Detailed information for compound 265387

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 430.496 | Formula: C21H23FN4O3S
  • H donors: 1 H acceptors: 3 LogP: 0.81 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1[C@H](C)CN(C[C@@H]1C)c1c(F)cc2c3c1N(C)Cc1n3c(c(c2=O)C(=O)O)sc1
  • InChi: 1S/C21H23FN4O3S/c1-10-6-25(7-11(2)24(10)4)17-14(22)5-13-16-18(17)23(3)8-12-9-30-20(26(12)16)15(19(13)27)21(28)29/h5,9-11H,6-8H2,1-4H3,(H,28,29)/t10-,11+
  • InChiKey: HYNJHFYBNHVNKB-PHIMTYICSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0036 0.012 0.0208
Echinococcus multilocularis epidermal growth factor receptor 0.0502 0.2926 0.292
Schistosoma mansoni phosphatidylserine receptor 0.0033 0.0105 0.0096
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.0236 0.0427
Brugia malayi Inositol-1 0.0078 0.0376 0.0681
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0299 0.1705 0.1697
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0018 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.0031 0.0089 0.0151
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.004 0.0146 0.0136
Loa Loa (eye worm) CHromoDomain protein family member 0.0021 0.0032 0.0048
Echinococcus multilocularis cdgsh iron sulfur domain containing protein 0.0255 0.1439 0.143
Schistosoma mansoni nAChR subunit 0.0018 0.0016 0.0006
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0018 0.0016 0.0006
Trichomonas vaginalis mercuric reductase, putative 0.0022 0.0034 0.0076
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0056 0.0241 0.0232
Entamoeba histolytica hypothetical protein 0.0022 0.0035 0.0124
Schistosoma mansoni nAChR subunit 0.004 0.0146 0.0136
Echinococcus multilocularis inositol monophosphatase 1 0.0078 0.0376 0.0367
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0027 0.0066 0.0146
Brugia malayi ImpB/MucB/SamB family protein 0.008 0.0386 0.0698
Brugia malayi Furin-like cysteine rich region family protein 0.0934 0.5522 1
Leishmania major protein kinase, putative 0.0027 0.0066 0.0726
Echinococcus granulosus CAAX prenyl protease 2 0.0094 0.047 0.0461
Loa Loa (eye worm) cytochrome P450 0.0018 0.0016 0.0019
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0023 0.0015
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0018 0.0011 0.0024
Echinococcus granulosus lysine specific demethylase 5A 0.0133 0.0707 0.0698
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.0019
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.006 0.0269 0.0259
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0056 0.0241 0.0232
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0021 0.0032 0.0022
Entamoeba histolytica hypothetical protein 0.004 0.0143 0.0685
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0051 0.0124
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0046 0.0183 0.0368
Brugia malayi hypothetical protein 0.0018 0.0016 0.0029
Schistosoma mansoni single-minded 0.0103 0.0526 0.0516
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0016 0.0223
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.0019
Loa Loa (eye worm) hypothetical protein 0.0081 0.0391 0.0699
Loa Loa (eye worm) hypothetical protein 0.0368 0.2119 0.3832
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0022 0.0034 0.0612
Echinococcus granulosus cpg binding protein 0.0159 0.0862 0.0853
Brugia malayi Pre-SET motif family protein 0.01 0.0506 0.0917
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0018 0.0016 0.0006
Schistosoma mansoni chromobox protein 0.0077 0.0365 0.0356
Loa Loa (eye worm) flap endonuclease-1 0.0029 0.0079 0.0134
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0018 0.0016 0.0025
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0025 0.0054 0.0236
Trichomonas vaginalis flap endonuclease-1, putative 0.0029 0.0079 0.0175
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0023 0.0013
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0378 0.2177 0.2169
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0041 0.0151 0.0142
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0125 0.0655 0.0646
Echinococcus granulosus insulin receptor 0.0299 0.1705 0.1697
Loa Loa (eye worm) hypothetical protein 0.004 0.0146 0.0254
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0143 0.0133
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0289 0.4059
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0068 0.0314 0.722
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0023 0.0015
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0023 0.0013
Trypanosoma cruzi DNA polymerase kappa, putative 0.0111 0.057 0.8027
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0063 0.0285 0.0924
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0018 0.0016 0.0006
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0051 0.0124
Brugia malayi Cytochrome P450 family protein 0.0018 0.0016 0.0029
Loa Loa (eye worm) hypothetical protein 0.0024 0.0051 0.0083
Schistosoma mansoni cpg binding protein 0.015 0.081 0.0801
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0021 0.0032 0.0022
Onchocerca volvulus 0.0031 0.0092 0.0169
Loa Loa (eye worm) hypothetical protein 0.0033 0.0105 0.0181
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0022 0.0034 0.0484
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0073 0.0345 0.1123
Echinococcus multilocularis glycine receptor subunit alpha 1 0.004 0.0146 0.0136
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0023 0.0031
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.008 0.0386 0.0377
Loa Loa (eye worm) hypothetical protein 0.0022 0.0035 0.0053
Onchocerca volvulus 0.0087 0.043 0.0916
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.01 0.0506 0.0497
Brugia malayi hypothetical protein 0.0228 0.1279 0.2316
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0022 0.0034 0.0025
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0126 0.0664 0.1202
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0081 0.1646
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0027 0.0066 0.0057
Loa Loa (eye worm) inositol-1 0.0078 0.0376 0.0672
Echinococcus granulosus beta LACTamase domain containing family member 0.0081 0.0391 0.0382
Trypanosoma cruzi trypanothione reductase, putative 0.0022 0.0034 0.0484
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0075 0.0166
Echinococcus granulosus inositol monophosphatase 1 0.0078 0.0376 0.0367
Plasmodium falciparum JmjC domain-containing protein, putative 0.0033 0.0105 0.2229
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0023 0.0013
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.004 0.0146 0.0264
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0018 0.0016 0.0025
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0023 0.0013
Onchocerca volvulus 0.0113 0.0582 0.125
Echinococcus multilocularis 0.0018 0.0016 0.0006
Echinococcus granulosus intermediate filament protein 0.0031 0.0092 0.0083
Onchocerca volvulus 0.004 0.0146 0.0286
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0073 0.0345 0.1103
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0034 0.0484
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0023 0.0041
Loa Loa (eye worm) hypothetical protein 0.002 0.0023 0.0031
Mycobacterium ulcerans beta-lactamase 0.0081 0.0391 0.1261
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0034 0.0484
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0018 0.0011 0.0001
Onchocerca volvulus 0.0081 0.0391 0.0828
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0047 0.0185 0.0408
Trypanosoma cruzi DNA polymerase kappa, putative 0.0111 0.057 0.8027
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0066 0.0146
Loa Loa (eye worm) hypothetical protein 0.0081 0.0391 0.0699
Onchocerca volvulus 0.0081 0.0391 0.0828
Schistosoma mansoni jumonji domain containing protein 0.0125 0.0655 0.0646
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.012 0.011
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0023 0.0041
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0033 0.0105 0.0549
Loa Loa (eye worm) hypothetical protein 0.002 0.0023 0.0031
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0056 0.0241 0.0232
Loa Loa (eye worm) hypothetical protein 0.0024 0.0051 0.0083
Loa Loa (eye worm) glutathione reductase 0.0062 0.0279 0.0495
Brugia malayi hypoxia-induced factor 1 0.0319 0.1826 0.3306
Echinococcus multilocularis RUN 0.0087 0.043 0.0421
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0018 0.0016 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.011 0.0242
Brugia malayi hypothetical protein 0.0018 0.0016 0.0029
Brugia malayi Death domain containing protein 0.003 0.0088 0.016
Entamoeba histolytica hypothetical protein 0.0018 0.0012 0.0005
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0081 0.1135
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0022 0.0034 0.0068
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.004 0.0146 0.0254
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0143 0.0133
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.004 0.0146 0.0264
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.001 0.0008
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0068 0.0314 0.6091
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.0019
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0016
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0018 0.0016 0.0223
Echinococcus granulosus Aminotransferase class III 0.0073 0.0345 0.0336
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0051 0.0092
Loa Loa (eye worm) hypoxia-induced factor 1 0.0319 0.1826 0.33
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0023 0.0013
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0299 0.1705 0.1697
Brugia malayi beta-lactamase 0.0081 0.0391 0.0708
Echinococcus multilocularis lysine specific demethylase 5A 0.0125 0.0655 0.0646
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.0019
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0021
Trypanosoma brucei DNA polymerase kappa, putative 0.0088 0.0432 0.6073
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.004 0.0146 0.0264
Echinococcus multilocularis polycomb protein SCMH1 0.0053 0.0224 0.0215
Loa Loa (eye worm) MBCTL1 0.006 0.0269 0.0477
Echinococcus multilocularis dna polymerase eta 0.0134 0.0711 0.0702
Plasmodium falciparum DNA repair protein REV1, putative 0.0025 0.0054 0.1014
Loa Loa (eye worm) jmjC domain-containing protein 0.0033 0.0105 0.0181
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0515 0.3001 0.661
Plasmodium vivax protease, putative 0.0019 0.0022 0.0149
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0023 0.0013
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0282 0.0501
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0165 0.0897 0.2951
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0018 0.0016 0.0006
Trypanosoma cruzi DNA polymerase eta, putative 0.0079 0.0379 0.5335
Mycobacterium tuberculosis Conserved protein 0.0081 0.0391 0.1275
Trypanosoma cruzi peptidase with unknown catalytic mechanism (family U48) 0.0094 0.047 0.661
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0032 0.01 0.0518
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0027 0.0066 0.0057
Schistosoma mansoni nAChR subunit 0.0018 0.0016 0.0006
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.001 0.0017
Loa Loa (eye worm) hypothetical protein 0.002 0.0023 0.0031
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.0236 0.0427
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0239 0.3362
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0027 0.0066 0.0932
Echinococcus multilocularis lamin dm0 0.0031 0.0092 0.0083
Schistosoma mansoni nAChR subunit 0.004 0.0146 0.0136
Toxoplasma gondii aldehyde dehydrogenase 0.007 0.0327 0.1913
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0081 0.0391 0.0382
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0023 0.0013
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0056 0.0241 0.0232
Schistosoma mansoni rab6-interacting 0.0087 0.043 0.0421
Echinococcus multilocularis lipoxygenase domain containing protein 0.0087 0.043 0.0421
Trichomonas vaginalis D-aminoacylase, putative 0.0081 0.0391 0.0861
Brugia malayi Ets-domain containing protein 0.0081 0.0393 0.0711
Toxoplasma gondii CAAX amino terminal protease family protein 0.0019 0.0022 0.0035
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0338 0.1935 0.4262
Schistosoma mansoni tyrosine kinase 0.0502 0.2926 0.292
Brugia malayi hypothetical protein 0.0019 0.0018 0.0033
Brugia malayi polk-prov protein 0.0056 0.0239 0.0433
Echinococcus multilocularis dnaJ subfamily B 0.1679 1 1
Echinococcus multilocularis histone acetyltransferase MYST2 0.006 0.0269 0.0259
Trypanosoma brucei DNA damage repair protein, putative 0.0025 0.0054 0.0763
Echinococcus multilocularis glycine receptor subunit alpha 1 0.004 0.0146 0.0136
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0018 0.0016 0.0025
Entamoeba histolytica hypothetical protein 0.004 0.0143 0.0685
Loa Loa (eye worm) hypothetical protein 0.0214 0.1191 0.2148
Plasmodium falciparum ornithine aminotransferase 0.0073 0.0345 0.7964
Treponema pallidum methylgalactoside ABC transporter, periplasmic galactose-binding protein (mglB-1) 0.0308 0.1758 0.9076
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0678 0.3981 0.7206
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0023 0.0041
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0018 0.0016 0.0006
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0022 0.0034 0.0025
Echinococcus granulosus lipoxygenase domain containing protein 0.0087 0.043 0.0421
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.012 0.011
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0018 0.0016 0.0006
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0068 0.0314 0.0305
Loa Loa (eye worm) hypothetical protein 0.002 0.0023 0.0031
Onchocerca volvulus 0.0057 0.0249 0.0514
Schistosoma mansoni flap endonuclease-1 0.0026 0.0063 0.0053
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0016
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0282 0.0273
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0073 0.0345 0.1108
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.012 0.0217
Onchocerca volvulus 0.002 0.0023 0.0015
Mycobacterium ulcerans lipoprotein LpqF 0.0063 0.0285 0.0908
Trichomonas vaginalis inositol monophosphatase, putative 0.0078 0.0376 0.0828
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0023 0.0013
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0025 0.0056 0.0047
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0023 0.0013
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.01 0.0506 0.3019
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0022 0.0034 0.0484
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.004 0.0146 0.0264
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0282 0.3973
Trypanosoma cruzi cytochrome P450, putative 0.0037 0.0128 0.1795
Schistosoma mansoni jumonji/arid domain-containing protein 0.0133 0.0707 0.0698
Leishmania major DNA polymerase eta, putative 0.0134 0.0711 1
Echinococcus multilocularis raf serine:threonine protein kinase 0.0056 0.0244 0.0234
Loa Loa (eye worm) CXXC zinc finger family protein 0.015 0.081 0.1459
Echinococcus multilocularis glycine receptor subunit alpha 1 0.004 0.0146 0.0136
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0034 0.0484
Brugia malayi jmjC domain containing protein 0.0033 0.0105 0.019
Echinococcus granulosus cytochrome P450 2K1 0.0018 0.0016 0.0006
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0094 0.047 0.0461
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0022 0.0034 0.0411
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0051 0.0092
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0282 0.0501
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0073 0.0345 0.1108
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0023 0.0013
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0132 0.0698 0.2288
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0027 0.0066 0.0726
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0047 0.0185 0.0408
Echinococcus multilocularis epidermal growth factor receptor 0.0934 0.5522 0.5518
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0023 0.0041
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.008 0.0386 0.0377
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.004 0.0146 0.0254
Mycobacterium leprae conserved hypothetical protein 0.0081 0.0391 0.1256
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.004 0.0146 0.0136
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0214 0.1191 0.2156
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0113 0.0588 0.1055
Schistosoma mansoni aryl hydrocarbon receptor 0.0103 0.0526 0.0516
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.0019
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.007 0.0327 0.1041
Schistosoma mansoni tyrosine kinase 0.0299 0.1705 0.1697
Loa Loa (eye worm) hypothetical protein 0.01 0.0506 0.0908
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0327 0.1046
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0022 0.0035 0.0025
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0018 0.0016 0.0025
Brugia malayi Protein kinase domain containing protein 0.003 0.0088 0.016
Onchocerca volvulus Netrin receptor homolog 0.003 0.0088 0.016
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0018 0.0016 0.0006
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.004 0.0146 0.0136
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0056 0.0241 0.0427
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.006 0.0269 0.0259
Plasmodium vivax thioredoxin reductase, putative 0.0062 0.0279 0.537
Mycobacterium tuberculosis Probable hydrolase 0.0081 0.0391 0.1275
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0027 0.0066 0.1573
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.004 0.0146 0.0136
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.0019
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0073 0.0345 0.2027
Echinococcus granulosus dna polymerase kappa 0.0111 0.057 0.0561
Mycobacterium tuberculosis Conserved hypothetical protein 0.008 0.0386 0.1258
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.0019
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.0019
Schistosoma mansoni hypothetical protein 0.004 0.0143 0.0133
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0023 0.0013
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.003 0.0088 0.0151
Echinococcus granulosus glycine receptor subunit beta 0.004 0.0146 0.0136
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0081 0.0391 0.1261
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0016
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0051 0.0124
Loa Loa (eye worm) hypothetical protein 0.004 0.0146 0.0254
Schistosoma mansoni DNA polymerase eta 0.0134 0.0711 0.0702
Echinococcus multilocularis lamin 0.0031 0.0092 0.0083
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.0019
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.012 0.1686
Brugia malayi hypothetical protein 0.004 0.0143 0.0258
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0018 0.0011 0.0019
Echinococcus granulosus chromobox protein 1 0.0077 0.0365 0.0356
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0018 0.0011 0.0024
Echinococcus granulosus GA binding protein alpha chain 0.0081 0.0393 0.0384
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0051 0.0124
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0047 0.0185 0.0408
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0016 0.0029
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0051 0.0143
Loa Loa (eye worm) hypothetical protein 0.002 0.0023 0.0031
Brugia malayi Uncoordinated protein 44 0.003 0.0088 0.016
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0131 0.0237
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.004 0.0146 0.0136
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0022 0.0034 0.0268
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0073 0.0345 0.1108
Trypanosoma brucei chrX additional, unordered contigs 0.0025 0.0054 0.0763
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0041 0.0151 0.0142
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0029 0.0079 0.0391
Schistosoma mansoni tyrosine kinase 0.0496 0.2887 0.288
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0042 0.0157 0.0147
Echinococcus granulosus netrin receptor unc 5 0.003 0.0088 0.0079
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0023 0.0041
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.004 0.0146 0.0136
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0018 0.0011 0.0001
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0022 0.0034 0.0411
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0078 0.0376 0.5292
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0022 0.0035 0.0025
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.0236 0.0418
Loa Loa (eye worm) hypothetical protein 0.0069 0.0322 0.0574
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0081 0.1646
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0018 0.0011 0.0001
Brugia malayi jmjC domain containing protein 0.0033 0.0105 0.019
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0018 0.0011 0.0001
Entamoeba histolytica Flap nuclease, putative 0.0029 0.0079 0.0357
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0054 0.0763
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.012 0.011
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.011 0.0242
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0022 0.0035 0.0063
Echinococcus multilocularis cpg binding protein 0.0159 0.0862 0.0853
Trypanosoma cruzi cytochrome P450, putative 0.0037 0.0128 0.1795
Echinococcus granulosus glycine receptor subunit alpha 1 0.004 0.0146 0.0136
Schistosoma mansoni hypothetical protein 0.006 0.0264 0.0255
Schistosoma mansoni tyrosine kinase 0.0299 0.1705 0.1697
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0068 0.0314 0.4418
Loa Loa (eye worm) RNA binding protein 0.0063 0.0282 0.0501
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0338 0.1935 0.4262
Brugia malayi excitatory GABA receptor EXP-1A 0.004 0.0146 0.0264
Giardia lamblia Flap structure-specific endonuclease 0.0029 0.0079 0.0237
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.004 0.0146 0.0264
Trichomonas vaginalis penicillin-binding protein, putative 0.0081 0.0391 0.0861
Echinococcus granulosus lamin dm0 0.0031 0.0092 0.0083
Brugia malayi bHLH-PAS transcription factor 0.0076 0.0364 0.066
Mycobacterium leprae Possible regulatory protein 0.0027 0.0066 0.0169
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0022 0.0034 0.0087
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0378 0.2177 0.2169
Schistosoma mansoni hypothetical protein 0.027 0.1531 0.1523
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0018 0.0016 0.0006
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0018 0.0016 0.0019
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0018 0.0016 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.011 0.0242
Brugia malayi Cytochrome P450 family protein 0.0037 0.0128 0.0231
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0018 0.0011 0.0019
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.0008
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0056 0.0241 0.0436
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.001
Trichomonas vaginalis Clan U, family U48, CaaX prenyl peptidase 2-like 0.0094 0.047 0.1035
Echinococcus granulosus raf serine:threonine protein kinase 0.0056 0.0244 0.0234
Giardia lamblia DINP protein human, muc B family 0.0088 0.0432 0.2089
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0022 0.0034 0.0062
Giardia lamblia Fructose-bisphosphate aldolase 0.0338 0.1935 1
Onchocerca volvulus 0.0031 0.0092 0.0169
Brugia malayi beta-lactamase family protein 0.0081 0.0391 0.0708
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0111 0.057 0.1256
Echinococcus granulosus survival motor neuron protein 1 0.0228 0.1279 0.127
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.011 0.0242
Giardia lamblia Hypothetical protein 0.0094 0.047 0.229
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0022 0.0034 0.0484
Loa Loa (eye worm) hypothetical protein 0.004 0.0146 0.0254
Mycobacterium leprae Probable lipase LipE 0.0081 0.0391 0.1256
Schistosoma mansoni nuclear hormone receptor 0.002 0.0023 0.0013
Echinococcus granulosus histone lysine methyltransferase setb 0.01 0.0506 0.0497
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0054 0.0763
Trypanosoma brucei DNA polymerase kappa, putative 0.0111 0.057 0.8027
Schistosoma mansoni lamin 0.0031 0.0092 0.0083
Schistosoma mansoni hypothetical protein 0.0038 0.0131 0.0122
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.0019 0.0022 0.0044
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.0289 0.0279
Echinococcus multilocularis Polycystic kidney disease protein 0.0087 0.043 0.0421
Brugia malayi CAAX amino terminal protease family protein 0.0094 0.047 0.0851
Onchocerca volvulus 0.004 0.0146 0.0286
Trichomonas vaginalis helicase, putative 0.0034 0.011 0.0242
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0022 0.0034 0.0025
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.0289 0.0522
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0338 0.1935 0.4262
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0018 0.0016 0.0019
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.004 0.0146 0.0136
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0022 0.0034 0.0268
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0126 0.0664 0.2174
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0079 0.0379 0.2236
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0027 0.0066 0.0932
Echinococcus multilocularis Aminotransferase class III 0.0073 0.0345 0.0336
Mycobacterium ulcerans DNA polymerase IV 0.0111 0.057 0.1862
Loa Loa (eye worm) heterochromatin protein 1 0.0077 0.0365 0.0652
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.01 0.0506 0.0497
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0018 0.0011 0.0001
Loa Loa (eye worm) hypothetical protein 0.0031 0.009 0.0153
Plasmodium vivax DNA repair protein REV1, putative 0.0025 0.0054 0.0813
Echinococcus granulosus Polycystic kidney disease protein 0.0087 0.043 0.0421
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0023 0.0041
Schistosoma mansoni polycystin 1-related 0.0087 0.043 0.0421
Leishmania major DNA polymerase kappa, putative 0.0088 0.0432 0.5983
Loa Loa (eye worm) hypothetical protein 0.002 0.0023 0.0031
Brugia malayi hypothetical protein 0.0087 0.043 0.0779
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0023 0.0013
Mycobacterium ulcerans esterase/lipase LipP 0.0081 0.0391 0.1261
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0088 0.0432 0.5983
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0056 0.0241 0.0232
Loa Loa (eye worm) hypothetical protein 0.004 0.0146 0.0254
Echinococcus multilocularis survival motor neuron protein 1 0.0228 0.1279 0.127
Loa Loa (eye worm) hypothetical protein 0.0043 0.0163 0.0286
Loa Loa (eye worm) hypothetical protein 0.0346 0.1987 0.3592
Mycobacterium ulcerans L-lysine aminotransferase 0.0073 0.0345 0.1108
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0022 0.0034 0.0062
Loa Loa (eye worm) histone methyltransferase 0.005 0.0206 0.0364
Brugia malayi Immunoglobulin I-set domain containing protein 0.003 0.0088 0.016
Echinococcus multilocularis ornithine aminotransferase 0.0073 0.0345 0.0336
Loa Loa (eye worm) hypothetical protein 0.0027 0.0066 0.011
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.012 0.011
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0323 0.1846 0.1838
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0338 0.1935 0.4262
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0515 0.3001 0.9974
Schistosoma mansoni ankyrin 23/unc44 0.003 0.0088 0.0079
Mycobacterium tuberculosis Conserved protein 0.0081 0.0391 0.1275
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0092 0.0158
Echinococcus granulosus mixed lineage leukemia protein mll 0.0041 0.0151 0.0142
Brugia malayi Fli-1 protein 0.0246 0.1386 0.251
Loa Loa (eye worm) hypothetical protein 0.004 0.0146 0.0254
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0051 0.0508
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.004 0.0146 0.0264
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0023 0.0013
Schistosoma mansoni survival motor neuron protein 0.0047 0.0185 0.0176
Echinococcus multilocularis neuropeptide receptor A26 0.1077 0.6385 0.6382
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0156 0.0844 0.0836
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0047 0.0185 0.0408
Brugia malayi Latrophilin receptor protein 2 0.0017 0.001 0.0017
Leishmania major protein kinase, putative 0.0031 0.0093 0.1107
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.004 0.0146 0.0136
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.004 0.0146 0.0136
Schistosoma mansoni hypothetical protein 0.055 0.3211 0.3205
Brugia malayi hypothetical protein 0.0018 0.0016 0.0029
Brugia malayi nuclear receptor NHR-88 0.002 0.0023 0.0041
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0073 0.0345 0.1123
Echinococcus multilocularis flap endonuclease 1 0.0029 0.0079 0.007
Echinococcus granulosus tumor protein p63 0.039 0.2252 0.2245
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0022 0.0034 0.0087
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.004 0.0146 0.0264
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0092 0.0158
Plasmodium vivax ornithine aminotransferase, putative 0.0073 0.0345 0.6724
Echinococcus multilocularis microtubule associated protein 2 0.1464 0.8708 0.8707
Loa Loa (eye worm) mbt repeat family protein 0.0053 0.0224 0.0397
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0023 0.0041
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0073 0.0345 0.1108
Entamoeba histolytica deoxycytidyl transferase, putative 0.008 0.0386 0.1949
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.004 0.0146 0.0254
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0051 0.0118
Loa Loa (eye worm) hypothetical protein 0.0228 0.1279 0.2308
Echinococcus multilocularis insulin receptor 0.0299 0.1705 0.1697
Loa Loa (eye worm) hypothetical protein 0.004 0.0146 0.0254
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.004 0.0146 0.0264
Loa Loa (eye worm) ACC-1 protein 0.004 0.0146 0.0254
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.007 0.0327 0.0317
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0018 0.0016 0.0006
Echinococcus multilocularis lysine specific demethylase 6a 0.0033 0.0105 0.0096
Echinococcus multilocularis chromobox protein 1 0.0077 0.0365 0.0356
Loa Loa (eye worm) TK/EGFR protein kinase 0.0934 0.5522 1
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.004 0.0146 0.0136
Trypanosoma brucei trypanothione reductase 0.0062 0.0279 0.3919
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0126 0.0664 0.0655
Loa Loa (eye worm) hypothetical protein 0.0029 0.0081 0.0137
Schistosoma mansoni hypothetical protein 0.003 0.0088 0.0079
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.004 0.0146 0.0136
Mycobacterium ulcerans putative regulatory protein 0.0076 0.0364 0.1172
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0022 0.0035 0.0063
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0022 0.0034 0.0087
Echinococcus multilocularis neuropeptide s receptor 0.1077 0.6385 0.6382
Loa Loa (eye worm) beta-lactamase 0.0081 0.0391 0.0699
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0053 0.0224 0.0461
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0022 0.0034 0.0542
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0023 0.0031
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0092 0.0167
Loa Loa (eye worm) hypothetical protein 0.0081 0.0391 0.0699
Toxoplasma gondii ABC1 family protein 0.0081 0.0391 0.2308
Trichomonas vaginalis adenylate cyclase, putative 0.0027 0.0066 0.0146
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.011 0.0242
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0023 0.0015
Mycobacterium leprae Possible D-ribose-binding protein 0.0308 0.1758 0.5837
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.005 0.0206 0.0197
Echinococcus granulosus lipoxygenase domain containing protein 0.0087 0.043 0.0421
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0022 0.0035 0.0063
Echinococcus granulosus histone acetyltransferase MYST2 0.006 0.0269 0.0259
Schistosoma mansoni loxhd1 0.0087 0.043 0.0421
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0051 0.0508
Schistosoma mansoni hypothetical protein 0.0087 0.043 0.0421
Plasmodium vivax JmjC domain containing protein 0.0033 0.0105 0.1846
Onchocerca volvulus 0.0771 0.4542 1
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0088 0.0193
Loa Loa (eye worm) hypothetical protein 0.003 0.0088 0.0151
Schistosoma mansoni hypothetical protein 0.0047 0.0185 0.0176
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0053 0.0224 0.0215
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0033 0.0105 0.1478
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0515 0.3001 1
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0018 0.0016 0.0223
Loa Loa (eye worm) doublecortin family protein 0.0087 0.043 0.0771
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0054 0.0763
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0023 0.0041
Leishmania major hypothetical protein, conserved 0.0068 0.0314 0.4291
Schistosoma mansoni tyrosine kinase 0.0934 0.5522 0.5518
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0081 0.1135
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0018 0.0016 0.0006
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0022 0.0044
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0078 0.0376 0.5292
Onchocerca volvulus 0.0053 0.0224 0.0461
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0016
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0018 0.0016 0.0025
Trypanosoma cruzi DNA polymerase eta, putative 0.0134 0.0711 1
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0018 0.0016 0.0025
Trichomonas vaginalis chromobox protein, putative 0.0077 0.0365 0.0804
Loa Loa (eye worm) hypothetical protein 0.004 0.0146 0.0254
Loa Loa (eye worm) hypothetical protein 0.006 0.0269 0.0477
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.007 0.0327 0.1061
Echinococcus multilocularis glycine receptor subunit beta 0.004 0.0146 0.0136
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0018 0.0011 0.0024
Echinococcus multilocularis tumor protein p63 0.039 0.2252 0.2245
Brugia malayi Protein kinase domain containing protein 0.0299 0.1705 0.3087
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.004 0.0146 0.0136
Loa Loa (eye worm) cytochrome P450 family protein 0.0037 0.0128 0.0222
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.012 0.1686
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0127 0.0117
Entamoeba histolytica hypothetical protein 0.004 0.0143 0.0685
Trichomonas vaginalis hypothetical protein 0.0018 0.0015 0.0033
Brugia malayi SET domain containing protein 0.0019 0.0021 0.0039
Echinococcus multilocularis musashi 0.0031 0.0092 0.0083
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0338 0.1935 0.4262
Echinococcus multilocularis jumonji domain containing 1A 0.0033 0.0105 0.0096
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.094 0.5556 0.5552
Echinococcus granulosus JmjC domain containing protein 4 0.0033 0.0105 0.0096
Toxoplasma gondii histone lysine methyltransferase SET1 0.0289 0.1641 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0131 0.0228
Echinococcus multilocularis transfer RNA-Lys 0.0076 0.0364 0.0355
Toxoplasma gondii hypothetical protein 0.0019 0.0022 0.0035
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0018 0.0016 0.0025
Loa Loa (eye worm) hypothetical protein 0.0053 0.0224 0.0397
Schistosoma mansoni hypothetical protein 0.0323 0.1847 0.1839
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0073 0.0345 0.1123
Brugia malayi beta-lactamase family protein 0.0081 0.0391 0.0708
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.0289 0.1443
Brugia malayi jmjC domain containing protein 0.0033 0.0105 0.019
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0023 0.0013
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0018 0.0016 0.0025
Plasmodium vivax multidomain scavenger receptor, putative 0.0087 0.043 0.8455
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0047 0.0185 0.0408
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0023 0.0013
Trichomonas vaginalis esterase, putative 0.0081 0.0391 0.0861
Schistosoma mansoni ets-related 0.0246 0.1386 0.1378
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0027 0.0066 0.0932
Trichomonas vaginalis chromobox protein, putative 0.0077 0.0365 0.0804
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0023 0.0013
Schistosoma mansoni cpg binding protein 0.0159 0.0862 0.0853
Brugia malayi TAR-binding protein 0.0063 0.0282 0.0511
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0056 0.0241 0.0232
Echinococcus multilocularis JmjC domain containing protein 4 0.0033 0.0105 0.0096
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0022 0.0034 0.0542
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0018 0.0016 0.0025
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0282 0.0511
Schistosoma mansoni thyroid hormone receptor 0.002 0.0023 0.0013
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0018 0.0011 0.001
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0018 0.0016 0.0006
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.004 0.0146 0.0264
Onchocerca volvulus 0.0027 0.0066 0.0111
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0126 0.0664 0.2184
Trypanosoma cruzi DNA polymerase kappa, putative 0.0111 0.057 0.8027
Loa Loa (eye worm) GABA receptor subunit 0.0022 0.0035 0.0053
Mycobacterium ulcerans DNA polymerase IV 0.0111 0.057 0.1862
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0022 0.0034 0.0114
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0018 0.0016 0.0006
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0051 0.0118
Brugia malayi Uncharacterized hematopoietic stem/progenitor cells protein MDS029 0.0108 0.0557 0.1009
Trypanosoma brucei beta lactamase 0.0063 0.0285 0.4016
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0023 0.0041
Mycobacterium ulcerans hypothetical protein 0.0019 0.0022 0.0025
Schistosoma mansoni chromobox protein 0.0077 0.0365 0.0356
Plasmodium vivax hypothetical protein, conserved 0.0081 0.0391 0.7652
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0081 0.135
Loa Loa (eye worm) hypothetical protein 0.0033 0.0105 0.0181
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0081 0.0391 0.0699
Brugia malayi F/Y-rich N-terminus family protein 0.005 0.0203 0.0367
Loa Loa (eye worm) hypothetical protein 0.0081 0.0391 0.0699
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0029 0.0079 0.1117
Schistosoma mansoni myst-related protein 0.0018 0.0012 0.0002
Trypanosoma brucei DNA polymerase IV, putative 0.0111 0.057 0.8027
Trichomonas vaginalis guanylate cyclase, putative 0.0027 0.0066 0.0146
Loa Loa (eye worm) hypothetical protein 0.004 0.0146 0.0254
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0023 0.0013
Plasmodium falciparum LCCL domain-containing protein 0.0087 0.043 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.001
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.012 0.011
Schistosoma mansoni acetylcholine receptor subunit beta 0.0018 0.0016 0.0006
Loa Loa (eye worm) hypothetical protein 0.004 0.0146 0.0254
Echinococcus granulosus tar DNA binding protein 0.0063 0.0282 0.0273
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0027 0.0066 0.0146
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.011 0.0242
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0037 0.0128 0.038
Loa Loa (eye worm) hypothetical protein 0.004 0.0146 0.0254
Brugia malayi intermediate filament protein 0.0031 0.0092 0.0167
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0081 0.0391 0.1275
Loa Loa (eye worm) hypothetical protein 0.0055 0.0236 0.0418
Trypanosoma brucei DNA polymerase kappa, putative 0.0111 0.057 0.8027
Onchocerca volvulus 0.0108 0.0557 0.1195
Schistosoma mansoni microtubule-associated protein tau 0.1464 0.8708 0.8707
Trypanosoma brucei hypothetical protein, conserved 0.0081 0.0391 0.55
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0338 0.1935 0.4262
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0068 0.0314 0.0305
Echinococcus granulosus microtubule associated protein 2 0.1464 0.8708 0.8707
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0051 0.021
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0029 0.0079 0.0915
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0041 0.0151 0.0142
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0047 0.0185 0.0408
Mycobacterium ulcerans lipase LipD 0.0081 0.0391 0.1261
Schistosoma mansoni nAChR subunit 0.004 0.0146 0.0136
Schistosoma mansoni lamin 0.0031 0.0092 0.0083
Loa Loa (eye worm) thioredoxin reductase 0.0062 0.0279 0.0495
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0031 0.009 0.0199
Brugia malayi Doublecortin family protein 0.0087 0.043 0.0779
Loa Loa (eye worm) hypothetical protein 0.004 0.0146 0.0254
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0018 0.0011 0.0001
Schistosoma mansoni myst-related protein 0.0018 0.0012 0.0002
Brugia malayi N-terminal motif family protein 0.0204 0.1132 0.205
Loa Loa (eye worm) hypothetical protein 0.0022 0.0035 0.0053
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0165 0.0897 0.2955
Toxoplasma gondii NADPH-glutathione reductase 0.0022 0.0034 0.0114
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0063 0.0285 0.0903
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0209 0.1164 0.1156
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0113 0.0582 0.0573
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0282 0.3973
Brugia malayi Raf kinase 0.0056 0.0244 0.0441
Echinococcus multilocularis SAM and MBT domain containing protein 0.0053 0.0224 0.0215
Trypanosoma brucei DNA polymerase kappa, putative 0.0111 0.057 0.8027
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0018 0.0016 0.0006
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0081 0.0391 0.0382
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0022 0.0034 0.0484
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.012 0.0264
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0165 0.0897 0.2961
Mycobacterium tuberculosis Probable esterase LipL 0.0081 0.0391 0.1275
Leishmania major cytochrome p450-like protein 0.0037 0.0128 0.1608
Toxoplasma gondii hypothetical protein 0.0019 0.0022 0.0035
Echinococcus granulosus flap endonuclease 1 0.0029 0.0079 0.007
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0018 0.0016 0.0006
Toxoplasma gondii thioredoxin reductase 0.0062 0.0279 0.1617
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0132 0.0698 0.2297
Schistosoma mansoni inositol monophosphatase 0.0078 0.0376 0.0367
Trypanosoma brucei DNA polymerase kappa, putative 0.0056 0.0239 0.3362
Schistosoma mansoni lipoxygenase 0.0378 0.2177 0.2169
Schistosoma mansoni nAChR subunit 0.004 0.0146 0.0136
Mycobacterium tuberculosis Probable oxidoreductase 0.0022 0.0034 0.0087
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0033 0.0105 0.1478
Echinococcus granulosus nuclear factor of activated T cells 5 0.0156 0.0844 0.0836
Trichomonas vaginalis guanylate cyclase, putative 0.0027 0.0066 0.0146
Schistosoma mansoni phd/f-box containing protein 0.0033 0.0105 0.0096
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0023 0.0041
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.004 0.0146 0.0264
Echinococcus granulosus thioredoxin glutathione reductase 0.0062 0.0279 0.0269
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0088 0.0432 0.1411
Brugia malayi Pre-SET motif family protein 0.0678 0.3981 0.7208
Treponema pallidum methylgalactoside ABC transporter, periplasmic galactose-binding protein (mglB-2) 0.0308 0.1758 0.9076
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0033 0.0105 0.1478
Loa Loa (eye worm) hypothetical protein 0.0022 0.0035 0.0053
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0078 0.0376 0.5292
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.0019
Onchocerca volvulus 0.0022 0.0035 0.0041
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0126 0.0664 0.0655
Loa Loa (eye worm) LGC-31 protein 0.004 0.0146 0.0254
Brugia malayi hypothetical protein 0.0346 0.1987 0.3598
Plasmodium vivax glutathione reductase, putative 0.0062 0.0279 0.537
Loa Loa (eye worm) ACC-1 protein 0.004 0.0146 0.0254
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0023 0.0031
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.006 0.0269 0.0486
Brugia malayi Cation transporter family protein 0.004 0.0146 0.0264
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0018 0.0011 0.0001
Treponema pallidum fructose-bisphosphate aldolase 0.0338 0.1935 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.0019
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0338 0.1935 0.4262
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0068 0.0314 0.4418
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0041 0.0151 0.0142
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0027 0.0066 0.0932
Loa Loa (eye worm) acetylcholine receptor protein 0.0018 0.0016 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.011 0.0242
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0047 0.0185 0.0408
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0078 0.0376 0.5185
Trichomonas vaginalis glutathione reductase, putative 0.0022 0.0034 0.0076
Loa Loa (eye worm) hypothetical protein 0.0081 0.0391 0.0699
Echinococcus multilocularis beta LACTamase domain containing family member 0.0081 0.0391 0.0382
Echinococcus granulosus phd:f box containing protein 0.0033 0.0105 0.0096
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0073 0.0345 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0056 0.0241 0.0232
Loa Loa (eye worm) hypothetical protein 0.004 0.0146 0.0254
Brugia malayi Cation transporter family protein 0.004 0.0146 0.0264
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.004 0.0146 0.0136
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0018 0.0016 0.0006
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0018 0.0016 0.0006
Schistosoma mansoni nAChR subunit 0.004 0.0146 0.0136
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.011 0.0242
Schistosoma mansoni intermediate filament proteins 0.0031 0.0092 0.0083
Mycobacterium ulcerans integral membrane protein 0.0019 0.0022 0.0025
Brugia malayi ecdysteroid receptor 0.002 0.0023 0.0041
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0023 0.0031
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0018 0.0016 0.0006
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0022 0.0034 0.0068
Echinococcus granulosus chromobox protein 1 0.0077 0.0365 0.0356
Brugia malayi Ets-domain containing protein 0.0081 0.0393 0.0711
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0022 0.0034 0.0268
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0051 0.0124
Mycobacterium ulcerans hypothetical protein 0.0515 0.3001 1
Schistosoma mansoni rab6-interacting 0.0087 0.043 0.0421
Brugia malayi CHD4 protein 0.0021 0.0032 0.0058
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0018 0.0016 0.0006
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0018 0.0016 0.0006
Brugia malayi Thioredoxin reductase 0.0062 0.0279 0.0504
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0047 0.0185 0.0408
Brugia malayi Heterochromatin protein 1 0.0077 0.0365 0.0661
Echinococcus granulosus ornithine aminotransferase 0.0073 0.0345 0.0336
Loa Loa (eye worm) hypothetical protein 0.004 0.0146 0.0254
Schistosoma mansoni inositol monophosphatase 0.0078 0.0376 0.0367
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.012 0.0449
Loa Loa (eye worm) hypothetical protein 0.002 0.0023 0.0031
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.004 0.0146 0.0136
Toxoplasma gondii Erv1 / Alr family protein 0.0068 0.0314 0.1835
Echinococcus granulosus single minded 2 0.0076 0.0364 0.0355
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0023 0.0013
Echinococcus granulosus cdgsh iron sulfur domain containing protein 0.0255 0.1439 0.143
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0185 0.0335
Loa Loa (eye worm) hypothetical protein 0.0108 0.0557 0.1
Echinococcus multilocularis 0.0289 0.1641 0.1633
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0023 0.0013
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0014 0.0058
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0209 0.1164 0.1156
Loa Loa (eye worm) hypothetical protein 0.002 0.0023 0.0031
Schistosoma mansoni lipoxygenase 0.022 0.1231 0.1222
Trypanosoma brucei DNA polymerase eta, putative 0.0134 0.0711 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0111 0.057 0.8027
Loa Loa (eye worm) hepatopoietin HPO2 0.0068 0.0314 0.056
Schistosoma mansoni netrin receptor unc5 0.003 0.0088 0.0079
Echinococcus multilocularis GA binding protein alpha chain 0.0081 0.0393 0.0384
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0088 0.0193
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0081 0.0393 0.0702
Loa Loa (eye worm) hypothetical protein 0.0022 0.0035 0.0053
Brugia malayi ImpB/MucB/SamB family protein 0.0134 0.0711 0.1287
Schistosoma mansoni protein phosphatase 2C 0.0033 0.0105 0.0096
Echinococcus granulosus glycine receptor subunit alpha 1 0.004 0.0146 0.0136
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0051 0.0143
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.001
Echinococcus multilocularis thioredoxin glutathione reductase 0.0062 0.0279 0.0269
Echinococcus multilocularis chromobox protein 1 0.0077 0.0365 0.0356
Loa Loa (eye worm) hypothetical protein 0.004 0.0146 0.0254
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0125 0.0655 0.0646
Schistosoma mansoni nAChR subunit 0.004 0.0146 0.0136
Schistosoma mansoni neurotransmitter gated ion channel 0.0022 0.0035 0.0025
Loa Loa (eye worm) hypothetical protein 0.0057 0.0249 0.0441
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0016
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0018 0.0011 0.0001
Echinococcus granulosus lysine specific demethylase 6a 0.0033 0.0105 0.0096
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0078 0.0376 0.0828
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0066 0.0146
Onchocerca volvulus 0.015 0.081 0.1754
Plasmodium falciparum thioredoxin reductase 0.0062 0.0279 0.6372
Loa Loa (eye worm) hypothetical protein 0.0195 0.108 0.1947
Schistosoma mansoni coup transcription factor 0.002 0.0023 0.0013
Entamoeba histolytica CAAX prenyl protease family 0.0094 0.047 0.2385
Loa Loa (eye worm) CYP4Cod1 0.0037 0.0128 0.0222
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0023 0.0013
Echinococcus granulosus dna polymerase eta 0.0134 0.0711 0.0702
Leishmania major DNA damage repair protein, putative 0.0025 0.0054 0.0552
Leishmania major trypanothione reductase 0.0062 0.0279 0.3781
Trypanosoma brucei DNA polymerase kappa, putative 0.0111 0.057 0.8027
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0016 0.0223
Mycobacterium tuberculosis Probable lipase LipE 0.0081 0.0391 0.1275
Leishmania major hypothetical protein, conserved 0.0029 0.0081 0.0933
Plasmodium falciparum protease, putative 0.0019 0.0022 0.0234
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0078 0.0376 1
Echinococcus granulosus FTZ F1 alpha 0.002 0.0023 0.0013
Onchocerca volvulus 0.0024 0.0051 0.0078
Echinococcus granulosus RUN 0.0087 0.043 0.0421
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0282 0.0273
Onchocerca volvulus 0.0022 0.0035 0.0041
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0027 0.0066 0.0932
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.009 0.0199
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0126 0.0664 0.9322
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0018 0.0016 0.0006
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0163 0.0325
Mycobacterium ulcerans hypothetical protein 0.0024 0.0051 0.0124
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0034 0.0484
Echinococcus multilocularis lipoxygenase domain containing protein 0.0087 0.043 0.0421
Echinococcus granulosus neuropeptide s receptor 0.1077 0.6385 0.6382
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0289 0.4059
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0014 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.011 0.0242
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.008 0.0386 0.069
Echinococcus granulosus lamin 0.0031 0.0092 0.0083
Leishmania major hypothetical protein, conserved 0.0081 0.0391 0.5397
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0018 0.0011 0.0024
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0018 0.0016 0.0025
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0081 0.0391 0.1275
Schistosoma mansoni tyrosine kinase 0.0496 0.2887 0.288
Onchocerca volvulus 0.004 0.0146 0.0286
Echinococcus multilocularis dna polymerase kappa 0.0111 0.057 0.0561
Echinococcus multilocularis CAAX prenyl protease 2 0.0094 0.047 0.0461
Echinococcus multilocularis glycine receptor subunit beta 0.004 0.0146 0.0136
Brugia malayi glutathione reductase 0.0062 0.0279 0.0504
Brugia malayi hypothetical protein 0.0018 0.0016 0.0029
Trypanosoma cruzi hypothetical protein, conserved 0.0081 0.0391 0.55
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.0019 0.0022 0.0044
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0018 0.0016 0.0025
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0327 0.1046
Loa Loa (eye worm) hypothetical protein 0.0022 0.0035 0.0053
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0516 0.3009 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.007 0.0327 0.0317
Brugia malayi jmjC domain containing protein 0.0033 0.0105 0.019
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0023 0.0041
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0018 0.0016 0.0006
Trypanosoma cruzi CAAX prenyl protease 2, putative 0.0094 0.047 0.661
Echinococcus granulosus polycomb protein SCMH1 0.0053 0.0224 0.0215
Loa Loa (eye worm) hypothetical protein 0.004 0.0146 0.0254
Schistosoma mansoni hypothetical protein 0.1679 1 1
Schistosoma mansoni gabp alpha 0.0081 0.0393 0.0384
Onchocerca volvulus 0.004 0.0146 0.0286
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0018 0.0016 0.0025
Echinococcus granulosus nAChR subunit 0.0022 0.0035 0.0025
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0062 0.0279 0.0901
Loa Loa (eye worm) hypothetical protein 0.0087 0.043 0.0771
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0338 0.1935 1
Trypanosoma cruzi trypanothione reductase, putative 0.0062 0.0279 0.3919
Trypanosoma brucei unspecified product 0.0055 0.0237 0.3328
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0051 0.0092
Onchocerca volvulus 0.002 0.0024 0.0018
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0018 0.0011 0.0001
Schistosoma mansoni terminal deoxycytidyl transferase 0.008 0.0386 0.0377
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0023 0.0013
Echinococcus granulosus nAChR subunit 0.004 0.0146 0.0136
Onchocerca volvulus 0.0034 0.0107 0.0202
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0018 0.0016 0.0025
Treponema pallidum NADH oxidase 0.0022 0.0034 0.0067
Brugia malayi jmjC domain containing protein 0.0125 0.0655 0.1186
Mycobacterium ulcerans hypothetical protein 0.0019 0.0022 0.0025
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.007 0.0327 0.4475
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0078 0.0376 0.2217
Brugia malayi Cation transporter family protein 0.004 0.0146 0.0264
Onchocerca volvulus 0.0087 0.043 0.0916
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.012 0.1497
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0018 0.0016 0.0025
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0023 0.0013
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0033 0.0105 0.0096
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0066 0.0146
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0054 0.0763
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0023 0.0041
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0027 0.0066 0.0932
Entamoeba histolytica CAAX amino terminal protease family 0.0019 0.0022 0.0056
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0023 0.0041
Giardia lamblia DNA damage repair protein 0.0025 0.0054 0.0104
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0034 0.0484
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0023 0.0031
Brugia malayi hypothetical protein 0.0018 0.0016 0.0029
Loa Loa (eye worm) hypothetical protein 0.0024 0.0051 0.0083
Loa Loa (eye worm) raf kinase 0.005 0.0205 0.0361
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.01 0.0506 0.0497
Loa Loa (eye worm) hypothetical protein 0.0056 0.0239 0.0423
Loa Loa (eye worm) hypothetical protein 0.0087 0.043 0.0771
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.0019
Loa Loa (eye worm) hypothetical protein 0.0022 0.0035 0.0053
Schistosoma mansoni tyrosine kinase 0.0496 0.2887 0.288
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0027 0.0066 0.0146
Schistosoma mansoni cellular tumor antigen P53 0.0057 0.0249 0.0239
Leishmania major CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) 0.0094 0.047 0.6533
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0081 0.0391 0.1275
Trypanosoma brucei CAAX amino terminal protease, putative 0.0094 0.047 0.661
Trichomonas vaginalis chromobox protein, putative 0.0046 0.0183 0.0402
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.0019
Schistosoma mansoni DNA polymerase IV / kappa 0.0025 0.0054 0.0045
Trypanosoma brucei DNA polymerase IV, putative 0.0103 0.0525 0.7382
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0078 0.0376 0.1212
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0093 0.0465 0.0456
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0018 0.0016 0.0025
Loa Loa (eye worm) hypothetical protein 0.004 0.0146 0.0254
Schistosoma mansoni neurotransmitter gated ion channel 0.0018 0.0016 0.0006
Brugia malayi mbt repeat family protein 0.0053 0.0224 0.0406
Loa Loa (eye worm) cytochrome P450 family protein 0.0037 0.0128 0.0222
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.0289 0.3924
Schistosoma mansoni nAChR subunit 0.004 0.0146 0.0136
Loa Loa (eye worm) hypothetical protein 0.0081 0.0391 0.0699
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0224 0.0215
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.007 0.0327 0.1061
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0023 0.0041
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0018 0.0016 0.0029
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.0327 0.0317
Schistosoma mansoni hypothetical protein 0.0018 0.0016 0.0006
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0338 0.1935 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0078 0.0376 0.0828
Plasmodium falciparum flap endonuclease 1 0.0029 0.0079 0.1616
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0126 0.0664 0.2174
Loa Loa (eye worm) hypothetical protein 0.0022 0.0035 0.0053
Mycobacterium ulcerans hypothetical protein 0.0081 0.0391 0.1261
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0027 0.0066 0.011
Echinococcus granulosus epidermal growth factor receptor 0.0502 0.2926 0.292
Trichomonas vaginalis set domain proteins, putative 0.0771 0.4541 1
Brugia malayi cytochrome P450 0.0018 0.0016 0.0029
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0073 0.0345 0.9094
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0081 0.0391 0.0708
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.012 0.011
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0127 0.0117
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0078 0.0376 0.1899
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0073 0.0345 0.1123
Brugia malayi Cytochrome P450 family protein 0.0059 0.0259 0.0469
Trypanosoma brucei DNA polymerase kappa, putative 0.0111 0.057 0.8027
Echinococcus multilocularis Ankyrin 0.0031 0.009 0.008
Leishmania major DNA polymerase kappa, putative 0.0025 0.0054 0.0552
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0023 0.0013
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0018 0.0016 0.0025
Trichomonas vaginalis D-aminoacylase, putative 0.0081 0.0391 0.0861
Schistosoma mansoni myelin transcription factor 1 myt1 0.006 0.0269 0.0259
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.004 0.0146 0.0136
Plasmodium falciparum thioredoxin reductase 0.0022 0.0034 0.0542
Schistosoma mansoni cpg binding protein 0.0159 0.0862 0.0853
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0029 0.0079 0.1117
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.004 0.0146 0.0136
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.003 0.0088 0.0079
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0338 0.1935 0.4262
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0502 0.2926 0.292
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.004 0.0146 0.0264
Schistosoma mansoni CDGSH-type Zn finger-containing protein-like protein 0.027 0.1531 0.1523
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0034 0.0484
Chlamydia trachomatis hypothetical protein 0.0019 0.0022 0.0222
Echinococcus multilocularis nAChR subunit 0.0022 0.0035 0.0025
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.003 0.0088 0.0079
Plasmodium falciparum glutathione reductase 0.0062 0.0279 0.6372
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.0019
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0051 0.021
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0023 0.0013
Onchocerca volvulus 0.0076 0.0364 0.0769
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.0289 0.0279
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.004 0.0146 0.0264
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0023 0.0041
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0018 0.0016 0.0025
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0094 0.047 0.0461
Loa Loa (eye worm) hypothetical protein 0.0022 0.0035 0.0053
Trichomonas vaginalis D-aminoacylase, putative 0.0081 0.0391 0.0861
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0282 0.0273
Trypanosoma cruzi DNA polymerase kappa, putative 0.0111 0.057 0.8027
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0289 0.4059
Loa Loa (eye worm) hypothetical protein 0.0134 0.0711 0.1279
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0327 0.1046
Loa Loa (eye worm) jmjC domain-containing protein 0.0133 0.0707 0.1272
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0068 0.0314 0.4418
Loa Loa (eye worm) hypothetical protein 0.004 0.0146 0.0254
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0515 0.3001 1
Schistosoma mansoni cytochrome P450 0.0018 0.0016 0.0006
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0051 0.0508
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0282 0.0273
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.004 0.0146 0.0264
Onchocerca volvulus 0.004 0.0146 0.0286
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0018 0.0016 0.0029
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0126 0.0664 0.0655
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0021 0.0032 0.0022
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0005 0.001
Echinococcus granulosus Ankyrin 0.0031 0.009 0.008
Schistosoma mansoni jumonji domain containing protein 0.0033 0.0105 0.0096
Brugia malayi Augmenter of liver regeneration 0.0068 0.0314 0.0569
Entamoeba histolytica hypothetical protein 0.004 0.0143 0.0685
Schistosoma mansoni acetylcholine receptor-related 0.0018 0.0016 0.0006
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0022 0.0034 0.0068
Trichomonas vaginalis DNA polymerase eta, putative 0.0111 0.057 0.1256
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0081 0.1135
Echinococcus granulosus glycine receptor subunit beta 0.004 0.0146 0.0136
Brugia malayi jmjC domain containing protein 0.0133 0.0707 0.128
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0051 0.021
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0023 0.0013
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0018 0.0011 0.0001
Onchocerca volvulus 0.004 0.0146 0.0286
Brugia malayi Flap endonuclease-1 0.0029 0.0079 0.0144
Echinococcus granulosus neuropeptide receptor A26 0.1077 0.6385 0.6382
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.012 0.0264
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.0289 0.0513
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.0289 0.0279
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0018 0.0016 0.0025
Trichomonas vaginalis penicillin-binding protein, putative 0.0081 0.0391 0.0861
Mycobacterium tuberculosis Probable aminotransferase 0.0515 0.3001 0.9974
Onchocerca volvulus Putative nachr subunit 0.004 0.0146 0.0286
Echinococcus multilocularis aryl hydrocarbon receptor 0.0027 0.0066 0.0057
Loa Loa (eye worm) hypothetical protein 0.0031 0.0092 0.0158
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.012 0.0264
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.004 0.0146 0.0264
Echinococcus multilocularis phd:f box containing protein 0.0033 0.0105 0.0096
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0018 0.0011 0.0019
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0068 0.0314 0.4418
Schistosoma mansoni thyroid hormone receptor 0.002 0.0023 0.0013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0023 0.0031
Mycobacterium ulcerans acetylornithine aminotransferase 0.0073 0.0345 0.1108
Onchocerca volvulus 0.0047 0.0185 0.0374
Trypanosoma brucei DNA polymerase kappa, putative 0.0111 0.057 0.8027
Plasmodium vivax flap endonuclease 1, putative 0.0029 0.0079 0.1325
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.012 0.0567
Mycobacterium ulcerans hypothetical protein 0.0025 0.0054 0.0134
Brugia malayi hypothetical protein 0.0029 0.0081 0.0146
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0018 0.0016 0.0006
Mycobacterium tuberculosis Probable integral membrane protein 0.0019 0.0022 0.0044
Plasmodium vivax SET domain protein, putative 0.01 0.0506 1
Trypanosoma brucei DNA damage repair protein, putative 0.0025 0.0054 0.0763
Echinococcus granulosus jumonji domain containing 1A 0.0033 0.0105 0.0096
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0282 0.0273
Brugia malayi steroid hormone receptor 0.002 0.0023 0.0041
Loa Loa (eye worm) hypothetical protein 0.0033 0.0105 0.0181
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.0327 0.0317
Trichomonas vaginalis chromobox protein, putative 0.0046 0.0183 0.0402
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0224 0.0215
Brugia malayi mbt repeat family protein 0.0053 0.0224 0.0406
Echinococcus granulosus SAM and MBT domain containing protein 0.0053 0.0224 0.0215
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0018 0.0016 0.0006
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.004 0.0146 0.0136
Brugia malayi nuclear hormone receptor 0.002 0.0023 0.0041
Trypanosoma brucei DNA polymerase kappa, putative 0.0111 0.057 0.8027
Schistosoma mansoni tyrosine kinase 0.0502 0.2926 0.292
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0031 0.009 0.008
Brugia malayi Cytochrome P450 family protein 0.0037 0.0128 0.0231
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.004 0.0146 0.0136
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0023 0.0013
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0051 0.0124
Echinococcus granulosus geminin 0.055 0.3211 0.3205
Echinococcus granulosus epidermal growth factor receptor 0.0934 0.5522 0.5518
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0023 0.0031
Loa Loa (eye worm) jmjC domain-containing protein 0.0033 0.0105 0.0181
Echinococcus multilocularis ornithine aminotransferase 0.0073 0.0345 0.0336
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0282 0.3973
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.0019
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.004 0.0146 0.0254
Trypanosoma brucei unspecified product 0.0103 0.0525 0.7382
Trypanosoma brucei cytochrome P450, putative 0.0037 0.0128 0.1795
Leishmania major DNA polymerase eta, putative 0.0079 0.0379 0.5229
Echinococcus granulosus glycine receptor subunit alpha 1 0.004 0.0146 0.0136
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.004 0.0146 0.0264
Brugia malayi PAS domain containing protein 0.0103 0.0526 0.0952
Brugia malayi CXXC zinc finger family protein 0.015 0.081 0.1467
Entamoeba histolytica CAAX amino terminal protease family 0.0019 0.0022 0.0056
Schistosoma mansoni neurotransmitter gated ion channel 0.0018 0.0016 0.0006
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.005 0.0206 0.0197
Loa Loa (eye worm) hypothetical protein 0.0094 0.047 0.0842
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0018 0.0016 0.0029
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.004 0.0146 0.0136
Toxoplasma gondii Erv1 / Alr family protein 0.0068 0.0314 0.1835
Trypanosoma brucei DNA polymerase IV, putative 0.0111 0.057 0.8027
Loa Loa (eye worm) cytochrome P450 family protein 0.0059 0.0259 0.046
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0244 0.0234
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.012 0.011
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0018 0.0016 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.0111 0.057 0.8027
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0073 0.0345 0.1103
Loa Loa (eye worm) hypothetical protein 0.0034 0.0107 0.0185
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0016 0.0029
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0018 0.0011 0.0001
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0022 0.0034 0.0484
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0163 0.0359
Echinococcus multilocularis geminin 0.055 0.3211 0.3205
Loa Loa (eye worm) TK/INSR protein kinase 0.0299 0.1705 0.3081
Echinococcus granulosus aryl hydrocarbon receptor 0.0027 0.0066 0.0057
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0073 0.0345 0.1103
Mycobacterium tuberculosis Probable lipase LipD 0.0081 0.0391 0.1275
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0022 0.0034 0.0268
Brugia malayi RNA binding protein 0.0063 0.0282 0.0511
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.012 0.1686
Brugia malayi hypothetical protein 0.0087 0.043 0.0779
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0143 0.0133
Loa Loa (eye worm) hypothetical protein 0.0204 0.1132 0.2042
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.004 0.0146 0.0136
Trypanosoma brucei unspecified product 0.0055 0.0237 0.3328
Echinococcus multilocularis netrin receptor unc 5 0.003 0.0088 0.0079
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.004 0.0146 0.0136
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0042 0.0157 0.0147
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0204 0.1132 0.2466
Loa Loa (eye worm) jmjC domain-containing protein 0.0033 0.0105 0.0181
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0073 0.0345 0.0625
Trypanosoma cruzi DNA damage repair protein, putative 0.0025 0.0054 0.0763
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0022 0.0035 0.0063
Plasmodium falciparum glutathione reductase 0.0022 0.0034 0.0542
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0282 0.0273
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.01 0.0506 0.0497
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.012 0.011
Onchocerca volvulus 0.0081 0.0391 0.0828
Schistosoma mansoni hypothetical protein 0.055 0.3211 0.3205
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0027 0.0066 0.0146
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.004 0.0146 0.0254
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.004 0.0146 0.0254
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0018 0.0016 0.0006
Schistosoma mansoni jumonji/arid domain-containing protein 0.0133 0.0707 0.0698
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0081 0.0399
Echinococcus multilocularis nAChR subunit 0.004 0.0146 0.0136
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0016 0.0029
Trypanosoma cruzi DNA damage repair protein, putative 0.0025 0.0054 0.0763
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0051 0.0124
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0023 0.0041
Brugia malayi chromobox protein homolog 3 0.0043 0.0163 0.0295
Trypanosoma cruzi hypothetical protein, conserved 0.0081 0.0391 0.55
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0073 0.0345 0.0336
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.01 0.0506 0.0497
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0163 0.0359
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0027 0.0066 0.0146
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0022 0.0034 0.0484
Leishmania major hypothetical protein, conserved 0.0033 0.0105 0.1284
Mycobacterium tuberculosis Conserved protein 0.0081 0.0391 0.1275
Echinococcus granulosus death domain containing protein 0.003 0.0088 0.0079
Loa Loa (eye worm) fli-1 protein 0.0246 0.1386 0.2503
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0033 0.0105 0.0549
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.008 0.0386 0.0377
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0023 0.0031

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 2 mg kg-1 Compound was tested for oral efficacy on systemic infections caused by Staphylococcus aureus IID803 in mice. ChEMBL. 8126698
ED50 (functional) = 2 mg kg-1 Compound was tested for oral efficacy on systemic infections caused by E. coli KC-14 in mice ChEMBL. 8126698
ED50 (functional) = 2 mg kg-1 Compound was tested for oral efficacy on systemic infections caused by Staphylococcus aureus IID803 in mice. ChEMBL. 8126698
ED50 (functional) = 2 mg kg-1 Compound was tested for oral efficacy on systemic infections caused by E. coli KC-14 in mice ChEMBL. 8126698
MIC (functional) = 0.025 g ml-1 In vitro minimum inhibitory concentration against gram-positive Sa (F), Staphylococcus aureus FDA 209P JC-1. ChEMBL. 8126698
MIC (functional) = 0.025 g ml-1 In vitro minimum inhibitory concentration against gram-positive Sa (I), Staphylococcus aureus IID803. ChEMBL. 8126698
MIC (functional) = 0.1 g ml-1 In vitro minimum inhibitory concentration against gram-positive Se, Staphylococcus epidermidis IAM 1296. ChEMBL. 8126698
MIC (functional) = 0.1 g ml-1 In vitro minimum inhibitory concentration against gram-negative Ec(N), Escherichia coli NIHJ JC-2. ChEMBL. 8126698
MIC (functional) = 0.1 g ml-1 Compound was tested for in vitro antibacterial activity (minimum inhibition concentration) against gram-negative Ec(K), Escherichia coli KC-14. ChEMBL. 8126698
MIC (functional) = 0.1 g ml-1 In vitro minimum inhibitory concentration against gram-negative Ec(N), Escherichia coli NIHJ JC-2. ChEMBL. 8126698
MIC (functional) = 0.1 g ml-1 Compound was tested for in vitro antibacterial activity (minimum inhibition concentration) against gram-negative Ec(K), Escherichia coli KC-14. ChEMBL. 8126698
MIC (functional) = 0.2 g ml-1 In vitro minimum inhibitory concentration against gram-positive Ef Enterococcus faecalis IID 682. ChEMBL. 8126698
MIC (functional) = 0.2 g ml-1 In vitro minimum inhibitory concentration against gram-negative Kp, Klebsiella pneumoniae B54. ChEMBL. 8126698
MIC (functional) = 0.39 g ml-1 Minimum inhibitory concentration against gram-positive MI, Micrococcus luteus ATCC 9341. ChEMBL. 8126698
MIC (functional) = 1.56 g ml-1 Compound was tested for in vitro antibacterial activity (minimum inhibition concentration) against gram-negative Pa(E), Pseudomonas aeruginosa E-2. ChEMBL. 8126698
MIC (functional) = 3.13 g ml-1 In vitro minimum inhibitory concentration against gram-negative Pa(I), Pseudomonas aeruginosa IFO 3445. ChEMBL. 8126698
MIC50 (functional) = 0.78 g ml-1 Compound was tested for the in vitro antibacterial activity (minimum inhibitory concentration) against 50% of clinical isolates of methicillin-resistant Staphylococcus aureus (MIC range) ChEMBL. 8126698
MIC90 (functional) = 1.56 g ml-1 Compound was tested for the in vitro antibacterial activity (minimum inhibitory concentration) against 90% of clinical isolates of methicillin-resistant Staphylococcus aureus (MIC range) ChEMBL. 8126698

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.