Detailed information for compound 345639

Basic information

Technical information
  • TDR Targets ID: 345639
  • Name: methyl (E)-3-[3-(2-morpholin-4-yl-4-oxochrome n-8-yl)phenyl]prop-2-enoate
  • MW: 391.417 | Formula: C23H21NO5
  • H donors: 0 H acceptors: 2 LogP: 3.41 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)/C=C/c1cccc(c1)c1cccc2c1oc(cc2=O)N1CCOCC1
  • InChi: 1S/C23H21NO5/c1-27-22(26)9-8-16-4-2-5-17(14-16)18-6-3-7-19-20(25)15-21(29-23(18)19)24-10-12-28-13-11-24/h2-9,14-15H,10-13H2,1H3/b9-8+
  • InChiKey: HPZBCCYHCZUHEU-CMDGGOBGSA-N  


Substructure search Similarity search

Network

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Synonyms

  • methyl (E)-3-[3-(2-morpholino-4-oxo-chromen-8-yl)phenyl]prop-2-enoate
  • (E)-3-[3-(2-morpholino-4-oxo-1-benzopyran-8-yl)phenyl]-2-propenoic acid methyl ester
  • methyl (E)-3-[3-(2-morpholin-4-yl-4-oxo-chromen-8-yl)phenyl]prop-2-enoate
  • (E)-3-[3-(4-keto-2-morpholino-chromen-8-yl)phenyl]acrylic acid methyl ester
  • (E)-3-[3-(2-morpholino-4-oxo-8-chromenyl)phenyl]prop-2-enoic acid methyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0028 0.0016 0.0016
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0154 0.0202 0.0202
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.008 0.1114
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0095 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.1156 0.1677 0.1676
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.001 0.0141
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0017 0.0233
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0021 0.0006 0.0004
Brugia malayi hypothetical protein 0.049 0.0697 0.0697
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0032 0.0023 0.0023
Brugia malayi Cytochrome P450 family protein 0.004 0.0035 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0095 0.0115 0.1615
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0012 0.0012
Schistosoma mansoni rab6-interacting 0.0061 0.0066 0.0066
Brugia malayi Doublecortin family protein 0.0061 0.0066 0.0066
Brugia malayi putative neuropeptide receptor NPR1 0.0024 0.0012 0.0012
Schistosoma mansoni lamin 0.0086 0.0102 0.0102
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0002 0.0031
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.2316 0.3386 0.3385
Echinococcus granulosus neuropeptides capa receptor 0.0024 0.0012 0.0012
Echinococcus multilocularis cpg binding protein 0.0097 0.0118 0.0118
Schistosoma mansoni lozenge 0.0061 0.0066 0.0066
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0017 0.01
Schistosoma mansoni survival motor neuron protein 0.0154 0.0202 0.0202
Brugia malayi hypothetical protein 0.018 0.0241 0.0241
Brugia malayi hypothetical protein 0.0018 0.0002 0.0002
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0046 0.0135
Loa Loa (eye worm) neuropeptide F receptor 0.0024 0.0012 0.001
Trichomonas vaginalis ferritin, putative 0.0018 0.0002 0.0025
Echinococcus granulosus Chromobox protein 3 0.0024 0.0011 0.0011
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0024 0.0012 0.0012
Brugia malayi ERG2 and Sigma1 receptor like protein 0.2316 0.3386 0.3386
Schistosoma mansoni amine GPCR 0.0024 0.0012 0.0012
Echinococcus granulosus voltage dependent calcium channel 0.005 0.0049 0.0049
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0104 0.0129 0.0127
Mycobacterium leprae Conserved hypothetical protein 0.003 0.002 0.1222
Schistosoma mansoni 60S ribosomal protein L21 0.0017 0.0002 0.0002
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0017 0.005
Toxoplasma gondii endonuclease IV APN 0.0084 0.0099 0.0591
Onchocerca volvulus 0.0024 0.0012 0.0004
Mycobacterium tuberculosis Probable dehydrogenase 0.0108 0.0135 0.8837
Loa Loa (eye worm) CYP4Cod1 0.004 0.0035 0.0032
Schistosoma mansoni cytochrome P450 0.003 0.002 0.002
Brugia malayi Cytochrome P450 family protein 0.003 0.002 0.002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0012 0.0012
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0115 0.0144 0.0427
Schistosoma mansoni chromobox protein 0.0024 0.0011 0.0011
Brugia malayi Serotonin receptor 0.0024 0.0012 0.0012
Plasmodium falciparum thioredoxin reductase 0.0047 0.0046 0.0272
Loa Loa (eye worm) hypothetical protein 0.0086 0.0102 0.01
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0025 0.0013 0.0013
Schistosoma mansoni neuropeptide receptor 0.0024 0.0012 0.0012
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.6808 1 1
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0019 0.0269
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0046 0.0272
Onchocerca volvulus Neuropeptide F receptor homolog 0.0024 0.0012 0.0004
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0107 0.0134 0.0132
Loa Loa (eye worm) hypothetical protein 0.0028 0.0016 0.0014
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0197 0.0265 0.0265
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.005 0.0049 0.0049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0051 0.0716
Leishmania major cytochrome p450-like protein 0.004 0.0035 0.0102
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0024 0.0012 0.0012
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.003 0.002 0.1404
Onchocerca volvulus 0.0122 0.0156 0.0147
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.012 0.0153 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0019 0.0114
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.001
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.003 0.002 0.1404
Echinococcus granulosus sodium and chloride dependent glycine 0.1156 0.1677 0.1677
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0012 0.0012
Echinococcus multilocularis fmrfamide receptor 0.0024 0.0012 0.0012
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0021 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.1156 0.1677 0.1676
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.001
Onchocerca volvulus 0.0024 0.0012 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0023 0.0316
Echinococcus granulosus alpha 1A adrenergic receptor 0.0024 0.0012 0.0012
Echinococcus multilocularis dro:myosuppressin receptor 0.0024 0.0012 0.0012
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0109 0.0136 0.8918
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.008 0.1114
Echinococcus multilocularis neuropeptides capa receptor 0.0024 0.0012 0.0012
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0067 0.0075 0.0075
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.005 0.0049 0.0049
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0024 0.0012 0.0012
Echinococcus granulosus geminin 0.0353 0.0496 0.0496
Echinococcus granulosus intermediate filament protein 0.0086 0.0102 0.0102
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0021 0.0006 0.0006
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0032 0.0023 0.0023
Echinococcus multilocularis geminin 0.0353 0.0496 0.0496
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.001
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0024 0.0012 0.0012
Brugia malayi CXXC zinc finger family protein 0.0092 0.0111 0.0111
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0021 0.0006 0.0006
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0042 0.0037 0.0037
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0045 0.0042 0.0581
Echinococcus granulosus hypothetical protein 0.0024 0.0012 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0095 0.1329
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0145 0.0189 0.0187
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.1156 0.1677 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.001
Schistosoma mansoni sodium-dependent amino acid transporter 0.1156 0.1677 0.1677
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0059 0.0828
Loa Loa (eye worm) hypothetical protein 0.0754 0.1087 0.1085
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0115 0.0144 0.7597
Loa Loa (eye worm) hypothetical protein 0.0071 0.008 0.0078
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0012 0.0012
Trichomonas vaginalis CMGC family protein kinase 0.0107 0.0134 0.1876
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0022 0.0008 0.0008
Brugia malayi Sodium:neurotransmitter symporter family protein 0.1156 0.1677 0.1677
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0087 0.1215
Echinococcus multilocularis musashi 0.0086 0.0102 0.0102
Echinococcus multilocularis Ankyrin 0.0031 0.0021 0.0021
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.005 0.0049 0.0049
Echinococcus granulosus tachykinin peptides receptor 99D 0.0024 0.0012 0.0012
Echinococcus multilocularis fmrfamide receptor 0.0024 0.0012 0.0012
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.1156 0.1677 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.001
Echinococcus granulosus voltage dependent calcium channel 0.005 0.0049 0.0049
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.005 0.0049 0.0144
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.008 0.1114
Trichomonas vaginalis chromobox protein, putative 0.0024 0.0011 0.0154
Brugia malayi MAP kinase sur-1 0.0107 0.0134 0.0134
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.003 0.002 0.1404
Echinococcus granulosus dnaJ subfamily B 0.1305 0.1897 0.1897
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0017 0.01
Brugia malayi hypothetical protein 0.1156 0.1677 0.1677
Onchocerca volvulus 0.0024 0.0012 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0027 0.0383
Schistosoma mansoni biogenic amine (5HT) receptor 0.0024 0.0012 0.0012
Echinococcus multilocularis Chromo domain 0.0024 0.0011 0.0011
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.0075 0.0075
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0012 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0095 0.0115 0.1615
Onchocerca volvulus 0.0024 0.0012 0.0004
Mycobacterium leprae conserved hypothetical protein 0.0022 0.0008 0.0424
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.003 0.002 0.1404
Loa Loa (eye worm) inositol-1 0.0115 0.0144 0.0142
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0024 0.0012 0.0012
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0019 0.0114
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0024 0.0012 0.0012
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.003 0.002 0.1404
Brugia malayi CHD4 protein 0.0029 0.0019 0.0019
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0024 0.0012 0.0012
Onchocerca volvulus 0.1156 0.1677 0.1671
Brugia malayi hypothetical protein 0.0024 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0353 0.0496 0.0496
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.001
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0011 0.0154
Echinococcus multilocularis chromobox protein 2 0.0024 0.0011 0.0011
Echinococcus granulosus dro:myosuppressin receptor 0.0024 0.0012 0.0012
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.003 0.002 0.1325
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0021 0.0006 0.0006
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0024 0.0011 0.0011
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0018 0.0002 0.0006
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0009
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0017 0.005
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0008 0.0536
Mycobacterium ulcerans bacterioferritin BfrA 0.0018 0.0002 0.0125
Schistosoma mansoni voltage-gated potassium channel 0.0089 0.0107 0.0107
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0024 0.0012 0.0012
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.003 0.002 0.002
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0067 0.0075 0.4878
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.001
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0017 0.01
Mycobacterium ulcerans endonuclease IV 0.0084 0.0099 0.6859
Trichomonas vaginalis PIKK family atypical protein kinase 0.0064 0.0069 0.0972
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.001
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0011 0.047
Brugia malayi Dopamine receptor protein 1 0.0024 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.001
Schistosoma mansoni biogenic amine (5HT) receptor 0.0024 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.001
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.003 0.002 0.1325
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0024 0.0012 0.001
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0046 0.0044
Loa Loa (eye worm) G-protein coupled receptor 0.0024 0.0012 0.001
Echinococcus multilocularis g protein coupled receptor 0.0024 0.0012 0.0012
Plasmodium vivax heterochromatin protein 1, putative 0.0024 0.0011 0.0065
Schistosoma mansoni chromobox protein 0.0082 0.0097 0.0097
Loa Loa (eye worm) heterochromatin protein 1 0.0082 0.0097 0.0095
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.003 0.002 0.1404
Echinococcus granulosus G protein coupled receptor 139 0.0024 0.0012 0.0012
Schistosoma mansoni sodium/chloride dependent transporter 0.1157 0.1679 0.1679
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.0136 0.717
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0115 0.0144 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0024 0.0024
Echinococcus granulosus ferritin 0.0018 0.0002 0.0002
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0024 0.0024
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.003 0.002 0.1325
Schistosoma mansoni hypothetical protein 0.0071 0.008 0.008
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.1156 0.1677 0.1677
Echinococcus granulosus tm gpcr rhodopsin 0.059 0.0844 0.0844
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.001
Brugia malayi intermediate filament protein 0.0086 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0122 0.0156 0.0153
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.003 0.002 0.1404
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0032 0.0023 0.0067
Brugia malayi Cytochrome P450 family protein 0.0092 0.0111 0.0111
Loa Loa (eye worm) voltage-dependent calcium channel 0.005 0.0049 0.0047
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0024 0.0012 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0087 0.1215
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0024 0.0012 0.0012
Echinococcus granulosus uncharacterized sodium dependent transporter 0.1156 0.1677 0.1677
Onchocerca volvulus 0.0024 0.0012 0.0004
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0021 0.0006 0.0006
Brugia malayi Intermediate filament tail domain containing protein 0.0086 0.0102 0.0102
Brugia malayi neuropeptide F receptor 0.0024 0.0012 0.0012
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0021 0.0006 0.0004
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0115 0.0144 0.0427
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0024 0.0012 0.0012
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0019 0.0908
Schistosoma mansoni neuropeptide receptor 0.0024 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0003
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0012 0.0012
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0032 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.1156 0.1677 0.1676
Toxoplasma gondii target of rapamycin (TOR), putative 0.0071 0.008 0.0475
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0023 0.0316
Schistosoma mansoni amine GPCR 0.0024 0.0012 0.0012
Schistosoma mansoni biogenic amine receptor 0.0024 0.0012 0.0012
Echinococcus multilocularis serotonin transporter 0.6808 1 1
Echinococcus multilocularis voltage dependent calcium channel 0.005 0.0049 0.0049
Onchocerca volvulus Netrin receptor homolog 0.003 0.002 0.0012
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.003 0.002 0.1325
Echinococcus multilocularis serine protein kinase ATM 0.0018 0.0002 0.0002
Brugia malayi Sodium:neurotransmitter symporter family protein 0.1156 0.1677 0.1677
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0024 0.0012 0.0012
Brugia malayi Serotonin receptor 0.0024 0.0012 0.0012
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0115 0.0144 0.0427
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0024 0.0012 0.001
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0028 0.0016 0.0016
Echinococcus granulosus g protein coupled receptor 0.0024 0.0012 0.0012
Echinococcus granulosus 6 phosphofructokinase 0.0109 0.0136 0.0136
Brugia malayi sulfakinin receptor protein 0.0024 0.0012 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0051 0.0716
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0024 0.0024
Onchocerca volvulus 0.0024 0.0012 0.0004
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0012 0.0012
Brugia malayi Pre-SET motif family protein 0.0065 0.0071 0.0071
Schistosoma mansoni opsin-like receptor 0.0024 0.0012 0.0012
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0029 0.0019 0.0019
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0115 0.0144 0.2022
Echinococcus granulosus chromobox protein 1 0.0082 0.0097 0.0097
Loa Loa (eye worm) doublecortin family protein 0.0061 0.0066 0.0064
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0024 0.0012 0.0012
Echinococcus granulosus netrin receptor unc 5 0.003 0.002 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0017 0.0233
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0025 0.0013 0.0013
Brugia malayi follicle stimulating hormone receptor 0.0279 0.0386 0.0386
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0019 0.0114
Echinococcus multilocularis netrin receptor unc 5 0.003 0.002 0.002
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.003 0.002 0.1404
Plasmodium falciparum amino acid transporter, putative 0.1156 0.1677 1
Echinococcus multilocularis Polycystic kidney disease protein 0.0061 0.0066 0.0066
Echinococcus multilocularis serotonin receptor 0.0024 0.0012 0.0012
Brugia malayi Tachykinin-like peptides receptor 99D 0.0024 0.0012 0.0012
Schistosoma mansoni apoferritin-2 0.0018 0.0002 0.0002
Brugia malayi phosphofructokinase 0.0109 0.0136 0.0136
Schistosoma mansoni cpg binding protein 0.0092 0.0111 0.0111
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0024 0.0011 0.0011
Echinococcus granulosus peptide allatostatin:somatostatin 0.0024 0.0012 0.0012
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.0075 0.0075
Trichomonas vaginalis chromobox protein, putative 0.0082 0.0097 0.1359
Schistosoma mansoni lamin 0.0086 0.0102 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0006 0.0089
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.003 0.002 0.0018
Brugia malayi G protein-coupled receptor 0.0024 0.0012 0.0012
Schistosoma mansoni intermediate filament proteins 0.0086 0.0102 0.0102
Brugia malayi larval opioid receptor 0.0024 0.0012 0.0012
Brugia malayi cytochrome P450 0.003 0.002 0.002
Echinococcus granulosus g protein coupled receptor 0.0024 0.0012 0.0012
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.1156 0.1677 0.1676
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0136 0.191
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0095 0.0115 0.0341
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0039 0.0034 0.01
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0046 0.2985
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0011 0.0154
Schistosoma mansoni voltage-gated potassium channel 0.0028 0.0016 0.0016
Echinococcus multilocularis hyperpolarization activated cyclic 0.0021 0.0006 0.0006
Echinococcus multilocularis hyperpolarization activated cyclic 0.0021 0.0006 0.0006
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0024 0.0011 0.0065
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.003 0.002 0.1404
Brugia malayi Dopamine receptor 0.0024 0.0012 0.0012
Brugia malayi hypothetical protein 0.0028 0.0017 0.0017
Brugia malayi Associated with TFs and helicases family protein 0.0024 0.0011 0.0011
Echinococcus granulosus neuropeptide Y receptor 0.0024 0.0012 0.0012
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0304 0.0424 0.0424
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0011 0.0154
Trypanosoma brucei trypanothione reductase 0.0047 0.0046 0.0135
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0084 0.0099 0.6434
Trichomonas vaginalis chromobox protein, putative 0.0055 0.0056 0.0787
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0087 0.1215
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0018 0.0002 0.0002
Brugia malayi ORL1-like opioid receptor 0.0024 0.0012 0.0012
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.0136 0.0134
Schistosoma mansoni hypothetical protein 0.0033 0.0024 0.0024
Echinococcus granulosus tm gpcr rhodopsin 0.0024 0.0012 0.0012
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0095 0.0115 0.6044
Echinococcus granulosus expressed protein 0.0018 0.0002 0.0002
Trypanosoma cruzi cytochrome P450, putative 0.004 0.0035 0.0102
Brugia malayi hypothetical protein 0.0754 0.1087 0.1087
Schistosoma mansoni serine/threonine protein kinase 0.0107 0.0134 0.0134
Brugia malayi Cytochrome P450 family protein 0.004 0.0035 0.0035
Brugia malayi M-phase phosphoprotein, mpp8 0.0122 0.0156 0.0156
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.1156 0.1677 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0145 0.0189 0.0559
Schistosoma mansoni hypothetical protein 0.003 0.002 0.002
Brugia malayi Valyl-tRNA synthetase 0.0024 0.0011 0.0011
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0109 0.0136 0.0136
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0019 0.0269
Mycobacterium tuberculosis Probable reductase 0.0108 0.0135 0.8837
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0035 0.0027 0.0383
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0023 0.0316
Echinococcus multilocularis voltage dependent calcium channel 0.005 0.0049 0.0049
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0084 0.0099 0.0591
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0084 0.0099 0.0099
Trichomonas vaginalis chromobox protein, putative 0.0055 0.0056 0.0787
Echinococcus granulosus tumor protein p63 0.0713 0.1025 0.1025
Schistosoma mansoni biogenic amine receptor 0.0024 0.0012 0.0012
Leishmania major phosphatidylinositol 3-kinase, putative 0.0032 0.0023 0.0067
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0032 0.0023 0.0067
Brugia malayi GnHR receptor homolog 0.0024 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.001
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0021 0.0006 0.0006
Trichomonas vaginalis helicase, putative 0.0021 0.0006 0.0089
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0024 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0009
Schistosoma mansoni myosin xvIII 0.0024 0.0012 0.0012
Echinococcus granulosus serotonin transporter 0.6808 1 1
Brugia malayi 6-phosphofructokinase 0.0109 0.0136 0.0136
Echinococcus granulosus biogenic amine 5HT receptor 0.0024 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.001
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0022 0.0008 0.0568
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0107 0.0134 0.0396
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0045 0.0042 0.0581
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0024 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0022 0.0008 0.0006
Onchocerca volvulus 0.0031 0.0021 0.0013
Loa Loa (eye worm) neuropeptide F receptor 0.0024 0.0012 0.001
Schistosoma mansoni inositol monophosphatase 0.0115 0.0144 0.0144
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.003 0.002 0.1325
Brugia malayi RE15519p 0.0024 0.0012 0.0012
Schistosoma mansoni neuropeptide F-like receptor 0.0024 0.0012 0.0012
Schistosoma mansoni cellular tumor antigen P53 0.0104 0.0129 0.0129
Trichomonas vaginalis PIKK family atypical protein kinase 0.0056 0.0058 0.0817
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.1156 0.1677 0.1676
Echinococcus granulosus mitogen activated protein kinase 3 0.0107 0.0134 0.0134
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0024 0.0012 0.0012
Onchocerca volvulus 0.0024 0.0012 0.0004
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.003 0.002 0.1325
Echinococcus multilocularis sodium and chloride dependent glycine 0.1156 0.1677 0.1677
Brugia malayi Calcitonin receptor-like protein seb-1 0.0104 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.001
Echinococcus granulosus Ankyrin 0.0031 0.0021 0.0021
Schistosoma mansoni hypothetical protein 0.0033 0.0024 0.0024
Echinococcus multilocularis ferritin 0.0018 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0011 0.0154
Echinococcus granulosus neuropeptide receptor A26 0.0983 0.1424 0.1424
Echinococcus multilocularis mitogen activated protein kinase 3 0.0107 0.0134 0.0134
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0025 0.0013 0.0013
Entamoeba histolytica hypothetical protein 0.0024 0.0011 0.047
Schistosoma mansoni adenoreceptor 0.0024 0.0012 0.0012
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0136 0.191
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.1156 0.1677 1
Leishmania major C-8 sterol isomerase-like protein 0.2316 0.3386 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0107 0.0134 0.0396
Brugia malayi hypothetical protein 0.0024 0.0012 0.0012
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.1156 0.1677 0.1677
Echinococcus multilocularis lamin 0.0086 0.0102 0.0102
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.1156 0.1677 0.1677
Leishmania major cytochrome p450-like protein 0.003 0.002 0.006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.008 0.1114
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0032 0.0023 0.0023
Echinococcus granulosus fmrfamide receptor 0.0024 0.0012 0.0012
Brugia malayi hypothetical protein 0.0024 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0084 0.0099 0.0097
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0024 0.0012 0.0012
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0095 0.0115 0.0341
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.001
Plasmodium falciparum transporter, putative 0.1156 0.1677 1
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0021 0.0006 0.0006
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0024 0.0012 0.0012
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0075 0.5167
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.003 0.002 0.1404
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0023 0.0316
Toxoplasma gondii aldehyde dehydrogenase 0.0067 0.0075 0.0445
Schistosoma mansoni hypothetical protein 0.0024 0.0012 0.0012
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0061 0.0065 0.0065
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0082 0.0097 0.0095
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.005 0.0049 0.0049
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0065 0.0071 0.0071
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0024 0.0012 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0006 0.0089
Mycobacterium ulcerans bacterioferritin BfrB 0.0018 0.0002 0.0125
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.003 0.002 0.1404
Loa Loa (eye worm) hypothetical protein 0.6808 1 1
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.008 0.008
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0021 0.0006 0.0006
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0019 0.0114
Loa Loa (eye worm) hypothetical protein 0.1156 0.1677 0.1676
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0107 0.0134 0.0396
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0082 0.0097 0.0097
Echinococcus granulosus voltage gated potassium channel 0.0028 0.0016 0.0016
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0071 0.0071
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.012 0.0153 1
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0024 0.0011 0.0065
Schistosoma mansoni hypothetical protein 0.0033 0.0024 0.0024
Brugia malayi hypothetical protein 0.0024 0.0012 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0051 0.0714
Mycobacterium ulcerans 6-phosphofructokinase 0.0109 0.0136 0.9446
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0017 0.005
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0072 0.0082 0.1141
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0023 0.0316
Echinococcus granulosus mitogen activated protein kinase 0.0107 0.0134 0.0134
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.012 0.0153 1
Onchocerca volvulus 0.0024 0.0012 0.0004
Loa Loa (eye worm) hypothetical protein 0.0031 0.0021 0.0019
Loa Loa (eye worm) hypothetical protein 0.1184 0.1719 0.1717
Echinococcus granulosus neuropeptide receptor 0.0024 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.001
Schistosoma mansoni cpg binding protein 0.0097 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0122 0.0156 0.0154
Echinococcus granulosus biogenic amine 5HT receptor 0.0024 0.0012 0.0012
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0084 0.0099 0.0591
Onchocerca volvulus 0.0502 0.0715 0.0707
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.003 0.002 0.1404
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0021 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.0024 0.0012 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0051 0.0716
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0042 0.0037 0.0037
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0115 0.0144 0.2022
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0108 0.0135 0.8837
Loa Loa (eye worm) hypothetical protein 0.0061 0.0066 0.0064
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0018 0.0002 0.0118
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0024 0.0024
Brugia malayi hypoxia-induced factor 1 0.0166 0.0221 0.0221
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0028 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.001
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.003 0.002 0.1325
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0086 0.0102 0.01
Brugia malayi Heterochromatin protein 1 0.0082 0.0097 0.0097
Echinococcus multilocularis neuropeptide Y receptor 0.0024 0.0012 0.0012
Echinococcus multilocularis lipoxygenase domain containing protein 0.0061 0.0066 0.0066
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.003 0.002 0.002
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.005 0.0049 0.0049
Entamoeba histolytica hypothetical protein 0.0024 0.0011 0.047
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0089 0.0107 0.0107
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0006 0.0035
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.001
Brugia malayi Cyclic-nucleotide gated cation channel 0.0021 0.0006 0.0006
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.0136 0.0403
Schistosoma mansoni hypothetical protein 0.1305 0.1897 0.1897
Brugia malayi hypothetical protein 0.0024 0.0012 0.0012
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0034 0.0025 0.0352
Loa Loa (eye worm) phosphatidylinositol 3 0.0095 0.0115 0.0113
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0104 0.0129 0.0129
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0011 0.0154
Brugia malayi 6-phosphofructokinase 0.0109 0.0136 0.0136
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0006 0.0089
Loa Loa (eye worm) CXXC zinc finger family protein 0.0092 0.0111 0.0109
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.008 0.1114
Echinococcus granulosus lipoxygenase domain containing protein 0.0061 0.0066 0.0066
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0012 0.0012
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0145 0.0189 0.0189
Onchocerca volvulus 0.0024 0.0012 0.0004
Trichomonas vaginalis CMGC family protein kinase 0.0107 0.0134 0.1876
Trypanosoma cruzi target of rapamycin kinase 3 0.0075 0.0087 0.0257
Onchocerca volvulus 0.004 0.0034 0.0026
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.005 0.0049 0.0049
Echinococcus multilocularis dnaJ subfamily B 0.1305 0.1897 0.1897
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0009
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.1156 0.1677 0.1677
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.001
Onchocerca volvulus 0.0086 0.0102 0.0094
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0025 0.0013 0.0013
Brugia malayi putative neuropeptide receptor 0.0024 0.0012 0.0012
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0024 0.0012 0.0012
Echinococcus multilocularis Protein lozenge 0.0061 0.0066 0.0066
Brugia malayi Uncoordinated protein 44 0.003 0.002 0.002
Echinococcus granulosus neuropeptide receptor 0.0024 0.0012 0.0012
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0012 0.0012
Onchocerca volvulus 0.0024 0.0012 0.0004
Schistosoma mansoni rab6-interacting 0.0061 0.0066 0.0066
Schistosoma mansoni lipoxygenase 0.0194 0.0261 0.0261
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0019 0.0114
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0018 0.0002 0.0002
Schistosoma mansoni opsin-like receptor 0.0024 0.0012 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0006 0.0089
Schistosoma mansoni sodium/chloride dependent transporter 0.1156 0.1677 0.1677
Onchocerca volvulus 0.0104 0.0129 0.0121
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0024 0.0011 0.0065
Schistosoma mansoni ferritin 0.0018 0.0002 0.0002
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.0136 0.717
Loa Loa (eye worm) hypothetical protein 0.0104 0.0129 0.0127
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0107 0.0134 0.0396
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.059 0.0844 0.0844
Echinococcus granulosus chromobox protein 1 0.0082 0.0097 0.0097
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0019 0.0269
Loa Loa (eye worm) hypothetical protein 0.0052 0.0052 0.005
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0011 0.0154
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0024 0.0024
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0095 0.0115 0.0341
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0107 0.0134 0.0396
Echinococcus multilocularis orexin receptor type 2 0.0024 0.0012 0.0012
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0082 0.0097 0.0097
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.003 0.002 0.1325
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0024 0.0011 0.0011
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0024 0.0012 0.0012
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0095 0.0115 0.6044
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.1156 0.1677 0.1677
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0005 0.0073
Echinococcus multilocularis mitogen activated protein kinase 0.0107 0.0134 0.0134
Echinococcus multilocularis serotonin receptor 0.0024 0.0012 0.0012
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.003 0.002 0.1404
Schistosoma mansoni neuropeptide F-like receptor 0.0024 0.0012 0.0012
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1711 0.2495 0.2495
Toxoplasma gondii cytochrome p450 superfamily protein 0.003 0.002 0.0121
Onchocerca volvulus 0.0024 0.0012 0.0004
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0024 0.0011 0.0011
Leishmania major lanosterol 14-alpha-demethylase, putative 0.003 0.002 0.006
Echinococcus multilocularis neuropeptide receptor 0.0024 0.0012 0.0012
Echinococcus multilocularis g-protein coupled receptor 0.0024 0.0012 0.0012
Schistosoma mansoni loxhd1 0.0061 0.0066 0.0066
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0045 0.0042 0.0581
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0029 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.001
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0098 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.001
Loa Loa (eye worm) hypothetical protein 0.0104 0.0129 0.0127
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0011 0.0065
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0009
Echinococcus granulosus neuropeptide FF receptor 2 0.0024 0.0012 0.0012
Echinococcus granulosus g protein coupled receptor 0.0024 0.0012 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.008 0.1114
Leishmania major trypanothione reductase 0.0047 0.0046 0.0135
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0095 0.0115 0.0115
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0095 0.0115 0.0341
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.004 0.0035 0.2391
Brugia malayi G-protein coupled receptor 0.0024 0.0012 0.0012
Loa Loa (eye worm) G-protein coupled receptor 0.0024 0.0012 0.001
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0155 0.0205 0.0205
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0006 0.0089
Schistosoma mansoni voltage-gated potassium channel 0.0028 0.0016 0.0016
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0018 0.0002 0.0006
Loa Loa (eye worm) RecQ helicase 0.0023 0.001 0.0008
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0024 0.0012 0.001
Schistosoma mansoni lipoxygenase 0.0304 0.0424 0.0424
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0021 0.0006 0.0085
Echinococcus granulosus transcription factor Dp 1 0.0084 0.0099 0.0099
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.1156 0.1677 0.1677
Plasmodium falciparum glutathione reductase 0.0047 0.0046 0.0272
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0059 0.0828
Brugia malayi hypothetical protein 0.0122 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.001
Onchocerca volvulus 0.0086 0.0102 0.0094
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.001
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.003 0.002 0.1325
Loa Loa (eye worm) hypothetical protein 0.1156 0.1677 0.1676
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0032 0.0023 0.0067
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0024 0.0012 0.0012
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0019 0.1431
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0071 0.0071
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0024 0.0012 0.0004
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0024 0.0012 0.0012
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0103 0.0127 0.8286
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0024 0.0012 0.0012
Echinococcus multilocularis transcription factor Dp 1 0.0084 0.0099 0.0099
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0024 0.0012 0.0012
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.1156 0.1677 0.1677
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0075 0.5167
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0012 0.0012
Leishmania major cytochrome p450-like protein 0.003 0.002 0.006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0012 0.0012
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0095 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.001
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.1156 0.1677 0.1677
Onchocerca volvulus 0.0089 0.0107 0.0099
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.001
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.1156 0.1677 0.1677
Onchocerca volvulus 0.0024 0.0012 0.0004
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0024 0.0012 0.0012
Trichomonas vaginalis chromobox protein, putative 0.0024 0.0011 0.0154
Loa Loa (eye worm) hypothetical protein 0.0031 0.0021 0.0019
Brugia malayi hypothetical protein 0.0024 0.0012 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0095 0.0115 0.1615
Echinococcus multilocularis Chromobox protein 3 0.0024 0.0011 0.0011
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.0136 0.717
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.003 0.002 0.1404
Brugia malayi Melatonin receptor type 1A 0.0024 0.0012 0.0012
Echinococcus granulosus Chromo domain 0.0024 0.0011 0.0011
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0003 0.0003
Leishmania major hypothetical protein, conserved 0.0028 0.0017 0.005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0012 0.0012
Echinococcus multilocularis voltage gated potassium channel 0.0028 0.0016 0.0016
Mycobacterium tuberculosis Probable oxidoreductase 0.012 0.0153 1
Schistosoma mansoni amine GPCR 0.0024 0.0012 0.0012
Echinococcus multilocularis g protein coupled receptor 0.0024 0.0012 0.0012
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0067 0.0075 0.0075
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0304 0.0424 0.0424
Trichomonas vaginalis CMGC family protein kinase 0.0107 0.0134 0.1876
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0115 0.0144 0.0861
Echinococcus multilocularis neuropeptide receptor 0.0024 0.0012 0.0012
Brugia malayi Sodium:neurotransmitter symporter family protein 0.1156 0.1677 0.1677
Echinococcus multilocularis sex peptide receptor 0.0024 0.0012 0.0012
Echinococcus multilocularis tumor protein p63 0.0713 0.1025 0.1025
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0006 0.0006
Echinococcus granulosus Polycystic kidney disease protein 0.0061 0.0066 0.0066
Brugia malayi Pre-SET motif family protein 0.0441 0.0625 0.0625
Toxoplasma gondii hypothetical protein 0.1156 0.1677 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0024 0.0012 0.0012
Loa Loa (eye worm) cytochrome P450 family protein 0.004 0.0035 0.0032
Echinococcus multilocularis G-protein coupled receptor, putative 0.0024 0.0012 0.0012
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0032 0.0023 0.0067
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.0136 0.0403
Loa Loa (eye worm) solute carrier family 6 member 4 0.6808 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0107 0.0134 0.1876
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0052 0.0726
Mycobacterium ulcerans hypothetical protein 0.0022 0.0008 0.0568
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0024 0.0012 0.0012
Brugia malayi hypothetical protein 0.0061 0.0066 0.0066
Brugia malayi hypothetical protein 0.0024 0.0012 0.0012
Toxoplasma gondii FATC domain-containing protein 0.0018 0.0002 0.0013
Echinococcus granulosus serine protein kinase ATM 0.0018 0.0002 0.0002
Onchocerca volvulus 0.0061 0.0066 0.0058
Echinococcus granulosus 7tm_1 domain containing protein 0.0024 0.0012 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0006 0.0089
Trichomonas vaginalis chromobox protein, putative 0.0024 0.0011 0.0154
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0012 0.0012
Echinococcus multilocularis neuropeptide receptor A26 0.0983 0.1424 0.1424
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0145 0.0189 0.0189
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0019 0.0269
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.001
Leishmania major protein kinase, putative 0.0025 0.0013 0.0038
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0107 0.0134 0.0396
Plasmodium vivax SET domain protein, putative 0.0065 0.0071 0.0426
Treponema pallidum sodium- and chloride- dependent transporter 0.6808 1 1
Schistosoma mansoni chromobox protein 0.0024 0.0011 0.0011
Echinococcus granulosus single minded 2 0.0047 0.0045 0.0045
Mycobacterium ulcerans putative regulatory protein 0.004 0.0034 0.2381
Echinococcus granulosus cpg binding protein 0.0097 0.0118 0.0118
Toxoplasma gondii hypothetical protein 0.0039 0.0033 0.0199
Loa Loa (eye worm) glutathione reductase 0.0047 0.0046 0.0044
Plasmodium falciparum heterochromatin protein 1 0.0024 0.0011 0.0065
Chlamydia trachomatis endonuclease IV 0.0084 0.0099 0.0591
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0012 0.0012
Trichomonas vaginalis inositol monophosphatase, putative 0.0115 0.0144 0.2022
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0019 0.0114
Schistosoma mansoni growth hormone secretagogue receptor 0.0024 0.0012 0.0012
Echinococcus multilocularis lipoxygenase domain containing protein 0.0061 0.0066 0.0066
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0019 0.0114
Brugia malayi Protein cec-1. 0.0024 0.0011 0.0011
Trypanosoma cruzi cytochrome p450-like protein, putative 0.003 0.002 0.006
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.001 0.0141
Loa Loa (eye worm) histone methyltransferase 0.0031 0.0021 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0051 0.0714
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0145 0.0189 0.0559
Brugia malayi Inositol-1 0.0115 0.0144 0.0144
Echinococcus granulosus GPCR family 2 0.0033 0.0024 0.0024
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0067 0.0075 0.022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0056 0.0058 0.0817
Trypanosoma brucei protein kinase, putative 0.0107 0.0134 0.0396
Mycobacterium leprae putative cytochrome p450 0.003 0.002 0.1222
Plasmodium falciparum LCCL domain-containing protein 0.0061 0.0066 0.0394
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0017 0.01
Brugia malayi chromobox protein homolog 3 0.0052 0.0052 0.0052
Entamoeba histolytica hypothetical protein 0.0024 0.0011 0.047
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0002 0.0006
Loa Loa (eye worm) CHromoDomain protein family member 0.0029 0.0019 0.0016
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.003 0.002 0.1325
Schistosoma mansoni neuropeptide receptor 0.0024 0.0012 0.0012
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0279 0.0386 0.0384
Echinococcus granulosus uncharacterized sodium dependent transporter 0.1156 0.1677 0.1677
Brugia malayi hypothetical protein 0.0024 0.0012 0.0012
Echinococcus multilocularis G protein coupled receptor 139 0.0024 0.0012 0.0012
Schistosoma mansoni voltage-gated cation channel 0.005 0.0049 0.0049
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.005 0.0049 0.0049
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.005 0.0049 0.0144
Echinococcus multilocularis RUN 0.0061 0.0066 0.0066
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0145 0.0189 0.0559
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0095 0.0115 0.0341
Echinococcus granulosus g-protein coupled receptor 0.0024 0.0012 0.0012
Brugia malayi glutathione reductase 0.0047 0.0046 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0087 0.1215
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0136 0.191
Loa Loa (eye worm) hypothetical protein 0.0061 0.0066 0.0064
Onchocerca volvulus 0.049 0.0697 0.0689
Echinococcus granulosus neuropeptides capa receptor 0.0024 0.0012 0.0012
Brugia malayi Death domain containing protein 0.003 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0039 0.0033 0.0031
Echinococcus granulosus lamin dm0 0.0086 0.0102 0.0102
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0002 0.0002
Echinococcus granulosus neuropeptide s receptor 0.0983 0.1424 0.1424
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0087 0.1215
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0046 0.0046
Schistosoma mansoni hypothetical protein 0.003 0.002 0.002
Onchocerca volvulus 0.0024 0.0012 0.0004
Schistosoma mansoni amine GPCR 0.0024 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.049 0.0697 0.0695
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.001
Echinococcus granulosus survival motor neuron protein 1 0.0754 0.1087 0.1087
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0115 0.0144 0.0427
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.0136 0.0136
Schistosoma mansoni ankyrin 23/unc44 0.003 0.002 0.002
Echinococcus multilocularis g protein coupled receptor 0.0024 0.0012 0.0012
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.003 0.002 0.1404
Loa Loa (eye worm) hypothetical protein 0.0065 0.0071 0.0069
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.1156 0.1677 0.1677
Brugia malayi cytoplasmic intermediate filament protein 0.0046 0.0044 0.0044
Echinococcus multilocularis inositol monophosphatase 1 0.0115 0.0144 0.0144
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0019 0.0114
Onchocerca volvulus 0.0154 0.0202 0.0194
Echinococcus granulosus lipoxygenase domain containing protein 0.0061 0.0066 0.0066
Loa Loa (eye worm) TYRA-2 protein 0.0024 0.0012 0.001
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.003 0.002 0.1404
Loa Loa (eye worm) hypothetical protein 0.0084 0.01 0.0098
Echinococcus multilocularis lamin dm0 0.0086 0.0102 0.0102
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0098 0.012 0.012
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.003 0.002 0.1325
Echinococcus multilocularis somatostatin receptor 0.0024 0.0012 0.0012
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0108 0.0135 0.8823
Schistosoma mansoni hypothetical protein 0.0113 0.0142 0.0142
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0011 0.0154
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0024 0.0011 0.0065
Schistosoma mansoni opsin-like receptor 0.0024 0.0012 0.0012
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.003 0.002 0.006
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0065 0.0071 0.0426
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0024 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0353 0.0496 0.0496
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.001
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0024 0.0012 0.0012
Echinococcus multilocularis neuropeptide s receptor 0.0983 0.1424 0.1424
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0045 0.0042 0.0581
Loa Loa (eye worm) hypothetical protein 0.0039 0.0033 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0051 0.0714
Brugia malayi hypothetical protein 0.0024 0.0012 0.0012
Trichomonas vaginalis set domain proteins, putative 0.0502 0.0715 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0024 0.0012 0.0012
Trypanosoma cruzi C-8 sterol isomerase, putative 0.2316 0.3386 1
Mycobacterium ulcerans epimerase 0.0022 0.0008 0.0568
Loa Loa (eye worm) hypothetical protein 0.018 0.0241 0.0239
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0108 0.0135 0.8837
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.003 0.002 0.1325
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0024 0.0012 0.0012
Echinococcus granulosus sex peptide receptor 0.0024 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.001
Echinococcus granulosus tm gpcr rhodopsin 0.0024 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0024 0.0011 0.0011
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0136 0.191
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0145 0.0189 0.0189
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.003 0.002 0.1325
Loa Loa (eye worm) hypothetical protein 0.004 0.0035 0.0032
Schistosoma mansoni amine GPCR 0.0024 0.0012 0.0012
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0055 0.0056 0.0048
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.003 0.002 0.1404
Schistosoma mansoni inositol monophosphatase 0.0115 0.0144 0.0144
Loa Loa (eye worm) cytochrome P450 0.003 0.002 0.0018
Echinococcus multilocularis GPCR, family 2 0.0033 0.0024 0.0024
Onchocerca volvulus 0.1156 0.1677 0.1671
Echinococcus granulosus neuropeptide Y receptor 0.0024 0.0012 0.0012
Plasmodium vivax amine transporter, putative 0.1156 0.1677 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0059 0.0828
Echinococcus granulosus hyperpolarization activated cyclic 0.0021 0.0006 0.0006
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0031 0.0021 0.0021
Echinococcus granulosus bloom syndrome protein 0.0023 0.001 0.001
Echinococcus granulosus histone lysine methyltransferase setb 0.0065 0.0071 0.0071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0002 0.0031
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.1156 0.1677 0.1677
Onchocerca volvulus 0.0092 0.0111 0.0103
Echinococcus multilocularis allatostatin A receptor 0.0024 0.0012 0.0012
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.005 0.0049 0.0049
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0021 0.0006 0.0085
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.001
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0108 0.0135 0.8837
Schistosoma mansoni cpg binding protein 0.0097 0.0118 0.0118
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0011 0.047
Giardia lamblia Kinase, CMGC MAPK 0.0107 0.0134 1
Onchocerca volvulus 0.0122 0.0156 0.0147
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0084 0.0099 0.6476
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0012 0.0012
Plasmodium vivax multidomain scavenger receptor, putative 0.0061 0.0066 0.0394
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.001 0.001
Echinococcus multilocularis chromobox protein 1 0.0082 0.0097 0.0097
Echinococcus granulosus chromobox protein 2 0.0024 0.0011 0.0011
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0024 0.0012 0.001
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0095 0.0115 0.0341
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0024 0.0012 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.008 0.1114
Schistosoma mansoni hypothetical protein 0.0154 0.0202 0.0202
Schistosoma mansoni neuropeptide f receptor 76f 0.0024 0.0012 0.0012
Leishmania major ATP-dependent phosphofructokinase 0.0109 0.0136 0.0403
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0019 0.0269
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.003 0.002 0.1404
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0145 0.0189 0.0559
Echinococcus granulosus death domain containing protein 0.003 0.002 0.002
Trypanosoma brucei C-8 sterol isomerase, putative 0.2316 0.3386 1
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.003 0.002 0.1325
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0024 0.0012 0.0012
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0145 0.0189 1
Echinococcus multilocularis neuropeptide Y receptor 0.0024 0.0012 0.0012
Schistosoma mansoni fkbp-rapamycin associated protein 0.0018 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0006 0.0089
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0011 0.0154
Echinococcus multilocularis transfer RNA-Lys 0.004 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.1156 0.1677 0.1676
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0051 0.0716
Echinococcus multilocularis neuropeptides capa receptor 0.0024 0.0012 0.0012
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.0136 0.0134
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0046 0.0044 0.0041
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.003 0.002 0.1404
Brugia malayi PAS domain containing protein 0.0054 0.0055 0.0055
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0045 0.0042 0.0123
Loa Loa (eye worm) hypothetical protein 0.004 0.0035 0.0032
Schistosoma mansoni voltage-gated potassium channel 0.0089 0.0107 0.0107
Schistosoma mansoni ferritin light chain 0.0018 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.1156 0.1677 0.1676
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0006 0.0089
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0011 0.0154
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.001
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.001
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0024 0.0011 0.0011
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0024 0.0012 0.0012
Echinococcus multilocularis 0.003 0.002 0.002
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0024 0.0024
Loa Loa (eye worm) melatonin receptor type 1A 0.0024 0.0012 0.001
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.003 0.002 0.006
Loa Loa (eye worm) cytochrome P450 family protein 0.0092 0.0111 0.0108
Echinococcus granulosus mixed lineage leukemia protein mll 0.0025 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.003 0.002 0.0018
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0018 0.0002 0.0002
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0045 0.0042 0.0581
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0032 0.0023 0.0067
Schistosoma mansoni ferritin light chain 0.0018 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0011 0.0154
Echinococcus multilocularis sodium and chloride dependent glycine 0.1156 0.1677 0.1677
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0002 0.0031
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0024 0.0012 0.0012
Schistosoma mansoni chromobox protein 0.0082 0.0097 0.0097
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0012 0.0012
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0021 0.0006 0.0006
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0031 0.0021 0.0021
Echinococcus granulosus orexin receptor type 2 0.0024 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.001
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0019 0.0269
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.1156 0.1677 0.1677
Schistosoma mansoni single-minded 0.0054 0.0055 0.0055
Trichomonas vaginalis Heterochromatin protein, putative 0.0024 0.0011 0.0154
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.001
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0021 0.0006 0.0006
Giardia lamblia GTOR 0.0095 0.0115 0.8606
Echinococcus multilocularis bloom syndrome protein 0.0023 0.001 0.001
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0018 0.0002 0.0118
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0107 0.0134 0.0799
Trypanosoma brucei cytochrome P450, putative 0.004 0.0035 0.0102
Toxoplasma gondii non-specific serine/threonine protein kinase 0.002 0.0005 0.0031
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0019 0.0114
Loa Loa (eye worm) cytochrome P450 family protein 0.004 0.0035 0.0032
Loa Loa (eye worm) intermediate filament protein 0.0086 0.0102 0.01
Echinococcus multilocularis 6 phosphofructokinase 0.0109 0.0136 0.0136
Brugia malayi bHLH-PAS transcription factor 0.004 0.0034 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0006 0.0089
Loa Loa (eye worm) runx1 0.0061 0.0066 0.0064
Brugia malayi G protein-coupled receptor F59B2.13 0.0024 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.001
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.003 0.002 0.1325
Loa Loa (eye worm) helicase 0.0024 0.0011 0.0009
Schistosoma mansoni hypothetical protein 0.0033 0.0024 0.0024
Brugia malayi Immunoglobulin I-set domain containing protein 0.003 0.002 0.002
Schistosoma mansoni ferritin 0.0018 0.0002 0.0002
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.003 0.002 0.1325
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.003 0.002 0.1325
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0095 0.0115 0.0115
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.003 0.002 0.1325
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0082 0.0097 0.0097
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0045 0.0042 0.0581
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0045 0.0042 0.0581
Brugia malayi hypothetical protein 0.0024 0.0012 0.0012
Toxoplasma gondii transporter, cation channel family protein 0.005 0.0049 0.0291
Echinococcus multilocularis chromobox protein 1 0.0082 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.049 0.0697 0.0695
Schistosoma mansoni biogenic amine receptor 0.0024 0.0012 0.0012
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0024 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0033 0.0024 0.0022
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0002 0.0002
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0098 0.012 0.012
Echinococcus granulosus cytochrome P450 2K1 0.003 0.002 0.002
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0072 0.0082 0.1141
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.1156 0.1677 0.1677
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.001
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.001
Schistosoma mansoni ferritin 0.0018 0.0002 0.0002
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0145 0.0189 0.0189
Echinococcus granulosus hyperpolarization activated cyclic 0.0021 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0072 0.0082 0.008
Loa Loa (eye worm) calcium channel 0.005 0.0049 0.0047
Brugia malayi neuropeptide F receptor 0.0024 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.001
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.1156 0.1677 0.1677
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0002
Echinococcus granulosus somatostatin receptor 0.0024 0.0012 0.0012
Trypanosoma cruzi cytochrome P450, putative 0.004 0.0035 0.0102
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0109 0.0136 0.8905
Trichomonas vaginalis hypothetical protein 0.0024 0.0011 0.0154
Schistosoma mansoni hypothetical protein 0.0061 0.0066 0.0066
Echinococcus multilocularis survival motor neuron protein 1 0.0754 0.1087 0.1087
Brugia malayi Protein kinase domain containing protein 0.0031 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.6808 1 1
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0024 0.0011 0.0011
Brugia malayi SET domain containing protein 0.0028 0.0017 0.0017
Echinococcus multilocularis neuropeptide FF receptor 2 0.0024 0.0012 0.0012
Brugia malayi F/Y-rich N-terminus family protein 0.003 0.002 0.002
Loa Loa (eye worm) norepinephrine transporter 0.6808 1 1
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0011 0.0065
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0115 0.0144 1
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.005 0.0049 0.0049
Treponema pallidum bacterioferrin (TpF1) 0.0018 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.001
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0103 0.0127 0.8265
Loa Loa (eye worm) hypothetical protein 0.005 0.0049 0.0047
Schistosoma mansoni histamine h1 receptor 0.0024 0.0012 0.0012
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0021 0.0006 0.0006
Plasmodium vivax glutathione reductase, putative 0.0047 0.0046 0.0272
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0075 0.0087 0.0257
Onchocerca volvulus 0.0024 0.0012 0.0004
Echinococcus granulosus sodium and chloride dependent glycine 0.1156 0.1677 0.1677
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0024 0.0011 0.0065
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0011 0.0154
Loa Loa (eye worm) hypothetical protein 0.6808 1 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0065 0.0071 0.0071
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0108 0.0135 0.8837
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.001
Loa Loa (eye worm) phosphatidylinositol 3 0.0032 0.0023 0.002
Brugia malayi hypothetical protein 0.0061 0.0066 0.0066
Onchocerca volvulus 0.1156 0.1677 0.1671
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0012 0.0012
Schistosoma mansoni sodium/chloride dependent transporter 0.6808 1 1
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0018 0.0002 0.0125
Loa Loa (eye worm) phosphofructokinase 0.0109 0.0136 0.0134
Loa Loa (eye worm) hypothetical protein 0.0042 0.0037 0.0035
Schistosoma mansoni hypothetical protein 0.0024 0.0012 0.0012
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.005 0.0049 0.0049
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0441 0.0625 0.0623
Onchocerca volvulus 0.0024 0.0012 0.0004
Echinococcus granulosus inositol monophosphatase 1 0.0115 0.0144 0.0144
Echinococcus granulosus serotonin receptor 0.0024 0.0012 0.0012
Schistosoma mansoni apoferritin-2 0.0018 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0024 0.0012 0.0012
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0002 0.0002
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0019 0.0269
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.003 0.002 0.1325
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.0001
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0075 0.0087 0.0257
Echinococcus granulosus RUN 0.0061 0.0066 0.0066
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0031 0.0021 0.0021
Onchocerca volvulus 0.0024 0.0012 0.0004
Onchocerca volvulus 0.0061 0.0066 0.0058
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.003 0.002 0.1404
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.001
Echinococcus granulosus 7TM GPCR rhodopsin 0.0024 0.0012 0.0012
Brugia malayi G-protein coupled receptor 0.0024 0.0012 0.0012
Echinococcus granulosus allatostatin A receptor 0.0024 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.001
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0012 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0062 0.0066 0.0929
Brugia malayi AKH receptor 0.0024 0.0012 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0013 0.0185
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0045 0.0042 0.0581
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0011 0.047
Schistosoma mansoni polycystin 1-related 0.0061 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.005 0.0049 0.0047
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0024 0.0022
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0107 0.0134 0.0396
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0024 0.0012 0.0012
Echinococcus granulosus lamin 0.0086 0.0102 0.0102
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.0136 0.0136
Onchocerca volvulus 0.6808 1 1
Schistosoma mansoni netrin receptor unc5 0.003 0.002 0.002
Loa Loa (eye worm) hypoxia-induced factor 1 0.0166 0.0221 0.0219
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0012 0.0012
Schistosoma mansoni ferritin 0.0018 0.0002 0.0002
Toxoplasma gondii histone lysine methyltransferase SET1 0.0176 0.0235 0.14
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0075 0.5167
Schistosoma mansoni aryl hydrocarbon receptor 0.0054 0.0055 0.0055
Trichomonas vaginalis chromobox protein, putative 0.0082 0.0097 0.1359
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0098 0.012 0.012
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.003 0.002 0.1325
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.003 0.002 0.006
Plasmodium vivax hypothetical protein, conserved 0.1156 0.1677 1
Loa Loa (eye worm) serotonin transporter b 0.6808 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0071 0.0071
Echinococcus granulosus nuclear factor of activated T cells 5 0.0155 0.0205 0.0205
Onchocerca volvulus 0.0024 0.0012 0.0004
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.001
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0029 0.0019 0.0019
Echinococcus multilocularis expressed protein 0.0018 0.0002 0.0002
Brugia malayi Dopamine receptor protein 2 0.0024 0.0012 0.0012
Toxoplasma gondii hypothetical protein 0.1156 0.1677 1
Toxoplasma gondii thioredoxin reductase 0.0047 0.0046 0.0272
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0012 0.0012
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0052 0.0052 0.0044
Schistosoma mansoni neuropeptide receptor 0.0024 0.0012 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0052 0.0726
Brugia malayi Thioredoxin reductase 0.0047 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0028 0.0017 0.0015

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 30 uM Inhibitory activity against DNA-dependent protein kinase receptor ChEMBL. 16302822
IC50 (binding) > 30 uM Inhibitory activity against DNA-dependent protein kinase receptor ChEMBL. 16302822

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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