0073 0.0244 0.0286
Plasmodium vivax ataxin-2 like protein, putative 0.004 0.01 0.0328
Echinococcus multilocularis caspase 0.0262 0.1071 0.1067
Onchocerca volvulus 0.0171 0.0674 0.1919
Schistosoma mansoni tar DNA-binding protein 0.0042 0.0108 0.0104
Entamoeba histolytica cysteine protease, putative 0.0381 0.1588 0.4114
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0036 0.0083 0.0259
Onchocerca volvulus 0.0093 0.0332 0.0927
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0083 0.0259
Trypanosoma brucei cysteine peptidase C (CPC) 0.0717 0.3058 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0093 0.0332 0.0868
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0004 0.0001
Echinococcus multilocularis tar DNA binding protein 0.0042 0.0108 0.0104
Entamoeba histolytica cysteine protease, putative 0.0171 0.0674 0.1709
Toxoplasma gondii histone lysine methyltransferase SET1 0.0156 0.0605 0.1969
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0027 0.0041 0.0044
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0171 0.0674 0.0671
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0339 0.0335
Schistosoma mansoni cpg binding protein 0.0085 0.0298 0.0294
Trichomonas vaginalis glucosylceramidase, putative 0.015 0.0579 0.1512
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0171 0.0674 0.0671
Leishmania major metacaspase, putative 0.0115 0.0427 0.1383
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0171 0.0674 0.0671
Schistosoma mansoni loxhd1 0.0023 0.0024 0.0021
Leishmania major aldehyde dehydrogenase, putative 0.0023 0.0024 0.0065
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0027 0.0043 0.0132
Onchocerca volvulus Aldehyde dehydrogenase homolog 0.0023 0.0024 0.0031
Leishmania major aldehyde dehydrogenase, putative 0.0023 0.0024 0.0065
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0024 0.0021
Trypanosoma cruzi cysteine protease, putative 0.0381 0.1588 0.189
Brugia malayi Muscleblind-like protein 0.02 0.08 0.095
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0171 0.0674 0.1761
Entamoeba histolytica cysteine proteinase, putative 0.0381 0.1588 0.4114
Schistosoma mansoni tar DNA-binding protein 0.0042 0.0108 0.0104
Trichomonas vaginalis sucrase-isomaltase, putative 0.0079 0.0269 0.0702
Mycobacterium tuberculosis Possible succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD2 0.0023 0.0024 0.0033
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0105 0.0382 0.0628
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0003 0.0009
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0023 0.0024 0.0065
Echinococcus granulosus caspase 0.0262 0.1071 0.1067
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0004 0.0001
Echinococcus granulosus betaine aldehyde dehydrogenase 0.0023 0.0024 0.0021
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0118 0.0442 0.0439
Brugia malayi Papain family cysteine protease containing protein 0.0171 0.0674 0.0799
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0023 0.0024 0.0024
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0893 0.3826 1
Schistosoma mansoni survival motor neuron protein 0.0032 0.0064 0.0061
Trypanosoma cruzi cysteine peptidase, putative 0.0381 0.1588 0.189
Echinococcus granulosus sterol regulatory element binding protein 0.0035 0.0078 0.0075
Giardia lamblia Cathepsin L precursor 0.0171 0.0674 0.1709
Schistosoma mansoni glutaminase 0.0359 0.1492 0.1489
Echinococcus multilocularis protein dispatched 1 0.004 0.01 0.0097
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0023 0.0024 0.0024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0688 0.2929 0.7655
Echinococcus granulosus neuropeptide s receptor 0.0316 0.1307 0.1303
Onchocerca volvulus 0.0023 0.0024 0.0032
Schistosoma mansoni delta 1-pyrroline-5-carboxylate synthetase 0.0023 0.0024 0.0021
Leishmania major delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0023 0.0024 0.0065
Echinococcus granulosus tar DNA binding protein 0.0042 0.0108 0.0104
Trypanosoma cruzi cysteine peptidase, putative 0.0209 0.0839 0.0997
Entamoeba histolytica cysteine protease, putative 0.0381 0.1588 0.4114
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0003 0.0009
Entamoeba histolytica cysteine proteinase, putative 0.0688 0.2929 0.764
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0004 0.0001
Entamoeba histolytica cysteine protease, putative 0.0381 0.1588 0.4114
Brugia malayi Aldehyde dehydrogenase protein 4 0.0023 0.0024 0.0024
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0688 0.2929 0.9576
Loa Loa (eye worm) beta-lactamase 0.0093 0.0332 0.0392
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0028 0.0046 0.0096
Schistosoma mansoni hypothetical protein 0.0158 0.0614 0.0611
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0023 0.0024 0.0021
Mycobacterium ulcerans lipase LipD 0.0093 0.0332 0.1706
Mycobacterium ulcerans putative regulatory protein 0.0026 0.0038 0.0078
Toxoplasma gondii cathepsin CPL 0.0688 0.2929 0.9576
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0688 0.2929 0.9576
Entamoeba histolytica cysteine protease, putative 0.0381 0.1588 0.4114
Brugia malayi cathepsin Z-like cysteine proteinase 0.0171 0.0674 0.0799
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0029 0.0053 0.0058
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0035 0.0078 0.0089
Plasmodium falciparum glutathione reductase 0.0036 0.0083 0.0271
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0003 0.0009
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0381 0.1588 0.189
Trichomonas vaginalis alpha-glucosidase, putative 0.0079 0.0269 0.0702
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0071 0.0068
Echinococcus multilocularis mitogen activated protein kinase 3 0.0033 0.0071 0.0068
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0171 0.0674 0.1761
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0029 0.0053 0.0058
Treponema pallidum NADH oxidase 0.0036 0.0083 0.0156
Mycobacterium leprae Probable lipase LipE 0.0093 0.0332 0.1487
Brugia malayi Cathepsin L-like precursor 0.0688 0.2929 0.349
Schistosoma mansoni cathepsin F (C01 family) 0.0688 0.2929 0.2927
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0115 0.0427 0.0423
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0003 0.0009
Plasmodium falciparum metacaspase-like protein 0.0115 0.0427 0.1445
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0171 0.0674 0.1761
Brugia malayi Cathepsin L-like precursor 0.0478 0.2015 0.2399
Echinococcus multilocularis X box binding protein 1 0.0165 0.0644 0.064
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0436 0.1831 0.8719
Entamoeba histolytica hypothetical protein 0.003 0.0055 0.0081
Trypanosoma cruzi DNA repair protein, putative 0.0026 0.0039 0.0042
Entamoeba histolytica cysteine protease, putative 0.0381 0.1588 0.4114
Trichomonas vaginalis chromobox protein, putative 0.0028 0.0046 0.0121
Trichomonas vaginalis conserved hypothetical protein 0.0115 0.0427 0.1115
Leishmania major cathepsin L-like protease 0.0688 0.2929 0.9576
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0115 0.0427 0.1115
Echinococcus granulosus cathepsin b 0.1937 0.8384 0.8383
Brugia malayi hypothetical protein 0.0142 0.0546 0.0646
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0171 0.0674 0.0799
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0717 0.3058 1
Echinococcus granulosus muscleblind protein 0.02 0.08 0.0797
Toxoplasma gondii gamma-glutamyl phosphate reductase, putative 0.0023 0.0024 0.0065
Entamoeba histolytica cysteine protease, putative 0.0381 0.1588 0.4114
Plasmodium vivax vivapain-2 0.0688 0.2929 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0688 0.2929 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0412 0.1725 0.9415
Leishmania major cathepsin L-like protease 0.0688 0.2929 0.9576
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0688 0.2929 0.7655
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0111 0.0409 0.0406
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.0098 0.0194
Plasmodium vivax vivapain-2 0.0688 0.2929 1
Echinococcus granulosus Niemann Pick C1 protein 0.0082 0.0282 0.0279
Plasmodium falciparum serine repeat antigen 3 0.0171 0.0674 0.229
Schistosoma mansoni alpha-glucosidase 0.0305 0.1257 0.1254
Trypanosoma cruzi cysteine peptidase, putative 0.0688 0.2929 0.349
Echinococcus granulosus cpg binding protein 0.0085 0.0298 0.0294
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0171 0.0674 0.229
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0098 0.0194
Mycobacterium ulcerans beta-lactamase 0.0093 0.0332 0.1706
Echinococcus granulosus GPCR family 2 0.0073 0.0244 0.024
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0115 0.0427 0.1115
Onchocerca volvulus 0.0688 0.2929 0.8473
Entamoeba histolytica cysteine proteinase 1, putative 0.0381 0.1588 0.4114
Plasmodium falciparum LCCL domain-containing protein 0.0023 0.0024 0.0069
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0381 0.1588 0.1585
Echinococcus multilocularis survival motor neuron protein 1 0.0156 0.0608 0.0604
Trypanosoma cruzi major cysteine proteinase, putative 0.0171 0.0674 0.0799
Brugia malayi CXXC zinc finger family protein 0.0079 0.0271 0.0318
Brugia malayi Niemann-Pick C1 protein precursor 0.0082 0.0282 0.0332
Trichomonas vaginalis glucosylceramidase, putative 0.0098 0.0354 0.0925
Schistosoma mansoni aldehyde dehydrogenase 0.0412 0.1725 0.1722
Schistosoma mansoni hypothetical protein 0.0023 0.0024 0.0021
Brugia malayi Cathepsin L-like precursor 0.0688 0.2929 0.349
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0036 0.0083 0.0259
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0339 0.0335
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0339 0.0335
Plasmodium vivax unspecified product 0.0171 0.0674 0.229
Echinococcus multilocularis transfer RNA-Lys 0.0026 0.0038 0.0035
Entamoeba histolytica hypothetical protein 0.0138 0.0529 0.1328
Echinococcus multilocularis Fatty aldehyde dehydrogenase 0.0023 0.0024 0.0021
Entamoeba histolytica hypothetical protein 0.0138 0.0529 0.1328
Echinococcus granulosus mixed lineage leukemia protein mll 0.0023 0.0027 0.0024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0688 0.2929 0.7655
Schistosoma mansoni succinate semialdehyde dehydrogenase 0.0023 0.0024 0.0021
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0262 0.1071 0.1067
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0115 0.0427 0.1115
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0893 0.3826 1
Loa Loa (eye worm) hypothetical protein 0.0319 0.1318 0.1567
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0391 0.1633 0.1944
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0086 0.03 0.0725
Brugia malayi Succinate semialdehyde dehydrogenase, mitochondrial precursor 0.0023 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0093 0.0332 0.0392
Trypanosoma brucei importin beta-1 subunit, putative 0.0037 0.0085 0.0265
Mycobacterium tuberculosis Probable aldehyde dehydrogenase (NAD+) dependent 0.0023 0.0024 0.0033
Loa Loa (eye worm) hypothetical protein 0.0023 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0209 0.0839 0.0997
Onchocerca volvulus Cathepsin L homolog 0.0688 0.2929 0.8473
Loa Loa (eye worm) thioredoxin reductase 0.0105 0.0382 0.0451
Trichomonas vaginalis glucosylceramidase, putative 0.0098 0.0354 0.0925
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0688 0.2929 0.9576
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.0085 0.0295 0.1308
Echinococcus multilocularis sterol regulatory element binding protein 0.0035 0.0078 0.0075
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0688 0.2929 0.9576
Leishmania major hypothetical protein, conserved 0.004 0.01 0.0314
Mycobacterium ulcerans hypothetical protein 0.0093 0.0332 0.1706
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0032 0.0028
Echinococcus granulosus ubiquitin specific protease 41 0.0118 0.0441 0.0438
Echinococcus multilocularis Niemann Pick C1 protein 0.0117 0.0436 0.0432
Onchocerca volvulus 0.0093 0.0332 0.0927
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0262 0.1071 0.1067
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0083 0.0095
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0893 0.3826 1
Loa Loa (eye worm) RNA binding protein 0.0042 0.0108 0.0124
Trypanosoma cruzi cysteine peptidase, putative 0.0688 0.2929 0.349
Leishmania major importin beta-1 subunit, putative 0.003 0.0055 0.0166
Entamoeba histolytica cysteine proteinase, putative 0.0688 0.2929 0.764
Echinococcus granulosus Protein patched homolog 1 0.0035 0.0078 0.0075
Loa Loa (eye worm) hypothetical protein 0.0171 0.0674 0.0799
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0086 0.03 0.0296
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0136 0.0519 0.0516
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0083 0.0095
Trichomonas vaginalis chromobox protein, putative 0.0046 0.0126 0.033
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0893 0.3826 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0024 0.0024
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0118 0.0441 0.1096
Echinococcus granulosus succinate semialdehyde dehydrogenase 0.0023 0.0024 0.0021
Loa Loa (eye worm) hypothetical protein 0.0171 0.0674 0.0799
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0315 0.1301 0.1298
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0027 0.0041 0.0044
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0036 0.0095
Loa Loa (eye worm) hypothetical protein 0.0035 0.0078 0.0089
Schistosoma mansoni hypothetical protein 0.0436 0.1829 0.1827
Toxoplasma gondii aldehyde dehydrogenase (NAD) family protein 0.0023 0.0024 0.0065
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0036 0.0083 0.0259
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0033 0.0071 0.008
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0118 0.0441 0.0521
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0115 0.0427 0.1383
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0083 0.0259
Echinococcus granulosus apoptotic protease activating factor 1 0.0142 0.0546 0.0542
Loa Loa (eye worm) hypothetical protein 0.0257 0.1047 0.1245
Onchocerca volvulus Glucosylceramidase homolog 0.0098 0.0354 0.0989
Toxoplasma gondii cathepsin B 0.0717 0.3058 1
Loa Loa (eye worm) hypothetical protein 0.0229 0.0925 0.1099
Loa Loa (eye worm) hypothetical protein 0.0118 0.0441 0.0521
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0036 0.0083 0.0259
Schistosoma mansoni hypothetical protein 0.0436 0.1829 0.1827
Trypanosoma cruzi trypanothione reductase, putative 0.0105 0.0382 0.0451
Loa Loa (eye worm) ctsf protein 0.0688 0.2929 0.349
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0381 0.1588 0.5186
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0036 0.0083 0.0271
Mycobacterium tuberculosis Probable replicative DNA helicase DnaB 0.131 0.5647 0.9384
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0893 0.3826 1
Entamoeba histolytica hypothetical protein 0.0138 0.0529 0.1328
Trypanosoma brucei delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0023 0.0024 0.0065
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0033 0.0071 0.008
Toxoplasma gondii cathepsin CPC1 0.0171 0.0674 0.2193
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0024 0.0021
Echinococcus multilocularis caspase 2 0.0257 0.1047 0.1044
Onchocerca volvulus 0.0688 0.2929 0.8473
Toxoplasma gondii cathepsin CPC2 0.0171 0.0674 0.2193
Giardia lamblia Cysteine protease 0.0171 0.0674 0.1709
Loa Loa (eye worm) hypothetical protein 0.0171 0.0674 0.0799
Echinococcus multilocularis chromobox protein 1 0.0046 0.0126 0.0123
Brugia malayi Latrophilin receptor protein 2 0.0073 0.0244 0.0286
Echinococcus granulosus mitogen activated protein kinase 0.0033 0.0071 0.0068
Plasmodium falciparum serine repeat antigen 2 0.0171 0.0674 0.229
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0171 0.0674 0.1761
Loa Loa (eye worm) hypothetical protein 0.0171 0.0674 0.0799
Schistosoma mansoni tar DNA-binding protein 0.0042 0.0108 0.0104
Trichomonas vaginalis maltase-glucoamylase, putative 0.0079 0.0269 0.0702
Echinococcus granulosus beta LACTamase domain containing family member 0.0093 0.0332 0.0329
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0171 0.0674 0.1761
Trypanosoma cruzi trypanothione reductase, putative 0.0036 0.0083 0.0095
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0038 0.0099
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0103 0.0376 0.0373
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0098 0.0321
Trypanosoma brucei recA bacterial DNA recombination protein, putative 0.0026 0.0039 0.0114
Entamoeba histolytica cysteine proteinase, putative 0.0381 0.1588 0.4114
Echinococcus multilocularis cathepsin L 0.0171 0.0674 0.0671
Schistosoma mansoni cathepsin F (C01 family) 0.0688 0.2929 0.2927
Giardia lamblia Kinase, CMGC MAPK 0.0033 0.0071 0.0124
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0083 0.0095
Loa Loa (eye worm) cysteine protease 0.0688 0.2929 0.349
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0024 0.0021
Schistosoma mansoni ap endonuclease 0.004 0.0098 0.0095
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0023 0.0024 0.0024
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0023 0.0024 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0003 0.0009
Trypanosoma cruzi cysteine proteinase, putative 0.0381 0.1588 0.189
Brugia malayi hypothetical protein 0.0023 0.0024 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0171 0.0674 0.1761
Brugia malayi Papain family cysteine protease containing protein 0.0688 0.2929 0.349
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0098 0.0194
Echinococcus multilocularis cathepsin b 0.1937 0.8384 0.8383
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0171 0.0674 0.229
Loa Loa (eye worm) cathepsin B 0.0717 0.3058 0.3645
Onchocerca volvulus Cathepsin F homolog 0.0688 0.2929 0.8473
Entamoeba histolytica cysteine protease, putative 0.0381 0.1588 0.4114
Loa Loa (eye worm) hypothetical protein 0.0158 0.0614 0.0728
Echinococcus granulosus X box binding protein 1 0.0165 0.0644 0.064
Trypanosoma cruzi cruzipain precursor, putative 0.0688 0.2929 0.349
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0688 0.2929 0.7655
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0171 0.0674 0.1761
Entamoeba histolytica cysteine proteinase, putative 0.0381 0.1588 0.4114
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0036 0.0095
Echinococcus multilocularis zinc finger protein 0.0022 0.002 0.0017
Plasmodium falciparum thioredoxin reductase 0.0105 0.0382 0.1291
Entamoeba histolytica cysteine proteinase 2 0.0381 0.1588 0.4114
Loa Loa (eye worm) hypothetical protein 0.0023 0.0024 0.0024
Echinococcus multilocularis protein patched 0.0035 0.0078 0.0075
Plasmodium vivax metacaspase 1, putative 0.0115 0.0427 0.1445
Brugia malayi Cell death protein 3 precursor 0.0257 0.1047 0.1245
Onchocerca volvulus 0.0111 0.0409 0.1151
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0023 0.0024 0.0024
Echinococcus multilocularis caspase 8 0.0115 0.0427 0.0423
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0023 0.0024 0.0065
Schistosoma mansoni cathepsin C 0.0171 0.0674 0.0671
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0688 0.2929 0.7655
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0171 0.0674 0.0799
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0023 0.0024 0.0024
Brugia malayi Glycosyl hydrolases family 31 protein 0.0354 0.1473 0.1753
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0688 0.2929 0.7655
Echinococcus multilocularis geminin 0.0436 0.1829 0.1827
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0688 0.2929 0.7655
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0023 0.0027 0.0024
Brugia malayi Bromodomain containing protein 0.0034 0.0073 0.0082
Brugia malayi hypothetical protein 0.0117 0.0438 0.0518
Onchocerca volvulus 0.0808 0.3454 1
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.1395 0.6017 1
Brugia malayi glutaminase DH11.1 0.0359 0.1492 0.1775
Brugia malayi latrophilin 2 splice variant baaae 0.0158 0.0614 0.0728
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.007 0.023 0.027
Echinococcus multilocularis cysteine protease 0.0688 0.2929 0.2927
Onchocerca volvulus 0.0688 0.2929 0.8473
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0231 0.0933 0.1108
Brugia malayi aldehyde dehydrogenase 0.0023 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0062 0.0198 0.0231
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0171 0.0674 0.1709
Leishmania major cathepsin L-like protease 0.0688 0.2929 0.9576
Plasmodium falciparum serine repeat antigen 4 0.0171 0.0674 0.229
Loa Loa (eye worm) hypothetical protein 0.0231 0.0933 0.1108
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0171 0.0674 0.1709
Trichomonas vaginalis glucosylceramidase, putative 0.0103 0.0377 0.0985
Echinococcus multilocularis Protein lozenge 0.004 0.01 0.0096
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0023 0.0024 0.0024
Trypanosoma cruzi cruzipain precursor, putative 0.0209 0.0839 0.0997
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0083 0.0095
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0171 0.0674 0.1761
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0339 0.0335
Echinococcus granulosus GTP binding nuclear protein Ran 0.0027 0.0043 0.0039
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0688 0.2929 0.7655
Schistosoma mansoni hypothetical protein 0.0073 0.0244 0.024
Brugia malayi Pre-SET motif family protein 0.071 0.3027 0.3607
Trypanosoma cruzi cysteine peptidase, putative 0.0688 0.2929 0.349
Leishmania major cathepsin L-like protease 0.0688 0.2929 0.9576
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0023 0.0027 0.0024
Schistosoma mansoni chromobox protein 0.0046 0.0126 0.0123
Trichomonas vaginalis CMGC family protein kinase 0.0033 0.0071 0.0186
Mycobacterium tuberculosis Probable reductase 0.0239 0.0967 0.1601
Trichomonas vaginalis conserved hypothetical protein 0.0115 0.0427 0.1115
Loa Loa (eye worm) hypothetical protein 0.0093 0.0332 0.0392
Brugia malayi Ets-domain containing protein 0.007 0.023 0.027
Leishmania major alpha glucosidase II subunit, putative 0.0079 0.0269 0.0866
Brugia malayi Cathepsin L-like cysteine proteinase 0.0478 0.2015 0.2399
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0036 0.0095
Mycobacterium ulcerans glutaminase 0.0359 0.1492 0.8123
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0036 0.0095
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0036 0.0083 0.0271
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0893 0.3826 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0028 0.0048 0.0045
Trichomonas vaginalis importin beta-1, putative 0.003 0.0055 0.0143
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0073 0.0244 0.024
Loa Loa (eye worm) hypothetical protein 0.0082 0.0282 0.0332
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0093 0.0332 0.0329
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0171 0.0674 0.0671
Loa Loa (eye worm) glutaminase 2 0.0359 0.1492 0.1775
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0027 0.0043 0.0046
Loa Loa (eye worm) hypothetical protein 0.0026 0.0038 0.004
Schistosoma mansoni microtubule-associated protein tau 0.2307 1 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0596 0.2527 0.4195
Loa Loa (eye worm) hypothetical protein 0.0042 0.0109 0.0125
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0239 0.0967 0.1601
Schistosoma mansoni caspase-7 (C14 family) 0.0262 0.1071 0.1067
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0171 0.0674 0.1761
Loa Loa (eye worm) hypothetical protein 0.02 0.08 0.095
Trypanosoma brucei metacaspase 5, putative 0.0115 0.0427 0.1383
Mycobacterium tuberculosis Probable pyrroline-5-carboxylate dehydrogenase RocA 0.0023 0.0024 0.0033
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0688 0.2929 0.7655
Loa Loa (eye worm) hypothetical protein 0.0478 0.2015 0.2399
Loa Loa (eye worm) MH2 domain-containing protein 0.0103 0.0374 0.0442
Loa Loa (eye worm) hypothetical protein 0.0115 0.0427 0.0504
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0717 0.3058 0.3645
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0098 0.0112
Brugia malayi CHE-14 protein 0.0035 0.0078 0.0089
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0058
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0118 0.0441 0.0438
Echinococcus multilocularis neuropeptide s receptor 0.0316 0.1307 0.1303
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0239 0.0967 0.1601
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0038 0.0099
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0103 0.0376 0.1219
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0118 0.0442 0.0439
Schistosoma mansoni aldehyde dehydrogenase 0.0412 0.1725 0.1722
Echinococcus granulosus single minded 2 0.0026 0.0038 0.0035
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0024 0.0021
Echinococcus granulosus neuropeptide receptor A26 0.0316 0.1307 0.1303
Echinococcus granulosus mitogen activated protein kinase 3 0.0033 0.0071 0.0068
Giardia lamblia Cysteine protease 0.0171 0.0674 0.1709
Echinococcus multilocularis snurportin 1 0.0391 0.1633 0.163
Giardia lamblia Cathepsin B precursor 0.0171 0.0674 0.1709
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0005 0.0013
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0171 0.0674 0.229
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0115 0.0427 0.1115
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0029 0.0053 0.0115
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0115 0.0427 0.1383
Leishmania major cathepsin L-like protease 0.0688 0.2929 0.9576
Echinococcus multilocularis chromobox protein 1 0.0046 0.0126 0.0123
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0086 0.03 0.0353
Onchocerca volvulus 0.0142 0.0546 0.1547
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0339 0.0335
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0893 0.3826 1
Schistosoma mansoni cpg binding protein 0.0085 0.0298 0.0294
Trichomonas vaginalis glucosylceramidase, putative 0.0098 0.0354 0.0925
Onchocerca volvulus Cathepsin L homolog 0.0171 0.0674 0.1919
Giardia lamblia Cysteine protease 0.0171 0.0674 0.1709
Loa Loa (eye worm) hypothetical protein 0.02 0.08 0.095
Brugia malayi Cathepsin L-like precursor 0.0688 0.2929 0.349
Mycobacterium ulcerans esterase/lipase LipP 0.0093 0.0332 0.1706
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0036 0.0083 0.0328
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0079 0.0269 0.0643
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.0053 0.0139
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0171 0.0674 0.0671
Echinococcus granulosus geminin 0.0436 0.1829 0.1827
Loa Loa (eye worm) hypothetical protein 0.0093 0.0332 0.0392
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0023 0.0024 0.0024
Trypanosoma brucei glucosidase, putative 0.0079 0.0269 0.0866
Loa Loa (eye worm) hypothetical protein 0.0171 0.0674 0.0799
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1937 0.8384 0.8383
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0354 0.1473 0.1753
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0171 0.0674 0.0671
Echinococcus granulosus tm gpcr rhodopsin 0.0315 0.1301 0.1298
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0103 0.0376 0.0373
Echinococcus multilocularis dnaJ subfamily B 0.1127 0.4848 0.4846
Schistosoma mansoni rab6-interacting 0.0023 0.0024 0.0021
Chlamydia trachomatis recombinase RecA 0.0085 0.0295 1
Toxoplasma gondii ABC1 family protein 0.0093 0.0332 0.1074
Entamoeba histolytica cysteine protease, putative 0.0381 0.1588 0.4114
Trichomonas vaginalis glucosylceramidase, putative 0.0098 0.0354 0.0925
Trichomonas vaginalis esterase, putative 0.0093 0.0332 0.0868
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0118 0.0442 0.0439
Plasmodium vivax thioredoxin reductase, putative 0.0105 0.0382 0.1291
Brugia malayi Importin beta-1 subunit 0.0037 0.0085 0.0097
Onchocerca volvulus 0.0026 0.0038 0.0072
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0033 0.0071 0.0219
Entamoeba histolytica cysteine protease, putative 0.0171 0.0674 0.1709
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0029 0.0053 0.0076
Schistosoma mansoni hypothetical protein 0.0073 0.0244 0.024
Onchocerca volvulus 0.0319 0.1318 0.379
Echinococcus granulosus snurportin 1 0.0391 0.1633 0.163
Echinococcus granulosus Niemann Pick C1 protein 0.0117 0.0436 0.0432
Trypanosoma cruzi metacaspase 5, putative 0.0115 0.0427 0.0504
Loa Loa (eye worm) latrophilin receptor protein 2 0.0073 0.0244 0.0286
Trichomonas vaginalis Importin beta-1 subunit, putative 0.003 0.0055 0.0143
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0171 0.0674 0.0799
Trypanosoma brucei hypothetical protein, conserved 0.0093 0.0332 0.1074
Mycobacterium leprae conserved hypothetical protein 0.0093 0.0332 0.1487
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0171 0.0674 0.0671
Schistosoma mansoni lipoxygenase 0.0095 0.0341 0.0337
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0688 0.2929 0.7655
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0171 0.0674 0.1709
Loa Loa (eye worm) runx1 0.004 0.01 0.0114
Echinococcus granulosus cathepsin L 0.0171 0.0674 0.0671
Trichomonas vaginalis glucosylceramidase, putative 0.015 0.0579 0.1512
Leishmania major glycosyl hydrolase-like protein 0.0029 0.0053 0.016
Echinococcus multilocularis ubiquitin specific protease 41 0.0118 0.0441 0.0438
Toxoplasma gondii HEAT repeat-containing protein 0.0037 0.0085 0.0265
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0138 0.0529 0.0526
Echinococcus granulosus importin subunit beta 1 0.0037 0.0085 0.0082
Plasmodium vivax vivapain-3 0.0381 0.1588 0.5416
Trypanosoma brucei importin beta-1 subunit, putative 0.0037 0.0085 0.0265
Loa Loa (eye worm) hypothetical protein 0.0117 0.0438 0.0518
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0171 0.0674 0.229
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0688 0.2929 0.7655
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0688 0.2929 1
Trypanosoma cruzi metacaspase, putative 0.0115 0.0427 0.0504
Plasmodium vivax glutathione reductase, putative 0.0105 0.0382 0.1291
Loa Loa (eye worm) fibroinase 0.0688 0.2929 0.349
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0079 0.0269 0.0702
Onchocerca volvulus 0.0478 0.2015 0.5816
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0115 0.0427 0.0504
Trypanosoma brucei Metacaspase-4 0.0115 0.0427 0.1383
Echinococcus granulosus expressed conserved protein 0.0077 0.0261 0.0257
Toxoplasma gondii methylmalonate-semialdehyde dehydrogenase [acylating], putative 0.0023 0.0024 0.0065
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0412 0.1725 0.5634
Trichomonas vaginalis D-aminoacylase, putative 0.0093 0.0332 0.0868
Schistosoma mansoni tar DNA-binding protein 0.0042 0.0108 0.0104
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0093 0.0332 0.0329
Entamoeba histolytica hypothetical protein 0.0138 0.0529 0.1328
Loa Loa (eye worm) aldehyde dehydrogenase 4 0.0023 0.0024 0.0024
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0086 0.03 0.0353
Trichomonas vaginalis alpha-glucosidase, putative 0.0079 0.0269 0.0702
Trichomonas vaginalis glutathione reductase, putative 0.0036 0.0083 0.0218
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.0053 0.0139
Onchocerca volvulus 0.0093 0.0332 0.0927
Echinococcus multilocularis lysosomal alpha glucosidase 0.0354 0.1473 0.147
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0004 0.0001
Echinococcus granulosus cathepsin L 0.0381 0.1588 0.1585
Brugia malayi cathepsin L-like precursor 0.0478 0.2015 0.2399
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0033 0.0071 0.0219
Plasmodium falciparum ataxin-2 like protein, putative 0.004 0.01 0.0328
Loa Loa (eye worm) hypothetical protein 0.0156 0.0608 0.072
Schistosoma mansoni importin beta-1 0.0037 0.0085 0.0082
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0036 0.0083 0.008
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0078 0.0205
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1937 0.8384 1
Schistosoma mansoni hypothetical protein 0.0034 0.0073 0.0069
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0688 0.2929 0.7655
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0171 0.0674 0.1761
Trichomonas vaginalis mercuric reductase, putative 0.0036 0.0083 0.0218
Echinococcus granulosus aldehyde dehydrogenase family 3 member B1 0.0023 0.0024 0.0021
Loa Loa (eye worm) aldehyde dehydrogenase 0.0023 0.0024 0.0024
Plasmodium falciparum serine repeat antigen 1 0.0171 0.0674 0.229
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0717 0.3058 0.7993
Mycobacterium tuberculosis Conserved protein 0.0093 0.0332 0.0546
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0688 0.2929 0.7655
Echinococcus granulosus cathepsin L cysteine proteinase 0.0688 0.2929 0.2927
Schistosoma mansoni hypothetical protein 0.0138 0.0529 0.0526
Echinococcus multilocularis cysteine protease 0.0688 0.2929 0.2927
Schistosoma mansoni caspase-3 (C14 family) 0.0262 0.1071 0.1067
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0171 0.0674 0.1709
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0083 0.0095
Brugia malayi Cytochrome P450 family protein 0.0035 0.0076 0.0086
Brugia malayi PAS domain containing protein 0.0035 0.0078 0.0088
Schistosoma mansoni hypothetical protein 0.0165 0.0644 0.064
Mycobacterium tuberculosis Probable aldehyde dehydrogenase NAD dependent AldA (aldehyde dehydrogenase [NAD+]) 0.0023 0.0024 0.0033
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0033 0.0071 0.008
Giardia lamblia Cathepsin B precursor 0.0171 0.0674 0.1709
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0171 0.0674 0.0671
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0412 0.1725 0.2862
Toxoplasma gondii NADP-dependent succinate-semialdehyde dehydrogenase 0.0023 0.0024 0.0065
Loa Loa (eye worm) glutathione reductase 0.0105 0.0382 0.0451
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0032 0.0064 0.0072
Loa Loa (eye worm) hypothetical protein 0.0478 0.2015 0.2399
Trichomonas vaginalis glucosylceramidase, putative 0.015 0.0579 0.1512
Leishmania major pyrroline-5-carboxylate synthetase-like protein 0.0023 0.0024 0.0065
Brugia malayi Calcitonin receptor-like protein seb-1 0.0231 0.0933 0.1108
Entamoeba histolytica cysteine protease, putative 0.0381 0.1588 0.4114
Giardia lamblia Encystation-specific protease 0.0171 0.0674 0.1709
Loa Loa (eye worm) hypothetical protein 0.0171 0.0674 0.0799
Trypanosoma brucei metacaspase MCA3 0.0115 0.0427 0.1383
Schistosoma mansoni hypothetical protein 0.0034 0.0073 0.0069
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0118 0.0441 0.1096
Loa Loa (eye worm) hypothetical protein 0.0043 0.0113 0.013
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0118 0.0441 0.0438
Onchocerca volvulus 0.0688 0.2929 0.8473
Onchocerca volvulus 0.0688 0.2929 0.8473
Trypanosoma cruzi PAB1-binding protein , putative 0.004 0.01 0.0114
Brugia malayi RNA recognition motif domain containing protein 0.0042 0.0108 0.0124
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0083 0.0095
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0032 0.0064 0.006
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0023 0.0024 0.0024
Trichomonas vaginalis maltase-glucoamylase, putative 0.0029 0.0053 0.0139
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0026 0.0038 0.0071
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0269 0.0316
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0231 0.0933 0.1108
Brugia malayi Papain family cysteine protease containing protein 0.0171 0.0674 0.0799
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0239 0.0967 0.1601
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0118 0.0441 0.0521
Giardia lamblia Cysteine protease 0.0171 0.0674 0.1709
Brugia malayi Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor 0.0023 0.0024 0.0024
Schistosoma mansoni hypothetical protein 0.0018 0.0005 0.0001
Trichomonas vaginalis alpha-glucosidase, putative 0.0079 0.0269 0.0702
Mycobacterium tuberculosis Probable aldehyde dehydrogenase AldC 0.0023 0.0024 0.0033
Brugia malayi hypothetical protein 0.0138 0.0529 0.0626
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0115 0.0427 0.1115
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0115 0.0427 0.1115
Schistosoma mansoni chromobox protein 0.0046 0.0126 0.0123
Brugia malayi bHLH-PAS transcription factor 0.0026 0.0038 0.0041
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0093 0.0332 0.0392
Brugia malayi Thioredoxin reductase 0.0105 0.0382 0.0451
Brugia malayi Glycosyl hydrolases family 31 protein 0.0029 0.0053 0.0058
Toxoplasma gondii NADPH-glutathione reductase 0.0036 0.0083 0.0259
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0436 0.1831 0.3038
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0028 0.0048 0.0045

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 85 nM BindingDB_Patents: Binding Assay. The synthesized substances were examined in a PAR1 binding test. This tested whether the substances can inhibit the binding of a radioactively labeled PAR1 agonist known from the literature at the PAR1 receptor (Ho-Sam Ahn, Mol Pharm, 51:350-356, 1997).The human PAR1 receptor was expressed transiently in High Five insect cells. From these cells, after 48 hours, a membrane preparation was produced by standard methods, aliquoted into 10 mM Tris-HCl; 0.3 mM EDTA; 1 mM EGTA; 250 mM sucrose pH 7.5, and stored at -80 C.The substances were preincubated with the membrane at RT for 15 minutes, then the radioligand (ALA-(para-F-Phe)-Arg-ChA-homoArg-(3,4-3H-Tyr)-NH2; approx. 40 Ci/mMol) was added. The end concentration of the radioligand in the test buffer (50 mM Tris-HCl; 10 mM MgCl2; 1 mM EGTA; 0.1% BSA; 2% DMSO) was 20 nM, that of the membrane 1 mg/ml. After an incubation time of 60 minutes, 25 uL of the mixture were transferred to a 96-well MultiScreenHTS FB microtiter filtration. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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