Detailed information for compound 309817

Basic information

Technical information
  • TDR Targets ID: 309817
  • Name: 2-[(1R)-1-[[(2S)-2-[[cyclohexyl(methyl)carbam oyl]amino]-4-methylpentanoyl]amino]-2-(1-meth ylindol-3-yl)ethyl]-5-methyl-1,3-oxazole-4-ca rboxylic acid
  • MW: 551.677 | Formula: C30H41N5O5
  • H donors: 3 H acceptors: 5 LogP: 4.7 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC(C[C@@H](C(=O)N[C@@H](c1oc(c(n1)C(=O)O)C)Cc1cn(c2c1cccc2)C)NC(=O)N(C1CCCCC1)C)C
  • InChi: 1S/C30H41N5O5/c1-18(2)15-23(32-30(39)35(5)21-11-7-6-8-12-21)27(36)31-24(28-33-26(29(37)38)19(3)40-28)16-20-17-34(4)25-14-10-9-13-22(20)25/h9-10,13-14,17-18,21,23-24H,6-8,11-12,15-16H2,1-5H3,(H,31,36)(H,32,39)(H,37,38)/t23-,24+/m0/s1
  • InChiKey: CYNRTRAOTKDFNE-BJKOFHAPSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(1R)-1-[[(2S)-2-[[cyclohexyl(methyl)carbamoyl]amino]-4-methyl-pentanoyl]amino]-2-(1-methylindol-3-yl)ethyl]-5-methyl-oxazole-4-carboxylic acid
  • 2-[(1R)-1-[[(2S)-2-[[[cyclohexyl(methyl)amino]-oxomethyl]amino]-4-methyl-1-oxopentyl]amino]-2-(1-methyl-3-indolyl)ethyl]-5-methyl-4-oxazolecarboxylic acid
  • 2-[(1R)-1-[[(2S)-2-[[cyclohexyl(methyl)carbamoyl]amino]-4-methyl-pentanoyl]amino]-2-(1-methylindol-3-yl)ethyl]-5-methyl-1,3-oxazole-4-carboxylic acid
  • 2-[(1R)-1-[[(2S)-2-[(cyclohexyl-methylcarbamoyl)amino]-4-methylpentanoyl]amino]-2-(1-methylindol-3-yl)ethyl]-5-methyl-1,3-oxazole-4-carboxylic acid
  • 2-[(1R)-1-[[(2S)-2-[(cyclohexyl-methyl-carbamoyl)amino]-4-methyl-pentanoyl]amino]-2-(1-methylindol-3-yl)ethyl]-5-methyl-oxazole-4-carboxylic acid
  • 2-[(1R)-1-[[(2S)-2-[[(cyclohexyl-methylamino)-oxomethyl]amino]-4-methyl-1-oxopentyl]amino]-2-(1-methyl-3-indolyl)ethyl]-5-methyl-4-oxazolecarboxylic acid
  • 2-[(1R)-1-[[(2S)-2-[(cyclohexyl-methyl-carbamoyl)amino]-4-methyl-pentanoyl]amino]-2-(1-methylindol-3-yl)ethyl]-5-methyl-1,3-oxazole-4-carboxylic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens endothelin receptor type B Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major i/6 autoantigen-like protein 0.018 0.0224 0.1168
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0003 0.0003
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0007 0.0008
Schistosoma mansoni hypothetical protein 0.018 0.0224 0.0224
Schistosoma mansoni cpg binding protein 0.0059 0.006 0.006
Echinococcus multilocularis calumenin 0.0184 0.0229 0.0588
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0433 0.0566 0.5842
Schistosoma mansoni cathepsin F (C01 family) 0.0375 0.0488 0.0488
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.1349 0.1802 0.1802
Onchocerca volvulus Glucosylceramidase homolog 0.0178 0.022 0.1045
Trypanosoma cruzi calmodulin, putative 0.018 0.0224 0.08
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0532 0.0699 1
Brugia malayi Intermediate filament tail domain containing protein 0.0055 0.0055 0.0151
Trichomonas vaginalis calmodulin, putative 0.018 0.0224 0.2289
Echinococcus multilocularis cathepsin L cysteine protease 0.0532 0.0699 0.1795
Entamoeba histolytica calpain large subunit domain III containing protein 0.0705 0.0933 1
Schistosoma mansoni cpg binding protein 0.0063 0.0065 0.0065
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2033 0.2727 0.2727
Loa Loa (eye worm) calpain family protein 1 0.2008 0.2693 0.7387
Trypanosoma brucei centrin, putative 0.018 0.0224 0.1168
Echinococcus granulosus Mastin 0.0041 0.0036 0.0092
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0007 0.0018
Entamoeba histolytica cysteine protease, putative 0.0302 0.0389 0.4127
Trichomonas vaginalis kakapo, putative 0.005 0.0047 0.0452
Toxoplasma gondii ABC1 family protein 0.0036 0.0029 0.0227
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0023
Trichomonas vaginalis calpain, putative 0.0433 0.0566 0.5842
Leishmania major calpain family cysteine protease-like protein 0.0638 0.0843 0.4489
Echinococcus multilocularis importin subunit beta 1 0.003 0.0021 0.0054
Entamoeba histolytica cysteine protease, putative 0.0302 0.0389 0.4127
Loa Loa (eye worm) hypothetical protein 0.0027 0.0016 0.0045
Schistosoma mansoni myosin regulatory light chain 0.005 0.0047 0.0047
Entamoeba histolytica cysteine protease, putative 0.0146 0.0177 0.1845
Schistosoma mansoni calpain (C02 family) 0.1139 0.1519 0.1519
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0146 0.0177 0.0177
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0105 0.027
Schistosoma mansoni thyroid hormone receptor 0.0146 0.0178 0.0178
Brugia malayi programmed cell death protein 6 0.018 0.0224 0.0615
Leishmania major calmodulin-like protein 0.018 0.0224 0.1168
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0041 0.0036 0.0036
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0022 0.0009 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0433 0.0566 0.5842
Echinococcus multilocularis lamin dm0 0.0055 0.0055 0.0141
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.1399 0.187 1
Trypanosoma brucei metacaspase 5, putative 0.0045 0.0041 0.0183
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0974 0.1297 0.6925
Loa Loa (eye worm) glutathione reductase 0.0093 0.0106 0.029
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0032 0.0024 0.0174
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0772 0.1024 0.5458
Leishmania major phospholipase c-like protein 0.018 0.0224 0.1168
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0146 0.0177 0.1845
Toxoplasma gondii centrin family protein 0.005 0.0047 0.042
Leishmania major hypothetical protein, conserved 0.0205 0.0257 0.1348
Schistosoma mansoni lamin 0.0055 0.0055 0.0055
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0008 0.0023
Toxoplasma gondii histone lysine methyltransferase SET1 0.0113 0.0133 0.1315
Loa Loa (eye worm) hypothetical protein 0.1575 0.2108 0.5781
Loa Loa (eye worm) hypothetical protein 0.0036 0.0029 0.0079
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.018 0.0224 0.08
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0002 0.0004
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0029 0.026
Trypanosoma cruzi hypothetical protein, conserved 0.0205 0.0257 0.0923
Leishmania major calpain protease-like protein 0.0433 0.0566 0.3002
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0041 0.0381
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0008 0.0023
Leishmania major cathepsin L-like protease 0.0532 0.0699 0.3718
Schistosoma mansoni calmodulin-related 0.005 0.0047 0.0047
Schistosoma mansoni hypothetical protein 0.0041 0.0036 0.0036
Onchocerca volvulus 0.0041 0.0036 0.017
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.001 0.0015
Trichomonas vaginalis centrin, putative 0.005 0.0047 0.0452
Onchocerca volvulus 0.0059 0.006 0.0285
Entamoeba histolytica cysteine protease, putative 0.0302 0.0389 0.4127
Trypanosoma brucei calpain-like protein, putative 0.1139 0.1519 0.8115
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0638 0.0843 0.3075
Leishmania major hypothetical protein, conserved 0.0184 0.0229 0.1195
Trypanosoma brucei unspecified product 0.0205 0.0257 0.1348
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0974 0.1297 0.4743
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0532 0.0699 0.7228
Trypanosoma brucei conserved protein 0.0214 0.0269 0.1411
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.073 0.0966 0.5149
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0532 0.0699 0.7228
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0008 0.0023
Schistosoma mansoni cercarial elastase (S01 family) 0.0041 0.0036 0.0036
Trichomonas vaginalis calcium binding protein, putative 0.018 0.0224 0.2289
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0032 0.0024 0.0263
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0532 0.0699 0.7228
Loa Loa (eye worm) beta-lactamase 0.0036 0.0029 0.0079
Schistosoma mansoni ef hand domain family member A2 0.018 0.0224 0.0224
Schistosoma mansoni myosin regulatory light chain 0.005 0.0047 0.0047
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0433 0.0566 0.5842
Trichomonas vaginalis calmodulin, putative 0.018 0.0224 0.2289
Mycobacterium ulcerans hypothetical protein 0.0041 0.0036 0.4924
Trichomonas vaginalis calmodulin, putative 0.018 0.0224 0.2289
Entamoeba histolytica cysteine proteinase, putative 0.0302 0.0389 0.4127
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0041 0.0036 0.0092
Trypanosoma brucei Calpain-like protein 2 0.0763 0.1012 0.5395
Leishmania major hypothetical protein, conserved 0.0205 0.0257 0.1348
Leishmania major hypothetical protein, conserved,calpain-like cysteine peptidase, Clan CA, family C2 0.0205 0.0257 0.1348
Trypanosoma cruzi centrin-3 0.023 0.0291 0.1046
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.0117 0.032
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0146 0.0177 0.1804
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0024 0.0065
Trichomonas vaginalis caltractin, putative 0.005 0.0047 0.0452
Leishmania major hypothetical protein, conserved 0.0205 0.0257 0.1348
Trypanosoma cruzi cysteine proteinase, putative 0.0302 0.0389 0.1406
Trypanosoma brucei META domain/Domain of unknown function (DUF1935), putative 0.0205 0.0257 0.1348
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0212 0.0266 0.8907
Brugia malayi Papain family cysteine protease containing protein 0.0146 0.0177 0.0486
Trypanosoma brucei trypanothione reductase 0.0093 0.0106 0.0533
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0146 0.0177 0.1804
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0023 0.0163
Schistosoma mansoni ran 0.0022 0.001 0.001
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0008 0.0021
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0041 0.0036 0.0099
Loa Loa (eye worm) intermediate filament protein 0.0055 0.0055 0.0151
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.0105 0.0288
Onchocerca volvulus 0.018 0.0224 0.1062
Trypanosoma cruzi Domain of unknown function (DUF1935), putative 0.0205 0.0257 0.0923
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0042 0.0037 0.0037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0532 0.0699 0.7228
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0772 0.1024 0.5458
Loa Loa (eye worm) hypothetical protein 0.005 0.0047 0.013
Trypanosoma cruzi kinesin, putative 0.0705 0.0933 0.3407
Echinococcus granulosus lamin 0.0055 0.0055 0.0141
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0029 0.0074
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0007 0.0003
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0008 0.0008
Echinococcus granulosus nuclear factor of activated T cells 5 0.0073 0.0079 0.0204
Loa Loa (eye worm) hypothetical protein 0.0041 0.0036 0.0099
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0022 0.0159
Loa Loa (eye worm) hypothetical protein 0.0041 0.0036 0.0099
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0032 0.0024 0.0094
Echinococcus granulosus cathepsin l1 0.0532 0.0699 0.1795
Onchocerca volvulus 0.0041 0.0036 0.017
Toxoplasma gondii NADPH-glutathione reductase 0.0032 0.0024 0.0174
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0212 0.0266 0.8907
Loa Loa (eye worm) hypothetical protein 0.0069 0.0074 0.0202
Trypanosoma brucei Calpain-like protein 1.2 0.0781 0.1036 0.5523
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0022 0.0022
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.2033 0.2727 1
Trypanosoma brucei calmodulin, putative 0.0184 0.0229 0.1195
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0041 0.0381
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0029 0.3729
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0146 0.0177 0.0177
Brugia malayi Trypsin family protein 0.0041 0.0036 0.0099
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0023
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0781 0.1036 0.3783
Echinococcus granulosus calpain 7 C02 family 0.1139 0.1519 0.3899
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0532 0.0699 0.7228
Leishmania major GTP-binding protein, putative 0.0022 0.001 0.0022
Plasmodium vivax unspecified product 0.0302 0.0389 0.2526
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0002 0.0004
Schistosoma mansoni hypothetical protein 0.0051 0.005 0.005
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0048 0.0268
Trypanosoma cruzi metacaspase, putative 0.0045 0.0041 0.0126
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0146 0.0177 0.1804
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0024 0.0094
Echinococcus granulosus cathepsin L cysteine proteinase 0.0532 0.0699 0.1795
Trichomonas vaginalis bollus pemphigoid antigen, putative 0.005 0.0047 0.0452
Echinococcus multilocularis Calcium binding protein 0.005 0.0047 0.0122
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.0262 0.0719
Trypanosoma cruzi metacaspase, putative 0.0045 0.0041 0.0126
Loa Loa (eye worm) calcium binding EGF domain-containing protein 0.0052 0.005 0.0138
Brugia malayi Protein kinase domain containing protein 0.0022 0.0009 0.0026
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0772 0.1024 0.5458
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0932 0.1239 0.6614
Brugia malayi Papain family cysteine protease containing protein 0.0146 0.0177 0.0486
Schistosoma mansoni calmodulin related calcium binding protein 0.018 0.0224 0.0224
Schistosoma mansoni ap endonuclease 0.002 0.0007 0.0007
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0024 0.0064
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0005 0.0014
Giardia lamblia NADH oxidase lateral transfer candidate 0.0032 0.0024 0.0182
Toxoplasma gondii troponin c, isotype gamma, putative 0.018 0.0224 0.2263
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0212 0.0266 0.8907
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0621 0.0819 0.4361
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.0233 0.2384
Toxoplasma gondii kringle domain-containing protein 0.0022 0.0009 0.0025
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0029 0.0083
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0302 0.0389 0.4003
Schistosoma mansoni centrin 0.018 0.0224 0.0224
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0036 0.0333
Loa Loa (eye worm) hypothetical protein 0.0028 0.0018 0.0049
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0006 0.0016
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0041 0.0381
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.001 0.0027
Mycobacterium ulcerans lipase LipD 0.0036 0.0029 0.3729
Echinococcus granulosus enteropeptidase 0.0041 0.0036 0.0092
Onchocerca volvulus 0.0036 0.0029 0.0136
Entamoeba histolytica cysteine protease, putative 0.0532 0.0699 0.7475
Echinococcus granulosus geminin 0.0334 0.0432 0.1109
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0532 0.0699 0.7228
Leishmania major hypothetical protein, conserved 0.0205 0.0257 0.1348
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0011 0.0027
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0013 0.0026
Trypanosoma cruzi trypanothione reductase, putative 0.0093 0.0106 0.0365
Trichomonas vaginalis calcium binding protein, putative 0.018 0.0224 0.2289
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0029 0.0079
Trypanosoma cruzi trypanothione reductase, putative 0.0032 0.0024 0.0064
Schistosoma mansoni cercarial elastase (S01 family) 0.0041 0.0036 0.0036
Plasmodium falciparum serine repeat antigen 8 0.0146 0.0177 0.2476
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0008 0.0021
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0433 0.0566 0.5842
Leishmania major hypothetical protein, conserved 0.018 0.0224 0.1168
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0029 0.0074
Brugia malayi hypothetical protein 0.0032 0.0024 0.0065
Entamoeba histolytica cysteine proteinase, putative 0.0532 0.0699 0.7475
Trypanosoma brucei calpain-like protein, putative 0.1399 0.187 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0036 0.0099
Onchocerca volvulus 0.005 0.0047 0.0224
Brugia malayi Papain family cysteine protease containing protein 0.0302 0.0389 0.1067
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0002 0.0002
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0048 0.0422
Echinococcus multilocularis enteropeptidase 0.0041 0.0036 0.0092
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0256 0.0326 0.0894
Echinococcus multilocularis chromobox protein 1 0.0068 0.0072 0.0186
Loa Loa (eye worm) hypothetical protein 0.003 0.0021 0.0057
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0532 0.0699 0.1795
Trypanosoma cruzi cysteine peptidase, putative 0.0772 0.1024 0.3739
Echinococcus multilocularis neuropeptide s receptor 0.0497 0.0652 0.1673
Brugia malayi beta-lactamase 0.0036 0.0029 0.0079
Onchocerca volvulus 0.0036 0.0029 0.0136
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0036 0.0333
Toxoplasma gondii thioredoxin reductase 0.0093 0.0106 0.1028
Loa Loa (eye worm) cysteine protease 0.0532 0.0699 0.1918
Loa Loa (eye worm) hypothetical protein 0.0375 0.0488 0.1337
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0024 0.0064
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0022 0.0057
Onchocerca volvulus 0.0041 0.0036 0.017
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.0024 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0532 0.0699 0.7228
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0772 0.1024 0.5458
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0146 0.0177 0.1126
Schistosoma mansoni calpain C (C02 family) 0.1139 0.1519 0.1519
Schistosoma mansoni cercarial elastase (S01 family) 0.0041 0.0036 0.0036
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0532 0.0699 0.7228
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0532 0.0699 0.7228
Plasmodium vivax hypothetical protein, conserved 0.0184 0.0229 0.1468
Trypanosoma cruzi cysteine protease, putative 0.0302 0.0389 0.1406
Brugia malayi steroid hormone receptor 0.0021 0.0008 0.0023
Giardia lamblia Cathepsin B precursor 0.0146 0.0177 0.1782
Brugia malayi Cathepsin L-like precursor 0.0532 0.0699 0.1918
Brugia malayi beta-lactamase family protein 0.0036 0.0029 0.0079
Giardia lamblia Cathepsin L precursor 0.0146 0.0177 0.1782
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.022 0.225
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0781 0.1036 0.5523
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0008 0.0021
Brugia malayi CXXC zinc finger family protein 0.0059 0.006 0.0165
Trypanosoma cruzi cysteine peptidase, putative 0.0157 0.0192 0.0682
Loa Loa (eye worm) hypothetical protein 0.0157 0.0192 0.0526
Leishmania major small myristoylated protein-3, putative 0.03 0.0385 0.2034
Brugia malayi Trypsin-like protease protein 5 0.0041 0.0036 0.0099
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0749 0.0993 0.3625
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0029 0.026
Mycobacterium ulcerans beta-lactamase 0.0036 0.0029 0.3729
Trypanosoma brucei protein I/6 0.018 0.0224 0.1168
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 33 0.018 0.0224 0.1168
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0029 0.077
Trichomonas vaginalis calpain, putative 0.0433 0.0566 0.5842
Echinococcus multilocularis cathepsin b 0.2033 0.2727 0.7001
Trichomonas vaginalis calcium binding proteins, putative 0.018 0.0224 0.2289
Echinococcus granulosus neuropeptide s receptor 0.0497 0.0652 0.1673
Entamoeba histolytica cysteine protease, putative 0.0146 0.0177 0.1845
Plasmodium vivax vivapain-2 0.0532 0.0699 0.4579
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0146 0.0177 0.1126
Onchocerca volvulus 0.0041 0.0036 0.017
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0032 0.0024 0.2899
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0041 0.0036 0.0036
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.0067 0.0621
Trypanosoma cruzi unspecified product 0.0354 0.0458 0.1662
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0008 0.0021
Loa Loa (eye worm) hypothetical protein 0.0036 0.0029 0.0079
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0032 0.0024 0.0111
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0638 0.0843 0.4489
Loa Loa (eye worm) calmodulin-like protein 0.018 0.0224 0.0615
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.022 0.225
Trypanosoma brucei calpain-like protein, putative 0.1139 0.1519 0.8115
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0006 0.0026
Plasmodium falciparum cysteine proteinase falcipain 3 0.0532 0.0699 1
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0008 0.0023
Echinococcus granulosus apoptotic protease activating factor 1 0.0042 0.0037 0.0095
Trypanosoma brucei metacaspase MCA2 0.0045 0.0041 0.0183
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0008 0.0023
Echinococcus granulosus dna polymerase eta 0.0045 0.0041 0.0104
Echinococcus granulosus dna polymerase kappa 0.0019 0.0006 0.0016
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0532 0.0699 0.1918
Echinococcus granulosus sarcoplasmic calcium binding protein 0.018 0.0224 0.0575
Echinococcus multilocularis hypothetical protein 0.1139 0.1519 0.3899
Trichomonas vaginalis calcineurin B subunit, putative 0.0184 0.0229 0.2341
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0008 0.0008
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.2714 0.3646 0.3646
Entamoeba histolytica calmodulin, putative 0.018 0.0224 0.2349
Trypanosoma cruzi hypothetical protein, conserved 0.0205 0.0257 0.0923
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1399 0.187 0.685
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0036 0.017
Echinococcus multilocularis geminin 0.0334 0.0432 0.1109
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0532 0.0699 0.1918
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0032 0.0024 0.0111
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0772 0.1024 0.5458
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0002 0.0004
Leishmania major cathepsin L-like protease 0.0772 0.1024 0.5458
Brugia malayi Papain family cysteine protease containing protein 0.0532 0.0699 0.1918
Loa Loa (eye worm) calpain 0.1139 0.1519 0.4165
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.1139 0.1519 0.5559
Brugia malayi nuclear receptor NHR-88 0.0021 0.0008 0.0023
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0008 0.0021
Loa Loa (eye worm) hypothetical protein 0.0031 0.0022 0.0061
Trichomonas vaginalis centrin, putative 0.018 0.0224 0.2289
Schistosoma mansoni hypothetical protein 0.0069 0.0074 0.0074
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0781 0.1036 0.3783
Giardia lamblia Cathepsin L precursor 0.0146 0.0177 0.1782
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0024 0.0065
Plasmodium falciparum cysteine proteinase falcipain 1 0.0302 0.0389 0.5526
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0023
Leishmania major hypothetical protein, unknown function 0.0433 0.0566 0.3002
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0974 0.1297 0.6925
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0026 0.0016 0.0044
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0146 0.0177 0.1782
Entamoeba histolytica cysteine protease, putative 0.0302 0.0389 0.4127
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0146 0.0177 0.0177
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0008 0.0023
Brugia malayi Heterochromatin protein 1 0.0068 0.0072 0.0199
Plasmodium falciparum cysteine repeat modular protein 1 0.0022 0.0009 0.0056
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0146 0.0177 0.0486
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0638 0.0843 0.4489
Echinococcus granulosus calmodulin 0.018 0.0224 0.0575
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0532 0.0699 0.7228
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0067 1
Brugia malayi Calmodulin-like protein 0.018 0.0224 0.0615
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0067 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0772 0.1024 0.5458
Entamoeba histolytica cysteine protease, putative 0.0302 0.0389 0.4127
Schistosoma mansoni mitochondrial solute carrier 0.018 0.0224 0.0224
Trichomonas vaginalis calcium binding protein, putative 0.018 0.0224 0.2289
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1139 0.1519 0.5559
Entamoeba histolytica protein kinase, putative 0.0705 0.0933 1
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0146 0.0177 0.2476
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0541 0.0711 0.2592
Schistosoma mansoni neuronal calcium sensor 0.018 0.0224 0.0224
Toxoplasma gondii centrin 0.018 0.0224 0.2263
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0146 0.0177 0.1804
Brugia malayi chromobox protein homolog 3 0.0038 0.0032 0.0088
Leishmania major cathepsin L-like protease 0.0532 0.0699 0.3718
Toxoplasma gondii cathepsin CPC2 0.0146 0.0177 0.1776
Brugia malayi glutathione reductase 0.0093 0.0106 0.029
Brugia malayi cathepsin Z-like cysteine proteinase 0.0146 0.0177 0.0486
Loa Loa (eye worm) hypothetical protein 0.0036 0.0029 0.0079
Trypanosoma brucei Component of motile flagella 41 0.018 0.0224 0.1168
Entamoeba histolytica hypothetical protein 0.0146 0.0177 0.1845
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0146 0.0177 0.1804
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0048 0.0605
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0045 0.0041 0.0349
Schistosoma mansoni hypothetical protein 0.0032 0.0024 0.0024
Schistosoma mansoni cathepsin B (C01 family) 0.0146 0.0177 0.0177
Onchocerca volvulus 0.0532 0.0699 0.3317
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0532 0.0699 0.7228
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0024 0.0064
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0638 0.0843 0.3075
Echinococcus multilocularis thioredoxin glutathione reductase 0.0093 0.0106 0.0271
Toxoplasma gondii calmodulin CAM1 0.0184 0.0229 0.2315
Giardia lamblia Programmed cell death protein-like protein 0.005 0.0047 0.0427
Brugia malayi Calcium binding EGF domain containing protein 0.0052 0.005 0.0138
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0067 1
Toxoplasma gondii EF hand domain-containing protein 0.005 0.0047 0.042
Echinococcus granulosus calcyphosin protein 0.005 0.0047 0.0122
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.2894 0.389 0.389
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0749 0.0993 0.3625
Trypanosoma brucei META domain/Domain of unknown function (DUF1935), putative 0.0205 0.0257 0.1348
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0029 0.026
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0048 0.0221
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0008 0.0023
Loa Loa (eye worm) hypothetical protein 0.0036 0.0029 0.0079
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0008 0.0008
Trypanosoma cruzi cysteine proteinase, putative 0.0302 0.0389 0.1406
Loa Loa (eye worm) TK/ROR protein kinase 0.0022 0.0009 0.0026
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2033 0.2727 0.2727
Echinococcus multilocularis sarcoplasmic calcium binding protein 0.018 0.0224 0.0575
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0006 0.0017
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0029 0.0083
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0532 0.0699 0.7228
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0146 0.0177 0.0486
Giardia lamblia Cathepsin L precursor 0.0146 0.0177 0.1782
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.022 0.225
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0146 0.0177 0.1126
Trypanosoma cruzi mitochondrial calcium uptake 1, putative 0.018 0.0224 0.08
Trichomonas vaginalis myosin light chain 1, putative 0.018 0.0224 0.2289
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0067 0.0067
Brugia malayi hypothetical protein 0.0041 0.0036 0.0099
Trichomonas vaginalis calmodulin, putative 0.005 0.0047 0.0452
Trichomonas vaginalis glucosylceramidase, putative 0.0271 0.0346 0.3557
Trypanosoma cruzi metacaspase 5, putative 0.0045 0.0041 0.0126
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0146 0.0177 0.1804
Plasmodium vivax vivapain-2 0.0532 0.0699 0.4579
Echinococcus granulosus neuropeptide receptor A26 0.0497 0.0652 0.1673
Schistosoma mansoni calmodulin 0.018 0.0224 0.0224
Brugia malayi calcium-binding protein 0.018 0.0224 0.0615
Trypanosoma brucei metacaspase MCA3 0.0045 0.0041 0.0183
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0146 0.0177 0.0486
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0302 0.0389 0.0389
Plasmodium falciparum serine repeat antigen 3 0.0146 0.0177 0.2476
Entamoeba histolytica cysteine protease, putative 0.0302 0.0389 0.4127
Brugia malayi cathepsin F-like cysteine proteinase 0.0146 0.0177 0.0486
Brugia malayi Cathepsin L-like precursor 0.0157 0.0192 0.0526
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0235 0.0298 1
Trypanosoma cruzi cysteine peptidase, putative 0.0772 0.1024 0.3739
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0072 0.0713
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0024 0.0012 0.0034
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.03 0.0385 0.1393
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0067 0.0067
Trypanosoma cruzi DNA polymerase eta, putative 0.0045 0.0041 0.0126
Echinococcus granulosus calbindin 32 0.0184 0.0229 0.0588
Trypanosoma cruzi caltractin, putative 0.018 0.0224 0.08
Trypanosoma brucei calmodulin, putative 0.018 0.0224 0.1168
Echinococcus granulosus lamin dm0 0.0055 0.0055 0.0141
Plasmodium falciparum thioredoxin reductase 0.0093 0.0106 0.1443
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0008 0.0008
Onchocerca volvulus Myosin regulatory light chain 2 homolog 0.005 0.0047 0.0224
Echinococcus multilocularis transmembrane protease serine 3 0.0041 0.0036 0.0092
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0045 0.0041 0.0111
Schistosoma mansoni cercarial elastase (S01 family) 0.0041 0.0036 0.0036
Giardia lamblia Cathepsin L precursor 0.0146 0.0177 0.1782
Brugia malayi cathepsin L-like precursor 0.0375 0.0488 0.1337
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0302 0.0389 0.0389
Loa Loa (eye worm) hypothetical protein 0.0433 0.0566 0.1552
Leishmania major calmodulin, putative 0.018 0.0224 0.1168
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0235 0.0298 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0022 0.0022
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0041 0.0036 0.0092
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0032 0.0024 0.0599
Trichomonas vaginalis conserved hypothetical protein 0.0146 0.0177 0.1804
Onchocerca volvulus 0.0184 0.0229 0.1086
Onchocerca volvulus 0.0036 0.0029 0.0136
Echinococcus granulosus EF HAND 1 calcium binding site 0.018 0.0224 0.0575
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.018 0.0224 0.2349
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0117 0.0139 0.0356
Onchocerca volvulus 0.0042 0.0037 0.0176
Plasmodium vivax serine-repeat antigen (SERA) 0.0146 0.0177 0.1126
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0008 0.0021
Trichomonas vaginalis calcineurin B subunit, putative 0.018 0.0224 0.2289
Trypanosoma cruzi metacaspase, putative 0.0045 0.0041 0.0126
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0007 0.0008
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0041 0.0381
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0532 0.0699 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.001 0.0022
Brugia malayi Probable myosin regulatory light chain 0.0053 0.0052 0.0144
Schistosoma mansoni calpain-7 (C02 family) 0.1142 0.1523 0.1523
Plasmodium falciparum serine repeat antigen 4 0.0146 0.0177 0.2476
Giardia lamblia Cathepsin B precursor 0.073 0.0966 1
Trypanosoma brucei I/6 autoantigen 0.018 0.0224 0.1168
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0772 0.1024 0.5458
Entamoeba histolytica calpain family cysteine protease, putative 0.0433 0.0566 0.6036
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0693 0.0917 0.4887
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0013 0.01
Brugia malayi RasGEF domain containing protein 0.005 0.0047 0.013
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.03 0.0385 0.1393
Echinococcus granulosus intermediate filament protein 0.0055 0.0055 0.0141
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0008 0.0023
Brugia malayi Neuronal calcium sensor family protein 1 0.005 0.0047 0.013
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0008 0.0039
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0002 0.0004
Trypanosoma brucei Domain of unknown function (DUF1935), putative 0.0205 0.0257 0.1348
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0041 0.0036 0.0036
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0302 0.0389 0.2053
Trichomonas vaginalis set domain proteins, putative 0.0237 0.0301 0.3086
Echinococcus multilocularis calcyphosin protein 0.005 0.0047 0.0122
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0006 0.0026
Leishmania major cathepsin L-like protease 0.0532 0.0699 0.3718
Onchocerca volvulus Mitochondrial Rho GTPase homolog 0.005 0.0047 0.0224
Trichomonas vaginalis conserved hypothetical protein 0.018 0.0224 0.2289
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0032 0.0292
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0558 0.0735 0.2677
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0007 0.0123
Loa Loa (eye worm) hypothetical protein 0.0041 0.0036 0.0099
Echinococcus granulosus calumenin 0.0184 0.0229 0.0588
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0532 0.0699 0.7228
Brugia malayi Cathepsin L-like precursor 0.0375 0.0488 0.1337
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.018 0.0224 0.1436
Echinococcus granulosus programmed cell death protein 0.023 0.0291 0.0747
Trypanosoma cruzi hypothetical protein, conserved 0.0205 0.0257 0.0923
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0009 0.0055
Echinococcus granulosus Calcium binding protein 0.005 0.0047 0.0122
Trypanosoma cruzi calmodulin, putative 0.018 0.0224 0.08
Loa Loa (eye worm) hypothetical protein 0.0101 0.0117 0.032
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0006 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0008 0.0023
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0638 0.0843 0.4489
Leishmania major centrin, putative 0.018 0.0224 0.1168
Schistosoma mansoni hypothetical protein 0.0032 0.0024 0.0024
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.0105 0.0288
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0638 0.0843 0.3075
Echinococcus granulosus centrin 2 0.018 0.0224 0.0575
Plasmodium vivax serine-repeat antigen (SERA) 0.0146 0.0177 0.1126
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0146 0.0177 0.0486
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.001 0.0022
Giardia lamblia Cathepsin L precursor 0.0146 0.0177 0.1782
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0638 0.0843 0.3075
Loa Loa (eye worm) hypothetical protein 0.0026 0.0015 0.0041
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0041 0.0036 0.0036
Onchocerca volvulus 0.0532 0.0699 0.3317
Loa Loa (eye worm) myosin Light Chain family member 0.0053 0.0052 0.0144
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0041 0.0036 0.0036
Onchocerca volvulus 0.1575 0.2108 1
Echinococcus granulosus bloom syndrome protein 0.0021 0.0009 0.0023
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.002 0.0056
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0045 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0146 0.0177 0.0486
Trypanosoma brucei DNA polymerase eta, putative 0.0045 0.0041 0.0184
Giardia lamblia Cathepsin B precursor 0.0146 0.0177 0.1782
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0006 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0302 0.0389 0.4003
Brugia malayi cathepsin L precursor 0.0146 0.0177 0.0486
Brugia malayi Trypsin family protein 0.0041 0.0036 0.0099
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0041 0.0381
Onchocerca volvulus 0.0532 0.0699 0.3317
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0014 0.0101
Echinococcus granulosus calpain A 0.2898 0.3895 1
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0638 0.0843 0.3075
Plasmodium vivax thioredoxin reductase, putative 0.0093 0.0106 0.0652
Trypanosoma brucei calpain, putative 0.0433 0.0566 0.3002
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0006 0.0016
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0433 0.0566 0.5827
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0007 0.0003
Leishmania major hypothetical protein, conserved 0.0205 0.0257 0.1348
Loa Loa (eye worm) hypothetical protein 0.0041 0.0035 0.0097
Onchocerca volvulus 0.0532 0.0699 0.3317
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0772 0.1024 0.5458
Leishmania major cathepsin L-like protease 0.0532 0.0699 0.3718
Trypanosoma brucei cysteine peptidase C (CPC) 0.073 0.0966 0.5149
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0032 0.0151
Schistosoma mansoni myosin light chain 0.005 0.0047 0.0047
Brugia malayi EF hand family protein 0.018 0.0224 0.0615
Brugia malayi cathepsin B-like cysteine proteinase 0.2033 0.2727 0.7479
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.1399 0.187 0.685
Echinococcus multilocularis cysteine protease 0.0532 0.0699 0.1795
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.0233 0.2384
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0693 0.0917 0.4887
Trypanosoma brucei cysteine peptidase, putative 0.0638 0.0843 0.4489
Onchocerca volvulus Cathepsin L homolog 0.0146 0.0177 0.0841
Trypanosoma cruzi major cysteine proteinase, putative 0.0386 0.0502 0.182
Onchocerca volvulus 0.0041 0.0036 0.017
Brugia malayi MH2 domain containing protein 0.0125 0.0149 0.041
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0013
Trichomonas vaginalis glucosylceramidase, putative 0.0271 0.0346 0.3557
Loa Loa (eye worm) hypothetical protein 0.0316 0.0407 0.1117
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0974 0.1297 0.6925
Echinococcus multilocularis chromobox protein 1 0.0068 0.0072 0.0186
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.026 0.0332 0.1745
Echinococcus multilocularis calmodulin 0.018 0.0224 0.0575
Brugia malayi Cathepsin L-like cysteine proteinase 0.0375 0.0488 0.1337
Loa Loa (eye worm) hypothetical protein 0.0375 0.0488 0.1337
Loa Loa (eye worm) hypothetical protein 0.0041 0.0036 0.0099
Echinococcus multilocularis lamin 0.0055 0.0055 0.0141
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0008 0.0008
Trypanosoma brucei Small kinetoplastid calpain-related protein 1-4 0.0205 0.0257 0.1348
Schistosoma mansoni cathepsin s 0.0157 0.0192 0.0192
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0041 0.0381
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.1139 0.1519 0.8115
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0974 0.1297 0.4743
Trypanosoma cruzi cysteine peptidase, putative 0.0772 0.1024 0.3739
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0146 0.0177 0.1804
Echinococcus multilocularis calpain 7 (C02 family) 0.1139 0.1519 0.3899
Trichomonas vaginalis glutathione reductase, putative 0.0032 0.0024 0.0208
Schistosoma mansoni caspase-3 (C14 family) 0.0117 0.0139 0.0139
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0009 0.0023
Mycobacterium tuberculosis Conserved protein 0.0036 0.0029 0.077
Loa Loa (eye worm) hypothetical protein 0.005 0.0047 0.013
Schistosoma mansoni hypothetical protein 0.043 0.0561 0.0561
Schistosoma mansoni neuronal calcium sensor 0.018 0.0224 0.0224
Trypanosoma brucei calpain-like protein, putative 0.1139 0.1519 0.8115
Leishmania major hypothetical protein, conserved 0.0022 0.0009 0.0017
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.0117 0.032
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0014 0.0101
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0032 0.0024 0.2899
Plasmodium vivax unspecified product 0.0146 0.0177 0.1126
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0157 0.0192 0.0526
Echinococcus multilocularis calcium uptake protein 1 0.0184 0.0229 0.0588
Entamoeba histolytica cysteine protease, putative 0.0146 0.0177 0.1845
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.1399 0.187 1
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.022 0.225
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0205 0.0257 0.0923
Leishmania major hypothetical protein, conserved 0.0332 0.0429 0.227
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.026 0.0332 0.1745
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0873 0.116 0.6189
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0146 0.0177 0.1126
Giardia lamblia Cathepsin L-like protease 0.0146 0.0177 0.1782
Trypanosoma cruzi hypothetical protein, conserved 0.005 0.0047 0.0151
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0045 0.0041 0.0349
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0007 0.0021
Entamoeba histolytica cysteine protease, putative 0.0302 0.0389 0.4127
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0146 0.0177 0.1126
Leishmania major cathepsin L-like protease 0.0532 0.0699 0.3718
Loa Loa (eye worm) trypsin family protein 0.0041 0.0036 0.0099
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0146 0.0177 0.1782
Brugia malayi calpain family protein 1 0.2714 0.3646 1
Trypanosoma cruzi hypothetical protein, conserved 0.0205 0.0257 0.0923
Onchocerca volvulus 0.0532 0.0699 0.3317
Entamoeba histolytica Ran family GTPase 0.0022 0.001 0.0044
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.03 0.0385 0.2034
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0433 0.0566 0.3002
Trypanosoma brucei hypothetical protein, conserved 0.0332 0.0429 0.227
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0008 0.0039
Entamoeba histolytica hypothetical protein 0.0025 0.0013 0.0077
Schistosoma mansoni cercarial elastase (S01 family) 0.0041 0.0036 0.0036
Toxoplasma gondii EFHC1, putative 0.018 0.0224 0.2263
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.073 0.0966 1
Echinococcus multilocularis EF HAND 1, calcium binding site 0.018 0.0224 0.0575
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0008 0.0023
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0558 0.0734 0.2674
Loa Loa (eye worm) RecQ helicase 0.0021 0.0009 0.0025
Trichomonas vaginalis calmodulin, putative 0.018 0.0224 0.2289
Trypanosoma cruzi calpain cysteine peptidase, putative 0.1399 0.187 0.685
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0105 0.027
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0008 0.0023
Brugia malayi Myosin regulatory light chain 1 0.005 0.0047 0.013
Plasmodium vivax hypothetical protein, conserved 0.0045 0.0041 0.0221
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative 0.018 0.0224 0.1168
Plasmodium falciparum calpain 0.0433 0.0566 0.8077
Trichomonas vaginalis calpain, putative 0.0433 0.0566 0.5842
Echinococcus multilocularis neurocalcin 0.018 0.0224 0.0575
Brugia malayi Trypsin family protein 0.0041 0.0036 0.0099
Leishmania major protein kinase, putative 0.018 0.0224 0.1168
Brugia malayi Cathepsin L-like precursor 0.0532 0.0699 0.1918
Brugia malayi Trypsin family protein 0.0041 0.0036 0.0099
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0032 0.0024 0.2899
Trichomonas vaginalis centrin, putative 0.005 0.0047 0.0452
Echinococcus multilocularis neuropeptide receptor A26 0.0497 0.0652 0.1673
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0029 0.026
Schistosoma mansoni cathepsin F (C01 family) 0.0532 0.0699 0.0699
Entamoeba histolytica grainin 2 0.023 0.0291 0.3072
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0024 0.0094
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0007 0.0025
Trypanosoma cruzi centrin, putative 0.023 0.0291 0.1046
Schistosoma mansoni hypothetical protein 0.0323 0.0416 0.0416
Entamoeba histolytica calcium binding family protein 0.018 0.0224 0.2349
Schistosoma mansoni DNA polymerase eta 0.0045 0.0041 0.0041
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0532 0.0699 0.7228
Echinococcus multilocularis calpain 5 0.1139 0.1519 0.3899
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0048 0.0605
Entamoeba histolytica cysteine protease, putative 0.0302 0.0389 0.4127
Echinococcus granulosus cathepsin L 0.0302 0.0389 0.0999
Giardia lamblia Cathepsin B precursor 0.0146 0.0177 0.1782
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0146 0.0177 0.1804
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0772 0.1024 0.5458
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0772 0.1024 0.5458
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0041 0.0381
Schistosoma mansoni intermediate filament proteins 0.0055 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0042 0.0037 0.0102
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0146 0.0177 0.1845
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0302 0.0389 0.0389
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.0072 0.0199
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0008 0.0021
Giardia lamblia Hypothetical protein 0.0184 0.0229 0.2321
Loa Loa (eye worm) hypothetical protein 0.0032 0.0024 0.0065
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.001 0.0015
Brugia malayi Cathepsin L-like precursor 0.0532 0.0699 0.1918
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.001 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0008 0.0023
Leishmania major metacaspase, putative 0.0045 0.0041 0.0183
Onchocerca volvulus 0.003 0.0021 0.0098
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0532 0.0699 0.7228
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0146 0.0177 0.1804
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0008 0.0008
Brugia malayi nuclear hormone receptor 0.0021 0.0008 0.0023
Schistosoma mansoni caspase-7 (C14 family) 0.0117 0.0139 0.0139
Giardia lamblia Calmodulin 0.005 0.0047 0.0427
Loa Loa (eye worm) hypothetical protein 0.0146 0.0177 0.0486
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.002 0.0056
Loa Loa (eye worm) hypothetical protein 0.018 0.0224 0.0615
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.2894 0.389 0.9987
Loa Loa (eye worm) hypothetical protein 0.0157 0.0192 0.0526
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0184 0.0229 0.0819
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0007 0.0019
Echinococcus granulosus cathepsin b 0.2033 0.2727 0.7001
Trypanosoma brucei mitochondrial calcium uptake 1 0.018 0.0224 0.1168
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.1326 0.1772 0.9474
Giardia lamblia Cysteine protease 0.0146 0.0177 0.1782
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0375 0.0488 0.5029
Trypanosoma brucei kinesin, putative 0.0705 0.0933 0.4974
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0532 0.0699 0.7228
Echinococcus multilocularis cathepsin L cysteine protease 0.0532 0.0699 0.1795
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0021 0.008
Trypanosoma cruzi kinesin, putative 0.0705 0.0933 0.3407
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0532 0.0699 0.7228
Echinococcus multilocularis thyroid hormone receptor alpha 0.0146 0.0178 0.0456
Brugia malayi beta-lactamase family protein 0.0036 0.0029 0.0079
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0235 0.0298 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0008 0.0008
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0029 0.077
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0271 0.0346 0.0949
Trichomonas vaginalis calcium binding protein, putative 0.023 0.0291 0.2986
Schistosoma mansoni neuronal calcium sensor 0.018 0.0224 0.0224
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0029 0.077
Echinococcus multilocularis cathepsin L 0.0146 0.0177 0.0455
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0016 0.0042
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0006 0.0016
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0029 0.077
Entamoeba histolytica grainin, putative 0.0184 0.0229 0.2403
Schistosoma mansoni hypothetical protein 0.0022 0.0009 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0008 0.0023
Echinococcus multilocularis snurportin 1 0.0323 0.0416 0.1069
Loa Loa (eye worm) hypothetical protein 0.0045 0.0041 0.0111
Plasmodium falciparum metacaspase-like protein 0.0045 0.0041 0.0503
Echinococcus granulosus calpain 5 0.1139 0.1519 0.3899
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0041 0.0381
Trypanosoma brucei hypothetical protein 0.0693 0.0917 0.4887
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0532 0.0699 0.7228
Schistosoma mansoni cercarial elastase (S01 family) 0.0041 0.0036 0.0036
Trypanosoma cruzi metacaspase 5, putative 0.0045 0.0041 0.0126
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0041 0.0381
Giardia lamblia Cysteine protease 0.0146 0.0177 0.1782
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.1399 0.187 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0032 0.0024 0.0263
Mycobacterium tuberculosis Probable dehydrogenase 0.0212 0.0266 0.8907
Toxoplasma gondii calcium binding protein precursor, putative 0.005 0.0047 0.042
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0029 0.077
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0021 0.0147
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0532 0.0699 0.7228
Trypanosoma brucei metacaspase 0.0045 0.0041 0.0183
Trypanosoma cruzi conserved protein 0.0647 0.0855 0.3119
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0008 0.0008
Trypanosoma brucei META domain/Domain of unknown function (DUF1935), putative 0.0205 0.0257 0.1348
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0045 0.0041 0.0349
Loa Loa (eye worm) transcription factor SMAD2 0.0125 0.0149 0.041
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0146 0.0177 0.1782
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0146 0.0177 0.1804
Trypanosoma cruzi cysteine peptidase, putative 0.0302 0.0389 0.1406
Loa Loa (eye worm) DEAH box polypeptide 35 0.0035 0.0027 0.0074
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0055 0.0055 0.0151
Onchocerca volvulus 0.0375 0.0488 0.2313
Trypanosoma cruzi programmed cell death 6 protein-like, putative 0.018 0.0224 0.08
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0302 0.0389 0.1406
Entamoeba histolytica calmodulin, putative 0.005 0.0047 0.0442
Echinococcus multilocularis calmodulin 0.018 0.0224 0.0575
Echinococcus granulosus cathepsin L 0.0146 0.0177 0.0455
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0024 0.0064
Echinococcus granulosus caspase 8 0.0045 0.0041 0.0104
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0041 0.0381
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0008 0.0008
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0008 0.0021
Onchocerca volvulus Cell death protein 3 homolog 0.0086 0.0097 0.046
Entamoeba histolytica cysteine proteinase 2 0.0302 0.0389 0.4127
Trichomonas vaginalis calmodulin-2, putative 0.018 0.0224 0.2289
Echinococcus granulosus tissue type plasminogen activator 0.0022 0.0009 0.0024
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0007 0.0017
Plasmodium falciparum thioredoxin reductase 0.0032 0.0024 0.0263
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0212 0.0266 0.8907
Loa Loa (eye worm) hypothetical protein 0.005 0.0048 0.013
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0008 0.0008
Echinococcus granulosus chromobox protein 1 0.0068 0.0072 0.0186
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0024 0.0064
Entamoeba histolytica cysteine protease, putative 0.0146 0.0177 0.1845
Giardia lamblia Cathepsin B precursor 0.0146 0.0177 0.1782
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.2894 0.389 0.389
Echinococcus multilocularis caspase 3 0.0073 0.0078 0.0201
Brugia malayi follicle stimulating hormone receptor 0.0256 0.0326 0.0894
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0008 0.0023
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0008 0.0021
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0007 0.0018
Trichomonas vaginalis esterase, putative 0.0036 0.0029 0.026
Loa Loa (eye worm) hypothetical protein 0.0035 0.0027 0.0074
Plasmodium falciparum serine repeat antigen 9 0.0146 0.0177 0.2476
Schistosoma mansoni Mername-AA248 (C02 family) 0.1139 0.1519 0.1519
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0029 0.026
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.001 0.0043
Loa Loa (eye worm) hypothetical protein 0.2008 0.2693 0.7387
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0016 0.0042
Leishmania major small myristoylated protein 4, putative 0.0558 0.0734 0.3904
Loa Loa (eye worm) calpain D 0.0433 0.0566 0.1552
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.026 0.0332 0.1196
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0007 0.0004
Echinococcus multilocularis calbindin 32 0.0184 0.0229 0.0588
Onchocerca volvulus 0.0237 0.0301 0.1427
Schistosoma mansoni cercarial elastase (S01 family) 0.0041 0.0036 0.0036
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0616 0.0812 0.2961
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0032 0.0024 0.0094
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0032 0.0024 0.0061
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0011 0.0027
Trypanosoma cruzi small myristoylated protein 1-1 0.0354 0.0458 0.1662
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0029 0.0029
Onchocerca volvulus Arrow homolog 0.0026 0.0016 0.0075
Toxoplasma gondii EF hand domain-containing protein 0.018 0.0224 0.2263
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0532 0.0699 0.7228
Giardia lamblia Cysteine protease 0.0146 0.0177 0.1782
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0074 0.0202
Loa Loa (eye worm) hypothetical protein 0.0086 0.0097 0.0267
Schistosoma mansoni reticulocalbin 0.0184 0.0229 0.0229
Entamoeba histolytica hypothetical protein, conserved 0.0184 0.0229 0.2403
Schistosoma mansoni calmodulin 0.018 0.0224 0.0224
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.022 0.225
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0048 0.0152
Loa Loa (eye worm) cathepsin B 0.073 0.0966 0.2649
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0073 0.0079 0.0204
Onchocerca volvulus 0.0041 0.0036 0.017
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0041 0.0036 0.0036
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.001 0.0027
Trichomonas vaginalis glucosylceramidase, putative 0.0271 0.0346 0.3557
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0008 0.0021
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0007 0.0034
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.018 0.0224 0.08
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0021 0.008
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0621 0.0819 0.4361
Loa Loa (eye worm) hypothetical protein 0.003 0.0021 0.0058
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0532 0.0699 0.7228
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0212 0.0266 0.8816
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0041 0.0381
Plasmodium falciparum importin beta, putative 0.003 0.0021 0.0225
Echinococcus granulosus calcium uptake protein 1 0.0184 0.0229 0.0588
Loa Loa (eye worm) hypothetical protein 0.018 0.0224 0.0615
Trichomonas vaginalis conserved hypothetical protein 0.018 0.0224 0.2289
Echinococcus multilocularis apoptotic protease activating factor 1 0.0042 0.0037 0.0095
Trichomonas vaginalis mercuric reductase, putative 0.0032 0.0024 0.0208
Trypanosoma cruzi I/6 autoantigen, putative 0.018 0.0224 0.08
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0008 0.0021
Entamoeba histolytica cysteine protease, putative 0.0146 0.0177 0.1845
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0146 0.0177 0.0177
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0008 0.0023
Trichomonas vaginalis ran, putative 0.0022 0.001 0.0069
Brugia malayi cathepsin Z-like cysteine proteinase 0.0146 0.0177 0.0486
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.001 0.0035
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0026 0.0016 0.0044
Brugia malayi hypothetical protein 0.005 0.0048 0.013
Trypanosoma brucei centrin, putative 0.018 0.0224 0.1168
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0041 0.0381
Loa Loa (eye worm) hypothetical protein 0.0054 0.0054 0.0147
Trypanosoma brucei small myristoylated protein 1-1 0.0354 0.0458 0.2426
Brugia malayi Kringle domain containing protein 0.0022 0.0009 0.0026
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0006 0.0017
Schistosoma mansoni cpg binding protein 0.0063 0.0065 0.0065
Trypanosoma cruzi cysteine peptidase, putative 0.0532 0.0699 0.2547
Schistosoma mansoni caspase-7 (C14 family) 0.0086 0.0097 0.0097
Leishmania major small myristoylated protein-2 0.0645 0.0851 0.4535
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0013 0.01
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0029 0.3729
Trypanosoma cruzi small myristoylated protein 1-2 0.0354 0.0458 0.1662
Loa Loa (eye worm) hypothetical protein 0.0157 0.0192 0.0526
Leishmania major calmodulin-like protein 0.018 0.0224 0.1168
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0029 0.0079
Toxoplasma gondii cathepsin CPC1 0.0146 0.0177 0.1776
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0008 0.0023
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0006 0.0006
Brugia malayi Cathepsin L-like precursor 0.0532 0.0699 0.1918
Echinococcus multilocularis Mastin 0.0041 0.0036 0.0092
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0117 0.0139 0.0356
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.026 0.0332 0.1745
Plasmodium falciparum centrin-4 0.005 0.0047 0.0602
Trypanosoma cruzi I/6 autoantigen, putative 0.018 0.0224 0.08
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0974 0.1297 0.6925
Echinococcus granulosus neurocalcin 0.018 0.0224 0.0575
Plasmodium falciparum serine repeat antigen 2 0.0146 0.0177 0.2476
Echinococcus granulosus calpain A 0.1139 0.1519 0.3899
Loa Loa (eye worm) hypothetical protein 0.0146 0.0177 0.0486
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0045 0.0041 0.0041
Onchocerca volvulus 0.0052 0.005 0.0237
Plasmodium vivax metacaspase 1, putative 0.0045 0.0041 0.0221
Schistosoma mansoni rab 0.018 0.0224 0.0224
Trichomonas vaginalis centrin, putative 0.018 0.0224 0.2289
Leishmania major importin beta-1 subunit, putative 0.0025 0.0013 0.0038
Giardia lamblia Cathepsin B precursor 0.073 0.0966 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0032 0.0024 0.0094
Schistosoma mansoni calpain-7 (C02 family) 0.1142 0.1523 0.1523
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0024 0.006
Toxoplasma gondii calcium-dependent protein kinase 0.0184 0.0229 0.2315
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0157 0.0192 0.0526
Trypanosoma cruzi hypothetical protein, conserved 0.0332 0.0429 0.1555
Brugia malayi calpain 5 0.0705 0.0933 0.2559
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.026 0.0332 0.1745
Brugia malayi calpain 5 0.0433 0.0566 0.1552
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0873 0.116 0.6189
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0008 0.0023
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0023
Schistosoma mansoni hypothetical protein 0.0125 0.015 0.015
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0008 0.0021
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0932 0.1239 0.6614
Schistosoma mansoni cercarial elastase (S01 family) 0.0041 0.0036 0.0036
Mycobacterium tuberculosis Conserved protein 0.0036 0.0029 0.077
Loa Loa (eye worm) hypothetical protein 0.0146 0.0177 0.0486
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0008 0.0023
Echinococcus granulosus caspase 2 0.0086 0.0097 0.0249
Loa Loa (eye worm) hypothetical protein 0.0038 0.0032 0.0088
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.1326 0.1772 0.6489
Echinococcus multilocularis EF hand domain containing family member A2 0.018 0.0224 0.0575
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0041 0.0036 0.0036
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.2033 0.2727 0.2727
Onchocerca volvulus Cathepsin F homolog 0.0532 0.0699 0.3317
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0008 0.0039
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.0067 0.0171
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0638 0.0843 0.3075
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0105 0.0105
Plasmodium vivax glutathione reductase, putative 0.0093 0.0106 0.0652
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0007 0.0004
Loa Loa (eye worm) EF hand family protein 0.018 0.0224 0.0615
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0974 0.1297 0.4743
Loa Loa (eye worm) ctsf protein 0.0532 0.0699 0.1918
Leishmania major cathepsin L-like protease 0.0772 0.1024 0.5458
Loa Loa (eye worm) hypothetical protein 0.0041 0.0036 0.0099
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0146 0.0177 0.1782
Loa Loa (eye worm) hypothetical protein 0.0045 0.0041 0.0111
Leishmania major centrin, putative 0.018 0.0224 0.1168
Onchocerca volvulus 0.0022 0.0009 0.0044
Entamoeba histolytica cysteine protease, putative 0.0302 0.0389 0.4127
Plasmodium falciparum serine repeat antigen 5 0.0146 0.0177 0.2476
Echinococcus granulosus calpain 0.1139 0.1519 0.3899
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0013 0.01
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0146 0.0177 0.0177
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0024 0.006
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0105 0.027
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.018 0.0224 0.2349
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0105 0.027
Trichomonas vaginalis DNA-dependent protein kinase catalytic subunit-interacting protein, putative 0.018 0.0224 0.2289
Trypanosoma brucei antigen, putative 0.1139 0.1519 0.8115
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0621 0.0819 0.2987
Plasmodium falciparum metacaspase 1 0.0045 0.0041 0.0503
Plasmodium vivax vivapain-3 0.0302 0.0389 0.2526
Brugia malayi Importin beta-1 subunit 0.003 0.0021 0.0058
Trypanosoma cruzi cruzipain precursor, putative 0.0772 0.1024 0.3739
Loa Loa (eye worm) hypothetical protein 0.0015 0 0.0001
Loa Loa (eye worm) calpain family protein 1 0.2714 0.3646 1
Schistosoma mansoni neuronal calcium sensor 0.018 0.0224 0.0224
Trichomonas vaginalis calmodulin, putative 0.018 0.0224 0.2289
Trypanosoma cruzi centrin, putative 0.023 0.0291 0.1046
Toxoplasma gondii hypothetical protein 0.0433 0.0566 0.5827
Loa Loa (eye worm) myosin regulatory light chain 1 0.005 0.0047 0.013
Loa Loa (eye worm) hypothetical protein 0.005 0.0047 0.013
Entamoeba histolytica calcium-binding protein, putative 0.018 0.0224 0.2349
Loa Loa (eye worm) CXXC zinc finger family protein 0.0059 0.006 0.0165
Trichomonas vaginalis calcium binding protein, putative 0.005 0.0047 0.0452
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0024 0.0064
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0008 0.0021
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0072 0.0713
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2033 0.2727 0.2727
Echinococcus multilocularis programmed cell death protein 0.023 0.0291 0.0747
Leishmania major hypothetical protein, conserved 0.0647 0.0855 0.4553
Schistosoma mansoni Sarcoplasmic calcium-binding protein (SCP). 0.018 0.0224 0.0224
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0749 0.0993 0.5292
Plasmodium vivax importin-beta 2, putative 0.003 0.0021 0.0093
Echinococcus multilocularis dnaJ subfamily B 0.043 0.0561 0.1441
Trichomonas vaginalis calmodulin, putative 0.0184 0.0229 0.2341
Onchocerca volvulus 0.0055 0.0055 0.026
Leishmania major DNA polymerase eta, putative 0.0031 0.0023 0.0088
Brugia malayi calpain 7 0.1139 0.1519 0.4165
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0008 0.0021
Loa Loa (eye worm) fibroinase 0.0532 0.0699 0.1918
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0772 0.1024 0.5458
Loa Loa (eye worm) hypothetical protein 0.228 0.3061 0.8394
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.0067 0.0323
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0146 0.0177 0.1804
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0029 0.077
Onchocerca volvulus Cathepsin L homolog 0.0532 0.0699 0.3317
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0014 0.0101
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0932 0.1239 0.6614
Schistosoma mansoni coup transcription factor 0.0021 0.0008 0.0008
Echinococcus granulosus Myosin regulatory light chain 0.005 0.0047 0.0122
Leishmania major centrin, putative,caltractin, putative 0.018 0.0224 0.1168
Brugia malayi hypothetical protein 0.0121 0.0144 0.0395
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0032 0.0024 0.0024
Trypanosoma brucei Small kinetoplastid calpain-related protein 1-5 0.0205 0.0257 0.1348
Echinococcus multilocularis Myosin regulatory light chain 0.005 0.0047 0.0122
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0093 0.0106 0.3405
Schistosoma mansoni ap endonuclease 0.002 0.0007 0.0007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0375 0.0488 0.5029
Schistosoma mansoni hypothetical protein 0.018 0.0224 0.0224
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0023
Echinococcus granulosus snurportin 1 0.0323 0.0416 0.1069
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0041 0.0381
Trypanosoma brucei hypothetical protein, conserved 0.018 0.0224 0.1168
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0125 0.015 0.0384
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.073 0.0966 0.0966
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0007 0.0017
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0271 0.0346 0.0949
Schistosoma mansoni chromobox protein 0.0068 0.0072 0.0072
Trichomonas vaginalis glucosylceramidase, putative 0.0271 0.0346 0.3557
Echinococcus granulosus cpg binding protein 0.0063 0.0065 0.0166
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0014 0.0101
Echinococcus multilocularis centrin 2 0.018 0.0224 0.0575
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0146 0.0177 0.0177
Leishmania major small myristoylated protein-1 0.0354 0.0458 0.2426
Treponema pallidum NADH oxidase 0.0032 0.0024 1
Echinococcus multilocularis EF hand domain containing family member A2 0.0184 0.0229 0.0588
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0024 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0032 0.0292
Leishmania major hypothetical protein, conserved 0.005 0.0048 0.0221
Giardia lamblia Encystation-specific protease 0.0146 0.0177 0.1782
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.001 0.007
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.1139 0.1519 0.5559
Echinococcus multilocularis calpain family protein 1, d 0.2008 0.2693 0.6915
Leishmania major cathepsin L-like protease 0.0772 0.1024 0.5458
Plasmodium falciparum serine repeat antigen 7 0.0146 0.0177 0.2476
Plasmodium falciparum glutathione reductase 0.0032 0.0024 0.0263
Schistosoma mansoni importin beta-1 0.003 0.0021 0.0021
Echinococcus granulosus cysteine protease 0.0302 0.0389 0.0999
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0022 0.0057
Brugia malayi ecdysteroid receptor 0.0021 0.0008 0.0023
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0146 0.0177 0.1126
Giardia lamblia Cathepsin L-like protease 0.0146 0.0177 0.1782
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0008 0.0021
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0009 0.0025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0532 0.0699 0.7228
Echinococcus multilocularis musashi 0.0055 0.0055 0.0141
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0023
Leishmania major cysteine peptidase A (CPA) 0.0532 0.0699 0.3718
Echinococcus granulosus transmembrane protease serine 3 0.0041 0.0036 0.0092
Entamoeba histolytica cysteine protease, putative 0.0302 0.0389 0.4127
Trypanosoma cruzi major cysteine proteinase, putative 0.0146 0.0177 0.0629
Echinococcus granulosus dnaJ subfamily B 0.043 0.0561 0.1441
Schistosoma mansoni hypothetical protein 0.0032 0.0024 0.0024
Onchocerca volvulus 0.018 0.0224 0.1062
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0009 0.0012
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0032 0.0024 0.0094
Echinococcus granulosus caspase 0.0117 0.0139 0.0356
Onchocerca volvulus 0.0146 0.0177 0.0841
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0024 0.0094
Brugia malayi Cell death protein 3 precursor 0.0086 0.0097 0.0267
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0127 0.0151 0.0151
Schistosoma mansoni hypothetical protein 0.0022 0.0011 0.0011
Brugia malayi fibroinase precursor 0.0146 0.0177 0.0486
Mycobacterium tuberculosis Probable oxidoreductase 0.0235 0.0298 1
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0146 0.0177 0.1126
Trichomonas vaginalis glucosylceramidase, putative 0.0271 0.0346 0.3557
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0014 0.0101
Schistosoma mansoni hypothetical protein 0.0334 0.0432 0.0432
Echinococcus granulosus glycoprotein Antigen 5 0.0041 0.0036 0.0092
Leishmania major hypothetical protein, conserved 0.0205 0.0257 0.1348
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0146 0.0177 0.2476
Echinococcus multilocularis cpg binding protein 0.0063 0.0065 0.0166
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0008 0.0021
Schistosoma mansoni hypothetical protein 0.0433 0.0566 0.0566
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0029 0.0029
Giardia lamblia Hypothetical protein 0.0146 0.0177 0.1782
Leishmania major programmed cell death 6 protein-like protein 0.018 0.0224 0.1168
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0032 0.0024 0.0065
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0024 0.0012 0.0034
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0008 0.0023
Schistosoma mansoni reticulocalbin 0.018 0.0224 0.0224
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0023 0.006
Plasmodium vivax vivapain-1 0.0302 0.0389 0.2526
Trypanosoma cruzi cruzipain precursor, putative 0.0157 0.0192 0.0682
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0024 0.0065
Loa Loa (eye worm) hypothetical protein 0.0055 0.0055 0.0151
Giardia lamblia Cathepsin B precursor 0.073 0.0966 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0014 0.0101
Loa Loa (eye worm) hypothetical protein 0.0041 0.0036 0.0099
Trypanosoma brucei Metacaspase-4 0.0045 0.0041 0.0183
Giardia lamblia Cathepsin B precursor 0.0146 0.0177 0.1782
Loa Loa (eye worm) MH2 domain-containing protein 0.0125 0.0149 0.041
Trypanosoma cruzi calmodulin, putative 0.018 0.0224 0.08
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0433 0.0566 0.5842
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.0067 0.0171
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1139 0.1519 0.5559
Loa Loa (eye worm) hypothetical protein 0.0375 0.0488 0.1337
Loa Loa (eye worm) hypothetical protein 0.0036 0.0029 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.0332 0.0429 0.4423
Leishmania major META domain containing protein 0.0205 0.0257 0.1348
Leishmania major hypothetical protein, conserved 0.0036 0.0029 0.0121
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0017 0.0136
Trichomonas vaginalis conserved hypothetical protein 0.0146 0.0177 0.1804
Echinococcus granulosus caspase 3 0.0073 0.0078 0.0201
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0005 0.0014
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0032 0.0024 0.5
Trichomonas vaginalis hypothetical protein 0.0433 0.0566 0.5842
Trypanosoma cruzi Domain of unknown function (DUF1935), putative 0.0205 0.0257 0.0923
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0532 0.0699 0.7228
Brugia malayi intermediate filament protein 0.0055 0.0055 0.0151
Brugia malayi Thioredoxin reductase 0.0093 0.0106 0.029
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0007 0.0034
Schistosoma mansoni cathepsin S (C01 family) 0.0146 0.0177 0.0177
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1399 0.187 0.685
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.001 0.0029
Schistosoma mansoni lamin 0.0055 0.0055 0.0055
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0146 0.0177 0.1126
Loa Loa (eye worm) thioredoxin reductase 0.0093 0.0106 0.029
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.0024 1
Brugia malayi EF hand family protein 0.0184 0.0229 0.0628
Trichomonas vaginalis glucosylceramidase, putative 0.0271 0.0346 0.3557
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0041 0.0381
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.03 0.0385 0.2034
Brugia malayi cathepsin F-like cysteine proteinase 0.0157 0.0192 0.0526
Brugia malayi Pre-SET motif family protein 0.0031 0.0022 0.0061
Echinococcus granulosus EF hand domain containing family member A2 0.0184 0.0229 0.0588
Entamoeba histolytica cysteine protease, putative 0.0146 0.0177 0.1845
Plasmodium vivax SET domain protein, putative 0.0031 0.0022 0.0101
Entamoeba histolytica cysteine protease, putative 0.0302 0.0389 0.4127
Trichomonas vaginalis centrin, putative 0.005 0.0047 0.0452
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0146 0.0177 0.0177
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0105 0.0105
Echinococcus multilocularis caspase 8 0.0045 0.0041 0.0104
Loa Loa (eye worm) hypothetical protein 0.2714 0.3646 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0022 0.0022
Echinococcus granulosus cathepsin l1 0.0375 0.0488 0.1252
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0532 0.0699 0.1795
Schistosoma mansoni hypothetical protein 0.0041 0.0036 0.0036
Echinococcus multilocularis cathepsin b 0.2033 0.2727 0.7001
Entamoeba histolytica cysteine proteinase, putative 0.0302 0.0389 0.4127
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0008 0.0021
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0638 0.0843 0.3075
Echinococcus multilocularis programmed cell death protein 0.023 0.0291 0.0747
Trichomonas vaginalis Crustacean calcium-binding protein, putative 0.018 0.0224 0.2289
Mycobacterium tuberculosis Probable reductase 0.0212 0.0266 0.8907
Leishmania major trypanothione reductase 0.0093 0.0106 0.0533
Loa Loa (eye worm) hypothetical protein 0.0146 0.0177 0.0486
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0146 0.0177 0.2476
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0009
Trypanosoma brucei Calpain-like protein 1.1 0.0974 0.1297 0.6925
Echinococcus multilocularis neuronal calcium sensor 0.018 0.0224 0.0575
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.026 0.0332 0.1745
Brugia malayi Papain family cysteine protease containing protein 0.0146 0.0177 0.0486
Brugia malayi Probable ATP-dependent helicase DHX35 0.0035 0.0027 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0017 0.0136
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0022 0.0057
Brugia malayi Cathepsin L-like precursor 0.0532 0.0699 0.1918
Entamoeba histolytica cysteine proteinase, putative 0.0302 0.0389 0.4127
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0008 0.0023
Echinococcus multilocularis caspase 2 0.0086 0.0097 0.0249
Trichomonas vaginalis calmodulin, putative 0.018 0.0224 0.2289
Brugia malayi ImpB/MucB/SamB family protein 0.0045 0.0041 0.0111
Entamoeba histolytica cysteine proteinase, putative 0.0532 0.0699 0.7475
Echinococcus granulosus cathepsin L cysteine protease 0.0302 0.0389 0.0999
Leishmania major calmodulin, putative 0.018 0.0224 0.1168
Onchocerca volvulus Cathepsin L homolog 0.0532 0.0699 0.3317
Echinococcus multilocularis caspase 0.0117 0.0139 0.0356
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0146 0.0177 0.1804
Trypanosoma brucei calpain, putative 0.0693 0.0917 0.4887
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0029 0.077
Toxoplasma gondii calmodulin, putative 0.005 0.0047 0.042
Echinococcus granulosus cathepsin b 0.2033 0.2727 0.7001
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0146 0.0177 0.1804
Plasmodium falciparum serine repeat antigen 1 0.0146 0.0177 0.2476
Toxoplasma gondii calmodulin CAM2 0.005 0.0047 0.042
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0014 0.0101
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0024 0.006
Toxoplasma gondii centrin, putative 0.018 0.0224 0.2263
Echinococcus multilocularis cathepsin L 0.0302 0.0389 0.0999
Schistosoma mansoni cercarial elastase (S01 family) 0.0041 0.0036 0.0036
Entamoeba histolytica grainin 2 0.005 0.0047 0.0442
Toxoplasma gondii cathepsin CPL 0.0532 0.0699 0.7219
Schistosoma mansoni calcium binding atopy-related autoantigen 0.0184 0.0229 0.0229
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0023
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0146 0.0177 0.1804
Brugia malayi calpain D 0.0433 0.0566 0.1552
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.022 0.225
Echinococcus granulosus neuronal calcium sensor 0.018 0.0224 0.0575
Echinococcus multilocularis calpain A 0.2898 0.3895 1
Trypanosoma cruzi hypothetical protein, conserved 0.0332 0.0429 0.1555
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0146 0.0177 0.1126
Mycobacterium ulcerans hypothetical protein 0.0036 0.0029 0.3729
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0302 0.0389 0.2053
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0024 0.006
Onchocerca volvulus 0.005 0.0047 0.0224
Loa Loa (eye worm) hypothetical protein 0.0026 0.0015 0.0041
Trypanosoma cruzi metacaspase, putative 0.0045 0.0041 0.0126
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0621 0.0819 0.4361
Giardia lamblia Cathepsin L precursor 0.0146 0.0177 0.1782
Plasmodium vivax centrin-1, putative 0.018 0.0224 0.1436
Brugia malayi Cathepsin L-like precursor 0.0375 0.0488 0.1337
Onchocerca volvulus 0.0021 0.0008 0.0039
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0007 0.0019
Plasmodium falciparum serine repeat antigen 6 0.0146 0.0177 0.2476
Onchocerca volvulus 0.0532 0.0699 0.3317
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0146 0.0177 0.1804
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0019 0.0049
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0007 0.0018
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0041 0.0381
Schistosoma mansoni hypothetical protein 0.0032 0.0024 0.0024
Plasmodium falciparum centrin-1 0.018 0.0224 0.315
Entamoeba histolytica calmodulin, putative 0.018 0.0224 0.2349
Brugia malayi hypothetical protein 0.0042 0.0037 0.0102
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0146 0.0177 0.1126
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0146 0.0177 0.1804
Mycobacterium tuberculosis Conserved protein 0.0036 0.0029 0.077
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0029 0.0144
Trypanosoma brucei centrin-3 0.023 0.0291 0.1528
Echinococcus granulosus GPCR family 2 0.0032 0.0024 0.006
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0024 0.0064
Echinococcus granulosus EF hand domain containing family member A2 0.018 0.0224 0.0575
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0023
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.022 0.225
Echinococcus multilocularis cysteine protease 0.0532 0.0699 0.1795
Echinococcus multilocularis glycoprotein Antigen 5 0.0041 0.0036 0.0092
Loa Loa (eye worm) calpain 5 0.0705 0.0933 0.2559
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0048 0.0152
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.018 0.0224 0.08
Echinococcus granulosus thioredoxin glutathione reductase 0.0093 0.0106 0.0271
Toxoplasma gondii preprocathepsin c precursor, putative 0.0146 0.0177 0.1776
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0763 0.1012 0.5395
Echinococcus granulosus programmed cell death protein 6 0.0053 0.0052 0.0134
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.1326 0.1772 0.6489
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0532 0.0699 0.7228
Echinococcus multilocularis programmed cell death protein 6 0.0053 0.0052 0.0134
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0146 0.0177 0.0177
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0029 0.0121
Loa Loa (eye worm) hypothetical protein 0.0036 0.0029 0.0079
Trypanosoma brucei caltractin, putative 0.023 0.0291 0.1528
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0433 0.0566 0.3002
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0433 0.0566 0.5842
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0008 0.0023
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0041 0.0036 0.0092
Leishmania major DNA polymerase eta, putative 0.0045 0.0041 0.0184
Loa Loa (eye worm) hypothetical protein 0.0146 0.0177 0.0486
Leishmania major calcineurin B subunit, putative 0.018 0.0224 0.1168
Trichomonas vaginalis calmodulin, putative 0.023 0.0291 0.2986
Plasmodium vivax calpain, putative 0.1139 0.1519 1
Leishmania major receptor-type adenylate cyclase a-like protein 0.0205 0.0257 0.1348
Schistosoma mansoni calpain-2 (C02 family) 0.0433 0.0566 0.0566
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.0117 0.032
Entamoeba histolytica cysteine proteinase, putative 0.0302 0.0389 0.4127
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0621 0.0819 0.2987
Brugia malayi RNA, U transporter 1 0.0086 0.0096 0.0265
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.2894 0.389 0.9987
Brugia malayi Pre-SET motif family protein 0.0209 0.0262 0.0719
Entamoeba histolytica cysteine protease, putative 0.0302 0.0389 0.4127
Giardia lamblia Hypothetical protein 0.0146 0.0177 0.1782
Schistosoma mansoni cathepsin C 0.0146 0.0177 0.0177
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0638 0.0843 0.3075
Echinococcus multilocularis calpain 0.1139 0.1519 0.3899
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0229 0.029 0.9714
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0008 0.0023
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0009 0.0055
Schistosoma mansoni thyroid hormone receptor 0.0146 0.0178 0.0178
Leishmania major kinesin, putative 0.0705 0.0933 0.4974
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0323 0.0416 0.1142
Plasmodium vivax myosin A tail domain interacting protein MTIP, putative 0.005 0.0047 0.0266
Giardia lamblia Cysteine protease 0.0146 0.0177 0.1782
Brugia malayi calpain family protein 1 0.2714 0.3646 1
Onchocerca volvulus 0.0532 0.0699 0.3317
Trypanosoma brucei Calpain-like protein CALP1.3 0.0638 0.0843 0.4489
Onchocerca volvulus 0.0055 0.0055 0.026
Schistosoma mansoni hypothetical protein 0.0042 0.0037 0.0037
Brugia malayi Papain family cysteine protease containing protein 0.0302 0.0389 0.1067
Entamoeba histolytica cysteine protease, putative 0.0302 0.0389 0.4127
Echinococcus multilocularis tissue type plasminogen activator 0.0022 0.0009 0.0024
Echinococcus multilocularis dna polymerase eta 0.0045 0.0041 0.0104
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0105 0.0105
Brugia malayi cathepsin L-like cysteine proteinase 0.0146 0.0177 0.0486
Schistosoma mansoni chromobox protein 0.0068 0.0072 0.0072
Trichomonas vaginalis calmodulin, putative 0.018 0.0224 0.2289
Echinococcus granulosus cathepsin l cysteine peptidase 0.0532 0.0699 0.1795
Plasmodium falciparum glutathione reductase 0.0093 0.0106 0.1443
Brugia malayi Cathepsin L-like precursor 0.0532 0.0699 0.1918
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0532 0.0699 0.7228
Entamoeba histolytica cysteine proteinase 1, putative 0.0302 0.0389 0.4127
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0146 0.0177 0.0177
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0008 0.0023
Schistosoma mansoni ran 0.0022 0.001 0.001
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0433 0.0566 0.5842
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0125 0.015 0.0384
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0146 0.0177 0.1804
Schistosoma mansoni centrin-related 0.018 0.0224 0.0224
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0008 0.0023
Echinococcus multilocularis GPCR, family 2 0.0032 0.0024 0.006
Entamoeba histolytica cysteine proteinase, putative 0.0375 0.0488 0.5193
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0032 0.0024 0.0061
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0024 0.0094
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.0067 0.2065
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.03 0.0385 0.1393
Schistosoma mansoni cercarial elastase (S01 family) 0.0041 0.0036 0.0036
Plasmodium vivax unspecified product 0.0157 0.0192 0.1223
Echinococcus granulosus chromobox protein 1 0.0068 0.0072 0.0186
Loa Loa (eye worm) hypothetical protein 0.0022 0.0009 0.0026
Schistosoma mansoni cathepsin F (C01 family) 0.0532 0.0699 0.0699
Loa Loa (eye worm) hypothetical protein 0.2033 0.2727 0.7479
Onchocerca volvulus 0.0042 0.0037 0.0175
Schistosoma mansoni hypothetical protein 0.0334 0.0432 0.0432
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0047 0.0452
Trichomonas vaginalis caltractin, putative 0.005 0.0047 0.0452
Echinococcus granulosus importin subunit beta 1 0.003 0.0021 0.0054
Schistosoma mansoni cercarial elastase (S01 family) 0.0041 0.0036 0.0036
Toxoplasma gondii cathepsin B 0.073 0.0966 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0014 0.0101
Loa Loa (eye worm) hypothetical protein 0.0532 0.0699 0.1918
Loa Loa (eye worm) programmed cell death protein 6 0.0184 0.0229 0.0628
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.073 0.0966 0.3527
Trypanosoma brucei small myristoylated protein 1-2 0.0354 0.0458 0.2426
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0041 0.0036 0.0092

Activities

Activity type Activity value Assay description Source Reference
AUC (ADMET) = 50 ug min ml-1 Total absorption of the compound was estimated by area under curve (AUC) after intravenous administration in rat ChEMBL. 8632421
delta Log P = 4.05 Partition coefficient of the compound was determined by standard shake-flask techniquesat 37 C, using octanol and cyclohexane ChEMBL. 8632421
IC50 (binding) = 0.025 uM Inhibitory activity was evaluated against human Endothelin A receptor ChEMBL. 8632421
IC50 (binding) = 0.025 uM Inhibitory activity was evaluated against human Endothelin A receptor ChEMBL. 8632421
IC50 (binding) > 100 uM Inhibitory activity was evaluated against human Endothelin B receptor ChEMBL. 8632421
IC50 (binding) > 100 uM Inhibitory activity was evaluated against human Endothelin B receptor ChEMBL. 8632421

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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