Detailed information for compound 290806

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 415.695 | Formula: C28H49NO
  • H donors: 2 H acceptors: 1 LogP: 6.62 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(CCC[C@H](C1CCN[C@@]2([C@]1(C)CCC1=C2CCC2[C@]1(C)CC[C@@H](C2)O)C)C)C
  • InChi: 1S/C28H49NO/c1-19(2)8-7-9-20(3)23-14-17-29-28(6)25-11-10-21-18-22(30)12-15-26(21,4)24(25)13-16-27(23,28)5/h19-23,29-30H,7-18H2,1-6H3/t20-,21?,22+,23?,26+,27-,28+/m1/s1
  • InChiKey: FXYWZSZQPOXFIV-HVJFXDQJSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus nuclear receptor nhr 48 0.0015 0.0022 0.004
Brugia malayi MH1 domain containing protein 0.0019 0.0037 0.0037
Trichomonas vaginalis glucosylceramidase, putative 0.0079 0.0242 0.0242
Leishmania major hypothetical protein, conserved 0.0067 0.0202 0.0185
Brugia malayi beta-lactamase 0.0067 0.0202 0.0202
Trichomonas vaginalis phosphofructokinase, putative 0.0046 0.013 0.0129
Loa Loa (eye worm) hypothetical protein 0.002 0.004 0.004
Trichomonas vaginalis phosphofructokinase, putative 0.0013 0.0013 0.0013
Echinococcus granulosus metabotropic glutamate receptor 2 0.0015 0.0022 0.0039
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0021 0.0042 0.0076
Loa Loa (eye worm) hypothetical protein 0.0042 0.0114 0.0114
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0023 0.005 0.005
Mycobacterium ulcerans beta-lactamase 0.0067 0.0202 0.0197
Trichomonas vaginalis phosphofructokinase, putative 0.0013 0.0013 0.0013
Schistosoma mansoni nuclear receptor 0.0015 0.0022 0.004
Loa Loa (eye worm) hypothetical protein 0.0017 0.0028 0.0028
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0015 0.0022 0.0022
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0.0024 0.0042
Loa Loa (eye worm) hypothetical protein 0.0027 0.0063 0.0063
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.008 0.008
Schistosoma mansoni Smad4 0.0019 0.0037 0.0066
Mycobacterium ulcerans glutaminase 0.0132 0.0424 0.0419
Entamoeba histolytica trans-2,3-enoyl-CoA reductase, putative 0.1629 0.5572 0.5572
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0007
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0017 0.0028 0.005
Echinococcus multilocularis tar DNA binding protein 0.0113 0.036 0.0646
Trichomonas vaginalis glucosylceramidase, putative 0.0114 0.0363 0.0363
Loa Loa (eye worm) TK/EGFR protein kinase 0.0149 0.0482 0.0482
Loa Loa (eye worm) hypothetical protein 0.0017 0.0028 0.0028
Brugia malayi PHD-finger family protein 0.0014 0.0018 0.0018
Trichomonas vaginalis CMGC family protein kinase 0.0029 0.0071 0.0071
Schistosoma mansoni nuclear receptor nhr-48 0.0015 0.0022 0.004
Loa Loa (eye worm) hypothetical protein 0.0023 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0033 0.0084 0.0084
Echinococcus multilocularis lamin dm0 0.0012 0.0011 0.002
Brugia malayi nuclear hormone receptor family member odr-7 0.0015 0.0022 0.0022
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.1629 0.5572 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0005
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0021 0.0042 0.0076
Echinococcus granulosus epidermal growth factor receptor 0.008 0.0245 0.044
Loa Loa (eye worm) hypothetical protein 0.0026 0.0059 0.0059
Schistosoma mansoni hypothetical protein 0.0174 0.057 0.1023
Echinococcus granulosus mothers against decapentaplegic 5 0.0019 0.0037 0.0066
Loa Loa (eye worm) hypothetical protein 0.0027 0.0063 0.0063
Brugia malayi steroid hormone receptor 0.0032 0.008 0.008
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0021 0.0042 0.0076
Echinococcus granulosus muscleblind protein 0.007 0.0211 0.0378
Brugia malayi Pax transcription factor protein 2 0.0107 0.0337 0.0337
Loa Loa (eye worm) hypothetical protein 0.002 0.004 0.004
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0014 0.0017 0.0012
Schistosoma mansoni 6-phosphofructokinase 0.0046 0.013 0.0233
Loa Loa (eye worm) hypothetical protein 0.0015 0.0022 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0032 0.008 0.008
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0009 0.0002 0.0002
Trichomonas vaginalis penicillin-binding protein, putative 0.0067 0.0202 0.0201
Trichomonas vaginalis D-aminoacylase, putative 0.0067 0.0202 0.0201
Schistosoma mansoni synaptic glycoprotein sc2 related 0.1629 0.5572 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.008 0.0144
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0025 0.0058 0.0054
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0008
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.008 0.0246 0.0441
Schistosoma mansoni hypothetical protein 0.0112 0.0354 0.0635
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0063 0.0063
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0034 0.0088 0.0083
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0008
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0023 0.005 0.0089
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0025 0.0055 0.0051
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0032 0.008 0.008
Echinococcus multilocularis glycine receptor subunit beta 0.002 0.004 0.0072
Loa Loa (eye worm) MH2 domain-containing protein 0.0019 0.0037 0.0037
Schistosoma mansoni lamin 0.0012 0.0011 0.002
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.002 0.004 0.004
Schistosoma mansoni tyrosine kinase 0.008 0.0245 0.044
Loa Loa (eye worm) hypothetical protein 0.0018 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0032 0.008 0.008
Leishmania major phosphatidylinositol 3-kinase, putative 0.0015 0.0024 0.0007
Brugia malayi hypothetical protein 0.0009 0.0002 0.0002
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0033 0.0033
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.002 0.004 0.004
Loa Loa (eye worm) mbt repeat family protein 0.0023 0.0048 0.0048
Echinococcus granulosus nAChR subunit 0.002 0.004 0.0072
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0032 0.008 0.0144
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0032 0.008 0.0144
Echinococcus granulosus ecdysone induced protein 78C 0.0032 0.008 0.0144
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0067 0.0202 0.0202
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0043 0.0043
Schistosoma mansoni ap endonuclease 0.0037 0.0097 0.0173
Loa Loa (eye worm) glutaminase 2 0.0132 0.0424 0.0424
Brugia malayi ecdysteroid receptor 0.0032 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.007 0.0211 0.0211
Echinococcus multilocularis beta LACTamase domain containing family member 0.0067 0.0202 0.0362
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0024 0.0024
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0029 0.0071 0.0068
Onchocerca volvulus Bile acid receptor homolog 0.0032 0.008 0.0144
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0032 0.008 0.0144
Echinococcus multilocularis thyroid hormone receptor alpha 0.0032 0.008 0.0144
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0032 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0109 0.0344 0.0344
Brugia malayi TAR-binding protein 0.0113 0.036 0.036
Echinococcus multilocularis survival motor neuron protein 1 0.0547 0.1852 0.3323
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.002 0.004 0.0072
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0013 0.0013 0.0013
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0174 0.057 0.0566
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0029 0.0071 0.0054
Schistosoma mansoni tyrosine kinase 0.0079 0.0242 0.0434
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.002 0.004 0.0072
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0032 0.008 0.0144
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0112 0.0354 0.0354
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0021 0.0042 0.027
Toxoplasma gondii 6-phosphofructokinase 0.0013 0.0013 0.001
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0021 0.0043 0.004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0032 0.008 0.008
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0083 0.0254 0.0254
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0015 0.0024 0.0023
Echinococcus granulosus epidermal growth factor receptor 0.0149 0.0482 0.0864
Toxoplasma gondii isocitrate dehydrogenase 0.0021 0.0042 0.0039
Echinococcus granulosus expressed protein 0.0016 0.0026 0.0047
Onchocerca volvulus 0.0011 0.0008 0.0014
Trichomonas vaginalis glutaminase, putative 0.0132 0.0424 0.0424
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0075 0.0228 0.0228
Entamoeba histolytica phosphofructokinase, putative 0.0046 0.013 0.0129
Echinococcus multilocularis dnaJ subfamily B 0.0174 0.057 0.1023
Onchocerca volvulus Peroxidasin homolog 0.0027 0.0063 0.0114
Schistosoma mansoni metabotropic glutamate receptor 0.0015 0.0022 0.0039
Loa Loa (eye worm) hypothetical protein 0.0022 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0002
Loa Loa (eye worm) CXXC zinc finger family protein 0.0037 0.0097 0.0097
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0029 0.0071 0.0068
Loa Loa (eye worm) hypothetical protein 0.0019 0.0036 0.0036
Echinococcus granulosus insulin receptor 0.0048 0.0134 0.024
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0021 0.0042 0.0076
Trichomonas vaginalis glucosylceramidase, putative 0.0075 0.0228 0.0228
Echinococcus multilocularis musashi 0.0012 0.0011 0.002
Entamoeba histolytica acyl-CoA synthetase, putative 0.0014 0.0017 0.0017
Echinococcus granulosus geminin 0.0575 0.1947 0.3494
Echinococcus granulosus zinc finger protein 0.0011 0.0009 0.0016
Onchocerca volvulus 0.0012 0.0011 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0024 0.0023
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0025 0.0058 0.0054
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0023 0.0048 0.0086
Entamoeba histolytica hypothetical protein 0.005 0.0143 0.0142
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0017 0.0028 0.0051
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0015 0.0022 0.0039
Echinococcus multilocularis 0.0046 0.0128 0.0231
Echinococcus multilocularis neuropeptide s receptor 0.0437 0.1474 0.2645
Echinococcus granulosus microtubule associated protein 2 0.1602 0.5479 0.9831
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0022 0.0022
Trypanosoma cruzi PAB1-binding protein , putative 0.0033 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0015 0.0022 0.0022
Leishmania major hypothetical protein, conserved 0.0033 0.0085 0.0068
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0114 0.0363 0.0363
Trichomonas vaginalis D-aminoacylase, putative 0.0067 0.0202 0.0201
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.008 0.0246 0.0441
Trichomonas vaginalis phosphofructokinase, putative 0.0013 0.0013 0.0013
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0017 0.0028 0.0051
Trichomonas vaginalis phosphofructokinase, putative 0.0013 0.0013 0.0013
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0015 0.0024 0.002
Brugia malayi latrophilin 2 splice variant baaae 0.009 0.0281 0.0281
Brugia malayi Cation transporter family protein 0.002 0.004 0.004
Brugia malayi MH2 domain containing protein 0.0019 0.0037 0.0037
Brugia malayi nuclear hormone receptor 0.0015 0.0022 0.0022
Onchocerca volvulus 0.0009 0.0002 0.0004
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.002 0.004 0.004
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.002 0.004 0.0072
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.008 0.0144
Schistosoma mansoni neurotransmitter gated ion channel 0.0009 0.0002 0.0004
Brugia malayi photoreceptor-specific nuclear receptor 0.0032 0.008 0.008
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0015 0.0024 0.002
Onchocerca volvulus 0.0009 0.0002 0.0004
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.2917 1 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0067 0.0202 0.1372
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0032 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0008
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.002 0.004 0.0072
Loa Loa (eye worm) blistered cuticle protein 3 0.0027 0.0063 0.0063
Plasmodium vivax 6-phosphofructokinase, putative 0.0013 0.0013 0.0015
Echinococcus granulosus histone acetyltransferase MYST2 0.0026 0.0059 0.0106
Schistosoma mansoni tyrosine kinase 0.0079 0.0242 0.0434
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0011
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.1629 0.5572 0.5571
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0032 0.008 0.0144
Loa Loa (eye worm) glutaminase 0.0132 0.0424 0.0424
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0114 0.0363 0.0363
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0004 0.0006
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0028 0.0028
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.1629 0.5572 1
Echinococcus granulosus mitogen activated protein kinase 0.0029 0.0071 0.0128
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0042 0.0114 0.0205
Schistosoma mansoni nAChR subunit 0.002 0.004 0.0072
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0024 0.0024
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.002 0.004 0.0072
Toxoplasma gondii ABC1 family protein 0.0067 0.0202 0.0198
Trichomonas vaginalis CMGC family protein kinase 0.0029 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0017 0.0028 0.0028
Plasmodium vivax ataxin-2 like protein, putative 0.0033 0.0085 0.0144
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.2917 1 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0063 0.0063
Onchocerca volvulus Peroxidase homolog 0.0027 0.0063 0.0114
Mycobacterium tuberculosis Probable lipase LipD 0.0067 0.0202 0.1372
Brugia malayi Furin-like cysteine rich region family protein 0.0149 0.0482 0.0482
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.01 0.0315 0.0315
Echinococcus multilocularis nAChR subunit 0.002 0.004 0.0072
Brugia malayi Metabotropic glutamate receptor precursor. 0.0018 0.0032 0.0032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0024 0.0023
Entamoeba histolytica acyl-coA synthetase, putative 0.0014 0.0017 0.0017
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0017 0.0028 0.0051
Brugia malayi intermediate filament protein 0.0012 0.0011 0.0011
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.005 0.0143 0.0256
Schistosoma mansoni hypothetical protein 0.0575 0.1947 0.3494
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0009 0.0002 0.0002
Mycobacterium tuberculosis Probable esterase LipL 0.0067 0.0202 0.1372
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0043 0.0043
Loa Loa (eye worm) glutamate receptor 0.0018 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0014 0.0017 0.0017
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0058 0.0169 0.0304
Brugia malayi Intermediate filament tail domain containing protein 0.0012 0.0011 0.0011
Mycobacterium ulcerans lipase LipD 0.0067 0.0202 0.0197
Onchocerca volvulus 0.002 0.004 0.0072
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0097 0.0096
Loa Loa (eye worm) hypothetical protein 0.0032 0.008 0.008
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0015 0.0024 0.0023
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0063 0.0063
Echinococcus multilocularis glycine receptor subunit beta 0.002 0.004 0.0072
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0015 0.0022 0.004
Brugia malayi nuclear receptor NHR-67 0.0015 0.0022 0.0022
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0034 0.0088 0.0157
Trypanosoma brucei protein kinase, putative 0.0029 0.0071 0.0068
Loa Loa (eye worm) hypothetical protein 0.0015 0.0022 0.0022
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0067 0.0202 0.0362
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0014 0.0017 0.0012
Loa Loa (eye worm) hypothetical protein 0.0067 0.0202 0.0202
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0014 0.0017 0.0012
Echinococcus granulosus TGF beta signal transducer SmadC 0.0019 0.0037 0.0066
Echinococcus multilocularis lamin 0.0012 0.0011 0.002
Brugia malayi nuclear hormone receptor 0.0032 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.002 0.004 0.004
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0029 0.0071 0.0071
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0021 0.0042 0.0067
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.1629 0.5572 0.5572
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.002 0.004 0.0073
Entamoeba histolytica hypothetical protein 0.0011 0.0008 0.0008
Echinococcus granulosus polycomb protein SCMH1 0.0023 0.0048 0.0086
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0011
Schistosoma mansoni mixed-lineage leukemia protein mll 0.001 0.0004 0.0006
Trichomonas vaginalis glucosylceramidase, putative 0.0114 0.0363 0.0363
Mycobacterium leprae PROBABLE NAPHTHOATE SYNTHASE MENB (DIHYDROXYNAPHTHOIC ACID SYNTHETASE) (DHNA SYNTHETASE) 0.0232 0.0768 1
Schistosoma mansoni hypothetical protein 0.0042 0.0114 0.0205
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.002 0.004 0.0072
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0011 0.0008 0.0008
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0009 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0015 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0014 0.0017 0.0017
Schistosoma mansoni nAChR subunit 0.0009 0.0002 0.0004
Schistosoma mansoni tar DNA-binding protein 0.0113 0.036 0.0646
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0002
Entamoeba histolytica hypothetical protein 0.005 0.0143 0.0142
Brugia malayi hypothetical protein 0.005 0.0143 0.0143
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0063 0.0063
Schistosoma mansoni nAChR subunit 0.002 0.004 0.0072
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0011 0.0008 0.0008
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0017 0.0012
Loa Loa (eye worm) hypothetical protein 0.0067 0.0202 0.0202
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0015 0.0022 0.0039
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0042 0.0114 0.0205
Loa Loa (eye worm) MBCTL1 0.0026 0.0059 0.0059
Onchocerca volvulus 0.0015 0.0022 0.004
Loa Loa (eye worm) hypothetical protein 0.002 0.004 0.004
Onchocerca volvulus 0.002 0.004 0.0072
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0024 0.0023
Plasmodium falciparum ataxin-2 like protein, putative 0.0033 0.0085 0.0144
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0023 0.0048 0.0086
Loa Loa (eye worm) hypothetical protein 0.0015 0.0022 0.0022
Echinococcus granulosus neuropeptide s receptor 0.0437 0.1474 0.2645
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.003 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0099 0.0312 0.0312
Schistosoma mansoni thyroid hormone receptor 0.0032 0.008 0.0144
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0024 0.0023
Brugia malayi 6-phosphofructokinase 0.0046 0.013 0.013
Schistosoma mansoni bromodomain containing protein 0.0032 0.0079 0.0142
Echinococcus multilocularis isocitrate dehydrogenase 0.0021 0.0042 0.0076
Echinococcus multilocularis zinc finger protein 0.0011 0.0009 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0024 0.0023
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0015 0.0022 0.004
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0.0024 0.0042
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.002 0.004 0.0072
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0032 0.008 0.0144
Trypanosoma cruzi cysteine peptidase, putative 0.0025 0.0058 0.0057
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0097 0.0091
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0002
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0009 0.0002 0.0004
Trichomonas vaginalis ferritin, putative 0.0016 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.002 0.004 0.004
Schistosoma mansoni metabotropic glutamate receptor 0.0009 0 0.0001
Trypanosoma cruzi cruzipain precursor, putative 0.0025 0.0058 0.0057
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0031 0.0077 0.006
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0063 0.0063
Onchocerca volvulus 0.0067 0.0202 0.0362
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0016 0.0026 0.0124
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0015 0.0022 0.004
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.008 0.008
Echinococcus multilocularis mitogen activated protein kinase 3 0.0029 0.0071 0.0128
Trypanosoma cruzi target of rapamycin kinase 3 0.0015 0.0024 0.0023
Schistosoma mansoni nuclear receptor 0.0015 0.0022 0.004
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0032 0.008 0.008
Brugia malayi MH1 domain containing protein 0.0019 0.0037 0.0037
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.002 0.004 0.0072
Schistosoma mansoni cpg binding protein 0.004 0.0107 0.0192
Loa Loa (eye worm) hypothetical protein 0.0067 0.0202 0.0202
Echinococcus multilocularis polycomb protein SCMH1 0.0023 0.0048 0.0086
Echinococcus granulosus intermediate filament protein 0.0012 0.0011 0.002
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0032 0.008 0.0144
Loa Loa (eye worm) hypothetical protein 0.0033 0.0085 0.0085
Schistosoma mansoni tar DNA-binding protein 0.0113 0.036 0.0646
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0002
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0021 0.0042 0.0039
Schistosoma mansoni tar DNA-binding protein 0.0113 0.036 0.0646
Entamoeba histolytica phosphofructokinase, putative 0.0046 0.013 0.0129
Onchocerca volvulus Glucosylceramidase homolog 0.0075 0.0228 0.0409
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.1629 0.5572 0.5572
Brugia malayi MAP kinase sur-1 0.0029 0.0071 0.0071
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.002 0.004 0.004
Echinococcus granulosus mitogen activated protein kinase 3 0.0029 0.0071 0.0128
Brugia malayi MH2 domain containing protein 0.0019 0.0037 0.0037
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.1629 0.5572 0.5572
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.008 0.0144
Schistosoma mansoni ferritin 0.0016 0.0026 0.0047
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0032 0.008 0.0144
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0016 0.0024 0.0023
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0017 0.0012
Loa Loa (eye worm) LGC-31 protein 0.002 0.004 0.004
Echinococcus granulosus SAM and MBT domain containing protein 0.0023 0.0048 0.0086
Loa Loa (eye worm) hypothetical protein 0.1629 0.5572 0.5572
Entamoeba histolytica steroid 5-alpha reductase, putative 0.2917 1 1
Loa Loa (eye worm) RNA binding protein 0.0113 0.036 0.036
Trypanosoma brucei PAB1-binding protein , putative 0.0033 0.0085 0.0082
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0008
Schistosoma mansoni apoferritin-2 0.0016 0.0026 0.0047
Schistosoma mansoni hypothetical protein 0.0145 0.0469 0.0841
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0025 0.0058 0.0054
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.2917 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0075 0.0228 0.0228
Schistosoma mansoni zinc finger protein 0.0015 0.0022 0.004
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.008 0.0144
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0109 0.0344 0.0344
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0031 0.0077 0.0077
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0097 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0019 0.0037 0.0066
Echinococcus multilocularis mixed lineage leukemia protein mll 0.001 0.0004 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0024 0.0023
Onchocerca volvulus 0.0027 0.0063 0.0114
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1144 0.3905 0.7008
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0009 0.0002 0.0002
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0015 0.0024 0.0007
Onchocerca volvulus 0.0015 0.0022 0.004
Trichomonas vaginalis glucosylceramidase, putative 0.0079 0.0242 0.0242
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0031 0.0077 0.0077
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0024 0.0023
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0031 0.0077 0.0076
Trypanosoma cruzi hypothetical protein, conserved 0.0067 0.0202 0.0201
Loa Loa (eye worm) Smad1 0.0019 0.0037 0.0037
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.002 0.004 0.004
Schistosoma mansoni intermediate filament proteins 0.0012 0.0011 0.002
Brugia malayi hypothetical protein 0.0022 0.0044 0.0044
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.2917 1 1
Trichomonas vaginalis D-aminoacylase, putative 0.0067 0.0202 0.0201
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0029 0.0071 0.0071
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0025 0.0058 0.0054
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0024 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.008 0.008
Giardia lamblia GTOR 0.0015 0.0024 0.0018
Mycobacterium ulcerans hypothetical protein 0.2917 1 1
Onchocerca volvulus 0.0032 0.008 0.0144
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0008
Brugia malayi hypothetical protein 0.0547 0.1852 0.1852
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0019 0.0037 0.0066
Schistosoma mansoni acetylcholine receptor subunit beta 0.0009 0.0002 0.0004
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0029 0.0071 0.0071
Schistosoma mansoni cpg binding protein 0.0037 0.0097 0.0174
Loa Loa (eye worm) nuclear factor I 0.0011 0.0007 0.0007
Trichomonas vaginalis glucosylceramidase, putative 0.0114 0.0363 0.0363
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0015 0.0022 0.004
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.008 0.0246 0.0246
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0017 0.0028 0.005
Brugia malayi Steroid receptor seven-up type 2 0.0032 0.008 0.008
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.2917 1 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.007 0.0211 0.0211
Loa Loa (eye worm) hypothetical protein 0.0027 0.0063 0.0063
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0174 0.057 0.057
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0015 0.0024 0.0007
Brugia malayi hypothetical protein 0.0015 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0015 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0004
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.002 0.004 0.0072
Plasmodium vivax polyprenol reductase, putative 0.1629 0.5572 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0032 0.008 0.0144
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0024 0.0023
Loa Loa (eye worm) latrophilin receptor protein 2 0.0042 0.0114 0.0114
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0013 0.0014 0.0025
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0009 0.0002 0.0002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0025 0.0058 0.0054
Brugia malayi hypothetical protein 0.0015 0.0022 0.0022
Brugia malayi phosphofructokinase 0.0046 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0027 0.0063 0.0063
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0009 0.0002 0.0002
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.002 0.004 0.0072
Brugia malayi hypothetical protein 0.0009 0.0002 0.0002
Onchocerca volvulus Chorion peroxidase homolog 0.0027 0.0063 0.0114
Mycobacterium leprae conserved hypothetical protein 0.0067 0.0202 0.2458
Schistosoma mansoni transcription factor LCR-F1 0.005 0.0143 0.0256
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0008
Schistosoma mansoni sex comb on midleg homolog 0.0023 0.0048 0.0086
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0048 0.0134 0.024
Onchocerca volvulus Putative nachr subunit 0.002 0.004 0.0072
Brugia malayi Latrophilin receptor protein 2 0.0042 0.0114 0.0114
Echinococcus multilocularis mitogen activated protein kinase 0.0029 0.0071 0.0128
Loa Loa (eye worm) hypothetical protein 0.0022 0.0046 0.0046
Brugia malayi Peroxidasin 0.0027 0.0063 0.0063
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0025 0.0058 0.0054
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0002
Brugia malayi excitatory GABA receptor EXP-1A 0.002 0.004 0.004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0024 0.0023
Trypanosoma cruzi cysteine peptidase, putative 0.0025 0.0058 0.0057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0024 0.0023
Onchocerca volvulus 0.0067 0.0202 0.0362
Echinococcus granulosus peroxidasin 0.0027 0.0063 0.0114
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0002
Schistosoma mansoni coup transcription factor 0.0032 0.008 0.0144
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0022 0.004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0024 0.0023
Brugia malayi hypothetical protein 0.0009 0.0002 0.0002
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0097 0.0097
Echinococcus granulosus beta LACTamase domain containing family member 0.0067 0.0202 0.0362
Brugia malayi Isocitrate dehydrogenase 0.0021 0.0042 0.0042
Schistosoma mansoni hypothetical protein 0.0575 0.1947 0.3494
Brugia malayi conserved hypotetical protein 0.0015 0.0022 0.0022
Schistosoma mansoni nAChR subunit 0.002 0.004 0.0072
Schistosoma mansoni peroxidasin 0.0027 0.0063 0.0114
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0029 0.0071 0.0071
Loa Loa (eye worm) MH1 domain-containing protein 0.0019 0.0037 0.0037
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.008 0.0144
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0097 0.0093
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0132 0.0425 0.0425
Echinococcus multilocularis ferritin 0.0016 0.0026 0.0047
Mycobacterium ulcerans hypothetical protein 0.0056 0.0162 0.0157
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.0022 0.004
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0097 0.008
Loa Loa (eye worm) hypothetical protein 0.0017 0.0028 0.0028
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0113 0.036 0.036
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0097 0.0096
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0022 0.0022
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0014 0.0017 0.0012
Schistosoma mansoni hypothetical protein 0.0042 0.0114 0.0205
Loa Loa (eye worm) hypothetical protein 0.0032 0.008 0.008
Echinococcus granulosus transcription factor Dp 1 0.0018 0.0032 0.0057
Schistosoma mansoni zinc finger protein 0.0011 0.0009 0.0016
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0024 0.0024
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0067 0.0202 0.0362
Loa Loa (eye worm) hypothetical protein 0.009 0.0281 0.0281
Trichomonas vaginalis phosphofructokinase, putative 0.0013 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0002
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0014 0.0017 0.0031
Onchocerca volvulus 0.0009 0.0002 0.0004
Onchocerca volvulus 0.0023 0.0048 0.0086
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0013 0.0013 1
Loa Loa (eye worm) pax transcription factor protein 2 0.0107 0.0337 0.0337
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0021 0.0042 0.0076
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.1629 0.5572 0.5571
Echinococcus multilocularis glycine receptor subunit alpha 1 0.002 0.004 0.0072
Schistosoma mansoni tyrosine kinase 0.0079 0.0242 0.0434
Entamoeba histolytica hypothetical protein 0.0021 0.0043 0.0043
Schistosoma mansoni survival motor neuron protein 0.0112 0.0354 0.0635
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0063 0.0063
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0046 0.013 0.15
Mycobacterium ulcerans naphthoate synthase 0.0232 0.0768 0.0763
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0024 0.0023
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0002
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0029 0.0071 0.0054
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0021 0.0042 0.0076
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0032 0.008 0.0144
Loa Loa (eye worm) hypothetical protein 0.0027 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0032 0.008 0.008
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0013 0.0013 0.0015
Echinococcus multilocularis muscleblind protein 0.007 0.0211 0.0378
Loa Loa (eye worm) hypothetical protein 0.0015 0.0022 0.0022
Loa Loa (eye worm) transcription factor SMAD2 0.0284 0.0948 0.0948
Loa Loa (eye worm) hypothetical protein 0.0027 0.0063 0.0063
Toxoplasma gondii hypothetical protein 0.0028 0.0067 0.0063
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0002
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0174 0.057 0.057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0024 0.0023
Schistosoma mansoni myelin transcription factor 1 myt1 0.0026 0.0059 0.0106
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0015 0.0024 0.002
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.002 0.004 0.0072
Echinococcus multilocularis peroxidasin 0.0027 0.0063 0.0114
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0024 0.0023
Brugia malayi mbt repeat family protein 0.0023 0.0048 0.0048
Loa Loa (eye worm) 6-phosphofructokinase 0.0046 0.013 0.013
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.004 0.004
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0021 0.0042 0.0039
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0015 0.0022 0.004
Loa Loa (eye worm) hypothetical protein 0.0015 0.0022 0.0022
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0015 0.0024 0.0023
Echinococcus multilocularis transcription factor Dp 1 0.0018 0.0032 0.0057
Loa Loa (eye worm) acetylcholine receptor protein 0.0009 0.0002 0.0002
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0012 0.0011 0.0011
Schistosoma mansoni ferritin 0.0016 0.0026 0.0047
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0002
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.008 0.0245 0.044
Schistosoma mansoni ferritin light chain 0.0016 0.0026 0.0047
Echinococcus multilocularis glycine receptor subunit alpha 1 0.002 0.004 0.0072
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.004 0.004
Echinococcus granulosus Smad4 0.0019 0.0037 0.0066
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.008 0.0246 0.0441
Brugia malayi nuclear hormone receptor family member nhr-6 0.0015 0.0022 0.0022
Schistosoma mansoni nAChR subunit 0.002 0.004 0.0072
Loa Loa (eye worm) hypothetical protein 0.0015 0.0022 0.0022
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0031 0.0077 0.0073
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.002 0.004 0.0072
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0023 0.005 0.0089
Entamoeba histolytica hypothetical protein 0.1629 0.5572 0.5572
Treponema pallidum bacterioferrin (TpF1) 0.0016 0.0026 0.112
Brugia malayi hypothetical protein 0.0017 0.0028 0.0028
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.2917 1 1
Brugia malayi hypothetical protein 0.0271 0.0903 0.0903
Leishmania major cathepsin L-like protease 0.0025 0.0058 0.0041
Leishmania major cathepsin L-like protease 0.0025 0.0058 0.0041
Toxoplasma gondii exonuclease III APE 0.0037 0.0097 0.0093
Schistosoma mansoni ferritin 0.0016 0.0026 0.0047
Toxoplasma gondii FATC domain-containing protein 0.0021 0.0043 0.004
Echinococcus granulosus glycine receptor subunit beta 0.002 0.004 0.0072
Schistosoma mansoni tyrosine kinase 0.008 0.0245 0.044
Loa Loa (eye worm) hypothetical protein 0.002 0.004 0.004
Echinococcus multilocularis cpg binding protein 0.004 0.0107 0.0192
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0032 0.008 0.008
Mycobacterium ulcerans bacterioferritin BfrB 0.0016 0.0026 0.0021
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0015 0.0022 0.004
Toxoplasma gondii LsmAD domain-containing protein 0.0033 0.0085 0.0082
Echinococcus multilocularis expressed protein 0.0016 0.0026 0.0047
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0075 0.0228 0.0409
Trypanosoma cruzi major cysteine proteinase, putative 0.002 0.0039 0.0039
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0011 0.0008 0.0014
Schistosoma mansoni peroxidasin 0.0027 0.0063 0.0114
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0032 0.008 0.008
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0015 0.0024 0.002
Schistosoma mansoni smad 0.0019 0.0037 0.0066
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0009 0.0002 0.0002
Trichomonas vaginalis glucosylceramidase, putative 0.0075 0.0228 0.0228
Schistosoma mansoni tyrosine kinase 0.0048 0.0134 0.024
Loa Loa (eye worm) hypothetical protein 0.002 0.004 0.004
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0032 0.008 0.0144
Loa Loa (eye worm) hypothetical protein 0.002 0.004 0.004
Entamoeba histolytica 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein 0.1629 0.5572 0.5572
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.002 0.004 0.0072
Loa Loa (eye worm) intermediate filament protein 0.0012 0.0011 0.0011
Schistosoma mansoni nAChR subunit 0.002 0.004 0.0072
Trichomonas vaginalis glucosylceramidase, putative 0.0114 0.0363 0.0363
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0011 0.002
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0008
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0021 0.0042 0.0042
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.008 0.0246 0.0441
Onchocerca volvulus 0.0012 0.0011 0.002
Loa Loa (eye worm) hypothetical protein 0.0027 0.0063 0.0063
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0013 0.0013 0.0013
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0034 0.0088 0.0584
Schistosoma mansoni ferritin light chain 0.0016 0.0026 0.0047
Schistosoma mansoni ferritin 0.0016 0.0026 0.0047
Brugia malayi Protein kinase domain containing protein 0.0048 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.002 0.004 0.004
Plasmodium falciparum 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.1629 0.5572 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0024 0.0023
Mycobacterium tuberculosis Conserved protein 0.0067 0.0202 0.1372
Schistosoma mansoni synaptic glycoprotein sc2 related 0.1629 0.5572 1
Onchocerca volvulus 0.002 0.004 0.0072
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0024 0.0023
Loa Loa (eye worm) hypothetical protein 0.002 0.004 0.004
Echinococcus granulosus mixed lineage leukemia protein mll 0.001 0.0004 0.0006
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0046 0.013 1
Brugia malayi F/Y-rich N-terminus family protein 0.0013 0.0014 0.0014
Brugia malayi tailless protein 0.0015 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0005
Onchocerca volvulus 0.002 0.004 0.0072
Brugia malayi nuclear receptor RXR 0.0017 0.0028 0.0028
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0009 0.0002 0.0002
Onchocerca volvulus 0.0114 0.0362 0.065
Echinococcus granulosus glycine receptor subunit alpha 1 0.002 0.004 0.0072
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0024 0.0023
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0015 0.0024 0.0042
Loa Loa (eye worm) hypothetical protein 0.002 0.004 0.004
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0021 0.0042 0.0042
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0017 0.0095
Mycobacterium ulcerans bacterioferritin BfrA 0.0016 0.0026 0.0021
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.002 0.004 0.004
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0013 0.0014 0.0025
Leishmania major mitochondrial DNA polymerase beta 0.0174 0.057 0.0554
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.0022 0.004
Echinococcus granulosus GPCR family 2 0.0042 0.0114 0.0205
Onchocerca volvulus 0.002 0.004 0.0072
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0097 0.7157
Schistosoma mansoni sex comb on midleg homolog 0.0023 0.0048 0.0086
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0016 0.0026 0.0026
Loa Loa (eye worm) nuclear receptor NHR-67 0.0015 0.0022 0.0022
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0029 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0015 0.0022 0.0022
Loa Loa (eye worm) nuclear hormone receptor 0.0015 0.0022 0.0022
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0013 0.0013 0.0015
Echinococcus multilocularis FTZ F1 alpha 0.0032 0.008 0.0144
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0015 0.0024 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0024 0.0023
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0022 0.004
Loa Loa (eye worm) hypothetical protein 0.0015 0.0022 0.0022
Echinococcus granulosus smad 0.0019 0.0037 0.0066
Brugia malayi nuclear receptor RXR 0.0015 0.0022 0.0022
Toxoplasma gondii isocitrate dehydrogenase 0.0021 0.0042 0.0039
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0034 0.0088 0.0157
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.0024 0.0042
Schistosoma mansoni hypothetical protein 0.0042 0.0114 0.0205
Echinococcus granulosus glycine receptor subunit alpha 1 0.002 0.004 0.0072
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0015 0.0022 0.004
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0031 0.0077 0.0137
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0097 0.0173
Echinococcus multilocularis neuropeptide receptor A26 0.0437 0.1474 0.2645
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.004 0.004
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0011 0.0008 0.0014
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.001 0.0005 0.0013
Echinococcus multilocularis 6 phosphofructokinase 0.0046 0.013 0.0233
Leishmania major ATP-dependent phosphofructokinase 0.0046 0.013 0.0113
Mycobacterium ulcerans hypothetical protein 0.0092 0.0286 0.0281
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.0022 0.004
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0021 0.0043 0.0078
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0026 0.0059 0.0059
Schistosoma mansoni tyrosine kinase 0.0048 0.0134 0.024
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0097 0.0164
Schistosoma mansoni glutaminase 0.0132 0.0424 0.0761
Loa Loa (eye worm) hypothetical protein 0.0547 0.1852 0.1852
Trichomonas vaginalis glucosylceramidase, putative 0.0075 0.0228 0.0228
Echinococcus multilocularis synaptic glycoprotein sc2 0.1629 0.5572 1
Brugia malayi Pre-SET motif family protein 0.0015 0.0022 0.0022
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.008 0.0246 0.0246
Loa Loa (eye worm) hypothetical protein 0.0027 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0027 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.002 0.004 0.004
Mycobacterium tuberculosis Conserved hypothetical protein 0.0092 0.0286 0.1957
Brugia malayi isocitrate dehydrogenase 0.0021 0.0042 0.0042
Schistosoma mansoni hypothetical protein 0.009 0.0281 0.0505
Loa Loa (eye worm) hypothetical protein 0.002 0.004 0.004
Onchocerca volvulus Peroxidasin homolog 0.0027 0.0063 0.0114
Plasmodium vivax 6-phosphofructokinase, putative 0.0013 0.0013 0.0015
Onchocerca volvulus Protein ultraspiracle homolog 0.0032 0.008 0.0144
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0031 0.0077 0.0076
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.002 0.004 0.0072
Schistosoma mansoni tar DNA-binding protein 0.0113 0.036 0.0646
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0011 0.0011
Trypanosoma cruzi PAB1-binding protein , putative 0.0033 0.0085 0.0085
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0024 0.0023
Onchocerca volvulus 0.0011 0.0008 0.0014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0025 0.0058 0.0054
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0015 0.0024 0.0023
Trichomonas vaginalis phosphofructokinase, putative 0.0013 0.0013 0.0013
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0079 0.0241 0.0432
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0034 0.0088 0.0088
Echinococcus granulosus survival motor neuron protein 1 0.0547 0.1852 0.3323
Schistosoma mansoni lamin 0.0012 0.0011 0.002
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0014 0.0017 0.0095
Onchocerca volvulus 0.0271 0.0903 0.1621
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0005
Schistosoma mansoni apoferritin-2 0.0016 0.0026 0.0047
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0024 0.0024
Loa Loa (eye worm) isocitrate dehydrogenase 0.0021 0.0042 0.0042
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0015 0.0022 0.004
Schistosoma mansoni serine/threonine protein kinase 0.0029 0.0071 0.0128
Brugia malayi Bromodomain containing protein 0.0037 0.0098 0.0098
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0024 0.0023
Brugia malayi Pre-SET motif family protein 0.01 0.0315 0.0315
Schistosoma mansoni microtubule-associated protein tau 0.1602 0.5479 0.9831
Echinococcus granulosus neuropeptide receptor A26 0.0437 0.1474 0.2645
Echinococcus multilocularis insulin receptor 0.0048 0.0134 0.024
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0004 0.0003
Onchocerca volvulus Dual oxidase homolog 0.0027 0.0063 0.0114
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0005
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0025 0.0055 0.0054
Trichomonas vaginalis glucosylceramidase, putative 0.0114 0.0363 0.0363
Echinococcus granulosus ferritin 0.0016 0.0026 0.0047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0024 0.0023
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.004 0.004
Schistosoma mansoni RAR-like nuclear receptor 0.0032 0.008 0.0144
Trichomonas vaginalis set domain proteins, putative 0.0114 0.0362 0.0362
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0046 0.013 0.0874
Mycobacterium ulcerans hypothetical protein 0.0014 0.0017 0.0012
Plasmodium falciparum polyprenol reductase, putative 0.1629 0.5572 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0097 0.0645
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0032 0.008 0.008
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0017 0.0017
Mycobacterium tuberculosis Probable lipase LipE 0.0067 0.0202 0.1372
Echinococcus granulosus nAChR subunit 0.0011 0.0008 0.0014
Giardia lamblia Synaptic glycoprotein SC2 0.1629 0.5572 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0097 0.015
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0046 0.013 0.0129
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0025 0.0058 0.0054
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0015 0.0022 0.0022
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0031 0.0077 0.0076
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0015 0.0024 0.0007
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.008 0.0246 0.0441
Echinococcus multilocularis epidermal growth factor receptor 0.0149 0.0482 0.0864
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0032 0.008 0.008
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0034 0.0088 0.0157
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0013 0.0013 0.001
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0032 0.008 0.0144
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0025 0.0058 0.0054
Loa Loa (eye worm) TK/INSR protein kinase 0.0048 0.0134 0.0134
Onchocerca volvulus 0.0027 0.0063 0.0114
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0132 0.0425 0.0425
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.002 0.004 0.004
Schistosoma mansoni tar DNA-binding protein 0.0113 0.036 0.0646
Onchocerca volvulus 0.0037 0.0097 0.0174
Entamoeba histolytica hypothetical protein 0.005 0.0143 0.0142
Brugia malayi MH2 domain containing protein 0.0284 0.0948 0.0948
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0011 0.0008 0.0008
Echinococcus granulosus glycine receptor subunit alpha 1 0.002 0.004 0.0072
Brugia malayi nuclear receptor NHR-88 0.0032 0.008 0.008
Brugia malayi RNA binding protein 0.0113 0.036 0.036
Brugia malayi RNA recognition motif domain containing protein 0.0113 0.036 0.036
Trichomonas vaginalis CMGC family protein kinase 0.0029 0.0071 0.0071
Brugia malayi hypothetical protein 0.0009 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0018 0.0033 0.0033
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.1629 0.5572 0.5572
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0015 0.0022 0.004
Trypanosoma cruzi hypothetical protein, conserved 0.0067 0.0202 0.0201
Brugia malayi Smad1 0.0019 0.0037 0.0037
Echinococcus granulosus 6 phosphofructokinase 0.0046 0.013 0.0233
Loa Loa (eye worm) steroid hormone receptor 0.0032 0.008 0.008
Loa Loa (eye worm) ACC-1 protein 0.002 0.004 0.004
Brugia malayi MH1 domain containing protein 0.0011 0.0007 0.0007
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0042 0.0114 0.0114
Mycobacterium ulcerans hypothetical protein 0.0067 0.0202 0.0197
Loa Loa (eye worm) beta-lactamase 0.0067 0.0202 0.0202
Echinococcus multilocularis serine protein kinase ATM 0.0021 0.0043 0.0078
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0015 0.0024 0.002
Echinococcus granulosus synaptic glycoprotein sc2 0.1629 0.5572 1
Schistosoma mansoni thyroid hormone receptor 0.0032 0.008 0.0144
Loa Loa (eye worm) hypothetical protein 0.0014 0.0017 0.0017
Brugia malayi orphan nuclear receptor NR2E1 0.0015 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.0015 0.0022 0.0039
Echinococcus multilocularis nAChR subunit 0.0011 0.0008 0.0014
Mycobacterium tuberculosis Probable hydrolase 0.0067 0.0202 0.1372
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.002 0.004 0.0072
Loa Loa (eye worm) hypothetical protein 0.2917 1 1
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0016 0.0026 0.0159
Trichomonas vaginalis CMGC family protein kinase 0.0029 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.002 0.004 0.004
Brugia malayi mbt repeat family protein 0.0023 0.0048 0.0048
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0028 0.0051
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.008 0.0246 0.0441
Leishmania major phosphatidylinositol kinase related protein, putative 0.0016 0.0024 0.0007
Echinococcus multilocularis Smad4 0.0019 0.0037 0.0066
Loa Loa (eye worm) 6-phosphofructokinase 0.0046 0.013 0.013
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.003 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0027 0.0063 0.0063
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0021 0.0042 0.0025
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0015 0.0022 0.0039
Brugia malayi hypothetical protein 0.0009 0.0002 0.0002
Trichomonas vaginalis phosphofructokinase, putative 0.0046 0.013 0.0129
Entamoeba histolytica acyl-CoA synthetase, putative 0.0014 0.0017 0.0017
Schistosoma mansoni retinoic acid receptor RXR 0.0032 0.008 0.0144
Loa Loa (eye worm) ACC-1 protein 0.002 0.004 0.004
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.008 0.008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0024 0.0023
Echinococcus granulosus histone lysine methyltransferase setb 0.0023 0.005 0.0089
Loa Loa (eye worm) phosphofructokinase 0.0046 0.013 0.013
Schistosoma mansoni hypothetical protein 0.0042 0.0114 0.0205
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0011 0.002
Echinococcus multilocularis epidermal growth factor receptor 0.008 0.0245 0.044
Trichomonas vaginalis esterase, putative 0.0067 0.0202 0.0201
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0032 0.008 0.008
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0009 0.0002 0.0004
Echinococcus granulosus tar DNA binding protein 0.0113 0.036 0.0646
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0063 0.0063
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.004 0.004
Trichomonas vaginalis phosphofructokinase, putative 0.0046 0.013 0.0129
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0097 0.0164
Echinococcus granulosus FTZ F1 alpha 0.0032 0.008 0.0144
Onchocerca volvulus 0.0014 0.0017 0.0031
Onchocerca volvulus 0.0107 0.0337 0.0604
Echinococcus granulosus lamin 0.0012 0.0011 0.002
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0067 0.0202 0.0202
Brugia malayi beta-lactamase family protein 0.0067 0.0202 0.0202
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0015 0.0024 0.0042
Trichomonas vaginalis glucosylceramidase, putative 0.0075 0.0228 0.0228
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0009 0.0002 0.0002
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0063 0.0063
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0048 0.0134 0.024
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0075 0.0228 0.0228
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.1629 0.5572 0.5572
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.002 0.004 0.0072
Brugia malayi nuclear receptor NHR-88 0.0015 0.0022 0.0022
Echinococcus granulosus fetal alzheimer antigen falz 0.0013 0.0014 0.0025
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.002 0.004 0.004
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0032 0.008 0.0144
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0013 0.0013 1
Echinococcus granulosus metabotropic glutamate receptor 5 0.0022 0.0046 0.0083
Brugia malayi 6-phosphofructokinase 0.0046 0.013 0.013
Brugia malayi Cation transporter family protein 0.002 0.004 0.004
Onchocerca volvulus Peroxidase homolog 0.0027 0.0063 0.0114
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0097 0.0097
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0031 0.0077 0.0137
Trichomonas vaginalis conserved hypothetical protein 0.1629 0.5572 0.5572
Echinococcus granulosus thyroid hormone receptor alpha 0.0015 0.0022 0.004
Onchocerca volvulus 0.1629 0.5572 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.0022 0.004
Brugia malayi glutaminase DH11.1 0.0132 0.0424 0.0424
Schistosoma mansoni cpg binding protein 0.004 0.0107 0.0192
Schistosoma mansoni smad1 5 8 and 0.0019 0.0037 0.0066
Onchocerca volvulus 0.0067 0.0202 0.0362
Trichomonas vaginalis glucosylceramidase, putative 0.0075 0.0228 0.0228
Mycobacterium tuberculosis Conserved protein 0.0067 0.0202 0.1372
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0009 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0002
Brugia malayi Bromodomain containing protein 0.0018 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0067 0.0202 0.0202
Echinococcus multilocularis microtubule associated protein 2 0.1602 0.5479 0.9831
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0002
Schistosoma mansoni neurotransmitter gated ion channel 0.0011 0.0008 0.0014
Loa Loa (eye worm) TAR-binding protein 0.0113 0.036 0.036
Loa Loa (eye worm) hypothetical protein 0.0032 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.002 0.004 0.004
Trichomonas vaginalis conserved hypothetical protein 0.1629 0.5572 0.5572
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.005 0.0143 0.0256
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0024 0.0023
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0015 0.0024 0.0042
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.004 0.004
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0042 0.0114 0.0205
Echinococcus granulosus lamin dm0 0.0012 0.0011 0.002
Loa Loa (eye worm) hypothetical protein 0.0023 0.005 0.005
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0097 0.0096
Echinococcus multilocularis histone acetyltransferase MYST2 0.0026 0.0059 0.0106
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.2917 1 1
Schistosoma mansoni ap endonuclease 0.0037 0.0097 0.0173
Loa Loa (eye worm) hypothetical protein 0.002 0.004 0.004
Loa Loa (eye worm) PHD-finger family protein 0.001 0.0003 0.0003
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0032 0.008 0.0144
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.002 0.004 0.0072
Loa Loa (eye worm) hypothetical protein 0.0032 0.008 0.008
Schistosoma mansoni neurotransmitter gated ion channel 0.0009 0.0002 0.0004
Echinococcus granulosus serine protein kinase ATM 0.0021 0.0043 0.0078
Leishmania major cathepsin L-like protease 0.0025 0.0058 0.0041
Loa Loa (eye worm) hypothetical protein 0.0015 0.0022 0.0022
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0034 0.0088 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.008 0.008
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0097 0.0096
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0005
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0017 0.0017
Plasmodium falciparum ataxin-2 like protein, putative 0.0033 0.0085 0.0144
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0032 0.008 0.008
Brugia malayi CXXC zinc finger family protein 0.0037 0.0097 0.0097
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0069 0.0208 0.0203
Loa Loa (eye worm) hypothetical protein 0.002 0.004 0.004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0025 0.0058 0.0054
Trypanosoma brucei hypothetical protein, conserved 0.0067 0.0202 0.0198
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.004 0.004
Brugia malayi hypothetical protein 0.0033 0.0085 0.0085
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0083 0.0254 0.025
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.002 0.004 0.0072
Loa Loa (eye worm) hypothetical protein 0.0027 0.0063 0.0063
Mycobacterium tuberculosis Possible penicillin-binding protein 0.043 0.1449 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.002 0.004 0.0072
Brugia malayi beta-lactamase family protein 0.0067 0.0202 0.0202
Brugia malayi Cation transporter family protein 0.002 0.004 0.004
Echinococcus granulosus cpg binding protein 0.004 0.0107 0.0192
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.002 0.004 0.0072
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0009 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0027 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0032 0.008 0.008
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0016 0.0026 0.0159
Mycobacterium tuberculosis Conserved protein 0.0067 0.0202 0.1372
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0015 0.0022 0.0018
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0097 0.0302 0.0543
Brugia malayi Calcitonin receptor-like protein seb-1 0.0132 0.0425 0.0425
Echinococcus multilocularis GPCR, family 2 0.0042 0.0114 0.0205
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0025 0.0055 0.0054
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.1629 0.5572 0.5571
Echinococcus multilocularis nuclear receptor nhr 48 0.0015 0.0022 0.004
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0017 0.0017
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0083 0.0254 0.0237
Loa Loa (eye worm) GABA receptor subunit 0.0011 0.0008 0.0008
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0017 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0024 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0024 0.0023
Schistosoma mansoni smad1 5 8 and 0.0019 0.0037 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0004 0.0003
Schistosoma mansoni hypothetical protein 0.001 0.0003 0.0006
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0026 0.0059 0.0106
Schistosoma mansoni 6-phosphofructokinase 0.0046 0.013 0.0233
Mycobacterium ulcerans 6-phosphofructokinase 0.0046 0.013 0.0125
Brugia malayi hypothetical protein 0.0017 0.0028 0.0028
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0032 0.008 0.008
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0132 0.0425 0.0425
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0026 0.0059 0.0106
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0023 0.005 0.0089
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0028 0.0028
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0008
Toxoplasma gondii phosphofructokinase PFKII 0.0013 0.0013 0.001
Trypanosoma cruzi cysteine peptidase, putative 0.0025 0.0058 0.0057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0024 0.0023
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.008 0.0246 0.0441
Trichomonas vaginalis glucosylceramidase, putative 0.0075 0.0228 0.0228
Plasmodium vivax SET domain protein, putative 0.0015 0.0022 0.003
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.2917 1 1
Brugia malayi MH1 domain containing protein 0.0011 0.0007 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0024 0.0023
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0067 0.0202 0.1372
Giardia lamblia Kinase, CMGC MAPK 0.0029 0.0071 0.0105
Loa Loa (eye worm) hypothetical protein 0.0017 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0187 0.0614 0.0614
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0015 0.0022 0.004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0025 0.0058 0.0054
Loa Loa (eye worm) hypothetical protein 0.0067 0.0202 0.0202
Loa Loa (eye worm) hypothetical protein 0.0027 0.0063 0.0063
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0011 0.0008 0.0008
Echinococcus multilocularis SAM and MBT domain containing protein 0.0023 0.0048 0.0086
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0017 0.0028 0.0028
Schistosoma mansoni steroid hormone receptor ad4bp 0.0032 0.008 0.0144
Loa Loa (eye worm) hypothetical protein 0.0067 0.0202 0.0202
Loa Loa (eye worm) MH2 domain-containing protein 0.0284 0.0948 0.0948
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0067 0.0202 0.1372
Echinococcus granulosus glycine receptor subunit beta 0.002 0.004 0.0072
Mycobacterium tuberculosis Naphthoate synthase MenB (dihydroxynaphthoic acid synthetase) (DHNA synthetase) 0.0232 0.0768 0.5291
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0046 0.013 0.0126
Echinococcus multilocularis geminin 0.0575 0.1947 0.3494
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.1629 0.5572 0.5572
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.1629 0.5572 1
Mycobacterium ulcerans esterase/lipase LipP 0.0067 0.0202 0.0197
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.002 0.004 0.004
Trichomonas vaginalis penicillin-binding protein, putative 0.0067 0.0202 0.0201
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0024 0.0023
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0024 0.0023
Toxoplasma gondii histone lysine methyltransferase SET1 0.0071 0.0216 0.0212
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0024 0.0023
Echinococcus granulosus dnaJ subfamily B 0.0174 0.057 0.1023
Entamoeba histolytica hypothetical protein 0.005 0.0143 0.0142
Echinococcus multilocularis muscleblind protein 1 0.007 0.0211 0.0378
Brugia malayi hypothetical protein 0.0027 0.0063 0.0063
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.003 0.0074 0.0132
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0022 0.0046 0.0083
Loa Loa (eye worm) DR-78 0.0015 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0271 0.0903 0.0903
Entamoeba histolytica phosphofructokinase, putative 0.0046 0.013 0.0129
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.002 0.004 0.004
Onchocerca volvulus 0.0015 0.0022 0.004
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0097 0.0173
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0034 0.0088 0.0083
Trichomonas vaginalis phosphofructokinase, putative 0.0046 0.013 0.0129
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0002
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0021 0.0043 0.0043
Echinococcus multilocularis mothers against decapentaplegic 5 0.0019 0.0037 0.0066
Schistosoma mansoni smad1 5 8 and 0.0019 0.0037 0.0066
Onchocerca volvulus 0.002 0.004 0.0072
Trichomonas vaginalis glucosylceramidase, putative 0.0114 0.0363 0.0363
Toxoplasma gondii target of rapamycin (TOR), putative 0.0015 0.0024 0.002
Echinococcus multilocularis smad 0.0019 0.0037 0.0066
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.002 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0015 0.0022 0.0022
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.002 0.004 0.004
Schistosoma mansoni acetylcholine receptor-related 0.0009 0.0002 0.0004
Schistosoma mansoni nAChR subunit 0.0009 0.0002 0.0004
Schistosoma mansoni nAChR subunit 0.002 0.004 0.0072
Onchocerca volvulus 0.0027 0.0063 0.0114
Schistosoma mansoni hypothetical protein 0.005 0.0143 0.0256
Schistosoma mansoni tyrosine kinase 0.0149 0.0482 0.0864
Brugia malayi Muscleblind-like protein 0.007 0.0211 0.0211
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0063 0.0063
Brugia malayi ecdysone receptor 0.0015 0.0022 0.0022
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0015 0.0022 0.004
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.003 0.0074 0.0132
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0042 0.0114 0.0205
Schistosoma mansoni nuclear hormone receptor 0.0032 0.008 0.0144
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0097 0.0096
Schistosoma mansoni nAChR subunit 0.002 0.004 0.0072
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0031 0.0077 0.0137
Plasmodium vivax hypothetical protein, conserved 0.0067 0.0202 0.0353
Brugia malayi Blistered cuticle protein 3 0.0027 0.0063 0.0063
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0025 0.0055 0.0054
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.002 0.004 0.0072
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0021 0.0042 0.0067
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0075 0.0228 0.0409
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.002 0.004 0.0072
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0063 0.0063
Mycobacterium leprae Probable lipase LipE 0.0067 0.0202 0.2458
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0097 0.0302 0.0543
Onchocerca volvulus 0.0112 0.0354 0.0635
Brugia malayi Synaptic glycoprotein SC2 0.1629 0.5572 0.5572

Activities

Activity type Activity value Assay description Source Reference
MFC (functional) = 6.3 ug ml-1 Minimum fungicidal concentration was determined against C. albicans 3153A strain ChEMBL. 2299651
MFC (functional) = 6.3 ug ml-1 Minimum fungicidal concentration was determined against C. albicans 3153A strain ChEMBL. 2299651
MIC (functional) = 3.1 ug ml-1 Minimum inhibitory concentration was determined against C. albicans 3153A strain ChEMBL. 2299651
MIC (functional) = 3.1 ug ml-1 Minimum inhibitory concentration was determined against C. albicans 3153A strain ChEMBL. 2299651
No. of survivors (functional) = 4 The number of survivors/total infected at day 14 was determined after (ip) administration of 2 mg/kg in C. albicans infected mice; 4/10 ChEMBL. 2299651
No. of survivors (functional) = 4 The number of survivors/total infected at day 14 was determined after (ip) administration of 2 mg/kg in C. albicans infected mice; 4/10 ChEMBL. 2299651

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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